WO2025216117A1 - Composition containing lipid peptide and sucrose ester - Google Patents

Abstract

[Problem] To provide a novel composition which contains a lipid peptide and a sucrose ester that comprises a contamination suppressing effect and a penetration enhancing effect. [Solution] This composition contains: a lipid peptide-type compound in which a peptide moiety formed by the repetition of at least two or more identical or different amino acids is bonded to a lipid moiety that is composed of an aliphatic group having 10-24 carbon atoms; a sucrose ester; a 1,2-alkanediol; a fatty acid; and water.

Description

Compositions Comprising Lipid Peptides and Sucrose Esters

The present invention relates to a composition comprising a lipid peptide and a sucrose ester.

Lipid peptides are used as excellent gelling agents due to the high level of safety and biocompatibility required for medical, cosmetic, and other applications (Patent Document 1).

In recent years, new functions have been discovered, such as anti-fouling effects (Patent Document 3) and penetration-promoting effects (Patent Document 4) due to the membranes formed by lipid peptides (Patent Document 2), increasing the usefulness of lipid peptide-containing compositions in medical, cosmetic, and other applications.

Patent No. 5700222 International Publication No. 2020/004649 International Publication No. 2021/132653 International Publication No. 2021/132668

Conventional lipid peptide-containing compositions tend to precipitate or sediment over time at low temperatures or room temperature, making it difficult to maintain dispersion stability.
Therefore, an object of the present invention is to provide a new lipid peptide composition that can be used safely and securely, prevents adhesion of particulate matter and the like at least at the same level as conventional lipid peptide compositions, has the effect of preventing contamination of skin, hair, clothing, or paper by such substances, and has the effect of promoting penetration of the composition into skin, hair, clothing, or paper, while also having high dispersion stability at low or room temperature.

The inventors discovered that a composition containing at least one lipid peptide-type compound, a sucrose ester, a 1,2-alkanediol, a fatty acid, and water can achieve the above-mentioned objectives, and thus completed the present invention.

That is, in a first aspect, the present invention relates to a composition containing a lipid peptide-type compound in which a peptide portion formed by repeating at least two or more identical or different amino acids is bound to a lipid portion consisting of an aliphatic group having 10 to 24 carbon atoms, a sucrose ester, a 1,2-alkanediol, a fatty acid, and water.
In a second aspect, the present invention relates to the composition according to the first aspect, wherein the sucrose ester is sucrose polystearate or sucrose stearate.
According to a third aspect, the present invention relates to the composition according to the first or second aspect, in which the 1,2-alkanediol is 1,2-pentanediol or 1,2-hexanediol.
In a fourth aspect, the present invention relates to a composition according to any one of the first to third aspects, wherein the lipid peptide-type compound comprises at least one of compounds represented by the following formulas (1) to (3) or pharmaceutically acceptable salts thereof:
(wherein R ¹ represents an aliphatic group having 9 to 23 carbon atoms, R ² represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may have a branched chain and which has 1 or 2 carbon atoms, R ³ represents a -(CH ₂ ) _n -X group, n represents a number from 1 to 4, and X represents an amino group, a guanidino group, a -CONH ₂ group, a 5-membered or 6-membered ring group which may have 1 to 3 nitrogen atoms, or a fused heterocyclic group composed of a 5-membered ring and a 6-membered ring.)
(In the formula, ^R4 represents an aliphatic group having 9 to 23 carbon atoms, ^R5 to ^R7 each independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms which may have a branched chain and which has 1 or 2 carbon atoms, or a -( _CH2 ) _n -X group, where n represents a number from 1 to 4, and X represents an amino group, a guanidino group, _{a -CONH2} group, a 5-membered or 6-membered ring group which may have 1 to 3 nitrogen atoms, or a fused heterocyclic group composed of a 5-membered ring and a 6-membered ring.)
(In the formula, ^R8 represents an aliphatic group having 9 to 23 carbon atoms, ^R9 to ^R12 each independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms which may have a branched chain and which has 1 or 2 carbon atoms, or a -( _CH2 ) _n -X group, where n represents a number from 1 to 4, and X represents an amino group, a guanidino group, a _-CONH2 group, a 5-membered or 6-membered ring group which may have 1 to 3 nitrogen atoms, or a fused heterocyclic group composed of a 5-membered ring and a 6-membered ring.)
According to a fifth aspect, the present invention relates to the composition according to any one of the first to fourth aspects, in which the fatty acid is stearic acid.
In a sixth aspect, the present invention relates to a composition according to any one of the first to fifth aspects, wherein the content of the lipid peptide compound is 0.0001% by mass or more and 0.5% by mass or less, relative to the total mass of the composition.
In a seventh aspect, the present invention relates to the composition according to any one of the first to fifth aspects, wherein the content of the lipid peptide compound is 0.001% by mass or more and 0.5% by mass or less, relative to the total mass of the composition; the content of the sucrose ester is 0.0005% by mass or more and 0.25% by mass or less, relative to the total mass of the composition; the content of the 1,2-alkanediol is 0.0014% by mass or more and 0.7% by mass or less, relative to the total mass of the composition; and the content of the fatty acid is 0.0001% by mass or more and 0.05% by mass or less, relative to the total mass of the composition; and the composition is a transparent dispersion at a temperature of 0° C. or more and 40° C. or less.
In an eighth aspect, the present invention relates to the composition according to the seventh aspect, in which the lipid peptide compound is palmitoyl-Gly-His.
In a ninth aspect, the present invention relates to a composition according to any one of the first to fifth aspects, in which the content of the lipid peptide compound is 1.0% by mass or more and 20.0% by mass or less, relative to the total mass of the composition.
In a tenth aspect, the present invention relates to the composition according to any one of the first to fifth aspects, wherein the content of the lipid peptide type compound is 4.0% by mass or more and 6.0% by mass or less, relative to the total mass of the composition; the content of the sucrose ester is 2.0% by mass or more and 3.0% by mass or less, relative to the total mass of the composition; the content of the 1,2-alkanediol is 5.6% by mass or more and 8.4% by mass or less, relative to the total mass of the composition; and the content of the fatty acid is 0.4% by mass or more and 0.6% by mass or less, relative to the total mass of the composition; and the breaking strength is 2.0 to 4.0 × 10 ⁵ Pa.
In an eleventh aspect, the present invention relates to the composition according to the tenth aspect, in which the lipid peptide-type compound is palmitoyl-Gly-His.
In a twelfth aspect, the present invention relates to a cosmetic comprising the composition according to any one of the first to fifth aspects, wherein the content of the lipid peptide compound is 0.0001% by mass or more and 5.0% by mass or less, relative to the total mass of the cosmetic.
In a thirteenth aspect, the present invention relates to a method for reducing damage to hair, the method including the steps of applying the cosmetic composition according to the twelfth aspect to hair and forming a film.
In a fourteenth aspect, the present invention relates to a method for improving the water resistance of hair, the method including the steps of applying the cosmetic composition according to the twelfth aspect to hair and forming a film.
In a fifteenth aspect, the present invention relates to a method according to the thirteenth or fourteenth aspect, wherein the lipid peptide compound is palmitoyl-Gly-His. In a sixteenth aspect, the present invention relates to a method for producing the composition according to any one of the first to fifth aspects, comprising the steps of mixing the components of the composition according to any one of the first to fifth aspects so that the content of the lipid peptide compound is 1.0% by mass or more and 20.0% by mass or less, relative to the total mass of the composition, stirring the mixture at room temperature or under heating, and allowing the mixture to cool to obtain a solid composition.
In a seventeenth aspect, the present invention relates to a method for producing a dispersion of a lipid peptide compound, the method comprising the steps of: mixing the components of the composition according to any one of the first to fifth aspects and stirring the mixture at room temperature or under heating to produce a composition having a lipid peptide compound content of 1.0% by mass or more and 20.0% by mass or less, relative to the total mass of the composition; and mixing the composition with water and stirring the mixture at room temperature or under heating to produce a liquid composition having a lipid peptide compound content of 0.0001% by mass or more and 0.5% by mass or less.
In an eighteenth aspect, the present invention relates to a method for producing a cosmetic preparation, the method comprising the following steps: mixing the components of the composition according to any one of the first to fifth aspects and stirring at room temperature or with heating to produce a composition in which the content of the lipid peptide type compound is 1.0% by mass or more and 20.0% by mass or less, relative to the total mass of the composition; storing the resulting composition at room temperature or a low temperature; mixing the composition with water and stirring at room temperature or with heating so that the content of the lipid peptide type compound is 0.0001% by mass or more and 0.5% by mass or less, and storing the resulting composition at room temperature or a low temperature; and mixing the composition with water, various solvents, and other additives without heating, and stirring at room temperature or a low temperature to produce a cosmetic preparation in which the content of the lipid peptide type compound is 0.0001% by mass or more and 0.5% by mass or less, relative to the total mass of the cosmetic preparation.
In a nineteenth aspect, the present invention relates to a method for producing a cosmetic preparation, the method comprising the following steps: mixing the components of the composition according to any one of the first to fifth aspects and stirring the mixture at room temperature or under heating to produce a composition in which the content of the lipid peptide type compound obtained is 1.0% by mass or more and 20.0% by mass or less, relative to the total mass of the composition; storing the composition obtained at room temperature or a low temperature; and heating the composition, mixing it with various solvents and other additives, and stirring the mixture to obtain a cosmetic preparation in which the content of the lipid peptide type compound is 0.0001% by mass or more and 5.0% by mass or less, relative to the total mass of the cosmetic preparation.
The present invention relates, as a twentieth aspect, to a method for promoting penetration of an active ingredient, the method including a film-forming step of forming a film comprising the composition according to the sixth aspect on the skin epidermis or hair surface.
In a twenty-first aspect, the present invention relates to a method for promoting penetration of an active ingredient, the method comprising a film-forming step of forming a film comprising the composition according to the ninth aspect on the skin epidermis or hair surface.
The present invention relates, in a twenty-second aspect, to a method for promoting penetration of an active ingredient, the method comprising a film-forming step of forming a film comprising the composition according to the twelfth aspect on the skin epidermis or hair surface.

According to the present invention, the lipid peptide compound used in the present invention is an extremely safe, artificial low-molecular-weight compound composed only of lipids and peptides. Furthermore, the lipid peptide composition of the present invention, which contains the specific lipid peptide compound, sucrose ester, 1,2-alkanediol, fatty acid, and water, can provide excellent effects on biological samples, including skin and hair, similar to conventional lipid peptide compositions. Specifically, the composition can form a lipid peptide film on the surface of skin, hair, clothing, or paper. This film prevents the adhesion of dust, pollen, particulate matter, and the like, and can prevent contamination of skin, hair, clothing, or paper by these substances. Furthermore, this film can protect skin, hair, clothing, or paper from UV damage. Furthermore, the formation of the film can promote penetration of the composition into skin, hair, clothing, or paper. Furthermore, the formed film repairs hair, thereby improving its humidity resistance, suppressing frizz, improving firmness and body, and imparting manageability and suppleness.
Furthermore, the lipid peptide composition of the present invention has antifouling and penetration-promoting effects, and is highly safe to living organisms, providing a novel lipid peptide composition that can be used safely and securely. Therefore, the composition of the present invention is extremely useful from the viewpoint of the high level of safety required for pharmaceutical and cosmetic applications.
The present invention also provides compositions containing lipid peptide compounds at various concentrations, which not only have the aforementioned safety features but also exhibit unique effects depending on the respective concentrations.
When the lipid peptide compound is present in an amount of 0.0001% by mass or more and 0.5% by mass or less relative to the total mass of the composition, the composition is uniformly dispersed in a liquid state without precipitation or sedimentation over time at low or normal temperatures, resulting in a dispersion with high dispersion stability. The dispersion can be mixed with other solvents and additives at normal or low temperatures without heating while remaining in liquid form, allowing further processing and easy handling. Furthermore, because the composition of the present invention, which is a dispersion, can maintain a stable dispersion state, it can be provided as a composition with excellent usability and appearance, for example, in pharmaceutical and cosmetic applications.
When the lipid peptide compound is present in an amount of 1.0% by mass or more and 20.0% by mass or less relative to the total mass of the composition, the composition becomes a white solid at room temperature, making it easier to store than a liquid, saving storage space and improving transportation efficiency. Furthermore, the dilution rate can be adjusted to suit the user's needs. Furthermore, the hardness of the solid can be adjusted by selecting an appropriate sucrose ester. A low hardness has the advantage of making it easier to scoop when weighing, while a high hardness prevents it from collapsing during transportation.
When the lipid peptide compound is present in an amount of 0.0001% by mass or more and 5.0% by mass or less relative to the total mass of the composition, a small amount of the lipid peptide compound is blended in the composition, but the composition can form an extremely thin lipid peptide film, and the thin film can achieve anti-fouling and penetration-promoting effects.Furthermore, by selecting an appropriate sucrose ester, it is possible to adjust the moisture penetration into the formed film.Higher penetration can enhance the moisturizing effect and the penetration-promoting effect of active ingredients, while lower penetration can exhibit a high waterproof effect.
Furthermore, according to the present invention, a cosmetic containing a lipid peptide compound in an amount of 0.0001% by mass or more and 5.0% by mass or less relative to the total mass obtained by diluting a lipid peptide composition can form an extremely thin lipid peptide film on the surface of skin, hair, clothing, or paper, making it suitable for daily use.

FIG. 1 is a graph showing the amount of nicotinamide permeated from a three-dimensional cultured epidermal model after a skin permeation test was conducted on the three-dimensional cultured epidermal model using aqueous dispersions of Pal-GH at 0.001% by mass, 0.0025% by mass, and 0.005% by mass, respectively, as in Example 1. FIG. 2 is a graph showing the amount of nicotinamide permeation detected from the reservoir solution after a skin permeation test was conducted on a three-dimensional cultured epidermal model using aqueous dispersions of Pal-GH at 0.001% by mass, 0.0025% by mass, and 0.005% by mass, respectively, of Example 1. FIG. 3 is a graph showing the amount of nicotinamide permeated from a three-dimensional cultured epidermal model after a skin permeation test was conducted on the three-dimensional cultured epidermal model using the 0.025% by mass aqueous dispersion of Pal-GH in Example 3, and the 0.005% by mass or 0.025% by mass aqueous dispersions of Pal-GH in Examples 4 and 5, respectively. FIG. 4 is a graph showing the amount of nicotinamide permeation detected from the reservoir solution after a skin permeation test was conducted on a three-dimensional cultured epidermal model using the 0.025% by mass aqueous dispersion of Pal-GH in Example 3, and the 0.005% by mass or 0.025% by mass aqueous dispersions of Pal-GH in Examples 4 and 5, respectively. FIG. 5 is a graph showing the amount of nicotinamide permeated from a three-dimensional cultured epidermal model after a skin permeation test was performed on the three-dimensional cultured epidermal model using the 0.025% by mass aqueous dispersion of Pal-GH in each of Examples 6 to 10 and the 0.05% by mass aqueous dispersion of Pal-GH in Example 11. FIG. 6 is a graph showing the amount of nicotinamide permeation detected from the reservoir solution after a skin permeation test was conducted on a three-dimensional cultured epidermal model using the 0.025 mass% Pal-GH aqueous dispersions of Examples 6 to 10 and the 0.05 mass% Pal-GH aqueous dispersion of Example 11. FIG. 7 is a graph showing the amount of nicotinamide permeated from the three-dimensional cultured epidermal model after a skin permeation test was conducted on the three-dimensional cultured epidermal model using each of the 0.05% by mass aqueous dispersions of Pal-GH in Examples 11 to 14. FIG. 8 is a graph showing the amount of nicotinamide permeation detected from the reservoir solution after a skin permeation test was conducted on a three-dimensional cultured epidermal model using each of the 0.05% by mass aqueous dispersions of Pal-GH from Examples 11 to 14. FIG. 9 is a photograph taken with a Schottky field emission scanning electron microscope of the surface of a fiber membrane formed on the surface of an artificial leather supplier sprayed with an aqueous dispersion of 0.05% by mass of Pal-GH in each of Examples 11 to 14. FIG. 10 is a photograph showing PM2.5 particles adhering to the surface of artificial leather supplementary material sprayed with purified water and then dried, and PM2.5 particles adhering to a fiber membrane formed on the surface of artificial leather supplementary material sprayed with an aqueous dispersion of 0.05% by mass of Pal-GH from each of Examples 11 to 14 and then dried. FIG. 11 is a graph showing the amount of water adsorption of hair treated with the 0.025% by mass aqueous dispersion of Pal-GH in Examples 3 and 5, compared with damaged hair not treated with a lipid peptide solution. FIG. 12 is a graph showing the amount of water adsorption of hair treated with a 1% by mass SDS solution, a 0.005% by mass Pal-GH and 1% by mass SDS solution of Example 10, and a 0.025% by mass Pal-GH and 1% by mass SDS solution of Example 10, compared to damaged hair not treated with a lipid peptide solution. FIG. 13 is a graph showing the results of measuring the amounts of lipid peptides that penetrated into and adhered to damaged hair treated with 0.001% by mass, 0.0025% by mass, and 0.005% by mass aqueous dispersions of Pal-GH in Examples 1 and 2, respectively. FIG. 14 is a graph showing the results of measuring the amount of lipid peptides that penetrated into and adhered to damaged hair treated with 0.0025% by mass, 0.005% by mass, and 0.025% by mass aqueous dispersions of Pal-GH in Examples 3 to 5, respectively. FIG. 15 is a graph showing the results of measuring the amounts of lipid peptides that penetrated into and adhered to damaged hair treated with 0.0025% by mass, 0.005% by mass, and 0.025% by mass aqueous dispersions of Pal-GH in Examples 9 and 10, respectively. 16 is a graph showing the results of measuring the amount of lipid peptides that penetrated into and adhered to damaged hair treated with a commercially available shampoo and conditioner containing succinic acid alone, or succinic acid and Preparation Example 1 or Preparation Example 2. The concentrations of succinic acid and Pal-GH were: 1% by mass succinic acid alone, 1% by mass succinic acid and 0.005% by mass Pal-GH (Example 16), and 1% by mass succinic acid and 0.005% by mass Pal-GH (Example 17). 17 is a graph showing the amount of succinic acid extracted from damaged hair treated with a commercially available shampoo and conditioner containing succinic acid alone, or succinic acid and Preparation Example 1 or Preparation Example 2. The concentrations of succinic acid and Pal-GH were: 1% by mass succinic acid alone, 1% by mass succinic acid and 0.005% by mass Pal-GH (Example 16), and 1% by mass succinic acid and 0.005% by mass Pal-GH (Example 17). 18 is a graph showing the results of measuring the amount of lipid peptides that penetrated into and adhered to damaged hair treated with a commercially available shampoo and conditioner containing succinic acid alone, or succinic acid and Preparation Example 3, Preparation Example 4, or Preparation Example 5. The concentrations of succinic acid and Pal-GH were: 1% by mass succinic acid alone, 1% by mass succinic acid and 0.025% by mass Pal-GH (Example 18), 1% by mass succinic acid and 0.025% by mass Pal-GH (Example 19), and 1% by mass succinic acid and 0.025% by mass Pal-GH (Example 20). 19 is a graph showing the amount of succinic acid extracted from damaged hair treated with a commercially available shampoo and conditioner containing succinic acid alone, or succinic acid and Preparation Example 3, Preparation Example 4, or Preparation Example 5. The concentrations of succinic acid and Pal-GH were: 1% by mass succinic acid alone, 1% by mass succinic acid and 0.025% by mass Pal-GH (Example 18), 1% by mass succinic acid and 0.025% by mass Pal-GH (Example 19), and 1% by mass succinic acid and 0.025% by mass Pal-GH (Example 20). FIG. 20 is a graph showing the results of measuring the breaking strength of the composition (5 mass% Pal-GH) of Preparation Example 5 shown in Example 5 and the compositions (5 mass% Pal-GH) of Comparative Preparation Examples 6 and 7 shown in Comparative Examples 6 and 7. FIG. 21 shows photographs of aqueous dispersions of Pal-GH compositions [from left to right: Example 5 (Preparation Example 5 diluted with water to a Pal-GH concentration of 0.25%), Comparative Example 4 (Comparative Preparation Example 4 diluted with water to a Pal-GH concentration of 0.25%), and Comparative Example 5 (Comparative Preparation Example 5 diluted with water to a Pal-GH concentration of 0.25%)]. FIG. 22 is a graph showing the measurement results of the water contact angle according to the example. FIG. 23 is a graph showing the results of measurement by the SAXS method for the Pal-GH compositions of Example 5 and Comparative Examples 4 and 5. FIG. 24 is a graph showing the results of measurement by the SAXS method for the Pal-GH aqueous dispersions of Example 5 and Comparative Examples 4 and 5.

The present invention relates to a composition containing a specific lipid peptide-type compound, a sucrose ester, a 1,2-alkanediol, a fatty acid, and water.
The composition of the present invention can form a film on the surface of skin, hair, nails, clothing, or paper, thereby preventing the adhesion of pollutants such as dust to the surface of skin, hair, clothing, or paper, thereby preventing contamination by these substances (anti-pollution effect), and also has the effect of promoting skin penetration, repairing hair, or preventing damage to hair due to ultraviolet rays.
Substances that need to be prevented from adhering to and contaminating the surface of skin, hair, clothing, or paper include dust, pollen, particulate matter (PM10, suspended particulate matter (SPM), PM2.5 (fine particulate matter, etc.)) that may be contained in air pollutants such as exhaust gases and factory smoke, and cigarette smoke, gaseous substances (SOx, CO, etc.), odorous substances, as well as allergens such as house dust and fungi, mites (including dead mites), and viruses such as influenza viruses.
Each component will be described below.

[Composition]
[Lipid peptide type compound]
As the lipid peptide type compound used in the composition of the present invention, in which a peptide portion formed by repeating at least two or more identical or different amino acids is bound to a lipid portion consisting of an aliphatic group having 10 to 24 carbon atoms (the total number of carbon atoms in the lipid portion is 10 to 24), for example, compounds (lipopeptides) represented by the following formulas (1) to (3) or pharmaceutically usable salts thereof (low molecular weight compounds having a lipid portion as a hydrophobic portion and a peptide portion as a hydrophilic portion) can be used.

In the above formula (1), R ¹ represents an aliphatic group having 9 to 23 carbon atoms, and preferably R ¹ is a linear aliphatic group having 11 to 23 carbon atoms which may have 0 to 2 unsaturated bonds.
Specific examples of the lipid moiety (acyl group) composed of ^R1 and the adjacent carbonyl group include lauroyl group, dodecylcarbonyl group, myristoyl group, tetradecylcarbonyl group, palmitoyl group, margalloyl group, oleoyl group, elideyl group, linoleoyl group, stearoyl group, vaccenoyl group, octadecylcarbonyl group, arachidoyl group, eicosylcarbonyl group, behenoyl group, elcanoyl group, docosylcarbonyl group, lignoceyl group, and nervonoyl group, and particularly preferred are lauroyl group, myristoyl group, palmitoyl group, margalloyl group, stearoyl group, oleoyl group, elideyl group, and behenoyl group.

In the above formula (1), ^R2 contained in the peptide portion represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms.
The alkyl group having 1 to 4 carbon atoms, which may have a branched chain having 1 or 2 carbon atoms, means an alkyl group having 1 to 4 carbon atoms in the main chain and which may have a branched chain having 1 or 2 carbon atoms, and specific examples thereof include a methyl group, an ethyl group, an n-propyl group, an i-propyl group, an n-butyl group, an i-butyl group, a sec-butyl group, and a tert-butyl group.
^R2 is preferably a hydrogen atom or an alkyl group having 1 to 3 carbon atoms and which may have a branched chain and has 1 carbon atom, and more preferably a hydrogen atom.
The alkyl group having 1 to 3 carbon atoms and which may have a branched chain of 1 carbon atom means an alkyl group having 1 to 3 carbon atoms in the main chain and which may have a branched chain of 1 carbon atom, and specific examples thereof include a methyl group, an ethyl group, an n-propyl group, an i-propyl group, an i-butyl group, and a sec-butyl group, and preferably a methyl group, an i-propyl group, an i-butyl group, or a sec-butyl group.

In the above formula (1), ^R3 represents a -( _CH2 )n-X group, where n is a number from ₁ to 4, and X represents an amino group, a guanidino group, a _-CONH2 group, a 5-membered or 6-membered ring group which may have 1 to 3 nitrogen atoms, or a fused heterocyclic group composed of a 5-membered ring and a 6-membered ring.
In the -( _CH2 )nX group representing ^R3 , X is preferably an amino group, a guanidino group, a carbamoyl group (-CONH2 _group ), a pyrrole group, an imidazole group, a pyrazole group, or an indole group, more preferably an imidazole group. Also, in the -( _CH2 )nX group, n is preferably 1 or 2, more preferably 1.
Therefore, the above-mentioned —(CH ₂ )n—X group preferably represents an aminomethyl group, a 2-aminoethyl group, a 3-aminopropyl group, a 4-aminobutyl group, a carbamoylmethyl group, a 2-carbamoylethyl group, a 3-carbamoylbutyl group, a 2-guanidinoethyl group, a 3-guanidinobutyl group, a pyrrolemethyl group, a 4-imidazolemethyl group, a pyrazolemethyl group, or a 3-indolemethyl group, more preferably a 4-aminobutyl group, a carbamoylmethyl group, a 2-carbamoylethyl group, a 3-guanidinobutyl group, a 4-imidazolemethyl group, or a 3-indolemethyl group, and even more preferably a 4-imidazolemethyl group.

A particularly suitable lipid peptide in the compound represented by formula (1) above as a lipid peptide-type compound is a compound formed from the following lipid portion and peptide portion (amino acid assembly portion). The abbreviations for amino acids are alanine (Ala), asparagine (Asn), glutamine (Gln), glycine (Gly), histidine (His), isoleucine (Ile), leucine (Leu), lysine (Lys), tryptophan (Trp), and valine (Val). : Lauroyl-Gly-His, Lauroyl-Gly-Gln, Lauroyl-Gly-Asn, Lauroyl-Gly-Trp, Lauroyl-Gly-Lys, Lauroyl-Ala-His, Lauroyl-Ala-Gln, Lauroyl-Ala-Asn, Lauroyl-Ala-Trp, Lauroyl-Ala-Lys; Myristoyl-Gly-His, Myristoyl-Gly-Gln, Myristoyl-Gly-Asn, Myristoyl-Gly-Trp, Myristoyl-Gly-Lys, Myristoyl-Ala-His, Myristoyl-Ala-Gln, Myristoyl-Ala-Asn, Myristoyl-Ala-Trp, Myristoyl-Ala-Lys; Palmitoyl palmitoyl-Gly-His, palmitoyl-Gly-Gln, palmitoyl-Gly-Asn, palmitoyl-Gly-Trp, palmitoyl-Gly-Lys, palmitoyl-Ala-His, palmitoyl-Ala-Gln, palmitoyl-Ala-Asn, palmitoyl-Ala-Trp, palmitoyl-Ala-Lys; Stearoyl-Gly-His, Stearoyl-Gly-Gln, Stearoyl-Gly-Asn, Stearoyl-Gly-Trp, Stearoyl-Gly-Lys, Stearoyl-Ala-His, Stearoyl-Ala-Gln, Stearoyl-Ala-Asn, Stearoyl-Ala-Trp, Stearoyl-Ala-Lys.

Most preferred are lauroyl-Gly-His, lauroyl-Ala-His, myristoyl-Gly-His, myristoyl-Ala-His, palmitoyl-Gly-His, palmitoyl-Ala-His, stearoyl-Gly-His, and stearoyl-Ala-His.

In the above formula (2), R ⁴ represents an aliphatic group having 9 to 23 carbon atoms, and preferred specific examples include the same groups as defined above for R ¹ .
In the above formula (2), ^R5 to ^R7 each independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms, or a -( _CH2 )n-X group, and preferably at least one of ^R5 to ^R7 represents a -( _CH2 )n-X group. n represents a number from 1 to 4, and X represents an amino group, a guanidino group, a _-CONH2 group, a 5-membered or 6-membered ring group which may have 1 to 3 nitrogen atoms, or a fused heterocyclic group composed of a 5 ^- membered ring and a 6-membered ring. Specific preferred examples of R5 to ^R7 include the same groups as defined above for ^R2 and ^R3 .

In the compound represented by formula (2) above, suitable lipid peptides are compounds formed from the following lipid portion and peptide portion (amino acid assembly portion). For example, lauroyl-Gly-Gly-His, myristoyl-Gly-Gly-His, myristoyl-Gly-Gly-Gln, myristoyl-Gly-Gly-Asn, myristoyl-Gly-Gly-Trp, myristoyl-Gly-Gly-Lys, myristoyl-Gly-Ala-His, myristoyl-Gly-Ala-Gln, myristoyl-Gly-Ala-A sn, myristoyl-Gly-Ala-Trp, myristoyl-Gly-Ala-Lys, myristoyl-Ala-Gly-His, myristoyl-Ala-Gly-Gln, myristoyl-Ala-Gly-Asn, myristoyl-Ala-Gly-Trp, myristoyl-Ala-Gly-Lys, myristoyl-Gly-His-Gly, myristoyl-His-Gly-Gl y, palmitoyl-Gly-Gly-His, palmitoyl-Gly-Gly-Gln, palmitoyl-Gly-Gly-Asn, palmitoyl-Gly-Gly-Trp, palmitoyl-Gly-Gly-Lys, palmitoyl-Gly-Ala-His, palmitoyl-Gly-Ala-Gln, palmitoyl-Gly-Ala-Asn, palmitoyl-Gly-Ala-Trp , Palmitoyl-Gly-Ala-Lys, Palmitoyl-Ala-Gly-His, Palmitoyl-Ala-Gly-Gln, Palmitoyl-Ala-Gly-Asn, Palmitoyl-Ala-Gly-Trp, Palmitoyl-Ala-Gly-Lys, Palmitoyl-Gly-His-Gly, Palmitoyl-His-Gly-Gly, Stearoyl-Gly-Gly-His.

Among these, the most preferred are lauroyl-Gly-Gly-His, myristoyl-Gly-Gly-His, palmitoyl-Gly-Gly-His, palmitoyl-Gly-His-Gly, palmitoyl-His-Gly-Gly, and stearoyl-Gly-Gly-His.

In the above formula (3), ^R8 represents an aliphatic group having 9 to 23 carbon atoms, and preferred specific examples include the same groups as defined above for ^R1 .
In the above formula (3), ^R9 to ^R12 each independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms, or a -( _CH2 )n-X group, and preferably at least one of ^R9 to ^R12 represents a -( _CH2 )n-X group. n represents a number from 1 to 4, and X represents an amino group, a guanidino group, a _-CONH2 group, a 5-membered or 6-membered ring group which may have 1 to 3 nitrogen atoms, or a fused heterocyclic group composed of a 5-membered ring and a 6-membered ring. Specific preferred examples of ^R9 to ^R12 include the same groups as defined above for ^R2 and ^R3 .

Therefore, among the compounds represented by the above formula (3), suitable lipid peptide compounds, particularly suitable lipid peptides, include lauroyl-Gly-Gly-Gly-His, myristoyl-Gly-Gly-Gly-His, palmitoyl-Gly-Gly-Gly-His, palmitoyl-Gly-Gly-His-Gly, palmitoyl-Gly-His-Gly-Gly, palmitoyl-His-Gly-Gly, palmitoyl-His-Gly-Gly, stearoyl-Gly-Gly-Gly-His, etc.

In the present invention, the amount of the lipid peptide compound to be added is adjusted depending on the intended use of the composition, as described below.
The lipid peptide type compound used in the present invention consists of at least one of the compounds (lipopeptides) represented by the above formulas (1) to (3) or pharmaceutically acceptable salts thereof, and these compounds can be used alone or in combination of two or more.

[Sucrose ester]
In the present invention, preferred sucrose esters include sucrose caprate, sucrose laurate, sucrose myristate, sucrose palmitate, sucrose stearate, sucrose oleate, sucrose arachidate, sucrose behenate, sucrose polystearate, sucrose stearate, etc., and particularly preferred sucrose esters are sucrose laurate, sucrose myristate, sucrose palmitate, sucrose stearate, sucrose polystearate, and sucrose stearate, more preferably sucrose polystearate and sucrose stearate, and most preferably sucrose stearate.

In the present invention, the amount of sucrose ester to be blended is, for example, 0.001% by mass to 20% by mass, preferably 0.005% by mass to 10.0% by mass, more preferably 0.01% by mass to 10.0% by mass, even more preferably 0.05% by mass to 5.0% by mass, and particularly preferably 0.1% by mass to 5.0% by mass, relative to the total mass of the composition.
The sucrose ester used in the present invention is at least one of the above sucrose esters, and these sucrose esters can be used alone or in combination of two or more.

[1,2-alkanediol]
The 1,2-alkanediol used in the present invention has the function of promoting the solubility of the lipid peptide type compound.
Specific examples of the 1,2-alkanediol include 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, and 1,2-decanediol. Preferred are 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol. More preferred are 1,2-pentanediol and 1,2-hexanediol. Most preferred is 1,2-pentanediol. The 1,2-alkanediol used in the present invention is at least one member of the above-mentioned 1,2-alkanediol group, and these 1,2-alkanediols can be used alone or in combination of two or more members.
In particular, when 1,2-pentanediol or 1,2-hexanediol is used, when the composition of the present invention containing the diol, lipid peptide, and sucrose ester is in a solid state, the diol functions to adjust the hardness at that time and also functions to adjust the water penetration of the lipid peptide film formed when added to a cosmetic product.

In the present invention, the amount of the 1,2-alkanediol to be blended can be, for example, 0.001% by mass to 60% by mass, preferably 0.001% by mass to 30% by mass, and more preferably 0.01% by mass to 10% by mass, relative to the total mass of the composition.
The 1,2-alkanediol used in the present invention is at least one of the above 1,2-alkanediols, and these 1,2-alkanediols can be used alone or in combination of two or more.

〔fatty acid〕
The composition of the present invention contains a fatty acid, which has the function of stabilizing the structure (fiber structure, membrane structure, etc.) of the lipid peptide type compound.
In the present invention, the fatty acid is preferably at least one selected from the group consisting of saturated and unsaturated fatty acids having 10 to 20 carbon atoms and salts of these fatty acids, such as capric acid, undecanoic acid, lauric acid, tridecanoic acid, myristic acid, pentadecanoic acid, palmitic acid, margaric acid, and stearic acid. More preferred are capric acid, lauric acid, myristic acid, palmitic acid, and stearic acid, with stearic acid being the most preferred.

In the present invention, the amount of the fatty acid to be blended can be, for example, 0.0001 to 10.0% by mass, preferably 0.005 to 5.0% by mass, and more preferably 0.01 to 1.0% by mass, relative to the total mass of the composition.
The fatty acid used in the present invention is at least one of the above fatty acids, and these fatty acids can be used alone or in combination of two or more.

[Other ingredients]
The composition of the present invention contains water. The composition of the present invention may contain, in addition to the lipid peptide compound, 1,2-alkanediol, sucrose ester, fatty acid, and water, an alcohol, a polyhydric alcohol, or a mixture thereof.

Examples of the above water include purified water, purified water, hard water, soft water, natural water, deep sea water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionized water, and cluster water.

The above-mentioned alcohols are monohydric alcohols, such as alcohols having 1 to 6 carbon atoms that dissolve in water in any proportion, specifically methanol, ethanol, 2-propanol, and i-butanol, as well as higher alcohols, specifically oleyl alcohol and phenoxy alcohol.

The polyhydric alcohols mentioned above are dihydric or higher alcohols (excluding the above 1,2-alkanediols), such as propylene glycol, 1,3-butanediol, 2-ethyl-1,3-hexanediol, glycerin, isopentyldiol, ethylhexanediol, erythrulose, ozonated glycerin, caprylyl glycol, glycol, (C15-18) glycol, (C20-30) glycol, diethylene glycol, diglycerin, dithiaoctanediol, DPG, thioglycerin, 1,10-decanediol, decylene glycol, triethylene glycol, methylhydroxymethylcyclohexanol, phytantriol, phenoxypropanediol, 1,2-butanediol, 2,3-butanediol, butylethylpropanediol, 1,2-hexanediol, hexylene glycol, pentylene glycol, methylpropanediol, menthanediol, lauryl glycol, and polypropylene glycol.

In the present invention, when a polyhydric alcohol is contained, the content thereof can be, for example, 0.001% by mass to 60% by mass, preferably 0.001% by mass to 30% by mass, and more preferably 0.01% by mass to 10% by mass.
In the present invention, when a polyhydric alcohol is contained, the polyhydric alcohol may be used alone or in combination of two or more kinds.

[Other additives]
The composition of the present invention may contain additives that can generally be used as cosmetic additives, quasi-drug additives, and pharmaceutical additives (additive components such as physiologically active substances and functional substances that are incorporated into topical skin preparations such as cosmetics, quasi-drugs, or pharmaceuticals) as needed.
Examples of additive ingredients such as physiologically active substances and functional substances that are blended into external skin preparations such as cosmetics, quasi-drugs, or medicines include pigments, oily bases, moisturizing agents, texture improvers, surfactants, polymers, thickeners, gelling agents, solvents, antioxidants, reducing agents, oxidizing agents, preservatives, antibacterial agents, disinfectants, chelating agents, pH adjusters, acids, alkalis, powders, inorganic salts, ultraviolet absorbers, whitening agents, vitamins and their derivatives, hair growth agents, blood circulation promoters - Examples of effective ingredients include stimulants, agents to prevent gray hair, hormones, anti-wrinkle agents, anti-aging agents, tightening agents, cooling agents, warming agents, wound healing promoters, irritation soothing agents, analgesics, cell activators, plant/animal/microbial extracts, antipruritics, exfoliating/dissolving agents, antiperspirants, cooling agents, astringents, enzymes, nucleic acids, fragrances, pigments/coloring agents/dyes, anti-inflammatory agents/anti-asthmatics, anti-chronic obstructive pulmonary disease agents, anti-allergic agents, immunomodulators, anti-infective agents, and antifungal agents.
The content of these other additives may vary depending on the type, but may be, for example, about 0.001 to 20% by mass, or about 0.01 to 10% by mass, relative to the total mass of the composition.

Preferred pigments include inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as red iron oxide (red iron oxide) and iron titanate; inorganic brown pigments such as gamma-iron oxide; inorganic yellow pigments such as yellow iron oxide and ochre; inorganic black pigments such as black iron oxide and low-order titanium oxide; inorganic purple pigments such as mango violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide, and cobalt titanate; inorganic blue pigments such as ultramarine and Prussian blue; pearl pigments such as titanium oxide-coated mica, titanium oxide-coated bismuth oxychloride, titanium oxide-coated talc, colored titanium oxide-coated mica, bismuth oxychloride, and fish scale leaf; extender pigments such as talc, sericite, mica, kaolin, calcium carbonate, magnesium carbonate, silicic anhydride, barium sulfate, and aluminum hydroxide; metal powder pigments such as aluminum powder, copper powder, and gold; surface-treated inorganic and metal powder pigments; organic pigments such as zirconium, barium, or aluminum lake; and surface-treated organic pigments.

Oil bases include higher (polyhydric) alcohols such as oleyl alcohol, jojoba alcohol, chimyl alcohol, selachyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, 2-octyldodecanol, and dimer diol; aralkyl alcohols such as benzyl alcohol and their derivatives; stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, palmitoleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, and eicosanoic acid. Sapentaenoic acid, isohexadecanoic acid, anteisohenicosanoic acid, long-chain branched fatty acids, dimer acids, hydrogenated dimer acids, etc.; hydrocarbons such as liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, and solid paraffin; candelilla wax, carnauba wax, rice wax, Japan wax, beeswax, montan wax, ozokerite, ceresin, Waxes such as paraffin wax, microcrystalline wax, petrolatum, Fischer-Tropsch wax, polyethylene wax, and ethylene-propylene copolymer; coconut oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadowfoam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, Vegetable oils and fats such as soybean oil, peanut oil, rice bran oil, cocoa butter, shea butter, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil, grapeseed oil, apricot oil (almond oil), and camellia oil; animal oils and fats such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, and turtle oil; animal waxes such as whale wax, lanolin, and orange roughy oil; liquid lanolin, reduced lanolin, adsorbed and refined lanolin, acetated lanolin, acetated liquid lanolin, hydroxylanolin, polyoxyethylene lanolin, lanolin fatty acids, hard lanolin fatty acids, lanolin alcohol Lanolins such as lanolin, lanolin alcohol acetate, and cetyl/lanolyl acetate esters; sterols such as cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol, and cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, N-lauroyl-L-glutamic acid di(cholesteryl/behenyl/octyldodecyl), N-lauroyl-L-glutamic acid di(cholesteryl) Acyl sarcosine alkyl esters such as N-lauroyl-L-glutamic acid di(phytosteryl/behenyl/octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl/octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl/octyldodecyl), N-lauroylsarcosine isopropyl, cholesteryl 12-hydroxystearate, cholesteryl macadamiate, phytosteryl macadamiate, phytosteryl isostearate, cholesteryl soft lanolinate, cholesteryl hard lanolinate, long chain fatty acids Sterol esters such as branched fatty acid cholesteryl and long-chain α-hydroxy fatty acid cholesteryl; lipid complexes such as phospholipid-cholesterol complex and phospholipid-phytosterol complex; octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl palmitate, octyldodecyl palmitate, cetyl octanoate, hexyldecyl octanoate, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isodecyl neopentanoate, isotridecyl neopentanoate Syl, Isostearyl Neopentanoate, Octyldodecyl Neodecanoate, Oleyl Oleate, Octyldodecyl Oleate, Octyldodecyl Ricinoleate, Octyldodecyl Lanolinate, Hexyldecyl Dimethyloctanoate, Octyldodecyl Erucate, Hydrogenated Castor Oil Isostearate, Ethyl Oleate, Ethyl Avocado Oil Fatty Acid, Isopropyl Myristate, Isopropyl Palmitate, Octyl Palmitate, Isopropyl Isostearate, Isopropyl Lanolinate, Diethyl Sebacate, Diethyl Sebacate Monoalcohol carboxylic acid esters such as isopropyl, dioctyl sebacate, diisopropyl adipate, dibutyloctyl sebacate, diisobutyl adipate, dioctyl succinate, and triethyl citrate; oxyacid esters such as cetyl lactate, diisostearyl malate, and hydrogenated castor oil monoisostearate; glyceryl trioctanoate (glyceryl tri-2-ethylhexanoate), glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, and tri(caprylic/capric)glyceryl Ceryl, Caprylic/Capric/Myristic/Stearic Triglyceride, Hydrogenated Rosin Triglyceride (Hydrogenated Ester Gum), Rosin Triglyceride (Ester Gum), Glyceryl Behenate Eicosandioate, Trimethylolpropane Trioctanoate, Trimethylolpropane Triisostearate, Neopentyl Glycol Dioctanoate, Neopentyl Glycol Dicaprate, 2-Butyl-2-Ethyl-1,3-Propanediol Dioctanoate, Propylene Glycol Dioleate, Pentaerythrityl Tetraoctanoate Lithritol, Hydrogenated Rosinate Pentaerythrityl, Ditrimethylolpropane Triethylhexanoate, Ditrimethylolpropane Isostearate/Sebacic Acid, Pentaerythrityl Triethylhexanoate, Dipentaerythrityl Hydroxystearate/Stearic Acid/Rosinate, Diglyceryl Diisostearate, Polyglyceryl Tetraisostearate, Polyglyceryl-10 Nonisostearate, Polyglyceryl-8 Deca-Erucate/Isostearate/Ricinoleate, Hexyldecanoate/Sebacic Acid ) diglyceryl oligoester, glycol distearate (ethylene glycol distearate), 3-methyl-1,5-pentanediol dineopentanoate, 2,4-diethyl-1,5-pentanediol dineopentanoate and other polyhydric alcohol fatty acid esters; diisopropyl dimer dilinoleate, diisostearyl dimer dilinoleate, di(isostearyl/phytosteryl) dimer dilinoleate, (phytosteryl/behenyl) dimer dilinoleate, (phytosteryl/isostearyl) dimer dilinoleate /cetyl/stearyl/behenyl), dimer acid or dimer diol derivatives such as dimer dilinoleyl dimer dilinoleate, dimer dilinoleyl diisostearate, dimer dilinoleyl hydrogenated rosin condensate, dimer dilinoleic acid hydrogenated castor oil, hydroxyalkyl dimer dilinoleyl ether; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide Fatty acid alkanolamides such as lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (palmitic acid MEA), palmitic acid diethanolamide (palmitic acid DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA); dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane (also simply cyclopentasiloxane)), phenyl Preferred examples of silicones include trimethicone, diphenyl dimethicone, phenyl dimethicone, stearoxypropyl dimethylamine, aminoethyl aminopropyl methicone/dimethicone copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, amino-modified silicones such as aminopropyl dimethicone and amodimethicone, cation-modified silicones, polyether-modified silicones such as dimethicone copolyol, polyglycerin-modified silicones, sugar-modified silicones, carboxylic acid-modified silicones, phosphate-modified silicones, sulfate-modified silicones, alkyl-modified silicones, fatty acid-modified silicones, alkyl ether-modified silicones, amino acid-modified silicones, peptide-modified silicones, fluorine-modified silicones, cation-modified and polyether-modified silicones, amino-modified and polyether-modified silicones, alkyl-modified and polyether-modified silicones, and polysiloxane-oxyalkylene copolymers; and fluorine-based oils such as perfluorodecane, perfluorooctane, and perfluoropolyether.

Humectants and texture enhancers include polyols and their polymers such as glycerin, trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, dipropylene glycol, polypropylene glycol, and ethylene glycol-propylene glycol copolymers; glycol alkyl ethers such as diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, and diethylene glycol dibutyl ether; water-soluble esters such as polyglyceryl-10 (eicosane diacid/tetradecanedioic acid) and polyglyceryl-10 tetradecanedioate; sugar alcohols such as sorbitol, xylitol, erythritol, mannitol, and maltitol; glucose, fructose, galactose, mannose, threose, xylose, and arabinose. Binose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ-cyclodextrin, and modified cyclodextrins such as maltosylated and hydroxyalkylated), β-glucan, chitin, chitosan, heparin and its derivatives, pectin, arabinogalactan, dextrin, dextran, glycogen, ethyl glucosides, sugars and derivatives thereof, such as hydroxypropyl methylcellulose, glucosyl ethyl methacrylate polymers or copolymers; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate, caronin sulfate, keratosulfate, dermatan sulfate; Tremella fuciformis extract, Tremella fuciformis polysaccharide; fucoidan; tuberose polysaccharide or naturally occurring polysaccharide; organic acids and salts thereof, such as citric acid, tartaric acid, and lactic acid; urea and its derivatives; 2-pyrrolidone-5-carboxylic acid and and their sodium salts; amino acids such as betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, glucosyamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, and taurine, and their salts; collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagen degradation peptides, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin degradation peptides, keratin degradation peptides, hydrolyzed keratin, conchiolin degradation peptides, hydrolyzed conchiolin, silk proteolytic peptides, hydrolyzed silk, sodium lauroyl hydrolyzed silk, soybean proteolytic peptides, wheat proteolytic peptides, and added Hydrolyzed wheat protein, casein hydrolyzed peptides, acylated peptides and other protein peptides and their derivatives; acylated peptides such as palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide; silylated peptides; lactic acid bacteria culture liquid, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesame lignan glycoside, glutathione, albumin, whey; choline chloride, phosphorylcholine; placenta extract, alastin, Preferred examples include animal and plant extracts such as collagen, aloe extract, witch hazel water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, rose rouge extract, yarrow extract, eucalyptus extract, and melilot extract, and ceramides such as natural ceramides (types 1, 2, 3, 4, 5, and 6), hydroxyceramides, pseudoceramides, glycosphingolipids, and extracts containing ceramides and glycoceramides.

Preferred surfactants include anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, polymer surfactants, etc. Preferred examples of the surfactant include anionic surfactants such as fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfate ester salts such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; polyoxyethylene alkyl sulfates such as sodium laureth sulfate and triethanolamine laureth sulfate; acyl N-methyl alkyl esters such as sodium cocoyl methyl taurate, potassium cocoyl methyl taurate, sodium lauroyl methyl taurate, sodium myristoyl methyl taurate, sodium lauroyl methyl alanine, sodium lauroyl sarcosine, triethanolamine lauroyl sarcosine, and sodium lauroyl glutamate methyl alanine; amino acid salts; acylamino acid salts such as sodium cocoyl glutamate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, and triethanolamine cocoyl alanine; polyoxyethylene alkyl ether acetates such as sodium laureth acetate; succinic acid ester salts such as sodium lauroyl monoethanolamide succinate; fatty acid alkanolamide ether carboxylates; acyl lactate salts; polyoxyethylene fatty amine sulfates; fatty acid alkanolamide sulfates; fatty acid glyceride sulfates such as sodium hydrogenated coconut oil fatty acid glycerin sulfate; alkylbenzene alkyl ether sulfosuccinates such as disodium lauryl sulfosuccinate, sodium monolauroyl monoethanolamide polyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate; alkyl benzene sulfonates such as sodium tetradecyl benzene sulfonate and triethanolamine tetradecyl benzene sulfonate; alkyl naphthalene sulfonates; alkanesulfonates; α-sulfofatty acid methyl ester salts; acyl isethionates; alkyl glycerols diethyl ether sulfonate salts; alkyl sulfoacetate salts; alkyl ether phosphate salts such as sodium laureth phosphate, sodium dilaureth phosphate, sodium trilaureth phosphate, and sodium monoolethphosphate; alkyl phosphate salts such as potassium lauryl phosphate; sodium caseinate; alkylaryl ether phosphate salts; fatty acid amide ether phosphate salts; phospholipids such as phosphatidylglycerol, phosphatidylinositol, and phosphatidic acid; silicone-based anionic surfactants such as carboxylic acid-modified silicone, phosphate-modified silicone, and sulfate-modified silicone; and nonionic surfactants such as laureths (polyoxyethylene lauryl ethers) and ceteths (polyoxyethylene cetyl ethers). Polyoxyethylene alkyl ethers with various polyoxyethylene addition numbers, such as steareth (polyoxyethylene stearyl ether), beheneth (polyoxyethylene behenyl ether), isosteareth (polyoxyethylene isostearyl ether), and octyldodeceth (polyoxyethylene octyldodecyl ether); polyoxyethylene alkyl phenyl ether; castor oils such as polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate diester, and polyoxyethylene hydrogenated castor oil maleic acid. and hydrogenated castor oil derivatives; polyoxyethylene phytosterols; polyoxyethylene cholesterol; polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene-polyoxypropylene cetyl ether, polyoxyethylene-polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene-polyoxypropylene monobutyl ether, polyoxyethylene-polyoxypropylene hydrogenated lanolin, polyoxyethylene-polyoxypropylene glycerin ether and other polyoxyethylene-polyoxypropylene alkyl ethers; polyoxyethylene-polyoxypropylene glycol; (poly)glycerin polyethers such as PPG-9 diglyceryl. Glycerin fatty acid partial esters such as glyceryl stearate, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, glyceryl coconut oil fatty acid, glycerin monocottonseed oil fatty acid, glycerin monoerucate, glycerin sesquioleate, α,α'-oleic acid pyroglutamic acid glycerin, glycerin monostearate malate, etc.; polyglyceryl-2, 3, 4, 5, 6, 8, 10, polyglyceryl-6, 10, polyglyceryl tristearate, polyglyceryl-10 decatenate, polyglyceryl-2 isostearate, 3, 4, 5, 6, 8, 10, diisostearyl Polyglycerin fatty acid esters such as Polyglyceryl-2 (diglyceryl diisostearate), Polyglyceryl-3, Polyglyceryl-10, Polyglyceryl-2 triisostearate, Polyglyceryl-2 tetraisostearate, Polyglyceryl-10 decaisostearate, Polyglyceryl-2 oleate, Polyglyceryl-3, 4, 5, 6, 8, 10, Polyglyceryl-6 dioleate, Polyglyceryl-2 trioleate, and Polyglyceryl-10 decaoleate; ethylene glycol mono fatty acid esters such as ethylene glycol monostearate; propylene glycol mono fatty acid esters such as propylene glycol monostearate; pentaerythritol partial fatty acid esters; sorbitol partial fatty acid esters; maltitol partial fatty acid esters esters; maltitol ethers; sorbitan fatty acid esters such as sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexanoate, and diglycerol sorbitan tetra-2-ethylhexanoate; partial esters of sugar derivatives such as methyl glucoside fatty acid esters and trehalose undecylenate; alkyl glucosides such as lauryl glucoside, (caprylyl/capryl) glucoside, and caprylyl glucoside; alkyl polyglycosides; lanolin alcohol; reduced lanolin; polyoxyethylene distearate, polyethylene Polyoxyethylene fatty acid mono- and diesters such as glycol diisostearate, polyoxyethylene monooleate, and polyoxyethylene dioleate; polyoxyethylene propylene glycol fatty acid esters; polyoxyethylene glycerin fatty acid esters such as polyoxyethylene monooleates such as polyoxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, and polyoxyethylene glycerin triisostearate; polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, and polyoxyethylene sorbitan tetraoleate Polyoxyethylene sorbitol fatty acid esters such as polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol pentaoleate, and polyoxyethylene sorbitol monostearate; polyoxyethylene methyl glucoside fatty acid esters; polyoxyethylene alkyl ether fatty acid esters; polyoxyethylene animal and vegetable oils and fats such as polyoxyethylene sorbitol beeswax; alkyl glyceryl ethers such as isostearyl glyceryl ether, chimyl alcohol, selachyl alcohol, and batyl alcohol; polyhydric alcohol alkyl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene, tetrapolyoxypropyl natural surfactants such as saponin and sophorolipid; polyoxyethylene fatty acid amides; fatty acid alkanolamides such as coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (palmitamide MEA), palmitic acid diethanolamide (palmitamide DEA), and coconut oil fatty acid methylethanolamide (cocamide methyl MEA); lauramine oxide, cocamine oxide, stearamine oxide, behenamine oxide, etc. alkyldimethylamine oxides; alkylethoxydimethylamine oxides; polyoxyethylene alkyl mercaptans; silicone-based nonionic surfactants such as polyether-modified silicones such as dimethicone copolyol, polysiloxane-oxyalkylene copolymers, polyglycerin-modified silicones, and sugar-modified silicones; cationic surfactants include alkyltrimethylammonium chlorides such as behentrimonium chloride, steartrimonium chloride, cetrimonium chloride, and lauryltrimonium chloride; alkyltrimethylammonium bromides such as stearyltrimonium bromide; dialkyldimethylammonium chlorides such as distearyldimonium chloride and dicocodimonium chloride; amides; fatty acid amidoamines and salts thereof such as stearamidopropyl dimethylamine and stearamidoethyl diethylamine; alkyl ether amines and salts or quaternary salts thereof such as stearoxypropyl dimethylamine; fatty acid amide quaternary ammonium salts such as ethyl sulfate long-chain branched fatty acid (12-31) aminopropylethyl dimethylammonium and ethyl sulfate lanolin fatty acid aminopropylethyl dimethylammonium; polyoxyethylene alkylamines and salts or quaternary salts thereof; alkylamine salts; fatty acid amide guanidinium salts; alkyl ether amine ammonium salts; alkyl trialkylene glycol ammonium salts; benzalkonium salts; benzethonium salts; pyridinium salts such as cetylpyridinium chloride; imidazolinium alkylisoquinolinium salts; dialkylmorphonium salts; polyamine fatty acid derivatives; silicone-based cationic surfactants such as amino-modified silicones such as aminopropyl dimethicone and amodimethicone, cation-modified silicones, cation-modified and polyether-modified silicones, and amino-modified and polyether-modified silicones; amphoteric surfactants include N-alkyl-N,N-dimethyl amino acid betaines such as lauryl betaine (lauryl dimethyl amino acetate betaine); fatty acid amidoalkyl-N,N-dimethyl amino acid betaines such as cocamidopropyl betaine and lauramidopropyl betaine; imidazoline betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkyldimethyl taurine, etc. sulfate-type betaines such as alkyldimethylaminoethanol sulfate esters; phosphate-type betaines such as alkyldimethylaminoethanol phosphate esters; sphingophospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin, phospholipids such as lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid, and hydroxide lecithin; silicone-based amphoteric surfactants; and preferred polymer surfactants include polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, and acrylic acid/alkyl methacrylate copolymers; and various silicone-based surfactants.

Polymers, thickeners, and gelling agents include guar gum, locust bean gum, queen seed, carrageenan, galactan, gum arabic, tara gum, tamarind, furcellaran, karaya gum, abelmoschus abies, carrageenan, tragacanth gum, pectin, pectinic acid and its sodium salt and other salts, alginic acid and its sodium salt and other salts, mannan; starches from rice, corn, potato, wheat, etc.; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salts, xanthan gum, pullulan, gelatin Langum, chitin, chitosan, agar, cassou extract, chondroitin sulfate, casein, collagen, gelatin, albumin; cellulose and its derivatives such as methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose and its salts such as sodium salt, methylhydroxypropylcellulose, sodium cellulose sulfate, dialkyldimethylammonium cellulose sulfate, crystalline cellulose, cellulose powder; soluble starch, Starch-based polymers such as carboxymethyl starch, methylhydroxypropyl starch, methyl starch, and the like; starch derivatives such as hydroxypropyltrimonium starch chloride, corn starch aluminum octenylsuccinate, and the like; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), vinylpyrrolidone-vinyl alcohol copolymer, polyvinyl methyl ether; polyethylene glycol, polypropylene glycol, polyoxyethylene-polyoxypropylene copolymer; amphoteric methacrylate ester copolymers such as (methacryloyloxyethyl carboxybetaine/alkyl methacrylate) copolymer, (acrylates/stearyl acrylate/ethylamine oxide methacrylate) copolymer; (dimethicone/vinyl dimethicone) crosspolymer, (alkyl acrylate/diacetone acrylamide) copolymer, (alkyl acrylate/diacetone acrylamide) copolymer AMP; partially saponified polyvinyl acetate, maleic acid copolymer; vinylpyrrolidone acrylic acid/dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water-dispersible polyester; polyacrylamide; polyacrylic acid ester copolymers such as polyethyl acrylate, carboxyvinyl polymer, polyacrylic acid and its salts such as sodium salt, acrylic acid/methacrylic acid ester copolymer; acrylic acid/alkyl methacrylate copolymer; cationized cellulose such as Polyquaternium-10, diallyldimethylammonium chloride/acrylamide copolymer such as Polyquaternium-7, acrylic acid/diallyldimethylammonium chloride copolymer such as Polyquaternium-22, acrylic acid/diallyldimethylammonium chloride/acrylamide copolymer such as Polyquaternium-39, acrylic acid/cationized methacrylic acid ester copolymer, acrylic acid/cationized methacrylic acid amide copolymer, acrylic acid/methyl acrylate/methacrylamidopropyltrimethylammonium chloride copolymer such as Polyquaternium-47, methacrylic acid chloride choline ester polymer; cationized oligosaccharide, cationized decaacrylate Preferred examples of the polymer include cationized polysaccharides such as xanthran and guar hydroxypropyltrimonium chloride; polyethyleneimine; cationic polymers; 2-methacryloyloxyethyl phosphorylcholine polymers such as polyquaternium-51 and copolymers with butyl methacrylate copolymers; acrylic resin emulsions, polyethyl acrylate emulsions, polyacrylic alkyl ester emulsions, polyvinyl acetate resin emulsions, natural rubber latex, synthetic latex and other polymer emulsions; nitrocellulose; polyurethanes and various copolymers; various silicones; various silicone copolymers such as acrylic-silicone graft copolymers; various fluorine-containing polymers; 12-hydroxystearic acid and salts thereof; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate; silicic anhydride, fumed silica (ultrafine particle silicic anhydride), aluminum magnesium silicate, sodium magnesium silicate, metal soaps, dialkyl phosphate metal salts, bentonite, hectorite, organically modified clay minerals, and fructooligosaccharide fatty acid esters. Among the above examples, cellulose and its derivatives, alginic acid and its salts, polyvinyl alcohol, hyaluronic acid and its salts, and collagen are preferred.

Preferred examples of solvents include lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol, and isobutyl alcohol; glycols such as propylene glycol, diethylene glycol, dipropylene glycol, and isopentyl diol; glycol ethers such as diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, and dipropylene glycol monoethyl ether; glycol ether esters such as ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate, and propylene glycol monoethyl ether acetate; glycol esters such as diethoxyethyl succinate and ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, N-methylpyrrolidone, and toluene.

Preferred antioxidants include tocopherol (vitamin E), tocopherol derivatives such as tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and/or its derivatives; erythorbic acid and its derivatives; sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, and cysteine hydrochloride.

Preferred reducing agents include thioglycolic acid, cysteine, cysteamine, etc.

Preferred oxidizing agents include hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate.

Preferred examples of preservatives, antibacterial agents, and disinfectants include hydroxybenzoic acid and its salts or esters such as methylparaben, ethylparaben, propylparaben, and butylparaben; salicylic acid; sodium benzoate; phenoxyethanol; isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; imidazolinium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, and quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzalkonium chloride, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, and hinokitiol; other phenols such as phenol, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, and sodium phenylphenol; phenylethyl alcohol, photosensitizers, antibacterial zeolites, and silver ions.

Preferred chelating agents include edetates (ethylenediaminetetraacetates) such as EDTA, EDTA 2Na, EDTA 3Na, and EDTA 4Na; hydroxyethylethylenediaminetriacetates such as EDTA 3Na; pentetates (diethylenetriaminepentaacetate); phytic acid; phosphonic acids such as etidronic acid and salts thereof such as their sodium salts; polyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine, gluconic acid, ascorbic acid, succinic acid, and tartaric acid.

Preferred examples of pH adjusters, acids, and alkalis include ascorbic acid, citric acid, sodium citrate, lactic acid, sodium lactate, potassium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, sodium hydroxide, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate.

Powder materials include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, lepidolite, biotite, vermiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate such as tricalcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, metal soaps (e.g., zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, Prussian blue, carbon black, titanium oxide, fine and ultrafine titanium oxide particles, zinc oxide, fine and ultrafine zinc oxide particles, alumina, silica, fumed silica (ultrafine silicic anhydrous particles), mica titanium Preferred examples include inorganic powders of various sizes and shapes, such as tan, fish scale foil, boron nitride, photochromic pigments, synthetic fluorine-containing phlogopite, fine particle composite powders, gold, silver, platinum, and aluminum, as well as inorganic powders that have been hydrophobized or hydrophilized by treating them with various surface treatment agents, such as silicones (e.g., hydrogen silicone and cyclic hydrogen silicone), other silanes, or titanium coupling agents; and organic powders of various sizes and shapes, such as starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene-acrylic acid copolymer resin powder, polyester powder, benzoguanamine resin powder, polyethylene terephthalate-polymethyl methacrylate laminate powder, polyethylene terephthalate-aluminum-epoxy laminate powder, urethane powder, silicone powder, and Teflon (registered trademark) powder, as well as surface-treated organic-inorganic composite powders.

Preferred inorganic salts include sodium chloride-containing salts such as table salt, regular salt, rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, and ammonium chloride; sodium sulfate, aluminum sulfate, aluminum-potassium sulfate (alum), aluminum-ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, and copper sulfate; sodium phosphates such as monosodium, disodium, and trisodium phosphate, potassium phosphates, calcium phosphates, and magnesium phosphates.

Ultraviolet absorbers include benzoic acid-based UV absorbers such as para-aminobenzoic acid, para-aminobenzoic acid monoglycerin ester, N,N-dipropoxypara-aminobenzoic acid ethyl ester, N,N-diethoxypara-aminobenzoic acid ethyl ester, N,N-dimethylpara-aminobenzoic acid ethyl ester, N,N-dimethylpara-aminobenzoic acid butyl ester, and N,N-dimethylpara-aminobenzoic acid methyl ester; anthranilic acid-based UV absorbers such as homomenthyl-N-acetylanthranilate; salicylic acid-based UV absorbers such as salicylic acid and its sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, and p-isopropanol phenyl salicylate; octyl cinnamate, ethyl-4-isopropyl cinnamate, and methyl-2,5-diisopropyl Cinnamic acid-based ultraviolet absorbers such as propyl cinnamate, ethyl 2,4-diisopropyl cinnamate, methyl 2,4-diisopropyl cinnamate, propyl p-methoxycinnamate, isopropyl p-methoxycinnamate, isoamyl p-methoxycinnamate, 2-ethylhexyl p-methoxycinnamate (octyl para-methoxycinnamate), 2-ethoxyethyl p-methoxycinnamate (cinoxate), cyclohexyl p-methoxycinnamate, ethyl α-cyano-β-phenylcinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocurine), glyceryl mono-2-ethylhexanoyl di-para-methoxycinnamate, ferulic acid and its derivatives; 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-di Benzophenone-based ultraviolet absorbers such as methoxybenzophenone, 2,2',4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, and 4-hydroxy-3-carboxybenzophenone; 3-(4'-methylbenzylidene)-d,l-camphor, 3-benzylidene-d,l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5-methylphenylbenzotriazole; 2-(2'-hydroxy-5'-t-octylphenyl)benzotriazole; Preferred examples include hydroxy-5'-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 5-(3,3-dimethyl-2-norbornylidene)-3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyl triazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate; hydantoin derivatives such as 2-(2'-hydroxy-5'-methylphenyl)benzotriazole, 1-(3,4-dimethoxyphenyl)-4,4-dimethyl-1,3-pentanedione, and 2-ethylhexyl dimethoxybenzylidene dioxoimidazolidinepropionate; phenylbenzimidazolazole sulfonic acid, terephthalylidene dicamphorsulfonic acid, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, and oryzanol and its derivatives.

Skin whitening agents include hydroquinone glycosides and their esters such as arbutin and α-arbutin; ascorbic acid, ascorbic acid phosphate salts such as sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate; ascorbic acid fatty acid esters such as ascorbic acid tetraisopalmitate; ascorbic acid alkyl ethers such as ascorbic acid ethyl ether; ascorbic acid glucosides and their fatty acid esters such as ascorbic acid-2-glucoside; ascorbic acid sulfate; and ascorbic acid derivatives such as tocopheryl ascorbyl phosphate. Preferred examples include ujic acid, ellagic acid, tranexamic acid and its derivatives, ferulic acid and its derivatives, placenta extract, glutathione, oryzanol, butylresorcinol, plant extracts such as oil-soluble chamomilla extract, oil-soluble licorice extract, Nishikawa willow extract, and saxifrage extract, 4-n-butylresorcinol (Rucinol), linoleic acid S (Linolec S), 4-methoxysalicylic acid potassium salt, adenosine phosphate disodium, 5,5'-dipropyl-biphenyl-2,2'-diol (magnolignan), dexpanthenol W, tranexamic acid cetyl hydrochloride, and rhododenol.

Vitamins and their derivatives include vitamin A such as retinol, retinol acetate, and retinol palmitate; B vitamins such as thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, flavin adenine dinucleotide, cyanocobalamin, folic acids, nicotinic acids such as nicotinamide and benzyl nicotinate, and cholines; vitamin C such as ascorbic acid and its sodium salts; vitamin D; vitamin E such as α-, β-, γ-, and δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt, etc. Preferred examples include ascorbic acid phosphate salts, ascorbic acid fatty acid esters such as ascorbic acid tetraisopalmitate, ascorbyl stearate, ascorbyl palmitate, and ascorbyl dipalmitate; ascorbic acid alkyl ethers such as ascorbic acid ethyl ether; ascorbic acid glucosides and fatty acid esters thereof such as ascorbic acid-2-glucoside; ascorbic acid derivatives such as tocopheryl ascorbyl phosphate; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol linoleate, tocopherol ferulate, and tocopherol phosphate; tocotrienols; and various other vitamin derivatives.

Hair growth medications, blood circulation promoters, and stimulants include plant extracts and tinctures such as Swertia japonica extract, capsicum tincture, ginger tincture, ginger extract, and cantharis tincture; capsaicin, nonylic acid vanillylamide, zingerone, ichthammol, tannic acid, borneol, cyclandelate, cinnarizine, tolazoline, acetylcholine, verapamil, cepharanthine, γ-oryzanol, vitamin E and its derivatives such as tocopherol nicotinate and tocopherol acetate, nicotinic acid, and nicotinamide (niacin). Preferred examples include nicotinic acid derivatives such as benzophenone amide, nicotinic acid benzyl ester, inositol hexanicotinate, and nicotinic alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, flavanonol derivatives, stigmasterol or stigmastanol and glycosides thereof, minoxidil, the ALK5 inhibitor compounds described in WO 2005/085241, and the WNT-5 inhibitor compounds described in WO 2003/086334.

Preferred examples of agents for preventing gray hair include watercress, soapberry, saxifrage, and thyme.

Preferred hormones include estradiol, estrone, ethinylestradiol, cortisone, hydrocortisone, and prednisone.

Other medicinal agents such as anti-wrinkle agents, anti-aging agents, firming agents, cooling agents, warming agents, wound healing promoters, irritation soothing agents, analgesics, and cell activators include retinols, retinoic acids, tocopheryl retinoate; lactic acid, glycolic acid, gluconic acid, fruit acids, salicylic acid and their derivatives such as glycosides and esters, hydroxycapric acid, long-chain alpha-hydroxy fatty acids, long-chain alpha-hydroxy fatty acid cholesteryl and other alpha- or beta-hydroxy acids and their derivatives; gamma-aminobutyric acid, gamma-amino-beta-hydroxybutyric acid; carnitine; carnosine; creatine; ceramides; sphingosines; caffeine, xanthine, and their derivatives; coenzyme Q10, carotene, lycopene, astaxanthin, lutein, alpha-lipoic acid, white Preferred examples include antioxidants/active oxygen scavengers such as gold nanocolloids and fullerenes; catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamin, protoanthocyanidin, chlorogenic acid, and apple polyphenols; rutin and its derivatives; hesperidin and its derivatives; lignan glycosides; licorice extract-related substances such as glabridin, glabrene, liquiritin, and isoliquiritin; lactoferrin; shogaol, gingerol; fragrance substances and their derivatives such as menthol and cedrol; capsaicin, vanillin, and derivatives thereof; insect repellents such as diethyltoluamide; and complexes of physiologically active substances and cyclodextrins.

Plant, animal and microbial extracts include iris extract, angelica extract, asparagus extract, avocado extract, hydrangea extract, almond extract, althea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo extract, chinko extract, fennel extract, turmeric extract, oolong tea extract, uva ursi extract, angelica tree extract, echinacea leaf extract, enmeiso extract, scutellaria root extract, and oak extract. Ubaku extract, Coptis japonica extract, Barley extract, Panax ginseng extract, St. John's wort extract, Lamium extract, Ononis extract, Netherlands mustard extract, Orange extract, Dried seawater, Seaweed extract, Persimmon leaf extract, Kakyoku extract, Hydrolyzed elastin, Hydrolyzed wheat powder, Hydrolyzed silk, Pueraria lobata extract, Chamomilla recutita extract, Oil-soluble Chamomilla extract, Carrot extract, Artemisia capillaris extract, Oat extract, Karcade extract, Licorice extract, Oil-soluble licorice extract, kiwi extract, bell extract, wood ear extract, cinchona extract, cucumber extract, Paulownia leaf extract, guanosine, guava extract, kudzu extract, gardenia extract, kumazasa extract, sophora extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, mulberry extract, gentian extract, geranium extract, black tea extract, yeast extract, magnolia bark extract, Coffee extract, burdock extract, rice extract, fermented rice extract, fermented rice bran extract, rice germ oil, comfrey extract, collagen, bilberry extract, Chinese rhizome extract, Bupleurum extract, umbilical cord extract, saffron extract, salvia extract, soapwort extract, bamboo extract, hawthorn extract, Japanese sanshou extract, Japanese pepper extract, shiitake mushroom extract, rehmannia root extract, lithospermum root extract, perilla extract, linden extract, meadowsweet extract, jatoba extract, peony Extract, Angelica Root Extract, Calamus Root Extract, Birch Extract, White Fungus Extract, Horsetail Extract, Stevia Extract, Stevia Fermented Product, Nishikawa Willow Extract, Ivy Extract, Hawthorn Extract, Elderberry Extract, Yarrow Extract, Peppermint Extract, Sage Extract, Mallow Extract, Cnidium Extract, Swertia Root Extract, Soybean Extract, Thyme Extract, Poppopo extract, lichen extract, tea extract, clove extract, Imperata cylindrica extract, tangerine extract, tea tree oil, sweet tea extract, chili pepper extract, angelica extract, calendula extract, peach kernel extract, spruce extract, Houttuynia cordata extract, tomato extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, burdock extract, lotus extract, parsley extract, birch extract, honey, witch hazel extract, parietaria extract, burdock extract Preferred examples of extracts include okoshi extract, bisabolol, cypress extract, bifidobacterium extract, loquat extract, coltsfoot extract, butterbur stalk extract, poria cocos extract, butcher's broom extract, grape extract, grape seed extract, propolis, loofah extract, safflower extract, peppermint extract, linden extract, peony extract, hop extract, myocarpus extract, pine extract, horse chestnut extract, skunk cabbage extract, soapberry extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, saxifrage extract, yuzu extract, lily extract, coix seed extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, lychee extract, lettuce extract, lemon extract, forsythia extract, astragalus extract, rose extract, rosemary extract, Roman chamomile extract, royal jelly extract, and burnet extract.

Antipruritics include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, and substance P inhibitors.

Keratin exfoliating and dissolving agents include salicylic acid, sulfur, resorcinol, selenium sulfide, and pyridoxine.

Antiperspirants include aluminum chlorohydrate, aluminum chloride, zinc oxide, and zinc paraphenolsulfonate.

Cooling agents include menthol and methyl salicylate.

Astringents include citric acid, tartaric acid, lactic acid, aluminum potassium sulfate, and tannic acid.

Enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, etc.

Preferred examples of nucleic acids include ribonucleic acid and its salts, deoxyribonucleic acid and its salts, and adenosine triphosphate disodium.

Fragrances: acetyl cedrene, amyl cinnamaldehyde, allyl amyl glycolate, beta-ionone, isoe super, isobutylquinoline, iris oil, iron, indole, ylang-ylang oil, undecanal, undecenal, gamma-undecalactone, estragole, eugenol, oakmoss, opoponax resinoid, orange oil, eugenol, auranthiol, galacsolids, carvacrol, L-carvone, camphor, cannon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile, isobornyl acetate , Geranyl acetate, Dimethylbenzylcarbinyl acetate, Styrallyl acetate, Cedryl acetate, Terpinel acetate, p-t-butylcyclohexyl acetate, Vetiveryl acetate, Benzyl acetate, Linalyl acetate, Isopentyl salicylate, Benzyl salicylate, Sandalwood oil, Santalol, Cyclamen aldehyde, Cyclopentadecanolide, Methyl dihydrojasmonate, Dihydromyrcenol, Jasmine absolute, Jasmine lactone, cis-Jasmone, Citral, Citronenol, Citronellal, Cinnamon bark oil, 1,8-cineole, Cinnamaldehyde, Su Chillax resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascone, damascenone, thymol, tuberose absolute, decanal, decalactone, terpineol, gamma-terpinene, triplal, nerol, nonanal, 2,6-nonadienol, nonalactone, patchouli alcohol, vanilla absolute, vanillin, basil oil, patchouli oil, hydroxycitronellal, alpha-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitgrain oil, hexyl cinnamaldehyde, cis-3-hexenoic acid Preferred examples include synthetic and natural fragrances such as balsam of Peru, vetiver oil, vetiverol, peppermint oil, pepper oil, heliotropin, bergamot oil, benzyl benzoate, borneol, myrrh resinoid, musk ketone, methylnonylacetaldehyde, γ-methylionone, menthol, L-menthol, L-menthone, eucalyptus oil, β-ionone, lime oil, lavender oil, D-limonene, linalool, lyral, lilial, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, and various essential oils, as well as various blended fragrances.

Pigments, colorants and dyes include Brown No. 201, Black No. 401, Purple No. 201, Purple No. 401, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 202, Blue No. 203, Blue No. 204, Blue No. 205, Blue No. 403, Blue No. 404, Green No. 201, Green No. 202, Green No. 204, Green No. 205, Green No. 3, Green No. 401, Green No. 402, Red No. 102, Red No. 104-1, Red No. 105-1, Red No. 106, Red No. 2, Red No. 201, Red No. 202, Red No. 203, Red No. 204, Red No. 205, Red No. 206, Red No. 207, Red No. 208, Red No. 213, Red No. 214, Red No. 215, Red No. 218, Red No. 219, Red No. 220, Red No. 221, Red No. 223, Red No. 225, Red No. 226, Red No. 227, Red No. 228, Red No. 230-1, Red No. 230-2, Red No. 231, Red No. 232, Red No. 3, Red No. 401, Red No. 404, Red No. 405, Red No. 501, Red No. 502, Red No. 503, Red No. 504, Red No. 505, Red No. 506, Orange No. 201, Orange No. 203, Orange No. 204, Orange No. 205, Orange No. 206, Orange No. 207, Orange No. 401, Orange No. 402, Orange No. 403, Yellow No. 201, Yellow No. 202-1, Yellow No. 202-2, Yellow No. 203, Yellow Color No. 204, Yellow No. 205, Yellow No. 4, Yellow No. 401, Yellow No. 402, Yellow No. 403-1, Yellow No. 404, Yellow No. 405, Yellow No. 406, Yellow No. 407, Yellow No. 5, etc. Legal dyes; other acid dyes such as Acid Red 14; basic dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, and Arianor Straw Yellow; nitro dyes such as HC Yellow 2, HC Yellow 5, HC Red 3, 4-hydroxypropylamino-3-nitrophenol, N,N'-bis(2-hydroxyethyl)-2-nitro-p-phenylenediamine, HC Blue 2, and Basic Blue 26; disperse dyes; anthraquinones such as astaxanthin and alizarin, and anthocyanins. Preferred examples include natural pigments and dyes such as naphthoquinones (e.g., ginseng, beta-carotene, catenal, capsanthin, chalcone, carthamine, quercetin, crocin, chlorophyll, curcumin, cochineal, shikonin), bixin, flavones, betacyanidin, henna, hemoglobin, lycopene, riboflavin, and rutin; oxidation dye intermediates and couplers (e.g., p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcinol, 1-naphthol, 2,6-diaminopyridine, and salts thereof); autoxidation dyes (e.g., indoline); and dihydroxyacetone.

Preferred examples of anti-inflammatory agents include glycyrrhizinic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, ketoprofen, ibuprofen, diclofenac, loxoprofen, celecoxib, infliximab, etanercept, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; and plant extracts such as peach leaf extract and mugwort leaf extract.

Preferred examples of anti-asthmatic agents, anti-chronic obstructive pulmonary disease agents, anti-allergic agents, and immunomodulators include aminophylline, theophyllines, steroids (fluticasone, beclomethasone, etc.), leukotriene antagonists, thromboxane inhibitors, intal, beta-2 agonists (formoterol, salmeterol, albuterol, tulobuterol, clenbuterol, epinephrine, etc.), tiotropium, ipratropium, dextromethorphan, dimemorfan, bromhexine, tranilast, ketotifen, azelastine, cetirizine, chlorpheniramine, mequitazine, tacrolimus, cyclosporine, sirolimus, methotrexate, cytokine regulators, interferon, omalizumab, and protein/antibody preparations.

Preferred examples of anti-infective and anti-fungal agents include oseltamivir, zanamivir, and itraconazole. In addition to these, known cosmetic ingredients, pharmaceutical ingredients, and food ingredients can be included in known combinations, ratios, and amounts, such as ingredients listed in the Cosmetic Ingredient Standards, Cosmetic Ingredient Standards by Type, Japan Cosmetic Industry Association Ingredient Labeling List, INCI Dictionary (The International Cosmetic Ingredient Dictionary and Handbook), Quasi-drug Ingredient Standards, Japanese Pharmacopoeia, Pharmaceutical Additive Standards, and Food Additives Official Standards, as well as ingredients listed in Japanese and foreign patent gazettes and patent publications (including published gazettes and republications) classified under the International Patent Classification IPC A61K7 and A61K8.

The composition of the present invention may be in any form as long as it can form a film (layer) on the skin or hair surface.
Examples of such emulsions include oil-in-water (O/W), water-in-oil (W/O), W/O/W, and O/W/O, as well as oil-based, solid, liquid, paste, stick, volatile oil, powder, jelly, gel, paste, emulsified polymer, sheet, mist, and spray. The product form may also be any, and the product may be used as a dispersion, emulsion, cream, pack, spray, gel, or the like.
The above composition can be blended with various ingredients known to those skilled in the art to achieve the dosage form or product shape according to the dosage form or product shape.
In the above composition, when the content of the lipid peptide type compound is, for example, 0.0001% by mass or more and 0.5% by mass or less relative to the total mass of the composition, the above composition can be used as a cosmetic, particularly a hair cosmetic.

[Content of lipid peptide type compound in composition]
When the content of the lipid peptide compound relative to the total mass of the composition of the present invention is 1.0 mass% or more and 20.0 mass% or less, preferably 1.0 mass% or more and 10.0 mass% or less, and more preferably 4.0 mass% or more and 6.0 mass% or less, the composition of the present invention becomes a white solid at room temperature and can be stored at room temperature. Furthermore, when the breaking strength (breaking stress) is, for example, 1.0 to 5.0 × 10 ⁵ Pa, preferably 2.0 to 4.0 × 10 ⁵ Pa, and more preferably 2.0 to 3.0 × 10 ⁵ Pa, the composition is less likely to crumble and is excellent in transportation, storage, etc.
The breaking strength can be measured using, for example, a YAMADEN RHEONER II CREEP METER RE2-33005B (Yamaden Co., Ltd.) at a measurement speed of 1 mm/sec, a measurement strain rate of 80%, a storage pitch of 0.10 sec, and a jig number 30349-3.
When the content of the lipid peptide-type compound in the composition of the present invention is within the above range, the content of the sucrose ester is 0.5% by mass or more and 10.0% by mass or less, preferably 0.5% by mass or more and 5.0% by mass or less, and more preferably 2.0% by mass or more and 3.0% by mass or less, relative to the total mass of the composition of the present invention.
When the content of the lipid peptide compound in the composition of the present invention is within the above range, the content of the 1,2-alkanediol is 1.4% by mass or more and 28.0% by mass or less, preferably 1.4% by mass or more and 14.0% by mass or less, and more preferably 5.6% by mass or more and 8.4% by mass or less, relative to the total mass of the composition of the present invention.
When the content of the lipid peptide type compound in the composition of the present invention is within the above range, the content of the fatty acid is 0.1% by mass or more and 2.0% by mass or less, preferably 0.1% by mass or more and 1.0% by mass or less, and more preferably 0.4% by mass or more and 0.6% by mass or less, relative to the total mass of the composition of the present invention.
When the content of the lipid peptide-type compound of the present invention is within the above range, the water content is 40.0% by mass or more and 97.0% by mass or less, preferably 70.0% by mass or more and 97.0% by mass or less, and more preferably 82.0% by mass or more and 88.0% by mass or less.

Furthermore, when the composition of the present invention is further diluted with water, the content of the lipid peptide type compound relative to the total mass of the composition is 0.0001% by mass or more and 0.5% by mass or less, preferably 0.0001% by mass or more and 0.2% by mass or less, more preferably 0.001% by mass or more and 0.05% by mass or less, even more preferably 0.005% by mass or more and 0.05% by mass or less, or preferably 0.001% by mass or more and 0.5% by mass or less, more preferably 0.005% by mass or more and 0.25% by mass or less, even more preferably 0.01% by mass or more and 0.25% by mass or less, and the lipid peptide type compound is uniformly dispersed in the liquid without causing precipitation or sedimentation over time at low temperatures or room temperature, and the composition of the present invention becomes a transparent dispersion liquid with high dispersion stability.
In the present invention, low temperature refers to a temperature lower than room temperature, and refers to a temperature of 0°C or higher and lower than 15°C, or 4°C or higher and lower than 15°C, and room temperature refers to a temperature of 15°C or higher and lower than 40°C, or 15°C or higher and lower than 30°C.
When the content of the lipid peptide compound in the composition of the present invention is within the above range, the content of the sucrose ester is, relative to the total mass of the composition of the present invention, 0.00005% by mass or more and 0.25% by mass or less, preferably 0.00005% by mass or more and 0.1% by mass or less, more preferably 0.0005% by mass or more and 0.025% by mass or less, even more preferably 0.0025% by mass or more and 0.025% by mass or less, or preferably 0.0005% by mass or more and 0.25% by mass or less, more preferably 0.0025% by mass or more and 0.125% by mass or less, even more preferably 0.005% by mass or more and 0.125% by mass or less.
When the content of the lipid peptide compound in the composition of the present invention is within the above range, the content of the 1,2-alkanediol is, relative to the total mass of the composition of the present invention, 0.00014% by mass or more and 0.7% by mass or less, preferably 0.00014% by mass or more and 0.28% by mass or less, more preferably 0.0014% by mass or more and 0.07% by mass or less, even more preferably 0.007% by mass or more and 0.07% by mass or less, or preferably 0.0014% by mass or more and 0.7% by mass or less, more preferably 0.007% by mass or more and 0.35% by mass or less, even more preferably 0.014% by mass or more and 0.35% by mass or less.
When the content of the lipid peptide type compound in the composition of the present invention is within the above range, the content of the fatty acid is, relative to the total mass of the composition of the present invention, 0.00001% by mass or more and 0.05% by mass or less, preferably 0.00001% by mass or more and 0.02% by mass or less, more preferably 0.0001% by mass or more and 0.005% by mass or less, even more preferably 0.0005% by mass or more and 0.005% by mass or less, or preferably 0.0001% by mass or more and 0.05% by mass or less, more preferably 0.0005% by mass or more and 0.025% by mass or less, even more preferably 0.001% by mass or more and 0.025% by mass or less.
Because the composition of the present invention, which is a dispersion, has high dispersion stability, even if the composition of the present invention is further diluted or directly mixed with other ingredients to produce a product in a subsequent process, the final product will have no variation in quality and can be mixed evenly.

[Method of producing the composition]
The composition of the present invention can be produced, for example, by mixing at least one lipid peptide compound, a sucrose ester, a 1,2-alkanediol, water, a fatty acid, and other additives, stirring the mixture at room temperature or under heat, and then allowing the mixture to cool to about room temperature.
The heating and stirring temperature is not particularly limited as long as the components can be mixed uniformly. For example, the stirring temperature can be 0°C to 90°C, 30°C to 90°C, e.g., 20°C, 30°C, 50°C, or 80°C, and the stirring time can be appropriately selected, for example, from 5 minutes to 3 hours.

[Method of producing lipid peptide dispersion]
When the amount of the lipid peptide compound blended is 1.0% by mass or more and 20.0% by mass or less relative to the total mass of the composition of the present invention, the composition of the present invention becomes a white solid at room temperature.
In addition, when the white solid composition of the present invention is mixed with water and stirred at room temperature or heated, the composition of the present invention becomes a transparent liquid with high dispersion stability at low or room temperature.In this case, the amount of lipid peptide compound is 0.0001% by mass or more and 0.5% by mass or less relative to the total mass of the composition.The liquid composition of the present invention is also called lipid peptide dispersion.It is in a stable dispersion state at low or room temperature, can be mixed evenly without heating when used, and is easy to handle.
The lipid peptide dispersion liquid may be stored at room temperature or at a low temperature. The amount of the lipid peptide dispersion liquid is preferably 0.0001% by mass or more and 0.2% by mass or less, more preferably 0.005% by mass or more and 0.5% by mass or less, and most preferably 0.01% by mass or more and 0.1% by mass or less, relative to the total mass of the composition.

[Method of manufacturing cosmetics]
The composition (white solid) stored at room temperature or low temperature can be heated and dissolved, and mixed with various solvents and other additives and stirred to produce a cosmetic that is solid at room temperature.
The composition (dispersion) stored at room temperature or low temperature can be mixed with water, various solvents, and other additives with or without heating, and stirred at room temperature or low temperature to produce a cosmetic preparation.
In this case, the amount of the lipid peptide compound blended is 0.0001% by mass or more and 5.0% by mass or less, preferably 0.0001% by mass or more and 0.5% by mass or less, and more preferably 0.0001% by mass or more and 0.25% by mass or less, relative to the total mass of the cosmetic. There are no particular restrictions on whether the cosmetic is solid or liquid.
The blending amount of the sucrose ester is, for example, 0.001 to 20% by mass, preferably 0.005 to 10.0% by mass, more preferably 0.01 to 10.0% by mass, even more preferably 0.05 to 5.0% by mass, and particularly preferably 0.1 to 5.0% by mass, relative to the total mass of the cosmetic.
The blending amount of the 1,2-alkanediol is, for example, 0.001 to 60% by mass, preferably 0.001 to 30% by mass, and more preferably 0.01 to 10% by mass, relative to the total mass of the cosmetic.
The amount of the fatty acid to be blended is, for example, 0.0001 to 10.0% by mass, preferably 0.005 to 5.0% by mass, and more preferably 0.01 to 1.0% by mass, relative to the total mass of the cosmetic.

In the present invention, the term "transparent" refers to a state in which no precipitates are visible in the composition when visually inspected. Alternatively, the transparency of a composition can be determined by evaluating the turbidity or transmittance using a turbidity meter or spectrophotometer, etc.

The present invention will be explained in detail below using Examples 1-15 and Comparative Examples 1-4, but the present invention is not limited to these examples.

[Synthesis Example 1: Synthesis of lipid peptide (N-palmitoyl-Gly-His)]
In this example, the lipid peptide used as the gelling agent was synthesized by the method described below.
A 500 mL four-neck flask was charged with 14.2 g (91.6 mmol) of histidine, 30.0 g (91.6 mmol) of N-palmitoyl-Gly-methyl, and 300 g of toluene. 35.3 g (183.2 mmol) of a 28% methanol solution of sodium methoxide (a base) was added, and the mixture was heated to 60°C in an oil bath and stirred for 1 hour. The oil bath was then removed, the mixture was allowed to cool to 25°C, and the solution was reprecipitated with 600 g of acetone and collected by filtration. The resulting solid was dissolved in a mixed solution of 600 g of water and 750 g of methanol, and 30.5 ml (183.2 mmol) of 6 N hydrochloric acid was added to neutralize the solution, resulting in the precipitation of a solid, which was then filtered. The resulting solid was then dissolved in a mixed solution of 120 g of tetrahydrofuran and 30 g of water at 60°C. 150 g of ethyl acetate was added, and the mixture was cooled from 60°C to 30°C. The precipitated solid was then filtered. The resulting solid was dissolved in 120 g of tetrahydrofuran and 60 g of acetonitrile, heated to 60°C, stirred for 1 hour, cooled, and filtered. The resulting solid was washed with 120 g of water, filtered, and dried under reduced pressure to obtain 26.9 g (yield 65%) of white crystals of N-palmitoyl-Gly-His free form (hereinafter, also simply referred to as Pal-GH).

[Preparation Examples 1 to 15, Comparative Preparation Examples 1 to 4: Preparation of Pal-GH Compositions Using Various Sucrose Esters]
Pal-GH obtained in Synthesis Example 1 above, 1,2-alkanediol, sucrose ester or surfactant, fatty acid, and purified water were weighed out to give the composition (mass: g) shown in Table 1 and placed in a 200 mL beaker (manufactured by HARIO Corporation), and the mixture was heated and stirred at 200 rpm for 30 minutes in a water bath set at a temperature of about 80°C, thereby obtaining a Pal-GH composition.

Comparative Preparation Examples 5 to 7: Preparation of Pal-GH Compositions
Pal-GH obtained in Synthesis Example 1 above, 1,2-alkanediol, sucrose ester or surfactant, fatty acid, and purified water were weighed out to give the composition (mass: g) shown in Table 2 and placed in a 200 mL beaker (manufactured by HARIO Corporation), and the mixture was heated and stirred at 200 rpm for 30 minutes in a water bath set at a temperature of about 80°C, thereby obtaining a Pal-GH composition.

[Examples 1 to 15 and Comparative Examples 1 to 4: Preparation of aqueous dispersions of Pal-GH compositions]
The Pal-GH compositions obtained in Preparation Examples 1 to 15 and Comparative Preparation Examples 1 to 4 above and water were weighed, and the Pal-GH compositions were added to the stirred water in a 200 mL beaker (manufactured by HARIO Corporation). The mixture was stirred at 200 rpm for 5 minutes, and then allowed to stand at 25°C or cooled to 4°C, thereby diluting the composition 200-fold or 1000-fold with water to prepare aqueous dispersions of the Pal-GH compositions (also referred to as Pal-GH aqueous dispersions) shown in Tables 3 and 4.
The prepared Pal-GH aqueous dispersions were visually evaluated with the following criteria: O: Pal-GH was uniformly dispersed in water (no precipitation or aggregation occurred), △: Pal-GH was uniformly dispersed in water but became non-uniform after a few days, and ×: Pal-GH was non-uniformly dispersed in water (precipitation or aggregation occurred). The results are shown in Tables 3 and 4.

[Example 5, Comparative Examples 4, 5, and 7: Preparation of aqueous dispersions of Pal-GH compositions]
The Pal-GH compositions and water obtained in Preparation Example 5 and Comparative Preparation Examples 4, 5, and 7 above were weighed, and the Pal-GH compositions were added to the stirred water in a 200 mL beaker (manufactured by HARIO Corporation). The mixture was stirred for 5 minutes at 200 rpm and allowed to stand at room temperature to dilute the mixture 20-fold or 1000-fold with water to prepare aqueous dispersions of the Pal-GH compositions (also referred to as Pal-GH aqueous dispersions) shown in Table 5. These were stored at 4°C or 25°C to compare their stability.
The prepared Pal-GH aqueous dispersions were visually evaluated with the following criteria: O: Pal-GH was uniformly dispersed in water (no precipitation or aggregation occurred), △: Pal-GH was uniformly dispersed in water but became non-uniform after a few days, and ×: Pal-GH was non-uniformly dispersed in water (precipitation or aggregation occurred). The results are also shown in Table 5.

[Example 5, Comparative Examples 4 and 5: Preparation of aqueous dispersion of Pal-GH composition]
The Pal-GH compositions and water obtained in Preparation Example 5, Comparative Preparation Example 4, and Comparative Preparation Example 5 were weighed, and the Pal-GH compositions were added to the stirred water in a 200 mL beaker (manufactured by HARIO Corporation). The mixture was stirred at 200 rpm for 5 minutes and allowed to stand at room temperature to dilute the composition with water to a Pal-GH concentration of 0.25%, thereby preparing aqueous dispersions of the Pal-GH composition (also referred to as Pal-GH aqueous dispersions). These were stored at 25°C and compared for stability. The results are shown in FIG. 21.
As shown in Figure 21, Pal-GH was uniformly dispersed in water in Example 5 (diluted solution of Preparation Example 5), whereas Pal-GH was observed to precipitate or aggregate in water in Comparative Example 4 (diluted solution of Comparative Preparation Example 4) and Comparative Example 5 (diluted solution of Comparative Preparation Example 5).

Example 1: Skin penetration enhancing effect of the active ingredient (nicotinamide: NA) of a lipid peptide composition
A human three-dimensional cultured epidermal model (LabCyte EPI-MODEL24, φ6.4 mm, lot number #LCE12-200706-A, manufactured by Japan Tissue Engineering Co., Ltd.) was placed in a 24-well tissue culture plate (IWAKI, manufactured by Asahi Glass Co., Ltd.), and 1 mL of phosphate-buffered saline (pH 7.4) (PBS) was dispensed into each well, which served as the reservoir solution. On the donor side, Pal-GH aqueous dispersions of Example 1 were prepared with Pal-GH concentrations of 0.001% by mass, 0.0025% by mass, and 0.005% by mass, respectively, from Preparation Example 1. Nicotinamide (Sigma Aldrich) was added to each Pal-GH aqueous dispersion to achieve a 1% by mass concentration. For comparison, a 1% by mass nicotinamide aqueous solution (NA water only) was also prepared. A skin permeability test was performed by adding 200 μL of each preparation solution, covering the tissue culture plate with a lid, and allowing it to stand in an incubator at 37 °C. After 4 hours of permeation from the addition of each preparation solution, the reservoir solution and three-dimensional cultured epidermal model were collected. The collected three-dimensional cultured epidermal model was washed three times with 500 μL of PBS, cut into four equal parts with a scalpel, and placed in a 1.5 mL microtube (manufactured by Eppendorf). Nicotinamide was then extracted from the three-dimensional cultured epidermal model by adding 750 μL of a 1/1 v/v methanol/purified water extract and treating with a vortex mixer (manufactured by Kenis Co., Ltd.) for 1 hour, and then filtered through a 0.45 μm pore size syringe filter (manufactured by Merck). The nicotinamide concentration in the resulting filtrate and reservoir solution was measured by high-performance liquid chromatography (HPLC, manufactured by Agilent), and the amount of nicotinamide permeated through the skin per unit area was calculated. The test was carried out three times for each sample, and the average value was calculated, from which the amount of skin permeation after 3 hours was calculated. The HPLC measurement conditions were as follows:
Detector: ultraviolet absorption photometer (measurement wavelength: 260 nm), column: stainless steel column with an inner diameter of 4.6 mm and a length of 25 cm packed with 3 μm octadecylsilylated silica gel for HPLC (ODS-4, GL Sciences Inc.), column temperature: 40°C, mobile phase: 0.1% aqueous acetic acid/5 mM aqueous ICP-ALKS7:methanol=9:1 (v/v)

The results obtained are shown in Figures 1 and 2. Figure 1 shows the amount of nicotinamide permeation extracted from the three-dimensional cultured epidermal model, and Figure 2 shows the amount of nicotinamide permeation detected in the reservoir. The preparation solution of Example 1 showed a higher amount of nicotinamide permeation at all concentrations than when only a 1% by mass aqueous nicotinamide solution was added.

[Examples 3 to 5: Skin penetration enhancing effect of the active ingredient (nicotinamide) of the lipid peptide composition]
Pal-GH aqueous dispersions of Examples 3 to 5 were prepared, each having a Pal-GH concentration of 0.025% by mass from Preparation Example 3, and 0.005% by mass and 0.025% by mass from Preparation Examples 4 and 5. Nicotinamide (Sigma Aldrich) was added to each Pal-GH aqueous dispersion to a concentration of 1% by mass. For comparison, a 1% by mass nicotinamide aqueous solution (NA water only) was also prepared. Following the same procedure as above, 200 μL of each preparation was added to each plate, which was then covered with a tissue culture plate lid and allowed to stand in an incubator at 37°C, whereupon a skin permeability test was performed.

The results obtained are shown in Figures 3 and 4. Figure 3 shows the amount of nicotinamide permeation extracted from the three-dimensional cultured epidermal model, and Figure 4 shows the amount of nicotinamide permeation detected in the reservoir. The preparations of Examples 3 to 5 showed higher amounts of nicotinamide permeation at all concentrations compared to when only a 1% by mass aqueous nicotinamide solution was added.

[Examples 6 to 11: Skin penetration enhancing effect of the active ingredient (nicotinamide) of the lipid peptide composition]
Pal-GH aqueous dispersions of Examples 6 to 10, each with a Pal-GH concentration of 0.025% by mass, were prepared from Preparation Examples 6 to 10, and Pal-GH aqueous dispersions of Examples 11 to 11, each with a Pal-GH concentration of 0.05% by mass, were prepared. Nicotinamide (Sigma Aldrich) was added to each Pal-GH aqueous dispersion to a concentration of 1% by mass. For comparison, a 1% by mass nicotinamide aqueous solution (NA water only) was also prepared. Following the same procedure as above, 200 μL of each preparation was added to a tissue culture plate, which was then covered with a lid and allowed to stand in an incubator at 37°C, whereupon a skin permeability test was performed.

The results are shown in Figures 5 and 6. Figure 5 shows the amount of nicotinamide permeation extracted from the three-dimensional cultured epidermal model, and Figure 6 shows the amount of nicotinamide permeation detected in the reservoir. The 0.025% by mass Pal-GH preparations of Examples 6 to 10 and the 0.05% by mass Pal-GH preparation of Example 11 showed a higher amount of nicotinamide permeation than when only a 1% by mass nicotinamide aqueous solution was added.

[Examples 11 to 14: Skin penetration enhancing effect of the active ingredient (nicotinamide) of the lipid peptide composition]
Pal-GH aqueous dispersions of Examples 11 to 14 were prepared, each with a Pal-GH concentration of 0.05% by mass, from Preparation Examples 11 to 14. Nicotinamide (Sigma Aldrich) was added to each Pal-GH aqueous dispersion to a concentration of 1% by mass. For comparison, a 1% by mass nicotinamide aqueous solution (NA water only) was also prepared. Following the same procedure as above, 200 μL of each preparation was added to each plate, which was then covered with a tissue culture plate lid and allowed to stand in an incubator at 37°C, whereupon a skin permeability test was performed.

The results obtained are shown in Figures 7 and 8. Figure 7 shows the amount of nicotinamide permeation extracted from the three-dimensional cultured epidermal model, and Figure 8 shows the amount of nicotinamide permeation detected in the reservoir. The 0.05% by mass Pal-GH preparations of Examples 11 to 14 showed a higher amount of nicotinamide permeation than when a 1% by mass aqueous nicotinamide solution was added.

[Examples 11 to 14: Confirmation of membrane formation of lipid peptide compositions]
Artificial leather Sapler (manufactured by Idemitsu Technofine Co., Ltd.) was cut into 4 cm squares, and 1.0 mL of each of the 0.05 mass % Pal-GH aqueous dispersions prepared in Examples 11 to 14 above was applied, followed by drying for 1 hour in a thermostatic chamber at 32°C. The surface of each dried film was observed using a Schottky field emission scanning electron microscope JSM-7800F (manufactured by JEOL Ltd.). Carbon tape was used to secure the samples, and measurements were taken at an acceleration voltage of 0.7 kV. The results are shown in Figure 9. It was confirmed that all of the dried films from Examples 11 to 14 formed fibrous films.

[Examples 11 to 14: Lipid peptide composition inhibits adhesion of PM2.5 particles]
Artificial leather (Supplare, manufactured by Idemitsu Technofine Co., Ltd.) was cut into 4 cm squares and coated with 1.0 mL of each of the 0.05 wt% Pal-GH aqueous dispersions prepared in Examples 11 to 14, or purified water for comparison, followed by drying for 1 hour in a thermostatic chamber at 32°C. 1.5 g of PM2.5 particles (NIES-CRM No. urban airborne particulate matter) was placed in a 4 cm square weighing dish. Each of the prepared Suplare was brought into contact with the PM2.5 particles, pressed with tweezers 10 times, and then shaken for 10 seconds to remove excess PM2.5 particles. The PM2.5 particles attached to each Suplare were then photographed and observed. The results are shown in Figure 10. It was confirmed that the Suplare coated with the 0.05 wt% Pal-GH aqueous dispersions of Examples 11 to 14 inhibited the adhesion of PM2.5 particles.

[Examples 3 and 5: Measurement of moisture adsorption and desorption of hair treated with lipid peptide composition]
30 mL of the Pal-GH aqueous dispersions of Examples 3 and 5, each containing 0.025% by mass of Pal-GH, was prepared. A strand (approximately 10 cm, approximately 1 g) of damaged hair (also referred to as bleached hair) that had been bleached three times was immersed in the dispersion and allowed to stand for 30 minutes. The hair was then rinsed with water, towel-dried, and then dried overnight in a constant-temperature bath at 50°C. The resulting hair-treated samples were sheared to 1 cm lengths, and the moisture adsorption and desorption amounts of each hair weighed at 100 mg were evaluated using a DVS Adventure dynamic moisture adsorption and desorption analyzer. The hair was dried at 0% relative humidity for two days, and then the humidity was suddenly increased to 90% relative humidity, at which point the change in mass (% by mass) was measured. The above procedure was performed automatically using a program. The results are shown in Figure 11. It was confirmed that compared to damaged hair not treated with the lipid peptide solution, damaged hair treated with the 0.025% by mass Pal-GH aqueous dispersion of each of Examples 3 and 5 had reduced moisture adsorption.

Example 10: Measurement of moisture adsorption and desorption of hair treated with lipid peptide composition
30 mL of the Pal-GH aqueous dispersions of Example 10, each with a Pal-GH concentration of 0.005% by mass and 0.025% by mass, were prepared from Preparation Example 10. Sodium dodecyl sulfate (SDS, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) was added to the dispersion to a concentration of 1% by mass. A strand of damaged hair (approximately 10 cm, approximately 1 g) that had been bleached three times was immersed in the dispersion and allowed to stand for 30 minutes. The resulting hair-treated samples were then washed with water, towel-dried, and then dried overnight in a constant-temperature oven at 50°C. The moisture adsorption and desorption amounts of each hair sample were evaluated using a DVS Adventure dynamic moisture adsorption and desorption analyzer. The hair was dried at 0% relative humidity for two days, and the humidity was then suddenly increased to 90% relative humidity, at which point the change in mass (% by mass) was measured. The above procedure was performed automatically using a program. The results are shown in Figure 12. It was confirmed that compared to damaged hair not treated with the lipid peptide composition, the damaged hair treated with Example 10 had reduced moisture adsorption.

[Examples 1 and 2: Amount of lipid peptide attached to hair]
30 mL of the Pal-GH aqueous dispersions of Examples 1 and 2, with Pal-GH concentrations of 0.001% by mass, 0.0025% by mass, and 0.005% by mass, respectively, were prepared from Preparation Examples 1 and 2. A bundle of damaged hair (approximately 10 cm, approximately 1 g) that had been bleached three times was immersed in the dispersion and allowed to stand for 30 minutes. The hair was then washed with water, towel-dried, and then dried overnight in a constant-temperature bath at 50°C. The prepared hair-treated sample was sheared to 1 cm, 200 mg was weighed, placed in a 50 mL sample tube, and 10 mL of methanol was added. The sample was then sonicated for 1 hour to extract lipid peptides that had penetrated and adhered to the hair. The extracted lipid peptides were measured by high-performance liquid chromatography (HPLC, Agilent) to calculate the amount of lipid peptides that had penetrated and adhered to the hair. The test was performed three times for each sample, and the average values were calculated. The results are shown in Figure 13. It was confirmed that the amount of lipid peptide attached to the damaged hair treated in both Examples 1 and 2 increased in a concentration-dependent manner.

[Examples 3 to 5: Amount of lipid peptide attached to hair]
30 mL of Pal-GH aqueous dispersions of Examples 3 to 5, each containing Pal-GH at a concentration of 0.0025% by mass, 0.005% by mass, and 0.025% by mass, were prepared, and a bundle of damaged hair (approximately 10 cm, approximately 1 g) that had been bleached three times was immersed and left to stand for 30 minutes. The hair was then washed with water, towel-dried, and then dried overnight in a constant-temperature bath at 50°C. The prepared hair-treated sample was sheared to 1 cm, and 200 mg was weighed and placed in a 50 mL sample tube. 10 mL of methanol was added, and the sample was sonicated for 1 hour to extract lipid peptides that had penetrated and adhered to the hair. The extracted lipid peptides were measured by high-performance liquid chromatography (HPLC, manufactured by Agilent) to calculate the amount of lipid peptides that had penetrated and adhered to the hair. Each sample was tested three times, and the average value was calculated. The results are shown in Figure 14. It was confirmed that the amount of lipid peptide attached to the damaged hair treated in Examples 3 to 5 increased in a concentration-dependent manner.

[Examples 9 and 10: Amount of lipid peptide attached to hair]
30 mL of Pal-GH aqueous dispersions of Examples 9 and 10, with Pal-GH concentrations of 0.0025% by mass, 0.005% by mass, and 0.025% by mass, were prepared from Preparation Examples 9 and 10, respectively. A bundle of damaged hair (approximately 10 cm, approximately 1 g) that had been bleached three times was immersed in the dispersion and allowed to stand for 30 minutes. The hair was then washed with water, towel-dried, and then dried overnight in a constant-temperature bath at 50 °C. The prepared hair-treated sample was sheared to 1 cm, 200 mg was weighed, placed in a 50 mL sample tube, and 10 mL of methanol was added. The sample was then sonicated for 1 hour to extract lipid peptides that had penetrated and adhered to the hair. The extracted lipid peptides were measured by high-performance liquid chromatography (HPLC, manufactured by Agilent) to calculate the amount of lipid peptides that had penetrated and adhered to the hair. The test was performed three times for each sample, and the average value was calculated. The results are shown in Figure 15. The adhesion of lipid peptides to damaged hair treated in Examples 9 and 10 was confirmed at all concentrations.

[Examples 16 and 17: Amount of lipid peptide and succinic acid attached to hair when blended in shampoo and conditioner]
Preparation Examples 1 and 2 were added to a commercially available shampoo (BOTANIST Botanical Shampoo Smooth) and conditioner (BOTANIST Botanical Conditioner Smooth) to prepare the shampoo and conditioner of Examples 16 and 17, respectively, so that the Pal-GH concentration was 0.005% by mass, and succinic acid was blended into these shampoos at 1% by mass. A strand of damaged hair (approximately 10 cm, approximately 1 g) that had been bleached three times was washed with a 10-yen coin-sized amount of each shampoo, rinsed with water, and towel-dried. A 10-yen coin-sized amount of each conditioner was evenly applied to the towel-dried hair, allowed to stand for 30 minutes, rinsed with water, towel-dried, and then dried overnight in a constant-temperature bath at 50°C. The prepared hair treatment sample was sheared to 1 cm, and 200 mg was weighed and placed in a 50 mL sample tube. 10 mL of methanol was added, and the tube was sonicated for 1 hour to extract the lipid peptides and succinic acid that had penetrated and adhered to the hair. The extract was analyzed using a mass spectrometer LC/MS (Waters) to calculate the lipid peptides and succinic acid extracted from the hair. The results are shown in Figures 16 and 17. Figure 16 shows the amount of lipid peptides detected in the hair extract, and Figure 17 shows the amount of succinic acid detected in the hair extract. High penetration of lipid peptides and succinic acid was confirmed in both the damaged hair treated in Example 16 and Example 17.

[Examples 18 to 20: Amount of lipid peptide and succinic acid attached to hair when blended in shampoo and conditioner]
To a commercially available shampoo (Botanist Botanical Shampoo Smooth) and conditioner (Botanist Botanical Conditioner Smooth), Preparation Examples 3 to 5 were added to prepare shampoos and conditioners of Examples 18 to 20 so that the Pal-GH concentration was 0.025% by mass, and succinic acid was blended to the shampoos and conditioners so that the concentration was 1% by mass. A strand of damaged hair (approximately 10 cm, approximately 1 g) that had been bleached three times was washed with a 10-yen coin-sized amount of each shampoo, rinsed with water, and towel-dried. A 10-yen coin-sized amount of each conditioner was evenly applied to the towel-dried hair, allowed to stand for 30 minutes, rinsed with water, towel-dried, and then dried overnight in a constant-temperature bath at 50°C. The prepared hair treatment sample was sheared to 1 cm, and 200 mg was weighed and placed in a 50 mL sample tube. 10 mL of methanol was added, and the tube was sonicated for 1 hour to extract the lipid peptides and succinic acid that had penetrated and adhered to the hair. The extract was analyzed using a mass spectrometer LC/MS (Waters) to calculate the amount of lipid peptides and succinic acid extracted from the hair. The results are shown in Figures 18 and 19. Figure 18 shows the amount of lipid peptides detected in the hair extract, and Figure 19 shows the amount of succinic acid detected in the hair extract. High penetration of lipid peptides and succinic acid was confirmed in all damaged hair treated in Examples 18 to 20.

[Example 5, Comparative Examples 6 and 7: Measurement of Hardness of Lipid Peptide Compositions]
The Pal-GH compositions of Preparation Example 5 and Comparative Preparation Examples 6 and 7 were subjected to breaking strength measurement using a YAMADEN RHEONER II CREEEP METER RE2-33005B (Yamaden Co., Ltd.) at a measurement speed of 1 mm/sec, a measurement strain rate of 80%, a storage pitch of 0.10 sec, and a jig model 30349-3. The results are shown in FIG. 20 . This suggests that the Pal-GH composition of Preparation Example 5 shown in Example 5 has a higher hardness than the Pal-GH compositions of Comparative Preparation Examples 6 and 7 shown in Comparative Examples 6 and 7.

[Example 5 and Comparative Examples 4 to 7: Contact angle measurement of lipid peptide compositions]
The Pal-GH compositions obtained in Preparation Example 5 and Comparative Preparation Examples 4 to 7 above and water were weighed, and the Pal-GH compositions were added to the stirred water in a 200 mL beaker (manufactured by HARIO Corporation). The mixture was stirred for 5 minutes at 200 rpm and allowed to stand at room temperature to dilute the mixture 200 times with water, thereby preparing aqueous dispersions of the Pal-GH compositions (also referred to as Pal-GH aqueous dispersions) as Example 5 and Comparative Examples 4 to 7, respectively.
A Si substrate (manufactured by Matsuzaki Manufacturing Co., Ltd., thickness 525±25 μm) was treated with hexamethyldisiloxane and cut into 2.5 cm × 2.5 cm pieces. 0.25 mL of the prepared 200-fold diluted solution was applied to the substrate and dried in a thermostatic chamber at 32°C for 20 hours. The contact angle was measured when a 2 μL water droplet was placed on the dried film using a fully automatic contact angle meter (manufactured by Kyowa Interface Science Co., Ltd., DM-701). The contact angle was also measured over time at 0.01 minutes, 1.01 minutes, and 3.01 minutes after droplet placement. The results are shown in Figure 22. As can be seen from Figure 22, Example 5 maintained the highest contact angle. The film formed from Example 5 has high water resistance, and is expected to reduce damage associated with water adsorption when applied to hair, for example.

[Example 5, Comparative Examples 4 and 5: Structural analysis of Pal-GH composition by small angle X-ray scattering (SAXS)]
The results of structural analysis by small-angle X-ray scattering (SAXS) for Example 5 (Pal-GH composition obtained in Preparation Example 5), Comparative Example 4 (Pal-GH composition obtained in Comparative Preparation Example 4), and Comparative Example 5 (Pal-GH composition obtained in Comparative Preparation Example 5) are shown in Figure 23. As shown in Figure 23, Example 5 has a different profile from Comparative Examples 4 and 5 in terms of intensity near q = 0.1 ^Å , indicating that the self-assembly patterns formed are different.

[Example 5, Comparative Examples 4 and 5: Structural analysis of aqueous dispersion of Pal-GH composition (200-fold dilution) by SAXS method]
The Pal-GH compositions obtained in Preparation Example 5 and Comparative Preparation Examples 4 and 5 above and water were weighed, and the Pal-GH compositions were added to the stirred water in a 200 mL beaker (manufactured by HARIO Corporation). The mixture was stirred for 5 minutes at 200 rpm and allowed to stand at room temperature to dilute the mixture 200-fold with water, thereby preparing aqueous dispersions of the Pal-GH compositions (also referred to as Pal-GH aqueous dispersions) as Example 5 and Comparative Examples 4 and 5, respectively.
The results of structural analysis by SAXS measurement of the Pal-GH aqueous dispersions of Example 5, Comparative Example 4, and Comparative Example 5 are shown in Figure 24. As shown in Figure 24, Example 5 has a different profile from Comparative Examples 4 and 5 in terms of intensity near q = 0.1 ^Å , indicating that the self-assembly patterns formed are different.

Claims (19)

A composition containing a lipid peptide-type compound in which a peptide portion formed by repeating at least two or more identical or different amino acids is bound to a lipid portion consisting of an aliphatic group having 10 to 24 carbon atoms, a sucrose ester, a 1,2-alkanediol, a fatty acid, and water. The composition of claim 1, wherein the sucrose ester is sucrose polystearate or sucrose stearate. The composition described in claim 2, wherein the 1,2-alkanediol is 1,2-pentanediol or 1,2-hexanediol. The composition according to claim 3, characterized in that the lipid peptide type compound consists of at least one of compounds represented by the following formulas (1) to (3) or pharmaceutically acceptable salts thereof:
(wherein R ¹ represents an aliphatic group having 9 to 23 carbon atoms, R ² represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may have a branched chain and which has 1 or 2 carbon atoms, R ³ represents a -(CH ₂ ) _n -X group, n represents a number from 1 to 4, and X represents an amino group, a guanidino group, a -CONH ₂ group, a 5-membered or 6-membered ring group which may have 1 to 3 nitrogen atoms, or a fused heterocyclic group composed of a 5-membered ring and a 6-membered ring.)
(In the formula, ^R4 represents an aliphatic group having 9 to 23 carbon atoms, ^R5 to ^R7 each independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms which may have a branched chain and which has 1 or 2 carbon atoms, or a -( _CH2 ) _n -X group, where n represents a number from 1 to 4, and X represents an amino group, a guanidino group, a _-CONH2 group, a 5-membered or 6-membered ring group which may have 1 to 3 nitrogen atoms, or a fused heterocyclic group composed of a 5-membered ring and a 6-membered ring.)
(In the formula, ^R8 represents an aliphatic group having 9 to 23 carbon atoms, ^R9 to ^R12 each independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms which may have a branched chain and which has 1 or 2 carbon atoms, or a -( _CH2 ) _n -X group, where n represents a number from 1 to 4, and X represents an amino group, a guanidino group, a _-CONH2 group, a 5-membered or 6-membered ring group which may have 1 to 3 nitrogen atoms, or a fused heterocyclic group composed of a 5-membered ring and a 6-membered ring.) The composition of claim 4, wherein the fatty acid is stearic acid. The composition according to claim 5, wherein the content of the lipid peptide compound is 0.0001% by mass or more and 0.5% by mass or less relative to the total mass of the composition. The composition according to claim 5, wherein the content of the lipid peptide-type compound is 0.001% by mass or more and 0.5% by mass or less, relative to the total mass of the composition; the content of the sucrose ester is 0.0005% by mass or more and 0.25% by mass or less, relative to the total mass of the composition; the content of the 1,2-alkanediol is 0.0014% by mass or more and 0.7% by mass or less, relative to the total mass of the composition; and the content of the fatty acid is 0.0001% by mass or more and 0.05% by mass or less, relative to the total mass of the composition; and the composition is a transparent dispersion at a temperature of 0°C or more and 40°C or less. The composition of claim 7, wherein the lipid peptide compound is palmitoyl-Gly-His. The composition according to claim 5, wherein the content of the lipid peptide compound is 1.0% by mass or more and 20.0% by mass or less, relative to the total mass of the composition. The composition according to claim 5, wherein the content of the lipid peptide type compound is 4.0% by mass or more and 6.0% by mass or less, the content of the sucrose ester is 2.0% by mass or more and 3.0% by mass or less, the content of the 1,2-alkanediol is 5.6% by mass or more and 8.4% by mass or less, the content of the fatty acid is 0.4% by mass or more and 0.6% by mass or less, and the breaking strength is 2.0 to 4.0 x 10 ⁵ Pa. The composition described in claim 10, wherein the lipid peptide compound is palmitoyl-Gly-His. A cosmetic comprising the composition described in claim 5, wherein the content of the lipid peptide compound is 0.0001% by mass or more and 5.0% by mass or less relative to the total mass of the cosmetic. A method for reducing damage to hair, comprising the steps of applying the cosmetic composition according to claim 12 to hair and forming a film. A method for improving the water resistance of hair, comprising the steps of applying the cosmetic composition according to claim 12 to hair and forming a film. The method of claim 13 or 14, wherein the lipid peptide compound is palmitoyl-Gly-His. A method for producing the composition described in claim 5, comprising the steps of mixing the components of the composition described in claim 5 so that the content of the lipid peptide compound is 1.0% by mass or more and 20.0% by mass or less relative to the total mass of the composition, stirring the mixture at room temperature or under heating, and allowing the mixture to cool to obtain a solid composition. A method for producing a dispersion of a lipid peptide compound, comprising the following steps:
A step of mixing the components of the composition according to claim 5 and stirring the mixture at room temperature or under heating to produce a composition having a content of the lipid peptide type compound of 1.0% by mass or more and 20.0% by mass or less relative to the total mass of the composition, and a step of mixing the composition with water and stirring the mixture at room temperature or under heating to produce a liquid composition having a content of the lipid peptide type compound of 0.0001% by mass or more and 0.5% by mass or less. A method for producing a cosmetic, comprising the following steps:
A process for producing a composition in which the content of the lipid peptide type compound obtained by mixing the components of the composition according to claim 5 and stirring the mixture at room temperature or under heating is 1.0% by mass or more and 20.0% by mass or less relative to the total mass of the composition;
storing the resulting composition at room temperature or at low temperature;
a step of mixing the composition with water, stirring at room temperature or with heating, and storing the resulting composition at room temperature or at a low temperature so that the content of the lipid peptide type compound is 0.0001% by mass or more and 0.5% by mass or less; and a step of mixing the composition with water, various solvents, and other additives without heating, and stirring at room temperature or at a low temperature so that the content of the lipid peptide type compound is 0.0001% by mass or more and 0.5% by mass or less, relative to the total mass of the cosmetic, to obtain a cosmetic. A method for producing a cosmetic, comprising the following steps:
A process for producing a composition in which the content of the lipid peptide type compound obtained by mixing the components of the composition according to claim 5 and stirring the mixture at room temperature or under heating is 1.0% by mass or more and 20.0% by mass or less relative to the total mass of the composition;
a step of storing the obtained composition at room temperature or a low temperature, and a step of heating the composition, mixing it with various solvents and other additives, and stirring to obtain a cosmetic product so that the content of the lipid peptide type compound is 0.0001% by mass or more and 5.0% by mass or less relative to the total mass of the cosmetic product.