| Identification and characterization of dual inhibitors of the USP25/28 deubiquitinating enzyme subfamily JD Wrigley, G Gavory, I Simpson, M Preston, H Plant, J Bradley, ... ACS chemical biology 12 (12), 3113-3125, 2017 | 99 | 2017 |
| Discovery of a potent and selective oral inhibitor of ERK1/2 (AZD0364) that is efficacious in both monotherapy and combination therapy in models of nonsmall cell lung cancer … RA Ward, MJ Anderton, P Bethel, J Breed, C Cook, EJ Davies, A Dobson, ... Journal of medicinal chemistry 62 (24), 11004-11018, 2019 | 76 | 2019 |
| Catalytic amidation of unactivated ester derivatives mediated by trifluoroethanol N Caldwell, C Jamieson, I Simpson, AJB Watson Chemical Communications 51 (46), 9495-9498, 2015 | 75 | 2015 |
| Organobase-catalyzed amidation of esters with amino alcohols N Caldwell, C Jamieson, I Simpson, T Tuttle Organic Letters 15 (10), 2506-2509, 2013 | 73 | 2013 |
| A modular lead-oriented synthesis of diverse piperazine, 1, 4-diazepane and 1, 5-diazocane scaffolds T James, P MacLellan, GM Burslem, I Simpson, JA Grant, S Warriner, ... Organic & Biomolecular Chemistry 12 (16), 2584-2591, 2014 | 67 | 2014 |
| Modular, gold-catalyzed approach to the synthesis of lead-like piperazine scaffolds T James, I Simpson, JA Grant, V Sridharan, A Nelson Organic Letters 15 (23), 6094-6097, 2013 | 67 | 2013 |
| Structure-guided discovery of potent and selective inhibitors of ERK1/2 from a modestly active and promiscuous chemical start point RA Ward, P Bethel, C Cook, E Davies, JE Debreczeni, G Fairley, L Feron, ... Journal of medicinal chemistry 60 (8), 3438-3450, 2017 | 64 | 2017 |
| Discovery and optimization of allosteric inhibitors of mutant isocitrate dehydrogenase 1 (R132H IDH1) displaying activity in human acute myeloid leukemia cells S Jones, J Ahmet, K Ayton, M Ball, M Cockerill, E Fairweather, N Hamilton, ... Journal of Medicinal Chemistry 59 (24), 11120-11137, 2016 | 58 | 2016 |
| Discovery of novel imidazo [1, 2-a] pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase R Ducray, I Simpson, FH Jung, JWM Nissink, PW Kenny, M Fitzek, ... Bioorganic & medicinal chemistry letters 21 (16), 4698-4701, 2011 | 58 | 2011 |
| Amidation of esters with amino alcohols using organobase catalysis N Caldwell, PS Campbell, C Jamieson, F Potjewyd, I Simpson, ... The Journal of Organic Chemistry 79 (19), 9347-9354, 2014 | 52 | 2014 |
| Development of a sustainable catalytic ester amidation process N Caldwell, C Jamieson, I Simpson, AJB Watson ACS Sustainable Chemistry & Engineering 1 (10), 1339-1344, 2013 | 52 | 2013 |
| Amidation of unactivated ester derivatives mediated by trifluoroethanol CG McPherson, N Caldwell, C Jamieson, I Simpson, AJB Watson Organic & biomolecular chemistry 15 (16), 3507-3518, 2017 | 50 | 2017 |
| Novel imidazo [1, 2-a] pyridine based inhibitors of the IGF-1 receptor tyrosine kinase: optimization of the aniline R Ducray, CD Jones, FH Jung, I Simpson, J Curwen, M Pass Bioorganic & medicinal chemistry letters 21 (16), 4702-4704, 2011 | 47 | 2011 |
| Matched molecular pair analysis of activity and properties of glycogen phosphorylase inhibitors AM Birch, PW Kenny, I Simpson, PRO Whittamore Bioorganic & medicinal chemistry letters 19 (3), 850-853, 2009 | 43 | 2009 |
| Practical synthesis of pharmaceutically relevant molecules enriched in sp 3 character PS Campbell, C Jamieson, I Simpson, AJB Watson Chemical Communications 54 (1), 46-49, 2018 | 32 | 2018 |
| Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration JG Kettle, SK Bagal, D Barratt, MS Bodnarchuk, S Boyd, E Braybrooke, ... Journal of Medicinal Chemistry 66 (13), 9147-9160, 2023 | 29 | 2023 |
| New methods for the synthesis of naphthyl amines; application to the synthesis of dihydrosanguinarine, sanguinarine, oxysanguinarine and (±)-maclekarpines B and C MR Tatton, I Simpson, TJ Donohoe Chemical Communications 50 (77), 11314-11316, 2014 | 28 | 2014 |
| ACS Sustainable Chem N Caldwell, C Jamieson, I Simpson, AJB Watson Eng 1, 1339, 2013 | 27 | 2013 |
| AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor … V Flemington, EJ Davies, D Robinson, LC Sandin, O Delpuech, P Zhang, ... Molecular cancer therapeutics 20 (2), 238-249, 2021 | 26 | 2021 |
| De novo synthesis of multisubstituted aryl amines using alkene cross metathesis MR Tatton, I Simpson, TJ Donohoe Organic letters 16 (7), 1920-1923, 2014 | 23 | 2014 |
Craig JamiesonSenior Lecturer, University of StrathclydeVerified email at strath.ac.uk
