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AU1208999A - Compounds which inhibit tryptase activity - Google Patents

Compounds which inhibit tryptase activity

Info

Publication number
AU1208999A
AU1208999A AU12089/99A AU1208999A AU1208999A AU 1208999 A AU1208999 A AU 1208999A AU 12089/99 A AU12089/99 A AU 12089/99A AU 1208999 A AU1208999 A AU 1208999A AU 1208999 A AU1208999 A AU 1208999A
Authority
AU
Australia
Prior art keywords
compounds
tryptase activity
inhibit tryptase
inhibit
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU12089/99A
Inventor
Laurence Burgess
James P. Rizzi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Array Biopharma Inc
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of AU1208999A publication Critical patent/AU1208999A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/08—Hydrogen atoms or radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU12089/99A 1997-11-10 1998-11-03 Compounds which inhibit tryptase activity Abandoned AU1208999A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6515497P 1997-11-10 1997-11-10
US60065154 1997-11-10
US17969598A 1998-10-27 1998-10-27
US09179695 1998-10-27
PCT/US1998/023362 WO1999024407A1 (en) 1997-11-10 1998-11-03 Compounds which inhibit tryptase activity

Publications (1)

Publication Number Publication Date
AU1208999A true AU1208999A (en) 1999-05-31

Family

ID=26745272

Family Applications (1)

Application Number Title Priority Date Filing Date
AU12089/99A Abandoned AU1208999A (en) 1997-11-10 1998-11-03 Compounds which inhibit tryptase activity

Country Status (3)

Country Link
EP (1) EP1030844A1 (en)
AU (1) AU1208999A (en)
WO (1) WO1999024407A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3421349B2 (en) 1996-02-22 2003-06-30 テュラリク インコーポレイテッド Pentafluorobenzenesulfonamide and analogs
AU710173B2 (en) 1996-07-19 1999-09-16 Tularik Inc. Pentafluorobenzenesulfonamides and analogs
BR9913903A (en) 1998-09-23 2001-07-03 Tularik Inc Compound, method for treating or preventing an unhealthy condition, and pharmaceutical composition
WO2000073270A1 (en) * 1999-05-31 2000-12-07 Daiichi Pharmaceutical Co., Ltd. Remedies for periodontal diseases
DE60007310D1 (en) * 1999-06-04 2004-01-29 Elan Pharma Int Ltd COMPOSITIONS AND METHODS TO PREVENT CELL DEATH
JP2003509417A (en) 1999-09-14 2003-03-11 アルタナ ファルマ アクチエンゲゼルシャフト Tryptase inhibitor
DE19945787A1 (en) 1999-09-24 2001-03-29 Boehringer Ingelheim Pharma New 2-(amidino- or aminomethyl-phenethyl)-5-sulfonylamino-benzimidazoles, are tryptase inhibitors useful e.g. for treating inflammatory or allergic disease such as asthma, urticaria or arthritis
US6413990B1 (en) 1999-09-24 2002-07-02 Boehringer Ingelheim Pharma Kg Arylsulphonamide-substituted benzimidazoles having tryptase-inhibiting activity
CA2379557C (en) * 1999-09-24 2008-09-16 Boehringer Ingelheim Pharma Kg Arylsulphonamide-substituted benzimidazole derivatives, processes for preparing them and their use as pharmaceutical compositions
DE19945810A1 (en) * 1999-09-24 2001-03-29 Boehringer Ingelheim Pharma Substituted benzimidazole derivatives, process for their preparation and their use as medicaments
GB9923710D0 (en) * 1999-10-08 1999-12-08 Proteus Molecular Design Chemical compounds
TR200402164T4 (en) 1999-12-20 2004-10-21 Altana Pharma Ag Tryptase inhibitors
PT1358182E (en) 2001-01-31 2004-12-31 Altana Pharma Ag DERIVATIVES OF DIAZOCINES AND THEIR USE AS TRIPTASE INHIBITORS
US6656956B2 (en) 2001-02-08 2003-12-02 Boehringer Ingelheim Pharma Kg Benzimidazole derivatives, processes for preparing them and their use as pharmaceutical compositions
DE10105628A1 (en) * 2001-02-08 2002-08-22 Boehringer Ingelheim Pharma Benzimidazole derivatives, process for their preparation and their use as medicines
AU2002253026B2 (en) 2001-02-21 2007-08-09 Altana Pharma Ag Tryptase inhibitors
US7060716B2 (en) 2001-02-21 2006-06-13 Altana Pharma Ag Tryptase inhibitors
US6962941B2 (en) 2001-06-19 2005-11-08 Altana Pharma Ag Tryptase inhibitors
CA2469607A1 (en) * 2001-12-13 2003-06-19 Kowa Company, Ltd. Use of protease-activated receptor-2 inhibitor in the manifacture of a medicament for treating delayed hypersensitivity
US7049333B2 (en) 2002-06-04 2006-05-23 Sanofi-Aventis Deutschland Gmbh Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU527371B2 (en) * 1980-09-16 1983-03-03 Torii & Co., Ltd. Amidine
DE3427865A1 (en) * 1984-07-27 1986-02-06 Torii & Co., Tokio/Tokyo Amidino compounds, process for their preparation and pharmaceutical compositions containing these compounds
ATE114670T1 (en) * 1991-03-06 1994-12-15 Searle & Co PHENYLAMIDE DERIVATIVES AS PLATELET AGGREGATION INHIBITORS.
ZA928276B (en) * 1991-10-31 1993-05-06 Daiichi Seiyaku Co Aromatic amidine derivates and salts thereof.
JPH05213927A (en) * 1992-02-10 1993-08-24 Torii Yakuhin Kk Novel furancarboxylic acid amidinonaphthyl ester derivatives and acid addition salts thereof
NZ263084A (en) * 1993-03-12 1997-08-22 Arris Pharm Corp Dipeptide derivatives, treatment of immunomediated inflammatory disorders
KR100309616B1 (en) * 1993-03-12 2002-02-28 추후제출 Compositions and Methods for the Treatment of Immune Mediated Inflammatory Diseases
DE4316922A1 (en) * 1993-05-20 1994-11-24 Boehringer Mannheim Gmbh New 4-amidinophenylsulfonamides - process for their preparation and medicaments containing these compounds
EE03525B1 (en) * 1994-09-23 2001-10-15 Arris Pharmaceutical Corporation Compositions for the treatment of mast cell-mediated inflammatory conditions
WO1996020917A1 (en) * 1995-01-05 1996-07-11 Torii Pharmaceutical Co., Ltd. Substituted amidinonaphthyl ester derivatives
WO1997037969A1 (en) * 1996-04-10 1997-10-16 Ono Pharmaceutical Co., Ltd. Tryptase inhibitor and novel guanidino derivatives
EP0960102A1 (en) * 1996-07-08 1999-12-01 Du Pont Pharmaceuticals Company AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN

Also Published As

Publication number Publication date
EP1030844A1 (en) 2000-08-30
WO1999024407A1 (en) 1999-05-20

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase