ZA200604862B - Agents for treatment of glaucomatous retinopathy and optic neuropathy - Google Patents

Agents for treatment of glaucomatous retinopathy and optic neuropathy Download PDF

Info

Publication number: ZA200604862B
Authority: ZA; South Africa
Prior art keywords: pharmacologically active; optic neuropathy; agent; active derivative; cells
Prior art date: 2003-12-22

Application number

ZA200604862A

Other languages

English (en)

Inventor

Robert A Landers

Pang Iok-Hou

Original Assignee

Alcon Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-22

Filing date

2004-12-17

Publication date

2007-10-31

2004-12-17 Application filed by Alcon Inc filed Critical Alcon Inc

2007-10-31 Publication of ZA200604862B publication Critical patent/ZA200604862B/en

Links

206010061323 Optic neuropathy Diseases 0.000 title claims description 27
208000020911 optic nerve disease Diseases 0.000 title claims description 27
208000017442 Retinal disease Diseases 0.000 title claims description 23
206010038923 Retinopathy Diseases 0.000 title claims description 23
239000003795 chemical substances by application Substances 0.000 claims description 47
101000588302 Homo sapiens Nuclear factor erythroid 2-related factor 2 Proteins 0.000 claims description 33
102100031701 Nuclear factor erythroid 2-related factor 2 Human genes 0.000 claims description 33
230000005937 nuclear translocation Effects 0.000 claims description 28
SUVMJBTUFCVSAD-UHFFFAOYSA-N sulforaphane Chemical compound CS(=O)CCCCN=C=S SUVMJBTUFCVSAD-UHFFFAOYSA-N 0.000 claims description 22
230000004936 stimulating effect Effects 0.000 claims description 17
SUVMJBTUFCVSAD-JTQLQIEISA-N 4-Methylsulfinylbutyl isothiocyanate Natural products C[S@](=O)CCCCN=C=S SUVMJBTUFCVSAD-JTQLQIEISA-N 0.000 claims description 11
229960005559 sulforaphane Drugs 0.000 claims description 11
235000015487 sulforaphane Nutrition 0.000 claims description 11
LZENMJMJWQSSNJ-UHFFFAOYSA-N 3H-1,2-dithiole-3-thione Chemical compound S=C1C=CSS1 LZENMJMJWQSSNJ-UHFFFAOYSA-N 0.000 claims description 6
239000003814 drug Substances 0.000 claims description 6
238000002347 injection Methods 0.000 claims description 6
239000007924 injection Substances 0.000 claims description 6
150000002540 isothiocyanates Chemical class 0.000 claims description 6
208000024891 symptom Diseases 0.000 claims description 6
AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 claims description 4
REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims description 4
229930003935 flavonoid Natural products 0.000 claims description 4
150000002215 flavonoids Chemical class 0.000 claims description 4
235000017173 flavonoids Nutrition 0.000 claims description 4
CKNAQFVBEHDJQV-UHFFFAOYSA-N oltipraz Chemical compound S1SC(=S)C(C)=C1C1=CN=CC=N1 CKNAQFVBEHDJQV-UHFFFAOYSA-N 0.000 claims description 4
229950008687 oltipraz Drugs 0.000 claims description 4
230000000699 topical effect Effects 0.000 claims description 4
239000004258 Ethoxyquin Substances 0.000 claims description 3
238000006845 Michael addition reaction Methods 0.000 claims description 3
235000019282 butylated hydroxyanisole Nutrition 0.000 claims description 3
CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims description 3
DECIPOUIJURFOJ-UHFFFAOYSA-N ethoxyquin Chemical compound N1C(C)(C)C=C(C)C2=CC(OCC)=CC=C21 DECIPOUIJURFOJ-UHFFFAOYSA-N 0.000 claims description 3
235000019285 ethoxyquin Nutrition 0.000 claims description 3
229940093500 ethoxyquin Drugs 0.000 claims description 3
XKZQKPRCPNGNFR-UHFFFAOYSA-N 2-(3-hydroxyphenyl)phenol Chemical compound OC1=CC=CC(C=2C(=CC=CC=2)O)=C1 XKZQKPRCPNGNFR-UHFFFAOYSA-N 0.000 claims description 2
239000004255 Butylated hydroxyanisole Substances 0.000 claims description 2
NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims description 2
ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 claims description 2
HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 claims description 2
GNVMUORYQLCPJZ-UHFFFAOYSA-M Thiocarbamate Chemical compound NC([S-])=O GNVMUORYQLCPJZ-UHFFFAOYSA-M 0.000 claims description 2
229940043253 butylated hydroxyanisole Drugs 0.000 claims description 2
235000010354 butylated hydroxytoluene Nutrition 0.000 claims description 2
238000002513 implantation Methods 0.000 claims description 2
MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims description 2
229960001285 quercetin Drugs 0.000 claims description 2
235000005875 quercetin Nutrition 0.000 claims description 2
GOLORTLGFDVFDW-UHFFFAOYSA-N 3-(1h-benzimidazol-2-yl)-7-(diethylamino)chromen-2-one Chemical compound C1=CC=C2NC(C3=CC4=CC=C(C=C4OC3=O)N(CC)CC)=NC2=C1 GOLORTLGFDVFDW-UHFFFAOYSA-N 0.000 claims 1
210000004027 cell Anatomy 0.000 description 30
210000003994 retinal ganglion cell Anatomy 0.000 description 23
108090000623 proteins and genes Proteins 0.000 description 21
239000000203 mixture Substances 0.000 description 15
231100000433 cytotoxic Toxicity 0.000 description 13
230000001472 cytotoxic effect Effects 0.000 description 13
239000002207 metabolite Substances 0.000 description 12
238000000034 method Methods 0.000 description 11
208000010412 Glaucoma Diseases 0.000 description 9
230000002207 retinal effect Effects 0.000 description 9
108700032225 Antioxidant Response Elements Proteins 0.000 description 8
238000009472 formulation Methods 0.000 description 8
239000000243 solution Substances 0.000 description 8
102000004190 Enzymes Human genes 0.000 description 7
108090000790 Enzymes Proteins 0.000 description 7
150000001875 compounds Chemical class 0.000 description 7
229940088598 enzyme Drugs 0.000 description 7
210000001525 retina Anatomy 0.000 description 7
241000700159 Rattus Species 0.000 description 6
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
230000001988 toxicity Effects 0.000 description 6
231100000419 toxicity Toxicity 0.000 description 6
108091003079 Bovine Serum Albumin Proteins 0.000 description 5
239000006144 Dulbecco’s modiﬁed Eagle's medium Substances 0.000 description 5
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 5
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 5
229930195712 glutamate Natural products 0.000 description 5
239000002609 medium Substances 0.000 description 5
210000001328 optic nerve Anatomy 0.000 description 5
235000018102 proteins Nutrition 0.000 description 5
102000004169 proteins and genes Human genes 0.000 description 5
230000004083 survival effect Effects 0.000 description 5
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
MJKVTPMWOKAVMS-UHFFFAOYSA-N 3-hydroxy-1-benzopyran-2-one Chemical compound C1=CC=C2OC(=O)C(O)=CC2=C1 MJKVTPMWOKAVMS-UHFFFAOYSA-N 0.000 description 4
239000012039 electrophile Substances 0.000 description 4
239000003623 enhancer Substances 0.000 description 4
230000014509 gene expression Effects 0.000 description 4
230000006698 induction Effects 0.000 description 4
210000004379 membrane Anatomy 0.000 description 4
239000012528 membrane Substances 0.000 description 4
230000001537 neural effect Effects 0.000 description 4
210000000844 retinal pigment epithelial cell Anatomy 0.000 description 4
208000003098 Ganglion Cysts Diseases 0.000 description 3
108090000526 Papain Proteins 0.000 description 3
239000004365 Protease Substances 0.000 description 3
208000005400 Synovial Cyst Diseases 0.000 description 3
101150052863 THY1 gene Proteins 0.000 description 3
239000000370 acceptor Substances 0.000 description 3
230000001086 cytosolic effect Effects 0.000 description 3
238000001784 detoxification Methods 0.000 description 3
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
230000000694 effects Effects 0.000 description 3
230000000670 limiting effect Effects 0.000 description 3
210000002569 neuron Anatomy 0.000 description 3
229940054534 ophthalmic solution Drugs 0.000 description 3
229940055729 papain Drugs 0.000 description 3
235000019834 papain Nutrition 0.000 description 3
230000008569 process Effects 0.000 description 3
230000001681 protective effect Effects 0.000 description 3
239000008213 purified water Substances 0.000 description 3
210000003583 retinal pigment epithelium Anatomy 0.000 description 3
239000011780 sodium chloride Substances 0.000 description 3
-1 sulforaphane Chemical class 0.000 description 3
230000009885 systemic effect Effects 0.000 description 3
210000001519 tissue Anatomy 0.000 description 3
241000283690 Bos taurus Species 0.000 description 2
UBJVUCKUDDKUJF-UHFFFAOYSA-N Diallyl sulfide Chemical compound C=CCSCC=C UBJVUCKUDDKUJF-UHFFFAOYSA-N 0.000 description 2
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
102000005720 Glutathione transferase Human genes 0.000 description 2
108010070675 Glutathione transferase Proteins 0.000 description 2
241001465754 Metazoa Species 0.000 description 2
210000002403 aortic endothelial cell Anatomy 0.000 description 2
210000003050 axon Anatomy 0.000 description 2
230000008512 biological response Effects 0.000 description 2
229940098773 bovine serum albumin Drugs 0.000 description 2
239000000969 carrier Substances 0.000 description 2
239000006285 cell suspension Substances 0.000 description 2
VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 description 2
230000034994 death Effects 0.000 description 2
238000011161 development Methods 0.000 description 2
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
201000010099 disease Diseases 0.000 description 2
229940078469 dl- cysteine Drugs 0.000 description 2
125000006575 electron-withdrawing group Chemical group 0.000 description 2
239000000284 extract Substances 0.000 description 2
239000012091 fetal bovine serum Substances 0.000 description 2
RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
RYBJNWIQNLZNPE-UHFFFAOYSA-N isothiocyanatomethylcyclohexane Chemical compound S=C=NCC1CCCCC1 RYBJNWIQNLZNPE-UHFFFAOYSA-N 0.000 description 2
230000007246 mechanism Effects 0.000 description 2
230000001404 mediated effect Effects 0.000 description 2
125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 description 2
239000002674 ointment Substances 0.000 description 2
239000002997 ophthalmic solution Substances 0.000 description 2
239000007800 oxidant agent Substances 0.000 description 2
231100000915 pathological change Toxicity 0.000 description 2
230000036285 pathological change Effects 0.000 description 2
150000002978 peroxides Chemical class 0.000 description 2
IZJDOKYDEWTZSO-UHFFFAOYSA-N phenethyl isothiocyanate Chemical compound S=C=NCCC1=CC=CC=C1 IZJDOKYDEWTZSO-UHFFFAOYSA-N 0.000 description 2
239000002953 phosphate buffered saline Substances 0.000 description 2
239000003755 preservative agent Substances 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
210000000278 spinal cord Anatomy 0.000 description 2
238000012453 sprague-dawley rat model Methods 0.000 description 2
UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
239000004094 surface-active agent Substances 0.000 description 2
230000000007 visual effect Effects 0.000 description 2
IAKPHLATFBHGOB-UHFFFAOYSA-M 1,1'-dioctadecyl-3,3,3'3'-tetramethylindocarbocyanine perchlorate Chemical compound [O-]Cl(=O)(=O)=O.CC1(C)C2=CC=CC=C2N(CCCCCCCCCCCCCCCCC)\C1=C/C=C/C1=[N+](CCCCCCCCCCCCCCCCC)C2=CC=CC=C2C1(C)C IAKPHLATFBHGOB-UHFFFAOYSA-M 0.000 description 1
SIQPZGADPPVYAP-UHFFFAOYSA-N 1-isothiocyanato-5-methylsulfonylpentane Chemical compound CS(=O)(=O)CCCCCN=C=S SIQPZGADPPVYAP-UHFFFAOYSA-N 0.000 description 1
GAMOIYAHFLGUMB-UHFFFAOYSA-N 1-isothiocyanatohexan-2-one Chemical compound CCCCC(=O)CN=C=S GAMOIYAHFLGUMB-UHFFFAOYSA-N 0.000 description 1
101710157142 2-methylene-furan-3-one reductase Proteins 0.000 description 1
KINDIWUSDVLKCI-UHFFFAOYSA-N 4-isothiocyanatobicyclo[2.2.1]heptane Chemical compound C1CC2CCC1(N=C=S)C2 KINDIWUSDVLKCI-UHFFFAOYSA-N 0.000 description 1
BQYLCVLIDSFGNX-UHFFFAOYSA-N 6-isothiocyanatohexan-2-ol Chemical compound CC(O)CCCCN=C=S BQYLCVLIDSFGNX-UHFFFAOYSA-N 0.000 description 1
102000007469 Actins Human genes 0.000 description 1
108010085238 Actins Proteins 0.000 description 1
208000024827 Alzheimer disease Diseases 0.000 description 1
206010003497 Asphyxia Diseases 0.000 description 1
201000004569 Blindness Diseases 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 description 1
IEPRKVQEAMIZSS-UHFFFAOYSA-N Di-Et ester-Fumaric acid Natural products CCOC(=O)C=CC(=O)OCC IEPRKVQEAMIZSS-UHFFFAOYSA-N 0.000 description 1
IEPRKVQEAMIZSS-WAYWQWQTSA-N Diethyl maleate Chemical compound CCOC(=O)\C=C/C(=O)OCC IEPRKVQEAMIZSS-WAYWQWQTSA-N 0.000 description 1
239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 1
238000001061 Dunnett's test Methods 0.000 description 1
206010018341 Gliosis Diseases 0.000 description 1
RUQCCAGSFPUGSZ-OBWQKADXSA-N Glucoraphanin Natural products C[S@](=O)CCCCC(=NS(=O)(=O)O)S[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O RUQCCAGSFPUGSZ-OBWQKADXSA-N 0.000 description 1
102000016354 Glucuronosyltransferase Human genes 0.000 description 1
108010092364 Glucuronosyltransferase Proteins 0.000 description 1
108010024636 Glutathione Proteins 0.000 description 1
108010063907 Glutathione Reductase Proteins 0.000 description 1
102100036442 Glutathione reductase, mitochondrial Human genes 0.000 description 1
229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
239000004166 Lanolin Substances 0.000 description 1
102000003960 Ligases Human genes 0.000 description 1
108090000364 Ligases Proteins 0.000 description 1
108010006519 Molecular Chaperones Proteins 0.000 description 1
HSHXDCVZWHOWCS-UHFFFAOYSA-N N'-hexadecylthiophene-2-carbohydrazide Chemical compound CCCCCCCCCCCCCCCCNNC(=O)c1cccs1 HSHXDCVZWHOWCS-UHFFFAOYSA-N 0.000 description 1
102000004960 NAD(P)H dehydrogenase (quinone) Human genes 0.000 description 1
108020000284 NAD(P)H dehydrogenase (quinone) Proteins 0.000 description 1
108010038349 NF-E2 Transcription Factor Proteins 0.000 description 1
102000010731 NF-E2 Transcription Factor Human genes 0.000 description 1
108010025020 Nerve Growth Factor Proteins 0.000 description 1
102000007072 Nerve Growth Factors Human genes 0.000 description 1
208000028389 Nerve injury Diseases 0.000 description 1
229930182555 Penicillin Natural products 0.000 description 1
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
229920002685 Polyoxyl 35CastorOil Polymers 0.000 description 1
102000004245 Proteasome Endopeptidase Complex Human genes 0.000 description 1
108090000708 Proteasome Endopeptidase Complex Proteins 0.000 description 1
VSWDORGPIHIGNW-UHFFFAOYSA-N Pyrrolidine dithiocarbamic acid Chemical compound SC(=S)N1CCCC1 VSWDORGPIHIGNW-UHFFFAOYSA-N 0.000 description 1
101710189291 Quinone oxidoreductase Proteins 0.000 description 1
102100034576 Quinone oxidoreductase Human genes 0.000 description 1
102000009661 Repressor Proteins Human genes 0.000 description 1
108010034634 Repressor Proteins Proteins 0.000 description 1
QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 description 1
229920002125 Sokalan® Polymers 0.000 description 1
101710127774 Stress response protein Proteins 0.000 description 1
BGNXCDMCOKJUMV-UHFFFAOYSA-N Tert-Butylhydroquinone Chemical compound CC(C)(C)C1=CC(O)=CC=C1O BGNXCDMCOKJUMV-UHFFFAOYSA-N 0.000 description 1
LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 description 1
108091023040 Transcription factor Proteins 0.000 description 1
102000040945 Transcription factor Human genes 0.000 description 1
102000044159 Ubiquitin Human genes 0.000 description 1
108090000848 Ubiquitin Proteins 0.000 description 1
208000027418 Wounds and injury Diseases 0.000 description 1
GMMLNKINDDUDCF-JRWRFYLSSA-N [(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1e)-5-[(r)-methylsulfinyl]-n-sulfooxypentanimidothioate Chemical compound C[S@@](=O)CCCC\C(=N/OS(O)(=O)=O)S[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GMMLNKINDDUDCF-JRWRFYLSSA-N 0.000 description 1
XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 1
230000002159 abnormal effect Effects 0.000 description 1
239000002253 acid Substances 0.000 description 1
150000001336 alkenes Chemical class 0.000 description 1
150000001408 amides Chemical class 0.000 description 1
206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 1
238000000540 analysis of variance Methods 0.000 description 1
230000001384 anti-glaucoma Effects 0.000 description 1
230000006907 apoptotic process Effects 0.000 description 1
239000012062 aqueous buffer Substances 0.000 description 1
229960001716 benzalkonium Drugs 0.000 description 1
229960000686 benzalkonium chloride Drugs 0.000 description 1
ZYGHJZDHTFUPRJ-UHFFFAOYSA-N benzo-alpha-pyrone Natural products C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 1
CYDRXTMLKJDRQH-UHFFFAOYSA-N benzododecinium Chemical compound CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 CYDRXTMLKJDRQH-UHFFFAOYSA-N 0.000 description 1
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
210000004556 brain Anatomy 0.000 description 1
210000005013 brain tissue Anatomy 0.000 description 1
239000000872 buffer Substances 0.000 description 1
150000001728 carbonyl compounds Chemical class 0.000 description 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
239000013592 cell lysate Substances 0.000 description 1
230000007541 cellular toxicity Effects 0.000 description 1
210000003161 choroid Anatomy 0.000 description 1
235000001671 coumarin Nutrition 0.000 description 1
150000004775 coumarins Chemical class 0.000 description 1
229940109262 curcumin Drugs 0.000 description 1
235000012754 curcumin Nutrition 0.000 description 1
239000004148 curcumin Substances 0.000 description 1
235000018417 cysteine Nutrition 0.000 description 1
210000000805 cytoplasm Anatomy 0.000 description 1
210000004292 cytoskeleton Anatomy 0.000 description 1
230000003013 cytotoxicity Effects 0.000 description 1
231100000135 cytotoxicity Toxicity 0.000 description 1
230000006378 damage Effects 0.000 description 1
230000000254 damaging effect Effects 0.000 description 1
230000007123 defense Effects 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
230000001934 delay Effects 0.000 description 1
229940061607 dibasic sodium phosphate Drugs 0.000 description 1
VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 description 1
LDCRTTXIJACKKU-ONEGZZNKSA-N dimethyl fumarate Chemical compound COC(=O)\C=C\C(=O)OC LDCRTTXIJACKKU-ONEGZZNKSA-N 0.000 description 1
229960004419 dimethyl fumarate Drugs 0.000 description 1
235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 1
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
210000003717 douglas' pouch Anatomy 0.000 description 1
229940079593 drug Drugs 0.000 description 1
230000002500 effect on skin Effects 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
239000003885 eye ointment Substances 0.000 description 1
239000012894 fetal calf serum Substances 0.000 description 1
239000000835 fiber Substances 0.000 description 1
239000007850 fluorescent dye Substances 0.000 description 1
125000000524 functional group Chemical group 0.000 description 1
210000002592 gangliocyte Anatomy 0.000 description 1
239000000499 gel Substances 0.000 description 1
239000011521 glass Substances 0.000 description 1
230000007387 gliosis Effects 0.000 description 1
125000004383 glucosinolate group Chemical group 0.000 description 1
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
229960003180 glutathione Drugs 0.000 description 1
208000035474 group of disease Diseases 0.000 description 1
LHGVFZTZFXWLCP-UHFFFAOYSA-N guaiacol Chemical class COC1=CC=CC=C1O LHGVFZTZFXWLCP-UHFFFAOYSA-N 0.000 description 1
230000036541 health Effects 0.000 description 1
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
229920003063 hydroxymethyl cellulose Polymers 0.000 description 1
229940031574 hydroxymethyl cellulose Drugs 0.000 description 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
238000003119 immunoblot Methods 0.000 description 1
238000003365 immunocytochemistry Methods 0.000 description 1
239000007943 implant Substances 0.000 description 1
238000011534 incubation Methods 0.000 description 1
239000000411 inducer Substances 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
230000003993 interaction Effects 0.000 description 1
239000007927 intramuscular injection Substances 0.000 description 1
238000010255 intramuscular injection Methods 0.000 description 1
230000004410 intraocular pressure Effects 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
230000007794 irritation Effects 0.000 description 1
208000028867 ischemia Diseases 0.000 description 1
229940039717 lanolin Drugs 0.000 description 1
235000019388 lanolin Nutrition 0.000 description 1
239000007788 liquid Substances 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
239000003550 marker Substances 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
235000010446 mineral oil Nutrition 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000009456 molecular mechanism Effects 0.000 description 1
239000003068 molecular probe Substances 0.000 description 1
ODLHGICHYURWBS-FOSILIAISA-N molport-023-220-444 Chemical compound CC(O)COC[C@@H]([C@@H]([C@H]([C@@H]1O)O)O[C@@H]2O[C@H]([C@H](O[C@@H]3O[C@@H](COCC(C)O)[C@@H]([C@H]([C@@H]3O)O)O[C@@H]3O[C@@H](COCC(C)O)[C@@H]([C@H]([C@@H]3O)O)O[C@@H]3O[C@@H](COCC(C)O)[C@@H]([C@H]([C@@H]3O)O)O[C@@H]3O[C@@H](COCC(C)O)[C@@H]([C@H]([C@@H]3O)O)O3)[C@@H](O)[C@@H]2O)COCC(O)C)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O)[C@H]3O[C@H]1COCC(C)O ODLHGICHYURWBS-FOSILIAISA-N 0.000 description 1
229940045641 monobasic sodium phosphate Drugs 0.000 description 1
229910000403 monosodium phosphate Inorganic materials 0.000 description 1
235000019799 monosodium phosphate Nutrition 0.000 description 1
230000008764 nerve damage Effects 0.000 description 1
230000004770 neurodegeneration Effects 0.000 description 1
208000015122 neurodegenerative disease Diseases 0.000 description 1
239000003900 neurotrophic factor Substances 0.000 description 1
150000002825 nitriles Chemical class 0.000 description 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
235000015097 nutrients Nutrition 0.000 description 1
238000001543 one-way ANOVA Methods 0.000 description 1
229940100655 ophthalmic gel Drugs 0.000 description 1
229940069265 ophthalmic ointment Drugs 0.000 description 1
229940100654 ophthalmic suspension Drugs 0.000 description 1
230000001590 oxidative effect Effects 0.000 description 1
230000036542 oxidative stress Effects 0.000 description 1
QUANRIQJNFHVEU-UHFFFAOYSA-N oxirane;propane-1,2,3-triol Chemical compound C1CO1.OCC(O)CO QUANRIQJNFHVEU-UHFFFAOYSA-N 0.000 description 1
230000037361 pathway Effects 0.000 description 1
230000035515 penetration Effects 0.000 description 1
229940049954 penicillin Drugs 0.000 description 1
235000019271 petrolatum Nutrition 0.000 description 1
230000036470 plasma concentration Effects 0.000 description 1
239000008389 polyethoxylated castor oil Substances 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
229940068968 polysorbate 80 Drugs 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
239000002243 precursor Substances 0.000 description 1
238000004321 preservation Methods 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
230000000750 progressive effect Effects 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
230000002633 protecting effect Effects 0.000 description 1
239000000700 radioactive tracer Substances 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
230000008439 repair process Effects 0.000 description 1
230000004044 response Effects 0.000 description 1
235000021283 resveratrol Nutrition 0.000 description 1
229940016667 resveratrol Drugs 0.000 description 1
210000004761 scalp Anatomy 0.000 description 1
210000003786 sclera Anatomy 0.000 description 1
210000003625 skull Anatomy 0.000 description 1
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
229960005322 streptomycin Drugs 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
210000003863 superior colliculi Anatomy 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
239000000725 suspension Substances 0.000 description 1
238000007910 systemic administration Methods 0.000 description 1
239000004250 tert-Butylhydroquinone Substances 0.000 description 1
235000019281 tert-butylhydroquinone Nutrition 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
238000011287 therapeutic dose Methods 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
150000003558 thiocarbamic acid derivatives Chemical class 0.000 description 1
125000003396 thiol group Chemical group [H]S* 0.000 description 1
238000002723 toxicity assay Methods 0.000 description 1
239000003053 toxin Substances 0.000 description 1
238000013518 transcription Methods 0.000 description 1
230000035897 transcription Effects 0.000 description 1
230000002103 transcriptional effect Effects 0.000 description 1
230000005945 translocation Effects 0.000 description 1
230000032258 transport Effects 0.000 description 1
210000001782 transverse sinus Anatomy 0.000 description 1
230000006496 vascular abnormality Effects 0.000 description 1
210000003556 vascular endothelial cell Anatomy 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
239000003871 white petrolatum Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Ophthalmology & Optometry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Dermatology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Steroid Compounds (AREA)
Pyrrole Compounds (AREA)
Quinoline Compounds (AREA)
Pyrane Compounds (AREA)
Saccharide Compounds (AREA)

ZA200604862A 2003-12-22 2004-12-17 Agents for treatment of glaucomatous retinopathy and optic neuropathy ZA200604862B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US53177003P	2003-12-22	2003-12-22

Publications (1)

Publication Number	Publication Date
ZA200604862B true ZA200604862B (en)	2007-10-31

Family

ID=34738696

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200604862A ZA200604862B (en)	2003-12-22	2004-12-17	Agents for treatment of glaucomatous retinopathy and optic neuropathy

Country Status (19)

Country	Link
US (2)	US20050137146A1 (fr)
EP (2)	EP1803468B1 (fr)
JP (2)	JP4755599B2 (fr)
KR (1)	KR20060127043A (fr)
CN (1)	CN1897972A (fr)
AT (2)	ATE357932T1 (fr)
AU (1)	AU2004308919B2 (fr)
BR (1)	BRPI0417987A (fr)
CA (1)	CA2547852A1 (fr)
CY (2)	CY1106623T1 (fr)
DE (1)	DE602004005617T2 (fr)
DK (2)	DK1696958T3 (fr)
ES (2)	ES2282926T3 (fr)
MX (1)	MXPA06006980A (fr)
PL (2)	PL1803468T3 (fr)
PT (2)	PT1696958E (fr)
SI (2)	SI1696958T1 (fr)
WO (1)	WO2005063295A1 (fr)
ZA (1)	ZA200604862B (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6881198B2 (en) *	2001-01-09	2005-04-19	J. David Brown	Glaucoma treatment device and method
PL1803468T3 (pl) *	2003-12-22	2012-05-31	Novartis Ag	Środki do leczenia retinopatii jaskrowej i neuropatii wzrokowej
WO2005102345A1 (fr) *	2004-03-30	2005-11-03	Alcon, Inc.	Utilisation d'inhibiteurs de kinase rho dans le traitement de deficits auditifs, d'acouphenes et dans l'amelioration de l'equilibre corporel
WO2006030907A1 (fr) *	2004-09-16	2006-03-23	Redox Bioscience Inc.	Agent de protection de la rétine
WO2007035356A2 (fr) *	2005-09-16	2007-03-29	Bg Implant, Inc.	Dispositifs et procedes de traitement du glaucome
WO2008016095A1 (fr) *	2006-08-02	2008-02-07	Santen Pharmaceutical Co., Ltd.	REMÈDE PRÉVENTIF OU CURATIF POUR LES KÉRATOCONJONCTIVITES CONTENANT UN ACTIVATEUR DE Nrf2 EN TANT QUE MATIÈRE ACTIVE
WO2008108825A2 (fr) *	2006-10-10	2008-09-12	Burnham Institute For Medical Research	Compositions neuroprotectrices et procédés correspondants
WO2008111497A1 (fr) *	2007-03-08	2008-09-18	Santen Pharmaceutical Co., Ltd.	Agent prophylactique ou thérapeutique pour une maladie ophtalmique associée avec un stress oxydant, comprenant un triterpénoïde comme principe actif
NZ588711A (en)	2008-04-18	2012-10-26	Reata Pharmaceuticals Inc	C-17 homologated oleanolic acid derivatives for treating cancer
LT2276493T (lt)	2008-04-18	2019-01-10	Reata Pharmaceuticals, Inc.	Antioksidaciniai uždegimo moduliatoriai: oleanolio rūgšties dariniai su amino ir kitomis modifikacijomis c-17
TW201006474A (en)	2008-04-18	2010-02-16	Reata Pharmaceuticals Inc	Natural products including an anti-flammatory pharmacore and methods of use
LT2558105T (lt)	2010-04-12	2020-02-10	Reata Pharmaceuticals, Inc.	Bardoksolono metilas, skirtas nutukimo gydymui
RU2472475C2 (ru) *	2010-04-20	2013-01-20	Учреждение образования "Белорусский государственный медицинский университет" (УО БГМУ)	Способ комбинированного лечения глаукомной оптической нейропатии
WO2012009171A2 (fr) *	2010-07-15	2012-01-19	The Schepens Eye Research Institute, Inc.	Compositions et méthodes de traitement de troubles de l'endothélium cornéen
RU2447864C1 (ru) *	2010-09-15	2012-04-20	Инна Витальевна Щербинина	Способ лечения заболеваний зрительного нерва и сетчатки
CN103702669A (zh) *	2011-06-21	2014-04-02	约翰霍普金斯大学	用于治疗周围神经病变和其他神经退行性疾患的化合物
RU2546019C2 (ru) *	2013-03-02	2015-04-10	Государственное бюджетное образовательное учреждение высшего профессионального образования "Воронежская государственная медицинская академия им. Н.Н. Бурденко" Министерства здравоохранения Российской Федерации	Способ лечения глаукомной оптической нейропатии
JP6340673B2 (ja)	2013-05-02	2018-06-13	レティナファウンデーションオブザサウスウエストＲｅｔｉｎａＦｏｕｎｄａｔｉｏｎＯｆＴｈｅＳｏｕｔｈｗｅｓｔ	二層型眼用インプラント
AU2015374033B2 (en)	2014-12-31	2020-07-02	Microoptx Inc.	Glaucoma treatment devices and methods
US10980667B2 (en)	2015-09-30	2021-04-20	Microoptx Inc.	Eye treatment devices and methods
CA3036630A1 (fr)	2016-09-12	2018-03-15	St Ip Holding Ag	Formulations de 4-methyl-5-(pyrazin-2-yl)-3h-1,2-dithiole-3-thione, formulations a gout modifie, et leurs procedes de fabrication et d'utilisation
EP3509642A1 (fr)	2016-09-12	2019-07-17	ST IP Holding AG	Formulations de 4-méthyl-5-(pyrazine-2-yl)-3 h-1,2-dithiole-3-thione, et leurs procédés de fabrication et d'utilisation
US10953020B2 (en)	2016-11-08	2021-03-23	Reata Pharmaceuticals, Inc.	Methods of treating Alport syndrome using bardoxolone methyl or analogs thereof
RU2647324C1 (ru) *	2017-04-24	2018-03-15	Игорь Евгеньевич Хаценко	Способ определения показаний для лечения амблиопии с помощью нейропептидного препарата
KR20230015891A (ko) *	2020-03-30	2023-01-31	우한 뉴로프스 바이오테크놀로지 리미티드 컴퍼니	인간 핵 인자 e2-관련 인자 2의 발현 벡터 및 발현 벡터의 적용
US11135220B1 (en)	2020-04-08	2021-10-05	St Ip Holding Ag	Methods of treating viral infections with formulated compositions comprising 4-methyl-5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4456757A (en) *	1981-03-20	1984-06-26	Asahi Kasei Kogyo Kabushiki Kaisha	Isoquinolinesulfonyl derivatives and process for the preparation thereof
US4678783B1 (en) *	1983-11-04	1995-04-04	Asahi Chemical Ind	Substituted isoquinolinesulfonyl compounds
US4959389A (en) *	1987-10-19	1990-09-25	Speiser Peter P	Pharmaceutical preparation for the treatment of psoriatic arthritis
US5124154A (en) *	1990-06-12	1992-06-23	Insite Vision Incorporated	Aminosteroids for ophthalmic use
AU689036B2 (en) *	1995-05-10	1998-03-19	Kureha Chemical Industry Co., Ltd.	Pharmaceutical composition containing substance inhibiting HSP47 production
JP3193301B2 (ja) *	1995-09-14	2001-07-30	麒麟麦酒株式会社	生理活性タンパク質ｐ１６０
US5906819A (en) *	1995-11-20	1999-05-25	Kirin Beer Kabushiki Kaisha	Rho target protein Rho-kinase
US5681854A (en) *	1995-11-22	1997-10-28	Alcon Laboratories, Inc.	Use of aliphatic carboxylic acid derivatives in ophthalmic disorders
US6271224B1 (en) *	1995-12-21	2001-08-07	Alcon Laboratories, Inc.	Use of certain isoquinolinesulfonyl compounds for the treatment of glaucoma and ocular ischemia
DE69724108T2 (de) *	1996-02-02	2004-06-09	D.Western Therapeutics Institute, Nagoya	Isochinolinderivate und arzneimittel
US6586425B2 (en) *	1996-02-21	2003-07-01	Wisconsin Alumni Research Foundation	Cytoskeletal active agents for glaucoma therapy
JP3872834B2 (ja) *	1996-03-04	2007-01-24	第一製薬株式会社	メイラード反応抑制剤
BR9711154A (pt) *	1996-08-12	1999-08-17	Yoshitomi Pharmaceutical	Agente farmac-utico contendo inibidor cinase rho
US5759787A (en) *	1996-08-26	1998-06-02	Tularik Inc.	Kinase assay
DE69822806T2 (de) *	1997-01-16	2005-03-10	University of Florida Research Foundation, Inc., Gainesville	Zusammensetzungen zur verstärkung zytoprotektiver wirkung von polycyclischer phenolverbindungen durch synergistiche wechselwirkung von antioxidationsmitteln
US6573044B1 (en) *	1997-08-07	2003-06-03	The Regents Of The University Of California	Methods of using chemical libraries to search for new kinase inhibitors
US6441033B1 (en) *	1997-12-22	2002-08-27	Alcon Manufacturing, Ltd.	11β-fluoro 15β-hydroxy PGF2α analogs as FP receptor antagonists
US6274338B1 (en) *	1998-02-24	2001-08-14	President And Fellows Of Harvard College	Human c-Maf compositions and methods of use thereof
AU2440599A (en) *	1998-02-25	1999-09-15	Shionogi & Co., Ltd.	Therapeutic agent for complication of diabetes
US20010041174A1 (en) *	1998-11-24	2001-11-15	Najam Sharif	Use of implanted encapsulated cells expressing glutamate transporter proteins for the treatment of neurodegenerative diseases
US6020383A (en) *	1999-01-11	2000-02-01	Eastman Chemicals Company	Method for reducing blood cholesterol and/or blood triglycerides
US6103756A (en) *	1999-08-11	2000-08-15	Vitacost Inc.	Ocular orally ingested composition for prevention and treatment of individuals
US6573299B1 (en) *	1999-09-20	2003-06-03	Advanced Medical Instruments	Method and compositions for treatment of the aging eye
WO2002002190A2 (fr) *	2000-07-05	2002-01-10	Johns Hopkins School Of Medicine	Prevention et traitement de maladies degeneratives par le glutathion et des enzymes de detoxification de phase ii
GB0030727D0 (en) *	2000-12-15	2001-01-31	Lumitech Uk Ltd	Methods and kits for detecting kinase activity
US6756063B2 (en) *	2001-03-29	2004-06-29	Zoltan Laboratories, Llc	Methods and compositions for the treatment of human and animal cancers
CA2357265C (fr) *	2001-04-24	2004-04-13	University Of British Columbia	Additif ameliore pour aliments du betail
US6884816B2 (en) *	2001-08-31	2005-04-26	Alcon, Inc.	Hydroxy substituted fused naphthyl-azoles and fused indeno-azoles and their use for the treatment of glaucoma
TW201041580A (en) *	2001-09-27	2010-12-01	Alcon Inc	Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
US7199122B2 (en) *	2001-10-02	2007-04-03	Fox Chase Cancer Center	Methods for inhibiting angiogenesis
AU2002357311A1 (en) *	2001-12-18	2003-06-30	Johns Hopkins University School Of Medicine	Prevention and treatment of oxidative stress disorders by glutathione and phase ii detoxification enzymes
EP1476143A1 (fr) *	2002-02-15	2004-11-17	DSM IP Assets B.V.	Compositions comportant du lycopene destinees au traitement et a la prevention des pathologies associees a l'angiogenese
US20030219846A1 (en) *	2002-02-28	2003-11-27	Pfizer Inc.	Assay for activity of the ActRIIB kinase
WO2004012677A2 (fr) *	2002-08-05	2004-02-12	Wackvom, Ltd.	Procedes et compositions pour le traitement d'etats associes a la neovascularisation
US6747025B1 (en) *	2002-11-27	2004-06-08	Allergan, Inc.	Kinase inhibitors for the treatment of disease
TW200526224A (en) *	2003-12-22	2005-08-16	Alcon Inc	Short form c-Maf transcription factor antagonists for treatment of glaucoma
ZA200605378B (en) *	2003-12-22	2008-01-30	Alcon Inc	Agents for treatment of diabetic retinopathy and drusen formation in macular degeneration
PL1803468T3 (pl) *	2003-12-22	2012-05-31	Novartis Ag	Środki do leczenia retinopatii jaskrowej i neuropatii wzrokowej

2004
- 2004-12-17 PL PL07105047T patent/PL1803468T3/pl unknown
- 2004-12-17 ZA ZA200604862A patent/ZA200604862B/en unknown
- 2004-12-17 BR BRPI0417987-0A patent/BRPI0417987A/pt not_active IP Right Cessation
- 2004-12-17 SI SI200430296T patent/SI1696958T1/sl unknown
- 2004-12-17 KR KR1020067014097A patent/KR20060127043A/ko not_active Ceased
- 2004-12-17 DK DK04814825T patent/DK1696958T3/da active
- 2004-12-17 CN CNA2004800384580A patent/CN1897972A/zh active Pending
- 2004-12-17 ES ES04814825T patent/ES2282926T3/es not_active Expired - Lifetime
- 2004-12-17 EP EP07105047A patent/EP1803468B1/fr not_active Expired - Lifetime
- 2004-12-17 MX MXPA06006980A patent/MXPA06006980A/es active IP Right Grant
- 2004-12-17 PT PT04814825T patent/PT1696958E/pt unknown
- 2004-12-17 AT AT04814825T patent/ATE357932T1/de active
- 2004-12-17 AT AT07105047T patent/ATE523208T1/de active
- 2004-12-17 WO PCT/US2004/042687 patent/WO2005063295A1/fr not_active Ceased
- 2004-12-17 US US11/015,888 patent/US20050137146A1/en not_active Abandoned
- 2004-12-17 SI SI200431767T patent/SI1803468T1/sl unknown
- 2004-12-17 AU AU2004308919A patent/AU2004308919B2/en not_active Ceased
- 2004-12-17 PL PL04814825T patent/PL1696958T3/pl unknown
- 2004-12-17 CA CA002547852A patent/CA2547852A1/fr not_active Abandoned
- 2004-12-17 DK DK07105047.0T patent/DK1803468T3/da active
- 2004-12-17 PT PT07105047T patent/PT1803468E/pt unknown
- 2004-12-17 ES ES07105047T patent/ES2371364T3/es not_active Expired - Lifetime
- 2004-12-17 EP EP04814825A patent/EP1696958B1/fr not_active Expired - Lifetime
- 2004-12-17 DE DE602004005617T patent/DE602004005617T2/de not_active Expired - Lifetime
- 2004-12-17 JP JP2006545535A patent/JP4755599B2/ja not_active Expired - Fee Related
2007
- 2007-05-25 CY CY20071100711T patent/CY1106623T1/el unknown
2010
- 2010-11-04 JP JP2010247809A patent/JP2011046736A/ja not_active Withdrawn
2011
- 2011-02-22 US US13/031,742 patent/US20110144127A1/en not_active Abandoned
- 2011-11-24 CY CY20111101143T patent/CY1112393T1/el unknown

Also Published As

Publication number	Publication date
EP1803468B1 (fr)	2011-09-07
JP2011046736A (ja)	2011-03-10
PL1696958T3 (pl)	2007-08-31
ATE523208T1 (de)	2011-09-15
CN1897972A (zh)	2007-01-17
SI1803468T1 (sl)	2011-12-30
EP1696958B1 (fr)	2007-03-28
PL1803468T3 (pl)	2012-05-31
DE602004005617T2 (de)	2007-12-13
EP1696958A1 (fr)	2006-09-06
DE602004005617D1 (de)	2007-05-10
CY1106623T1 (el)	2012-01-25
WO2005063295A1 (fr)	2005-07-14
CY1112393T1 (el)	2015-12-09
AU2004308919A1 (en)	2005-07-14
DK1803468T3 (da)	2011-12-05
HK1097179A1 (en)	2007-06-22
KR20060127043A (ko)	2006-12-11
SI1696958T1 (sl)	2007-08-31
ES2282926T3 (es)	2007-10-16
BRPI0417987A (pt)	2007-04-27
US20050137146A1 (en)	2005-06-23
JP4755599B2 (ja)	2011-08-24
ES2371364T3 (es)	2011-12-30
EP1803468A1 (fr)	2007-07-04
AU2004308919B2 (en)	2009-11-12
ATE357932T1 (de)	2007-04-15
DK1696958T3 (da)	2007-07-09
US20110144127A1 (en)	2011-06-16
MXPA06006980A (es)	2006-12-14
PT1803468E (pt)	2011-11-23
CA2547852A1 (fr)	2005-07-14
JP2007515423A (ja)	2007-06-14
HK1110772A1 (en)	2008-07-25
PT1696958E (pt)	2007-06-04

Publication	Publication Date	Title
AU2004308919B2 (en)	2009-11-12	Agents for treatment of glaucomatous retinopathy and optic neuropathy
US7625927B2 (en)	2009-12-01	Method of treating glaucoma
US20100204244A1 (en)	2010-08-12	Agents for treatment of diabetic retinopathy and drusen formation in macular degeneration
US20100273892A1 (en)	2010-10-28	Formulations of tocotrienol quinones for the treatment of ophthalmic diseases
CN102985083A (zh)	2013-03-20	治疗眼科疾病的醌类的制剂
US11850213B2 (en)	2023-12-26	Ophthalmic compositions of rifamycins and uses thereof
HK1097179B (en)	2007-10-05	Agents for treatment of glaucomatous retinopathy and optic neuropathy
HK1110772B (en)	2011-12-09	Agents for treatment of glaucomatours retinopathy and optic neuropathy
Koide et al.	2006	Ascorbic acid concentration in rabbit vitreous measured by microdialysis with HPLC-electrochemical detection before and after vitreous surgery
KR20070015913A (ko)	2007-02-06	당뇨병성 망막병증 및 황반 변성에서의 드루젠 형성의치료용 약제
CN117982516A (zh)	2024-05-07	Skq1在抑制线粒体自噬和制备抑制线粒体自噬相关产品中的应用
US20060172977A1 (en)	2006-08-03	Method and composition for preventing, reducing and reversing ocular ischemic neuronal damage