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TN2009000323A1 - Modulators of sclerostin binding partners for treating bone-related disorders - Google Patents

Modulators of sclerostin binding partners for treating bone-related disorders

Info

Publication number
TN2009000323A1
TN2009000323A1 TNP2009000323A TN2009000323A TN2009000323A1 TN 2009000323 A1 TN2009000323 A1 TN 2009000323A1 TN P2009000323 A TNP2009000323 A TN P2009000323A TN 2009000323 A TN2009000323 A TN 2009000323A TN 2009000323 A1 TN2009000323 A1 TN 2009000323A1
Authority
TN
Tunisia
Prior art keywords
sclerostin
related disorders
modulators
binding partners
treating bone
Prior art date
Application number
TNP2009000323A
Other languages
English (en)
Inventor
Chris Xiangyang Lu
Shou-Ih Hu
Michaela Kneissel
Christine Halleux
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of TN2009000323A1 publication Critical patent/TN2009000323A1/fr

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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
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TNP2009000323A 2007-02-02 2009-07-31 Modulators of sclerostin binding partners for treating bone-related disorders TN2009000323A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88795607P 2007-02-02 2007-02-02
PCT/EP2008/051128 WO2008092894A1 (fr) 2007-02-02 2008-01-30 Modulateurs de partenaires de liaison de la sclérostine pour traiter des troubles liés aux os

Publications (1)

Publication Number Publication Date
TN2009000323A1 true TN2009000323A1 (en) 2010-12-31

Family

ID=39298321

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2009000323A TN2009000323A1 (en) 2007-02-02 2009-07-31 Modulators of sclerostin binding partners for treating bone-related disorders

Country Status (16)

Country Link
US (3) US20100028335A1 (fr)
EP (1) EP2114435A1 (fr)
JP (1) JP2010526766A (fr)
KR (1) KR20090115133A (fr)
CN (1) CN101616684A (fr)
AU (1) AU2008209713B2 (fr)
BR (1) BRPI0807205A2 (fr)
CA (1) CA2675639A1 (fr)
EA (1) EA200901031A1 (fr)
IL (1) IL199834A0 (fr)
MA (1) MA31156B1 (fr)
MX (1) MX2009008096A (fr)
NZ (1) NZ578235A (fr)
TN (1) TN2009000323A1 (fr)
WO (1) WO2008092894A1 (fr)
ZA (1) ZA200904676B (fr)

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US8003108B2 (en) 2005-05-03 2011-08-23 Amgen Inc. Sclerostin epitopes
US7592429B2 (en) 2005-05-03 2009-09-22 Ucb Sa Sclerostin-binding antibody
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WO2009064944A2 (fr) 2007-11-16 2009-05-22 Nuvelo, Inc. Anticorps dirigés contre lrp6
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EP2412724A1 (fr) * 2010-07-29 2012-02-01 Centre National de la Recherche Scientifique (C.N.R.S) Régulation de l'activité 4 glypican pour moduler le sort de cellules souches et leurs utilisations
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US9145457B2 (en) 2011-03-25 2015-09-29 Amgen Inc. Sclerostin antibody crystals and formulations thereof
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US9708375B2 (en) * 2013-03-15 2017-07-18 Amgen Inc. Inhibitory polypeptides specific to WNT inhibitors
WO2014155278A2 (fr) 2013-03-26 2014-10-02 Novartis Ag Méthodes de traitement de maladies auto-immunes à l'aide d'antagonistes de l'il -17
WO2015034330A1 (fr) * 2013-09-09 2015-03-12 가톨릭대학교 산학협력단 Composition pour le traitement ou la prévention de maladies osseuses, comprenant de l'halofuginone comme principe actif
WO2015098112A1 (fr) * 2013-12-27 2015-07-02 独立行政法人医薬基盤研究所 Marqueur du cancer de l'œsophage et utilisation associée
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MA31156B1 (fr) 2010-02-01
US20100028335A1 (en) 2010-02-04
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MX2009008096A (es) 2009-08-07
BRPI0807205A2 (pt) 2014-07-22
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JP2010526766A (ja) 2010-08-05
US20130164284A1 (en) 2013-06-27
CN101616684A (zh) 2009-12-30
AU2008209713A1 (en) 2008-08-07
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