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ZA200904676B - Modulators of sclerostin binding partners for treating bonerelated disorders - Google Patents

Modulators of sclerostin binding partners for treating bonerelated disorders

Info

Publication number
ZA200904676B
ZA200904676B ZA200904676A ZA200904676A ZA200904676B ZA 200904676 B ZA200904676 B ZA 200904676B ZA 200904676 A ZA200904676 A ZA 200904676A ZA 200904676 A ZA200904676 A ZA 200904676A ZA 200904676 B ZA200904676 B ZA 200904676B
Authority
ZA
South Africa
Prior art keywords
bonerelated
modulators
disorders
treating
binding partners
Prior art date
Application number
ZA200904676A
Other languages
English (en)
Inventor
Chris Xiangyang Lu
Shou-Lh Hu
Michaela Kneissel
Christine Halleux
Original Assignee
Novertis A G
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novertis A G filed Critical Novertis A G
Publication of ZA200904676B publication Critical patent/ZA200904676B/xx

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
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    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
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ZA200904676A 2007-02-02 2009-07-03 Modulators of sclerostin binding partners for treating bonerelated disorders ZA200904676B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US88795607P 2007-02-02 2007-02-02

Publications (1)

Publication Number Publication Date
ZA200904676B true ZA200904676B (en) 2010-04-28

Family

ID=39298321

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200904676A ZA200904676B (en) 2007-02-02 2009-07-03 Modulators of sclerostin binding partners for treating bonerelated disorders

Country Status (16)

Country Link
US (3) US20100028335A1 (fr)
EP (1) EP2114435A1 (fr)
JP (1) JP2010526766A (fr)
KR (1) KR20090115133A (fr)
CN (1) CN101616684A (fr)
AU (1) AU2008209713B2 (fr)
BR (1) BRPI0807205A2 (fr)
CA (1) CA2675639A1 (fr)
EA (1) EA200901031A1 (fr)
IL (1) IL199834A0 (fr)
MA (1) MA31156B1 (fr)
MX (1) MX2009008096A (fr)
NZ (1) NZ578235A (fr)
TN (1) TN2009000323A1 (fr)
WO (1) WO2008092894A1 (fr)
ZA (1) ZA200904676B (fr)

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EA015166B1 (ru) 2003-06-16 2011-06-30 Ю-Си-Би Мэньюфэкчуринг, Инк. Иммуногенные пептиды склеростина (sost), индуцирующие образование специфических антител
US8003108B2 (en) 2005-05-03 2011-08-23 Amgen Inc. Sclerostin epitopes
US7592429B2 (en) 2005-05-03 2009-09-22 Ucb Sa Sclerostin-binding antibody
US8541177B2 (en) * 2006-01-13 2013-09-24 A Chan Holding B.V. Treatment and diagnosis of abnormal bone density with an inhibitor of the glypican-sclerostin interaction
US8470966B2 (en) 2007-08-10 2013-06-25 Protelica, Inc. Universal fibronectin type III binding-domain libraries
WO2009023184A2 (fr) * 2007-08-10 2009-02-19 Protelix, Inc. Bibliothèques universelles de domaines de liaison de la fibronectine de type iii
US8680019B2 (en) * 2007-08-10 2014-03-25 Protelica, Inc. Universal fibronectin Type III binding-domain libraries
CL2008002775A1 (es) 2007-09-17 2008-11-07 Amgen Inc Uso de un agente de unión a esclerostina para inhibir la resorción ósea.
US8715941B2 (en) 2007-11-16 2014-05-06 Arca Biopharma, Inc. Antibodies to LRP6
CA2748500C (fr) * 2009-01-29 2017-10-17 Commonwealth Scientific And Industrial Research Organisation Mesure de l'activation d'un recepteur couple aux proteines g
SMT202000095T1 (it) 2010-05-14 2020-03-13 Amgen Inc Formulazioni di anticorpi anti-sclerostina ad alta concentrazione
US8614190B2 (en) 2010-06-30 2013-12-24 Industrial Technology Research Institute Thermal responsive composition for treating bone diseases
EP2412724A1 (fr) * 2010-07-29 2012-02-01 Centre National de la Recherche Scientifique (C.N.R.S) Régulation de l'activité 4 glypican pour moduler le sort de cellules souches et leurs utilisations
HUE044038T2 (hu) 2010-11-05 2019-09-30 Novartis Ag Spondilitisz ankilopoetika kezelési eljárásai anti-IL-17 alkalmazásával
US9133272B2 (en) 2011-03-01 2015-09-15 Amgen Inc. Bispecific binding agents
AU2012236962B2 (en) 2011-03-25 2017-05-11 Amgen Inc. Anti-sclerostin antibody crystals and formulations thereof
RS60835B1 (sr) 2011-04-19 2020-10-30 Amgen Inc Metoda za lečenje osteoporoze
EP2702408A1 (fr) 2011-04-29 2014-03-05 Novartis AG Méthodes de traitement du carcinome épidermoïde et applications associées
ES2667554T3 (es) 2011-08-04 2018-05-11 Amgen Inc. Método para el tratamiento de los defectos de espacio óseo
AU2012362898B2 (en) 2011-12-28 2017-11-09 Amgen, Inc. Method of treating alveolar bone loss through the use of anti-sclerostin antibodies
US9925260B2 (en) 2012-07-05 2018-03-27 Ucb Pharma S.A. Treatment for bone diseases
UY35148A (es) 2012-11-21 2014-05-30 Amgen Inc Immunoglobulinas heterodiméricas
WO2014118705A1 (fr) 2013-01-31 2014-08-07 Novartis Ag Procédé de traitement des troubles minéraux et osseux de la maladie rénale chronique en utilisant des antagonistes de la sclérostine
WO2014144817A2 (fr) * 2013-03-15 2014-09-18 Amgen Inc. Polypeptides inhibiteurs spécifiques à des inhibiteurs wnt
WO2014155278A2 (fr) 2013-03-26 2014-10-02 Novartis Ag Méthodes de traitement de maladies auto-immunes à l'aide d'antagonistes de l'il -17
WO2015034330A1 (fr) * 2013-09-09 2015-03-12 가톨릭대학교 산학협력단 Composition pour le traitement ou la prévention de maladies osseuses, comprenant de l'halofuginone comme principe actif
WO2015098112A1 (fr) * 2013-12-27 2015-07-02 独立行政法人医薬基盤研究所 Marqueur du cancer de l'œsophage et utilisation associée
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EA200901031A1 (ru) 2010-04-30
US20130164284A1 (en) 2013-06-27
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NZ578235A (en) 2012-05-25
AU2008209713A1 (en) 2008-08-07
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IL199834A0 (en) 2010-04-15
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US20100028335A1 (en) 2010-02-04
CN101616684A (zh) 2009-12-30
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