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ZA200202947B - Methods of asymmetrically synthesizing enantiomers of casodex, its derivatives and intermediates thereof. - Google Patents

Methods of asymmetrically synthesizing enantiomers of casodex, its derivatives and intermediates thereof.

Info

Publication number
ZA200202947B
ZA200202947B ZA200202947A ZA200202947A ZA200202947B ZA 200202947 B ZA200202947 B ZA 200202947B ZA 200202947 A ZA200202947 A ZA 200202947A ZA 200202947 A ZA200202947 A ZA 200202947A ZA 200202947 B ZA200202947 B ZA 200202947B
Authority
ZA
South Africa
Prior art keywords
casodex
intermediates
derivatives
methods
asymmetrically synthesizing
Prior art date
Application number
ZA200202947A
Other languages
English (en)
Inventor
Nnochiri Ekwuribe
Original Assignee
Nobex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nobex Corp filed Critical Nobex Corp
Publication of ZA200202947B publication Critical patent/ZA200202947B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D317/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
ZA200202947A 1999-10-19 2002-04-15 Methods of asymmetrically synthesizing enantiomers of casodex, its derivatives and intermediates thereof. ZA200202947B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16041299P 1999-10-19 1999-10-19

Publications (1)

Publication Number Publication Date
ZA200202947B true ZA200202947B (en) 2003-09-23

Family

ID=22576803

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200202947A ZA200202947B (en) 1999-10-19 2002-04-15 Methods of asymmetrically synthesizing enantiomers of casodex, its derivatives and intermediates thereof.

Country Status (18)

Country Link
US (2) US6583306B1 (xx)
EP (1) EP1222165A2 (xx)
JP (1) JP5112583B2 (xx)
KR (1) KR20020091047A (xx)
CN (1) CN1409702A (xx)
AU (1) AU1968601A (xx)
BR (1) BR0014889A (xx)
CA (1) CA2387570A1 (xx)
CZ (1) CZ20021340A3 (xx)
HK (1) HK1048298A1 (xx)
HU (1) HUP0203785A2 (xx)
IL (2) IL149056A0 (xx)
MX (1) MXPA02003884A (xx)
NO (1) NO20021831L (xx)
NZ (1) NZ518392A (xx)
PL (1) PL354620A1 (xx)
WO (1) WO2001028990A2 (xx)
ZA (1) ZA200202947B (xx)

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US6071957A (en) 1996-11-27 2000-06-06 The University Of Tennessee Research Corporation Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer
US8445534B2 (en) 2000-08-24 2013-05-21 University Of Tennessee Research Foundation Treating androgen decline in aging male (ADAM)-associated conditions with SARMs
US6838484B2 (en) 2000-08-24 2005-01-04 University Of Tennessee Research Foundation Formulations comprising selective androgen receptor modulators
US8008348B2 (en) 2001-12-06 2011-08-30 University Of Tennessee Research Foundation Treating muscle wasting with selective androgen receptor modulators
US6998500B2 (en) 2000-08-24 2006-02-14 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US7026500B2 (en) 2000-08-24 2006-04-11 University Of Tennessee Research Foundation Halogenated selective androgen receptor modulators and methods of use thereof
US7622503B2 (en) 2000-08-24 2009-11-24 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US6737550B2 (en) * 2001-06-13 2004-05-18 Biogal Gryogyszergyar Rt. Process for preparing rac-bicalutamide and its intermediates
US8853266B2 (en) 2001-12-06 2014-10-07 University Of Tennessee Research Foundation Selective androgen receptor modulators for treating diabetes
IL162340A0 (en) 2001-12-06 2005-11-20 Gtx Inc Treating muscle wasting with selective androgen receptor modulators
JP4255381B2 (ja) 2001-12-13 2009-04-15 住友化学株式会社 ビカルタミドの結晶およびその製造方法
DK1480634T3 (da) 2002-02-07 2011-11-14 Univ Tennessee Res Foundation Selektive androgenreceptormodulatorer (SARM) til behandling af benign prostatahyperplasi
ATE533494T1 (de) 2002-02-28 2011-12-15 Univ Tennessee Res Foundation Mehrfach substituierte selektive androgen- rezeptor-modulatoren und anwendungsverfahren dafür
WO2003074450A2 (en) 2002-02-28 2003-09-12 The University Of Tennessee Research Corporation Radiolabeled selective androgen receptor modulators and their use in prostate cancer imaging and therapy
US7803970B2 (en) 2002-02-28 2010-09-28 University Of Tennessee Research Foundation Multi-substitued selective androgen receptor modulators and methods of use thereof
US7772433B2 (en) 2002-02-28 2010-08-10 University Of Tennessee Research Foundation SARMS and method of use thereof
DE10222104A1 (de) 2002-05-17 2003-12-04 Helm Ag Verfahren zur Herstellung von N-(4'-Cyano-3'-trifluormethyl)-3-(4"-fluorphenylsulfonyl)-2-hydroxy-2-methylpropionamid
US7741371B2 (en) 2002-06-17 2010-06-22 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
CN100537520C (zh) 2002-06-17 2009-09-09 田纳西大学研究基金会 N-桥连选择性雄激素受体调节剂及其使用方法
EP1402924B1 (de) * 2002-09-04 2008-12-31 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verwendung eines Mittel zur Therapie der Herzhypertrophie
US20040063782A1 (en) * 2002-09-27 2004-04-01 Westheim Raymond J.H. Bicalutamide forms
US6818766B2 (en) * 2002-10-02 2004-11-16 Synthon Bv Process for making bicalutamide and intermediates thereof
AU2003287077B2 (en) 2002-10-15 2007-09-20 University Of Tennessee Research Foundation Methylene-bridged selective androgen receptor modulators and methods of use thereof
US8309603B2 (en) 2004-06-07 2012-11-13 University Of Tennessee Research Foundation SARMs and method of use thereof
JP4322621B2 (ja) 2003-10-16 2009-09-02 住友化学株式会社 ４’−シアノ−３−［（４−フルオロフェニル）スルホニル］−２−ヒドロキシ−２−メチル−３’−トリフルオロメチルプロピオンアニリドの製造方法
EP1631540A4 (en) 2003-12-16 2006-10-04 Gtx Inc PRODRUGS OF SELECTIVE ANDROGEN RECEPTOR MODULATORS AND METHOD OF USE THEREOF
US9884038B2 (en) 2004-06-07 2018-02-06 University Of Tennessee Research Foundation Selective androgen receptor modulator and methods of use thereof
US9889110B2 (en) 2004-06-07 2018-02-13 University Of Tennessee Research Foundation Selective androgen receptor modulator for treating hormone-related conditions
WO2008013791A2 (en) * 2006-07-24 2008-01-31 University Of Delaware Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal
US9844528B2 (en) 2006-08-24 2017-12-19 University Of Tennessee Research Foundation SARMs and method of use thereof
US10010521B2 (en) 2006-08-24 2018-07-03 University Of Tennessee Research Foundation SARMs and method of use thereof
PT2054049E (pt) 2006-08-24 2016-06-02 Univ Tennessee Res Found Acilanilidas substituídas e métodos de utilização das mesmas
US9730908B2 (en) 2006-08-24 2017-08-15 University Of Tennessee Research Foundation SARMs and method of use thereof
US7968603B2 (en) 2007-09-11 2011-06-28 University Of Tennessee Research Foundation Solid forms of selective androgen receptor modulators
WO2010116342A2 (en) * 2009-04-10 2010-10-14 Consiglio Nazionale Delle Ricerche Non-steroidal compounds for androgen receptor modulation
ITBO20090236A1 (it) * 2009-04-10 2010-10-11 Consiglio Nazionale Ricerche Procedimento per la sintesi di composti per il trattamento del tumore alla prostata
WO2011008543A2 (en) * 2009-06-29 2011-01-20 University Of Delaware Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal
CN103539710A (zh) * 2012-07-02 2014-01-29 国药一心制药有限公司 一种（r）-比卡鲁胺的合成方法
US9744149B2 (en) 2012-07-13 2017-08-29 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US10987334B2 (en) 2012-07-13 2021-04-27 University Of Tennessee Research Foundation Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs)
US9622992B2 (en) 2012-07-13 2017-04-18 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US9969683B2 (en) 2012-07-13 2018-05-15 Gtx, Inc. Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS)
US10258596B2 (en) 2012-07-13 2019-04-16 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US10314807B2 (en) 2012-07-13 2019-06-11 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
IN2015DN01046A (xx) 2012-07-13 2015-06-26 Gtx Inc

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LU88769I2 (fr) * 1982-07-23 1996-11-05 Zeneca Ltd Bicalutamide et ses sels et esters pharmaceutiquement acceptables (Casodex (R))
GB8617652D0 (en) 1986-07-18 1986-08-28 Ici Plc Acylanilide derivatives
WO1995019770A1 (en) * 1994-01-21 1995-07-27 Sepracor, Inc. Methods and compositions for treating androgen-dependent diseases using optically pure r-(-)-casodex
AU7723198A (en) 1997-06-04 1998-12-21 University Of Tennessee Research Corporation, The Non-steroidal radiolabeled agonist/antagonist compounds and their use in prostate cancer imaging
US6186674B1 (en) * 1998-09-15 2001-02-13 Lucent Technologies, Inc. Optical sub-assembly package mount
US6252762B1 (en) * 1999-04-21 2001-06-26 Telcordia Technologies, Inc. Rechargeable hybrid battery/supercapacitor system
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AU2002231027A1 (en) * 2000-12-13 2002-06-24 Teraconnect, Inc. A packaging system for two-dimensional optoelectronic arrays
US6821032B2 (en) * 2002-05-28 2004-11-23 Intel Corporation Methods of sealing electronic, optical and electro-optical packages and related package and substrate designs

Also Published As

Publication number Publication date
CN1409702A (zh) 2003-04-09
US6583306B1 (en) 2003-06-24
IL149056A0 (en) 2002-11-10
EP1222165A2 (en) 2002-07-17
CZ20021340A3 (cs) 2002-08-14
BR0014889A (pt) 2002-12-31
NO20021831L (no) 2002-06-19
NZ518392A (en) 2004-02-27
IL149056A (en) 2011-05-31
MXPA02003884A (es) 2004-09-06
US7022869B2 (en) 2006-04-04
AU1968601A (en) 2001-04-30
PL354620A1 (en) 2004-02-09
WO2001028990A2 (en) 2001-04-26
NO20021831D0 (no) 2002-04-18
CA2387570A1 (en) 2001-04-26
HUP0203785A2 (hu) 2003-04-28
HK1048298A1 (zh) 2003-03-28
JP5112583B2 (ja) 2013-01-09
KR20020091047A (ko) 2002-12-05
US20040030130A1 (en) 2004-02-12
JP2003512351A (ja) 2003-04-02
WO2001028990A3 (en) 2001-09-07

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