ZA200705898B - Phenyl methanone derivatives and their use as glycine transporter 1 inhibitors - Google Patents

Phenyl methanone derivatives and their use as glycine transporter 1 inhibitors

Info

Publication number: ZA200705898B
Authority: ZA; South Africa
Prior art keywords: inhibitors; glycine transporter; phenyl methanone; methanone derivatives; derivatives
Prior art date: 2005-01-26

Application number

ZA200705898A

Other languages

English (en)

Inventor

Jolidon Synese

Norcross Roger David

Narquizian Robert

Pinard Emmanuel

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-01-26

Filing date

2007-07-18

Publication date

2009-07-29

2007-07-18 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2009-07-29 Publication of ZA200705898B publication Critical patent/ZA200705898B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

ZA200705898A 2005-01-26 2007-07-18 Phenyl methanone derivatives and their use as glycine transporter 1 inhibitors ZA200705898B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP05100473		2005-01-26

Publications (1)

Publication Number	Publication Date
ZA200705898B true ZA200705898B (en)	2009-07-29

Family

ID=36121826

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200705898A ZA200705898B (en)	2005-01-26	2007-07-18	Phenyl methanone derivatives and their use as glycine transporter 1 inhibitors

Country Status (19)

Country	Link
US (1)	US7442710B2 (xx)
EP (1)	EP1844045B1 (xx)
JP (1)	JP4829900B2 (xx)
KR (1)	KR100915472B1 (xx)
CN (1)	CN101146808B (xx)
AR (1)	AR052662A1 (xx)
AT (1)	ATE447572T1 (xx)
AU (1)	AU2006208547B2 (xx)
BR (1)	BRPI0607241A2 (xx)
CA (1)	CA2595605A1 (xx)
DE (1)	DE602006010175D1 (xx)
ES (1)	ES2332529T3 (xx)
IL (1)	IL184561A (xx)
MX (1)	MX2007008918A (xx)
NO (1)	NO20073717L (xx)
RU (1)	RU2007126951A (xx)
TW (1)	TW200637859A (xx)
WO (1)	WO2006079467A1 (xx)
ZA (1)	ZA200705898B (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR080375A1 (es)	2010-03-05	2012-04-04	Sanofi Aventis	Procedimiento para la preparacion de 2-(cicloheximetil)-n-{2-[(2s)-1-metilpirrolidin-2-il] etil}-1,2,3,4-tetrahidroisoquinolina- 7-sulfonamida
US9045459B2 (en) *	2010-08-13	2015-06-02	AbbVie Deutschland GmbH & Co. KG	Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
WO2016029454A1 (en) *	2014-08-29	2016-03-03	Merck Sharp & Dohme Corp.	TETRAHYDRONAPHTHYRIDINE DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE
CN111393366B (zh) *	2020-06-05	2020-09-01	北京华氏开元医药科技有限公司	四氢异喹啉类衍生物、制备方法、药物组合物及应用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5017800B1 (xx) *	1967-08-02	1975-06-24
JPS5017998B1 (xx) *	1970-06-02	1975-06-25
JPS5017999B1 (xx) *	1970-06-02	1975-06-25
DE2423847A1 (de) *	1973-05-28	1975-01-02	Ciba Geigy Ag	Neue sulfamoylbenzoesaeureamide
DE2611705A1 (de) *	1976-03-18	1977-09-22	Josef Dipl Chem Dr Rer N Klosa	N-5-(nitrofurfuryliden-)-1-amino- hydantoin enthaltende kristalloesungsmittel
IT1176613B (it)	1984-08-14	1987-08-18	Ravizza Spa	Derivati piperazinici farmacologicamente attivi e processo per la loro preparazione
RU2124511C1 (ru)	1993-05-14	1999-01-10	Фармасьютикал Ко., Лтд	Производные пиперазина
US6001854A (en) *	1996-05-31	1999-12-14	Allelix Neuroscience Inc.	Pharmaceutical for treating of neurological and neuropsychiatric disorders
SK13092000A3 (sk)	1998-03-06	2001-03-12	Janssen Pharmaceutica N. V.	Inhibítory prenosu glycínu, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a ich použitie
WO1999044596A2 (en)	1998-03-06	1999-09-10	Janssen Pharmaceutica N.V.	Glycine transport inhibitors
CN1425008A (zh) *	2000-01-24	2003-06-18	沃尼尔·朗伯公司	3－氨基喹唑啉－2,4－二酮抗菌剂
AU2001254546A1 (en)	2000-04-20	2001-11-07	Nps Allelix Corp.	Aminopiperidines
GB0021419D0 (en)	2000-08-31	2000-10-18	Oxford Glycosciences Uk Ltd	Compounds
US6946474B2 (en) *	2000-09-14	2005-09-20	Merck & Co., Inc.	Nitrogen-containing compounds and their use as glycine transport inhibitors
WO2003004480A2 (en)	2001-07-02	2003-01-16	Novo Nordisk A/S	Substituted piperazine and diazepanes as histamine h3 receptor agonists
WO2003035602A1 (en)	2001-10-25	2003-05-01	Sankyo Company, Limited	Lipid modulators
WO2004035543A1 (en) *	2002-10-21	2004-04-29	Warner-Lambert Company Llc	Tetrahydroquinoline derivatives as crth2 antagonists
AU2003274053A1 (en)	2002-10-22	2004-05-13	Glaxo Group Limited	Aryloxyalkylamine derivates as h3 receptor ligands
EP1489071A1 (en) *	2003-06-18	2004-12-22	4Sc Ag	N-substituted, 3,4-dihydro-1H-isoquinoline as potassium channels modulators
US20050070570A1 (en) *	2003-06-18	2005-03-31	4Sc Ag	Novel potassium channels modulators
GB0314479D0 (en) *	2003-06-20	2003-07-23	Glaxo Group Ltd	Compounds
RS53252B (sr) *	2003-08-11	2014-08-29	F.Hoffmann-La Roche Ag.	Piperazin sa or-supstituisanom fenil grupom i njihova upotreba kao inhibitora glyt1
DK1703909T3 (da) *	2003-09-09	2009-06-22	Hoffmann La Roche	1-benzoyl-piperazinderivater som glycinoptagelsesinhibitorer til behandling af psykoser
WO2005023260A1 (en) *	2003-09-09	2005-03-17	F. Hoffmann-La Roche Ag	1- (2-amino-benzol) -piperazine derivatives as glycine uptake inhibitors for the treatment of psychoses
GB0329362D0 (en)	2003-12-18	2004-01-21	Glaxo Group Ltd	Compounds
WO2005070893A2 (en) *	2004-01-09	2005-08-04	Corcept Therapeutics, Inc.	Azadecalin glucocorticoid receptor modulators
DE102004020908A1 (de) *	2004-04-28	2005-11-17	Grünenthal GmbH	Substituierte 5,6,7,8,-Tetrahydro-pyrido[4,3-d]pyrimidin-2-yl- und 5,6,7,8,-Tetrahydro-chinazolin-2-yl-Verbindungen
EP1745018A1 (en)	2004-04-29	2007-01-24	Merck & Co., Inc.	Azetidine glycine transporter inhibitors
US7297700B2 (en) *	2005-03-24	2007-11-20	Renovis, Inc.	Bicycloheteroaryl compounds as P2X7 modulators and uses thereof

2006
- 2006-01-17 AT AT06706263T patent/ATE447572T1/de active
- 2006-01-17 DE DE602006010175T patent/DE602006010175D1/de active Active
- 2006-01-17 AU AU2006208547A patent/AU2006208547B2/en not_active Ceased
- 2006-01-17 KR KR1020077019354A patent/KR100915472B1/ko not_active Expired - Fee Related
- 2006-01-17 ES ES06706263T patent/ES2332529T3/es active Active
- 2006-01-17 MX MX2007008918A patent/MX2007008918A/es active IP Right Grant
- 2006-01-17 CN CN2006800097689A patent/CN101146808B/zh not_active Expired - Fee Related
- 2006-01-17 JP JP2007552553A patent/JP4829900B2/ja not_active Expired - Fee Related
- 2006-01-17 EP EP06706263A patent/EP1844045B1/en not_active Not-in-force
- 2006-01-17 RU RU2007126951/04A patent/RU2007126951A/ru not_active Application Discontinuation
- 2006-01-17 BR BRPI0607241-0A patent/BRPI0607241A2/pt not_active IP Right Cessation
- 2006-01-17 CA CA002595605A patent/CA2595605A1/en not_active Abandoned
- 2006-01-17 WO PCT/EP2006/000361 patent/WO2006079467A1/en not_active Ceased
- 2006-01-23 TW TW095102414A patent/TW200637859A/zh unknown
- 2006-01-24 US US11/338,266 patent/US7442710B2/en not_active Expired - Fee Related
- 2006-01-26 AR ARP060100286A patent/AR052662A1/es unknown
2007
- 2007-07-12 IL IL184561A patent/IL184561A/en not_active IP Right Cessation
- 2007-07-18 NO NO20073717A patent/NO20073717L/no not_active Application Discontinuation
- 2007-07-18 ZA ZA200705898A patent/ZA200705898B/xx unknown

Also Published As

Publication number	Publication date
EP1844045A1 (en)	2007-10-17
AU2006208547B2 (en)	2011-02-10
JP2008528526A (ja)	2008-07-31
DE602006010175D1 (de)	2009-12-17
CA2595605A1 (en)	2006-08-03
AR052662A1 (es)	2007-03-28
NO20073717L (no)	2007-08-23
KR20070099030A (ko)	2007-10-08
MX2007008918A (es)	2007-08-21
BRPI0607241A2 (pt)	2009-08-25
ATE447572T1 (de)	2009-11-15
CN101146808A (zh)	2008-03-19
KR100915472B1 (ko)	2009-09-03
US20060167023A1 (en)	2006-07-27
TW200637859A (en)	2006-11-01
IL184561A (en)	2011-03-31
EP1844045B1 (en)	2009-11-04
CN101146808B (zh)	2011-10-12
WO2006079467A1 (en)	2006-08-03
US7442710B2 (en)	2008-10-28
RU2007126951A (ru)	2009-03-10
ES2332529T3 (es)	2010-02-08
AU2006208547A1 (en)	2006-08-03
JP4829900B2 (ja)	2011-12-07
IL184561A0 (en)	2007-10-31

Publication	Publication Date	Title
ZA200705834B (en)	2008-09-25	Heterocyclic substituted phenyl methanones as inhibitors of the glycine transporter 1
PL1891066T3 (pl)	2011-05-31	Związki i kompozycje jako inhibitory kinazy białkowej
EP1841431A4 (en)	2009-12-09	COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS
IL179613A0 (en)	2007-05-15	Compounds and compositions as protein kinase inhibitors
PL1713806T3 (pl)	2013-09-30	Związki i kompozycje jako inhibitory kinaz białkowych
IL182687A0 (en)	2007-09-20	Compounds and compositions as protein kinase inhibitors
IL192053A0 (en)	2008-12-29	2-adamantylurea derivatives as selective 11??-hsd1 inhibitors
IL194404A0 (en)	2009-08-03	Benzyl phenyl glucopyranoside derivatives and pharmaceutical compositions containing the same
IL185199A0 (en)	2008-01-06	Indole compound and use thereof
ZA200702394B (en)	2008-11-26	Indozolone derivatives as 11b-HSD1 inhibitors
AP2007004198A0 (en)	2007-10-31	Bicyclic [3.1.0] heteroaryl amides as type I glycine transport inhibitors
IL187620A0 (en)	2008-03-20	17??-hsd1 and sts inhibitors
ZA200700181B (en)	2009-03-25	Aryl-pyridine derivatives as 11-beta-HSD1 inhibitors
IL225653A0 (en)	2013-06-27	Homo- and hetero-cyclic compounds suitable as cetp inhibitors
GB0512940D0 (en)	2005-08-03	Compounds and their use
ZA200706672B (en)	2008-10-29	2,4-Diamino-pyridopyrimidine derivatives and their use as mTOR inhibitors
EP1942108A4 (en)	2010-10-20	BASIC GROUP-CONTAINING COMPOUND AND USE THEREOF
EP1765820A4 (en)	2010-07-21	COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF PROTEIN KINASES
ZA200703130B (en)	2008-07-30	Compounds and compositions as protein kinase inhibitors
GB0520743D0 (en)	2005-11-23	Compounds and their use
ZA200705898B (en)	2009-07-29	Phenyl methanone derivatives and their use as glycine transporter 1 inhibitors
AP1963A (en)	2009-03-03	Substituted pyrrole derivatives and their use as HMG-co inhibitors
EP1840121A4 (en)	2011-05-11	GLYCINE DERIVATIVES AND THEIR USE
EP2068903A4 (en)	2010-11-03	S-NITROSOTHIOL COMPOUNDS AND RELATED DERIVATIVES
ZA200810629B (en)	2010-02-24	Phenylpentadienoyl derivatives and their use as par 1 antagonists