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AU9298198A - Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity - Google Patents

Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity

Info

Publication number
AU9298198A
AU9298198A AU92981/98A AU9298198A AU9298198A AU 9298198 A AU9298198 A AU 9298198A AU 92981/98 A AU92981/98 A AU 92981/98A AU 9298198 A AU9298198 A AU 9298198A AU 9298198 A AU9298198 A AU 9298198A
Authority
AU
Australia
Prior art keywords
compositions
methods
heterocyclic compounds
parp activity
inhibiting parp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU92981/98A
Inventor
Paul F. Jackson
Keith M. Maclin
Jie Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Corp of North America
Original Assignee
Guilford Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/145,185 external-priority patent/US6121278A/en
Application filed by Guilford Pharmaceuticals Inc filed Critical Guilford Pharmaceuticals Inc
Publication of AU9298198A publication Critical patent/AU9298198A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU92981/98A 1997-09-03 1998-09-02 Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity Abandoned AU9298198A (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US92252097A 1997-09-03 1997-09-03
US08922520 1997-09-03
US7951198A 1998-05-15 1998-05-15
US09079511 1998-05-15
US09145185 1998-09-01
US09/145,185 US6121278A (en) 1997-09-03 1998-09-01 Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity
PCT/US1998/018188 WO1999011644A1 (en) 1997-09-03 1998-09-02 Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity

Publications (1)

Publication Number Publication Date
AU9298198A true AU9298198A (en) 1999-03-22

Family

ID=27373496

Family Applications (1)

Application Number Title Priority Date Filing Date
AU92981/98A Abandoned AU9298198A (en) 1997-09-03 1998-09-02 Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity

Country Status (2)

Country Link
AU (1) AU9298198A (en)
WO (1) WO1999011644A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6235748B1 (en) 1997-09-03 2001-05-22 Guilford Pharmaceuticals Inc. Oxo-substituted compounds, process of making, and compositions and methods for inhibiting parp activity
US6291425B1 (en) 1999-09-01 2001-09-18 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage
EP1077944A1 (en) * 1998-05-15 2001-02-28 Guilford Pharmaceuticals Inc. Carboxamide compounds, compositions, and methods for inhibiting parp activity
US20030078212A1 (en) * 1998-10-30 2003-04-24 Jia-He Li Pharmaceutical compositions containing poly(adp-ribose) glycohydrolase inhibitors and methods of using the same
ES2218110T3 (en) 1999-01-11 2004-11-16 Agouron Pharmaceuticals, Inc. TRICYCLE POLY INHIBITORS (ADP-RIBOSA) POLYMERASES.
JP2001002572A (en) * 1999-04-19 2001-01-09 Sankyo Co Ltd Neurotrophin action enhancer
ECSP003637A (en) 1999-08-31 2002-03-25 Agouron Pharma TRICYCLE POLY INHIBITORS (ADP-RIBOSA) POLYMERASES
IL143349A0 (en) * 1999-09-28 2002-04-21 Basf Ag Azepinoindole derivatives, the production and use thereof
US6531464B1 (en) 1999-12-07 2003-03-11 Inotek Pharmaceutical Corporation Methods for the treatment of neurodegenerative disorders using substituted phenanthridinone derivatives
US6476048B1 (en) 1999-12-07 2002-11-05 Inotek Pharamaceuticals Corporation Substituted phenanthridinones and methods of use thereof
US6534651B2 (en) 2000-04-06 2003-03-18 Inotek Pharmaceuticals Corp. 7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof
US7122679B2 (en) 2000-05-09 2006-10-17 Cephalon, Inc. Multicyclic compounds and the use thereof
US6956035B2 (en) 2001-08-31 2005-10-18 Inotek Pharmaceuticals Corporation Isoquinoline derivatives and methods of use thereof
US20030096833A1 (en) 2001-08-31 2003-05-22 Jagtap Prakash G. Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof
US7217709B2 (en) 2003-02-28 2007-05-15 Inotek Pharmaceuticals Corporation Tetracyclic benzamide derivatives and methods of use thereof
EP2033645A1 (en) 2004-02-26 2009-03-11 Inotek Pharmaceuticals Corporation Isoquinoline derivatives and methods of use thereof
WO2006078711A2 (en) 2005-01-19 2006-07-27 Mgi Gp, Inc. Diazabenzo[de]anthracen-3-one compounds and methods for inhibiting parp
EP1855676A4 (en) 2005-02-25 2008-05-21 Inotek Pharmaceuticals Corp TETRACYCLIC AMINO AND CARBOXAMIDO COMPOUNDS AND METHODS OF USE THEREOF
KR20080039508A (en) 2005-08-24 2008-05-07 이노텍 파마슈티컬스 코포레이션 Indenoisoquinolinone analogs and methods of using the same
CA2629376C (en) 2005-11-14 2015-06-09 Centre National De La Recherche Scientifique - Cnrs Inhibitors of parp activity and uses thereof
RU2009135818A (en) 2007-02-28 2011-04-10 Инотек Фармасьютикалз Корпорейшн (Us) INDENOISOCHINOLINONE ANALOGUES AND WAYS OF THEIR APPLICATION
PL2209375T3 (en) 2007-10-03 2014-12-31 Eisai Inc Parp inhibitor compounds, compositions and methods of use
US8999985B2 (en) 2010-12-02 2015-04-07 Shanghai De Novo Pharmatech Co Ltd. Substituted phthalazin-1(2H)-ones, preparation processes and medical uses thereof
TW201702218A (en) 2014-12-12 2017-01-16 美國杰克森實驗室 Compositions and methods relating to the treatment of cancer, autoimmune disease, and neurodegenerative disease
JP6871169B2 (en) 2015-03-02 2021-05-12 シナイ ヘルス システム Homologous recombination factor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9404485D0 (en) * 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
US5589483A (en) * 1994-12-21 1996-12-31 Geron Corporation Isoquinoline poly (ADP-ribose) polymerase inhibitors to treat skin diseases associated with cellular senescence

Also Published As

Publication number Publication date
WO1999011644A1 (en) 1999-03-11

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase