ZA919296B - 2beta,19-ethylene bridged steroids as aromatase inhibitors - Google Patents

2beta,19-ethylene bridged steroids as aromatase inhibitors

Info

Publication number: ZA919296B
Authority: ZA; South Africa
Prior art keywords: aromatase inhibitors; 2beta; ethylene bridged; bridged steroids; steroids
Prior art date: 1990-11-30

Application number

ZA919296A

Other languages

English (en)

Inventor

John O'neal Johnston

O'neal Johnston John

Norton Paul Peet

Paul Peet Norton

Joseph Paul Burkhart

Paul Burkhart Joseph

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-30

Filing date

1991-11-25

Publication date

1992-08-26

1991-11-25 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1992-08-26 Publication of ZA919296B publication Critical patent/ZA919296B/xx

Links

239000003886 aromatase inhibitor Substances 0.000 title abstract 2
229940046844 aromatase inhibitors Drugs 0.000 title abstract 2
239000005977 Ethylene Substances 0.000 title 1
150000003431 steroids Chemical class 0.000 title 1
ORBBRLNBGBWXEF-OQWKOXFXSA-N 3-[(8r,9s,10r,13s,14s)-13-methyl-3,17-dioxo-2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-10-yl]propyl 4-methylbenzenesulfonate Chemical compound C1=CC(C)=CC=C1S(=O)(=O)OCCC[C@@]1([C@H]2CC[C@]3(C)C(=O)CC[C@H]3[C@@H]2CC2)C2=CC(=O)CC1 ORBBRLNBGBWXEF-OQWKOXFXSA-N 0.000 abstract 1
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical group C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
150000001441 androstanes Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000007363 ring formation reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Diabetes (AREA)
Gynecology & Obstetrics (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Bakery Products And Manufacturing Methods Therefor (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ZA919296A 1990-11-30 1991-11-25 2beta,19-ethylene bridged steroids as aromatase inhibitors ZA919296B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/621,184 US5166201A (en)	1990-11-30	1990-11-30	2β,19-ethylene bridged steroids as aromatase inhibitors

Publications (1)

Publication Number	Publication Date
ZA919296B true ZA919296B (en)	1992-08-26

Family

ID=24489093

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA919296A ZA919296B (en)	1990-11-30	1991-11-25	2beta,19-ethylene bridged steroids as aromatase inhibitors

Country Status (20)

Country	Link
US (1)	US5166201A (xx)
EP (1)	EP0488383B1 (xx)
JP (1)	JP3143876B2 (xx)
KR (1)	KR100190776B1 (xx)
CN (1)	CN1033975C (xx)
AT (1)	ATE142639T1 (xx)
AU (1)	AU635444B2 (xx)
CA (1)	CA2056638C (xx)
DE (1)	DE69122048T2 (xx)
DK (1)	DK0488383T3 (xx)
ES (1)	ES2094183T3 (xx)
FI (1)	FI102073B1 (xx)
GR (1)	GR3021981T3 (xx)
HU (1)	HU210830B (xx)
IE (1)	IE914168A1 (xx)
IL (1)	IL100196A (xx)
NO (1)	NO180304C (xx)
NZ (1)	NZ240738A (xx)
PT (1)	PT99661B (xx)
ZA (1)	ZA919296B (xx)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19510862A1 (de) *	1995-03-16	1996-09-19	Schering Ag	Verwendung von Antiestrogenen zur männlichen Fertilitätskontrolle
ATE473759T1 (de)	1998-05-22	2010-07-15	Univ Leland Stanford Junior	Bifunktionelle moleküle sowie darauf basierende therapien.
EP3827747A1 (en)	2005-04-28	2021-06-02	Otsuka Pharmaceutical Co., Ltd.	Pharma-informatics system
US9062126B2 (en)	2005-09-16	2015-06-23	Raptor Pharmaceuticals Inc.	Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
DK3395372T3 (da)	2009-02-20	2022-04-19	Enhanx Biopharm Inc	System til afgivelse af glutathion-baseret medikament
CN110075069A (zh)	2009-05-06	2019-08-02	实验室护肤股份有限公司	包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3627756A (en) *	1970-04-23	1971-12-14	Searle & Co	N-dialkylaminoalkyl-n-(2{62 ,19-epoxy-5{60 -androstan-17{62 -yl)amines/formamides and 3{60 -halo derivatives thereof
US4322416A (en) *	1980-06-27	1982-03-30	Merrell Dow Pharmaceuticals Inc.	10-Alkynyl steroids
GB8501035D0 (en) *	1985-01-16	1985-02-20	Senior J	Prostaglandins
US4882322A (en) *	1988-10-27	1989-11-21	Merrell Dow Pharmaceuticals Inc.	3β,17β-hydroxy-substituted steroids and related steroidal compounds

1990
- 1990-11-30 US US07/621,184 patent/US5166201A/en not_active Expired - Fee Related
1991
- 1991-11-25 ZA ZA919296A patent/ZA919296B/xx unknown
- 1991-11-25 AU AU88128/91A patent/AU635444B2/en not_active Ceased
- 1991-11-26 NZ NZ240738A patent/NZ240738A/xx unknown
- 1991-11-28 IL IL10019691A patent/IL100196A/en not_active IP Right Cessation
- 1991-11-28 FI FI915623A patent/FI102073B1/fi active IP Right Grant
- 1991-11-29 ES ES91120560T patent/ES2094183T3/es not_active Expired - Lifetime
- 1991-11-29 EP EP91120560A patent/EP0488383B1/en not_active Expired - Lifetime
- 1991-11-29 PT PT99661A patent/PT99661B/pt not_active IP Right Cessation
- 1991-11-29 NO NO914710A patent/NO180304C/no not_active IP Right Cessation
- 1991-11-29 HU HU913739A patent/HU210830B/hu not_active IP Right Cessation
- 1991-11-29 IE IE416891A patent/IE914168A1/en not_active Application Discontinuation
- 1991-11-29 CA CA002056638A patent/CA2056638C/en not_active Expired - Fee Related
- 1991-11-29 DK DK91120560.7T patent/DK0488383T3/da active
- 1991-11-29 AT AT91120560T patent/ATE142639T1/de not_active IP Right Cessation
- 1991-11-29 JP JP03339535A patent/JP3143876B2/ja not_active Expired - Fee Related
- 1991-11-29 DE DE69122048T patent/DE69122048T2/de not_active Expired - Fee Related
- 1991-11-30 KR KR1019910021920A patent/KR100190776B1/ko not_active Expired - Fee Related
- 1991-11-30 CN CN91111251A patent/CN1033975C/zh not_active Expired - Fee Related
1996
- 1996-12-11 GR GR960403414T patent/GR3021981T3/el unknown

Also Published As

Publication number	Publication date
DE69122048D1 (de)	1996-10-17
AU635444B2 (en)	1993-03-18
JPH04290898A (ja)	1992-10-15
CA2056638C (en)	2002-03-05
CN1033975C (zh)	1997-02-05
HUT59937A (en)	1992-07-28
IL100196A0 (en)	1992-08-18
ATE142639T1 (de)	1996-09-15
HU210830B (en)	1995-08-28
US5166201A (en)	1992-11-24
ES2094183T3 (es)	1997-01-16
EP0488383A1 (en)	1992-06-03
FI915623L (fi)	1992-05-31
GR3021981T3 (en)	1997-03-31
AU8812891A (en)	1992-06-04
CN1061974A (zh)	1992-06-17
HU913739D0 (en)	1992-02-28
NO180304B (no)	1996-12-16
FI915623A0 (fi)	1991-11-28
KR100190776B1 (ko)	1999-06-01
NO180304C (no)	1997-04-02
JP3143876B2 (ja)	2001-03-07
EP0488383B1 (en)	1996-09-11
FI102073B (fi)	1998-10-15
IL100196A (en)	1996-03-31
NO914710D0 (no)	1991-11-29
DE69122048T2 (de)	1997-02-20
NO914710L (no)	1992-06-01
KR920009842A (ko)	1992-06-25
PT99661B (pt)	1999-05-31
NZ240738A (en)	1993-11-25
DK0488383T3 (da)	1996-09-30
IE914168A1 (en)	1992-06-03
FI102073B1 (fi)	1998-10-15
PT99661A (pt)	1992-10-30
CA2056638A1 (en)	1992-05-31

Publication	Publication Date	Title
NO20002676D0 (no)	2000-05-25	Androgene steroidforbindelser og en fremgangsmÕte for fremstilling og anvendelse av samme
IL100196A0 (en)	1992-08-18	2beta,19-ethylene bridged steroids as aromatase inhibitors
DE68911157D1 (de)	1994-01-20	Synthese von 6-Methylenandrosta-1,4-dien-3,17-dion-Derivate.
BG103271A (en)	2000-05-31	Derivatives of n-(benzothiazol-2-yl) piperidine-1-ethaneamines, method for their preparation and application as therapeutical means
DK0559706T3 (da)	1997-09-08	2 beta,19-methylenamino-broforbundne steroider som aromataseinhibitorer.
BG103050A (en)	1999-10-29	New derivatives of erythromycin, method for their preparation and application as medicamentous forms
UA40574C2 (uk)	2001-08-15	Похідні 17,20-епоксипрегнану, спосіб їх одержання, спосіб одержання похідних кортизону і проміжні сполуки
HU9202100D0 (en)	1992-10-28	New 16-methyl-pregna-1,4-diene-3,20-dione derivatives
NZ237559A (en)	1993-04-28	Halogenoethyl steroid derivatives and pharmaceutical compositions
CA2032311A1 (en)	1991-06-21	2,19-methyleneoxy and 2,19-methylenethio bridged steroids as aromatase and 19-hydroxylase inhibitors
ES8604512A1 (es)	1986-02-01	Procedimiento para la obtencion de fenilhidrazonpirrolidinas substituidas
JPS52131580A (en)	1977-11-04	N-substituted pyridinium-2-sulfonylimines, containing same as active ingredient