PE20010381A1 - Derivados de pirrolidin-2,3,4-trion-3-oxima sustituida, procedimientos para su preparacion, medicamentos que contienen estos cumpuestos y el uso de estos compuestos para la preparacion de medicamentos - Google Patents
Derivados de pirrolidin-2,3,4-trion-3-oxima sustituida, procedimientos para su preparacion, medicamentos que contienen estos cumpuestos y el uso de estos compuestos para la preparacion de medicamentosInfo
- Publication number
- PE20010381A1 PE20010381A1 PE2000000760A PE0007602000A PE20010381A1 PE 20010381 A1 PE20010381 A1 PE 20010381A1 PE 2000000760 A PE2000000760 A PE 2000000760A PE 0007602000 A PE0007602000 A PE 0007602000A PE 20010381 A1 PE20010381 A1 PE 20010381A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- heteroaryl
- aryl
- oxima
- trion
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000003814 drug Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 101100134922 Gallus gallus COR5 gene Proteins 0.000 abstract 3
- 208000007848 Alcoholism Diseases 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 201000006474 Brain Ischemia Diseases 0.000 abstract 1
- 206010012735 Diarrhoea Diseases 0.000 abstract 1
- 206010013654 Drug abuse Diseases 0.000 abstract 1
- 208000007882 Gastritis Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 206010046543 Urinary incontinence Diseases 0.000 abstract 1
- 206010001584 alcohol abuse Diseases 0.000 abstract 1
- 208000025746 alcohol use disease Diseases 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 206010008118 cerebral infarction Diseases 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 201000002491 encephalomyelitis Diseases 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 230000036407 pain Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Addiction (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
Abstract
SE REFIERE A DERIVADOS DE PIRROLIDIN-2,3,4-TRION-3-OXIMA SUSTITUIDO DE FORMULA I, DONDE R1 ES H, OR8, COR5, CSR5, NR6R7, COOR5, CONR6R7, CSNR6R7, ALQUILO C1-C10, ARILO, HETEROARILO; R2 Y R3 SON H, F, Cl, CF3, OR8, SR8, ALQUILO C1-C10, HETEROARILO, ARILO; R4 ES H, OH, OR8, SR8, COR5, COOR5, COCOR5, CONR6R7, CSNR6R7, ALQUILO C1-C10, ARILO, HETEROARILO; R5 ES H, ALQUILO C1-C10, ARILO, HETEROARILO; R6 Y R7 SON H, OR8, COR5, COOR5, ALQUILO C1-C10, ARILO, HETEROARILO; R8 ES ALQUILO C1-C10, ALQUILO C1-C6, ARILO, HETEROARILO. SON COMPUESTOS PREFERIDOS 5-(METOXIFENILMETILEN)PIRROLIDIN-2,3,4-TRION-3-OXIMA, 5-BROMOFENILMETILEN-PIRROLIDIN-2,3,4-TRION-3-OXIMA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I PUEDE SER UTIL PARA EL TRATAMIENTO DE DOLORES, REACCIONES ALERGICAS, INFLAMATORIAS, ALERGIAS, DEPRESIONES, ABUSO DE FARMACOS O ALCOHOL, GASTRITIS, DIARREA, INCONTINENCIA URINARIA, AFECCIONES CARDIOVASCULARES, ENFERMEDADES DE LAS VIAS RESPIRATORIAS, TOS, AFECCIONES PSIQUICAS, EPILEPSIA, ESQUIZOFRENIA, ENFERMEDAD DE ALZHEIMER, HUNTINGTON, PARKINSON, ISQUEMIAS CEREBRALES, INFARTOS CEREBRALES, PSICOSIS, PROFILAXIS DE APOPLEJIAS, EDEMAS CEREBRALES, ANOXIAS, ENCEFALOMIELITIS, SINDROME DE TOURETTE, ASFIXIA PERINATAL
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19936521A DE19936521A1 (de) | 1999-08-06 | 1999-08-06 | Substituierte Pyrrolidin-2,3,4-trion-3-oxim-Derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20010381A1 true PE20010381A1 (es) | 2001-05-05 |
Family
ID=7917036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000760A PE20010381A1 (es) | 1999-08-06 | 2000-08-01 | Derivados de pirrolidin-2,3,4-trion-3-oxima sustituida, procedimientos para su preparacion, medicamentos que contienen estos cumpuestos y el uso de estos compuestos para la preparacion de medicamentos |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6716872B2 (es) |
| EP (1) | EP1200400B1 (es) |
| JP (1) | JP2003506436A (es) |
| KR (1) | KR20020025215A (es) |
| CN (1) | CN1378531A (es) |
| AR (1) | AR030678A1 (es) |
| AT (1) | ATE277901T1 (es) |
| AU (1) | AU779187B2 (es) |
| BR (1) | BR0013313A (es) |
| CA (1) | CA2380973A1 (es) |
| CO (1) | CO5190692A1 (es) |
| DE (2) | DE19936521A1 (es) |
| ES (1) | ES2226876T3 (es) |
| HK (1) | HK1046404A1 (es) |
| HU (1) | HUP0202433A3 (es) |
| IL (1) | IL147978A0 (es) |
| MX (1) | MXPA02001215A (es) |
| NO (1) | NO20020578L (es) |
| NZ (1) | NZ516905A (es) |
| PE (1) | PE20010381A1 (es) |
| PL (1) | PL353875A1 (es) |
| PT (1) | PT1200400E (es) |
| SK (1) | SK1692002A3 (es) |
| WO (1) | WO2001010831A1 (es) |
| ZA (1) | ZA200201789B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040245477A1 (en) * | 2002-02-13 | 2004-12-09 | Hiroshi Matsuda | Automatic animal motion observation method and apparatus, and motion quantization apparatus |
| RU2232578C1 (ru) * | 2003-04-10 | 2004-07-20 | Ахапкина Валентина Ивановна | Вещество, обладающее антидепрессивной активностью |
| US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| JP5379692B2 (ja) | 2006-11-09 | 2013-12-25 | プロビオドルグ エージー | 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体 |
| DK2091948T3 (da) | 2006-11-30 | 2012-07-23 | Probiodrug Ag | Nye inhibitorer af glutaminylcyclase |
| AU2008220785B2 (en) | 2007-03-01 | 2013-02-21 | Vivoryon Therapeutics N.V. | New use of glutaminyl cyclase inhibitors |
| US9656991B2 (en) | 2007-04-18 | 2017-05-23 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| EP2475428B1 (en) | 2009-09-11 | 2015-07-01 | Probiodrug AG | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
| JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
| EA022420B1 (ru) | 2010-03-10 | 2015-12-30 | Пробиодруг Аг | Гетероциклические ингибиторы глутаминилциклазы (qc, ec 2.3.2.5) |
| WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
| RU2432949C1 (ru) * | 2010-08-26 | 2011-11-10 | Государственное образовательное учреждение высшего профессионального образования "Астраханская государственная медицинская академия Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО АГМА Росздрава) | Способ коррекции нарушений иммунного и психоэмоционального статуса организма при экспериментальном информационном стрессе |
| ES2570167T3 (es) | 2011-03-16 | 2016-05-17 | Probiodrug Ag | Derivados de benzimidazol como inhibidores de glutaminil ciclasa |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2832790A (en) * | 1954-09-28 | 1958-04-29 | Du Pont | 4-negative functionally substituted 2, 3, 5-trichalcogenpyrrolidines, their salts, and methods for preparing them |
| DE4317651A1 (de) * | 1993-05-27 | 1994-12-01 | Hoechst Ag | Substituierte Bernsteinsäureimide |
| GB9418443D0 (en) * | 1994-09-13 | 1994-11-02 | Pfizer Ltd | Therapeutic agents |
| DE19732928C2 (de) * | 1997-07-31 | 2000-05-18 | Gruenenthal Gmbh | Verwendung substituierter Imidazolidin-2,4-dion-Verbindungen als Schmerzmittel |
-
1999
- 1999-08-06 DE DE19936521A patent/DE19936521A1/de not_active Withdrawn
-
2000
- 2000-07-25 EP EP00945950A patent/EP1200400B1/de not_active Expired - Lifetime
- 2000-07-25 CN CN00813962A patent/CN1378531A/zh active Pending
- 2000-07-25 NZ NZ516905A patent/NZ516905A/en not_active IP Right Cessation
- 2000-07-25 WO PCT/EP2000/007101 patent/WO2001010831A1/de not_active Ceased
- 2000-07-25 PT PT00945950T patent/PT1200400E/pt unknown
- 2000-07-25 MX MXPA02001215A patent/MXPA02001215A/es not_active Application Discontinuation
- 2000-07-25 SK SK169-2002A patent/SK1692002A3/sk unknown
- 2000-07-25 HK HK02107775.4A patent/HK1046404A1/zh unknown
- 2000-07-25 HU HU0202433A patent/HUP0202433A3/hu unknown
- 2000-07-25 CA CA002380973A patent/CA2380973A1/en not_active Abandoned
- 2000-07-25 PL PL00353875A patent/PL353875A1/xx not_active Application Discontinuation
- 2000-07-25 JP JP2001515298A patent/JP2003506436A/ja not_active Withdrawn
- 2000-07-25 AU AU59868/00A patent/AU779187B2/en not_active Ceased
- 2000-07-25 KR KR1020027001609A patent/KR20020025215A/ko not_active Withdrawn
- 2000-07-25 ES ES00945950T patent/ES2226876T3/es not_active Expired - Lifetime
- 2000-07-25 AT AT00945950T patent/ATE277901T1/de active
- 2000-07-25 IL IL14797800A patent/IL147978A0/xx unknown
- 2000-07-25 DE DE50008020T patent/DE50008020D1/de not_active Expired - Lifetime
- 2000-07-25 BR BR0013313-2A patent/BR0013313A/pt not_active IP Right Cessation
- 2000-07-31 AR ARP000103962A patent/AR030678A1/es not_active Application Discontinuation
- 2000-08-01 PE PE2000000760A patent/PE20010381A1/es not_active Application Discontinuation
- 2000-08-03 CO CO00058415A patent/CO5190692A1/es not_active Application Discontinuation
-
2002
- 2002-02-05 NO NO20020578A patent/NO20020578L/no not_active Application Discontinuation
- 2002-02-06 US US10/066,801 patent/US6716872B2/en not_active Expired - Fee Related
- 2002-03-04 ZA ZA200201789A patent/ZA200201789B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT1200400E (pt) | 2005-02-28 |
| JP2003506436A (ja) | 2003-02-18 |
| CA2380973A1 (en) | 2001-02-15 |
| PL353875A1 (en) | 2003-12-01 |
| WO2001010831A1 (de) | 2001-02-15 |
| CN1378531A (zh) | 2002-11-06 |
| NO20020578L (no) | 2002-03-25 |
| BR0013313A (pt) | 2002-04-16 |
| HUP0202433A2 (hu) | 2002-12-28 |
| AR030678A1 (es) | 2003-09-03 |
| MXPA02001215A (es) | 2002-07-02 |
| DE19936521A1 (de) | 2001-02-15 |
| NO20020578D0 (no) | 2002-02-05 |
| HUP0202433A3 (en) | 2003-06-30 |
| ATE277901T1 (de) | 2004-10-15 |
| KR20020025215A (ko) | 2002-04-03 |
| ZA200201789B (en) | 2003-06-25 |
| IL147978A0 (en) | 2002-09-12 |
| US6716872B2 (en) | 2004-04-06 |
| US20030027852A1 (en) | 2003-02-06 |
| CO5190692A1 (es) | 2002-08-29 |
| NZ516905A (en) | 2004-07-30 |
| HK1046404A1 (zh) | 2003-01-10 |
| EP1200400B1 (de) | 2004-09-29 |
| DE50008020D1 (de) | 2004-11-04 |
| SK1692002A3 (en) | 2002-07-02 |
| AU779187B2 (en) | 2005-01-13 |
| AU5986800A (en) | 2001-03-05 |
| ES2226876T3 (es) | 2005-04-01 |
| EP1200400A1 (de) | 2002-05-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20010381A1 (es) | Derivados de pirrolidin-2,3,4-trion-3-oxima sustituida, procedimientos para su preparacion, medicamentos que contienen estos cumpuestos y el uso de estos compuestos para la preparacion de medicamentos | |
| BR0213612A (pt) | Composto, composição farmacêutica, uso do composto e método para tratamento de doença ou condição | |
| MA31373B1 (fr) | Composes amino-heterocycliques | |
| PE57898A1 (es) | Derivados de sulfonil urea | |
| MX2023013080A (es) | Inhibidores alostericos de cromenona del fosfoinositido 3-quinasa (pi3k) para el tratamiento de enfermedades. | |
| MA27734A1 (fr) | DERIVES HEXAHYDROPYRAZINO [1,2-a]PYRIMIDINE-4,7-DIONE SUBSTITUES SUR L'AZOTE, METHODE POUR LEUR PRODUCTION ET LEUR UTILISATION EN TANT QUE MEDICAMENTS | |
| BRPI0412893A (pt) | composto, composição farmacêutica, uso de um composto, e, métodos de prevenção, tratamento ou melhora de doenças ou condições inflamatórias, ou doenças ou condições oftálmicas, de tratamento ou melhora de cáncer e para a produção de um composto | |
| BR0316883A (pt) | Derivado de piridazin-3(2h)-ona, composto, processo para a preparação de um composto composição farmacêutica, uso do composto, método para o tratamento de um sujeito que está sofrendo de uma condição patológica ou doença susceptìvel de melhora por meio de inibição da fosfodiesterase 4 e produto de combinação | |
| PE20020721A1 (es) | Derivados de quinuclidina como agentes antimuscarinicos m3 | |
| RU2007124329A (ru) | ПРОИЗВОДНЫЕ 5-ГИДРОКСИБЕНЗОТИАЗОЛА В КАЧЕСТВЕ АГОНИСТОВ β2 АДРЕНОРЕЦЕПТОРОВ | |
| MA26727A1 (fr) | Derives nouveaux de pyrimidine inhibiteurs de sorbitol deshydrogenase, leur procede de preparation et compositions pharmaceutiques les contenant | |
| MA27654A1 (fr) | DERIVES HEXAHYDROPYRAZINO [1,2-a]-4,7-DIONE SUBSTITUES, METHODE POUR LEUR PRODUCTION ET LEUR UTILISATION EN TANT QUE MEDICAMENTS | |
| AR031680A1 (es) | Utilizacion de acrilamidas de quinuclidina para la preparacion de medicamentos, compuestos y composicion farmaceutica | |
| EA200100902A1 (ru) | Производные тетрагидропирана и их использование в качестве терапевтических агентов | |
| DE69100079D1 (de) | Naphthalin-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen. | |
| MA30652B1 (fr) | Composes organiques | |
| ECSP088863A (es) | Compuestos que son agonistas de receptores muscarínicos y que pueden ser eficaces en el tratamiento del dolor, la enfermedad de alzheimer y/o la esquizofrenia | |
| BRPI0519106A2 (pt) | compostos, uso destes, processo para sua fabricaÇço, composiÇÕes farmacÊuticas, mÉtodo para o tratamento e/ou profilaxia de doenÇas que sço associadas com a dpp-iv | |
| BRPI0413353A (pt) | composição farmacêutica contendo droga solúvel em água | |
| BRPI0407253A (pt) | Heterociclil-3-sulfonilindazóis como ligandos 5-hidroxitriptamina-6 processo de preparação dos mesmos, seus usos na preparação de uma composição farmacêutica e composição farmacêutica compreendendo os referidos compostos | |
| PE20010402A1 (es) | Derivados de 1,5-dihidropirrol-2-ona sustituida | |
| BR0213760A (pt) | Composto, composição farmacêutica, uso do composto e método para tratamento de doença ou condição | |
| BRPI0409739A (pt) | composto, composição farmacêutica, uso de composto, e, método para o tratamento de uma doença ou de um distúrbio | |
| ATE357453T1 (de) | Comt-inhibitoren | |
| PE20081160A1 (es) | Arilsulfonil-pirrolidinas como inhibidores 5-ht6 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |