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EA200701471A1 - Замещённые пиридинильные и пиримидинильные производные, используемые в качестве модуляторов метаболизма и лечение ассоциированных с ним расстройств - Google Patents

Замещённые пиридинильные и пиримидинильные производные, используемые в качестве модуляторов метаболизма и лечение ассоциированных с ним расстройств

Info

Publication number
EA200701471A1
EA200701471A1 EA200701471A EA200701471A EA200701471A1 EA 200701471 A1 EA200701471 A1 EA 200701471A1 EA 200701471 A EA200701471 A EA 200701471A EA 200701471 A EA200701471 A EA 200701471A EA 200701471 A1 EA200701471 A1 EA 200701471A1
Authority
EA
Eurasian Patent Office
Prior art keywords
modulators
treatment
substituted pyridinyl
disorders associated
metabolic disease
Prior art date
Application number
EA200701471A
Other languages
English (en)
Other versions
EA015714B1 (ru
Inventor
Роберт М. Джоунз
Юэрг Леманн
Эми Сиу-Тинг Вонг
Дэвид Херст
Янг-Дзун Шин
Original Assignee
Арена Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Арена Фармасьютикалз, Инк. filed Critical Арена Фармасьютикалз, Инк.
Publication of EA200701471A1 publication Critical patent/EA200701471A1/ru
Publication of EA015714B1 publication Critical patent/EA015714B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к некоторым замещенным пиридинильным и пиримидинильным производным формулы (Ia), которые являются модуляторами метаболизма. В соответствии с этим, соединения согласно изобретению могут быть использованы для лечения метаболических расстройств и их осложнений, таких как диабет и ожирение.
EA200701471A 2005-01-10 2006-01-09 Замещённые пиридинильные и пиримидинильные производные, используемые в качестве модуляторов метаболизма, и лечение ассоциированных с ним рассройств EA015714B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64284005P 2005-01-10 2005-01-10
PCT/US2006/000567 WO2006083491A2 (en) 2005-01-10 2006-01-09 Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto

Publications (2)

Publication Number Publication Date
EA200701471A1 true EA200701471A1 (ru) 2008-02-28
EA015714B1 EA015714B1 (ru) 2011-10-31

Family

ID=36755755

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200701471A EA015714B1 (ru) 2005-01-10 2006-01-09 Замещённые пиридинильные и пиримидинильные производные, используемые в качестве модуляторов метаболизма, и лечение ассоциированных с ним рассройств

Country Status (36)

Country Link
US (3) US20060155128A1 (ru)
EP (2) EP1911756B9 (ru)
JP (1) JP2008526882A (ru)
KR (1) KR20070098907A (ru)
CN (2) CN102125555A (ru)
AR (1) AR054320A1 (ru)
AT (2) ATE446293T1 (ru)
AU (1) AU2006211583C1 (ru)
BR (1) BRPI0606704A (ru)
CA (1) CA2594466A1 (ru)
CR (1) CR9225A (ru)
CY (2) CY1107215T1 (ru)
DE (2) DE602006009946D1 (ru)
DK (2) DK1732562T3 (ru)
EA (1) EA015714B1 (ru)
ES (2) ES2333824T4 (ru)
GE (1) GEP20094828B (ru)
GT (1) GT200600006A (ru)
HN (2) HN2006000969A (ru)
HR (2) HRP20080113T3 (ru)
IL (1) IL184363A0 (ru)
MX (1) MX2007008402A (ru)
MY (1) MY148521A (ru)
NI (1) NI200700169A (ru)
NO (1) NO20073806L (ru)
NZ (1) NZ556220A (ru)
PE (2) PE20091590A1 (ru)
PL (2) PL1732562T3 (ru)
PT (2) PT1732562E (ru)
RS (2) RS51007B (ru)
SG (1) SG158875A1 (ru)
SI (2) SI1732562T1 (ru)
TW (1) TW200637845A (ru)
UA (1) UA89812C2 (ru)
WO (1) WO2006083491A2 (ru)
ZA (1) ZA200705471B (ru)

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PE20060857A1 (es) 2006-09-02
ATE446293T1 (de) 2009-11-15
CA2594466A1 (en) 2006-08-10
EP1911756A2 (en) 2008-04-16
HN2010000430A (es) 2012-03-26
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GT200600006A (es) 2006-08-23
AR054320A1 (es) 2007-06-20
SG158875A1 (en) 2010-02-26
US8362248B2 (en) 2013-01-29
BRPI0606704A (pt) 2008-03-11
EP1732562B1 (en) 2007-12-19
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RS50540B (sr) 2010-05-07
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ES2299167T4 (es) 2011-02-18
DE602006000339T2 (de) 2009-01-22
WO2006083491A2 (en) 2006-08-10
CN101115740A (zh) 2008-01-30
DK1911756T3 (da) 2010-02-08
SI1911756T1 (sl) 2010-02-26
PL1911756T3 (pl) 2010-03-31
ATE381558T1 (de) 2008-01-15
US20070167473A1 (en) 2007-07-19
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AU2006211583C1 (en) 2011-09-08
DK1732562T3 (da) 2008-04-28
CY1109696T1 (el) 2014-08-13
NO20073806L (no) 2007-09-27
PT1911756E (pt) 2009-12-22
EP1732562A2 (en) 2006-12-20
HK1094542A1 (en) 2007-04-04
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EA015714B1 (ru) 2011-10-31
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