ZA200705898B - Phenyl methanone derivatives and their use as glycine transporter 1 inhibitors - Google Patents
Phenyl methanone derivatives and their use as glycine transporter 1 inhibitorsInfo
- Publication number
- ZA200705898B ZA200705898B ZA200705898A ZA200705898A ZA200705898B ZA 200705898 B ZA200705898 B ZA 200705898B ZA 200705898 A ZA200705898 A ZA 200705898A ZA 200705898 A ZA200705898 A ZA 200705898A ZA 200705898 B ZA200705898 B ZA 200705898B
- Authority
- ZA
- South Africa
- Prior art keywords
- inhibitors
- glycine transporter
- phenyl methanone
- methanone derivatives
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05100473 | 2005-01-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200705898B true ZA200705898B (en) | 2009-07-29 |
Family
ID=36121826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200705898A ZA200705898B (en) | 2005-01-26 | 2007-07-18 | Phenyl methanone derivatives and their use as glycine transporter 1 inhibitors |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7442710B2 (fr) |
| EP (1) | EP1844045B1 (fr) |
| JP (1) | JP4829900B2 (fr) |
| KR (1) | KR100915472B1 (fr) |
| CN (1) | CN101146808B (fr) |
| AR (1) | AR052662A1 (fr) |
| AT (1) | ATE447572T1 (fr) |
| AU (1) | AU2006208547B2 (fr) |
| BR (1) | BRPI0607241A2 (fr) |
| CA (1) | CA2595605A1 (fr) |
| DE (1) | DE602006010175D1 (fr) |
| ES (1) | ES2332529T3 (fr) |
| IL (1) | IL184561A (fr) |
| MX (1) | MX2007008918A (fr) |
| NO (1) | NO20073717L (fr) |
| RU (1) | RU2007126951A (fr) |
| TW (1) | TW200637859A (fr) |
| WO (1) | WO2006079467A1 (fr) |
| ZA (1) | ZA200705898B (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR080375A1 (es) | 2010-03-05 | 2012-04-04 | Sanofi Aventis | Procedimiento para la preparacion de 2-(cicloheximetil)-n-{2-[(2s)-1-metilpirrolidin-2-il] etil}-1,2,3,4-tetrahidroisoquinolina- 7-sulfonamida |
| US9045459B2 (en) * | 2010-08-13 | 2015-06-02 | AbbVie Deutschland GmbH & Co. KG | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| WO2016029454A1 (fr) * | 2014-08-29 | 2016-03-03 | Merck Sharp & Dohme Corp. | Dérivés de tétrahydronaphtyridine comme modulateurs allostériques négatifs de mglur2, compositions et leur utilisation |
| CN111393366B (zh) * | 2020-06-05 | 2020-09-01 | 北京华氏开元医药科技有限公司 | 四氢异喹啉类衍生物、制备方法、药物组合物及应用 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5017800B1 (fr) * | 1967-08-02 | 1975-06-24 | ||
| JPS5017998B1 (fr) * | 1970-06-02 | 1975-06-25 | ||
| JPS5017999B1 (fr) * | 1970-06-02 | 1975-06-25 | ||
| DE2423847A1 (de) * | 1973-05-28 | 1975-01-02 | Ciba Geigy Ag | Neue sulfamoylbenzoesaeureamide |
| DE2611705A1 (de) * | 1976-03-18 | 1977-09-22 | Josef Dipl Chem Dr Rer N Klosa | N-5-(nitrofurfuryliden-)-1-amino- hydantoin enthaltende kristalloesungsmittel |
| IT1176613B (it) | 1984-08-14 | 1987-08-18 | Ravizza Spa | Derivati piperazinici farmacologicamente attivi e processo per la loro preparazione |
| RU2124511C1 (ru) | 1993-05-14 | 1999-01-10 | Фармасьютикал Ко., Лтд | Производные пиперазина |
| US6001854A (en) * | 1996-05-31 | 1999-12-14 | Allelix Neuroscience Inc. | Pharmaceutical for treating of neurological and neuropsychiatric disorders |
| IL138228A0 (en) | 1998-03-06 | 2001-10-31 | Janssen Pharmaceutica Nv | Glycine transport inhibitors |
| HUP0101281A3 (en) | 1998-03-06 | 2001-11-28 | Janssen Pharmaceutica Nv | Diphenyl-piperidine butanamides as glycine transport inhibitors, process for producing them, use of them for producing medicaments and the pharmaceutical compositions containing them |
| AP2002002603A0 (en) * | 2000-01-24 | 2002-09-30 | Warner Lambert Co | 3-aminoquinazolin-2,4-dione antibacterial agents. |
| CA2406652A1 (fr) | 2000-04-20 | 2001-11-01 | Nps Allelix Corp. | Aminopiperidines |
| GB0021419D0 (en) | 2000-08-31 | 2000-10-18 | Oxford Glycosciences Uk Ltd | Compounds |
| AU2001290786A1 (en) * | 2000-09-14 | 2002-03-26 | Gliatech, Inc. | Nitrogen-containing compounds and their use as glycine transport inhibitors |
| AU2002344951A1 (en) | 2001-07-02 | 2003-01-21 | Boehringer Ingelheim International Gmbh | Substituted piperazine and diazepanes as histamine h3 receptor agonists |
| WO2003035602A1 (fr) | 2001-10-25 | 2003-05-01 | Sankyo Company, Limited | Modulateurs lipidiques |
| MXPA05003660A (es) * | 2002-10-21 | 2005-06-08 | Warner Lambert Co | Derivados de quinolina como antagonistas de crth2. |
| AU2003274053A1 (en) | 2002-10-22 | 2004-05-13 | Glaxo Group Limited | Aryloxyalkylamine derivates as h3 receptor ligands |
| EP1489071A1 (fr) * | 2003-06-18 | 2004-12-22 | 4Sc Ag | Dérivés de 3,4-dihydro-1H-isoquinoline N-substitués utilisés comme modulateurs de canaux de potassium |
| US20050070570A1 (en) * | 2003-06-18 | 2005-03-31 | 4Sc Ag | Novel potassium channels modulators |
| GB0314479D0 (en) * | 2003-06-20 | 2003-07-23 | Glaxo Group Ltd | Compounds |
| NZ544820A (en) * | 2003-08-11 | 2009-02-28 | Hoffmann La Roche | Piperazine with or-substituted phenyl group and their use as GlyT1 inhibitors |
| KR100774621B1 (ko) * | 2003-09-09 | 2007-11-14 | 에프. 호프만-라 로슈 아게 | 정신병 치료용의 글라이신 섭취 억제제로서의1-벤조일-피페라진 유도체 |
| CN1874777B (zh) * | 2003-09-09 | 2012-07-04 | 弗·哈夫曼-拉罗切有限公司 | 作为甘氨酸摄取抑制剂用于治疗精神病的1-(2-氨基-苯甲酰基)-哌嗪衍生物 |
| GB0329362D0 (en) | 2003-12-18 | 2004-01-21 | Glaxo Group Ltd | Compounds |
| EP1761497B1 (fr) * | 2004-01-09 | 2008-09-03 | Corcept Therapeutics, Inc. | Composes d'azadecaline utilises en tant que modulateurs du recepteur glucocorticoide |
| DE102004020908A1 (de) * | 2004-04-28 | 2005-11-17 | Grünenthal GmbH | Substituierte 5,6,7,8,-Tetrahydro-pyrido[4,3-d]pyrimidin-2-yl- und 5,6,7,8,-Tetrahydro-chinazolin-2-yl-Verbindungen |
| EP1745018A1 (fr) | 2004-04-29 | 2007-01-24 | Merck & Co., Inc. | Inhibiteurs de transporteur de glycine à base d'azétidine |
| US7297700B2 (en) * | 2005-03-24 | 2007-11-20 | Renovis, Inc. | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof |
-
2006
- 2006-01-17 RU RU2007126951/04A patent/RU2007126951A/ru not_active Application Discontinuation
- 2006-01-17 EP EP06706263A patent/EP1844045B1/fr not_active Not-in-force
- 2006-01-17 AT AT06706263T patent/ATE447572T1/de active
- 2006-01-17 WO PCT/EP2006/000361 patent/WO2006079467A1/fr not_active Ceased
- 2006-01-17 AU AU2006208547A patent/AU2006208547B2/en not_active Ceased
- 2006-01-17 KR KR1020077019354A patent/KR100915472B1/ko not_active Expired - Fee Related
- 2006-01-17 BR BRPI0607241-0A patent/BRPI0607241A2/pt not_active IP Right Cessation
- 2006-01-17 ES ES06706263T patent/ES2332529T3/es active Active
- 2006-01-17 CA CA002595605A patent/CA2595605A1/fr not_active Abandoned
- 2006-01-17 DE DE602006010175T patent/DE602006010175D1/de active Active
- 2006-01-17 JP JP2007552553A patent/JP4829900B2/ja not_active Expired - Fee Related
- 2006-01-17 MX MX2007008918A patent/MX2007008918A/es active IP Right Grant
- 2006-01-17 CN CN2006800097689A patent/CN101146808B/zh not_active Expired - Fee Related
- 2006-01-23 TW TW095102414A patent/TW200637859A/zh unknown
- 2006-01-24 US US11/338,266 patent/US7442710B2/en not_active Expired - Fee Related
- 2006-01-26 AR ARP060100286A patent/AR052662A1/es unknown
-
2007
- 2007-07-12 IL IL184561A patent/IL184561A/en not_active IP Right Cessation
- 2007-07-18 NO NO20073717A patent/NO20073717L/no not_active Application Discontinuation
- 2007-07-18 ZA ZA200705898A patent/ZA200705898B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20060167023A1 (en) | 2006-07-27 |
| DE602006010175D1 (de) | 2009-12-17 |
| MX2007008918A (es) | 2007-08-21 |
| CA2595605A1 (fr) | 2006-08-03 |
| EP1844045A1 (fr) | 2007-10-17 |
| AU2006208547B2 (en) | 2011-02-10 |
| ATE447572T1 (de) | 2009-11-15 |
| JP2008528526A (ja) | 2008-07-31 |
| BRPI0607241A2 (pt) | 2009-08-25 |
| IL184561A0 (en) | 2007-10-31 |
| KR100915472B1 (ko) | 2009-09-03 |
| AU2006208547A1 (en) | 2006-08-03 |
| TW200637859A (en) | 2006-11-01 |
| US7442710B2 (en) | 2008-10-28 |
| CN101146808B (zh) | 2011-10-12 |
| NO20073717L (no) | 2007-08-23 |
| CN101146808A (zh) | 2008-03-19 |
| EP1844045B1 (fr) | 2009-11-04 |
| ES2332529T3 (es) | 2010-02-08 |
| IL184561A (en) | 2011-03-31 |
| RU2007126951A (ru) | 2009-03-10 |
| JP4829900B2 (ja) | 2011-12-07 |
| WO2006079467A1 (fr) | 2006-08-03 |
| AR052662A1 (es) | 2007-03-28 |
| KR20070099030A (ko) | 2007-10-08 |
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