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MA30142B1 - Agonistes du recepteur de neuropeptide-2 - Google Patents

Agonistes du recepteur de neuropeptide-2

Info

Publication number
MA30142B1
MA30142B1 MA31085A MA31085A MA30142B1 MA 30142 B1 MA30142 B1 MA 30142B1 MA 31085 A MA31085 A MA 31085A MA 31085 A MA31085 A MA 31085A MA 30142 B1 MA30142 B1 MA 30142B1
Authority
MA
Morocco
Prior art keywords
neuropeptide
receptor agonists
obesity
diabetes
moieties
Prior art date
Application number
MA31085A
Other languages
English (en)
Inventor
Karin Conde-Knape
Waleed Danho
George Ehrlich
Nader Fotouhi
David C Fry
Wajiha Khan
Anish Konkar
Cristina Martha Rondinone
Joseph Swistok
Rebecca Anne Taub
Jefferson Wright Tilley
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37964711&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA30142(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA30142B1 publication Critical patent/MA30142B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57545—Neuropeptide Y
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Agonistes du récepteur de neuropeptide-2 Il est proposé dans le présent mémoire des agonistes du récepteur de neuropeptide-2, de formule (I), Y¿ I Y-R1-R2-X-R3-R4-R5-R6-R7-R8-R9-R10-R11-R12-R13-R14-NH2 (I) ainsi que leurs sels, dérivés et fragments pharmaceutiquement acceptables, formule dans laquelle les substituants sont ceux décrits dans le présent mémoire. Ces composés, et les compositions pharmaceutiques les contenant, sont utiles pour le traitement de maladies telles que, par exemple, l'obésité et le diabète.
MA31085A 2005-12-07 2008-07-01 Agonistes du recepteur de neuropeptide-2 MA30142B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74807105P 2005-12-07 2005-12-07
US85524906P 2006-10-30 2006-10-30

Publications (1)

Publication Number Publication Date
MA30142B1 true MA30142B1 (fr) 2009-01-02

Family

ID=37964711

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31085A MA30142B1 (fr) 2005-12-07 2008-07-01 Agonistes du recepteur de neuropeptide-2

Country Status (18)

Country Link
US (2) US7642244B2 (fr)
EP (1) EP1962959B1 (fr)
JP (1) JP5000663B2 (fr)
KR (1) KR101059602B1 (fr)
AR (1) AR057222A1 (fr)
AT (1) ATE549350T1 (fr)
AU (1) AU2006324076A1 (fr)
BR (1) BRPI0619573A2 (fr)
CA (1) CA2630649A1 (fr)
EC (1) ECSP088511A (fr)
ES (1) ES2381497T3 (fr)
IL (1) IL191636A (fr)
MA (1) MA30142B1 (fr)
NO (1) NO20082445L (fr)
NZ (1) NZ568772A (fr)
RU (2) RU2430108C2 (fr)
TW (1) TWI321474B (fr)
WO (1) WO2007065808A2 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010069242A (ko) * 2000-09-05 2001-07-25 양우용 저주파 물리치료 겸용 혈압 강하기
AU2006324076A1 (en) * 2005-12-07 2007-06-14 F. Hoffmann-La Roche Ag Neuropeptide-2 receptor-agonists
US8299023B2 (en) * 2008-09-17 2012-10-30 Hoffmann-La Roche Inc. Neuropeptide-2 receptor (Y-2R) agonists
CA2741921A1 (fr) * 2008-11-05 2010-05-14 F. Hoffmann-La Roche Ag Agonistes du recepteur 2 de neuropeptide (y-2r) et leurs utilisations
EP2450374B9 (fr) 2009-07-02 2016-11-23 Takeda Pharmaceutical Company Limited Peptide et son utilisation
JP2013505221A (ja) * 2009-09-18 2013-02-14 ノヴォ ノルディスク アー／エス 長時間作用性ｙ２受容体アゴニスト
WO2011045232A2 (fr) * 2009-10-13 2011-04-21 F. Hoffmann-La Roche Ag Agonistes du récepteur du neuropeptide-2 (y-2r)
RU2600440C3 (ru) 2010-12-16 2021-12-10 Ново Нордиск А/С Твердые композиции, содержащие агонист glp-1 и соль n-(8-(2-гидроксибензоил)амино)каприловой кислоты
CA2822481A1 (fr) 2011-01-03 2012-07-12 F. Hoffmann-La Roche Ag Composition pharmaceutique a base d'un complexe associant un anticorps anti-dig et de la digoxigenine conjuguee a un peptide
US10933120B2 (en) 2012-03-22 2021-03-02 Novo Nordisk A/S Compositions of GLP-1 peptides and preparation thereof
EP3339328A1 (fr) 2012-07-04 2018-06-27 F. Hoffmann-La Roche AG Anticorps anti-biotine et procédés d'utilisation
KR102090849B1 (ko) 2012-07-04 2020-03-19 에프. 호프만-라 로슈 아게 공유 결합된 항원-항체 접합체
EP2869837B1 (fr) 2012-07-04 2016-09-14 F. Hoffmann-La Roche AG Anticorps anti-théophylline et procédés dýutilisation
AU2014261336B2 (en) 2013-05-02 2019-02-28 Novo Nordisk A/S Oral dosing of GLP-1 compounds
US9085637B2 (en) 2013-11-15 2015-07-21 Novo Nordisk A/S Selective PYY compounds and uses thereof
US10583172B2 (en) 2013-11-15 2020-03-10 Novo Nordisk A/S HPYY(1-36) having a beta-homoarginine substitution at position 35
JP6602304B2 (ja) 2014-01-03 2019-11-06 エフ．ホフマン−ラ ロシュ アーゲー 共有結合で連結されたヘリカー−抗ヘリカー抗体コンジュゲートおよびその用途
EP3089759B1 (fr) 2014-01-03 2018-12-05 F. Hoffmann-La Roche AG Conjugués covalents entre un anticorps et une toxine polypeptidique
PL3089996T3 (pl) 2014-01-03 2021-12-13 F. Hoffmann-La Roche Ag Dwuswoiste przeciwciała przeciw haptenowi/przeciw receptorowi występującemu w barierze krew-mózg, ich kompleksy i ich zastosowanie jako przenośniki wahadłowe występujące w barierze krew-mózg
MA41898A (fr) * 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
TWI694082B (zh) 2015-06-12 2020-05-21 丹麥商諾佛 儂迪克股份有限公司 選擇性ｐｙｙ化合物及其用途
BR112020014624A2 (pt) 2018-02-02 2020-12-08 Novo Nordisk A/S Composições sólidas compreendendo agonista de glp-1, sal de ácido n-(8-(2-hidroxibenzoil) amino)caprílico e lubrificante
MX2022005661A (es) 2019-11-11 2022-09-07 Boehringer Ingelheim Int Agonistas del receptor npy2.
WO2022029231A1 (fr) 2020-08-07 2022-02-10 Boehringer Ingelheim International Gmbh Agonistes du récepteur npy2 solubles

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5080891A (en) * 1987-08-03 1992-01-14 Ddi Pharmaceuticals, Inc. Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
PL310897A1 (en) * 1993-03-29 1996-01-08 Univ Cincinnati Analogues of yy peptide and their application
AUPO029096A0 (en) 1996-06-05 1996-07-04 Crc For Biopharmaceutical Research Pty Ltd Npy y2 agonists
US6013633A (en) * 1997-08-07 2000-01-11 University Of Cincinnati Compounds for control of appetite, blood pressure, cardiovascular response, libido, and circadian rhythm
EP1202986B1 (fr) * 1999-07-28 2005-10-12 Ortho-McNeil Pharmaceutical, Inc. Derives d'amines et d'amides utilises en tant que ligands pour le recepteur y5 du neuropeptide y, utile dans le traitement de l'obesite et d'autres troubles
EP2277527A3 (fr) 2003-01-17 2011-08-31 Ipsen Pharma Analogues du peptide yy
CA2521784C (fr) 2003-04-08 2012-03-27 Yeda Research And Development Co. Ltd. Medicaments pegyles reversibles
WO2005053726A1 (fr) 2003-11-25 2005-06-16 Bayer Pharmaceuticals Corporation Agonistes selectifs du recepteur de neuropeptide y2
WO2005080424A2 (fr) 2004-02-23 2005-09-01 Rheoscience A/S Analogues du peptide yy
US7410949B2 (en) * 2005-01-18 2008-08-12 Hoffmann-La Roche Inc. Neuropeptide-2 receptor (Y-2R) agonists and uses thereof
WO2006091505A2 (fr) 2005-02-24 2006-08-31 Bayer Pharmaceuticals Corporation Agonistes du recepteur y de neuropeptide
AU2006324076A1 (en) * 2005-12-07 2007-06-14 F. Hoffmann-La Roche Ag Neuropeptide-2 receptor-agonists
WO2007085887A1 (fr) 2006-01-27 2007-08-02 Pfizer Products Inc. Agonistes du pyy et leurs utilisations

Also Published As

Publication number Publication date
US8268784B2 (en) 2012-09-18
ECSP088511A (es) 2008-07-30
WO2007065808A3 (fr) 2007-08-02
NO20082445L (no) 2008-09-03
ES2381497T3 (es) 2012-05-28
CA2630649A1 (fr) 2007-06-14
JP5000663B2 (ja) 2012-08-15
EP1962959A2 (fr) 2008-09-03
AR057222A1 (es) 2007-11-21
IL191636A (en) 2012-10-31
ATE549350T1 (de) 2012-03-15
US20100137223A1 (en) 2010-06-03
RU2011105310A (ru) 2012-08-20
IL191636A0 (en) 2008-12-29
KR20080082672A (ko) 2008-09-11
AU2006324076A1 (en) 2007-06-14
US20070135351A1 (en) 2007-06-14
BRPI0619573A2 (pt) 2011-10-04
TWI321474B (en) 2010-03-11
KR101059602B1 (ko) 2011-08-25
RU2008127265A (ru) 2010-01-20
RU2430108C2 (ru) 2011-09-27
US7642244B2 (en) 2010-01-05
NZ568772A (en) 2010-05-28
WO2007065808A2 (fr) 2007-06-14
TW200806311A (en) 2008-02-01
JP2009518349A (ja) 2009-05-07
EP1962959B1 (fr) 2012-03-14

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