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YU39875B - Process for obtaining new derivatives of vinblastine leurocristine and leurosidine - Google Patents

Process for obtaining new derivatives of vinblastine leurocristine and leurosidine

Info

Publication number
YU39875B
YU39875B YU1138/80A YU113880A YU39875B YU 39875 B YU39875 B YU 39875B YU 1138/80 A YU1138/80 A YU 1138/80A YU 113880 A YU113880 A YU 113880A YU 39875 B YU39875 B YU 39875B
Authority
YU
Yugoslavia
Prior art keywords
leurocristine
leurosidine
vinblastine
obtaining new
new derivatives
Prior art date
Application number
YU1138/80A
Other languages
English (en)
Other versions
YU113880A (en
Inventor
G J Cullinan
K Gerzon
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of YU113880A publication Critical patent/YU113880A/xx
Publication of YU39875B publication Critical patent/YU39875B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Fodder In General (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
YU1138/80A 1973-04-02 1980-04-25 Process for obtaining new derivatives of vinblastine leurocristine and leurosidine YU39875B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34727573A 1973-04-02 1973-04-02

Publications (2)

Publication Number Publication Date
YU113880A YU113880A (en) 1982-05-31
YU39875B true YU39875B (en) 1985-04-30

Family

ID=23363051

Family Applications (3)

Application Number Title Priority Date Filing Date
YU817/74A YU39719B (en) 1973-04-02 1974-03-25 Process for obtaining new derivatives of vinbastine and leurocristine
YU1138/80A YU39875B (en) 1973-04-02 1980-04-25 Process for obtaining new derivatives of vinblastine leurocristine and leurosidine
YU1139/80A YU39876B (en) 1973-04-02 1980-04-25 Process for obtaining new vinblastine derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
YU817/74A YU39719B (en) 1973-04-02 1974-03-25 Process for obtaining new derivatives of vinbastine and leurocristine

Family Applications After (1)

Application Number Title Priority Date Filing Date
YU1139/80A YU39876B (en) 1973-04-02 1980-04-25 Process for obtaining new vinblastine derivatives

Country Status (28)

Country Link
JP (2) JPS5919117B2 (xx)
AR (2) AR204004A1 (xx)
AT (1) AT340605B (xx)
BE (1) BE813168A (xx)
BG (3) BG21612A3 (xx)
CA (1) CA1042428A (xx)
CH (1) CH603669A5 (xx)
CS (1) CS185223B2 (xx)
CY (1) CY1044A (xx)
DD (1) DD113538A5 (xx)
DE (1) DE2415980A1 (xx)
DK (1) DK141511B (xx)
ES (2) ES424882A1 (xx)
FR (1) FR2223044B1 (xx)
GB (1) GB1463575A (xx)
HK (1) HK20180A (xx)
HU (1) HU171572B (xx)
IE (1) IE39071B1 (xx)
IL (1) IL44415A (xx)
KE (1) KE3028A (xx)
MY (1) MY8100025A (xx)
NL (1) NL181079C (xx)
PH (1) PH13623A (xx)
RO (2) RO77533A (xx)
SE (1) SE416206B (xx)
SU (4) SU731900A3 (xx)
YU (3) YU39719B (xx)
ZA (1) ZA741674B (xx)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
GR69783B (xx) * 1976-09-08 1982-07-07 Lilly Co Eli
USRE30561E (en) 1976-12-06 1981-03-31 Eli Lilly And Company Vinca alkaloid intermediates
US4096148A (en) * 1976-12-06 1978-06-20 Eli Lilly And Company Oxazolidinedione derivatives of Vinca alkaloids
USRE30560E (en) * 1976-12-06 1981-03-31 Eli Lilly And Company Oxazolidinedione derivatives of Vinca alkaloids
US4203898A (en) 1977-08-29 1980-05-20 Eli Lilly And Company Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
US4199504A (en) * 1978-05-15 1980-04-22 Eli Lilly And Company Bridged cathranthus alkaloid dimers
US4210584A (en) 1979-01-15 1980-07-01 Eli Lilly And Company Vindesine synthesis
US4357334A (en) 1980-03-20 1982-11-02 Eli Lilly And Company Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
OA06421A (fr) * 1980-06-10 1981-09-30 Omnium Chimique Sa Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides.
LU83822A1 (fr) 1981-12-08 1983-09-01 Omnichem Sa Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
FR2623504B1 (fr) * 1987-11-25 1990-03-09 Adir Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
HUT76925A (hu) * 1995-04-04 1998-01-28 MTA Enzimológiai Intézet Bisz-indol-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények
US5948750A (en) * 1996-10-30 1999-09-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6326402B1 (en) 1998-08-12 2001-12-04 Octamer, Inc. Methods for treating viral infections using a compound capable of inhibiting microtubules
KR101345002B1 (ko) 2005-01-21 2013-12-31 아스텍스 테라퓨틱스 리미티드 제약 화합물
SG164368A1 (en) 2005-07-18 2010-09-29 Bipar Sciences Inc Treatment of cancer
AU2007292306A1 (en) 2006-09-05 2008-03-13 Bipar Sciences, Inc. Inhibition of fatty acid synthesis by PARP inhibitors and methods of treatment thereof
AU2007292387A1 (en) 2006-09-05 2008-03-13 Bipar Sciences, Inc. Treatment of cancer
EP2073807A1 (en) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmaceutical combinations
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
KR20100102609A (ko) 2007-11-12 2010-09-24 바이파 사이언스 인코포레이티드 Ｐａｒｐ 억제제를 단독으로 사용하거나 항종양제와 병용하여 유방암을 치료하는 방법
CN105121447B (zh) * 2013-04-19 2018-02-02 暨南大学 长春碱类衍生物及其制备方法和应用
CN113456797B (zh) * 2021-06-18 2024-03-08 暨南大学 长春碱类衍生物在制备治疗骨肉瘤和/或软组织肉瘤药物中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine

Also Published As

Publication number Publication date
YU39719B (en) 1985-04-30
YU113880A (en) 1982-05-31
SU623522A3 (ru) 1978-09-05
JPS5919117B2 (ja) 1984-05-02
ES446571A1 (es) 1977-06-16
AU6671974A (en) 1975-09-18
JPS59193895A (ja) 1984-11-02
DK141511B (da) 1980-04-08
PH13623A (en) 1980-08-07
CH603669A5 (xx) 1978-08-31
BG22831A3 (bg) 1977-04-20
NL181079C (nl) 1987-06-16
JPS6033837B2 (ja) 1985-08-05
RO77533A (ro) 1982-02-01
KE3028A (en) 1980-03-28
ATA267974A (de) 1977-04-15
IL44415A0 (en) 1974-06-30
AR204004A1 (es) 1975-11-12
GB1463575A (en) 1977-02-02
CS185223B2 (en) 1978-09-15
ZA741674B (en) 1975-10-29
NL7404423A (xx) 1974-10-04
JPS49128000A (xx) 1974-12-07
BE813168A (fr) 1974-10-02
NL181079B (nl) 1987-01-16
MY8100025A (en) 1981-12-31
RO73524A (ro) 1984-10-31
DE2415980A1 (de) 1974-10-10
IE39071L (en) 1974-10-02
HU171572B (hu) 1978-02-28
ES424882A1 (es) 1976-12-16
DK141511C (xx) 1980-09-29
CA1042428A (en) 1978-11-14
HK20180A (en) 1980-04-25
YU39876B (en) 1985-04-30
SU652896A3 (ru) 1979-03-15
SU784783A3 (ru) 1980-11-30
IE39071B1 (en) 1978-08-02
DE2415980C2 (xx) 1989-11-09
RO73524B (ro) 1984-11-30
BG21235A3 (bg) 1976-03-20
AR203882A1 (es) 1975-10-31
FR2223044B1 (xx) 1978-06-30
DD113538A5 (xx) 1975-06-12
CY1044A (en) 1980-08-01
BG21612A3 (bg) 1976-07-20
SE416206B (sv) 1980-12-08
AT340605B (de) 1977-12-27
IL44415A (en) 1978-08-31
SU731900A3 (ru) 1980-04-30
YU81774A (en) 1982-05-31
FR2223044A1 (xx) 1974-10-25
YU113980A (en) 1982-05-31

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