ZA200607913B - Isoquinoline Derivatives and methods of use thereof - Google Patents
Isoquinoline Derivatives and methods of use thereofInfo
- Publication number
- ZA200607913B ZA200607913B ZA200607913A ZA200607913A ZA200607913B ZA 200607913 B ZA200607913 B ZA 200607913B ZA 200607913 A ZA200607913 A ZA 200607913A ZA 200607913 A ZA200607913 A ZA 200607913A ZA 200607913 B ZA200607913 B ZA 200607913B
- Authority
- ZA
- South Africa
- Prior art keywords
- methods
- isoquinoline derivatives
- isoquinoline
- derivatives
- Prior art date
Links
- 125000002183 isoquinolinyl group Chemical class C1(=NC=CC2=CC=CC=C12)* 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
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- C07D221/18—Ring systems of four or more rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54789904P | 2004-02-26 | 2004-02-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200607913B true ZA200607913B (en) | 2008-02-27 |
Family
ID=34910959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200607913A ZA200607913B (en) | 2004-02-26 | 2006-09-21 | Isoquinoline Derivatives and methods of use thereof |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20050228007A1 (xx) |
| EP (2) | EP2033645A1 (xx) |
| JP (1) | JP2007527872A (xx) |
| KR (1) | KR20060125909A (xx) |
| CN (1) | CN1964716A (xx) |
| AU (1) | AU2005216978A1 (xx) |
| BR (1) | BRPI0508233A (xx) |
| CA (1) | CA2557547A1 (xx) |
| EA (1) | EA200601558A1 (xx) |
| IL (1) | IL177650A0 (xx) |
| MX (1) | MXPA06009701A (xx) |
| NO (1) | NO20064328L (xx) |
| WO (1) | WO2005082368A1 (xx) |
| ZA (1) | ZA200607913B (xx) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030096833A1 (en) * | 2001-08-31 | 2003-05-22 | Jagtap Prakash G. | Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof |
| US6956035B2 (en) * | 2001-08-31 | 2005-10-18 | Inotek Pharmaceuticals Corporation | Isoquinoline derivatives and methods of use thereof |
| EP1603567A4 (en) * | 2003-02-28 | 2006-10-18 | Inotek Pharmaceuticals Corp | TETRACYCLIC BENZAMIDE DERIVATIVES AND METHOD OF USE THEREOF |
| CN101014343A (zh) * | 2004-02-26 | 2007-08-08 | 伊诺泰克制药公司 | 四环内酰胺衍生物及其应用 |
| WO2006009718A2 (en) * | 2004-06-16 | 2006-01-26 | Inotek Pharmaceuticals Corporation | Methods for treating or preventing erectile dysfunction or urinary incontinence |
| US20060287311A1 (en) * | 2005-02-25 | 2006-12-21 | Inotek Pharmaceuticals Corporation | Tetracyclic Sulfonamide Compounds and methods of use thereof |
| AU2006219022A1 (en) * | 2005-02-25 | 2006-09-08 | Inotek Pharmaceuticals Corporation | Isoqunoline Compounds and methods of use thereof |
| CA2598647A1 (en) * | 2005-02-25 | 2006-09-08 | Inotek Pharmaceuticals Corporation | Tetracyclic amino and carboxamido compounds and methods of use thereof |
| CN101316592A (zh) * | 2005-08-24 | 2008-12-03 | 伊诺泰克制药公司 | 茚并异喹啉酮类似物及其用法 |
| AU2007266840B2 (en) | 2006-05-31 | 2012-09-20 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Pyrrolo[1,2-A]pyrazin-1(2H)-one and pyrrolo[1,2-D][1,2,4]triazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose)polymerase(PARP) |
| MX2009007200A (es) | 2007-01-10 | 2009-07-15 | Angeletti P Ist Richerche Bio | Indazoles sustituidos con amida como inhibidores de poli(adp-ribosa)polimerasa (parp). |
| KR20090115879A (ko) * | 2007-02-28 | 2009-11-09 | 이노텍 파마슈티컬스 코포레이션 | 인데노이소퀴놀리논 유사체와 이의 이용 방법 |
| GB0716532D0 (en) | 2007-08-24 | 2007-10-03 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| ES2524787T3 (es) | 2007-11-15 | 2014-12-12 | Msd Italia S.R.L. | Derivados de piridazinona como inhibidores de PARP |
| GB0804755D0 (en) | 2008-03-14 | 2008-04-16 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| AU2009322342A1 (en) | 2008-12-05 | 2011-06-30 | Merck Sharp & Dohme Corp. | Morpholinone compounds as factor IXa inhibitors |
| KR20150009599A (ko) * | 2012-06-20 | 2015-01-26 | 에프. 호프만-라 로슈 아게 | 탄키라아제의 피라노피리돈 억제제 |
| KR102237639B1 (ko) | 2012-10-11 | 2021-04-07 | 다이이찌 산쿄 가부시키가이샤 | 항체-약물 콘주게이트 |
| ES2782248T3 (es) | 2012-10-19 | 2020-09-11 | Daiichi Sankyo Co Ltd | Conjugado de anticuerpo y fármaco producido por la unión a través de un enlazador que tiene estructura hidrófila |
| US11173213B2 (en) | 2015-06-29 | 2021-11-16 | Daiichi Sankyo Company, Limited | Method for selectively manufacturing antibody-drug conjugate |
| CN110049779A (zh) | 2016-12-12 | 2019-07-23 | 第一三共株式会社 | 抗体-药物缀合物和免疫检查点抑制剂的组合 |
| EP3572428A4 (en) | 2017-01-17 | 2020-12-30 | Daiichi Sankyo Company, Limited | ANTI-BODY ANTI-GPR20 AND ANTI-BODY-DRUG CONJUGATE ANTI-GPR20 |
| TW202530271A (zh) | 2017-05-15 | 2025-08-01 | 日商第一三共股份有限公司 | 抗體-藥物結合物及其用途 |
| PE20251254A1 (es) | 2017-05-24 | 2025-05-06 | Novartis Ag | Proteinas de anticuerpo injertadas con citocina y metodos de uso en el tratamiento del cancer |
| KR20250084239A (ko) | 2017-08-31 | 2025-06-10 | 다이이찌 산쿄 가부시키가이샤 | 항체-약물 콘주게이트의 개량 제조 방법 |
| CA3074208C (en) | 2017-08-31 | 2023-10-03 | Daiichi Sankyo Company, Limited | Novel method for producing antibody-drug conjugate |
| US12479926B2 (en) | 2018-05-18 | 2025-11-25 | Daiichi Sankyo Co., Ltd. | Anti-MUC1 antibody-drug conjugate |
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| CN113480520B (zh) * | 2021-08-16 | 2022-05-13 | 吉林大学 | 一种异喹啉-1,3(2h,4h)-二酮衍生物及其应用 |
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2005
- 2005-02-25 MX MXPA06009701A patent/MXPA06009701A/es not_active Application Discontinuation
- 2005-02-25 CA CA002557547A patent/CA2557547A1/en not_active Abandoned
- 2005-02-25 CN CNA2005800131929A patent/CN1964716A/zh active Pending
- 2005-02-25 EP EP08015611A patent/EP2033645A1/en not_active Withdrawn
- 2005-02-25 AU AU2005216978A patent/AU2005216978A1/en not_active Abandoned
- 2005-02-25 US US11/066,824 patent/US20050228007A1/en not_active Abandoned
- 2005-02-25 JP JP2007501043A patent/JP2007527872A/ja not_active Withdrawn
- 2005-02-25 EA EA200601558A patent/EA200601558A1/ru unknown
- 2005-02-25 KR KR1020067019577A patent/KR20060125909A/ko not_active Withdrawn
- 2005-02-25 EP EP05723909A patent/EP1722797A4/en not_active Withdrawn
- 2005-02-25 WO PCT/US2005/006243 patent/WO2005082368A1/en not_active Ceased
- 2005-02-25 BR BRPI0508233-1A patent/BRPI0508233A/pt not_active IP Right Cessation
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2006
- 2006-08-22 IL IL177650A patent/IL177650A0/en unknown
- 2006-09-21 ZA ZA200607913A patent/ZA200607913B/xx unknown
- 2006-09-25 NO NO20064328A patent/NO20064328L/no not_active Application Discontinuation
Also Published As
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| KR20060125909A (ko) | 2006-12-06 |
| NO20064328L (no) | 2006-10-26 |
| WO2005082368A1 (en) | 2005-09-09 |
| US20050228007A1 (en) | 2005-10-13 |
| EP1722797A1 (en) | 2006-11-22 |
| EP2033645A1 (en) | 2009-03-11 |
| IL177650A0 (en) | 2006-12-31 |
| EP1722797A4 (en) | 2008-03-19 |
| MXPA06009701A (es) | 2007-03-26 |
| CA2557547A1 (en) | 2005-09-09 |
| BRPI0508233A (pt) | 2007-07-17 |
| JP2007527872A (ja) | 2007-10-04 |
| AU2005216978A1 (en) | 2005-09-09 |
| EA200601558A1 (ru) | 2007-08-31 |
| CN1964716A (zh) | 2007-05-16 |
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