ZA824453B - 1-aryl 2-aminomethyl cyclopropane carboxamide (z) derivatives their preparation and their use as useful drugs in the treatment of disturbances of the central nervous system - Google Patents
1-aryl 2-aminomethyl cyclopropane carboxamide (z) derivatives their preparation and their use as useful drugs in the treatment of disturbances of the central nervous systemInfo
- Publication number
- ZA824453B ZA824453B ZA824453A ZA824453A ZA824453B ZA 824453 B ZA824453 B ZA 824453B ZA 824453 A ZA824453 A ZA 824453A ZA 824453 A ZA824453 A ZA 824453A ZA 824453 B ZA824453 B ZA 824453B
- Authority
- ZA
- South Africa
- Prior art keywords
- aryl
- atom
- nervous system
- treatment
- central nervous
- Prior art date
Links
- 210000003169 central nervous system Anatomy 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8112312A FR2508035A1 (fr) | 1981-06-23 | 1981-06-23 | Derives d'aryl-1-aminomethyl-2 cyclopropanes carboxamides (z), leur preparation et leur application en tant que medicaments utiles dans le traitement des troubles du systeme nerveux central |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA824453B true ZA824453B (en) | 1983-04-27 |
Family
ID=9259785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA824453A ZA824453B (en) | 1981-06-23 | 1982-06-23 | 1-aryl 2-aminomethyl cyclopropane carboxamide (z) derivatives their preparation and their use as useful drugs in the treatment of disturbances of the central nervous system |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4478836A (xx) |
| EP (1) | EP0068999B1 (xx) |
| JP (1) | JPS584752A (xx) |
| AT (1) | ATE13422T1 (xx) |
| AU (1) | AU550774B2 (xx) |
| CA (1) | CA1202639A (xx) |
| DE (1) | DE3263734D1 (xx) |
| ES (1) | ES512842A0 (xx) |
| FR (1) | FR2508035A1 (xx) |
| LU (1) | LU90410I2 (xx) |
| ZA (1) | ZA824453B (xx) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2581060B1 (fr) * | 1985-04-25 | 1988-07-01 | Pf Medicament | Procede industriel d'obtention du midalcipran |
| FR2581059B1 (fr) * | 1985-04-25 | 1988-04-22 | Pf Medicament | Procede de preparation du chlorhydrate de phenyl-1 diethyl amino carbonyl-1 aminomethyl-2 cyclopropane (z) |
| EP0747348A4 (en) * | 1994-02-22 | 1999-07-07 | Asahi Chemical Ind | AMINOALKYLCYCLOPROPAN DERIVATIVES |
| CA2134038C (en) * | 1994-06-16 | 1997-06-03 | David Taiwai Wong | Potentiation of drug response |
| EP0714663A3 (en) | 1994-11-28 | 1997-01-15 | Lilly Co Eli | Potentiation of drug responses by serotonin 1A receptor antagonists |
| PT759299E (pt) * | 1995-08-16 | 2000-09-29 | Lilly Co Eli | Potenciacao da resposta de serotonina |
| FR2752732B1 (fr) * | 1996-08-28 | 1998-11-20 | Pf Medicament | Forme galenique a liberation prolongee de milnacipran |
| EP1434763B1 (en) * | 2001-10-12 | 2018-01-17 | Azevan Pharmaceuticals, Inc. | Beta-lactamyl vasopressin v1a antagonists |
| US6635675B2 (en) | 2001-11-05 | 2003-10-21 | Cypress Bioscience, Inc. | Method of treating chronic fatigue syndrome |
| US6602911B2 (en) * | 2001-11-05 | 2003-08-05 | Cypress Bioscience, Inc. | Methods of treating fibromyalgia |
| US20040034101A1 (en) * | 2001-11-05 | 2004-02-19 | Cypress Bioscience, Inc. | Treatment and prevention of depression secondary to pain (DSP) |
| CA2483093A1 (en) * | 2002-04-24 | 2003-11-06 | Cypress Bioscience, Inc. | Use of milnacipran or a pharmaceutically acceptable salt thereof for treating chronic low back pain |
| AU2003284342B2 (en) * | 2002-10-25 | 2009-03-05 | Collegium Pharmaceutical, Inc. | Stereoisomers of p-hydroxy-milnacipran, and methods of use thereof |
| FR2851163B1 (fr) | 2003-02-14 | 2007-04-27 | Utilisation de l'enantiomere dextrogyre du milnacipran pour la preparation d'un medicament | |
| SI1601349T1 (sl) * | 2003-02-14 | 2008-10-31 | Pf Medicament | Uporaba enantiomera milnaciprana za pripravo zdravila |
| WO2004091596A2 (en) * | 2003-04-18 | 2004-10-28 | Pharmacia & Upjohn Company Llc | Combination therapies for chronic obstructive pulmonary disease (copd) |
| AR045368A1 (es) * | 2003-08-15 | 2005-10-26 | Lundbeck & Co As H | Derivados de ciclopropilo como antagonistas del receptor nk3 |
| MXPA06001738A (es) | 2003-08-15 | 2006-05-12 | Lundbeck & Co As H | Derivados de ciclopropilo como antagonistas del receptor nk3. |
| JP5646126B2 (ja) | 2003-12-11 | 2014-12-24 | サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | 鎮静剤と神経伝達物質調節剤の併用、および睡眠の質の向上方法および鬱の治療方法 |
| CA2567249A1 (en) * | 2004-04-19 | 2006-10-05 | Jds Pharmaceuticals, Llc | Lithium combinations, and uses related thereto |
| JP4418717B2 (ja) * | 2004-06-24 | 2010-02-24 | 住友化学株式会社 | （ｚ）−１−フェニル−１−ジエチルアミノカルボニル−２−アミノメチルシクロプロパン塩酸塩の製造方法 |
| JP2008534504A (ja) | 2005-03-22 | 2008-08-28 | アゼヴァン ファーマスーティカルズ，インコーポレイテッド | 月経前障害を治療するためのβラクタミルアルカン酸 |
| AU2006239922A1 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | Benzofuranyl alkanamine derivatives and uses thereof as 5-HT2c agonists |
| PE20070093A1 (es) * | 2005-04-22 | 2007-02-07 | Wyeth Corp | Derivados dihidrobenzofuranos como moduladores del receptor 5-ht2c |
| GT200600164A (es) * | 2005-04-22 | 2007-03-14 | Derivados de dihidrobenzofuranos y usos de los mismos | |
| CA2611724C (en) | 2005-06-10 | 2014-07-29 | Pierre Fabre Medicament S.A. | Stabilized milnacipran formulation |
| US20070015138A1 (en) * | 2005-07-08 | 2007-01-18 | Braincells, Inc. | Methods for identifying agents and conditions that modulate neurogenesis |
| CN101268068B (zh) * | 2005-07-19 | 2015-12-02 | 阿泽范药品公司 | β-内酰胺基苯丙氨酸、半胱氨酸和丝氨酸血管加压素拮抗剂 |
| US20090203750A1 (en) * | 2005-08-24 | 2009-08-13 | Alan Kozikowski | 5-HT2C Receptor Agonists as Anorectic Agents |
| US7994220B2 (en) * | 2005-09-28 | 2011-08-09 | Cypress Bioscience, Inc. | Milnacipran for the long-term treatment of fibromyalgia syndrome |
| CA2625153A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20080319083A1 (en) * | 2006-01-27 | 2008-12-25 | Asahi Kasei Pharma Corporation | Medicine for transnasal administration |
| JPWO2007086493A1 (ja) * | 2006-01-27 | 2009-06-25 | 旭化成ファーマ株式会社 | 経鼻投与用薬剤 |
| FR2912057B1 (fr) * | 2007-02-07 | 2009-04-17 | Sanofi Aventis Sa | Composition pharmaceutique contenant en association le saredutant et un inhibiteur selectif de la recapture de la serotonine ou un inhibiteur de la recapture de la serotonine/norepinephrine |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| MX2008012094A (es) * | 2006-03-24 | 2008-10-03 | Wyeth Corp | Nuevas combinaciones terapeuticas para el tratamiento de la depresion. |
| JP2009536669A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス，インコーポレイティド | アンジオテンシン調節による神経新生 |
| US7678808B2 (en) | 2006-05-09 | 2010-03-16 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
| US7858611B2 (en) * | 2006-05-09 | 2010-12-28 | Braincells Inc. | Neurogenesis by modulating angiotensin |
| TW200817003A (en) * | 2006-07-31 | 2008-04-16 | Sanofi Aventis | Pharmaceutical composition comprising, in combination, saredutant and a selective serotonin peuptake inhibitor or a serotonin/norepinephrine reuptake inhibitor |
| AU2007292848A1 (en) | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US20100016274A1 (en) * | 2006-09-14 | 2010-01-21 | Koppel Gary A | Beta-lactam cannabinoid receptor modulators |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| US20080167363A1 (en) * | 2006-12-28 | 2008-07-10 | Braincells, Inc | Modulation of Neurogenesis By Melatoninergic Agents |
| AU2008204800A1 (en) * | 2007-01-11 | 2008-07-17 | Braincells, Inc. | Modulation of neurogenesis with use of modafinil |
| US20100145099A1 (en) * | 2007-02-28 | 2010-06-10 | Ranbaxy Laboratories Limited | Novel polymorphic forms of milnacipran hydrochloride |
| WO2009023820A1 (en) * | 2007-08-16 | 2009-02-19 | Cypress Biosciences, Inc. | Improving the tolerability of a serotonin antagonist and a nsri, a snri or a rima by using them in combination |
| US20090069431A1 (en) * | 2007-09-12 | 2009-03-12 | Protia, Llc | Deuterium-enriched milnacipran |
| US20110034565A1 (en) | 2008-04-18 | 2011-02-10 | University College Dublin, National University Of Ireland, Dublin | Psycho-pharmaceuticals |
| US20100092479A1 (en) * | 2008-08-18 | 2010-04-15 | Combinatorx (Singapore) Pte. Ltd. | Compositions and methods for treatment of viral diseases |
| WO2010036773A1 (en) * | 2008-09-24 | 2010-04-01 | Concert Pharmaceuticals, Inc. | Deuterated l-aryl-2 -aminomethyl cyclopropane carboxyamide derivatives |
| FR2941454B1 (fr) | 2009-01-29 | 2011-04-01 | Pf Medicament | Proced de synthese du (1s,2r)-milnacipran |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| US20100274050A1 (en) * | 2009-04-23 | 2010-10-28 | Glenmark Generics Limited | Solid milnacipran and process for the preparation of the same |
| WO2010129689A1 (en) * | 2009-05-05 | 2010-11-11 | Forest Laboratories Holdings Limited | Milnacipran formulations |
| WO2011016057A2 (en) | 2009-08-05 | 2011-02-10 | Lupin Limited | Controlled release pharmaceutical compositions of milnacipran |
| JP2013510176A (ja) | 2009-11-06 | 2013-03-21 | ピエール ファーブル メディカモン | （１ｓ，２ｒ）−２−（アミノメチル）−ｎ，ｎ−ジエチル−１−フェニルシクロプロパンカルボキサミドの新規結晶形態 |
| WO2011092065A1 (en) | 2010-01-29 | 2011-08-04 | Nicox S.A. | Nitric oxide releasing compounds for the treatment of neurophatic pain |
| ES2662350T3 (es) | 2010-07-01 | 2018-04-06 | Azevan Pharmaceuticals, Inc. | Procedimientos para el tratamiento del trastorno por estrés postraumático |
| US8916194B2 (en) | 2010-08-30 | 2014-12-23 | Lupin Limited | Controlled release pharmaceutical compositions of milnacipran |
| US20120289744A1 (en) | 2010-11-03 | 2012-11-15 | Arch Pharmalabs Limited | Process for preparing optically pure milnacipran and its pharmaceutically acceptable salts |
| EP2699539B1 (en) * | 2011-04-21 | 2019-03-06 | Emory University | Cyclopropyl derivatives and methods of use |
| WO2014009767A1 (en) | 2012-07-07 | 2014-01-16 | Micro Labs Limited | An improved process for the preparation of 1-aryl 2-aminomethyl cyclopropane carboxyamide (z) derivatives, their isomers and salts |
| WO2014203277A2 (en) * | 2013-06-19 | 2014-12-24 | Msn Laboratories Private Limited | Process for the preparation of (1s,2r)-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropanearboxamide hydrochloride |
| IN2013MU03122A (xx) | 2013-09-30 | 2015-07-17 | Cadila Healthcare Ltd | |
| KR20160130853A (ko) | 2014-03-28 | 2016-11-14 | 아제반 파마슈티칼스, 인코퍼레이티드 | 신경변성 질환을 치료하기 조성물 및 방법 |
| AU2018333051B2 (en) | 2017-09-15 | 2024-03-21 | Azevan Pharmaceuticals, Inc. | Compositions and methods for treating brain injury |
| JP7739256B2 (ja) | 2019-07-19 | 2025-09-16 | バイオエクセル セラピューティクス，インコーポレイテッド | 鎮静作用のないデクスメデトミジン治療レジメン |
| US11806334B1 (en) | 2023-01-12 | 2023-11-07 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA619080A (en) * | 1961-04-25 | The Upjohn Company | N-SUBSTITUTED-.alpha.-(TERTIARY-AMINOALKYL)-.alpha.-PHENYLACETAMIDES | |
| CA570688A (en) * | 1959-02-17 | E. Speeter Merrill | Antispasmodic substituted amines | |
| GB1415541A (en) | 1972-11-30 | 1975-11-26 | Hexachimie | 1-amino-methyl-2,2-diarylcyclopropanecarboxamide |
-
1981
- 1981-06-23 FR FR8112312A patent/FR2508035A1/fr active Granted
-
1982
- 1982-06-04 ES ES512842A patent/ES512842A0/es active Granted
- 1982-06-21 EP EP82401129A patent/EP0068999B1/fr not_active Expired
- 1982-06-21 AT AT82401129T patent/ATE13422T1/de active
- 1982-06-21 DE DE8282401129T patent/DE3263734D1/de not_active Expired
- 1982-06-22 AU AU85086/82A patent/AU550774B2/en not_active Expired
- 1982-06-22 CA CA000405651A patent/CA1202639A/fr not_active Expired
- 1982-06-22 US US06/390,810 patent/US4478836A/en not_active Expired - Lifetime
- 1982-06-23 JP JP57109097A patent/JPS584752A/ja active Granted
- 1982-06-23 ZA ZA824453A patent/ZA824453B/xx unknown
-
1999
- 1999-06-30 LU LU90410C patent/LU90410I2/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES8303293A1 (es) | 1983-03-01 |
| FR2508035A1 (fr) | 1982-12-24 |
| ES512842A0 (es) | 1983-03-01 |
| EP0068999A1 (fr) | 1983-01-05 |
| CA1202639A (fr) | 1986-04-01 |
| AU550774B2 (en) | 1986-04-10 |
| FR2508035B1 (xx) | 1984-06-29 |
| AU8508682A (en) | 1983-01-06 |
| JPS6323186B2 (xx) | 1988-05-16 |
| DE3263734D1 (en) | 1985-06-27 |
| LU90410I2 (fr) | 1999-08-31 |
| ATE13422T1 (de) | 1985-06-15 |
| US4478836A (en) | 1984-10-23 |
| EP0068999B1 (fr) | 1985-05-22 |
| JPS584752A (ja) | 1983-01-11 |
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