ZA200600693B - Combination of mGluR2 antagonist and AChE inhibitor for treatment of acute and/or chronic neurological disorders - Google Patents

Combination of mGluR2 antagonist and AChE inhibitor for treatment of acute and/or chronic neurological disorders Download PDF

Info

Publication number: ZA200600693B
Authority: ZA; South Africa
Prior art keywords: benzo; dihydro; diazepin; phenyl; pyridin
Prior art date: 2003-07-25

Application number

ZA200600693A

Other languages

English (en)

Inventor

Ballard Theresa Maria

Goetschi Erwin

Woltering Thomas Johannes

Gatti Mcarthur Silvia

Wichmann Juergen

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-25

Filing date

2006-01-24

Publication date

2007-05-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34130033&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200600693(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-01-24 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2007-05-30 Publication of ZA200600693B publication Critical patent/ZA200600693B/en

Links

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LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
230000009466 transformation Effects 0.000 description 1
238000000844 transformation Methods 0.000 description 1
230000009529 traumatic brain injury Effects 0.000 description 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
229930195735 unsaturated hydrocarbon Natural products 0.000 description 1
230000008673 vomiting Effects 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
239000008096 xylene Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Psychology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)

ZA200600693A 2003-07-25 2006-01-24 Combination of mGluR2 antagonist and AChE inhibitor for treatment of acute and/or chronic neurological disorders ZA200600693B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP03016968		2003-07-25

Publications (1)

Publication Number	Publication Date
ZA200600693B true ZA200600693B (en)	2007-05-30

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ID=34130033

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Application Number	Title	Priority Date	Filing Date
ZA200600693A ZA200600693B (en)	2003-07-25	2006-01-24	Combination of mGluR2 antagonist and AChE inhibitor for treatment of acute and/or chronic neurological disorders

Country Status (27)

Country	Link
US (1)	US7235547B2 (ko)
EP (1)	EP1651234B1 (ko)
JP (1)	JP5005343B2 (ko)
KR (1)	KR100764330B1 (ko)
CN (1)	CN1856312A (ko)
AR (1)	AR045926A1 (ko)
AT (1)	ATE374030T1 (ko)
AU (1)	AU2004262897B9 (ko)
BR (1)	BRPI0412919A (ko)
CA (1)	CA2532347C (ko)
CO (1)	CO5640124A2 (ko)
DE (1)	DE602004009195T2 (ko)
DK (1)	DK1651234T3 (ko)
ES (1)	ES2293287T3 (ko)
HR (1)	HRP20070552T3 (ko)
IL (1)	IL173131A (ko)
MX (1)	MXPA06000705A (ko)
MY (1)	MY138394A (ko)
NO (1)	NO20060328L (ko)
NZ (1)	NZ544719A (ko)
PL (1)	PL1651234T3 (ko)
PT (1)	PT1651234E (ko)
RU (1)	RU2357734C2 (ko)
SI (1)	SI1651234T1 (ko)
TW (1)	TW200524614A (ko)
WO (1)	WO2005014002A1 (ko)
ZA (1)	ZA200600693B (ko)

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US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
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RU2472475C2 (ru) *	2010-04-20	2013-01-20	Учреждение образования "Белорусский государственный медицинский университет" (УО БГМУ)	Способ комбинированного лечения глаукомной оптической нейропатии
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2004
- 2004-07-17 CN CNA2004800278083A patent/CN1856312A/zh active Pending
- 2004-07-17 RU RU2006105721/15A patent/RU2357734C2/ru not_active IP Right Cessation
- 2004-07-17 NZ NZ544719A patent/NZ544719A/xx unknown
- 2004-07-17 HR HR20070552T patent/HRP20070552T3/xx unknown
- 2004-07-17 KR KR1020067001762A patent/KR100764330B1/ko not_active Expired - Fee Related
- 2004-07-17 CA CA2532347A patent/CA2532347C/en not_active Expired - Fee Related
- 2004-07-17 WO PCT/EP2004/008020 patent/WO2005014002A1/en not_active Ceased
- 2004-07-17 AU AU2004262897A patent/AU2004262897B9/en not_active Ceased
- 2004-07-17 PL PL04741126T patent/PL1651234T3/pl unknown
- 2004-07-17 DE DE602004009195T patent/DE602004009195T2/de not_active Expired - Lifetime
- 2004-07-17 AT AT04741126T patent/ATE374030T1/de active
- 2004-07-17 JP JP2006521458A patent/JP5005343B2/ja not_active Expired - Fee Related
- 2004-07-17 MX MXPA06000705A patent/MXPA06000705A/es active IP Right Grant
- 2004-07-17 SI SI200430524T patent/SI1651234T1/sl unknown
- 2004-07-17 BR BRPI0412919-9A patent/BRPI0412919A/pt not_active Application Discontinuation
- 2004-07-17 EP EP04741126A patent/EP1651234B1/en not_active Expired - Lifetime
- 2004-07-17 PT PT04741126T patent/PT1651234E/pt unknown
- 2004-07-17 ES ES04741126T patent/ES2293287T3/es not_active Expired - Lifetime
- 2004-07-17 DK DK04741126T patent/DK1651234T3/da active
- 2004-07-21 TW TW093121764A patent/TW200524614A/zh unknown
- 2004-07-22 US US10/896,494 patent/US7235547B2/en not_active Expired - Fee Related
- 2004-07-22 AR ARP040102592A patent/AR045926A1/es not_active Application Discontinuation
- 2004-07-23 MY MYPI20042981A patent/MY138394A/en unknown
2006
- 2006-01-12 IL IL173131A patent/IL173131A/en not_active IP Right Cessation
- 2006-01-20 NO NO20060328A patent/NO20060328L/no not_active Application Discontinuation
- 2006-01-24 CO CO06006378A patent/CO5640124A2/es not_active Application Discontinuation
- 2006-01-24 ZA ZA200600693A patent/ZA200600693B/en unknown

Also Published As

Publication number	Publication date
NZ544719A (en)	2009-04-30
AU2004262897B2 (en)	2009-08-20
HRP20070552T3 (en)	2008-05-31
WO2005014002A1 (en)	2005-02-17
CA2532347C (en)	2012-03-27
AU2004262897A1 (en)	2005-02-17
RU2357734C2 (ru)	2009-06-10
ATE374030T1 (de)	2007-10-15
BRPI0412919A (pt)	2006-09-26
RU2006105721A (ru)	2007-09-10
CA2532347A1 (en)	2005-02-17
KR100764330B1 (ko)	2007-10-05
CO5640124A2 (es)	2006-05-31
CN1856312A (zh)	2006-11-01
DE602004009195T2 (de)	2008-06-26
IL173131A0 (en)	2006-06-11
PT1651234E (pt)	2007-12-28
DE602004009195D1 (de)	2007-11-08
NO20060328L (no)	2006-02-17
MY138394A (en)	2009-05-29
EP1651234A1 (en)	2006-05-03
EP1651234B1 (en)	2007-09-26
AR045926A1 (es)	2005-11-16
JP2007504096A (ja)	2007-03-01
MXPA06000705A (es)	2006-04-11
PL1651234T3 (pl)	2008-02-29
US7235547B2 (en)	2007-06-26
JP5005343B2 (ja)	2012-08-22
ES2293287T3 (es)	2008-03-16
SI1651234T1 (sl)	2008-02-29
AU2004262897B9 (en)	2009-12-17
US20050049243A1 (en)	2005-03-03
IL173131A (en)	2010-12-30
KR20060037404A (ko)	2006-05-03
DK1651234T3 (da)	2008-01-28
TW200524614A (en)	2005-08-01

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