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NO20021831D0 - Fremgangsmåte ved asymmetrisk syntese av enantiomerer av casodex, derivater derav og mellomprodukter derfra - Google Patents

Fremgangsmåte ved asymmetrisk syntese av enantiomerer av casodex, derivater derav og mellomprodukter derfra

Info

Publication number
NO20021831D0
NO20021831D0 NO20021831A NO20021831A NO20021831D0 NO 20021831 D0 NO20021831 D0 NO 20021831D0 NO 20021831 A NO20021831 A NO 20021831A NO 20021831 A NO20021831 A NO 20021831A NO 20021831 D0 NO20021831 D0 NO 20021831D0
Authority
NO
Norway
Prior art keywords
casodex
enantiomers
intermediates
derivatives
asymmetric synthesis
Prior art date
Application number
NO20021831A
Other languages
English (en)
Other versions
NO20021831L (no
Inventor
Nnochiri N Ekwuribe
Original Assignee
Nobex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nobex Corp filed Critical Nobex Corp
Publication of NO20021831D0 publication Critical patent/NO20021831D0/no
Publication of NO20021831L publication Critical patent/NO20021831L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D317/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
NO20021831A 1999-10-19 2002-04-18 Fremgangsmåte ved asymmetrisk syntese av enantiomerer av casodex, derivater derav og mellomprodukter derfra NO20021831L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16041299P 1999-10-19 1999-10-19
PCT/US2000/041233 WO2001028990A2 (en) 1999-10-19 2000-10-18 Methods of asymmetrically synthesizing enantiomers of casodex, its derivatives and intermediates thereof

Publications (2)

Publication Number Publication Date
NO20021831D0 true NO20021831D0 (no) 2002-04-18
NO20021831L NO20021831L (no) 2002-06-19

Family

ID=22576803

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20021831A NO20021831L (no) 1999-10-19 2002-04-18 Fremgangsmåte ved asymmetrisk syntese av enantiomerer av casodex, derivater derav og mellomprodukter derfra

Country Status (18)

Country Link
US (2) US6583306B1 (no)
EP (1) EP1222165A2 (no)
JP (1) JP5112583B2 (no)
KR (1) KR20020091047A (no)
CN (1) CN1409702A (no)
AU (1) AU1968601A (no)
BR (1) BR0014889A (no)
CA (1) CA2387570A1 (no)
CZ (1) CZ20021340A3 (no)
HK (1) HK1048298A1 (no)
HU (1) HUP0203785A2 (no)
IL (2) IL149056A0 (no)
MX (1) MXPA02003884A (no)
NO (1) NO20021831L (no)
NZ (1) NZ518392A (no)
PL (1) PL354620A1 (no)
WO (1) WO2001028990A2 (no)
ZA (1) ZA200202947B (no)

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US6998500B2 (en) 2000-08-24 2006-02-14 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US7026500B2 (en) 2000-08-24 2006-04-11 University Of Tennessee Research Foundation Halogenated selective androgen receptor modulators and methods of use thereof
US8445534B2 (en) 2000-08-24 2013-05-21 University Of Tennessee Research Foundation Treating androgen decline in aging male (ADAM)-associated conditions with SARMs
US7622503B2 (en) 2000-08-24 2009-11-24 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US8008348B2 (en) 2001-12-06 2011-08-30 University Of Tennessee Research Foundation Treating muscle wasting with selective androgen receptor modulators
US6838484B2 (en) 2000-08-24 2005-01-04 University Of Tennessee Research Foundation Formulations comprising selective androgen receptor modulators
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CA2469340A1 (en) 2001-12-06 2003-06-19 Gtx Inc. Treating muscle wasting with selective androgen receptor modulators
US8853266B2 (en) 2001-12-06 2014-10-07 University Of Tennessee Research Foundation Selective androgen receptor modulators for treating diabetes
KR100938188B1 (ko) * 2001-12-13 2010-01-21 스미또모 가가꾸 가부시키가이샤 비칼루타미드의 결정 및 그 제조 방법
KR20100112659A (ko) 2002-02-07 2010-10-19 지티엑스, 인코포레이티드 선택적 안드로겐 수용체 조절자를 이용한 양성 전립선 과형성증의 치료 방법
AU2003217304A1 (en) 2002-02-28 2003-09-16 The University Of Tennessee Research Corporation Radiolabeled selective androgen receptor modulators and their use in prostate cancer imaging and therapy
KR20040101251A (ko) 2002-02-28 2004-12-02 유니버시티 오브 테네시 리서치 파운데이션 다치환된 선택적 안드로겐 수용체 모듈레이터 및 이를사용하는 방법
US7772433B2 (en) 2002-02-28 2010-08-10 University Of Tennessee Research Foundation SARMS and method of use thereof
US7803970B2 (en) 2002-02-28 2010-09-28 University Of Tennessee Research Foundation Multi-substitued selective androgen receptor modulators and methods of use thereof
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US7741371B2 (en) 2002-06-17 2010-06-22 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
HRP20050038A2 (en) 2002-06-17 2005-08-31 University Of Tennessee Research Foundation N-bridged selective androgen receptor modulators and methods of use thereof
ATE419037T1 (de) * 2002-09-04 2009-01-15 Fraunhofer Ges Forschung Verwendung eines mittel zur therapie der herzhypertrophie
US20040063782A1 (en) * 2002-09-27 2004-04-01 Westheim Raymond J.H. Bicalutamide forms
US6818766B2 (en) 2002-10-02 2004-11-16 Synthon Bv Process for making bicalutamide and intermediates thereof
JP2006506369A (ja) 2002-10-15 2006-02-23 ユニバーシティ・オブ・テネシー・リサーチ・ファウンデーション メチレン架橋選択的アンドロゲン受容体調節剤及びその使用方法
US8309603B2 (en) 2004-06-07 2012-11-13 University Of Tennessee Research Foundation SARMs and method of use thereof
JP4322621B2 (ja) 2003-10-16 2009-09-02 住友化学株式会社 ４’−シアノ−３−［（４−フルオロフェニル）スルホニル］−２−ヒドロキシ−２−メチル−３’−トリフルオロメチルプロピオンアニリドの製造方法
EA200501761A1 (ru) 2003-12-16 2006-04-28 Джи Ти Икс, ИНК. Пролекарственные формы селективных модуляторов андрогеновых рецепторов и способы их применения
US9884038B2 (en) 2004-06-07 2018-02-06 University Of Tennessee Research Foundation Selective androgen receptor modulator and methods of use thereof
US9889110B2 (en) 2004-06-07 2018-02-13 University Of Tennessee Research Foundation Selective androgen receptor modulator for treating hormone-related conditions
WO2008013791A2 (en) * 2006-07-24 2008-01-31 University Of Delaware Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal
US9844528B2 (en) 2006-08-24 2017-12-19 University Of Tennessee Research Foundation SARMs and method of use thereof
US9730908B2 (en) 2006-08-24 2017-08-15 University Of Tennessee Research Foundation SARMs and method of use thereof
US10010521B2 (en) 2006-08-24 2018-07-03 University Of Tennessee Research Foundation SARMs and method of use thereof
CN101528214B (zh) 2006-08-24 2013-06-05 田纳西大学研究基金会 取代的n-酰基苯胺及其使用方法
US7968603B2 (en) 2007-09-11 2011-06-28 University Of Tennessee Research Foundation Solid forms of selective androgen receptor modulators
US8741951B2 (en) 2009-04-10 2014-06-03 CNR—Consiglio Nazionale Delle Ricerche Non-steroidal compounds for androgen receptor modulation
ITBO20090236A1 (it) * 2009-04-10 2010-10-11 Consiglio Nazionale Ricerche Procedimento per la sintesi di composti per il trattamento del tumore alla prostata
WO2011008543A2 (en) * 2009-06-29 2011-01-20 University Of Delaware Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal
CN103539710A (zh) * 2012-07-02 2014-01-29 国药一心制药有限公司 一种（r）-比卡鲁胺的合成方法
US9622992B2 (en) 2012-07-13 2017-04-18 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US10314807B2 (en) 2012-07-13 2019-06-11 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US9744149B2 (en) 2012-07-13 2017-08-29 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
PL2872482T3 (pl) 2012-07-13 2021-03-08 Oncternal Therapeutics, Inc. Sposób leczenia raków sutka z użyciem selektywnego modulatora receptora androgenowego (sarm)
US9969683B2 (en) 2012-07-13 2018-05-15 Gtx, Inc. Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS)
US10258596B2 (en) 2012-07-13 2019-04-16 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US10987334B2 (en) 2012-07-13 2021-04-27 University Of Tennessee Research Foundation Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs)

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LU88769I2 (fr) * 1982-07-23 1996-11-05 Zeneca Ltd Bicalutamide et ses sels et esters pharmaceutiquement acceptables (Casodex (R))
GB8617652D0 (en) 1986-07-18 1986-08-28 Ici Plc Acylanilide derivatives
JPH09508125A (ja) * 1994-01-21 1997-08-19 セプラコー，インコーポレイテッド 光学的純正ｒ−（−）−カソデックスを使用した男性ホルモン依存疾患治療のための方法と組成
AU7723198A (en) 1997-06-04 1998-12-21 University Of Tennessee Research Corporation, The Non-steroidal radiolabeled agonist/antagonist compounds and their use in prostate cancer imaging
US6186674B1 (en) * 1998-09-15 2001-02-13 Lucent Technologies, Inc. Optical sub-assembly package mount
US6252762B1 (en) * 1999-04-21 2001-06-26 Telcordia Technologies, Inc. Rechargeable hybrid battery/supercapacitor system
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AU2002231027A1 (en) * 2000-12-13 2002-06-24 Teraconnect, Inc. A packaging system for two-dimensional optoelectronic arrays
US6821032B2 (en) * 2002-05-28 2004-11-23 Intel Corporation Methods of sealing electronic, optical and electro-optical packages and related package and substrate designs

Also Published As

Publication number Publication date
NO20021831L (no) 2002-06-19
US6583306B1 (en) 2003-06-24
AU1968601A (en) 2001-04-30
CA2387570A1 (en) 2001-04-26
IL149056A (en) 2011-05-31
JP5112583B2 (ja) 2013-01-09
IL149056A0 (en) 2002-11-10
CN1409702A (zh) 2003-04-09
WO2001028990A2 (en) 2001-04-26
EP1222165A2 (en) 2002-07-17
BR0014889A (pt) 2002-12-31
KR20020091047A (ko) 2002-12-05
HUP0203785A2 (hu) 2003-04-28
CZ20021340A3 (cs) 2002-08-14
PL354620A1 (en) 2004-02-09
US20040030130A1 (en) 2004-02-12
HK1048298A1 (zh) 2003-03-28
ZA200202947B (en) 2003-09-23
MXPA02003884A (es) 2004-09-06
JP2003512351A (ja) 2003-04-02
US7022869B2 (en) 2006-04-04
WO2001028990A3 (en) 2001-09-07
NZ518392A (en) 2004-02-27

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