[go: up one dir, main page]

MA29731B1 - Derives de pyridazinone utilises comme agonistes du recepteur de l'hormone tyroïdienne - Google Patents

Derives de pyridazinone utilises comme agonistes du recepteur de l'hormone tyroïdienne

Info

Publication number
MA29731B1
MA29731B1 MA30618A MA30618A MA29731B1 MA 29731 B1 MA29731 B1 MA 29731B1 MA 30618 A MA30618 A MA 30618A MA 30618 A MA30618 A MA 30618A MA 29731 B1 MA29731 B1 MA 29731B1
Authority
MA
Morocco
Prior art keywords
diseases
tyroidian
receptor agonists
hormone receptor
pyridazinone derivatives
Prior art date
Application number
MA30618A
Other languages
English (en)
Inventor
Nancy-Ellen Haynes
Denis John Kertesz
Sherrie Lynn Pietranico-Cole
Yimin Qian
Nathan Robert Scott
Sung-Sau So
Kshitij Chhabilbhai Thakkar
Jefferson Wright Tilley
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA29731B1 publication Critical patent/MA29731B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C07D237/16—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/18—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'INVENTION CONCERNE DES COMPOSÉS DE LA FORMULE (I) ET DES SELS PHARMACEUTIQUEMENT ACCEPTABLES DE CES DERNIERS, LES SUBSTITUANTS ÉTANT TELS QUE MENTIONNÉS DANS LA DESCRIPTION. LES COMPOSÉS PRÉCITÉS, ET LES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, SONT UTILISÉS DANS LE TRAITEMENT DE MALADIES TELLES QUE L'OBÉSITÉ, L'HYPERLIPIDÉMIE, L'HYPERCHOLESTÉROLÉMIE ET LE DIABÈTE ET AUTRES AFFECTIONS ET MALADIES LIÉES, ET PEUVENT ÊTRE UTILISÉS POUR D'AUTRES MALADIES TELLES QUE LA STÉATO-HÉPATITE NON ALCOOLIQUE (NASH), L'ATHÉROSCLÉROSE, LES MALADIES CARDIOVASCULAIRES, L'HYPOTHYROÏDIE, LE CANCER DE LA THYROÏDE ET AUTRES AFFECTIONS ET MALADIES LIÉES.
MA30618A 2005-07-21 2008-02-01 Derives de pyridazinone utilises comme agonistes du recepteur de l'hormone tyroïdienne MA29731B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70121505P 2005-07-21 2005-07-21

Publications (1)

Publication Number Publication Date
MA29731B1 true MA29731B1 (fr) 2008-09-01

Family

ID=37114368

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30618A MA29731B1 (fr) 2005-07-21 2008-02-01 Derives de pyridazinone utilises comme agonistes du recepteur de l'hormone tyroïdienne

Country Status (31)

Country Link
US (3) US7452882B2 (fr)
EP (1) EP1919878B1 (fr)
JP (1) JP5000649B2 (fr)
KR (1) KR100965006B1 (fr)
CN (1) CN101228135B (fr)
AR (1) AR054848A1 (fr)
AT (1) ATE480524T1 (fr)
AU (1) AU2006271721C1 (fr)
BR (1) BRPI0613754B8 (fr)
CA (1) CA2614529C (fr)
CR (1) CR9644A (fr)
CY (1) CY1110929T1 (fr)
DE (1) DE602006016821D1 (fr)
DK (1) DK1919878T3 (fr)
EC (1) ECSP088120A (fr)
ES (1) ES2349131T3 (fr)
HR (1) HRP20100633T1 (fr)
IL (1) IL188476A (fr)
MA (1) MA29731B1 (fr)
MX (1) MX2008000818A (fr)
MY (1) MY142861A (fr)
NO (1) NO340679B1 (fr)
NZ (1) NZ565190A (fr)
PL (1) PL1919878T3 (fr)
PT (1) PT1919878E (fr)
RS (1) RS51639B (fr)
RU (1) RU2379295C2 (fr)
TW (1) TWI330636B (fr)
UA (1) UA88104C2 (fr)
WO (1) WO2007009913A1 (fr)
ZA (1) ZA200800405B (fr)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007512359A (ja) 2003-11-19 2007-05-17 メタバシス・セラピューティクス・インコーポレイテッド 新規なリン含有甲状腺ホルモン様物質
EP1604988A1 (fr) * 2004-05-18 2005-12-14 Sanofi-Aventis Deutschland GmbH Dérivés de pyridazinone, méthodes de leur préparation et leur utilisation comme pharmaceutiques
CA2606499C (fr) 2005-05-26 2017-06-13 Metabasis Therapeutics, Inc. Composes thyromimetiques utilises pour traiter les maladies hepatiques graisseuses
CA2614529C (fr) 2005-07-21 2011-06-28 F. Hoffmann-La Roche Ag Derives de pyridazinone utilises comme agonistes du recepteur de l'hormone thyroidienne
GB0610680D0 (en) * 2006-05-31 2006-07-12 Istituto Di Ricerche D Biolog Therapeutic compounds
AU2007283113A1 (en) 2006-08-08 2008-02-14 Sanofi-Aventis Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use
JPWO2008133141A1 (ja) * 2007-04-24 2010-07-22 東洋紡績株式会社 オスモチン組換えタンパク質およびその製造方法、並びにその利用
PL2061766T3 (pl) 2007-06-06 2011-02-28 Torrent Pharmaceuticals Ltd Nowe związki
US8076334B2 (en) * 2007-09-20 2011-12-13 Hoffmann-La Roche Inc. Prodrugs of thyroid hormone analogs
ES2524787T3 (es) 2007-11-15 2014-12-12 Msd Italia S.R.L. Derivados de piridazinona como inhibidores de PARP
KR100981781B1 (ko) 2008-02-29 2010-09-10 재단법인 한국원자력의학원 방사선 치료용 콜리메이터 장치 및 그 장치를 이용한방사선 치료장치
UY31968A (es) 2008-07-09 2010-01-29 Sanofi Aventis Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos
WO2010068601A1 (fr) 2008-12-08 2010-06-17 Sanofi-Aventis Hydrate de fluoroglycoside hétéroaromatique cristallin, ses procédés de fabrication, ses procédés d'utilisation et compositions pharmaceutiques le contenant
BRPI1015096A2 (pt) 2009-04-20 2016-05-03 Mitsubishi Tanabe Pharma Corp agonista de receptor beta de hormônio tireoideano
BR112012003973A2 (pt) 2009-08-26 2015-09-08 Sanofi Sa hidratos de fluoroglicosídeo heteroaromático cristalinos, produtos farmacêuticos compreendendo estes compostos e seu uso
JP5847533B2 (ja) * 2010-10-19 2016-01-27 田辺三菱製薬株式会社 新規甲状腺ホルモンβ受容体作動薬
WO2012120052A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés d'oxathiazine substitués par des carbocycles ou des hétérocycles, leur procédé de préparation, médicaments contenant ces composés et leur utilisation
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683705B1 (fr) 2011-03-08 2015-04-22 Sanofi Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
WO2012120053A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine ramifiés, procédé pour leur préparation, utilisation en tant que médicament, agents pharmaceutiques contenant ces dérivés et leur utilisation
WO2012120056A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine tétra-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
CA3111317C (fr) * 2012-09-17 2023-08-29 F. Hoffmann-La Roche Ltd. Procede de synthese d'analogues de l'hormone thyroidienne et de ses polymorphes
CN105272927A (zh) * 2015-11-17 2016-01-27 华中药业股份有限公司 一种制备氯氮卓的新方法
AU2017346871B2 (en) 2016-10-18 2023-08-03 Madrigal Pharmaceuticals, Inc. Methods of treating liver disorders or lipid disorders with a THR-beta agonist
WO2018094265A2 (fr) 2016-11-21 2018-05-24 Viking Therapeutics, Inc. Méthodes de traitement de glycogénose
CN110996966A (zh) 2017-06-05 2020-04-10 维京治疗公司 用于治疗纤维化的组合物
EP3683306A4 (fr) 2017-09-14 2021-06-09 Riken Procédé de production de tissus rétiniens
CN109574995B (zh) * 2018-01-23 2020-07-24 深圳市塔吉瑞生物医药有限公司 取代的哒嗪酮化合物
KR20200138283A (ko) 2018-03-22 2020-12-09 바이킹 테라퓨틱스 인코포레이티드 결정질 형태, 및 결정질 형태의 화합물을 제조하는 방법
CA3095872A1 (fr) 2018-04-16 2019-10-24 Ioulia Tseti Composition pharmaceutique de poudre seche pour inhalation comprenant une hormone thyroidienne
US11964964B2 (en) * 2018-06-12 2024-04-23 Xizang Haisco Pharmaceutical Co., Ltd. Thyroid hormone receptor agonists and uses thereof
US20210292304A1 (en) * 2018-06-22 2021-09-23 Hinova Pharmaceuticals Inc. Deuterated mgl-3196 compound and use thereof
TW202019914A (zh) * 2018-07-02 2020-06-01 美商瑪德瑞高製藥公司 ２-（３，５-二氯-４-（（５-異丙基-６-側氧基-１，６-二氫噠嗪-３-基）氧）苯基）-３，５-二側氧基-２，３，４，５-四氫-１，２，４-三嗪-６-腈之固體型式
US10800767B2 (en) * 2018-08-24 2020-10-13 Terns, Inc. Thyroid hormone receptor beta agonist compounds
KR102876077B1 (ko) * 2018-09-06 2025-10-23 갈메드 리서치 앤드 디벨롭먼트 리미티드 간 질환을 치료하기 위한 병용 요법
TWI840423B (zh) * 2018-10-12 2024-05-01 美商拓臻股份有限公司 甲狀腺素受體β促效劑化合物
AU2019359141A1 (en) * 2018-10-12 2021-04-22 InventisBio Co., Ltd. Thyroid hormone receptor agonists
WO2020117962A1 (fr) 2018-12-05 2020-06-11 Viking Therapeutics, Inc. Compositions pour le traitement de la fibrose et de l'inflammation
CN121081472A (zh) 2018-12-13 2025-12-09 拓臻股份有限公司 一种THRβ受体激动剂化合物及其制备方法和用途
CN111592528A (zh) * 2019-02-20 2020-08-28 苏州泽璟生物制药股份有限公司 氘代的哒嗪酮及其衍生物和药物组合物
EP3927693A4 (fr) * 2019-02-21 2023-04-05 Nanjing Ruijie Pharma Co., Ltd. Nouveaux composés et leurs utilisations en tant qu'agonistes du récepteur de l'hormone thyroïdienne
MY206063A (en) 2019-03-13 2024-11-27 Riken Method for evaluating quality of transplant neural retina, and transplant neural retina sheet
AU2020267576B2 (en) 2019-05-08 2025-03-13 Aligos Therapeutics, Inc. Modulators of THR-β and methods of use thereof
WO2020228577A1 (fr) * 2019-05-10 2020-11-19 深圳微芯生物科技股份有限公司 Dérivé de pyridazinone et son utilisation
CN114174282A (zh) * 2019-05-29 2022-03-11 南京明德新药研发有限公司 作为甲状腺素受体-β激动剂的哒嗪酮类衍生物及其应用
EP4019524A4 (fr) 2019-08-19 2024-01-03 Hepagene Therapeutics (HK) Limited Composé agoniste du récepteur thr-bêta hétérocyclique, son procédé de préparation et son utilisation
CN112409340B (zh) * 2019-08-21 2022-03-18 海创药业股份有限公司 卤素取代的苯醚类化合物及其用途
EP4017875A4 (fr) * 2019-08-23 2023-05-03 Terns Pharmaceuticals, Inc. Composés agonistes du récepteur bêta de l'hormone thyroïdienne
WO2021043185A1 (fr) * 2019-09-04 2021-03-11 Sunshine Lake Pharma Co., Ltd. Composé utilisé comme agoniste du récepteur bêta des hormones thyroïdiennes et son utilisation
CA3154391A1 (fr) * 2019-09-12 2021-03-18 Terns Pharmaceuticals, Inc. Composes agonistes du recepteur beta de l'hormone thyroidienne
JP7634526B2 (ja) * 2019-09-24 2025-02-21 ▲広▼▲東▼▲東▼▲陽▼光▲薬▼▲業▼有限公司 甲状腺ホルモンベータ受容体アゴニストとしての化合物及びその使用
CN112707892A (zh) * 2019-10-24 2021-04-27 苏州泽璟生物制药股份有限公司 哒嗪酮或哒嗪类化合物及其衍生物和药物组合物
CA3158379A1 (fr) * 2019-11-26 2021-06-03 Hejun Lv Compose de 1,2,4-triazine-3,5-dione, son procede de preparation et son utilisation
WO2021129465A1 (fr) * 2019-12-26 2021-07-01 苏州科睿思制药有限公司 Cristal de resmétirom, son procédé de préparation et ses utilisations
CN113045551B (zh) * 2019-12-27 2024-07-09 广东东阳光药业股份有限公司 一种作为甲状腺激素β受体激动剂的化合物及其用途
CA3164404A1 (fr) 2020-01-13 2021-07-22 Jingye Zhou Agonistes du recepteur des hormones thyroidiennes et utilisations connexes
CN113278013B (zh) * 2020-02-20 2022-09-23 昆药集团股份有限公司 2,6-二取代的1,2,4-三嗪-3,5-二酮化合物及其制备方法和应用
CN113698388B (zh) * 2020-05-20 2022-11-22 江苏恒瑞医药股份有限公司 6-氧代-1,6-二氢吡啶类衍生物、其制备方法及其在医药上的应用
EP4159723B1 (fr) 2020-06-02 2025-07-23 Chengdu Kanghong Pharmaceutical Co., Ltd. Nouvel agoniste du récepteur beta de l'hormone thyroïdienne
US20230339911A1 (en) * 2020-08-27 2023-10-26 InventisBio Co., Ltd. Pyridazinone compounds
WO2022053028A1 (fr) * 2020-09-10 2022-03-17 南京明德新药研发有限公司 Composé de 1,2,4-triazine-3,5-(2h,4h)-dicétone et son utilisation
EP4286377A4 (fr) * 2020-09-10 2024-10-09 Crystal Pharmaceutical (Suzhou) Co., Ltd. Forme cristalline de resmetirom, son procédé de préparation et son utilisation
WO2022054924A1 (fr) 2020-09-11 2022-03-17 大日本住友製薬株式会社 Milieu pour tissu destiné à la transplantation
JPWO2022054925A1 (fr) 2020-09-11 2022-03-17
TW202220977A (zh) * 2020-09-30 2022-06-01 大陸商江蘇恆瑞醫藥股份有限公司 ６－側氧－１，６－二氫噠嗪類衍生物、其製備方法及其在醫藥上的應用
WO2022086894A1 (fr) 2020-10-19 2022-04-28 Teva Pharmaceuticals International Gmbh Formes solides de resmetirom
WO2022087141A1 (fr) * 2020-10-23 2022-04-28 Madrigal Pharmaceuticals, Inc. Procédé de préparation de dérivés de 6-(4-nitro-phénoxy)-2h-pyridazin-3-one et de 6-(4-amino-phénoxy)-2h-pyridazin-3-one en tant qu'intermédiaires d'analogues des hormones thyroïdiennes
CN114437042A (zh) * 2020-11-03 2022-05-06 深圳微芯生物科技股份有限公司 酞嗪类化合物的晶型及其制备方法
CA3197249A1 (fr) * 2020-11-06 2022-05-12 David Craig Mcgowan Pyridazinones bicycliques comme beta-agonistes du recepteur des hormones thyroidiennes
CN112645936B (zh) 2020-12-17 2022-03-01 山东第一医科大学(山东省医学科学院) 取代的哒嗪酮类化合物及其用途
CN114685450A (zh) * 2020-12-30 2022-07-01 昆药集团股份有限公司 2-吡啶酮类衍生物及其制备方法和在医药上的应用
CN114907327A (zh) * 2021-02-10 2022-08-16 杭州领业医药科技有限公司 Resmetirom的晶型及其制备方法和用途
CN115073429A (zh) * 2021-03-15 2022-09-20 昆药集团股份有限公司 一种1，2，4-三嗪-3，5-二酮类化合物的盐型、晶型及其制备方法
CN116063296B (zh) * 2021-11-02 2025-08-19 凯思凯迪（上海）医药科技有限公司 一种作为甲状腺激素β受体激动剂的化合物及其用途
JPWO2023090427A1 (fr) 2021-11-19 2023-05-25
KR20240163659A (ko) * 2022-03-10 2024-11-19 세키스이가가쿠 고교가부시키가이샤 바이러스 감염 저지제, 바이러스 감염 저지 제품, 바이러스 감염 저지 도료 및 수지 조성물
CN116836158A (zh) * 2022-03-23 2023-10-03 凯思凯迪（上海）医药科技有限公司 一种作为甲状腺激素β受体激动剂的化合物及其用途
WO2024084491A1 (fr) * 2022-10-21 2024-04-25 Mehta Nilesh Vipinchandra Procédé de synthèse de res metirom et de ses intermédiaires
CN118146217A (zh) 2022-12-07 2024-06-07 昆药集团股份有限公司 一种甲状腺激素β受体激动剂、晶型、制备方法和用途
CN115650928B (zh) * 2022-12-28 2023-03-31 凯思凯旭(上海)医药科技有限公司 一种多环类甲状腺激素β受体激动剂及其用途
WO2024141076A1 (fr) * 2022-12-29 2024-07-04 Gannex Pharma Co., Ltd. Promédicaments pour analogues d'hormones thyroïdiennes et leur procédé de fabrication et d'utilisation
KR20250166323A (ko) 2023-04-07 2025-11-27 테른스 파마슈티칼스, 인크. 간 장애 또는 심장대사 질환의 치료에 사용하기 위한 thr베타 효현제 및 glp-1r 효현제를 포함하는 조합
CN116768802B (zh) * 2023-05-25 2025-11-21 杭州科巢生物科技有限公司 一种瑞司美替罗的合成方法
WO2025011259A1 (fr) * 2023-07-07 2025-01-16 苏州科睿思制药有限公司 Forme cristalline de resmetirom, son procédé de préparation et son utilisation
CN117263870A (zh) * 2023-09-21 2023-12-22 江西同和药业股份有限公司 一种Resmetirom关键中间体III的制备方法
WO2025083699A2 (fr) 2023-10-16 2025-04-24 Cipla Limited Polymorphes de resmétirom et procédé associé
US12377104B1 (en) 2024-02-06 2025-08-05 Madrigal Pharmaceuticals, Inc. Methods for treating a fatty liver disease
WO2025171032A1 (fr) 2024-02-06 2025-08-14 Madrigal Pharmaceuticals, Inc. Méthodes de traitement d'une stéatose hépatique
WO2025191457A1 (fr) * 2024-03-13 2025-09-18 Morepen Laboratories Limited Procédé de préparation d'un dérivé de pyridazinone
WO2025230749A1 (fr) 2024-05-03 2025-11-06 Aligos Therapeutics, Inc. Procédés de préparation de 6-amino-2-[3,5-dichloro-4-[(5-isopropyl-6-oxo -1 h-pyridazin-3-yl) oxy] phényl]-4 h-1, 2, 4-tri-azine-3, 5-dione
CN119798230B (zh) * 2025-03-13 2025-06-27 中国药科大学 吲哚酮类化合物及其在治疗急慢性肝病与促进组织修复中的应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4582842A (en) 1981-02-25 1986-04-15 Merck & Co., Inc. Anti-asthmatic 6H-dibenz-[b,e] [1,4]oxathiepin derivatives, compositions, and method of use therefor
GB8501372D0 (en) * 1985-01-18 1985-02-20 Smith Kline French Lab Chemical compounds
US5284971A (en) * 1992-07-16 1994-02-08 Syntex (U.S.A.) Inc. 4-(3-cyclohexyl-4-hydroxy or-methoxy phenylsulfonyl) 3,5 dibromo phenyl acetic thyromimetic cholesterol-lowering agents
AU4440596A (en) 1995-02-10 1996-08-22 Smithkline Beecham Corporation Use of hcp SH2 specific compounds to enhance erythropoiesis
FI974435L (fi) 1995-06-06 1997-12-05 Pfizer Menetelmä 2,4-diklooripyridiinien muuttamiseksi 2-aryylioksi-4-klooripyridiineiksi
WO1997002023A1 (fr) 1995-06-30 1997-01-23 Smithkline Beecham Corporation UTILISATION DE COMPOSES SPECIFIQUES DU DOMAINE Stat 6 SH2 POUR LE TRAITEMENT DES REACTIONS ALLERGIQUES
US5883294A (en) 1997-06-18 1999-03-16 The Regeants Of The University Of California Selective thyroid hormone analogs
GB9713739D0 (en) * 1997-06-27 1997-09-03 Karobio Ab Thyroid receptor ligands
CN1142148C (zh) * 1997-11-19 2004-03-17 兴和株式会社 新颖的哒嗪衍生物和含有其作为有效成分的药物
AR023659A1 (es) 1998-09-18 2002-09-04 Vertex Pharma Un compuesto inhibidor de p38, una composicion farmaceutica que lo comprende y el uso de dicha composicion en el tratamiento y prevencion de estados patologicos
IL144765A0 (en) * 1999-03-01 2002-06-30 Pfizer Prod Inc Oxamic acids and derivatives as thyroid receptor ligands
JP2004517851A (ja) * 2000-12-27 2004-06-17 バイエル アクチェンゲゼルシャフト 甲状腺受容体のリガンドとしてのインドール誘導体
KR20030072396A (ko) * 2001-02-08 2003-09-13 카로 바이오 아베 갑상선 수용체 리간드
DE60204611T2 (de) * 2001-02-28 2006-05-11 Pfizer Products Inc., Groton Sulfonyl-pyridazinon-derivate zur Verwendung als Aldose-reduktase-inhibitoren
MXPA05010081A (es) * 2003-03-24 2005-11-23 Hoffmann La Roche Bencil-piridazinonas como inhibidores de transcriptasa inversa.
JP2007512359A (ja) 2003-11-19 2007-05-17 メタバシス・セラピューティクス・インコーポレイテッド 新規なリン含有甲状腺ホルモン様物質
JP4627315B2 (ja) * 2004-03-23 2011-02-09 エフ．ホフマン−ラ ロシュ アーゲー 非ヌクレオシド逆転写酵素阻害剤としてのベンジルピリダジノン誘導体
CA2614529C (fr) 2005-07-21 2011-06-28 F. Hoffmann-La Roche Ag Derives de pyridazinone utilises comme agonistes du recepteur de l'hormone thyroidienne

Also Published As

Publication number Publication date
DE602006016821D1 (de) 2010-10-21
RU2379295C2 (ru) 2010-01-20
CY1110929T1 (el) 2015-06-10
TW200745052A (en) 2007-12-16
USRE46024E1 (en) 2016-06-07
BRPI0613754B1 (pt) 2021-03-16
PT1919878E (pt) 2010-11-02
BRPI0613754A2 (pt) 2011-02-08
TWI330636B (en) 2010-09-21
US7452882B2 (en) 2008-11-18
HK1115129A1 (en) 2008-11-21
RU2008106058A (ru) 2009-08-27
IL188476A (en) 2011-10-31
PL1919878T3 (pl) 2011-03-31
ZA200800405B (en) 2008-12-31
DK1919878T3 (da) 2010-10-25
CA2614529C (fr) 2011-06-28
ATE480524T1 (de) 2010-09-15
NO340679B1 (no) 2017-05-29
WO2007009913A1 (fr) 2007-01-25
CN101228135A (zh) 2008-07-23
ECSP088120A (es) 2008-02-20
IL188476A0 (en) 2008-04-13
EP1919878A1 (fr) 2008-05-14
NO20080058L (no) 2008-04-18
US7807674B2 (en) 2010-10-05
AU2006271721B2 (en) 2010-06-17
CA2614529A1 (fr) 2007-01-25
RS51639B (sr) 2011-10-31
KR20080019297A (ko) 2008-03-03
NZ565190A (en) 2010-02-26
JP2009501759A (ja) 2009-01-22
UA88104C2 (ru) 2009-09-10
KR100965006B1 (ko) 2010-06-21
US20070032494A1 (en) 2007-02-08
AU2006271721C1 (en) 2013-09-19
AU2006271721A1 (en) 2007-01-25
AR054848A1 (es) 2007-07-18
US20090005383A1 (en) 2009-01-01
CN101228135B (zh) 2011-08-31
ES2349131T3 (es) 2010-12-28
BRPI0613754B8 (pt) 2021-05-25
MX2008000818A (es) 2008-03-18
MY142861A (en) 2011-01-14
HRP20100633T1 (hr) 2011-01-31
EP1919878B1 (fr) 2010-09-08
CR9644A (es) 2008-02-20
JP5000649B2 (ja) 2012-08-15

Similar Documents

Publication Publication Date Title
MA29731B1 (fr) Derives de pyridazinone utilises comme agonistes du recepteur de l'hormone tyroïdienne
MA30142B1 (fr) Agonistes du recepteur de neuropeptide-2
MA31683B1 (fr) Composes et procedes pour moduler fxr
MA29170B1 (fr) Derives puriniques agissant comme des agonistes du recepteur a2a
MA29909B1 (fr) Derives de pyridazine
MA34207B1 (fr) Inhibiteurs de la pi3 kinase et/ou du mtor
TNSN08445A1 (fr) Derives de triazolopyrazine utiles comme agent anticancereux
MA28747B1 (fr) Dérivés de pyridine
TNSN97193A1 (fr) Amides inhibiteurs de secretion de apo b/mtp, procede pour leur preparation et compositions pharmaceutiques les contenant.
MA27728A1 (fr) Antagonistes des recepteurs de cgrp
MA30602B1 (fr) Modulateurs du metabolisme, et traitement de troubles au moyen de ces modulateurs
MA29550B1 (fr) Derives de n- (pyridine-2-yl) - sulfonamide
MA27774A1 (fr) Inhibiteurs de phosphatidylinositol 3-kinase
MA30232B1 (fr) Inhibiteurs de kinase bases sur l'hydantoine
MA31373B1 (fr) Composes amino-heterocycliques
MA29148B1 (fr) Derives de pyrazole condenses, et procedes pour traiter des troubles lies au metabolisme
MA33056B1 (fr) Composition pharmaceutique solide comprenant de l'amlodipine et du losartan et son procede de fabrication
MA29713B1 (fr) Derives de tetrahydroindolone et de tetrahydroindazolone
MA27883A1 (fr) Derives de pyrido [2,1-a] isoquinoline utilises comme inhibiteurs de dpp-iv
MA30696B1 (fr) Derives de l'acide (3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)-acetique
TN2009000450A1 (fr) Derives de pyridine
MA33219B1 (fr) Derives d'azoanthracene substitues, compositions pharmaceutiques et leurs procedes d'utilisation
MA29926B1 (fr) Derives de pyrazine
MA30289B1 (fr) Dérivés d'amines
TNSN98203A1 (fr) Derives de thienopyrimidine et tienopyridine utiles comme agents anticancereux, et compositions les contenant