ZA200107689B - 1-Arenesulfonyl-2-aryl-pyrrolidine and piperidine derivatives for the treatment of CNS disorders. - Google Patents

1-Arenesulfonyl-2-aryl-pyrrolidine and piperidine derivatives for the treatment of CNS disorders.

Info

Publication number: ZA200107689B
Authority: ZA; South Africa
Prior art keywords: arenesulfonyl; pyrrolidine; aryl; treatment; cns disorders
Prior art date: 1999-03-25

Application number

ZA200107689A

Other languages

English (en)

Inventor

Vincent Mutel

Juergen Wichmann

Eric Vieira

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-03-25

Filing date

2001-09-18

Publication date

2002-12-18

2001-09-18 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2002-12-18 Publication of ZA200107689B publication Critical patent/ZA200107689B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Endocrinology (AREA)
Heart & Thoracic Surgery (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Hydrogenated Pyridines (AREA)

ZA200107689A 1999-03-25 2001-09-18 1-Arenesulfonyl-2-aryl-pyrrolidine and piperidine derivatives for the treatment of CNS disorders. ZA200107689B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP99106004		1999-03-25

Publications (1)

Publication Number	Publication Date
ZA200107689B true ZA200107689B (en)	2002-12-18

Family

ID=8237852

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200107689A ZA200107689B (en)	1999-03-25	2001-09-18	1-Arenesulfonyl-2-aryl-pyrrolidine and piperidine derivatives for the treatment of CNS disorders.

Country Status (34)

Country	Link
US (1)	US6284785B1 (xx)
EP (1)	EP1165510B1 (xx)
JP (1)	JP3590589B2 (xx)
KR (1)	KR100452648B1 (xx)
CN (1)	CN1150165C (xx)
AR (1)	AR028817A1 (xx)
AT (1)	ATE305451T1 (xx)
AU (1)	AU765212B2 (xx)
BR (1)	BR0009278A (xx)
CA (1)	CA2368418C (xx)
CO (1)	CO5050296A1 (xx)
CZ (1)	CZ20013402A3 (xx)
DE (1)	DE60022867T2 (xx)
DK (1)	DK1165510T3 (xx)
ES (1)	ES2249249T3 (xx)
HK (1)	HK1044944B (xx)
HR (1)	HRP20010682A2 (xx)
HU (1)	HUP0200284A3 (xx)
IL (1)	IL145301A0 (xx)
JO (1)	JO2274B1 (xx)
MA (1)	MA26779A1 (xx)
MX (1)	MXPA01009623A (xx)
MY (1)	MY125295A (xx)
NO (1)	NO319948B1 (xx)
NZ (1)	NZ514037A (xx)
PE (1)	PE20001583A1 (xx)
PL (1)	PL204436B1 (xx)
RU (1)	RU2248350C2 (xx)
SI (1)	SI1165510T1 (xx)
TR (1)	TR200102789T2 (xx)
TW (1)	TW575561B (xx)
WO (1)	WO2000058285A1 (xx)
YU (1)	YU67601A (xx)
ZA (1)	ZA200107689B (xx)

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CN1295561A (zh)	1998-06-03	2001-05-16	Gpinil控股公司	N－杂环羧酸或羧酸等排物的n－结合氨磺酰
US6589978B2 (en)	2000-06-30	2003-07-08	Hoffman-La Roche Inc.	1-sulfonyl pyrrolidine derivatives
US20040267010A1 (en) *	2001-02-02	2004-12-30	Forbes Ian Thomson	Sulfonamide compounds, their preparation and use
TW200302717A (en) *	2002-02-06	2003-08-16	Schering Corp	Novel gamma secretase inhibitors
WO2005030128A2 (en) *	2003-09-23	2005-04-07	Merck & Co., Inc.	Pyrazole modulators of metabotropic glutamate receptors
CA2555399A1 (en) *	2004-02-20	2005-09-01	Novartis Ag	Dpp-iv inhibitors for treating neurodegeneration and cognitive disorders
EP1758884A2 (en) *	2004-05-20	2007-03-07	Elan Pharmaceuticals, Inc.	N-cyclic sulfonamido inhibitors of gamma secretase
JP5173192B2 (ja)	2004-09-30	2013-03-27	武田薬品工業株式会社	プロトンポンプ阻害薬
EP2258357A3 (en)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenesis with acetylcholinesterase inhibitor
CA2620333A1 (en)	2005-08-26	2007-03-01	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation
NZ566378A (en)	2005-08-30	2011-03-31	Takeda Pharmaceutical	1-Heterocyclylsulfonyl, 2-aminomethyl, 5-(hetero-) aryl substituted 1-H-pyrrole derivatives as acid secretion inhibitors
WO2007047978A2 (en)	2005-10-21	2007-04-26	Braincells, Inc.	Modulation of neurogenesis by pde inhibition
EP1942879A1 (en)	2005-10-31	2008-07-16	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
JP2009536669A (ja)	2006-05-09	2009-10-15	ブレインセルス，インコーポレイティド	アンジオテンシン調節による神経新生
WO2007134077A2 (en)	2006-05-09	2007-11-22	Braincells, Inc.	5 ht receptor mediated neurogenesis
KR20090064418A (ko)	2006-09-08	2009-06-18	브레인셀즈 인코퍼레이션	4-아실아미노피리딘 유도체 포함 조합물
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
US8933105B2 (en)	2007-02-28	2015-01-13	Takeda Pharmaceutical Company Limited	Pyrrole compounds
US8969387B2 (en)	2008-08-27	2015-03-03	Takeda Pharmaceutical Company Limited	Pyrrole compounds
WO2010099217A1 (en)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
GB201702221D0 (en)	2017-02-10	2017-03-29	Univ Of Sussex	Compounds
US10603313B2 (en)	2017-07-31	2020-03-31	Chiromics, LLC	Allosteric modulators of the mu opioid receptor
GB201803340D0 (en)	2018-03-01	2018-04-18	Univ Of Sussex	Compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK167393B1 (da) *	1985-12-30	1993-10-25	Roussel Uclaf	1-sulfonyl-2-oxo-pyrrolidinderivater, deres fremstilling og farmaceutiske praeparater med indhold deraf
US5194439A (en) *	1990-04-06	1993-03-16	John Wyeth & Brother Limited	N-(2,3-dihydro-1,4-benzodioxinyl)-N-substituted aminopyrido-fused cycloalkanes
DE69205287T2 (de) *	1991-12-18	1996-03-14	Schering Corp., Kenilworth, N.J.	Imidazolylalkyl- piperazin und -diazepin derivate als histamin h3 agonisten/antagonisten.
FR2685325B1 (fr) *	1991-12-20	1994-02-04	Adir Cie	Nouveaux derives de pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
GB9612884D0 (en) *	1996-06-20	1996-08-21	Smithkline Beecham Plc	Novel compounds

2000
- 2000-03-13 TW TW89104504A patent/TW575561B/zh active
- 2000-03-18 PL PL350679A patent/PL204436B1/pl not_active IP Right Cessation
- 2000-03-18 JP JP2000607988A patent/JP3590589B2/ja not_active Expired - Fee Related
- 2000-03-18 BR BR0009278-9A patent/BR0009278A/pt active Search and Examination
- 2000-03-18 EP EP00910863A patent/EP1165510B1/en not_active Expired - Lifetime
- 2000-03-18 RU RU2001126570/04A patent/RU2248350C2/ru not_active IP Right Cessation
- 2000-03-18 CN CNB008055300A patent/CN1150165C/zh not_active Expired - Fee Related
- 2000-03-18 CA CA002368418A patent/CA2368418C/en not_active Expired - Fee Related
- 2000-03-18 IL IL14530100A patent/IL145301A0/xx unknown
- 2000-03-18 HU HU0200284A patent/HUP0200284A3/hu unknown
- 2000-03-18 HK HK02106320.6A patent/HK1044944B/zh not_active IP Right Cessation
- 2000-03-18 HR HR20010682A patent/HRP20010682A2/hr not_active Application Discontinuation
- 2000-03-18 AT AT00910863T patent/ATE305451T1/de active
- 2000-03-18 DE DE60022867T patent/DE60022867T2/de not_active Expired - Lifetime
- 2000-03-18 SI SI200030753T patent/SI1165510T1/sl unknown
- 2000-03-18 DK DK00910863T patent/DK1165510T3/da active
- 2000-03-18 WO PCT/EP2000/002431 patent/WO2000058285A1/en not_active Ceased
- 2000-03-18 CZ CZ20013402A patent/CZ20013402A3/cs unknown
- 2000-03-18 YU YU67601A patent/YU67601A/sh unknown
- 2000-03-18 KR KR10-2001-7012227A patent/KR100452648B1/ko not_active Expired - Fee Related
- 2000-03-18 MX MXPA01009623A patent/MXPA01009623A/es active IP Right Grant
- 2000-03-18 AU AU32915/00A patent/AU765212B2/en not_active Ceased
- 2000-03-18 TR TR2001/02789T patent/TR200102789T2/xx unknown
- 2000-03-18 ES ES00910863T patent/ES2249249T3/es not_active Expired - Lifetime
- 2000-03-20 PE PE2000000241A patent/PE20001583A1/es not_active Application Discontinuation
- 2000-03-22 CO CO00020380A patent/CO5050296A1/es unknown
- 2000-03-23 JO JO200025A patent/JO2274B1/en active
- 2000-03-23 MY MYPI20001145A patent/MY125295A/en unknown
- 2000-03-23 AR ARP000101297A patent/AR028817A1/es unknown
- 2000-03-24 US US09/534,380 patent/US6284785B1/en not_active Expired - Fee Related
2001
- 2001-09-18 ZA ZA200107689A patent/ZA200107689B/xx unknown
- 2001-09-24 NO NO20014617A patent/NO319948B1/no unknown
- 2001-09-25 MA MA26339A patent/MA26779A1/fr unknown
2004
- 2004-01-30 NZ NZ514037A patent/NZ514037A/xx unknown

Also Published As

Publication number	Publication date
JO2274B1 (en)	2005-04-07
PL204436B1 (pl)	2010-01-29
HUP0200284A3 (en)	2003-04-28
ES2249249T3 (es)	2006-04-01
YU67601A (sh)	2004-09-03
TW575561B (en)	2004-02-11
CZ20013402A3 (cs)	2002-03-13
EP1165510A1 (en)	2002-01-02
AR028817A1 (es)	2003-05-28
RU2248350C2 (ru)	2005-03-20
NZ514037A (en)	2004-01-30
HK1044944A1 (en)	2002-11-08
JP2002540191A (ja)	2002-11-26
PL350679A1 (en)	2003-01-27
MY125295A (en)	2006-07-31
NO319948B1 (no)	2005-10-03
AU3291500A (en)	2000-10-16
MXPA01009623A (es)	2002-05-06
CN1150165C (zh)	2004-05-19
NO20014617L (no)	2001-09-24
MA26779A1 (fr)	2004-12-20
SI1165510T1 (sl)	2005-12-31
HK1044944B (zh)	2004-10-21
KR100452648B1 (ko)	2004-10-12
EP1165510B1 (en)	2005-09-28
HRP20010682A2 (en)	2002-10-31
TR200102789T2 (tr)	2002-04-22
CA2368418C (en)	2009-03-10
BR0009278A (pt)	2001-12-26
DE60022867D1 (de)	2006-02-09
WO2000058285A1 (en)	2000-10-05
CA2368418A1 (en)	2000-10-05
CN1345311A (zh)	2002-04-17
IL145301A0 (en)	2002-06-30
AU765212B2 (en)	2003-09-11
US6284785B1 (en)	2001-09-04
JP3590589B2 (ja)	2004-11-17
DK1165510T3 (da)	2006-02-06
DE60022867T2 (de)	2006-06-22
PE20001583A1 (es)	2001-01-15
HUP0200284A2 (en)	2002-06-29
NO20014617D0 (no)	2001-09-24
ATE305451T1 (de)	2005-10-15
CO5050296A1 (es)	2001-06-27
KR20010108403A (ko)	2001-12-07

Publication	Publication Date	Title
ZA200107689B (en)	2002-12-18	1-Arenesulfonyl-2-aryl-pyrrolidine and piperidine derivatives for the treatment of CNS disorders.
ZA200109073B (en)	2003-01-29	Compositions for treatment of disorders of the oesophagus.
IL149530A0 (en)	2002-11-10	A pyrrolidineacetamide derivative alone or in combination for treatment of cns disorders
HUP0400914A3 (en)	2007-05-29	Methods of treatment of mitochondrial disorders
HUP0103856A3 (en)	2003-11-28	Pharmaceutical composition for the treatment of acute disorders
IL143979A0 (en)	2002-04-21	Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression
AU5309400A (en)	2000-12-18	Methods and compositions for the treatment of neuroleptic and related disorders using sertindole derivatives
IL153425A0 (en)	2003-07-06	Sulfonyl-pyrrolidine derivatives useful for the treatment of neurological disorders
IL155589A0 (en)	2003-11-23	Novel amidoalkyl-piperidine and amidoalkyl-piperazine derivatives useful for the treatment of nervous system disorders
AU6910600A (en)	2001-03-19	Methods for the treatment of mental disorders
AU5908300A (en)	2001-01-22	Prevention and treatment of amyloid-associated disorders
AU2002215047A1 (en)	2002-06-03	Isoquinoline derivatives useful in the treatment of cns disorders
AU4498201A (en)	2001-10-15	Quinolinyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatment ofpain
AU7388101A (en)	2001-12-24	Indole derivatives useful for the treatment of cns disorders
EP1181308A4 (en)	2004-10-27	METHODS OF TREATING NEURONAL DEMENTIA ASSOCIATED WITH ATROPHY
PL347976A1 (en)	2002-05-06	Isonipecotamides for the treatment of integrin−mediated disorders
IL153605A0 (en)	2003-07-06	Indole derivatives useful for the treatment of cns disorders
ZA200110539B (en)	2003-03-24	Oxazinocarbazoles for the treatment of CNS diseases.
AU1028501A (en)	2001-05-14	Isoquinoline and quinazoline derivatives for the treatment of cns disorders
AU2080201A (en)	2001-06-18	Treatment of addiction disorders
PL351554A1 (en)	2003-05-05	Osanetant in the treatment of mood disorders
IL153254A0 (en)	2003-07-06	Indole derivatives useful for the treatment of cns disorders
ZA995212B (en)	2000-02-18	The use of aryl-cyclohexylamine derivatives against CNS disorders.
AU6007900A (en)	2001-02-13	Azetidine carboxamide derivatives for the treatment of cns disorders
IL153234A0 (en)	2003-07-06	Indole derivatives useful for the treatment of cns disorders