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ZA200402697B - Antidiabetic 2-substituted-5'-O-(1-boranotriphosphate) adenosine derivatives. - Google Patents

Antidiabetic 2-substituted-5'-O-(1-boranotriphosphate) adenosine derivatives. Download PDF

Info

Publication number
ZA200402697B
ZA200402697B ZA200402697A ZA200402697A ZA200402697B ZA 200402697 B ZA200402697 B ZA 200402697B ZA 200402697 A ZA200402697 A ZA 200402697A ZA 200402697 A ZA200402697 A ZA 200402697A ZA 200402697 B ZA200402697 B ZA 200402697B
Authority
ZA
South Africa
Prior art keywords
boranotriphosphate
hydrocarbyl
compound according
insulin
diastereoisomer
Prior art date
Application number
ZA200402697A
Other languages
English (en)
Inventor
Bilha Fischer
Victoria Kleiman-Nahum
Pierre Petit
Original Assignee
Univ Bar Ilan
Univ Montpellier I
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Bar Ilan, Univ Montpellier I filed Critical Univ Bar Ilan
Publication of ZA200402697B publication Critical patent/ZA200402697B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
ZA200402697A 2001-10-24 2004-04-06 Antidiabetic 2-substituted-5'-O-(1-boranotriphosphate) adenosine derivatives. ZA200402697B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL14614201A IL146142A0 (en) 2001-10-24 2001-10-24 2-substituted-5'-o-(1-boranotriphosphate adenosine derivatives and pharmaceutical compositions comprising them for treatment of type 2 diabetes

Publications (1)

Publication Number Publication Date
ZA200402697B true ZA200402697B (en) 2005-06-06

Family

ID=11075840

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200402697A ZA200402697B (en) 2001-10-24 2004-04-06 Antidiabetic 2-substituted-5'-O-(1-boranotriphosphate) adenosine derivatives.

Country Status (10)

Country Link
US (1) US7319093B2 (fr)
EP (1) EP1446132A4 (fr)
JP (1) JP2005508970A (fr)
CN (1) CN1575180A (fr)
BR (1) BR0206190A (fr)
CA (1) CA2462250A1 (fr)
IL (1) IL146142A0 (fr)
NZ (1) NZ532171A (fr)
WO (1) WO2003034978A2 (fr)
ZA (1) ZA200402697B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7368439B2 (en) * 2005-06-15 2008-05-06 Bar - Ilan University Dinucleoside poly(borano)phosphate derivatives and uses thereof
WO2009066298A1 (fr) * 2007-11-23 2009-05-28 Bar-Ilan University Dérivés de nucléosides di- ou tri-phosphates non hydrolysables et leurs utilisations
KR101790370B1 (ko) * 2010-03-19 2017-10-25 유니버시티 오브 마이애미 췌장 베타 세포에서 인슐린 분비를 향상시키기 위한 ｐ２ｘ 퓨린성 수용체 효능제의 용도
EP2426202A1 (fr) * 2010-09-03 2012-03-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Kinases en tant que cibles pour thérapie antidiabétique
US9458463B2 (en) * 2010-09-03 2016-10-04 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Method for treatment of diabetes by a small molecule inhibitor for GRK5
EP2646449B1 (fr) * 2010-12-01 2015-08-19 Bar-Ilan University Dérivés du di- ou triphosphate d'uridine et leurs utilisations
WO2013132489A1 (fr) * 2012-03-05 2013-09-12 Bar-Ilan University Analogues de nucléoside 5'-phosphorothioate et leurs utilisations

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143907A (en) 1991-05-10 1992-09-01 Boron Biologicals, Inc. Phosphite-borane compounds, and method of making and using the same
US5434143A (en) 1991-05-10 1995-07-18 Boron Biologicals, Inc. Pharmaceutical compositions comprising phosphite-borane compounds
US5260427A (en) 1991-05-10 1993-11-09 Boron Biolgicals, Inc. Nucleosidylphosphite-borane compounds and method of making the same
US5547942A (en) 1994-01-04 1996-08-20 Rapaport; Eliezer Method of treatment of diabetes mellitus by administration of adenosine 5'-t
US5986086A (en) 1997-06-20 1999-11-16 Amersham Pharmacia Biotech Inc. Non-sulfonated cyanine dyes for labeling nucleosides and nucleotides
ATE336492T1 (de) 2000-01-14 2006-09-15 Us Gov Health & Human Serv Methonocarbacycloalkylanaloga von nucleosiden
WO2003008432A1 (fr) 2001-07-16 2003-01-30 Isis Pharmaceuticals, Inc. Procede de preparation de nucleosides triphosphates modifies en position alpha et composes obtenus conformement a ce procede

Also Published As

Publication number Publication date
CN1575180A (zh) 2005-02-02
EP1446132A4 (fr) 2006-02-15
WO2003034978A2 (fr) 2003-05-01
BR0206190A (pt) 2004-02-03
US20050065108A1 (en) 2005-03-24
IL146142A0 (en) 2002-07-25
CA2462250A1 (fr) 2003-05-01
WO2003034978A3 (fr) 2004-03-11
JP2005508970A (ja) 2005-04-07
US7319093B2 (en) 2008-01-15
EP1446132A2 (fr) 2004-08-18
NZ532171A (en) 2006-02-24

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