ZA200201789B - Substituted pyrrolidin-2,3,4-trion-3-oxime drivatives useful as NMDA-receptor antagonists. - Google Patents

Substituted pyrrolidin-2,3,4-trion-3-oxime drivatives useful as NMDA-receptor antagonists.

Info

Publication number: ZA200201789B
Authority: ZA; South Africa
Prior art keywords: drivatives; trion; nmda; oxime; useful
Prior art date: 1999-08-06

Application number

ZA200201789A

Other languages

English (en)

Inventor

Michael Przewosny

Hans-Dietrich Stachel

Hermann Poschenrieder

Original Assignee

Gruenenthal Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-08-06

Filing date

2002-03-04

Publication date

2003-06-25

2002-03-04 Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh

2003-06-25 Publication of ZA200201789B publication Critical patent/ZA200201789B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/20—Hypnotics; Sedatives
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- A61P25/24—Antidepressants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/12—Antivirals
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- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Addiction (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Psychology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Oncology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
AIDS & HIV (AREA)
Anesthesiology (AREA)
Molecular Biology (AREA)
Rheumatology (AREA)
Immunology (AREA)
Tropical Medicine & Parasitology (AREA)
Endocrinology (AREA)

ZA200201789A 1999-08-06 2002-03-04 Substituted pyrrolidin-2,3,4-trion-3-oxime drivatives useful as NMDA-receptor antagonists. ZA200201789B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19936521A DE19936521A1 (de)	1999-08-06	1999-08-06	Substituierte Pyrrolidin-2,3,4-trion-3-oxim-Derivate

Publications (1)

Publication Number	Publication Date
ZA200201789B true ZA200201789B (en)	2003-06-25

Family

ID=7917036

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200201789A ZA200201789B (en)	1999-08-06	2002-03-04	Substituted pyrrolidin-2,3,4-trion-3-oxime drivatives useful as NMDA-receptor antagonists.

Country Status (25)

Country	Link
US (1)	US6716872B2 (sk)
EP (1)	EP1200400B1 (sk)
JP (1)	JP2003506436A (sk)
KR (1)	KR20020025215A (sk)
CN (1)	CN1378531A (sk)
AR (1)	AR030678A1 (sk)
AT (1)	ATE277901T1 (sk)
AU (1)	AU779187B2 (sk)
BR (1)	BR0013313A (sk)
CA (1)	CA2380973A1 (sk)
CO (1)	CO5190692A1 (sk)
DE (2)	DE19936521A1 (sk)
ES (1)	ES2226876T3 (sk)
HK (1)	HK1046404A1 (sk)
HU (1)	HUP0202433A3 (sk)
IL (1)	IL147978A0 (sk)
MX (1)	MXPA02001215A (sk)
NO (1)	NO20020578L (sk)
NZ (1)	NZ516905A (sk)
PE (1)	PE20010381A1 (sk)
PL (1)	PL353875A1 (sk)
PT (1)	PT1200400E (sk)
SK (1)	SK1692002A3 (sk)
WO (1)	WO2001010831A1 (sk)
ZA (1)	ZA200201789B (sk)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3796692B2 (ja) *	2002-02-13	2006-07-12	農工大ティー・エル・オー株式会社	生物運動動作の観察自動化の方法及び装置、並びに特定の運動動作の定量化装置
RU2232578C1 (ru) *	2003-04-10	2004-07-20	Ахапкина Валентина Ивановна	Вещество, обладающее антидепрессивной активностью
US7732162B2 (en)	2003-05-05	2010-06-08	Probiodrug Ag	Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
JP5379692B2 (ja)	2006-11-09	2013-12-25	プロビオドルグエージー	潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
SI2091948T1 (sl)	2006-11-30	2012-07-31	Probiodrug Ag	Novi inhibitorji glutaminil ciklaze
ZA200905537B (en)	2007-03-01	2010-10-27	Probiodrug Ag	New use of glutaminyl cyclase inhibitors
EP2865670B1 (en)	2007-04-18	2017-01-11	Probiodrug AG	Thiourea derivatives as glutaminyl cyclase inhibitors
EP2475428B1 (en)	2009-09-11	2015-07-01	Probiodrug AG	Heterocylcic derivatives as inhibitors of glutaminyl cyclase
WO2011107530A2 (en)	2010-03-03	2011-09-09	Probiodrug Ag	Novel inhibitors
BR112012022478B1 (pt)	2010-03-10	2021-09-21	Probiodrug Ag	Inibidores heterocíclicos de glutaminil ciclase (qc, ec 2.3.2.5), seu processo de preparação, e composição farmacêutica
JP5945532B2 (ja)	2010-04-21	2016-07-05	プロビオドルグエージー	グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体
RU2432949C1 (ru) *	2010-08-26	2011-11-10	Государственное образовательное учреждение высшего профессионального образования "Астраханская государственная медицинская академия Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО АГМА Росздрава)	Способ коррекции нарушений иммунного и психоэмоционального статуса организма при экспериментальном информационном стрессе
ES2570167T3 (es)	2011-03-16	2016-05-17	Probiodrug Ag	Derivados de benzimidazol como inhibidores de glutaminil ciclasa
EP3461819B1 (en)	2017-09-29	2020-05-27	Probiodrug AG	Inhibitors of glutaminyl cyclase

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2832790A (en) *	1954-09-28	1958-04-29	Du Pont	4-negative functionally substituted 2, 3, 5-trichalcogenpyrrolidines, their salts, and methods for preparing them
DE4317651A1 (de) *	1993-05-27	1994-12-01	Hoechst Ag	Substituierte Bernsteinsäureimide
GB9418443D0 (en) *	1994-09-13	1994-11-02	Pfizer Ltd	Therapeutic agents
DE19732928C2 (de) *	1997-07-31	2000-05-18	Gruenenthal Gmbh	Verwendung substituierter Imidazolidin-2,4-dion-Verbindungen als Schmerzmittel

1999
- 1999-08-06 DE DE19936521A patent/DE19936521A1/de not_active Withdrawn
2000
- 2000-07-25 PT PT00945950T patent/PT1200400E/pt unknown
- 2000-07-25 DE DE50008020T patent/DE50008020D1/de not_active Expired - Lifetime
- 2000-07-25 CA CA002380973A patent/CA2380973A1/en not_active Abandoned
- 2000-07-25 EP EP00945950A patent/EP1200400B1/de not_active Expired - Lifetime
- 2000-07-25 PL PL00353875A patent/PL353875A1/xx not_active Application Discontinuation
- 2000-07-25 BR BR0013313-2A patent/BR0013313A/pt not_active IP Right Cessation
- 2000-07-25 SK SK169-2002A patent/SK1692002A3/sk unknown
- 2000-07-25 MX MXPA02001215A patent/MXPA02001215A/es not_active Application Discontinuation
- 2000-07-25 IL IL14797800A patent/IL147978A0/xx unknown
- 2000-07-25 WO PCT/EP2000/007101 patent/WO2001010831A1/de not_active Ceased
- 2000-07-25 HK HK02107775.4A patent/HK1046404A1/zh unknown
- 2000-07-25 JP JP2001515298A patent/JP2003506436A/ja not_active Withdrawn
- 2000-07-25 CN CN00813962A patent/CN1378531A/zh active Pending
- 2000-07-25 AU AU59868/00A patent/AU779187B2/en not_active Ceased
- 2000-07-25 KR KR1020027001609A patent/KR20020025215A/ko not_active Withdrawn
- 2000-07-25 NZ NZ516905A patent/NZ516905A/en not_active IP Right Cessation
- 2000-07-25 HU HU0202433A patent/HUP0202433A3/hu unknown
- 2000-07-25 ES ES00945950T patent/ES2226876T3/es not_active Expired - Lifetime
- 2000-07-25 AT AT00945950T patent/ATE277901T1/de active
- 2000-07-31 AR ARP000103962A patent/AR030678A1/es not_active Application Discontinuation
- 2000-08-01 PE PE2000000760A patent/PE20010381A1/es not_active Application Discontinuation
- 2000-08-03 CO CO00058415A patent/CO5190692A1/es not_active Application Discontinuation
2002
- 2002-02-05 NO NO20020578A patent/NO20020578L/no not_active Application Discontinuation
- 2002-02-06 US US10/066,801 patent/US6716872B2/en not_active Expired - Fee Related
- 2002-03-04 ZA ZA200201789A patent/ZA200201789B/xx unknown

Also Published As

Publication number	Publication date
NO20020578L (no)	2002-03-25
US6716872B2 (en)	2004-04-06
KR20020025215A (ko)	2002-04-03
PL353875A1 (en)	2003-12-01
MXPA02001215A (es)	2002-07-02
CO5190692A1 (es)	2002-08-29
NO20020578D0 (no)	2002-02-05
CA2380973A1 (en)	2001-02-15
PT1200400E (pt)	2005-02-28
DE50008020D1 (de)	2004-11-04
PE20010381A1 (es)	2001-05-05
ES2226876T3 (es)	2005-04-01
IL147978A0 (en)	2002-09-12
NZ516905A (en)	2004-07-30
HUP0202433A2 (hu)	2002-12-28
EP1200400B1 (de)	2004-09-29
ATE277901T1 (de)	2004-10-15
CN1378531A (zh)	2002-11-06
AR030678A1 (es)	2003-09-03
JP2003506436A (ja)	2003-02-18
EP1200400A1 (de)	2002-05-02
DE19936521A1 (de)	2001-02-15
US20030027852A1 (en)	2003-02-06
WO2001010831A1 (de)	2001-02-15
SK1692002A3 (en)	2002-07-02
BR0013313A (pt)	2002-04-16
HUP0202433A3 (en)	2003-06-30
HK1046404A1 (zh)	2003-01-10
AU779187B2 (en)	2005-01-13
AU5986800A (en)	2001-03-05

Publication	Publication Date	Title
AP2002002529A0 (en)	2002-06-30	2,4-Diaminopyrimidine compounds useful as immunosupressants
EP1235798A4 (en)	2003-04-23	1,4-SUBSTITUTED PIPERIDINYLE AS ANTAGONISTS OF NMDA / NR2B
ZA200201269B (en)	2003-02-14	Toothbrush.
ZA200203768B (en)	2003-08-11	Toothbrush.
ZA200107409B (en)	2003-01-29	Fuel composition.
ZA200108867B (en)	2003-03-26	Piperidine derivatives useful as CCR5 antagonists.
ZA200204395B (en)	2003-11-26	Selective neurokinin antagonists.
MXPA02001088A (es)	2003-09-22	2-pirazolin-5-onas..
ZA200201810B (en)	2004-05-26	Combined vaccine compositions.
MXPA01010670A (es)	2003-08-20	Composicion desinfectante a base de h2o2, acidos y iones metalicos.
ZA200004956B (en)	2002-02-27	Vaccine composition.
ZA200001591B (en)	2000-10-25	Polymer compositions.
IL149103A0 (en)	2002-11-10	2,4-diaminopyrimidine compounds useful as immunosuppressants
ZA200201829B (en)	2003-08-27	New phenylpiperazines.
MXPA03006991A (es)	2003-11-18	Derivados de piperidina como antagonistas de neurocinina 1.
ZA200201789B (en)	2003-06-25	Substituted pyrrolidin-2,3,4-trion-3-oxime drivatives useful as NMDA-receptor antagonists.
ZA200110127B (en)	2002-11-05	Substituted benzimidazole.
MXPA03001783A (es)	2003-06-04	N-(3,5-dicloro-2-metoxifenil)-4-metoxi-3- piperazin-1 -il -bencenosulfonamida.
AU2673201A (en)	2001-07-03	Alpha-arylethylpiperazine derivatives as neurokinin antagonists
GB2357283B (en)	2003-09-24	I.S. Machine
MXPA02000261A (es)	2003-08-20	Aminoindanos novedosos.
ZA200005697B (en)	2001-10-02	Paroxetine compositions.
GB2357285B (en)	2003-07-30	I.S. machine
GB2347421B (en)	2002-11-13	I.S. machine
GB2353794B (en)	2003-05-28	Deadplate assembly for I.S. machine