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ZA200901551B - 2-aryl-6-phenylimidazo[1,2-alpha]pyridine derivatives, preparation thereof and therapeutic use thereof - Google Patents

2-aryl-6-phenylimidazo[1,2-alpha]pyridine derivatives, preparation thereof and therapeutic use thereof

Info

Publication number
ZA200901551B
ZA200901551B ZA200901551A ZA200901551A ZA200901551B ZA 200901551 B ZA200901551 B ZA 200901551B ZA 200901551 A ZA200901551 A ZA 200901551A ZA 200901551 A ZA200901551 A ZA 200901551A ZA 200901551 B ZA200901551 B ZA 200901551B
Authority
ZA
South Africa
Prior art keywords
phenylimidazo
aryl
alpha
preparation
therapeutic use
Prior art date
Application number
ZA200901551A
Other languages
English (en)
Inventor
Garcia Antonio Almario
Patrick Lardenois
Anne Olivier
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of ZA200901551B publication Critical patent/ZA200901551B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA200901551A 2006-09-22 2007-09-19 2-aryl-6-phenylimidazo[1,2-alpha]pyridine derivatives, preparation thereof and therapeutic use thereof ZA200901551B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0608350A FR2906250B1 (fr) 2006-09-22 2006-09-22 Derives de 2-aryl-6phenyl-imidazo(1,2-a) pyridines, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
ZA200901551B true ZA200901551B (en) 2010-06-30

Family

ID=37841968

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200901551A ZA200901551B (en) 2006-09-22 2007-09-19 2-aryl-6-phenylimidazo[1,2-alpha]pyridine derivatives, preparation thereof and therapeutic use thereof

Country Status (43)

Country Link
US (1) US7915284B2 (xx)
EP (1) EP2069342B1 (xx)
JP (1) JP5336378B2 (xx)
KR (1) KR101470039B1 (xx)
CN (1) CN101516881B (xx)
AR (1) AR062897A1 (xx)
AT (1) ATE467633T1 (xx)
AU (1) AU2007298856B2 (xx)
BR (1) BRPI0718517A2 (xx)
CA (1) CA2662848C (xx)
CL (1) CL2007002733A1 (xx)
CO (1) CO6160308A2 (xx)
CR (1) CR10643A (xx)
CY (1) CY1110232T1 (xx)
DE (1) DE602007006525D1 (xx)
DK (1) DK2069342T3 (xx)
EA (1) EA017442B1 (xx)
ES (1) ES2345016T3 (xx)
FR (1) FR2906250B1 (xx)
GT (1) GT200900049A (xx)
HN (1) HN2009000502A (xx)
HR (1) HRP20100408T1 (xx)
IL (1) IL197352A (xx)
JO (1) JO2643B1 (xx)
MA (1) MA30792B1 (xx)
ME (1) ME00615B (xx)
MX (1) MX2009002802A (xx)
MY (1) MY145603A (xx)
NI (1) NI200900037A (xx)
NO (1) NO20091562L (xx)
NZ (1) NZ575337A (xx)
PE (1) PE20080671A1 (xx)
PL (1) PL2069342T3 (xx)
PT (1) PT2069342E (xx)
RS (1) RS51412B (xx)
SI (1) SI2069342T1 (xx)
SV (1) SV2009003193A (xx)
TN (1) TN2009000081A1 (xx)
TW (1) TWI381837B (xx)
UA (1) UA95976C2 (xx)
UY (1) UY30603A1 (xx)
WO (1) WO2008034974A1 (xx)
ZA (1) ZA200901551B (xx)

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FR2928922B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines polysubstitues, leur preparation et leur application en therapeutique
FR2928924B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique
FR2928923B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques
FR2928921B1 (fr) 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines, leur preparation et leur application en therapeutique
FR2933609B1 (fr) * 2008-07-10 2010-08-27 Fournier Lab Sa Utilisation de derives d'indole comme activateurs de nurr-1, pour le traitement de la maladie de parkinson.
FR2950345B1 (fr) * 2009-09-18 2011-09-23 Sanofi Aventis Derives acetyleniques de 5-phenyl-pyrazolopyridine, leur preparation et leur application en therapeutique
FR2950344B1 (fr) * 2009-09-18 2011-11-25 Sanofi Aventis Derives de 5-phenyl-pyrazolopyridine, leur preparation et leur aplication en therapeutique.
FR2953520B1 (fr) * 2009-12-04 2011-11-25 Sanofi Aventis Derives de diphenyl-pyrazolopyridines, leur preparation et leur application en therapeutique
JP6007339B2 (ja) * 2012-11-29 2016-10-12 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ イミダゾピリジン誘導体
TWI644899B (zh) 2013-02-04 2018-12-21 健生藥品公司 Ｆｌａｐ調節劑
EP3070085B1 (en) 2013-02-04 2019-01-09 Janssen Pharmaceutica NV Flap modulators
DK3027615T3 (da) * 2013-08-02 2021-10-25 Pasteur Institut Korea Antiinfektionsforbindelser
KR20170137165A (ko) 2015-04-10 2017-12-12 베이진 엘티디 인돌아민 및/또는 트립토판 2,3-디옥시게나아제로서 신규한 5 또는 8-치환된 이미다조[1,5-a]피리딘
EP3365340B1 (en) 2015-10-19 2022-08-10 Incyte Corporation Heterocyclic compounds as immunomodulators
HUE060680T2 (hu) 2015-11-19 2023-04-28 Incyte Corp Heterociklusos vegyületek mint immunmodulátorok
EP3394033B1 (en) 2015-12-22 2020-11-25 Incyte Corporation Heterocyclic compounds as immunomodulators
WO2017192961A1 (en) 2016-05-06 2017-11-09 Incyte Corporation Heterocyclic compounds as immunomodulators
TW201808902A (zh) 2016-05-26 2018-03-16 美商英塞特公司 作為免疫調節劑之雜環化合物
MD3472167T2 (ro) 2016-06-20 2023-02-28 Incyte Corp Compuși heterociclici ca imunomodulatori
WO2018013789A1 (en) 2016-07-14 2018-01-18 Incyte Corporation Heterocyclic compounds as immunomodulators
US20180057486A1 (en) 2016-08-29 2018-03-01 Incyte Corporation Heterocyclic compounds as immunomodulators
CN109952300B (zh) 2016-09-24 2022-01-18 百济神州有限公司 5或8-取代的咪唑并[1,5-a]吡啶
PE20200005A1 (es) 2016-12-22 2020-01-06 Incyte Corp Derivados de tetrahidro imidazo[4,5-c]piridina como inductores de internalizacion pd-l1
EP3558973B1 (en) 2016-12-22 2021-09-15 Incyte Corporation Pyridine derivatives as immunomodulators
EP3558963B1 (en) 2016-12-22 2022-03-23 Incyte Corporation Bicyclic heteroaromatic compounds as immunomodulators
MA47123A (fr) 2016-12-22 2021-03-17 Incyte Corp Dérivés de benzooxazole en tant qu'mmunomodulateurs
EP3558989B1 (en) 2016-12-22 2021-04-14 Incyte Corporation Triazolo[1,5-a]pyridine derivatives as immunomodulators
CN111386114A (zh) 2017-11-25 2020-07-07 百济神州有限公司 作为吲哚胺2,3-双加氧酶的选择性抑制剂的新颖苯并咪唑
PL4212529T3 (pl) 2018-03-30 2025-07-07 Incyte Corporation Związki heterocykliczne jako immunomodulatory
HRP20230306T1 (hr) 2018-05-11 2023-05-12 Incyte Corporation Derivati tetrahidro-imidazo[4,5-c]piridina kao pd-l1 imunomodulatori
WO2021030162A1 (en) 2019-08-09 2021-02-18 Incyte Corporation Salts of a pd-1/pd-l1 inhibitor
IL291471B2 (en) 2019-09-30 2025-04-01 Incyte Corp Pyrimido[3,2–D]pyrimidine compounds as immunomodulators
CR20220237A (es) 2019-11-11 2022-08-05 Incyte Corp Sales y formas cristalinas de un inhibidor de pd-1/pd-l1
KR20220100921A (ko) * 2019-11-13 2022-07-18 아프리노이아 테라퓨틱스 리미티드 타우 단백질 응집체를 분해하기 위한 화합물 및 이의 용도
AR124001A1 (es) 2020-11-06 2023-02-01 Incyte Corp Proceso para fabricar un inhibidor pd-1 / pd-l1 y sales y formas cristalinas del mismo
US11780836B2 (en) 2020-11-06 2023-10-10 Incyte Corporation Process of preparing a PD-1/PD-L1 inhibitor
WO2022099075A1 (en) 2020-11-06 2022-05-12 Incyte Corporation Crystalline form of a pd-1/pd-l1 inhibitor

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WO2001074813A2 (en) * 2000-03-31 2001-10-11 Ortho Mcneil Pharmaceutical, Inc. METHOD FOR USING 2- OR 3-ARYL SUBSTITUTED IMIDAZO[1,2-a] PYRIDINES AS H3 ANTAGONISTS
GB0119911D0 (en) * 2001-08-15 2001-10-10 Novartis Ag Organic Compounds
CA2499639C (en) * 2002-09-19 2011-11-08 Schering Corporation Imidazopyridines as cyclin dependent kinase inhibitors
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EP1745045A4 (en) * 2004-03-08 2009-07-22 Univ North Carolina NEW DIKATIONIC IMIDAZO [1,2-A] PYRIDINES AND 5,6,7,8-TETRAHYDROIMIDAZO [1,2-A] PYRIDINES AS AGENTS AGAINST PROTOZOES

Also Published As

Publication number Publication date
EP2069342B1 (fr) 2010-05-12
HK1135388A1 (en) 2010-06-04
BRPI0718517A2 (pt) 2013-11-19
EP2069342A1 (fr) 2009-06-17
JP2010504309A (ja) 2010-02-12
PE20080671A1 (es) 2008-07-14
UA95976C2 (xx) 2011-09-26
KR20090054449A (ko) 2009-05-29
TN2009000081A1 (en) 2010-08-19
UY30603A1 (es) 2008-05-02
NI200900037A (es) 2014-02-20
CL2007002733A1 (es) 2008-04-11
DK2069342T3 (da) 2010-08-23
MEP10709A (en) 2011-12-20
SI2069342T1 (sl) 2010-09-30
CA2662848C (fr) 2014-12-23
MX2009002802A (es) 2009-04-01
CO6160308A2 (es) 2010-05-20
ATE467633T1 (de) 2010-05-15
CA2662848A1 (fr) 2008-03-27
PL2069342T3 (pl) 2010-10-29
HRP20100408T1 (hr) 2010-09-30
MA30792B1 (fr) 2009-10-01
HN2009000502A (es) 2011-07-11
GT200900049A (es) 2010-03-04
ES2345016T3 (es) 2010-09-13
MY145603A (en) 2012-03-15
FR2906250B1 (fr) 2008-10-31
CR10643A (es) 2009-04-29
AR062897A1 (es) 2008-12-10
EA200970311A1 (ru) 2009-08-28
AU2007298856B2 (en) 2012-08-09
JO2643B1 (en) 2012-06-17
IL197352A0 (en) 2009-12-24
IL197352A (en) 2014-11-30
TW200833329A (en) 2008-08-16
EA017442B1 (ru) 2012-12-28
FR2906250A1 (fr) 2008-03-28
KR101470039B1 (ko) 2014-12-05
NO20091562L (no) 2009-04-20
US20090253735A1 (en) 2009-10-08
CN101516881A (zh) 2009-08-26
TWI381837B (zh) 2013-01-11
CN101516881B (zh) 2012-07-18
JP5336378B2 (ja) 2013-11-06
PT2069342E (pt) 2010-07-19
NZ575337A (en) 2011-12-22
DE602007006525D1 (de) 2010-06-24
US7915284B2 (en) 2011-03-29
ME00615B (me) 2011-12-20
WO2008034974A1 (fr) 2008-03-27
AU2007298856A1 (en) 2008-03-27
CY1110232T1 (el) 2015-01-14
RS51412B (sr) 2011-02-28
SV2009003193A (es) 2010-02-01

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