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ZA200300750B - 7-substituted tetracycline compounds. - Google Patents

7-substituted tetracycline compounds.

Info

Publication number
ZA200300750B
ZA200300750B ZA200300750A ZA200300750A ZA200300750B ZA 200300750 B ZA200300750 B ZA 200300750B ZA 200300750 A ZA200300750 A ZA 200300750A ZA 200300750 A ZA200300750 A ZA 200300750A ZA 200300750 B ZA200300750 B ZA 200300750B
Authority
ZA
South Africa
Prior art keywords
tetracycline compounds
substituted tetracycline
substituted
compounds
tetracycline
Prior art date
Application number
ZA200300750A
Other languages
English (en)
Inventor
Mark L Nelson
Roger Freschette
Peter Viski
Mohamed Y Ismail
Todd E Bowser
Beena Bhatia
David Messersmith
Laura Mcintyre
Darrell J Koza
Glen Rennie
Paul Sheahan
Paul Hawkins
Atul Verma
Tad Warchol
Upul Bandarage
Original Assignee
Tufts College
Paratek Pharm Innc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tufts College, Paratek Pharm Innc filed Critical Tufts College
Publication of ZA200300750B publication Critical patent/ZA200300750B/xx

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
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    • C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
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    • C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
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Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6756365B2 (en) * 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
WO1999037306A1 (fr) * 1998-01-23 1999-07-29 Trustees Of Tufts College Composes pharmaceutiquement actifs et procedes d'utilisation correspondants
US8106225B2 (en) 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
EP1666454B1 (fr) * 1999-09-14 2011-09-07 Trustees Of Tufts College Techniques de preparation de tetracyclines substituees avec des solutions chimiques a base de metal de transition
EP1263442A1 (fr) * 2000-01-24 2002-12-11 Trustees Of Tufts College COMPOSES DE TETRACYCLINE POUR LE TRAITEMENT DE TROUBLES AFFERENTS AU i CRYPTOSPORIDIUM PARVUM /i
DE60129116T2 (de) * 2000-03-31 2008-03-13 Trustees Of Tufts College, Medford 7- und 9-carbamat, harnstoff, thioharnstoff, thiocarbamat und heteroaryl-amino substituierte tetracyclinverbindungen
ATE264295T1 (de) * 2000-05-15 2004-04-15 Paratek Pharm Innc 7-substituierte kondensierte ring-tetrazyclin- verbindungen
US20040224927A1 (en) 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
AU2001268475A1 (en) 2000-06-16 2002-01-02 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
US20020132798A1 (en) 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
EA201000496A1 (ru) 2000-07-07 2010-10-29 Трастис Оф Тафтс Коллидж Замещенное соединение миноциклина, способ получения замещенных соединений миноциклина (варианты)
CZ2003343A3 (cs) * 2000-07-07 2003-05-14 Trustees Of Tufts College 7-Substituované tetracyklinové sloučeniny
US7094806B2 (en) * 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
HRP20030743A2 (en) * 2001-03-13 2005-06-30 Paratek Pharmaceuticals 7,9-substituted tetracycline compounds
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
AU2002250331A1 (en) * 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
EP1241160A1 (fr) * 2001-03-13 2002-09-18 Glaxo Group Limited Dérivés de tétracyclines et leur utilisation comme agents antibiotiques
US7045507B2 (en) 2001-03-14 2006-05-16 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as synergistic antifungal agents
JP2004530661A (ja) * 2001-03-14 2004-10-07 パラテック ファーマシューティカルズ インコーポレイテッド 抗真菌剤としての置換テトラサイクリン化合物
US8088820B2 (en) 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
ATE455092T1 (de) * 2001-04-24 2010-01-15 Paratek Pharm Innc Substituierte tetracyclin-verbindungen zur behandlung von malaria
EP2332549A1 (fr) 2001-07-13 2011-06-15 Paratek Pharmaceuticals, Inc. Nouvelle tetracyclines et leur utilisation en médicine
AU2002365120A1 (en) 2001-08-02 2003-07-15 Paratek Pharmaceuticals, Inc. Medicaments
US7056902B2 (en) * 2002-01-08 2006-06-06 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
EP2316450A1 (fr) * 2002-03-08 2011-05-04 Paratek Pharmaceuticals, Inc. Composés de tétracycline à substitution amino-méthyle
WO2003079983A2 (fr) * 2002-03-21 2003-10-02 Trustees Of Tufts College Procedes de preparation de tetracyclines substituees avec des compositions chimiques a base de metal de transition
KR101083498B1 (ko) * 2002-03-21 2011-11-16 파라테크 파마슈티컬스, 인크. 치환된 테트라시클린 화합물
CN1700922A (zh) * 2002-07-12 2005-11-23 帕拉特克药品公司 3、10或12a位取代的四环素化合物
US8173624B2 (en) * 2002-10-24 2012-05-08 Paratek Pharmaceuticals, Inc. Methods of using substituted tetracycline compounds to modulate RNA
JP2006503898A (ja) * 2002-10-24 2006-02-02 パラテック ファーマシューティカルズ， インク． マラリア治療のための置換テトラサイクリン化合物
US7230098B2 (en) 2003-02-26 2007-06-12 Sugen, Inc. Aminoheteroaryl compounds as protein kinase inhibitors
CN1845897A (zh) * 2003-07-09 2006-10-11 帕拉特克药品公司 取代的四环素化合物
EP2332904A3 (fr) 2004-01-15 2012-04-11 Paratek Pharmaceuticals, Inc. Derives des composes de tetracycline
AU2012202559B2 (en) * 2004-05-21 2014-07-17 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
BRPI0510113B1 (pt) 2004-05-21 2022-09-27 President And Fellows Of Harvard College Compostos de tetraciclinas e análogos das mesmas
TWI261038B (en) * 2004-08-11 2006-09-01 Bo-Cheng Chen Bicycle gear-shifting handgrip
EP2301916A3 (fr) 2004-10-25 2011-09-28 Paratek Pharmaceuticals, Inc. 4-aminotétracyclines et procédés d'utilisation associés
EP2284151A3 (fr) 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Composés de tétracycline substituée
EP1848685A1 (fr) 2005-02-04 2007-10-31 Paratek Pharmaceuticals, Inc. Derives 11a, 12 de composes de tetracycline
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
AR057034A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Metodos para purificar tigeciclina
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
AU2006331685A1 (en) * 2005-12-22 2007-07-05 Wyeth Methods of treating gastrointestinal tract infections with tigecycline
EP1965770A2 (fr) * 2005-12-22 2008-09-10 Wyeth a Corporation of the State of Delaware Formulations orales contenant de la tigecycline
WO2007087416A2 (fr) * 2006-01-24 2007-08-02 Paratek Pharaceuticals, Inc. Procede permettant d'accroitre la biodisponibilite orale de tetracyclines
EP2016044B1 (fr) 2006-04-07 2020-06-10 President and Fellows of Harvard College Dérivés de pentacycline pour le traitement d'infections
CA2652346A1 (fr) * 2006-05-15 2007-11-22 Paratek Pharmaceuticals, Inc. Methodes de regulation de l'expression de genes ou de produits geniques a l'aide de composes de tetracycline substituee
US7763735B2 (en) * 2006-10-11 2010-07-27 President And Fellows Of Harvard College Synthesis of enone intermediate
WO2008045507A2 (fr) 2006-10-11 2008-04-17 Paratek Pharmaceuticals, Inc. Composés de tétracycline substitués utilisés pour le traitement d'infections à bacillus anthracis
US8513223B2 (en) 2006-12-21 2013-08-20 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of inflammatory skin disorders
ES2463457T3 (es) * 2006-12-21 2014-05-28 Paratek Pharmaceuticals, Inc. Derivados de la tetraciclina para el tratamiento de infecciones bacterianas, virales y parasitarias
JP2010523684A (ja) * 2007-04-12 2010-07-15 パラテック ファーマシューティカルズ インコーポレイテッド テトラサイクリン化合物を用いる、脊髄筋委縮症を治療するための方法
JP2010525069A (ja) * 2007-04-27 2010-07-22 パラテック ファーマシューティカルズ インコーポレイテッド アミノアルキルテトラサイクリン化合物の合成方法および精製方法
US9522872B2 (en) 2007-07-06 2016-12-20 Paratek Pharmaceuticals, Inc. Methods for synthesizing substituted tetracycline compounds
CA2717703A1 (fr) 2008-03-05 2009-09-11 Paratek Pharmaceuticals, Inc. Composes de minocycline et procedes d'utilisation de ceux-ci
US20100022483A1 (en) * 2008-04-14 2010-01-28 Paratek Pharmaceuticals, Inc. Substituted Tetracycline Compounds
TW202216656A (zh) * 2008-05-19 2022-05-01 美商Ｐｒｔｋ Ｓｐｖ２公司 四環素化合物之甲苯磺酸鹽及同素異形體
BRPI0918050A2 (pt) * 2008-09-19 2015-09-22 Paratek Pharm Innc compostos de tetraciclina para o tratamento de artrite reumatoide e metodos relacionados de tratamento
WO2010126607A2 (fr) 2009-04-30 2010-11-04 President And Fellows Of Harvard College Synthèse de tétracyclines et intermédiaires de celles-ci
US9315451B2 (en) 2009-05-08 2016-04-19 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
DK2470500T3 (en) 2009-08-28 2018-01-08 Tetraphase Pharmaceuticals Inc tetracycline
WO2013142669A1 (fr) * 2012-03-21 2013-09-26 Case Western Reserve University Procédé de modulation de la ribonucléotide réductase
CN108329312B (zh) 2012-08-31 2021-12-31 四相制药公司 四环素化合物
AU2015301891B2 (en) 2014-08-11 2019-12-05 Angion Biomedica Corporation Cytochrome P450 inhibitors and uses thereof
EP3240778A4 (fr) 2014-12-31 2018-07-11 Angion Biomedica Corp. Méthodes et agents pour traiter une maladie
HUE066360T2 (hu) 2016-10-19 2024-07-28 Tetraphase Pharmaceuticals Inc Eravaciklin kristályformái
RU2019113715A (ru) 2016-11-01 2020-12-03 Паратек Фармасьютикалс, Инк. 9-аминометилминоциклиновые соединения и их применение для лечениия внебольничной бактериальной пневмонии(вбп)
CN113717073B (zh) * 2021-08-26 2023-11-14 河北圣雪大成制药有限责任公司 一种合成盐酸米诺环素的新方法

Family Cites Families (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE26271E (en) 1967-09-26 Reductive alkylation process
US2990331A (en) 1956-11-23 1961-06-27 Pfizer & Co C Stable solutions of salts of tetracyclines for parenteral administration
US2980584A (en) 1957-10-29 1961-04-18 Pfizer & Co C Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation
US3062717A (en) 1958-12-11 1962-11-06 Pfizer & Co C Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation
US3338963A (en) * 1960-10-28 1967-08-29 American Cyanamid Co Tetracycline compounds
US3219671A (en) 1961-04-14 1965-11-23 American Cyanamid Co Substituted 6-deoxytetracyclines and 6-demethyl-6-deoxytetracyclines
US3165531A (en) 1962-03-08 1965-01-12 Pfizer & Co C 13-substituted-6-deoxytetracyclines and process utilizing the same
US3148212A (en) * 1961-12-22 1964-09-08 American Cyanamid Co Reductive alkylation process
USRE26253E (en) 1963-05-17 1967-08-15 And z-alkylamino-g-deoxytetracycline
NL6408922A (fr) 1963-08-08 1965-02-09
US3338983A (en) * 1964-01-24 1967-08-29 Exxon Research Engineering Co Purification of alkyl aryl hydrocarbons
US3609188A (en) 1964-10-29 1971-09-28 American Cyanamid Co 4-dedimethylamino-4-substituted-amino-6-demethyltetracyclines
US3345379A (en) * 1965-02-26 1967-10-03 American Cyanamid Co 7-imidomethyl-6-demethyl-6-deoxytetracyclines
US3454697A (en) 1965-06-08 1969-07-08 American Cyanamid Co Tetracycline antibiotic compositions for oral use
US3350557A (en) 1965-06-09 1967-10-31 Szymanski Ronald Fog lens attachments for vehicle headlights
US3397230A (en) 1966-03-14 1968-08-13 American Cyanamid Co Nitration of tetracyclines
US3433834A (en) 1966-03-14 1969-03-18 American Cyanamid Co Nitration of 11a-chloro tetracyclines
US3341585A (en) 1966-05-06 1967-09-12 American Cyanamid Co Substituted 7-and/or 9-amino-6-deoxytetracyclines
NL6607516A (fr) 1966-05-31 1967-12-01
US3345410A (en) 1966-12-01 1967-10-03 American Cyanamid Co Substituted 7- and/or 9-amino tetracyclines
US3403179A (en) 1967-01-10 1968-09-24 American Cyanamid Co Novel 7-(1, 2-bis-substituted-hydrazino)-tetracyclines and methods of preparing same
US3483251A (en) 1967-03-03 1969-12-09 American Cyanamid Co Reductive alkylation process
US3373196A (en) 1967-03-21 1968-03-12 American Cyanamid Co 7-and/or 9-(lower alkyl) amino-5a, 6-anhydrotetracyclines
US3360561A (en) 1967-06-19 1967-12-26 American Cyanamid Co Nitration of tetracyclines
US3518306A (en) * 1968-02-19 1970-06-30 American Cyanamid Co 7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines
US3579579A (en) * 1968-04-18 1971-05-18 American Cyanamid Co Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines
DE1767891C3 (de) 1968-06-28 1980-10-30 Pfizer Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat
NL158172B (nl) 1972-09-18 1978-10-16 Farmaceutici Italia Werkwijze voor het bereiden van tetracyclinederivaten met een substituent op de 7-plaats.
US3957980A (en) 1972-10-26 1976-05-18 Pfizer Inc. Doxycycline parenteral compositions
DE2527568A1 (de) * 1974-06-25 1976-01-15 Farmaceutici Italia Verfahren zur herstellung von alkyltetracyclinen und neue tetracyclinderivate
DE2437487A1 (de) 1974-08-03 1976-02-19 Merck Patent Gmbh 7-methoxy-6-thia-tetracycline und verfahren zu ihrer herstellung
DE2442829A1 (de) 1974-09-06 1976-03-18 Merck Patent Gmbh Tetracyclische verbindungen und verfahren zu ihrer herstellung
US4018889A (en) 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions
US4126680A (en) 1977-04-27 1978-11-21 Pfizer Inc. Tetracycline antibiotic compositions
JPH0737433B2 (ja) * 1987-06-11 1995-04-26 協和醗酵工業株式会社 ７−アミノ−６−デメチル−６−デオキシテトラサイクリンの製造法
JPS6429346A (en) * 1987-07-24 1989-01-31 Nippon Kayaku Kk Production of 7-nitro-6-demethyl-6-deoxytetracycline
US5494903A (en) 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5281628A (en) 1991-10-04 1994-01-25 American Cyanamid Company 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines
US5442059A (en) 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5248797A (en) 1992-08-13 1993-09-28 American Cyanamid Company Method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5328902A (en) 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5420272A (en) 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5284963A (en) 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
SG47520A1 (en) 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
JPH06256280A (ja) 1992-11-17 1994-09-13 Univ New York State 糖尿病における過度のコラーゲン架橋結合を阻害する非抗菌性化学修飾テトラサイクリンを含むテトラサイクリン
US5371076A (en) 1993-04-02 1994-12-06 American Cyanamid Company 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
WO1995022529A1 (fr) 1994-02-17 1995-08-24 Pfizer Inc. Derives de 9-(amino-substitues)-alpha-6-deoxy-5-oxy tetracycline, leur preparation et leur utilisation comme antibiotiques
US5675030A (en) 1994-11-16 1997-10-07 American Cyanamid Company Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound
US5567693A (en) 1994-12-13 1996-10-22 American Cyanamid Company Method for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth
US5843925A (en) 1994-12-13 1998-12-01 American Cyanamid Company Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth
EP0823893A1 (fr) 1995-05-03 1998-02-18 Pfizer Inc. Nouveaux derives de tetracycline
US5789395A (en) 1996-08-30 1998-08-04 The Research Foundation Of State University Of New York Method of using tetracycline compounds for inhibition of endogenous nitric oxide production
WO1999037306A1 (fr) 1998-01-23 1999-07-29 Trustees Of Tufts College Composes pharmaceutiquement actifs et procedes d'utilisation correspondants
US6506740B1 (en) 1998-11-18 2003-01-14 Robert A. Ashley 4-dedimethylaminotetracycline derivatives
DE69932846T2 (de) * 1998-11-18 2007-03-15 Collagenex Pharmaceuticals, Inc. Neue 4-dedimethylaminotetracyclinderivate
US6946453B2 (en) 1998-11-18 2005-09-20 Collagenex Pharmaceuticals, Inc. 4-dedimethylaminotracycline derivatives
CA2382202A1 (fr) 1999-08-26 2001-03-01 Sydney Brenner Conjugues de medicaments et leurs procedes de preparation
US8106225B2 (en) 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
EP1666454B1 (fr) 1999-09-14 2011-09-07 Trustees Of Tufts College Techniques de preparation de tetracyclines substituees avec des solutions chimiques a base de metal de transition
EP1263442A1 (fr) 2000-01-24 2002-12-11 Trustees Of Tufts College COMPOSES DE TETRACYCLINE POUR LE TRAITEMENT DE TROUBLES AFFERENTS AU i CRYPTOSPORIDIUM PARVUM /i
DE60129116T2 (de) 2000-03-31 2008-03-13 Trustees Of Tufts College, Medford 7- und 9-carbamat, harnstoff, thioharnstoff, thiocarbamat und heteroaryl-amino substituierte tetracyclinverbindungen
ATE264295T1 (de) 2000-05-15 2004-04-15 Paratek Pharm Innc 7-substituierte kondensierte ring-tetrazyclin- verbindungen
US20040224927A1 (en) 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
US20020132798A1 (en) 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
WO2001098259A1 (fr) 2000-06-16 2001-12-27 Trustees Of Tufts College Composes de tetracycline 7-phenyl-substituee
AU2001268475A1 (en) 2000-06-16 2002-01-02 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
US20020128237A1 (en) 2000-06-16 2002-09-12 Nelson Mark L. 7-N-substituted phenyl tetracycline compounds
EP1303479B1 (fr) * 2000-07-07 2011-04-06 Trustees Of Tufts College Composes de tetracycline substitues en 7, 8 et 9
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
US20050143353A1 (en) 2000-07-07 2005-06-30 Paratek Pharmaceuticals, Inc. 13-Substituted methacycline compounds
CZ2003343A3 (cs) 2000-07-07 2003-05-14 Trustees Of Tufts College 7-Substituované tetracyklinové sloučeniny
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
HRP20030743A2 (en) 2001-03-13 2005-06-30 Paratek Pharmaceuticals 7,9-substituted tetracycline compounds
AU2002250331A1 (en) 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
JP2004530661A (ja) * 2001-03-14 2004-10-07 パラテック ファーマシューティカルズ インコーポレイテッド 抗真菌剤としての置換テトラサイクリン化合物
US7045507B2 (en) 2001-03-14 2006-05-16 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as synergistic antifungal agents
US8088820B2 (en) 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
US20060194773A1 (en) 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
AU2002365120A1 (en) 2001-08-02 2003-07-15 Paratek Pharmaceuticals, Inc. Medicaments
KR100816340B1 (ko) 2001-08-27 2008-03-24 삼성전자주식회사 액정 표시 장치 제조용 노광 마스크와 이를 이용한 액정표시 장치 제조에서의 기판의 노광 방법
US7056902B2 (en) 2002-01-08 2006-06-06 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
EP2316450A1 (fr) 2002-03-08 2011-05-04 Paratek Pharmaceuticals, Inc. Composés de tétracycline à substitution amino-méthyle
KR101083498B1 (ko) 2002-03-21 2011-11-16 파라테크 파마슈티컬스, 인크. 치환된 테트라시클린 화합물
CN1700922A (zh) 2002-07-12 2005-11-23 帕拉特克药品公司 3、10或12a位取代的四环素化合物
US8173624B2 (en) 2002-10-24 2012-05-08 Paratek Pharmaceuticals, Inc. Methods of using substituted tetracycline compounds to modulate RNA
CN1845897A (zh) 2003-07-09 2006-10-11 帕拉特克药品公司 取代的四环素化合物
US20060287283A1 (en) 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
EP2332904A3 (fr) 2004-01-15 2012-04-11 Paratek Pharmaceuticals, Inc. Derives des composes de tetracycline
EP2301916A3 (fr) 2004-10-25 2011-09-28 Paratek Pharmaceuticals, Inc. 4-aminotétracyclines et procédés d'utilisation associés
EP2284151A3 (fr) 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Composés de tétracycline substituée
EP1848685A1 (fr) * 2005-02-04 2007-10-31 Paratek Pharmaceuticals, Inc. Derives 11a, 12 de composes de tetracycline
CA2652346A1 (fr) * 2006-05-15 2007-11-22 Paratek Pharmaceuticals, Inc. Methodes de regulation de l'expression de genes ou de produits geniques a l'aide de composes de tetracycline substituee
JP2010523684A (ja) * 2007-04-12 2010-07-15 パラテック ファーマシューティカルズ インコーポレイテッド テトラサイクリン化合物を用いる、脊髄筋委縮症を治療するための方法

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US20030055025A1 (en) 2003-03-20
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