RO73524A - Procedeu de preparare a unor derivati de alcaloizi - Google Patents

Procedeu de preparare a unor derivati de alcaloizi

Info

Publication number: RO73524A
Authority: RO; Romania
Prior art keywords: alcaloids; derivatives; preparation; alcaloids derivatives
Prior art date: 1973-04-02

Application number

RO7478274A

Other languages

English (en)

French (fr)

Other versions

RO73524B (ro

Inventor

George J Culliman

Koert Gerzon

Original Assignee

Eli Lilly And Co,Us

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1973-04-02

Filing date

1974-04-02

Publication date

1984-10-31

1974-04-02 Application filed by Eli Lilly And Co,Us filed Critical Eli Lilly And Co,Us

1984-10-31 Publication of RO73524A publication Critical patent/RO73524A/ro

1984-11-30 Publication of RO73524B publication Critical patent/RO73524B/ro

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Fodder In General (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

RO78274A 1973-04-02 1974-04-02 Procedeu de preparare a unor derivati de alcaloizi RO73524B (ro)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US34727573A	1973-04-02	1973-04-02

Publications (2)

Publication Number	Publication Date
RO73524A true RO73524A (ro)	1984-10-31
RO73524B RO73524B (ro)	1984-11-30

Family

ID=23363051

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
RO78274A RO73524B (ro)	1973-04-02	1974-04-02	Procedeu de preparare a unor derivati de alcaloizi
RO7498695A RO77533A (ro)	1973-04-02	1974-04-02	Procedeu pentru prepararea unor derivati de vinblastina,leurozidina si leurocristina

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
RO7498695A RO77533A (ro)	1973-04-02	1974-04-02	Procedeu pentru prepararea unor derivati de vinblastina,leurozidina si leurocristina

Country Status (28)

Country	Link
JP (2)	JPS5919117B2 (ro)
AR (2)	AR204004A1 (ro)
AT (1)	AT340605B (ro)
BE (1)	BE813168A (ro)
BG (3)	BG21612A3 (ro)
CA (1)	CA1042428A (ro)
CH (1)	CH603669A5 (ro)
CS (1)	CS185223B2 (ro)
CY (1)	CY1044A (ro)
DD (1)	DD113538A5 (ro)
DE (1)	DE2415980A1 (ro)
DK (1)	DK141511B (ro)
ES (2)	ES424882A1 (ro)
FR (1)	FR2223044B1 (ro)
GB (1)	GB1463575A (ro)
HK (1)	HK20180A (ro)
HU (1)	HU171572B (ro)
IE (1)	IE39071B1 (ro)
IL (1)	IL44415A (ro)
KE (1)	KE3028A (ro)
MY (1)	MY8100025A (ro)
NL (1)	NL181079C (ro)
PH (1)	PH13623A (ro)
RO (2)	RO73524B (ro)
SE (1)	SE416206B (ro)
SU (4)	SU731900A3 (ro)
YU (3)	YU39719B (ro)
ZA (1)	ZA741674B (ro)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL48685A (en) *	1975-01-09	1980-03-31	Lilly Co Eli	Amides of vincadioline and vinblastine
GR69783B (ro) *	1976-09-08	1982-07-07	Lilly Co Eli
USRE30561E (en)	1976-12-06	1981-03-31	Eli Lilly And Company	Vinca alkaloid intermediates
US4096148A (en) *	1976-12-06	1978-06-20	Eli Lilly And Company	Oxazolidinedione derivatives of Vinca alkaloids
USRE30560E (en) *	1976-12-06	1981-03-31	Eli Lilly And Company	Oxazolidinedione derivatives of Vinca alkaloids
US4203898A (en)	1977-08-29	1980-05-20	Eli Lilly And Company	Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
US4199504A (en) *	1978-05-15	1980-04-22	Eli Lilly And Company	Bridged cathranthus alkaloid dimers
US4210584A (en)	1979-01-15	1980-07-01	Eli Lilly And Company	Vindesine synthesis
US4357334A (en)	1980-03-20	1982-11-02	Eli Lilly And Company	Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
LU83822A1 (fr) *	1981-12-08	1983-09-01	Omnichem Sa	Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
OA06421A (fr) *	1980-06-10	1981-09-30	Omnium Chimique Sa	Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides.
FR2623504B1 (fr) *	1987-11-25	1990-03-09	Adir	Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
HUT76925A (hu) *	1995-04-04	1998-01-28	MTA Enzimológiai Intézet	Bisz-indol-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények
US5948750A (en) *	1996-10-30	1999-09-07	Merck & Co., Inc.	Conjugates useful in the treatment of prostate cancer
US6326402B1 (en)	1998-08-12	2001-12-04	Octamer, Inc.	Methods for treating viral infections using a compound capable of inhibiting microtubules
AU2006207321B2 (en)	2005-01-21	2012-09-06	Astex Therapeutics Limited	Pharmaceutical compounds
ZA200800907B (en)	2005-07-18	2010-04-28	Bipar Sciences Inc	Treatment of cancer
JP2010502730A (ja)	2006-09-05	2010-01-28	バイパーサイエンシズ，インコーポレイティド	癌の治療法
JP2010502731A (ja)	2006-09-05	2010-01-28	バイパーサイエンシズ，インコーポレイティド	Ｐａｒｐ阻害剤による脂肪酸合成の阻害、及びその治療方法
JP5528807B2 (ja)	2006-10-12	2014-06-25	アステックス、セラピューティックス、リミテッド	複合薬剤
WO2008044041A1 (en)	2006-10-12	2008-04-17	Astex Therapeutics Limited	Pharmaceutical combinations
CN101917982B (zh)	2007-11-12	2013-03-20	彼帕科学公司	使用4-碘-3-硝基苯甲酰胺与抗肿瘤剂组合治疗乳腺癌
JP6250710B2 (ja) *	2013-04-19	2017-12-20	曁南大学	ビンブラスチン誘導体の調製方法
CN113456797B (zh) *	2021-06-18	2024-03-08	暨南大学	长春碱类衍生物在制备治疗骨肉瘤和/或软组织肉瘤药物中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3097137A (en) *	1960-05-19	1963-07-09	Canadian Patents Dev	Vincaleukoblastine

1974
- 1974-01-01 AR AR253105A patent/AR204004A1/es active
- 1974-03-13 IL IL44415A patent/IL44415A/xx unknown
- 1974-03-13 ZA ZA00741674A patent/ZA741674B/xx unknown
- 1974-03-13 IE IE532/74A patent/IE39071B1/xx unknown
- 1974-03-22 CA CA195,760A patent/CA1042428A/en not_active Expired
- 1974-03-25 GB GB1310174A patent/GB1463575A/en not_active Expired
- 1974-03-25 CY CY1044A patent/CY1044A/xx unknown
- 1974-03-25 YU YU817/74A patent/YU39719B/xx unknown
- 1974-03-29 FR FR7411519A patent/FR2223044B1/fr not_active Expired
- 1974-03-29 PH PH15676A patent/PH13623A/en unknown
- 1974-03-29 CH CH446374A patent/CH603669A5/xx not_active IP Right Cessation
- 1974-04-01 DK DK178774AA patent/DK141511B/da not_active IP Right Cessation
- 1974-04-01 NL NLAANVRAGE7404423,A patent/NL181079C/xx not_active IP Right Cessation
- 1974-04-01 SU SU742013753A patent/SU731900A3/ru active
- 1974-04-01 SE SE7404380A patent/SE416206B/xx not_active IP Right Cessation
- 1974-04-01 HU HU74EI00000538A patent/HU171572B/hu unknown
- 1974-04-01 CS CS7400002335A patent/CS185223B2/cs unknown
- 1974-04-01 AT AT267974A patent/AT340605B/de not_active IP Right Cessation
- 1974-04-02 DE DE2415980A patent/DE2415980A1/de active Granted
- 1974-04-02 ES ES424882A patent/ES424882A1/es not_active Expired
- 1974-04-02 BE BE1005847A patent/BE813168A/xx not_active IP Right Cessation
- 1974-04-02 BG BG028513A patent/BG21612A3/xx unknown
- 1974-04-02 RO RO78274A patent/RO73524B/ro unknown
- 1974-04-02 BG BG026279A patent/BG22831A3/xx unknown
- 1974-04-02 BG BG028514A patent/BG21235A3/xx unknown
- 1974-04-02 JP JP49037765A patent/JPS5919117B2/ja not_active Expired
- 1974-04-02 RO RO7498695A patent/RO77533A/ro unknown
- 1974-04-02 DD DD177632A patent/DD113538A5/xx unknown
1975
- 1975-01-08 AR AR257228A patent/AR203882A1/es active
- 1975-07-04 SU SU752151512A patent/SU784783A3/ru active
- 1975-07-09 SU SU752152020A patent/SU652896A3/ru active
1976
- 1976-03-31 ES ES446571A patent/ES446571A1/es not_active Expired
- 1976-12-20 SU SU762429453A patent/SU623522A3/ru active
1980
- 1980-02-27 KE KE3028A patent/KE3028A/xx unknown
- 1980-04-17 HK HK201/80A patent/HK20180A/xx unknown
- 1980-04-25 YU YU1139/80A patent/YU39876B/xx unknown
- 1980-04-25 YU YU1138/80A patent/YU39875B/xx unknown
1981
- 1981-12-30 MY MY25/81A patent/MY8100025A/xx unknown
1983
- 1983-12-16 JP JP58238722A patent/JPS6033837B2/ja not_active Expired

Also Published As

Publication number	Publication date
FR2223044A1 (ro)	1974-10-25
IL44415A0 (en)	1974-06-30
JPS6033837B2 (ja)	1985-08-05
HU171572B (hu)	1978-02-28
AU6671974A (en)	1975-09-18
YU113880A (en)	1982-05-31
PH13623A (en)	1980-08-07
CY1044A (en)	1980-08-01
AR203882A1 (es)	1975-10-31
KE3028A (en)	1980-03-28
JPS49128000A (ro)	1974-12-07
YU39875B (en)	1985-04-30
HK20180A (en)	1980-04-25
DK141511B (da)	1980-04-08
JPS5919117B2 (ja)	1984-05-02
BG21235A3 (bg)	1976-03-20
CH603669A5 (ro)	1978-08-31
DD113538A5 (ro)	1975-06-12
JPS59193895A (ja)	1984-11-02
BG21612A3 (bg)	1976-07-20
SU652896A3 (ru)	1979-03-15
ES446571A1 (es)	1977-06-16
DK141511C (ro)	1980-09-29
AR204004A1 (es)	1975-11-12
ES424882A1 (es)	1976-12-16
NL7404423A (ro)	1974-10-04
IE39071L (en)	1974-10-02
CS185223B2 (en)	1978-09-15
SU623522A3 (ru)	1978-09-05
RO73524B (ro)	1984-11-30
FR2223044B1 (ro)	1978-06-30
YU81774A (en)	1982-05-31
MY8100025A (en)	1981-12-31
GB1463575A (en)	1977-02-02
NL181079B (nl)	1987-01-16
SU731900A3 (ru)	1980-04-30
SE416206B (sv)	1980-12-08
ZA741674B (en)	1975-10-29
BG22831A3 (bg)	1977-04-20
IE39071B1 (en)	1978-08-02
ATA267974A (de)	1977-04-15
SU784783A3 (ru)	1980-11-30
YU39876B (en)	1985-04-30
YU39719B (en)	1985-04-30
NL181079C (nl)	1987-06-16
RO77533A (ro)	1982-02-01
IL44415A (en)	1978-08-31
BE813168A (fr)	1974-10-02
YU113980A (en)	1982-05-31
CA1042428A (en)	1978-11-14
AT340605B (de)	1977-12-27
DE2415980C2 (ro)	1989-11-09
DE2415980A1 (de)	1974-10-10

Publication	Publication Date	Title
RO73524A (ro)	1984-10-31	Procedeu de preparare a unor derivati de alcaloizi
RO66907A (ro)	1981-06-26	Procedeu pentru prepararea unor derivati de 2-acil-4-oxopirazinoizochinolina
RO66800A (ro)	1982-03-24	Procedeu de preparare a unor derivati benzoxazolici
RO73008A (ro)	1981-09-24	Procedeu pentru prepararea unor derivati de difenileter-4-trifluormetil-4-nitro halogenati
RO69296A (ro)	1981-08-30	Procedeu pentru prepararea unor derivati chinazolinici
RO71925A (ro)	1982-05-10	Procedeu de preparare a unor derivati ai acidului tiocarbonic
RO69607A (ro)	1980-08-15	Procedeu pentru prepararea unor 3-carbamoiloximetilcefalosporine
RO76173A (ro)	1982-09-09	Procedeu de preparare a unor produse etoxilate
RO68642A (ro)	1980-06-15	Procedeu pentru prepararea unor derivati de acid micofenolic
RO70568A (ro)	1980-08-15	Procedeu pentru prepararea unor derivati de 2-aril-amino-2-imidazoline
RO70772A (ro)	1981-09-24	Procedeu de preparare a unor derivati de oxazol
RO71575A (ro)	1982-02-26	Procedeu pentru prepararea unor derivati de pirido-benzodiazepinone
RO63750A (ro)	1980-06-15	Procedeu pentru prepararea unor derivati ai 5-pirazolonei
RO66059A (ro)	1981-05-30	Procedeu de obtinere a unor derivati de triazolochinoline
RO72713A (ro)	1982-09-09	Procedeu de preparare a unor derivati carbazolici
RO71309A (ro)	1981-08-30	Procedeu pentru prepararea unor derivati de benzo-sulfonil-uree
RO69155A (ro)	1981-03-30	Procedeu pentru prepararea unor derivati de 1-fenoxi-3-aminopropan-2-ol
RO70535A (ro)	1981-08-17	Procedeu pentru prepararea unor derivati ai 3-aminopirolului
RO87769A (ro)	1985-12-20	Procedeu pentru prepararea unor derivati de tiazolidina
RO68469A (ro)	1980-08-15	Procedeu pentru prepararea unor derivati ai propanolului
RO63766A (ro)	1983-02-01	Procedeu pentru prepararea unor derivati ai 1-fenoxi-3-aminopropan-2-olului
RO76124A (ro)	1981-04-30	Procedeu pentru prepararea unor derivati de 3-hidroximetilen-4-cromanona
RO70293A (ro)	1980-08-15	Procedeu de preparare a unor derivati n-hidrocarbilsulfenil ai n-alchil-n'-aril-formamidinelor
RO69156A (ro)	1981-11-24	Procedeu pentru prepararea unor derivati de alfa-metil-3,4-dihidroxifenilalanina
RO73178A (ro)	1982-09-09	Procedeu de preparare a acilamino-fenil-acetamidelor