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EP3240778A4 - Méthodes et agents pour traiter une maladie - Google Patents

Méthodes et agents pour traiter une maladie Download PDF

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Publication number
EP3240778A4
EP3240778A4 EP15876137.9A EP15876137A EP3240778A4 EP 3240778 A4 EP3240778 A4 EP 3240778A4 EP 15876137 A EP15876137 A EP 15876137A EP 3240778 A4 EP3240778 A4 EP 3240778A4
Authority
EP
European Patent Office
Prior art keywords
agents
methods
treating disease
disease
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP15876137.9A
Other languages
German (de)
English (en)
Other versions
EP3240778A1 (fr
Inventor
Bijoy Panicker
Lambertus J. W. M. OEHLEN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elicio Therapeutics Inc
Original Assignee
Angion Biomedica Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angion Biomedica Corp filed Critical Angion Biomedica Corp
Publication of EP3240778A1 publication Critical patent/EP3240778A1/fr
Publication of EP3240778A4 publication Critical patent/EP3240778A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/427Thiazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/04Drugs for disorders of the respiratory system for throat disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/40Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Addiction (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP15876137.9A 2014-12-31 2015-12-29 Méthodes et agents pour traiter une maladie Withdrawn EP3240778A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462099120P 2014-12-31 2014-12-31
PCT/US2015/067801 WO2016109492A1 (fr) 2014-12-31 2015-12-29 Méthodes et agents pour traiter une maladie

Publications (2)

Publication Number Publication Date
EP3240778A1 EP3240778A1 (fr) 2017-11-08
EP3240778A4 true EP3240778A4 (fr) 2018-07-11

Family

ID=56284982

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15876137.9A Withdrawn EP3240778A4 (fr) 2014-12-31 2015-12-29 Méthodes et agents pour traiter une maladie

Country Status (8)

Country Link
US (3) US10287282B2 (fr)
EP (1) EP3240778A4 (fr)
JP (2) JP2018501279A (fr)
CN (1) CN107531631B (fr)
AU (2) AU2015374231B2 (fr)
CA (1) CA2970819A1 (fr)
IL (2) IL252904B (fr)
WO (1) WO2016109492A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10414760B2 (en) 2016-11-29 2019-09-17 Angion Biomedica Corp. Cytochrome P450 inhibitors and uses thereof
CA2957785C (fr) 2014-08-11 2023-01-03 Angion Biomedica Corporation Inhibiteurs de cytochrome p450 et leurs utilisations
WO2016109492A1 (fr) 2014-12-31 2016-07-07 Angion Biomedica Corp Méthodes et agents pour traiter une maladie
CN108754141B (zh) * 2018-08-22 2020-12-08 中国科学院上海有机化学研究所 一种萃取有机相及其应用
US12285182B2 (en) 2018-10-10 2025-04-29 Innova Vascular, Inc. Devices and methods for removing an embolus

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4631862B1 (fr) * 1968-10-05 1971-09-17
US20020045615A1 (en) * 2000-06-21 2002-04-18 Alexander Alanine Benzothiazole derivatives with activity as adenosine receptor ligands
US20030166668A1 (en) * 2001-11-15 2003-09-04 The Institutes For Pharmaceutical Discovery, Inc. A Corporation Of The State Of Delaware Substituted heteroarylalkanoic acids
US20130196967A1 (en) * 2012-01-31 2013-08-01 Alessandra Bartolozzi Heterocyclic compounds as inhibitors of leukotriene production
WO2013181104A2 (fr) * 2012-06-01 2013-12-05 The Board Of Trustees Of The Univesity Of Arkansas Alkylation d'azoles
US20140018401A1 (en) * 2010-06-01 2014-01-16 Angion Biomedica Corp Cytochrome p450 inhibitors and uses thereof

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2124211B (en) 1982-06-25 1985-12-24 Zyma Sa Dithio compounds pharmaceutical preparations containing them and their use
GB8713861D0 (en) 1987-06-13 1987-07-15 Beecham Group Plc Compounds
US5308854A (en) 1990-06-18 1994-05-03 Merck & Co., Inc. Inhibitors of HIV reverse transcriptase
EP0472053B1 (fr) 1990-08-20 1998-06-17 Eisai Co., Ltd. Dérivés de sulfonamide
TW210334B (fr) 1990-12-12 1993-08-01 Ciba Geigy Ag
DE4126277A1 (de) 1991-08-08 1993-02-11 Cassella Ag Hydantoinderivate
JPH0616638A (ja) 1992-03-30 1994-01-25 Yoshitomi Pharmaceut Ind Ltd ピリジン化合物およびその医薬用途
US5616537A (en) 1992-07-03 1997-04-01 Kumiai Chemical Industry Co., Ltd. Condensed heterocyclic derivatives and herbicides
EP0639573A1 (fr) 1993-08-03 1995-02-22 Hoechst Aktiengesellschaft Hétérocycles à cinq chaînons benzocondensés, procédé pour leur préparation, leur utilisation comme médicament et comme diagnostique aussi bien que les produits pharmaceutiques le contenant
FR2716192B1 (fr) 1994-02-17 1996-04-12 Rhone Poulenc Agrochimie Dérivés de 2-imidazoline-5-ones fongicides.
US5891916A (en) 1995-06-21 1999-04-06 Takeda Chemical Industries, Ltd. Aromatic hydroxamix acid compounds, their production and use
US5977101A (en) 1995-06-29 1999-11-02 Smithkline Beecham Corporation Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity
US5576349A (en) 1995-11-30 1996-11-19 The General Hospital Corporation Retionoic acid treatment of cardiac arrhythmia
DE19610932A1 (de) 1996-03-20 1997-09-25 Bayer Ag 2-Aryl-substituierte Pyridine
DE69717627T2 (de) 1996-06-27 2003-09-18 Janssen Pharmaceutica N.V., Beerse N-4-(heteroarylmethyl)phenyl-heteroarylaminderivate
JPH1017549A (ja) 1996-07-02 1998-01-20 Banyu Pharmaceut Co Ltd 二環性芳香族アミジン誘導体
AR008789A1 (es) 1996-07-31 2000-02-23 Bayer Corp Piridinas y bifenilos substituidos
US6020339A (en) 1997-10-03 2000-02-01 Merck & Co., Inc. Aryl furan derivatives as PDE IV inhibitors
US20080300281A1 (en) 1997-12-22 2008-12-04 Jacques Dumas Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas
DK1047418T3 (da) 1997-12-22 2005-11-21 Bayer Pharmaceuticals Corp Inhibering af raf-kinase ved hjælp af substituerede heterocykliske urinstoffer
US20070244120A1 (en) 2000-08-18 2007-10-18 Jacques Dumas Inhibition of raf kinase using substituted heterocyclic ureas
US20120046290A1 (en) 1997-12-22 2012-02-23 Jacques Dumas Inhibition of p38 kinase activity using substituted heterocyclic ureas
AU2006201959B2 (en) 1997-12-22 2008-09-04 Bayer Healthcare Llc Inhibition of Raf Kinase using Substituted Heterocyclic Ureas
US7329670B1 (en) 1997-12-22 2008-02-12 Bayer Pharmaceuticals Corporation Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
CA2315720A1 (fr) 1997-12-22 1999-07-01 Bayer Corporation Inhibition de l'activite de p38 kinase au moyen d'urees heterocycliques substituees
WO1999059586A1 (fr) 1998-05-19 1999-11-25 Regents Of The University Of California Derives de thiazolidine et d'oxazolidine pour le traitement d'infarctus du myocarde aigus et pour l'inhibition de l'apoptose des cardiomyocytes
BR0112265A (pt) 2000-07-07 2003-06-24 Tufts College Compostos de tetraciclina substituìda, e de sanciclina 7-substituìda, método para tratar um estado responsivo à tetraciclina em um indivìduo, e, composição farmacêutica
AU2001271265B2 (en) 2000-07-11 2005-01-06 University Of Maryland, Baltimore Novel c-4 substituted retinoids
EP1318995B1 (fr) 2000-09-19 2006-03-08 Centre National De La Recherche Scientifique (Cnrs) Derives de pyridinone et de pyridinethione presentant des proprietes inhibitrices du vih
WO2002051821A1 (fr) 2000-12-22 2002-07-04 Astrazeneca Ab Composes therapeutiques
US8124625B2 (en) 2001-09-14 2012-02-28 Shionogi & Co., Ltd. Method of enhancing the expression of apolipoprotein AI using olefin derivatives
TW200303201A (en) 2001-12-10 2003-09-01 Bristol Myers Squibb Co Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
US20030199523A1 (en) 2002-02-28 2003-10-23 Snutch Terrance P. Heterocyclic calcium in channel blockers
US7282591B2 (en) 2002-04-11 2007-10-16 Merck & Co., Inc. 1h-benzo{f}indazol-5-yl derivatives as selective glucocorticoid receptor modulators
MXPA05007857A (es) 2003-01-22 2005-10-18 Lilly Co Eli Moduladores derivados de indol de receptores nucleares de hormonas esteroideas.
GB0314733D0 (en) 2003-06-24 2003-07-30 Glaxo Group Ltd Medicaments
RU2363696C2 (ru) 2003-07-10 2009-08-10 Оси Фармасьютикалз, Инк. Производные нафтилена как ингибиторы цитохрома р450
TW200600494A (en) 2004-03-08 2006-01-01 Chugai Pharmaceutical Co Ltd Bisphenyl compounds useful as vitamin d3 receptor agonists
US7262318B2 (en) 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
WO2005105814A1 (fr) * 2004-04-28 2005-11-10 Incyte Corporation Inhibiteurs tetracycliques de janus kinases
US20050288340A1 (en) 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
US7662844B2 (en) 2004-07-12 2010-02-16 Osi Pharmaceuticals, Inc. Naphthylene derivatives as cytochrome P450 inhibitors
KR20060087386A (ko) 2005-01-28 2006-08-02 주식회사 대웅제약 신규 벤조이미다졸 유도체 및 이를 함유하는 약제학적조성물
US7579348B2 (en) 2005-02-25 2009-08-25 Pgxhealth, Llc Derivatives of 8-substituted xanthines
AR056339A1 (es) 2005-05-09 2007-10-03 Astrazeneca Ab Derivados benzoicos
DOP2006000273A (es) 2005-12-08 2007-10-15 Aventis Pharma Inc Uso de un antagonista de cb1 para tratar efectos secundarios y sintomas negativos de la esquizofrenia
JP2009525955A (ja) 2006-01-13 2009-07-16 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼ阻害剤
WO2007091140A1 (fr) 2006-02-06 2007-08-16 Pfizer Products Inc. Composés substitués de phénylsulfamoyle agonistes du ppar
CN101041660B (zh) 2006-03-22 2010-05-12 中国科学院化学研究所 1,2-二氢吡啶衍生物、碳苷中间体及其制备方法与应用
ES2465666T3 (es) 2006-03-30 2014-06-06 Janssen R&D Ireland Pirimidinas 5-amido-sustituidas inhibidoras del HIV
WO2008017827A2 (fr) 2006-08-08 2008-02-14 Argenta Discovery Limited Composés chimiques
ES2393132T3 (es) 2006-10-23 2012-12-18 Sgx Pharmaceuticals, Inc. Moduoladores de proteína quinasa de triazolopiridazina
WO2008082003A1 (fr) 2006-12-29 2008-07-10 Takeda Pharmaceutical Company Limited Composes heterocycliques lies par fusion developpant une activite antagoniste au crf
JP4631862B2 (ja) * 2007-03-06 2011-02-16 船井電機株式会社 受信装置
JP5561702B2 (ja) 2007-08-02 2014-07-30 アムジエン・インコーポレーテツド Pi3キナーゼ調節剤および使用方法
RU2010125220A (ru) 2007-11-20 2011-12-27 Мерк Шарп Энд Домэ Корп. (Us) Ненуклеозидные ингибиторы обратной транскриптазы
WO2009081246A2 (fr) 2007-12-19 2009-07-02 Pfizer Inc. Diamines bicycliques en tant qu'agonistes de récepteur nicotinique
JP5369854B2 (ja) 2008-04-21 2013-12-18 住友化学株式会社 有害節足動物防除組成物および縮合複素環化合物
US9156792B2 (en) 2008-05-09 2015-10-13 University Of Maryland, Baltimore Retinamide and uses thereof
GB0811091D0 (en) 2008-06-17 2008-07-23 Cancer Rec Tech Ltd CYP26 Inhibitors
AR072297A1 (es) 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
AR073010A1 (es) 2008-08-12 2010-10-06 Takeda Pharmaceutical Compuesto amida con actividad agonista del gpr52
MX2011006332A (es) 2008-12-23 2011-06-27 Abbott Lab Compuestos antivirales.
EP2519508B1 (fr) 2009-12-31 2014-07-02 Viamet Pharmaceuticals, Inc. Composés inhibiteurs de métallo-enzyme
CN102153547A (zh) 2010-02-11 2011-08-17 山东轩竹医药科技有限公司 含有并环的噁唑烷酮抗菌素
GB201004739D0 (en) 2010-03-22 2010-05-05 Prosidion Ltd Receptor modulators
JP2013522376A (ja) 2010-03-24 2013-06-13 メディカル ユニバーシティー オブ サウス カロライナ 変性疾患を治療するための組成物および方法
CN102206172B (zh) 2010-03-30 2015-02-25 中国医学科学院医药生物技术研究所 一组取代双芳基化合物及其制备方法和抗病毒应用
US20210171515A1 (en) 2010-06-01 2021-06-10 Angion Biomedica Corp. Cytochrome p450 inhibitors and uses thereof
US10414760B2 (en) 2016-11-29 2019-09-17 Angion Biomedica Corp. Cytochrome P450 inhibitors and uses thereof
WO2012036287A1 (fr) 2010-09-17 2012-03-22 国立大学法人大阪大学 Nouvel analogue de cortistatine a et son utilisation
DK2651915T3 (en) 2010-12-17 2016-07-18 Mitsubishi Tanabe Pharma Corp Continuous arycyclic compound
EP2668177B1 (fr) 2011-01-28 2014-10-22 Boehringer Ingelheim International GmbH Pyridinyl-pyrimidines substituées et leur utilisation en tant que médicaments
JP5881624B2 (ja) 2011-02-18 2016-03-09 信一郎 礒部 蛍光色素
US8218718B1 (en) 2011-06-01 2012-07-10 Elekta Ab (Publ) Radiotherapy and imaging methods and apparatus
EP2736330A4 (fr) 2011-07-29 2015-05-27 Tempero Pharmaceuticals Inc Composés et méthodes
EP2736332A4 (fr) 2011-07-29 2015-03-18 Tempero Pharmaceuticals Inc Composés et méthodes
TW201317229A (zh) 2011-09-14 2013-05-01 Daiichi Sankyo Co Ltd 稠合雜環衍生物
US20140235667A1 (en) 2011-09-22 2014-08-21 Merck Sharp & Dohme Corp. Imidazopyridyl compounds as aldosterone synthase inhibitors
US9278093B2 (en) 2012-04-04 2016-03-08 Merck Sharp & Dohme Corp. Aldosterone synthase inhibitors
JP5977349B2 (ja) 2012-06-15 2016-08-24 田辺三菱製薬株式会社 芳香族複素環化合物
US20160038490A1 (en) 2012-07-18 2016-02-11 Angion Biomedica Corp. Compositions and methods for treating dysproliferative diseases
CA2886117C (fr) 2012-10-05 2022-05-31 Merck Sharp & Dohme Corp. Composes d'indoline utilises comme inhibiteurs de l'aldosterone synthase
US9309222B2 (en) 2012-10-16 2016-04-12 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
ME02794B (fr) 2012-10-16 2018-01-20 Janssen Pharmaceutica Nv Modulateurs de ror-gamma-t de type quinolinyle à liaison méthylène
JP6250686B2 (ja) 2012-10-16 2017-12-20 ヤンセン ファーマシューティカ エヌ.ベー. Rorγtのヘテロアリール結合させたキノリニルモジュレータ
WO2014093960A1 (fr) 2012-12-16 2014-06-19 Angion Biomedica Corp. Compositions et méthodes de traitement de maladie
CA2957785C (fr) 2014-08-11 2023-01-03 Angion Biomedica Corporation Inhibiteurs de cytochrome p450 et leurs utilisations
WO2016109492A1 (fr) 2014-12-31 2016-07-07 Angion Biomedica Corp Méthodes et agents pour traiter une maladie

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4631862B1 (fr) * 1968-10-05 1971-09-17
US20020045615A1 (en) * 2000-06-21 2002-04-18 Alexander Alanine Benzothiazole derivatives with activity as adenosine receptor ligands
US20030166668A1 (en) * 2001-11-15 2003-09-04 The Institutes For Pharmaceutical Discovery, Inc. A Corporation Of The State Of Delaware Substituted heteroarylalkanoic acids
US20140018401A1 (en) * 2010-06-01 2014-01-16 Angion Biomedica Corp Cytochrome p450 inhibitors and uses thereof
US20130196967A1 (en) * 2012-01-31 2013-08-01 Alessandra Bartolozzi Heterocyclic compounds as inhibitors of leukotriene production
WO2013181104A2 (fr) * 2012-06-01 2013-12-05 The Board Of Trustees Of The Univesity Of Arkansas Alkylation d'azoles

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2016109492A1 *

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AU2020257075A1 (en) 2020-11-19
JP2021035975A (ja) 2021-03-04
IL252904B (en) 2021-04-29
CA2970819A1 (fr) 2016-07-07
US20210323955A1 (en) 2021-10-21
AU2015374231A1 (en) 2017-07-06
WO2016109492A1 (fr) 2016-07-07
CN107531631A (zh) 2018-01-02
US20180002324A1 (en) 2018-01-04
JP2018501279A (ja) 2018-01-18
JP7140813B2 (ja) 2022-09-21
IL252904A0 (en) 2017-08-31
AU2015374231B2 (en) 2020-07-23
EP3240778A1 (fr) 2017-11-08
CN107531631B (zh) 2021-09-03
US10287282B2 (en) 2019-05-14
AU2020257075B2 (en) 2022-06-16
US10851095B2 (en) 2020-12-01
US11434234B2 (en) 2022-09-06
US20190256507A1 (en) 2019-08-22

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