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ZA200805353B - Aryl-isoxazol-4-yl-imidazole derivatives - Google Patents

Aryl-isoxazol-4-yl-imidazole derivatives

Info

Publication number
ZA200805353B
ZA200805353B ZA200805353A ZA200805353A ZA200805353B ZA 200805353 B ZA200805353 B ZA 200805353B ZA 200805353 A ZA200805353 A ZA 200805353A ZA 200805353 A ZA200805353 A ZA 200805353A ZA 200805353 B ZA200805353 B ZA 200805353B
Authority
ZA
South Africa
Prior art keywords
isoxazol
aryl
imidazole derivatives
imidazole
derivatives
Prior art date
Application number
ZA200805353A
Other languages
English (en)
Inventor
Buettelmann Bernd
Han Bo
Knust Henner
Thomas Andrew
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ZA200805353B publication Critical patent/ZA200805353B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
ZA200805353A 2005-12-27 2008-06-19 Aryl-isoxazol-4-yl-imidazole derivatives ZA200805353B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05113011 2005-12-27

Publications (1)

Publication Number Publication Date
ZA200805353B true ZA200805353B (en) 2009-10-28

Family

ID=38218337

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200805353A ZA200805353B (en) 2005-12-27 2008-06-19 Aryl-isoxazol-4-yl-imidazole derivatives

Country Status (20)

Country Link
US (1) US7414061B2 (xx)
EP (1) EP1968973B1 (xx)
JP (1) JP2009521516A (xx)
KR (1) KR101121372B1 (xx)
CN (1) CN101351461B (xx)
AR (1) AR058760A1 (xx)
AT (1) ATE527255T1 (xx)
AU (1) AU2006331437B2 (xx)
BR (1) BRPI0620773A2 (xx)
CA (1) CA2633367A1 (xx)
DK (1) DK1968973T3 (xx)
ES (1) ES2371935T3 (xx)
IL (1) IL192235A0 (xx)
NO (1) NO20082747L (xx)
PL (1) PL1968973T3 (xx)
PT (1) PT1968973E (xx)
RU (1) RU2425045C2 (xx)
TW (1) TWI324998B (xx)
WO (1) WO2007074078A2 (xx)
ZA (1) ZA200805353B (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2090570B1 (en) 2006-09-05 2011-11-09 Kyowa Hakko Kirin Co., Ltd. Imidazole derivative
ES2369805T3 (es) * 2007-06-22 2011-12-07 F. Hoffmann-La Roche Ag Derivados de isoxazol-imidazol.
KR20120102117A (ko) 2007-12-04 2012-09-17 에프. 호프만-라 로슈 아게 아이속사졸로-피리딘 유도체
TW201033201A (en) * 2009-02-19 2010-09-16 Hoffmann La Roche Isoxazole-isoxazole and isoxazole-isothiazole derivatives
US8466181B2 (en) * 2010-12-10 2013-06-18 Hoffmann-La Roche Inc. 1,2,3-triazole-imidazole compounds
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
WO2014001278A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
WO2014001279A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
JP6223443B2 (ja) 2012-06-26 2017-11-01 サニオナ・エイピイエス フェニルトリアゾール誘導体及びｇａｂａａ受容体複合体を調節するための該フェニルトリアゾール誘導体の使用
JP6224097B2 (ja) 2012-06-26 2017-11-01 サニオナ・エイピイエス フェニルトリアゾール誘導体及びｇａｂａａ受受容体複合体を調節するための該フェニルトリアゾール誘導体の使用
WO2014001280A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
CN104703981B (zh) * 2012-10-01 2017-03-29 霍夫曼-拉罗奇有限公司 作为cns活性药剂的苯并咪唑类化合物
BR102019014802A2 (pt) 2018-07-20 2020-02-04 Boehringer Ingelheim Int difluorometil-fenil triazóis

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4112451A1 (de) * 1991-04-12 1992-10-15 Schering Ag Isoxazolylimidazolderivate, verfahren zu deren herstellung und deren verwendung in arzneimitteln
DE69902754T2 (de) * 1998-02-09 2003-08-07 3-Dimensional Pharmaceuticals, Inc. Heteroaryl-amidinen,-methylamidinen und -guanidinen als protease inhibitoren, insbesondere als urokinase inhibitoren
IT1314191B1 (it) 1999-10-18 2002-12-06 Recordati Chem Pharm Derivati isossazolcarbossamidici
PA8535601A1 (es) 2000-12-21 2002-11-28 Pfizer Derivados benzimidazol y piridilimidazol como ligandos para gabaa
GB0108475D0 (en) 2001-04-04 2001-05-23 Merck Sharp & Dohme New compounds
EA005934B1 (ru) 2001-07-05 2005-08-25 Х. Лундбекк А/С Замещённые анилиновые пиперидины в качестве селективных антагонистов мсн
GB0128160D0 (en) * 2001-11-23 2002-01-16 Merck Sharp & Dohme Novel compounds
JP2006502168A (ja) * 2002-09-06 2006-01-19 バーテックス　ファーマシューティカルズ　インコーポレイテッド イソオキサゾールおよびその使用
US20080153869A1 (en) 2004-06-14 2008-06-26 Bressi Jerome C Kinase Inhibitors
JP5015172B2 (ja) * 2005-12-23 2012-08-29 エフ．ホフマン−ラ ロシュ アーゲー アリール−イソオキサゾロ−４−イル−オキサジアゾール誘導体
CA2633536A1 (en) * 2005-12-27 2007-07-05 F. Hoffmann-La Roche Ag Aryl-isoxazol-4-yl-imidazo[1, 5-a]pyridine derivatives

Also Published As

Publication number Publication date
KR101121372B1 (ko) 2012-04-12
RU2008125039A (ru) 2010-02-10
ES2371935T3 (es) 2012-01-11
RU2425045C2 (ru) 2011-07-27
AU2006331437A1 (en) 2007-07-05
JP2009521516A (ja) 2009-06-04
IL192235A0 (en) 2009-02-11
TWI324998B (en) 2010-05-21
EP1968973A2 (en) 2008-09-17
CA2633367A1 (en) 2007-07-05
US7414061B2 (en) 2008-08-19
PT1968973E (pt) 2011-12-09
WO2007074078A3 (en) 2008-01-17
EP1968973B1 (en) 2011-10-05
ATE527255T1 (de) 2011-10-15
CN101351461A (zh) 2009-01-21
DK1968973T3 (da) 2011-10-31
AR058760A1 (es) 2008-02-20
BRPI0620773A2 (pt) 2011-11-22
AU2006331437B2 (en) 2012-07-05
CN101351461B (zh) 2011-09-07
PL1968973T3 (pl) 2012-03-30
US20070161654A1 (en) 2007-07-12
WO2007074078A2 (en) 2007-07-05
TW200736251A (en) 2007-10-01
KR20080080229A (ko) 2008-09-02
NO20082747L (no) 2008-09-22

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