ZA200501979B - Depot formulations of arylheterocyclic active agents in the form of a suspension - Google Patents

Depot formulations of arylheterocyclic active agents in the form of a suspension Download PDF

Info

Publication number: ZA200501979B
Authority: ZA; South Africa
Prior art keywords: ziprasidone; aryl; pharmaceutical kit; formulation; depot
Prior art date: 2002-10-25

Application number

ZA200501979A

Other languages

English (en)

Inventor

Jaymin C Shah

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-10-25

Filing date

2005-04-08

Publication date

2006-04-26

2005-04-08 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2006-04-26 Publication of ZA200501979B publication Critical patent/ZA200501979B/en

Links

239000000203 mixture Substances 0.000 title claims description 45
238000009472 formulation Methods 0.000 title claims description 38
239000000725 suspension Substances 0.000 title claims description 6
239000013543 active substance Substances 0.000 title description 5
229960000607 ziprasidone Drugs 0.000 claims description 50
MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 claims description 50
229920000858 Cyclodextrin Polymers 0.000 claims description 35
-1 B-cylcodextrin Polymers 0.000 claims description 31
239000003795 chemical substances by application Substances 0.000 claims description 25
238000002347 injection Methods 0.000 claims description 24
239000007924 injection Substances 0.000 claims description 24
239000007788 liquid Substances 0.000 claims description 22
239000002904 solvent Substances 0.000 claims description 20
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical group O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 17
230000000694 effects Effects 0.000 claims description 12
239000001913 cellulose Substances 0.000 claims description 9
229920002678 cellulose Polymers 0.000 claims description 9
150000001875 compounds Chemical class 0.000 claims description 7
238000000034 method Methods 0.000 claims description 7
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
WLQZEFFFIUHSJB-UHFFFAOYSA-N ziprasidone mesylate trihydrate Chemical group O.O.O.CS(O)(=O)=O.C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 WLQZEFFFIUHSJB-UHFFFAOYSA-N 0.000 claims description 7
230000007928 solubilization Effects 0.000 claims description 6
238000005063 solubilization Methods 0.000 claims description 6
229960004487 ziprasidone mesylate Drugs 0.000 claims description 6
235000021355 Stearic acid Nutrition 0.000 claims description 5
238000007918 intramuscular administration Methods 0.000 claims description 5
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 5
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 5
239000008180 pharmaceutical surfactant Substances 0.000 claims description 5
229920000136 polysorbate Polymers 0.000 claims description 5
239000008117 stearic acid Substances 0.000 claims description 5
239000004094 surface-active agent Substances 0.000 claims description 5
229920001577 copolymer Polymers 0.000 claims description 4
229920000515 polycarbonate Polymers 0.000 claims description 4
239000004417 polycarbonate Substances 0.000 claims description 4
239000000243 solution Substances 0.000 claims description 4
229920000954 Polyglycolide Polymers 0.000 claims description 3
229920000747 poly(lactic acid) Polymers 0.000 claims description 3
229920002101 Chitin Polymers 0.000 claims description 2
229920001661 Chitosan Polymers 0.000 claims description 2
229920002307 Dextran Polymers 0.000 claims description 2
108010010803 Gelatin Proteins 0.000 claims description 2
229920002732 Polyanhydride Polymers 0.000 claims description 2
229920001710 Polyorthoester Polymers 0.000 claims description 2
229920000615 alginic acid Polymers 0.000 claims description 2
235000010443 alginic acid Nutrition 0.000 claims description 2
239000007864 aqueous solution Substances 0.000 claims description 2
150000002170 ethers Chemical class 0.000 claims description 2
229920000159 gelatin Polymers 0.000 claims description 2
239000008273 gelatin Substances 0.000 claims description 2
235000019322 gelatine Nutrition 0.000 claims description 2
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229920000609 methyl cellulose Polymers 0.000 claims description 2
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229920001308 poly(aminoacid) Polymers 0.000 claims description 2
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229920006149 polyester-amide block copolymer Polymers 0.000 claims description 2
229920001223 polyethylene glycol Polymers 0.000 claims description 2
229920001444 polymaleic acid Polymers 0.000 claims description 2
229920000056 polyoxyethylene ether Polymers 0.000 claims description 2
229920006324 polyoxymethylene Polymers 0.000 claims description 2
229920001451 polypropylene glycol Polymers 0.000 claims description 2
229920002635 polyurethane Polymers 0.000 claims description 2
239000004814 polyurethane Substances 0.000 claims description 2
229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 2
239000001267 polyvinylpyrrolidone Substances 0.000 claims description 2
235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 2
150000003890 succinate salts Chemical class 0.000 claims description 2
239000001797 sucrose acetate isobutyrate Substances 0.000 claims description 2
235000010983 sucrose acetate isobutyrate Nutrition 0.000 claims description 2
UVGUPMLLGBCFEJ-SWTLDUCYSA-N sucrose acetate isobutyrate Chemical compound CC(C)C(=O)O[C@H]1[C@H](OC(=O)C(C)C)[C@@H](COC(=O)C(C)C)O[C@@]1(COC(C)=O)O[C@@H]1[C@H](OC(=O)C(C)C)[C@@H](OC(=O)C(C)C)[C@H](OC(=O)C(C)C)[C@@H](COC(C)=O)O1 UVGUPMLLGBCFEJ-SWTLDUCYSA-N 0.000 claims description 2
229920001897 terpolymer Polymers 0.000 claims description 2
VNDHXHMRJVTMTK-WZVRVNPQSA-H hexasodium 4-[[(1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31S,33R,35R,36R,37R,38R,39R,40R,41R,42R,43R,44R,45R,46R,47R,48R,49R)-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecahydroxy-10-(hydroxymethyl)-15,20,25,30,35-pentakis(4-sulfonatobutoxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontan-5-yl]methoxy]butane-1-sulfonate Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@H](O[C@@H]3COCCCCS([O-])(=O)=O)O[C@H]3[C@H](O)[C@@H](O)[C@H](O[C@@H]3COCCCCS([O-])(=O)=O)O[C@H]3[C@H](O)[C@@H](O)[C@H](O[C@@H]3COCCCCS([O-])(=O)=O)O[C@H]3[C@H](O)[C@@H](O)[C@H](O[C@@H]3COCCCCS([O-])(=O)=O)O[C@H]3[C@H](O)[C@@H](O)[C@H](O[C@@H]3COCCCCS([O-])(=O)=O)O[C@H]3[C@H](O)[C@@H](O)[C@H](O[C@@H]3COCCCCS([O-])(=O)=O)O[C@H]1[C@H](O)[C@H]2O VNDHXHMRJVTMTK-WZVRVNPQSA-H 0.000 claims 3
LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
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239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 1
ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims 1
229940097362 cyclodextrins Drugs 0.000 description 13
125000000623 heterocyclic group Chemical group 0.000 description 10
229940079593 drug Drugs 0.000 description 8
239000003814 drug Substances 0.000 description 8
230000002459 sustained effect Effects 0.000 description 8
150000003839 salts Chemical class 0.000 description 7
201000000980 schizophrenia Diseases 0.000 description 7
238000011282 treatment Methods 0.000 description 7
239000012729 immediate-release (IR) formulation Substances 0.000 description 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 4
239000007787 solid Substances 0.000 description 4
SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 3
125000001309 chloro group Chemical group Cl* 0.000 description 3
239000002552 dosage form Substances 0.000 description 3
239000012458 free base Substances 0.000 description 3
239000000843 powder Substances 0.000 description 3
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
208000027776 Extrapyramidal disease Diseases 0.000 description 2
241000124008 Mammalia Species 0.000 description 2
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical class CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
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239000003693 atypical antipsychotic agent Substances 0.000 description 2
238000013270 controlled release Methods 0.000 description 2
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125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
125000001153 fluoro group Chemical group F* 0.000 description 2
239000011521 glass Substances 0.000 description 2
238000011065 in-situ storage Methods 0.000 description 2
238000011866 long-term treatment Methods 0.000 description 2
ODLHGICHYURWBS-FOSILIAISA-N molport-023-220-444 Chemical compound CC(O)COC[C@@H]([C@@H]([C@H]([C@@H]1O)O)O[C@@H]2O[C@H]([C@H](O[C@@H]3O[C@@H](COCC(C)O)[C@@H]([C@H]([C@@H]3O)O)O[C@@H]3O[C@@H](COCC(C)O)[C@@H]([C@H]([C@@H]3O)O)O[C@@H]3O[C@@H](COCC(C)O)[C@@H]([C@H]([C@@H]3O)O)O[C@@H]3O[C@@H](COCC(C)O)[C@@H]([C@H]([C@@H]3O)O)O3)[C@@H](O)[C@@H]2O)COCC(O)C)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O)[C@H]3O[C@H]1COCC(C)O ODLHGICHYURWBS-FOSILIAISA-N 0.000 description 2
OIPZNTLJVJGRCI-UHFFFAOYSA-M octadecanoyloxyaluminum;dihydrate Chemical compound O.O.CCCCCCCCCCCCCCCCCC(=O)O[Al] OIPZNTLJVJGRCI-UHFFFAOYSA-M 0.000 description 2
239000003921 oil Substances 0.000 description 2
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125000004095 oxindolyl group Chemical group N1(C(CC2=CC=CC=C12)=O)* 0.000 description 2
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230000001954 sterilising effect Effects 0.000 description 2
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150000004684 trihydrates Chemical group 0.000 description 2
235000015112 vegetable and seed oil Nutrition 0.000 description 2
239000011800 void material Substances 0.000 description 2
HBVSIUZMTLDNDI-UHFFFAOYSA-N 1h-indol-2-yl hypochlorite Chemical group C1=CC=C2NC(OCl)=CC2=C1 HBVSIUZMTLDNDI-UHFFFAOYSA-N 0.000 description 1
244000201986 Cassia tora Species 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
PCKPVGOLPKLUHR-UHFFFAOYSA-N OH-Indolxyl Natural products C1=CC=C2C(O)=CNC2=C1 PCKPVGOLPKLUHR-UHFFFAOYSA-N 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
239000002253 acid Substances 0.000 description 1
238000013019 agitation Methods 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
229940124604 anti-psychotic medication Drugs 0.000 description 1
239000007900 aqueous suspension Substances 0.000 description 1
125000003118 aryl group Chemical group 0.000 description 1
229940009098 aspartate Drugs 0.000 description 1
229940127236 atypical antipsychotics Drugs 0.000 description 1
SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 description 1
125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 description 1
125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 description 1
125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 description 1
239000002775 capsule Substances 0.000 description 1
125000004093 cyano group Chemical group *C#N 0.000 description 1
150000004683 dihydrates Chemical class 0.000 description 1
201000010099 disease Diseases 0.000 description 1
238000012377 drug delivery Methods 0.000 description 1
238000002651 drug therapy Methods 0.000 description 1
230000009977 dual effect Effects 0.000 description 1
CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 description 1
230000003090 exacerbative effect Effects 0.000 description 1
VIQCGTZFEYDQMR-UHFFFAOYSA-N fluphenazine decanoate Chemical compound C1CN(CCOC(=O)CCCCCCCCC)CCN1CCCN1C2=CC(C(F)(F)F)=CC=C2SC2=CC=CC=C21 VIQCGTZFEYDQMR-UHFFFAOYSA-N 0.000 description 1
235000001727 glucose Nutrition 0.000 description 1
150000002304 glucoses Chemical class 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
150000004677 hydrates Chemical class 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 description 1
JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical compound C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 description 1
125000001041 indolyl group Chemical group 0.000 description 1
150000002692 maltoses Chemical class 0.000 description 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
229920001542 oligosaccharide Polymers 0.000 description 1
NCAIGTHBQTXTLR-UHFFFAOYSA-N phentermine hydrochloride Chemical compound [Cl-].CC(C)([NH3+])CC1=CC=CC=C1 NCAIGTHBQTXTLR-UHFFFAOYSA-N 0.000 description 1
230000036470 plasma concentration Effects 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
229940068968 polysorbate 80 Drugs 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000012453 solvate Substances 0.000 description 1
239000008227 sterile water for injection Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
229940043263 traditional drug Drugs 0.000 description 1
238000011269 treatment regimen Methods 0.000 description 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
239000008215 water for injection Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Inorganic Chemistry (AREA)
Dermatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Dispersion Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

ZA200501979A 2002-10-25 2005-04-08 Depot formulations of arylheterocyclic active agents in the form of a suspension ZA200501979B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US42129502P	2002-10-25	2002-10-25

Publications (1)

Publication Number	Publication Date
ZA200501979B true ZA200501979B (en)	2006-04-26

Family

ID=32176696

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200501979A ZA200501979B (en)	2002-10-25	2005-04-08	Depot formulations of arylheterocyclic active agents in the form of a suspension

Country Status (21)

Country	Link
US (1)	US20040146562A1 (no)
EP (1)	EP1562546A1 (no)
JP (2)	JP2006505579A (no)
KR (1)	KR20050071611A (no)
CN (1)	CN1703198A (no)
AR (1)	AR041826A1 (no)
AU (1)	AU2003267763A1 (no)
BR (1)	BR0315663A (no)
CA (1)	CA2498276A1 (no)
GT (1)	GT200300227A (no)
MX (1)	MXPA05004299A (no)
NL (1)	NL1024616C (no)
NO (1)	NO20051187L (no)
PA (1)	PA8586301A1 (no)
PE (1)	PE20040471A1 (no)
PL (1)	PL375603A1 (no)
RU (1)	RU2292207C2 (no)
TW (1)	TW200418477A (no)
UY (1)	UY28035A1 (no)
WO (1)	WO2004037224A1 (no)
ZA (1)	ZA200501979B (no)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20080113025A1 (en) *	1998-11-02	2008-05-15	Elan Pharma International Limited	Compositions comprising nanoparticulate naproxen and controlled release hydrocodone
US20040001889A1 (en)	2002-06-25	2004-01-01	Guohua Chen	Short duration depot formulations
UA79984C2 (en) *	2002-08-20	2007-08-10	Bristol Myers Squibb Co	Preparation on the basis of aripiprazole complex and use thereof
HUE026034T2 (en)	2002-12-13	2016-05-30	Durect Corp	Oral delivery system containing an oral high-viscosity carrier
BRPI0410419A (pt) *	2003-05-16	2006-05-30	Pfizer Prod Inc	tratamento para a ansiedade com ziprasidona
WO2006000913A1 (en) *	2004-06-23	2006-01-05	Pfizer Products Inc.	Method for sterile filtration of viscous pharmaceutical compositions
LT2767292T (lt) *	2004-09-17	2016-12-12	Durect Corporation	Palaikomosios vietinės anestezijos mišinys su saib
CA2598288A1 (en) *	2005-03-03	2006-09-14	Elan Pharma International Limited	Nanoparticulate compositions of heterocyclic amide derivatives
US20070027105A1 (en)	2005-07-26	2007-02-01	Alza Corporation	Peroxide removal from drug delivery vehicle
CN100391458C (zh) *	2006-02-07	2008-06-04	上海医药工业研究院	齐拉西酮或其盐包合物制备方法
CN101442985A (zh) *	2006-05-09	2009-05-27	阿斯利康(瑞典)有限公司	在其最终容器中被电离辐射灭菌了的包含质子泵抑制剂的肠胃外制剂
EP2117521B1 (en)	2006-11-03	2012-06-27	Durect Corporation	Transdermal delivery systems comprising bupivacaine
JP2011506318A (ja) *	2007-12-06	2011-03-03	デュレクトコーポレーション	経口医薬製剤
US20100260844A1 (en)	2008-11-03	2010-10-14	Scicinski Jan J	Oral pharmaceutical dosage forms
TW201521769A (zh)	2013-03-15	2015-06-16	Durect Corp	具有流變改質劑以減少溶解變異性之組成物
US12274794B2 (en)	2016-07-06	2025-04-15	Orient Pharma Co., Ltd.	Oral dosage form with drug composition, barrier layer and drug layer
US11197850B2 (en)	2017-02-23	2021-12-14	Shanghai Synergy Pharmaceutical Sciences Co., Ltd.	Powder injection of the donepezil semi palmoxiric acid salt, composition containing same and preparation method therefor
CA3167217A1 (en)	2020-01-13	2021-07-22	Durect Corporation	Sustained release drug delivery systems with reduced impurities and related methods
EP4277702A1 (en)	2021-01-12	2023-11-22	Durect Corporation	Sustained release drug delivery systems and related methods

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2688235B2 (ja) *	1987-09-07	1997-12-08	帝人株式会社	医薬物質含有脂肪乳剤の用時調製型キットおよび医薬物質含有脂肪乳剤の調製方法
GB9200247D0 (en) *	1992-01-07	1992-02-26	Erba Carlo Spa	Pharmaceutical compositions containing polymer derivative-bound anthracycline glycosides and a method for their preparation
JP3954115B2 (ja) *	1992-07-28	2007-08-08	アストラゼネカ・アクチエボラーグ	注射剤および注射剤キット
US5594141A (en) *	1994-11-23	1997-01-14	Neurogen Corporation	Certain aminomethyl biphenyl, aminomethyl phenyl pyridine and aminomethyl phenyl pyrimidine derivatives; novel dopamine receptor subtype selective ligands
US6040295A (en) *	1995-01-13	2000-03-21	Genemedicine, Inc.	Formulated nucleic acid compositions and methods of administering the same for gene therapy
UA57734C2 (uk) *	1996-05-07	2003-07-15	Пфайзер Інк.	Комплекси включення арилгетероциклічних солей
ES2224205T3 (es) *	1996-05-07	2005-03-01	Pfizer Inc.	Metodo de seleccionar una sal para la fabricacion de un complejo de ionclusion.
WO1998027963A2 (en) *	1996-12-20	1998-07-02	Alza Corporation	Gel composition and methods
PL199565B1 (pl) *	1997-05-16	2008-10-31	Amgen Inc	Preparat farmaceutyczny zawierający kompozycję o przedłużonym uwalnianiu oraz zastosowanie preparatu farmaceutycznego zawierającego kompozycję o przedłużonym uwalnianiu
UA72189C2 (uk) *	1997-11-17	2005-02-15	Янссен Фармацевтика Н.В.	Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот
KR100477782B1 (ko) *	1999-05-27	2005-03-21	화이자 프로덕츠 인코포레이티드	지프라시돈 현탁액
MY137726A (en) *	2000-11-22	2009-03-31	Nycomed Gmbh	Freeze-dried pantoprazole preparation and pantoprazole injection
EP1383445A4 (en) *	2001-03-20	2005-04-13	Cydex Inc	FORMULATIONS WITH PROPOFOL AND A SULFOALKYL ETHER CYCLODEXTRIN
EP1269994A3 (en) *	2001-06-22	2003-02-12	Pfizer Products Inc.	Pharmaceutical compositions comprising drug and concentration-enhancing polymers
US7427485B2 (en) *	2001-08-31	2008-09-23	The Rockefeller University	Method for classification of anti-psychotic drugs

2003
- 2003-10-13 PL PL03375603A patent/PL375603A1/xx not_active Application Discontinuation
- 2003-10-13 RU RU2005112202/15A patent/RU2292207C2/ru not_active IP Right Cessation
- 2003-10-13 MX MXPA05004299A patent/MXPA05004299A/es unknown
- 2003-10-13 CN CNA2003801011573A patent/CN1703198A/zh active Pending
- 2003-10-13 JP JP2004546259A patent/JP2006505579A/ja active Pending
- 2003-10-13 CA CA002498276A patent/CA2498276A1/en not_active Abandoned
- 2003-10-13 WO PCT/IB2003/004535 patent/WO2004037224A1/en not_active Ceased
- 2003-10-13 EP EP03748458A patent/EP1562546A1/en not_active Withdrawn
- 2003-10-13 AU AU2003267763A patent/AU2003267763A1/en not_active Abandoned
- 2003-10-13 KR KR1020057006963A patent/KR20050071611A/ko not_active Ceased
- 2003-10-13 BR BR0315663-0A patent/BR0315663A/pt not_active IP Right Cessation
- 2003-10-14 PA PA20038586301A patent/PA8586301A1/es unknown
- 2003-10-21 PE PE2003001065A patent/PE20040471A1/es not_active Application Discontinuation
- 2003-10-21 US US10/689,778 patent/US20040146562A1/en not_active Abandoned
- 2003-10-21 GT GT200300227A patent/GT200300227A/es unknown
- 2003-10-22 UY UY28035A patent/UY28035A1/es not_active Application Discontinuation
- 2003-10-23 AR ARP030103869A patent/AR041826A1/es unknown
- 2003-10-24 TW TW092129567A patent/TW200418477A/zh unknown
- 2003-10-24 NL NL1024616A patent/NL1024616C/nl not_active IP Right Cessation
2005
- 2005-03-04 NO NO20051187A patent/NO20051187L/no not_active Application Discontinuation
- 2005-04-08 ZA ZA200501979A patent/ZA200501979B/en unknown
2006
- 2006-05-23 JP JP2006142886A patent/JP2006219501A/ja active Pending

Also Published As

Publication number	Publication date
PE20040471A1 (es)	2004-08-14
AU2003267763A1 (en)	2004-05-13
TW200418477A (en)	2004-10-01
KR20050071611A (ko)	2005-07-07
GT200300227A (es)	2004-06-23
RU2292207C2 (ru)	2007-01-27
JP2006219501A (ja)	2006-08-24
BR0315663A (pt)	2005-08-30
UY28035A1 (es)	2004-05-31
US20040146562A1 (en)	2004-07-29
AR041826A1 (es)	2005-06-01
EP1562546A1 (en)	2005-08-17
MXPA05004299A (es)	2005-08-03
PL375603A1 (en)	2005-12-12
WO2004037224A1 (en)	2004-05-06
CA2498276A1 (en)	2004-05-06
NO20051187L (no)	2005-04-11
PA8586301A1 (es)	2004-05-07
CN1703198A (zh)	2005-11-30
JP2006505579A (ja)	2006-02-16
RU2005112202A (ru)	2005-11-20
NL1024616A1 (nl)	2004-04-27
NL1024616C (nl)	2010-04-19

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