WO2018190383A1 - Dispersion liquid containing dispersant for pigments or powders - Google Patents

Abstract

[Problem] To provide: a dispersion liquid containing a pigment or powder, which is able to be prevented from separation and sedimentation of the pigment or the like over time; and a dispersant. [Solution] A dispersion liquid which contains: a dispersant for pigments or powders, which is formed of a lipid peptide compound that is composed of at least one compound selected from among compounds represented by formula (1), analogous compounds thereof and pharmaceutically acceptable salts of these compounds; a surfactant; water; 1, 2-alkanediol or 1, 3-alkanediol; a fatty acid; and at least one substance selected from the group consisting of pigments and powders. Also disclosed is the above-described dispersant for pigments or powders. (In the formula, R¹ represents an aliphatic group having 9 to 23 carbon atoms; R² represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, which may have a branched chain having 1 or 2 carbon atoms; R³ represents a –(CH₂)n-X group; n represents a number of 1 to 4; and X represents an amino group, a guanidino group, a –CONH₂ group, or a fused heterocyclic ring that is composed of a five-membered ring and/or a six-membered ring, which may have 1 to 3 nitrogen atoms.)

Description

Dispersion containing pigment or powder dispersant

The present invention relates to a dispersion containing a pigment or a powder dispersant, and in particular, to a dispersion containing a pigment or powder dispersant made of a lipid peptide type compound and the pigment or powder dispersant.

The water-based composition has a high refreshing feeling when applied to the skin, etc., and has a sticky feeling after use compared to the oil-based composition. New products have been put on the market and proposed.
For example, as a solid aqueous composition, conventionally, a solid oil-in-water makeup cosmetic (Patent Document 1) containing water, fatty acid soap, oil and powder, alkyl and / or alkenyl oligoglycoside, oily substance, and nonionic property A stick-shaped aqueous cosmetic (Patent Document 2) containing an emulsifier has been proposed.
As liquid aqueous compositions, there have been many proposals of water-based cosmetics containing water as the main ingredient and various additives such as moisturizers, and emulsion-type compositions containing oily ingredients and aqueous ingredients with emulsifiers. Has been.

JP-A-3-279319 JP-T-2002-516818

In the above-mentioned aqueous cosmetics, for example, many products containing various pigments and powders for coloring the skin have been proposed, but when these aqueous cosmetics are left standing for a long period of time, the pigments and powders are separated.・ Sedimentation and in some cases hard cake.
Therefore, proposals to stabilize dispersions by blending various resins, thickeners, dispersants, and other additives have been studied, and the separation and sedimentation of pigments and powders, as well as the aggregation and solidification of them, are being investigated. Technical proposals that can be controlled are required.

The present invention has been made on the basis of the above circumstances, and the problem to be solved is a dispersion and a dispersing agent capable of preventing separation and settling of pigments and the like over time in a dispersion containing pigment or powder. Is to provide.

As a result of diligent research to solve the above problems, the present inventors have found that a dispersion using a lipid peptide type compound comprising a low-molecular-weight lipid peptide or a pharmaceutically usable salt thereof as a dispersant for pigments or powders The inventors have found that a dispersion in which separation and sedimentation with time in the blended pigments and the like are suppressed can be obtained, and the present invention has been completed.

（式中、Ｒ^１は炭素原子数９乃至２３の脂肪族基を表し、Ｒ^２は水素原子、又は炭素原子数１若しくは２の分枝鎖を有し得る炭素原子数１乃至４のアルキル基を表し、Ｒ^３は－（ＣＨ_２）ｎ－Ｘ基を表し、ｎは１乃至４の数を表し、Ｘはアミノ基、グアニジノ基、－ＣＯＮＨ_２基、又は窒素原子を１乃至３個有し得る５員環若しくは６員環又は５員環と６員環から構成される縮合複素環を表す。）

（式中、Ｒ^４は炭素原子数９乃至２３の脂肪族基を表し、Ｒ^５乃至Ｒ^７はそれぞれ独立して水素原子、炭素原子数１若しくは２の分枝鎖を有し得る炭素原子数１乃至４のアルキル基、又は－（ＣＨ_２）ｎ－Ｘ基を表し、且つＲ^５乃至Ｒ^７のうち少なくとも一つ以上が－（ＣＨ_２）ｎ－Ｘ基を表し、ｎは１乃至４の数を表し、Ｘはアミノ基、グアニジノ基、－ＣＯＮＨ_２基、又は窒素原子を１乃至３個有し得る５員環若しくは６員環又は５員環と６員環から構成される縮合複素環を表す。）

（式中、Ｒ^８は炭素原子数９乃至２３の脂肪族基を表し、Ｒ^９乃至Ｒ^１２はそれぞれ独立して水素原子、炭素原子数１若しくは２の分枝鎖を有し得る炭素原子数１乃至４のアルキル基、又は－（ＣＨ_２）ｎ－Ｘ基を表し、且つＲ^９乃至Ｒ^１２のうち少なくとも一つ以上が－（ＣＨ_２）ｎ－Ｘ基を表し、ｎは１乃至４の数を表し、Ｘはアミノ基、グアニジノ基、－ＣＯＮＨ_２基、又は窒素原子を１乃至３個有し得る５員環若しくは６員環又は５員環と６員環から構成される縮合複素環を表す。）
　第２観点として、前記顔料及び粉体からなる群から選択される少なくとも一種が、分散液の総質量に基いて２５質量％以下の割合にて含まれてなる、第１観点に記載の分散液に関する。
　第３観点として、前記顔料又は粉体用分散剤が、分散液の総質量に基いて０．０１質量％乃至１質量％の割合にて含まれてなる、第１観点又は第２観点に記載の分散液。
　第４観点として、さらに多価アルコールを含む、第１観点乃至第３観点のうち何れか一項に記載の分散液に関する。
　第５観点として、前記多価アルコールが、グリセリンである、第４観点に記載の分散液に関する。
　第６観点として、前記界面活性剤が、エチレングリコールアルキルエーテル、リン脂質、ポリグリセリン脂肪酸エステル及びポリオキシエチレンポリオキシプロピレンアルキルエーテルからなる群から選択される１種類以上の化合物である、第１観点乃至第５観点のうち何れか一項に記載の分散液に関する。
　第７観点として、前記脂肪酸がステアリン酸である、第１観点乃至第６観点のうち何れか一項に記載の分散液に関する。
　第８観点として、化粧料用の分散液である、第１観点乃至第７観点のうち何れか一項に記載の分散液に関する。
　第９観点として、下記式（１）乃至式（３）で表される化合物又はその薬学的に使用可能な塩のうちの少なくとも一種からなる脂質ペプチド型化合物からなる顔料又は粉体用分散剤に関する。

（式中、Ｒ^１は炭素原子数９乃至２３の脂肪族基を表し、Ｒ^２は水素原子、又は炭素原子数１若しくは２の分枝鎖を有し得る炭素原子数１乃至４のアルキル基を表し、Ｒ^３は－（ＣＨ_２）ｎ－Ｘ基を表し、ｎは１乃至４の数を表し、Ｘはアミノ基、グアニジノ基、－ＣＯＮＨ_２基、又は窒素原子を１乃至３個有し得る５員環若しくは６員環又は５員環と６員環から構成される縮合複素環を表す。）

（式中、Ｒ^４は炭素原子数９乃至２３の脂肪族基を表し、Ｒ^５乃至Ｒ^７はそれぞれ独立して水素原子、炭素原子数１若しくは２の分枝鎖を有し得る炭素原子数１乃至４のアルキル基、又は－（ＣＨ_２）ｎ－Ｘ基を表し、且つＲ^５乃至Ｒ^７のうち少なくとも一つ以上が－（ＣＨ_２）ｎ－Ｘ基を表し、ｎは１乃至４の数を表し、Ｘはアミノ基、グアニジノ基、－ＣＯＮＨ_２基、又は窒素原子を１乃至３個有し得る５員環若しくは６員環又は５員環と６員環から構成される縮合複素環を表す。）

（式中、Ｒ^８は炭素原子数９乃至２３の脂肪族基を表し、Ｒ^９乃至Ｒ^１２はそれぞれ独立して水素原子、炭素原子数１若しくは２の分枝鎖を有し得る炭素原子数１乃至４のアルキル基、又は－（ＣＨ_２）ｎ－Ｘ基を表し、且つＲ^９乃至Ｒ^１２のうち少なくとも一つ以上が－（ＣＨ_２）ｎ－Ｘ基を表し、ｎは１乃至４の数を表し、Ｘはアミノ基、グアニジノ基、－ＣＯＮＨ_２基、又は窒素原子を１乃至３個有し得る５員環若しくは６員環又は５員環と６員環から構成される縮合複素環を表す。） That is, the present invention provides the first aspect as follows:
A surfactant,
water and,
A pigment or powder dispersant comprising a lipid peptide type compound comprising at least one of the compounds represented by the following formulas (1) to (3) or a pharmaceutically usable salt thereof:
1,2-alkanediol or 1,3-alkanediol;
At least one fatty acid,
Including at least one selected from the group consisting of pigments and powders,
Concerning the dispersion.

(Wherein R ¹ represents an aliphatic group having 9 to 23 carbon atoms, R ² represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms) R ³ represents a — (CH ₂ ) n—X group, n represents a number of 1 to 4, X represents an amino group, a guanidino group, a —CONH ₂ group, or 1 to 3 nitrogen atoms. And represents a condensed heterocyclic ring composed of a 5-membered ring or a 6-membered ring or a 5-membered ring and a 6-membered ring.)

(Wherein R ⁴ represents an aliphatic group having 9 to 23 carbon atoms, and R ^{5 to} R ⁷ each independently represents a hydrogen atom, or a carbon atom number that can have a branched chain having 1 or 2 carbon atoms. 1 to 4 alkyl groups or — (CH ₂ ) n—X groups, and at least one of R ^{5 to} R ⁷ represents — (CH ₂ ) n—X groups, and n is 1 to 4 X represents an amino group, a guanidino group, a —CONH ₂ group, or a 5- or 6-membered ring having 1 to 3 nitrogen atoms, or a condensed heterocycle composed of a 5-membered ring and a 6-membered ring. Represents a ring.)

(In the formula, R ⁸ represents an aliphatic group having 9 to 23 carbon atoms, and R ^{9 to} R ¹² each independently represents a hydrogen atom, or the number of carbon atoms that may have a branched chain having 1 or 2 carbon atoms. 1 to 4 alkyl groups or — (CH ₂ ) n—X groups, and at least one of R ^{9 to} R ¹² represents — (CH ₂ ) n—X groups, and n is 1 to 4 X represents an amino group, a guanidino group, a —CONH ₂ group, or a 5- or 6-membered ring having 1 to 3 nitrogen atoms, or a condensed heterocycle composed of a 5-membered ring and a 6-membered ring. Represents a ring.)
As a second aspect, the dispersion according to the first aspect, wherein at least one selected from the group consisting of the pigment and the powder is contained in a proportion of 25% by mass or less based on the total mass of the dispersion. About.
As a third aspect, the pigment or the dispersant for powder is included in a ratio of 0.01% by mass to 1% by mass based on the total mass of the dispersion, described in the first aspect or the second aspect. Dispersion.
As a 4th viewpoint, it is related with the dispersion liquid as described in any one of the 1st viewpoint thru | or a 3rd viewpoint containing a polyhydric alcohol further.
As a 5th viewpoint, the said polyhydric alcohol is related with the dispersion liquid as described in a 4th viewpoint which is glycerol.
As a sixth aspect, the surfactant is one or more compounds selected from the group consisting of ethylene glycol alkyl ethers, phospholipids, polyglycerin fatty acid esters, and polyoxyethylene polyoxypropylene alkyl ethers. Thru | or 5th viewpoint It is related with the dispersion liquid as described in any one.
As a seventh aspect, the present invention relates to the dispersion according to any one of the first to sixth aspects, in which the fatty acid is stearic acid.
As an 8th viewpoint, it is related with the dispersion liquid as described in any one among the 1st viewpoint thru | or the 7th viewpoint which is a dispersion liquid for cosmetics.
As a ninth aspect, the present invention relates to a pigment or a powder dispersant composed of a lipid peptide compound composed of at least one of the compounds represented by the following formulas (1) to (3) or a pharmaceutically usable salt thereof. .

(Wherein R ¹ represents an aliphatic group having 9 to 23 carbon atoms, R ² represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms) R ³ represents a — (CH ₂ ) n—X group, n represents a number of 1 to 4, X represents an amino group, a guanidino group, a —CONH ₂ group, or 1 to 3 nitrogen atoms. And represents a condensed heterocyclic ring composed of a 5-membered ring or a 6-membered ring or a 5-membered ring and a 6-membered ring.)

(Wherein R ⁴ represents an aliphatic group having 9 to 23 carbon atoms, and R ^{5 to} R ⁷ each independently represents a hydrogen atom, or a carbon atom number that can have a branched chain having 1 or 2 carbon atoms. 1 to 4 alkyl groups or — (CH ₂ ) n—X groups, and at least one of R ^{5 to} R ⁷ represents — (CH ₂ ) n—X groups, and n is 1 to 4 X represents an amino group, a guanidino group, a —CONH ₂ group, or a 5- or 6-membered ring having 1 to 3 nitrogen atoms, or a condensed heterocycle composed of a 5-membered ring and a 6-membered ring. Represents a ring.)

(In the formula, R ⁸ represents an aliphatic group having 9 to 23 carbon atoms, and R ^{9 to} R ¹² each independently represents a hydrogen atom, or the number of carbon atoms that may have a branched chain having 1 or 2 carbon atoms. 1 to 4 alkyl groups or — (CH ₂ ) n—X groups, and at least one of R ^{9 to} R ¹² represents — (CH ₂ ) n—X groups, and n is 1 to 4 X represents an amino group, a guanidino group, a —CONH ₂ group, or a 5- or 6-membered ring having 1 to 3 nitrogen atoms, or a condensed heterocycle composed of a 5-membered ring and a 6-membered ring. Represents a ring.)

According to the present invention, by using a lipid peptide type compound as a dispersant for pigments or powders, the pigments and powders can be stably dispersed without being separated or settled from the dispersion over time. It can be set as the made dispersion liquid.
In particular, by using the dispersant of the present invention, a stably dispersed dispersion can be prepared even when 10% by mass or more of the pigment is blended or when a relatively large powder such as a gold foil is blended.

The lipid peptide compound constituting the dispersant of the present invention is a very safe artificial low molecular weight compound composed only of lipid and peptide.
Furthermore, various components contained as additives in the dispersion of the present invention are general-purpose additives as additives for foods, cosmetics, and pharmaceuticals.
That is, the dispersion of the present invention has high biological safety, and is particularly useful in the above applications from the viewpoint of safety required for pharmaceuticals and cosmetics.
In addition, the dispersion of the present invention is expected to be a dispersion with good refreshing feeling and elongation when applied to human skin or the like, and is a liquid base containing pigments and powders for pharmaceuticals and cosmetics. It can be expected to be used as a material and is very useful.

FIG. 1 shows the formulation of 10% by mass of pigments prepared in Examples 1 to 3 and Comparative Example 1 (Example 1, Example 2 and Comparative Example 1) and 15% by mass of pigment (Example 3). It is a figure which shows an external appearance. FIG. 2 is a view showing the appearance of a dispersion liquid containing a pearl pigment prepared in Example 4, Example 5, and Comparative Example 2. FIG. 3 is a view showing the appearance of a dispersion liquid containing tricalcium phosphate prepared in Example 6 and Comparative Example 3. FIG. 4 is a view showing the appearance of a dispersion of gold foil blends prepared in Example 7, Example 8, and Comparative Example 4. FIG. 5 is a view showing an observation result (photograph) of a polarizing microscope of the O / W liquid foundation prepared in Example 9 and Comparative Example 5. FIG. 6 is a view showing the appearance of the O / W liquid foundation prepared in Example 9 and Comparative Example 5 after one month of preparation.

The present invention relates to a pigment comprising a lipid peptide compound comprising a surfactant, water, and a compound represented by the following formulas (1) to (3) or a pharmaceutically usable salt thereof: Or a dispersion containing a dispersant for powder, 1,2-alkanediol or 1,3-alkanediol, fatty acid, at least one selected from the group consisting of pigments and powder, and optionally other additives. Regarding liquids. The present invention is also directed to a pigment or powder dispersant comprising the lipid peptide type compound.
Hereinafter, each component will be described.

[Dispersant for pigment or powder: lipid peptide type compound]
The lipid peptide type compound used as the pigment or powder dispersant of the present invention is a compound (lipid peptide) represented by the following formulas (1) to (3) or a pharmaceutically usable salt thereof (hydrophobic) A low molecular compound having a lipid part as a site and a peptide part as a hydrophilic site can be used.

In the above formula (1), R ¹ represents an aliphatic group having 9 to 23 carbon atoms, and preferably R ¹ is a straight chain having 11 to 23 carbon atoms which may have 0 to 2 unsaturated bonds. An aliphatic group is desirable.
Specific examples of the lipid moiety (acyl group) composed of a carbonyl group adjacent to R ¹ include lauroyl group, dodecylcarbonyl group, myristoyl group, tetradecylcarbonyl group, palmitoyl group, margaroyl group, oleoyl group, and elideoyl group. Linoleoyl group, stearoyl group, baccenoyl group, octadecylcarbonyl group, arachidyl group, eicosylcarbonyl group, behenoyl group, ercanoyl group, docosylcarbonyl group, lignoceyl group, nerbonoyl group, etc. Examples include lauroyl group, myristoyl group, palmitoyl group, margaroyl group, stearoyl group, oleoyl group, elidoyl group, and behenoyl group.

In the above formula (1), R ² contained in the peptide part represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms.
The alkyl group having 1 to 4 carbon atoms that may have a branched chain having 1 or 2 carbon atoms is a branched chain having 1 to 4 carbon atoms in the main chain and 1 or 2 carbon atoms. Means an alkyl group which may have, and specific examples thereof include methyl group, ethyl group, n-propyl group, i-propyl group, n-butyl group, i-butyl group, sec-butyl group or tert-butyl group Etc.
R ² is preferably a hydrogen atom or an alkyl group having 1 to 3 carbon atoms which may have a branched chain having 1 carbon atom, and more preferably a hydrogen atom.
The alkyl group having 1 to 3 carbon atoms which can have a branched chain having 1 carbon atom is an alkyl group having 1 to 3 carbon atoms in the main chain and having a branched chain having 1 carbon atom. Specific examples thereof include a methyl group, an ethyl group, an n-propyl group, an i-propyl group, an i-butyl group, or a sec-butyl group, preferably a methyl group, an i-propyl group, An i-butyl group or a sec-butyl group.

In the above formula (1), R ³ represents a — (CH ₂ ) n—X group. In the — (CH ₂ ) n—X group, n represents a number of 1 to 4, and X is an amino group, a guanidino group, a —CONH ₂ group, or a 5-membered cyclic group having 1 to 3 nitrogen atoms. Represents a group, a 6-membered cyclic group, or a condensed heterocyclic group composed of a 5-membered ring and a 6-membered ring.
In the — (CH ₂ ) n—X group representing R ³ , X is preferably an amino group, guanidino group, carbamoyl group (—CONH ₂ group), pyrrole group, imidazole group, pyrazole group or indole group, and more Preferably it is an imidazole group. In the — (CH ₂ ) n—X group, n is preferably 1 or 2, and more preferably 1.
Therefore, the — (CH ₂ ) n- group is preferably an aminomethyl group, 2-aminoethyl group, 3-aminopropyl group, 4-aminobutyl group, carbamoylmethyl group, 2-carbamoylethyl group, 3-carbamoyl group. Represents a butyl group, a 2-guanidinoethyl group, a 3-guanidinobutyl group, a pyrrolemethyl group, a 4-imidazolemethyl group, a pyrazolemethyl group, or a 3-indolemethyl group, more preferably a 4-aminobutyl group, a carbamoylmethyl group Represents a 2-carbamoylethyl group, a 3-guanidinobutyl group, a 4-imidazolemethyl group or a 3-indolemethyl group, more preferably a 4-imidazolemethyl group.

In the compound represented by the above formula (1), a lipid peptide particularly suitable as a lipid peptide type compound is a compound formed from the following lipid part and peptide part (amino acid assembly part). As abbreviations for amino acids, alanine (Ala), asparagine (Asn), glutamine (Gln), glycine (Gly), histidine (His), isorosine (Ile), leucine (Leu), lysine (Lys), tryptophan (Trp) ), Valine (Val). Lauroyl-Gly-His, Lauroyl-Gly-Gln, Lauroyl-Gly-Asn, Lauroyl-Gly-Trp, Lauroyl-Gly-Lys, Lauroyl-Ala-His, Lauroyl-Ala-Gln, Lauroyl-Ala-Asn, Lauroyl -Ala-Trp, Lauroyl-Ala-Lys; Myristoyl-Gly-His, Myristoyl-Gly-Gln, Myristoyl-Gly-Asn, Myristoyl-Gly-Trp, Myristoyl-Gly-Lys, Myristoyl-Ala-His, Myristoyl-Ala -Gln, Myristoyl-Ala-Asn, Myristoyl-Ala-Trp, Myristoyl-Ala-Lys; Palmitoyl-Gly-His, Palmitoyl-Gly-Gln, Palmitoyl-Gly-A n, Palmitoyl-Gly-Trp, Palmitoyl-Gly-Lys, Palmitoyl-Ala-His, Palmitoyl-Ala-Gln, Palmitoyl-Ala-Asn, Palmitoyl-Ala-Trp, Palmitoyl-Ala-Lys; Stearoyl-Gly-His Stearoyl-Gly-Gln, stearoyl-Gly-Asn, stearoyl-Gly-Trp, stearoyl-Gly-Lys, stearoyl-Ala-His, stearoyl-Ala-Gln, stearoyl-Ala-Asn, stearoyl-Ala-Trp, stearoyl- Ala-Lys.

Most preferred are lauroyl-Gly-His, lauroyl-Ala-His-myristoyl-Gly-His, myristoyl-Ala-His; palmitoyl-Gly-His, palmitoyl-Ala-His; stearoyl-Gly-His, stearoyl-Ala -His.

In the above formula (2), R ⁴ represents an aliphatic group having 9 to 23 carbon atoms, and preferred specific examples include the same groups as defined for R ¹ above.
In the above formula (2), R ^{5 to} R ⁷ each independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms, or — ( CH ₂ ) nX group, and at least one of R ^{5 to} R ⁷ represents a — (CH ₂ ) nX group. n represents a number of 1 to 4, and X represents an amino group, a guanidino group, a —CONH ₂ group, or a 5-membered cyclic group or a 6-membered cyclic group which may have 1 to 3 nitrogen atoms, or a 5-membered ring And a condensed heterocyclic group composed of a 6-membered ring. Here, preferred specific examples of R ^{5 to} R ⁷ include the same groups as defined for R ² and R ³ above.

In the compound represented by the above formula (2), a preferable lipid peptide is a compound formed from the following lipid part and peptide part (amino acid assembly part). For example, lauroyl-Gly-Gly-His, lauroyl-Gly-Gly-Gln, lauroyl-Gly-Gly-Asn, lauroyl-Gly-Gly-Trp, lauroyl-Gly-Gly-Lys, lauroyl-Gly-Ala-His, Lauroyl-Gly-Ala-Gln, Lauroyl-Gly-Ala-Asn, Lauroyl-Gly-Ala-Trp, Lauroyl-Gly-Ala-Lys, Lauroyl-Ala-Gly-His, Lauroyl-Ala-Gly-Gln, Lauroyl- Ala-Gly-Asn, Lauroyl-Ala-Gly-Trp, Lauroyl-Ala-Gly-Lys, Lauroyl-Gly-His-Gly, Lauroyl-His-Gly-Gly, Myristoyl-Gly-Gly-His, Myristo Lu-Gly-Gly-Gln, Myristoyl-Gly-Gly-Asn, Myristoyl-Gly-Gly-Trp, Myristoyl-Gly-Gly-Lys, Myristoyl-Gly-Ala-His, Myristoyl-Gly-Ala-Gln, Myristoyl- Gly-Ala-Asn, Myristoyl-Gly-Ala-Trp, Myristoyl-Gly-Ala-Lys, Myristoyl-Ala-Gly-His, Myristoyl-Ala-Gly-Gln, Myristoyl-Ala-Gly-Asn, Myristoyl-Ala- Gly-Trp, Myristoyl-Ala-Gly-Lys, Myristoyl-Gly-His-Gly, Myristoyl-His-Gly-Gly, Palmitoyl-Gly-Gly-His, Palmitoyl-Gly-Gly Gln, Palmitoyl-Gly-Gly-Asn, Palmitoyl-Gly-Gly-Trp, Palmitoyl-Gly-Gly-Lys, Palmitoyl-Gly-Ala-His, Palmitoyl-Gly-Ala-Gln, Palmitoyl-Gly-Aly-Gly-Aly-Gly-Aly Palmitoyl-Gly-Ala-Trp, Palmitoyl-Gly-Ala-Lys, Palmitoyl-Ala-Gly-His, Palmitoyl-Ala-Gly-Gln, Palmitoyl-Ala-Gly-Asn, Palmitoyl-Ala-Gly-Trp Ala-Gly-Lys, Palmitoyl-Gly-His-Gly, Palmitoyl-His-Gly-Gly, Stearoyl-Gly-Gly-His, Stearoyl-Gly-Gly-Gln, Stearoyl -Gly-Gly-Asn, stearoyl-Gly-Gly-Trp, stearoyl-Gly-Gly-Lys, stearoyl-Gly-Ala-His, stearoyl-Gly-Ala-Gln, stearoyl-Gly-Ala-Asn, stearoyl-Gly -Ala-Trp, stearoyl-Gly-Ala-Lys, stearoyl-Ala-Gly-His, stearoyl-Ala-Gly-Gln, stearoyl-Ala-Gly-Asn, stearoyl-Ala-Gly-Trp, stearoyl-Ala-Gly -Lys, stearoyl-Gly-His-Gly, stearoyl-His-Gly-Gly.

Of these, lauroyl-Gly-Gly-His, myristoyl-Gly-Gly-His, palmitoyl-Gly-Gly-His, palmitoyl-Gly-His-Gly, palmitoyl-His-Gly-Gly, stearoyl -Gly-Gly-His.

In the above formula (3), R ⁸ represents an aliphatic group having 9 to 23 carbon atoms, and preferred specific examples include the same groups as defined for R ¹ above.
In the above formula (3), R ^{9 to} R ¹² are each independently a hydrogen atom, an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms, or — ( CH ₂ ) nX group, and at least one of R ^{9 to} R ¹² represents a — (CH ₂ ) nX group. n represents a number of 1 to 4, and X represents an amino group, a guanidino group, a —CONH ₂ group, or a 5-membered cyclic group or a 6-membered cyclic group which may have 1 to 3 nitrogen atoms, or a 5-membered ring And a condensed heterocyclic group composed of a 6-membered ring. Here, preferred specific examples of R ^{9 to} R ¹² include the same groups as defined for R ² and R ³ above.

Therefore, in the compound represented by the above formula (3), as preferred lipid peptide type compounds, particularly preferred lipid peptides include lauroyl-Gly-Gly-Gly-His, myristoyl-Gly-Gly-Gly-His, palmitoyl. -Gly-Gly-Gly-His, Palmitoyl-Gly-Gly-His-Gly, Palmitoyl-Gly-His-Gly-Gly, Palmitoyl-His-Gly-Gly-Gly, Stearoyl-Gly-Gly-Gly-His, etc. Can be mentioned.

In the present invention, the amount of the lipid peptide type compound that is a pigment or a dispersant for powder is, for example, 0.01% by mass to 1% by mass, or 0.01% by mass with respect to the total mass of the resulting dispersion. These are less than 1% by mass, preferably 0.05% by mass to 0.5% by mass, more preferably 0.05% by mass to 0.3% by mass, for example 0.05% by mass to 0.2% by mass.
The lipid peptide type compound used in the present invention comprises at least one of the compounds represented by the above formulas (1) to (3) (lipid peptide) or a pharmaceutically usable salt thereof, These compounds can be used alone or in combination of two or more as a dispersant for powder.

[Surfactant]
As the surfactant used in the dispersion of the present invention, a compound having a hydrophilic part and a hydrophobic part in the molecule, and the hydrophilic part having a betaine structure (hereinafter also referred to as a betaine compound), ethylene glycol alkyl ether, Polyglycerin fatty acid ester or polyoxyethylene polyoxypropylene alkyl ether can be preferably used.

Examples of the betaine compounds as described above include N-alkyl-N, N-dimethylamino acid betaines such as lauryldimethylaminoacetic acid betaine (lauryl betaine); fatty acid amide alkyl-N such as cocamidopropyl betaine and lauramidopropyl betaine. N-dimethylamino acid betaine; imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkylsulfobetaines such as laurylhydroxysulfobetaine and alkyldimethyltaurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate; alkyldimethylaminoethanol Known betaine compounds such as phosphate-type betaines such as phosphate esters can be used as amphoteric surfactants.
Examples of the betaine compounds include phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, phosphatidylglycerol, diphosphatidylglycerol (cardiolipin), phosphatidic acid and other glycerophospholipids; lysophosphatidylcholine (lysolecithin), lysophosphatidylethanolamine, Examples thereof include lysoglycerophospholipids such as serine, lysophosphatidylinositol, lysophosphatidylglycerol, and lysophosphatidic acid; sphingophospholipids such as sphingomyelin; and hydrogenated products thereof. These phospholipids may be derived from animals and plants such as soybeans and egg yolks, or may be synthesized by a chemical or enzymatic method.
Among the betaine compounds, preferably lauryldimethylaminoacetic acid betaine, lauric acid amidopropyl betaine, lauryl hydroxysulfobetaine, stearyl betaine, lysophosphatidylcholine (lysolecithin), lysophosphatidylethanolamine, lysophosphatidylserine, lysophosphatidylinositol, lyso Examples thereof include phosphatidylglycerol and lysophosphatidic acid, and more preferably lysophosphatidylcholine (lysolecithin).

Examples of the ethylene glycol alkyl ether include polyoxyethylene alkyl ether, polyoxyethylene lauryl ether, polyoxyethylene palmitoyl ether, polyoxyethylene stearyl ether and the like. Also, commercially available ethylene glycol alkyl ethers can be used. Examples of such products include Emulgen 102KG, Emargen 103, and Emulgen 104P in Kao's Emulgen (registered trademark) series and Emanon (registered trademark) series. Emulgen 105, Emulgen 106, Emulgen 108, Emulgen 109P, Emulgen 120P, Emulgen 123P, Emulgen 130K, Emulgen 147, Emulgen 150, Emulgen 210P, Emulgen 220, Emulgen 306P, Emulgen 320P, Emulgen 350, Emulgen 404, Emulgen 408, Emulgen 409PV, Emulgen 420, Emulgen 430, Emulgen 705, Emulgen 707, Emulgen 709, Emulgen 1108, Emulgen 1118S-70, Emulgen 1135S-70, Emulgen 1150S-60, Emulgen 4085, Emulgen 2020G-HA, Emulgen 2025G, Emanon 1112, Emanor 3199V, Emanon 3299V, Emanon 3299RV, include the Emanon 4110. More preferably, Kao's Emulgen 103, Emulgen 104P, Emulgen 105, Emulgen 106, Emulgen 108, Emulgen 109P, Emulgen 210P, Emulgen 306P, Emulgen 320P, Emulgen 404, Emulgen 408, Emulgen 409PV, Emulgen 420, Emulgen 705 , Emulgen 707, Emulgen 709, Emulgen 1108, Emulgen 2020G-HA, Emanon 1112, Emanon 4110. More preferably, Kao's Emulgen 104P, Emulgen 105, Emulgen 106, Emulgen 108, Emulgen 210P, Emulgen 306P, Emulgen 408, Emulgen 409PV, Emulgen 705, Emulgen 707, Emulgen 709, Emulgen 1108, Emulgen 2020G-HA, Emanon 1112, Emanon 4110. In addition to this, it can be appropriately selected from the NIKKOL (registered trademark) series of Nikko Chemicals. For example, NIKKOL BT-5, NIKKOL BT-7, NIKKOL BT-9, NIKKOL BT-12, NIKKOL BL-2, NIKKOL BL-4.2, NIKKOL BL-9EX, etc., most preferably NIKOL BL-9EX 4.2.

Examples of the polyglycerin fatty acid ester include glyceryl stearate, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, glyceryl coconut oil fatty acid, mono-cotton oil fatty acid glycerin, glyceryl monosulcate, glyceryl sesquioleate, α, α '-Glycerin fatty acid partial esters such as glyceryl oleate, glyceryl monostearate, and malic monostearate; polyglyceryl stearate-2, 3, 4, 5, 6, 6, 8, 10 polyglyceryl distearate 6, same 10, polyglyceryl tristearate-2, polyglyceryl 10 decastearate, polyglyceryl-2 isostearate 3, 3, 4, 5, 6, 8, 8, 10 Liglyceryl-2 (diglyceryl diisostearate), 3, 10 (decaglyceryl diisostearate), polyglyceryl triisostearate, polyglyceryl-2 tetraisostearate, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, 3, 4, 5, 6, 8, 10, dioleate polyglyceryl-6, trioleate polyglyceryl-2, dekaoleate polyglyceryl-10, and the like.

Polyoxyethylene polyoxypropylene alkyl ethers include Kao's Emulgen (registered trademark) LS-106, Emulgen LS-110, Emulgen LS-114, Emulgen MS-110, and Nikko Chemicals' NIKKOL (registered) Trademarks) PBC-31, NIKKOL PBC-33, NIKKOL PBC-34, NIKKOL PBC-41, NIKKOL PBC-44, NIKKOL PBN-4612, NIKKOL PBN-4620, NIKKOL PBN-4630. More preferred are Emulgen LS-106, Emulgen LS-110, Emulgen LS-114, and Emulgen MS-110. More preferred are Emulgen LS-106, Emulgen LS-110, and Emulgen MS-110.

In addition, as the surfactant used in the present invention, those having an HLB (Hydrophile-Lipophile Balance) value of 8 to 20 can be preferably used. More preferably, the HLB value is 8 to 14.
Examples of such surfactants include sorbitan isostearate, steareth-8, behenez-10, laureth-4, laureth-5, ceteth-7, oleth-8, PEG-8 glyceryl isostearate, choles-10, isostearic acid Acid PEG-10BG, PEG-30 glyceryl triisostearate, PEG-30 glyceryl triisostearate, PEG-30 glyceryl trioleate, PEG-30 triisostearate PEG-30, hydrogenated castor oil lauric acid PEG-30, PCA PEG-30 isostearic acid hydrogenated castor oil, octyldedes-10, PEG-12 dilaurate, sorbes-40 tetraoleate, polyglyceryl-10 diisostearate (decaglyceryl diisostearate), diisos PEG-20 glyceryl acrylate, PEG-8 isostearate, PEG-10 glyceryl isostearate, PEG-60 triisostearate hydrogenated castor oil, PPG-2-Decess-7, Ores-10, hydrogenated dimerino 20, palm fatty acid sorbitan, isosteares-10, steareth-11, trimyristate PEG-30 trimethylolpropane, isostearic acid PEG-40 hydrogenated castor oil, isostearic acid PEG-40 hydrogenated castor oil, PCA isostearic acid PEG-40 Hydrogenated castor oil, laureth-7, isocetes-10, ceteth-10, PEG-10 isostearate, PEG-10 stearate, PEG-10 oleate, PEG-10 glyceryl stearate, oles-12, decyltetradeces -15, co -15, PEG-16 dilaurate, PEG-30 hydrogenated castor oil, PEG-40 glyceryl triisostearate, PEG-40 glyceryl trioleate, PEG-40 trimethylolpropane triisostearate, PEG-40 water laurate Examples thereof include castor oil and PEG-12 laurate.

In the present invention, the compounding amount of the surfactant is, for example, 0.01% by mass to 2% by mass, or, for example, 0.01% by mass to 1% by mass, preferably 0% with respect to the total mass of the resulting dispersion. 0.01 mass% to 0.5 mass%, more preferably 0.01 mass% to 0.3 mass%, for example 0.02 mass% to 0.2 mass%.
The surfactant used in the present invention is at least one of the above-mentioned surfactant group, and these surfactants can be used alone or in combination of two or more.

[1,2-alkanediol or 1,3-alkanediol]
The 1,2-alkanediol or 1,3-alkanediol used in the dispersion of the present invention has a function of promoting the solubility of the lipid peptide type compound which is the pigment or powder dispersant.
Specific examples of the 1,2-alkanediol include 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol, and the like. Preferred are 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol. More preferred is 1,2-pentanediol or 1,2-hexanediol.
Specific examples of the 1,3-alkanediol include 1,3-propanediol, 2-methyl-1,3-propanediol, 1,3-butanediol, 3-methyl-1,3-butanediol, , 3-pentanediol, 1,3-hexanediol, 2-ethyl-1,3-hexanediol, 2-ethyl-1,3-octanediol, 1,3-decanediol, and the like. Preferred are 1,3-butanediol, 1,3-pentanediol, 1,3-hexanediol, 2-ethyl-1,3-hexanediol, and 2-ethyl-1,3-octanediol. More preferred are 1,3-butanediol, 2-ethyl-1,3-hexanediol, and 2-ethyl-1,3-octanediol.
These 1,2-alkanediols or 1,3-alkanediols can be used alone or in combination of two or more.

In the present invention, the blending amount of 1,2-alkanediol or 1,3-alkanediol is, for example, 0.001% by mass to 15% by mass, preferably 0.001% by mass with respect to the total mass of the resulting dispersion. 005 mass% to 15 mass%, more preferably 0.01 mass% to 15 mass%, for example 0.01 mass% to 12 mass%.

[fatty acid]
The fatty acid used in the dispersion of the present invention is preferably at least one selected from the group consisting of saturated and unsaturated fatty acids having 10 to 20 carbon atoms and salts of these fatty acids. For example, the fatty acid is capric acid. , Undecanoic acid, lauric acid, tridecanoic acid, myristic acid, pentadecanoic acid, palmitic acid, margaric acid, stearic acid. More preferably, capric acid, lauric acid, myristic acid, palmitic acid, and stearic acid are mentioned, and stearic acid is particularly preferable.
In the present invention, the amount of fatty acid used is, for example, 0.001% to 1% by weight, preferably 0.001% to 0.1% by weight, based on the total weight of the resulting dispersion. Preferably it is 0.005 mass% thru | or 0.05 mass%.
In addition, the fatty acid used in this invention is at least 1 sort (s) selected from the said fatty acid group, These fatty acids can be used individually or in combination of 2 or more types.

[Pigment or powder]
The pigment or powder blended in the dispersion of the present invention is not particularly limited.
Examples of pigments include inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as red iron oxide (Bengara) and iron titanate; inorganic brown pigments such as γ-iron oxide; yellow iron oxide and loess Inorganic black pigments such as black iron oxide and low-order titanium oxide; inorganic purple pigments such as mango violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide and cobalt titanate; Inorganic blue pigments such as ultramarine and bitumen; Titanium oxide coated mica, titanium oxide coated bismuth oxychloride chloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, fish scale foil, etc .; talc, sericite, mica , Constitutions such as kaolin, calcium carbonate, magnesium carbonate, silicic anhydride, barium sulfate, aluminum hydroxide Fee; aluminum powder, copper powder, metal powder pigments such as gold; surface treated inorganic and metallic powder pigments; zirconium, organic pigments such as barium or aluminum lake; surface treatment organic pigments. Among these pigments, hydrophilic pigments are more preferable.
The powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, sausage, mica, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, silica Barium, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, tricalcium phosphate, calcium phosphate, fluorine apatite, hydroxyapatite, ceramic powder, bentonite, Smectite, clay, mud, metal soap (eg zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, bengara, yellow iron oxide, black iron oxide, ultramarine, bitumen, carbon black, Titanium fluoride, fine and ultrafine titanium oxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silica), mica titanium, fish scale foil, boron nitride, photochromic pigment, synthetic fluorine Various sizes and shapes of inorganic powders such as phlogopite, fine particle composite powder, gold, silver, platinum, aluminum, etc., and silicones such as hydrogen silicone and cyclic hydrogen silicone, or other silane or titanium cups Inorganic powder such as powder hydrophobized or hydrophilized by treatment with various surface treatment agents such as ring agent; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene and acrylic acid Copolymer resin powder, polyester powder, benzoguanamine resin powder Organic powders and surface-treated powders of various sizes and shapes, such as polyethylene terephthalate / polymethyl methacrylate laminate powder, polyethylene terephthalate / aluminum / epoxy laminate powder, urethane powder, silicone powder, Teflon (registered trademark) powder, etc. Organic-inorganic composite powders are preferred.
In the present invention, the pigment or powder can be, for example, 25% by mass or less, preferably 20% by mass or less, with respect to the total mass of the dispersion. The lower limit of the amount of pigment or powder is not particularly limited, but is, for example, about 0.001% by mass.
In addition, the said pigment or powder used in this invention is at least 1 type of the above-mentioned pigment group and powder group, These pigments or powder can be used individually or in combination of 2 or more types.

[Polyhydric alcohol]
The dispersion of the present invention may further contain a polyhydric alcohol. The polyhydric alcohol is a polyhydric alcohol different from the 1,2-alkanediol or 1,3-alkanediol listed above, and specific examples thereof include glycerin, propylene glycol, and polyethylene glycol. For example, polyethylene glycol having an average molecular weight of 1,000 to 4,000 can be preferably used.
In the present invention, when polyhydric alcohol is included, the blending amount thereof is, for example, 1% by mass to 60% by mass, preferably 10% by mass to 30% by mass with respect to the total mass of the obtained dispersion. it can.

[Other additives]
In the dispersion of the present invention, additives that can be generally used as cosmetic additives, quasi-drug additives, and pharmaceutical additives can be blended as necessary. As an additive component such as a physiologically active substance and a functional substance blended in a skin preparation for cosmetics, quasi-drugs or medicines, for example, an oily base, a moisturizer, a touch improver, a surfactant other than the above, Polymer, thickening / gelling agent, solvent, antioxidant, reducing agent, oxidizing agent, preservative, antibacterial agent, bactericidal agent, chelating agent, pH adjusting agent, acid, alkali, inorganic salt, UV absorber, whitening Agents, vitamins and derivatives thereof, hair growth agents, blood circulation promoters, stimulants, hormones, anti-wrinkle agents, anti-aging agents, squeeze agents, cooling sensation agents, warming sensation agents, wound healing promoters, irritation relaxation agents , Analgesic agent, cell activator, plant / animal / microbe extract, antipruritic agent, exfoliating / dissolving agent, antiperspirant, refreshing agent, astringent, enzyme, nucleic acid, fragrance, pigment, colorant, dye, anti-inflammatory agent, Anti-inflammatory agent, anti-asthma, anti-chronic obstructive pulmonary disease, anti-allergy, immunomodulator, anti Infectious diseases agents and antifungal agents.
The amount of these other additives may vary depending on the type of the additive, but is, for example, about 0.001% to 20% by mass, or about 0.01% to 10% by mass with respect to the total mass of the dispersion. can do.

Examples of oily bases include oleyl alcohol, jojoba alcohol, chimyl alcohol, ceralkyl alcohol, batyl alcohol, hexyl decanol, isostearyl alcohol, 2-octyldodecanol, dimer diol and other higher (polyhydric) alcohols; benzyl alcohol, etc. Aralkyl alcohols and derivatives thereof; isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, palmitooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexadecanoic acid, Antiisohenicosanoic acid, long-chain branched fatty acid, dimer acid, hydrogenated dimer acid, etc .; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin Ligomers, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, solid paraffin, and other hydrocarbons; candelilla wax, carnauba wax, rice wax, wood wax, beeswax, montan wax, ozokerite, ceresin Waxes such as paraffin wax, microcrystalline wax, petrolatum, Fischer-Tropsch wax, polyethylene wax, ethylene / propylene copolymer; palm oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, Tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadow foam oil, persic oil, tea tree oil, peppermint Oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cacao butter, shea butter, hydrogenated palm oil, hydrogenated castor oil, jojoba oil, hydrogenated Vegetable oils such as jojoba oil, grape seed oil, apricot oil (apricot kernel oil), camellia oil; animal fats such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle oil; whale wax, lanolin, orange Animal waxes such as luffy oil; liquid lanolin, reduced lanolin, adsorbed purified lanolin, lanolin acetate, liquid lanolin acetate, hydroxy lanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, acetic acid Lanolins such as (cetyl lanolyl) ester; cholesterol, dihydrocholesterol, la Sterols such as sterol, dihydrolanosterol, phytosterol and cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, N-lauroyl-L-glutamate di (cholesteryl / Behenyl / octyldodecyl), N-lauroyl-L-glutamate di (cholesteryl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / octyl) Dodecyl), acyl sarcosine alkyl esters such as N-lauroyl sarcosine isopropyl, cholesteryl 12-hydroxystearate, macadamia nut oil Sterol esters such as cholesteryl fatty acid, macadamia nut oil fatty acid phytosteryl, phytosteryl isostearate, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long chain branched fatty acid cholesteryl, long chain α-hydroxy fatty acid cholesteryl; phospholipid / cholesterol complex, phospholipid Lipid complexes such as lipid / phytosterol complexes; octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl palmitate, octyldodecyl palmitate, cetyl octanoate, hexyldecyl octanoate, isotridecyl isononanoate, isononanoic acid Isononyl, octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanoate, isotridecyl neopentanoate Isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, lanolin fatty acid octyldodecyl, hexyldecyl dimethyloctanoate, octyldodecyl erucate, isostearic acid hydrogenated castor oil, ethyl oleate, Avocado oil fatty acid ethyl, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, isopropyl lanolin fatty acid, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyloctyl sebacate, diisobutyl adipate, Monoalcohol carboxylic acid esters such as dioctyl succinate and triethyl citrate; lactic acid Oxyacid esters such as chill, diisostearyl malate, hydrogenated castor oil monoisostearate; glyceryl trioctanoate (glyceryl tri-2-ethylhexanoate), glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, tris (Caprylic acid / capric acid) glyceryl, tri (caprylic acid / capric acid / myristic acid / stearic acid) glyceryl, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), eicosane diacid glyceryl behenate, Trimethylolpropane trioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate, neopentyl glycol dicaprate, 2-butyl-2-ethyl-1 dioctanoate , 3-propanediol, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, ditrimethylolpropane triethylhexanoate, (isostearic acid / sebacic acid) ditrimethylolpropane, pentaerythrityl triethylhexanoate, (Hydroxystearic acid / stearic acid / rosinic acid) dipentaerythrityl, diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl nonaisostearate-10, deca (erucic acid / isostearic acid / ricinoleic acid) polyglyceryl-8, (hexyldecanoic acid / sebacin) Acid) diglyceryl oligoester, glycol distearate (ethylene glycol distearate), dineopentanoic acid 3 Polyhydric alcohol fatty acid esters such as methyl-1,5-pentanediol and dineopentanoic acid 2,4-diethyl-1,5-pentanediol; diisopropyl linoleic acid diisopropyl, dimer linoleic acid diisostearyl, dimer linoleic acid Di (isostearyl / phytosteryl), dimer dilinoleic acid (phytosteryl / behenyl), dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl), dimer dilinoleate dimer dilinoleyl, diiso stearic acid dimer dilinoleyl Dimer linoleyl hydrogenated rosin condensate, dimer linoleic acid hydrogenated castor oil, dimer acid or dimer diol derivative such as hydroxyalkyl dimer linoleyl ether; coconut oil fatty acid monoeta Uramide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide Fatty acid alkanolamides such as (partamido MEA), palmitic acid diethanolamide (partamide DEA), coconut oil fatty acid methylethanolamide (cocamidomethyl MEA); dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclo Methicon (cyclic dimethylsiloxane, decamethylcyclopentasiloxane (also called simply cyclopentasiloxane)), phenyltrimethicone, dipheny Amino-modified silicones such as rubimethicone, phenyldimethicone, stearoxypropyldimethylamine, (aminoethylaminopropylmethicone / dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, aminopropyldimethicone and amodimethicone, cation-modified silicone , Polyether modified silicone such as dimethicone copolyol, polyglycerin modified silicone, sugar modified silicone, carboxylic acid modified silicone, phosphoric acid modified silicone, sulfuric acid modified silicone, alkyl modified silicone, fatty acid modified silicone, alkyl ether modified silicone, amino acid modified silicone , Peptide-modified silicone, fluorine-modified silicone, cation-modified and polyether-modified silicone, Non-modified and polyether-modified silicones, alkyl-modified and polyether-modified silicones, silicones such as polysiloxane / oxyalkylene copolymers; fluorine-based oils such as perfluorodecane, perfluorooctane, and perfluoropolyether are preferred. It is mentioned as a thing.

Examples of moisturizers / feel improvers include glycerin, trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol / propylene glycol copolymer and the like polyols and Polymers; glycol alkyl ethers such as diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether; (eicosane diacid / tetradecanedioic acid) polyglyceryl-10, tetradecane Water-soluble esters such as polyglyceryl-10; sorbitol, xylitol, erythritol, man Sugar alcohols such as tol and maltitol; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α -, Β-, γ-cyclodextrin and modified cyclodextrins such as maltosylation, hydroxyalkylation, etc.), β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabinogalactan, dextrin, dextran, glycogen, ethyl Sugars such as glucoside, glucosylethyl methacrylate polymer or copolymer, and derivatives thereof; hyaluronic acid, sodium hyaluronate; chondroitin sulfate sodium; mucoichi Sulfate, caronine sulfate, keratosulfate, dermatan sulfate; white jellyfish extract, white jellyfish polysaccharide; fucoidan; tuberose polysaccharide or naturally derived polysaccharide; organic acids such as citric acid, tartaric acid, lactic acid and their salts; urea and its derivatives; 2-pyrrolidone-5-carboxylic acid and salts thereof such as sodium; betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, Amino acids such as asparagine, aspartic acid, cysteine, cysteine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine and their salts; collagen, fish-derived collagen, atelocollagen, gelatin , Elastin, collagenolytic peptide, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastinolytic peptide, keratinolytic peptide, hydrolyzed keratin, conchiolinolytic peptide, hydrolyzed conchioline, silk proteolytic peptide, hydrolyzed silk, lauroyl hydrolyzed Degraded silk sodium, soybean proteolytic peptide, wheat proteolytic peptide, hydrolyzed wheat protein, casein degrading peptide, acylated peptide and other protein peptides and derivatives thereof; acylation of palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide, etc. Peptides; Silylated peptides; Lactic acid bacteria culture, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesameignan glycoside, glutathione, Albumin, whey; choline chloride, phosphorylcholine; placenta extract, aerostin, collagen, aloe extract, hamamelis water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, Izayoi rose extract, yarrow extract, eucalyptus extract Ceramides, such as animal and plant extract components such as merirot extract, natural ceramide (types 1, 2, 3, 4, 5, 6), hydroxyceramide, pseudoceramide, glycosphingolipid, ceramide and sugar ceramide-containing extract It is mentioned as preferable.

Preferred examples of the surfactant include an anionic surfactant, a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and a polymer surfactant. Examples of preferable surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfate esters such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; Polyoxyethylene alkyl sulfates such as sodium laureth sulfate and triethanolamine laureth sulfate; cocoyl methyl taurine sodium, cocoyl methyl taurine potassium, lauroyl methyl taurine sodium, myristoyl methyl taurine sodium, lauroyl methyl alanine sodium, lauroyl sarcosine sodium, lauroyl sarcosine tri Acyl N-methyl amino acid salts such as ethanolamine and sodium methylalanine lauroylglutamate; cocoyl Acyl amino acid salts such as sodium glutamate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, cocoylalanine triethanolamine; polyoxyethylene alkyl ethers such as sodium laureth acetate Acetic acid salt; Succinic acid ester salt such as sodium lauroyl monoethanolamide succinate; Fatty acid alkanolamide ether carboxylate; Acyl lactate; Polyoxyethylene fatty amine sulfate; Fatty acid alkanolamide sulfate; Hardened coconut oil fatty acid sodium glyceryl sulfate Fatty acid glyceride sulfate such as alkylbenzene polyoxyethylene sulfate; α-olefin Olefin sulfonates such as sodium sulfonic acid sulfonate; Alkyl sulfosuccinates such as disodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate; disodium laureth sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene sodium sodium sulfosuccinate, lauryl polypropylene glycol sulfosuccinic acid Alkyl ether sulfosuccinates such as sodium; alkylbenzene sulfonates such as sodium tetradecylbenzenesulfonate and triethanolamine tetradecylbenzenesulfonate; alkylnaphthalenesulfonates; alkanesulfonates; α-sulfo fatty acid methyl ester salts; Acyl isethionate; alkyl glycidyl ether sulfonate; alkyl sulfoacetate; laureth Alkyl ether phosphate salts such as sodium phosphate, sodium dilaureth phosphate, sodium trilaureth phosphate, sodium monooles phosphate; alkyl phosphate ester salts such as potassium lauryl phosphate; sodium caseinate; alkyl aryl ether phosphate; fatty acid amide Ether phosphates; Phospholipids such as phosphatidylglycerol, phosphatidylinositol, and phosphatidic acid; Silicone anionic surfactants such as carboxylic acid-modified silicone, phosphoric acid-modified silicone, and sulfuric acid-modified silicone; Nonionic surfactants These include laureth (polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steareth (polyoxyethylene stearyl ether), behenez (polyoxy). Polyoxyethylene alkyl ethers with various polyoxyethylene addition numbers such as silethylene behenyl ethers), isosteares (polyoxyethylene isostearyl ether) s, octyldecesses (polyoxyethylene octyldodecyl ethers); Ether: Polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearic acid diester Castor oil and hardened castor oil derivatives such as polyoxyethylene hydrogenated castor oil maleic acid; polyoxyethylene phytosterol; polyoxyethylene cholesterol Polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene / polyoxypropylene cetyl ether, polyoxyethylene / polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene / polyoxypropylene monobutyl ether Polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene glycerin ether and other polyoxyethylene / polyoxypropylene alkyl ethers; polyoxyethylene / polyoxypropylene glycol; PPG-9 diglyceryl and the like ( Poly) glycerin polyoxypropylene glycol; glyceryl stearate, glyceryl isostearate, glyceryl palmitate, milli Glyceryl fatty acid partial esters such as glyceryl tinate, glyceryl oleate, glyceryl coconut oil fatty acid glyceryl, mono-cotton oil fatty acid glycerin, glyceryl monoerucate, glyceryl sesquioleate, glycerin α, α'-oleic acid pyroglutamate, glyceryl monostearate Polyglyceryl stearate-2, 3, 4, 5, 6, 8, 10, 10 polyglyceryl-6 distearate, 10, polyglyceryl tristearate, polyglyceryl decastearate-10, isostearin Polyglyceryl-2, 3, 4, 5, 6, 8, 10, diisostearate polyglyceryl-2 (diglyceryl diisostearate), 3, 10, polyglyceryl-2 triisostearate, tetraisostearate Polyglyceryl-2, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, 3, 4, 5, 6, 8, 10, dioleate polyglyceryl-6, trioleate polyglyceryl-2, dekaoleic acid Polyglyceryl fatty acid esters such as polyglyceryl-10; ethylene glycol monofatty acid esters such as ethylene glycol monostearate; propylene glycol monofatty acid esters such as propylene glycol monostearate; pentaerythritol partial fatty acid esters; sorbitol partial fatty acid esters; maltitol moieties Fatty acid ester; maltitol ether; sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbi Monostearate, sorbitan sesquioleate, sorbitan trioleate, penta-2-ethylhexyl diglycerol sorbitan, tetra-2-ethylhexyl diglycerol sorbitan, etc .; sucrose fatty acid ester, methyl glucoside fatty acid ester, undecylene Sugar derivative partial ester such as acid trehalose; alkyl glucoside such as caprylyl glucoside; alkyl polyglycoside; lanolin alcohol; reduced lanolin; polyoxyethylene distearate, polytylene glycol diisostearate, polyoxyethylene monooleate, poly Polyoxyethylene fatty acid mono- and diesters such as oxyethylene dioleate; polyoxyethylene propylene glycol fatty acid ester; Polyoxyethylene glycerol fatty acid esters such as polyoxyethylene monooleate such as xylethylene glycerol monostearate, polyoxyethylene glycerol monoisostearate, polyoxyethylene glycerol triisostearate; polyoxyethylene sorbitan monooleate, poly Polyoxyethylene sorbitan fatty acid esters such as oxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol Polyoxyethylene sorbitol such as pentaoleate and polyoxyethylene sorbitol monostearate Fatty acid ester; Polyoxyethylene methyl glucoside fatty acid ester; Polyoxyethylene alkyl ether fatty acid ester; Polyoxyethylene animal and vegetable fats and oils such as polyoxyethylene sorbitol beeswax; Isostearyl glyceryl ether, Kimyl alcohol, Serakyl alcohol, Batyl alcohol, etc. Polyglyceryl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponins and sophorolipids; polyoxyethylene fatty acid amides; Palm oil fatty acid monoethanolamide (cocamide MEA), palm oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (Lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), palm oil fatty acid methylethanolamide ( Fatty acid alkanolamides such as cocamidomethyl MEA); alkyldimethylamine oxides such as lauramine oxide, cocamamine oxide, stearamine oxide, and behenamine oxide; alkylethoxydimethylamine oxide; polyoxyethylene alkyl mercaptan; dimethicone copolyol, etc. Polyether-modified silicone, polysiloxane / oxyalkylene copolymer, polyglycerin-modified silicone, sugar-modified silicone, etc. Nonionic surfactants of silicone, etc .; cationic surfactants include alkyltrimethylammonium chlorides such as behentrimonium chloride, steartrimonium chloride, cetrimonium chloride, lauryltrimonium chloride; stearyltrimonium bromide, etc. Alkyltrimethylammonium bromides; dialkyldimethylammonium chlorides such as distearyldimonium chloride and dicocodimonium chloride; fatty acid amidoamines and salts thereof such as stearamidepropyldimethylamine and stearamideethyldiethylamine; alkyl ethers such as stearoxypropyldimethylamine Amines and salts or quaternary salts thereof; ethyl sulfate long chain branched fatty acid (12-31) aminopropylethyldimethylammonium Fatty acid amide type quaternary ammonium salts such as lanolin fatty acid aminopropylethyldimethylammonium; polyoxyethylene alkylamines and salts or quaternary salts thereof; alkylamine salts; fatty acid amidoguanidinium salts; alkyl etheraminemonium salts; Benzalkonium salts; benzethonium salts; pyridinium salts such as cetylpyridinium chloride; imidazolinium salts; alkylisoquinolinium salts; dialkyl morpholinium salts; polyamine fatty acid derivatives; aminopropyl dimethicone and amodimethicone, etc. Silicone-based cationic surfactants such as amino-modified silicone, cation-modified silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone Examples of the amphoteric surfactant; etc
N-alkyl-N, N-dimethylamino acid betaines such as lauryl betaine (lauryldimethylaminoacetic acid betaine); fatty acid amide alkyl-N, N-dimethylamino acid betaines such as cocamidopropyl betaine and lauramidopropyl betaine; sodium cocoamphoacetate; Imidazoline-type betaines such as sodium lauroamphoacetate; alkylsulfobetaines such as alkyldimethyltaurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate; phosphate-type betaines such as alkyldimethylaminoethanol phosphate; phosphatidylcholine, phosphatidylethanolamine, Sphingophospholipids such as phosphatidylserine and sphingomyelin, lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogen Egg yolk phospholipids, partially hydrogenated egg yolk phospholipids, phospholipids such as hydroxylated lecithin; silicone-based amphoteric surfactants; polymer surfactants include polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, acrylic acid -Alkyl methacrylate copolymers; various silicone surfactants are preferred.

Polymers, thickeners and gelling agents include guar gum, locust bean gum, queens seed, carrageenan, galactan, arabic gum, tara gum, tamarind, far selelain, karaya gum, troarooi, cara gum, tragacanth gum, pectin, pectic acid and sodium Salt such as salt, salt such as alginic acid and sodium salt, mannan; starch such as rice, corn, potato, wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salt, xanthan gum, pullulan, gellan gum, chitin , Chitosan, agar, gypsophila extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypro Cellulose, hydroxypropylmethylcellulose, carboxymethylcellulose and salts thereof such as sodium, methylhydroxypropylcellulose, sodium cellulose sulfate, cellulose dialkyldimethylammonium sulfate, crystalline cellulose, cellulose powder such as cellulose powder; soluble starch, carboxymethyl starch, Starch polymers such as methylhydroxypropyl starch and methyl starch, starch derivatives such as hydroxypropyltrimonium chloride, octenyl succinate corn starch and aluminum; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP) and polyvinyl Alcohol (PVA), vinyl pydridone, vinyl alcohol Coal copolymer, polyvinyl methyl ether; polyethylene glycol, polypropylene glycol, polyoxyethylene / polyoxypropylene copolymer; (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, (acrylates / stearyl acrylate / ethylamine methacrylate oxide) ) Amphoteric methacrylate copolymers such as copolymers; (dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; polyvinyl acetate partial saponified product , Maleic acid copolymer; vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; poly Esters, water dispersible polyesters; polyacrylamides; polyacrylic acid ester copolymers such as polyethyl acrylate, carboxyvinyl polymers, salts of polyacrylic acid and its sodium salts, acrylic acid / methacrylic acid ester copolymers; Acrylic acid / alkyl methacrylate copolymer; cationic cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, and acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaternium-22 Acrylic acid / diallyldimethylammonium chloride / acrylamide copolymer, acrylic acid / cationized methacrylic acid ester copolymer, acrylic acid / cationized meta-acrylate, etc. Acrylic acid / methyl acrylate / methacrylamidopropyltrimethylammonium chloride copolymer such as polyquaternium-47, methacrylic acid choline ester polymer; cationized oligosaccharide, cationized dextran, guar hydroxypropyltri Cationic polysaccharides such as monium chloride; polyethyleneimine; cationic polymers; copolymers of 2-methacryloyloxyethyl phosphorylcholine such as polyquaternium-51 and copolymers of butyl methacrylate; acrylic resin emulsion, polyacrylic acid Polymer emulsions such as ethyl emulsion, polyacrylic alkyl ester emulsion, polyvinyl acetate resin emulsion, natural rubber latex, synthetic latex; nitrocellulose; Tans and various copolymers; Various silicones; Various silicone-based copolymers such as acrylic-silicone graft copolymers; Various fluoropolymers; 12-hydroxystearic acid and its salts; Dextrin palmitate and dextrin myristate Dextrin fatty acid esters such as silicic anhydride, fumed silica (ultrafine silicic anhydride), magnesium aluminum silicate, sodium magnesium silicate, metal soap, metal dialkyl phosphate, bentonite, hectorite, organically modified clay mineral, Preferred examples include sucrose fatty acid esters and fructooligosaccharide fatty acid esters. Among the examples, cellulose and derivatives thereof, alginic acid and salts thereof, polyvinyl alcohol, hyaluronic acid and salts thereof, or collagen is preferable.

Solvents include lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol and isobutyl alcohol; glycols such as propylene glycol, diethylene glycol, dipropylene glycol and isopentyl diol; diethylene glycol monoethyl ether (ethoxydiglycol) , Glycol ethers such as ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether; ethylene glycol monoethyl ether Acetate, diethylene glycol Glycol ether esters such as ethyl ether acetate and propylene glycol monoethyl ether acetate; glycol esters such as diethoxyethyl succinate and ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, acetic acid Preferred examples include ethyl, N-methylpyrrolidone and toluene.

Antioxidants include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or derivatives thereof; erythorbic acid and derivatives thereof; Preferred are sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride As mentioned.

Preferred examples of the reducing agent include thioglycolic acid, cysteine, cysteamine and the like.

Preferred examples of the oxidizing agent include hydrogen peroxide water, ammonium persulfate, sodium bromate, percarbonate, and the like.

Examples of preservatives, antibacterial agents, and bactericides include hydroxybenzoic acid such as methylparaben, ethylparaben, propylparaben, and butylparaben, and salts or esters thereof; salicylic acid; sodium benzoate; phenoxyethanol; methylchloroisothiazolinone, methylisothiazo Isothiazolinone derivatives such as linone; imidazolinium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzalkonium chloride, chloride Benzethonium, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, hinokitiol; phenol, isopropylphenol, cresol, Mall, para chlorophenol, phenylphenol, other phenols such as phenylphenol sodium; phenylethyl alcohol, photosensitive Motorui, be mentioned as antibacterial zeolite, silver ion.

Examples of chelating agents include edetate (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; Phosphonic acid and its sodium salt; polyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine, gluconic acid, Ascorbic acid, succinic acid and tartaric acid are preferred.

pH adjusters / acids / alkalis include ascorbic acid, citric acid, sodium citrate, lactic acid, sodium lactate, potassium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, Hydrochloric acid, sulfuric acid, monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propane Preferred examples include diol, arginine, sodium hydroxide, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate.

Inorganic salts include sodium chloride-containing salts such as salt, common salt, rock salt, sea salt, natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, Aluminum sulfate / potassium sulfate (alum), aluminum sulfate / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na, 2Na and 3Na phosphates, phosphoric acid Potassium, calcium phosphates and magnesium phosphates are preferred.

Examples of ultraviolet absorbers include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, and N, N-dimethylparaaminobenzoic acid ethyl ester. Benzoic acid ultraviolet absorbers such as esters, N, N-dimethylparaaminobenzoic acid butyl ester, N, N-dimethylparaaminobenzoic acid methyl ester; Anthranilic acid ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; Salicylic acid And salicylic acid systems such as sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate External line absorbent: octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p- Methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-ethylhexyl-p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (sinoxate) Cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate (octocrine), glyceryl mono-2-ethylhexanoyl-diparame Cinnamic acid UV absorbers such as toxicinnamate, ferulic acid and derivatives thereof; 2,4-dihydroxybenzophenone, 2,2′-dihydroxy-4-methoxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxy Benzophenone, 2,2 ′, 4,4′-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4′-methylbenzophenone, 2-hydroxy-4- Methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4′-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone Benzofe etc. UV absorbers; 3- (4′-methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2′-hydroxy- 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole; 2- (2′-hydroxy-5′-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyl triazone; urocanic acid such as urocanic acid and ethyl urocanate Derivatives; 2- (2′-hydroxy-5′-methylphenyl) benzotriazole Hydantoin derivatives such as 1- (3,4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentanedione, dimethoxybenzylidenedioxoimidazolidinepropionate 2-ethylhexyl, phenylbenzimidazolazolesulfonic acid, terephthalate Preference is given to liridene dicamphorsulfonic acid, drometrizol trisiloxane, methyl anthranilate, rutin and its derivatives, oryzanol and its derivatives.

Examples of whitening agents include hydroquinone glycosides such as arbutin and α-arbutin and their esters; ascorbic acid phosphates such as ascorbic acid, sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate, ascorbic acid Ascorbic acid fatty acid esters such as tetraisopalmitic acid ester, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucosides such as ascorbic acid-2-glucoside and fatty acid esters thereof, ascorbic acid sulfate ester, tocopheryl ascorbyl phosphate Ascorbic acid derivatives such as kojic acid, ellagic acid, tranexamic acid and its derivatives, ferulic acid and its derivatives, placenta extract, glutathione, oryzanol, butylreso Shinoru, oil-soluble Kamomiraekisu, oil-soluble licorice extract, Nishikawa willow extract, be mentioned as saxifrage extract, and the like plant extracts are preferred.

Vitamins and their derivatives include vitamin A such as retinol, retinol acetate, retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, Flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid such as nicotinic acid amide / benzyl nicotinate, vitamin B group such as choline; vitamin C such as ascorbic acid and its sodium salt; vitamin D; α, Vitamin E such as β, γ, and δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphates such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt, Ascorbic acid fatty acid esters such as ascorbyl tetraisopalmitate, ascorbyl stearate, ascorbyl palmitate and ascorbyl dipalmitate, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucosides such as ascorbic acid-2-glucoside and Ascorbic acid derivatives such as fatty acid esters and tocopheryl phosphate ascorbyl; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol acetate, tocopherol linoleate, tocopherol phosphate, tocopherol phosphate etc., tocotrienol, and other various vitamin derivatives Is preferable.

Plant extracts and tinctures such as assembly extract, red pepper tincture, ginger tincture, ginger extract, cantalis tincture; capsaicin, nonylic acid vanillylamide, gingeron, ictamol, tannic acid Borneol, cyclandrate, cinnarizine, trazoline, acetylcholine, verapamil, cephalanthin, γ-oryzanol, vitamin E and derivatives such as tocopherol / nicotinic acid tocopherol, γ-oryzanol, nicotinic acid, nicotinic acid amide, nicotinic acid benzyl ester, Inositol hexanicotinate, derivatives such as nicotine alcohol, allantoin, photosensitive element 301, photosensitive element 401, capronium chloride, pentadecanoic acid monoglyceride, flavonol Derivatives, stigmasterol or stigmasterol and its glycosides, and minoxidil are preferred.

Preferred examples of hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like. Other remedies such as anti-wrinkle agents, anti-aging agents, squeeze agents, cooling sensations, warming sensation agents, wound healing promoters, irritation relievers, analgesics, cell activators include retinols, retinoic acids, retinoin Acid tocopheryl; derivatives such as lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and glycosides / esterified products thereof, α- or such as hydroxycapric acid, long chain α-hydroxy fatty acid, long chain α-hydroxy fatty acid cholesteryl β-hydroxy acids and derivatives thereof; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosines; caffeine, xanthine and the like; coenzyme Q10, carotene, lycopene , Astaxanthin, lutein, α-lipoic acid, platinum nanocolloid, fullerenes, etc. Antioxidant / active oxygen scavengers; catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamin, protoanthocyanidin, chlorogenic acid, apple polyphenol; rutin and glycosides, etc. Derivatives of hesperidin and glycosides; lignan glycosides; licorice extract-related substances such as grabrizine, glabrene, liquiritin and isoliquiritin; lactoferrin; shogaol, gingerol; fragrance substances such as menthol and cedrol and their derivatives; capsaicin And insecticides such as diethyl toluamide; complexes of physiologically active substances and cyclodextrins are preferred.

Plant / animal / microbe extracts include iris extract, ashitaba extract, asunalo extract, asparagus extract, avocado extract, achacha extract, almond extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo biloba extract , Chinchilla extract, fennel extract, ginseng extract, turmeric extract, oolong tea extract, walnut extract, ages extract, echinacea leaf extract, enme extract, gonon extract, duckweed extract, pollen extract, barley extract, ginseng extract, hypericum extract , Nettle extract, onionis extract, Dutch mustard extract, orange extract, dried sea water, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, water Dehydrated wheat powder, hydrolyzed silk, cocoon extract, chamomile extract, oil-soluble chamomile extract, carrot extract, cormorant mugwort extract, oat extract, calcade extract, licorice extract, oil-soluble licorice extract, kiwi extract, kiou extract, jellyfish extract, quina extract, cucumber Extract, Giri Leaf Extract, Guanosine, Guava Extract, Kujin Extract, Gardenia Extract, Kumazasa Extract, Clara Extract, Walnut Extract, Chestnut Extract, Grapefruit Extract, Clematis Extract, Black Rice Extract, Brown Sugar Extract, Black Vinegar, Chlorella Extract, Mulberry Extract, Gentian Extract, Gennoshoco extract, Black tea extract, Yeast extract, Koboku extract, Coffee extract, Burdock extract, Rice extract, Rice fermented extract, Rice bran extract, Rice germ , Comfrey extract, Collagen, Cowberry extract, Saishin extract, Psycho extract, Saitai extract, Saffron extract, Salvia extract, Salmon extract, Sasa extract, Hawthorn extract, Sansha extract, Salamander extract, Shiitake extract, Giant extract, Shikon extract, Perilla extract , Linden extract, citrus extract, jatoba extract, peony extract, ginger cucumber extract, ginger root extract, birch extract, white jellyfish extract, horse chestnut extract, stevia extract, stevia fermented product, Nishikawa willow extract, horseshoe extract, hawthorn extract, elderberry Extract, yarrow extract, mint extract, sage extract, mallow extract, nematode extract, essence extract, sedge extract , Diou extract, Soybean extract, Tisoiso extract, Thyme extract, Dandelion extract, Lichen extract, Tea extract, Clove extract, Chigaya extract, Chimpi extract, Tea tree oil, Chacha tea extract, Capsicum extract, Toki extract, Tokinen extract, Tonin extract, Spruce extract, Dokudami Extract, Tomato Extract, Natto Extract, Carrot Extract, Garlic Extract, Novara Extract, Hibiscus Extract, Bacmond Extract, Lotus Extract, Parsley Extract, Birch Extract, Honey, Hamamelis Extract, Parietalia Extract, Hikikoshi Extract, Bisabolol, Cypress Extract, Bifidobacteria extract, loquat extract, Japanese dandelion extract, Japanese cypress extract, Bukkuri extract, Butcher bloom extract, grape extract, grape seed extract, pro Squirrel, loofah extract, safflower extract, peppermint extract, body sage extract, button extract, hop extract, squirrel squid extract, pine extract, maroonnier extract, citrus extract, sorghum extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, yukinoshita Extract, Yuzu Extract, Lily Extract, Yakuinin Extract, Artemisia Extract, Lavender Extract, Green Tea Extract, Eggshell Membrane Extract, Apple Extract, Rooibos Tea Extract, Ganoderma Extract, Lettuce Extract, Lemon Extract, Forsythia Extract, Forsythia Extract, Rose Extract, Rosemary Extract , Extracts such as Roman chamomile extract, royal jelly extract, and bitumen extract are preferable.

Examples of antipruritic agents include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor, and the like.

Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine and the like.

Examples of antiperspirants include chlorohydroxyaluminum, aluminum chloride, zinc oxide, zinc paraphenol sulfonate, and the like.

Examples of the refreshing agent include menthol and methyl salicylate.

Examples of astringents include citric acid, tartaric acid, lactic acid, aluminum sulfate / potassium, and tannic acid.

Enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, and the like.

Preferred nucleic acids include ribonucleic acid and its salts, deoxyribonucleic acid and its salts, and adenosine triphosphate disodium.

As perfumes, acetyl cedrene, amylcinnamaldehyde, allyl amyl glycolate, β-ionone, iso-Esuper, isobutyl quinoline, Iris oil, Iron, indole, ylang ylang oil, undecanal, undecenal, γ-undecalactone, Estragole, eugenol, oak moss, opoponax resinoid, orange oil, eugenol, auranthiol, galac solid, carvacrol, L-carvone, camphor, cannon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile , Isobornyl acetate, geranyl acetate, dimethylbenzyl carvinyl acetate, styraryl acetate, cedolyl acetate, terpinel acetate, pt-butylcyclohexyl acetate, vetiberyl acetate, benzyl acetate Linalyl acetate, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromyrsenol, jasmine absolute, jasmine lactone, cis-jasmon, citral, citronenol, Citronellal, cinnamon bark oil, 1,8-cineole, cinnamaldehyde, stylus resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascon, damasenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ- Terpinene, triplar, nerol, nonanal, 2,6-nonadienol, nonalactone, patchouli alcohol, vanilla Solute, vanillin, basil oil, patchouli oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitglen oil, hexylcinnamaldehyde, cis-3-hexenol, perubalsum, vetiver oil, vetiverol, peppermint oil , Pepper oil, heliotropin, bergamot oil, benzylbenzoate, borneol, milresinoid, musk ketone, methylnonylacetaldehyde, γ-methylyonone, menthol, L-menthol, L-menton, eucalyptus oil, β-yonone, lime oil, lavender oil Synthetic and natural flavors such as D-limonene, linalool, linal, rillial, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, and various essential oils In addition, various kinds of blended fragrances are preferable.

As pigments / colorants / dyes, brown 201, black 401, purple 201, purple 401, blue 1, blue 2, blue 201, blue 202, blue 203, blue 204, blue 205, Blue 403, Blue 404, Green 201, Green 202, Green 204, Green 205, Green 3, Green 401, Green 402, Red 102, Red 104-1, Red 105-1, Red 106, Red 2, Red 201, Red 202, Red 203, Red 204, Red 205, Red 206, Red 207, Red 208, Red 213, Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228, Red 230-1 Red 230-2, Red 231, Red 232, Red 3, Red 401, Red 404, Red 404, Red 405, Red 501, Red 502, Red 503, Red 504, Red 505 Red No. 506, Orange No. 201, Orange No. 203, Orange No. 204, Orange No. 205, Orange No. 206, Orange No. 207, Orange No. 401, Orange No. 402, Orange No. 403, Yellow No. 201, Yellow No. 202-1 Yellow 202-2, Yellow 203, Yellow 204, Yellow 205, Yellow 4, Yellow 401, Yellow 402, Yellow 403-1, Yellow 404, Yellow 405, Yellow 406, Yellow Legal pigments such as No. 407 and Yellow No. 5; Other acidic dyes such as Acid Red 14; Aryanor Sienna Brown, Aryanor Madder Red, Ari Basic dyes such as nor Steel Blue, Aryanor Straw Yellow, etc .; HC Yellow 2, HC Yellow 5, HC Red 3, 4-hydroxypropylamino-3-Ntrobisphenol, N, N'-bis (2-hydroxyethyl-2) Nitro dyes such as phenylenediamine, HC Blue 2, Basic Blue 26; disperse dyes; anthraquinones such as astaxanthin and alizarin, anthocyanidins, β-carotene, catenal, capsanthin, chalcone, calsamine, quercetin, crocin, chlorophyll, curcumin, cochineal, cochineal Naphthoquinones such as bixin, flavones, betacyanidine, henna, hemoglobin Natural pigments and dyes such as glycine, lycopene, riboflavin and rutin; p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylenediamine, 5-amino-2- Preferable examples include oxidative dye intermediates and couplers such as methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine, and salts thereof; auto-oxidative dyes such as indoline; and dihydroxyacetone.

Anti-inflammatory / anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, ketoprofen, ibuprofen, diclofenac, loxoprofen, celecoxib, infliximab, etanercept, zinc oxide, hydroacetic acid, zinc acetate, Preferred examples include prednisone, diphedramine hydrochloride, chlorpheniramine maleate; and plant extracts such as peach leaf extract and persimmon leaf extract.

Anti-asthma, anti-chronic obstructive pulmonary disease, anti-allergy, immunomodulators include aminophylline, theophylline, steroids (fluticasone, beclomethasone, etc.), leukotriene antagonists, thromboxane inhibitors, intal, β2-stimulant (Formoterol, salmeterol, albuterol, tulobuterol, clenbuterol, epinephrine, etc.), tiotropium, ipratropium, dextromethorphan, dimemorphan, bromhexine, tranilast, ketotifen, azelastine, cetirizine, chlorpheniramine, polyquitolsine, Preferred examples include cytokine regulators, interferons, omalizumab, and protein / antibody preparations.

Preferred examples of the anti-infective and antifungal agents include oseltamivir, zanamivir, and itraconazole. In addition to these, cosmetic raw material standards, cosmetic ingredient-specific combination ingredient standards, Japan Cosmetic Industry Association ingredient display name list, INCI dictionary (The International Cosmetic Ingredients and Handbooks), quasi-drug ingredients standards, Japanese pharmacopoeia, pharmaceutical additive standards Ingredients listed in the Food Addendum, etc., and the international patent classification IPC described in Japan and other foreign patent gazettes and patent publications (including publications and republications) belonging to the A61K7 and A61K8 classifications It is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., in known combinations, blending ratios and blending amounts.

[Method for producing dispersion]
The dispersion of the present invention is a pigment or powder dispersant comprising a lipid peptide compound comprising at least one of the compounds represented by the formulas (1) to (3) or a pharmaceutically usable salt thereof. And at least one selected from the group consisting of surfactants, water, 1,2-alkanediols or 1,3-alkanediols, fatty acids, pigments and powders, and optionally other additives such as polyhydric alcohols These are mixed and stirred with heating, and then stirred and cooled to about room temperature.

For example, the dispersion of the present invention is produced by the following process as an example.
a) a step of blending the above-mentioned pigment or powder dispersant (lipid peptide compound), a surfactant, and water, and heating to prepare a solution (or dispersion);
b) adding the solution (or dispersion) to water and heating at a temperature of room temperature to less than 100 ° C .;
c) A step of cooling with stirring until the temperature is lower than the temperature in the heating step to obtain the dispersion of the present invention.
Here, at least one selected from the group consisting of 1,2-alkanediol or 1,3-alkanediol, fatty acid, and pigment and powder, and the other components are the solution (or dispersion) in step a). It may be added in the preparation step, or may be added in advance to the water to which the solution (or dispersion) is added in step b).
Further, water is 60% by mass or more and 99.9% by mass or less based on the total mass of the dispersion liquid (including at least one selected from the group consisting of pigment and powder) of the present invention thus obtained. preferable.

The heating temperature in the step a) and the step b) is preferably 50 ° C. to 90 ° C., more preferably 60 ° C. to 90 ° C., for example 80 ° C., and stirring is preferably performed while heating. The heating and stirring time in each step at this time varies depending on the pigment or powder dispersant (lipid peptide compound) used, the type of the surfactant and other components, and the blending amount thereof, but usually from 1 minute to 50 minutes. It can be dissolved and dispersed in about minutes.
Following steps a) and b), cooling is performed with stirring until the liquid temperature is lower than the temperature in step b) (step c). Here, the cooling temperature is, for example, room temperature to 80 ° C., room temperature to 60 ° C., or room temperature to 40 ° C.

Moreover, after manufacturing the aqueous composition which is a premix, the dispersion liquid of this invention can also be manufactured by adding another compounding component to this premix suitably.
For example, the following is mentioned as a manufacturing method of the dispersion liquid which passed through the premix.
1) Step for preparing premix 1-1) Surfactant and water, pigment or powder dispersant (compound represented by the above formulas (1) to (3) or pharmaceutically usable thereof) A heating step of heating a mixed system comprising a lipid peptide-type compound comprising at least one of salts) to a temperature of room temperature to less than 100 ° C.,
1-2) Subsequently, a step of appropriately adding 1,2-alkanediol or 1,3-alkanediol, fatty acid and other additives to the heated mixed system,
1-3) A preparation step of cooling the solution or dispersion to obtain an aqueous composition (premix),
2) Step of producing dispersion using premix 2-1) The aqueous composition (premix) heated to a temperature of room temperature to less than 100 ° C. in an aqueous phase heated to a temperature of room temperature to less than 100 ° C. Add the water phase heated to a temperature of room temperature to less than 100 ° C. and mix with the aqueous composition (premix) heated to a temperature of room temperature to less than 100 ° C. Process,
2-2) A cooling step in which the mixture obtained in the mixing step is stirred and cooled to obtain a dispersion.
The aqueous phase in the above step 2-1) contains water, may further contain higher alcohols and pigments, and may contain 1,2-alkanediol or 1,3-alkanediol, fatty acids, and other additives. . Further, in 2-1), a pigment and other additives may be mixed with the aqueous composition (premix) and then combined with the aqueous phase.
Furthermore, in the mixing step, a dispersion (preparation) to which a drug is added can also be produced by adding a drug solution.

The heating temperature of the mixed system (and aqueous composition) in the steps 1-1) and 1-2) is preferably 50 ° C. to 90 ° C., more preferably 60 ° C. to 90 ° C., for example 70 ° C., or 80 ° C. It is. This step is preferably carried out with stirring. The heating (stirring) time in each step at this time varies depending on the types of pigments, powder dispersants (lipid peptide compounds), surfactants and other components contained in the aqueous composition, and the blending amount thereof. Usually, about 5 to 50 minutes. By this step, the aqueous composition is uniformly dissolved.
The cooling temperature in the step 1-3) is, for example, room temperature to 80 ° C., room temperature to 60 ° C., or room temperature to 40 ° C. In this step, it is more preferable to cool with stirring, and then stop stirring and leave still.
In addition, it is preferable that water is 30 mass% or more and less than 80 mass% with respect to the total mass of the aqueous composition (premix) obtained by the 1) process.

In the step 2-1), the heating temperature of the aqueous phase and the aqueous composition (premix) is preferably 50 ° C. to 90 ° C., more preferably 60 ° C. to 90 ° C., such as 70 ° C., or 80 ° C., or 90 ° C. It is. The aqueous phase is preferably heated with stirring because it contains other components, and it is usually preferred to carry out heating (stirring) for about 1 to 50 minutes until the contained components are uniformly dissolved and dispersed. The heating temperature of the aqueous phase may be the same as the heating temperature of the aqueous composition (premix).

Subsequently, in the step 2-2), the mixture obtained in the previous step is stirred and cooled to obtain a dispersion. When cooling with stirring, for example, stirring may be performed until the cooling temperature reaches room temperature to 80 ° C., room temperature to 60 ° C., for example, about 60 ° C., and then stirring may be stopped and allowed to stand and cool.

Thus, also in the obtained dispersion using the aqueous composition (premix), the blending amount of water is preferably 60% by mass or more and 99.9% by mass or less with respect to the total mass of the dispersion.

Hereinafter, the present invention will be described in detail by way of examples and test examples, but the present invention is not limited to these examples.

[Synthesis Example 1: Synthesis of lipid peptide (N-palmitoyl-Gly-His)]
The lipid peptide type compound used in this example was synthesized by the following method.
A 500 mL four-necked flask was charged with 14.2 g (91.6 mmol) of histidine, 30.0 g (91.6 mmol) of N-palmitoyl-Gly-methyl and 300 g of toluene, and a sodium methoxide 28% methanol solution as a base. 35.3 g (183.2 mmol) was added, and the mixture was heated to 60 ° C. in an oil bath and stirred for 1 hour. Thereafter, the oil bath was removed and the mixture was allowed to cool to 25 ° C. This solution was reprecipitated with 600 g of acetone and collected by filtration. The solid obtained here was dissolved in a mixed solution of 600 g of water and 750 g of methanol, and 30.5 ml (183.2 mmol) of 6N hydrochloric acid was added thereto for neutralization to precipitate a solid, followed by filtration. Next, the obtained solid was dissolved in a mixed solution of 120 g of tetrahydrofuran and 30 g of water at 60 ° C., 150 g of ethyl acetate was added, and the mixture was cooled from 60 ° C. to 30 ° C. Thereafter, the precipitated solid was filtered. Further, the obtained solid was dissolved in 120 g of tetrahydrofuran and 60 g of acetonitrile, heated to 60 ° C., stirred for 1 hour, cooled, and filtered. The solid obtained here was washed with 120 g of water, dried under reduced pressure after filtration, and 26.9 g (yield 65) of white crystals of N-palmitoyl-Gly-His free form (hereinafter also simply referred to as “Pal-GH”). %).

[Example 1: Preparation of liquid foundation containing 10% by mass of pigment]
According to the following Table 1, a liquid foundation containing 10% by mass of pigment was prepared.
In a Laboran screw tube (No. 7, As One Co., Ltd.), 5.0 g of pigment and 33.0 g of pure water were stirred at 80 ° C. for 2 minutes and heated to 80 ° C. with 1,2-hexane. 1.0 g of diol was added and stirred for 2 minutes.
To this, 1.0 g of the composition [1] heated to 80 ° C. was added and stirred for 2 minutes, then 10.0 g of glycerin heated to 80 ° C. was added and stirred for 3 minutes, and the temperature reached room temperature. The solution was stirred and cooled to obtain a liquid foundation.
Composition [1] has the composition shown in Table 1 and is mixed with Pal-GH, polyoxyethylene lauryl ether, and purified water, heated and stirred at 70 ° C., and 1,2-hexanediol and stearic acid were added thereto. The mixture was further stirred at 70 ° C. and then allowed to cool to room temperature. Also in the following examples, the composition [1] obtained by the same procedure was used.
All stirring in the above manufacturing process was performed at 400 rpm.

[Example 2: Preparation of 10% by mass pigment white water powder foundation]
A white powder foundation containing 10% by mass of the pigment shown in Table 1 was produced in the same procedure as in Example 1 except that 0.5 g of the composition [1] and 33.5 g of pure water were used.

[Example 3: Preparation of a white powder foundation containing 15% by mass of pigment]
A white powder foundation containing 15% by mass of the pigment shown in Table 1 was produced in the same procedure as in Example 2 except that 7.5 g of the pigment and 31 g of pure water were used.

[Comparative Example 1]
A foundation of a comparative example in which 10% by mass of the pigment shown in Table 1 was blended was prepared in the same procedure as in Example 1 except that the composition [1] was not blended and the pure water was changed to 34.0 g.

FIG. 1 shows the foundations (appearance) of Examples 1 to 3 and Comparative Example 1.
As shown in FIG. 1, in Examples 1 to 3 in which the composition [1] containing Pal-GH was blended, the pigment was scattered and the dispersion stability of the pigment was confirmed. Further, by adjusting the blending amount of the composition [1] containing Pal-GH, a liquid foundation type with high viscosity (Example 1) and a white powder foundation type with low viscosity (Example 2 and Example) Example 3) could be prepared.
On the other hand, in Comparative Example 1 in which the composition [1] containing Pal-GH was not blended, as shown in FIG. 1, the pigment and other components were separated, resulting in precipitation of the pigment.

[Example 4: Preparation of dispersion liquid containing 2% by mass of pearl pigment]
According to Table 2 below, a dispersion containing 2% by mass of pearl pigment was prepared.
In a Labor screw screw bottle (No. 7, As One Co., Ltd.), 1.0 g of pearl pigment and 33.5 g of pure water were stirred at 80 ° C. for 2 minutes, and then heated to 80 ° C. 5.0 g of butylene glycol (1,3-butanediol) was added and mixed with stirring for 2 minutes.
To this, 0.5 g of composition [1] heated to 80 ° C. was added and mixed with stirring for 2 minutes, then 10.0 g of glycerin heated to 80 ° C. was added and mixed for 3 minutes, and the temperature reached room temperature. The solution was stirred and cooled to obtain a dispersion.
All stirring in the above manufacturing process was performed at 400 rpm.

[Example 5: Preparation of 0.5% by mass of pearl pigment dispersion]
According to the following Table 2, a dispersion liquid containing 0.5% by mass of a pearl pigment was prepared.
In a Labor screw screw bottle (No. 7, AS ONE Co., Ltd.), 0.25 g of pearl pigment and 49.25 g of pure water were stirred at 80 ° C. for 2 minutes and heated to 80 ° C. [1] After adding 0.5 g and stirring and mixing for 2 minutes, the mixture was stirred and cooled to room temperature as it was to obtain a dispersion.
All stirring in the above manufacturing process was performed at 400 rpm.

[Comparative Example 2]
A dispersion of a comparative example containing 2% by mass of the pearl pigment shown in Table 2 was prepared in the same procedure as in Example 4 except that the composition [1] was not blended and 34.0 g of pure water was used. did.

FIG. 2 shows pearl pigment-containing dispersions (appearance) of Examples 4 and 5 and Comparative Example 2.
As shown in FIG. 2, in Comparative Example 2 in which the composition [1] containing Pal-GH was not blended, the pearl pigment and other components were separated, resulting in precipitation of the pearl pigment. In Example 4 and Example 5 in which the composition [1] was blended, the dispersibility of the pearl pigment was improved.

[Example 6: Preparation of tricalcium phosphate dispersion]
According to Table 3 below, a dispersion containing 0.5% by mass of tricalcium phosphate was prepared.
A composition obtained by stirring 0.25 g of tricalcium phosphate and 49.25 g of pure water at 80 ° C. for 2 minutes in a Laborun screw tube bottle (No. 7, As One Co., Ltd.) and heating it to 80 ° C. [1] After adding 0.5 g and stirring and mixing for 2 minutes, the mixture was stirred and cooled to room temperature as it was to obtain a dispersion.
All stirring in the above manufacturing process was performed at 400 rpm.

[Comparative Example 3]
A comparative example in which 0.5% by mass of tricalcium phosphate shown in Table 3 was blended in the same procedure as in Example 5 except that the composition [1] was not blended and the pure water was 49.75 g. A dispersion was prepared.

FIG. 3 shows the tricalcium phosphate blend dispersion (appearance) of Example 6 and Comparative Example 3.
As shown in FIG. 3, in Comparative Example 3 in which the composition [1] containing Pal-GH was not blended, tricalcium phosphate and other components were separated, resulting in precipitation of tricalcium phosphate. However, in Example 6 containing the composition [1], the dispersibility of tricalcium phosphate was improved.

[Example 7: Production of 0.01% by mass of gold foil mixed dispersion]
According to Table 4 below, a dispersion liquid containing 0.01% by mass of gold foil (approximately 2 mm square to 10 mm square) was prepared.
A composition [1] 0 in which 5 mg of gold foil and 49.745 g of pure water were stirred at 80 ° C. for 2 minutes and heated to 80 ° C. in a Laboran screw tube (No. 7, As One Co., Ltd.) .25 g was added and stirred and mixed for 2 minutes, and then stirred and cooled to room temperature as it was to obtain a dispersion.
All stirring in the above manufacturing process was performed at 400 rpm.

[Example 8: Preparation of 0.05 mass% dispersion of gold foil]
A dispersion containing 0.05% by mass of the gold foil shown in Table 4 was prepared in the same manner as in Example 7 except that 25 mg of the gold foil, 0.5 g of the composition [1] and 49.475 g of pure water were used. Manufactured.

[Comparative Example 4]
A dispersion of a comparative example in which 0.01% by mass of the gold foil shown in Table 4 was blended in the same procedure as in Example 7 except that the composition [1] was not blended and the pure water was 49.95 g. Prepared.

FIG. 4 shows the gold foil-containing dispersion (appearance) of Examples 7 and 8 and Comparative Example 4.
As shown in FIG. 4, in Comparative Example 4 in which the composition [1] containing Pal-GH was not blended, the gold foil and other components were separated, and the gold foil floated or precipitated depending on its weight. However, in Examples 7 and 8 in which the composition [1] was blended, the dispersibility of tricalcium phosphate was improved.
At this time, it was possible to adjust the blending amount of the gold foil and the transparency of the dispersion by adjusting the blending amount of the composition [1] containing Pal-GH.

[Example 9: Preparation of 17% by mass of pigment and preparation of O / W liquid foundation]
According to Table 5 below, a foundation in which 17% by mass of pigment was uniformly dispersed was prepared.
In a 200 mL beaker (made by HARIO), 34.0 g of pigment (fresh color base aqua), 139.6 g of purified water, 0.2 g of sodium N-stearoylmethyl taurine (NIKKOL SMT, Nikko Chemicals), lecithin (LPA) , 0.2 g of Nikko Chemicals Co., Ltd., 0.2 g of EDTA-2Na (Pure Chemical Co., Ltd.), 0.4 g of hydroxypropylcellulose (NISSO SSL, Nippon Soda Co., Ltd.), xanthan gum (KELTROL-CG-ST, 0.4 g of Sanki Co., Ltd. was mixed and heated and stirred at 75 ° C. for 10 minutes (phase B).
In a 200 mL beaker (manufactured by HARIO Co., Ltd.), NIKKOL Nicomulus 41 (Nikko Chemicals Co., Ltd.) 4.0 g, NIKKOL NATURAL OILS (Nikko Chemicals Co., Ltd.) 14.0 g, NIKKOL Nicoguard 88 (Nikko Chemicals Co., Ltd.) 1 0.0 g was added and stirred with heating at 75 ° C. for 10 minutes (phase A).
Phase A was added to Phase B with slow stirring, and the resulting mixture was added at 75 ° C. for 3 minutes at 5,000 rpm using a homomixer (QUICK HOMO MIXER LR-1A, manufactured by Mizuho Industry Co., Ltd.). An emulsification treatment was performed. Further, 2.0 g of the composition [1] heated to 75 ° C. was added, and the mixture was heated and stirred at 75 ° C. for 2 minutes, and then stirred and cooled at room temperature until reaching 40 ° C. After confirming that the temperature reached 40 ° C., 4.0 g (phase C) of NIKKOL NET-813-1 (Nikko Chemicals Co., Ltd.) was added, and stirring and cooling were performed until the temperature reached 35 ° C.
In the above steps, all stirring was performed at 200 rpm.

[Comparative Example 5]
According to Table 5 below, a foundation containing 17% by mass of pigment was prepared.
In a 200 mL beaker (manufactured by HARIO), 34.0 g of pigment (fresh color base aqua), 141.6 g of purified water, 0.2 g of sodium N-stearoylmethyltaurine (NIKKOL SMT, Nikko Chemicals), lecithin (LPA) , 0.2 g of Nikko Chemicals Co., Ltd., 0.2 g of EDTA-2Na (Pure Chemical Co., Ltd.), 0.4 g of hydroxypropylcellulose (NISSO SSL, Nippon Soda Co., Ltd.), xanthan gum (KELTROL-CG-ST, 0.4 g of Sanki Co., Ltd. was mixed and heated and stirred at 75 ° C. for 10 minutes (phase B).
In a 200 mL beaker (manufactured by HARIO Co., Ltd.), NIKKOL Nicomulus 41 (Nikko Chemicals Co., Ltd.) 4.0 g, NIKKOL NATURAL OILS (Nikko Chemicals Co., Ltd.) 14.0 g, NIKKOL Nicoguard 88 (Nikko Chemicals Co., Ltd.) 1 0.0 g was added and stirred with heating at 75 ° C. for 10 minutes (phase A).
Phase A was added to Phase B with slow stirring, and the resulting mixture was added at 75 ° C. for 3 minutes at 5,000 rpm using a homomixer (QUICK HOMO MIXER LR-1A, manufactured by Mizuho Industry Co., Ltd.). An emulsification treatment was performed. Thereafter, stirring and cooling were performed at room temperature until reaching 40 ° C., 4.0 g (C phase) of NIKKOL NET-813-1 (Nikko Chemicals Co., Ltd.) was added, and stirring and cooling were performed until reaching 35 ° C.
In the above steps, all stirring was performed at 200 rpm.

FIG. 5 shows the results of pigment dispersibility evaluation by observation (photograph) of a polarizing microscope (manufactured by Olympus Corporation) of the O / W liquid foundation of Example 9 and Comparative Example 5. As shown in FIG. 5, in Comparative Example 5 in which the composition [1] containing Pal-GH was not blended, a lot of pigment aggregation was observed, resulting in non-uniform dispersibility. In Example 9 containing the composition [1], the dispersibility of the pigment was improved.

FIG. 6 shows the O / W liquid foundation (appearance) of Example 9 and Comparative Example 5 after the liquid foundation was prepared and stored for one month. As shown in FIG. 6, in Comparative Example 5 in which the composition [1] containing Pal-GH was not blended, separation of the pigment and oil was observed (in the figure, the separation state was uneven color). Observed), the dispersibility was non-uniform, but in Example 9 in which the composition [1] was blended, the dispersibility of the pigment was improved.

Claims (9)

A surfactant,
water and,
A pigment or powder dispersant comprising a lipid peptide type compound comprising at least one of the compounds represented by the following formulas (1) to (3) or a pharmaceutically usable salt thereof:
1,2-alkanediol or 1,3-alkanediol;
At least one fatty acid,
Including at least one selected from the group consisting of pigments and powders,
Dispersion.

(Wherein R ¹ represents an aliphatic group having 9 to 23 carbon atoms, R ² represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms) R ³ represents a — (CH ₂ ) n—X group, n represents a number of 1 to 4, X represents an amino group, a guanidino group, a —CONH ₂ group, or 1 to 3 nitrogen atoms. And represents a condensed heterocyclic ring composed of a 5-membered ring or a 6-membered ring or a 5-membered ring and a 6-membered ring.)

(Wherein R ⁴ represents an aliphatic group having 9 to 23 carbon atoms, and R ^{5 to} R ⁷ each independently represents a hydrogen atom, or a carbon atom number that can have a branched chain having 1 or 2 carbon atoms. 1 to 4 alkyl groups or — (CH ₂ ) n—X groups, and at least one of R ^{5 to} R ⁷ represents — (CH ₂ ) n—X groups, and n is 1 to 4 X represents an amino group, a guanidino group, a —CONH ₂ group, or a 5- or 6-membered ring having 1 to 3 nitrogen atoms, or a condensed heterocycle composed of a 5-membered ring and a 6-membered ring. Represents a ring.)

(In the formula, R ⁸ represents an aliphatic group having 9 to 23 carbon atoms, and R ^{9 to} R ¹² each independently represents a hydrogen atom, or the number of carbon atoms that may have a branched chain having 1 or 2 carbon atoms. 1 to 4 alkyl groups or — (CH ₂ ) n—X groups, and at least one of R ^{9 to} R ¹² represents — (CH ₂ ) n—X groups, and n is 1 to 4 X represents an amino group, a guanidino group, a —CONH ₂ group, or a 5- or 6-membered ring having 1 to 3 nitrogen atoms, or a condensed heterocycle composed of a 5-membered ring and a 6-membered ring. Represents a ring.) The dispersion according to claim 1, wherein at least one selected from the group consisting of the pigment and the powder is contained in a proportion of 25% by mass or less based on the total mass of the dispersion. The dispersion according to claim 1 or 2, wherein the pigment or powder dispersant is contained in a proportion of 0.01% by mass to 1% by mass based on the total mass of the dispersion. Furthermore, the dispersion liquid as described in any one of Claims 1 thru | or 3 containing a polyhydric alcohol. The dispersion according to claim 4, wherein the polyhydric alcohol is glycerin. 6. The surfactant according to claim 1, wherein the surfactant is one or more compounds selected from the group consisting of ethylene glycol alkyl ether, phospholipid, polyglycerin fatty acid ester and polyoxyethylene polyoxypropylene alkyl ether. The dispersion liquid as described in any one of them. The dispersion according to any one of claims 1 to 6, wherein the fatty acid is stearic acid. The dispersion according to any one of claims 1 to 7, which is a dispersion for cosmetics. A pigment or powder dispersant comprising a lipid peptide type compound comprising at least one of the compounds represented by the following formulas (1) to (3) or a pharmaceutically usable salt thereof.

(Wherein R ¹ represents an aliphatic group having 9 to 23 carbon atoms, R ² represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms) R ³ represents a — (CH ₂ ) n—X group, n represents a number of 1 to 4, X represents an amino group, a guanidino group, a —CONH ₂ group, or 1 to 3 nitrogen atoms. And represents a condensed heterocyclic ring composed of a 5-membered ring or a 6-membered ring or a 5-membered ring and a 6-membered ring.)

(Wherein R ⁴ represents an aliphatic group having 9 to 23 carbon atoms, and R ^{5 to} R ⁷ each independently represents a hydrogen atom, or a carbon atom number that can have a branched chain having 1 or 2 carbon atoms. 1 to 4 alkyl groups or — (CH ₂ ) n—X groups, and at least one of R ^{5 to} R ⁷ represents — (CH ₂ ) n—X groups, and n is 1 to 4 X represents an amino group, a guanidino group, a —CONH ₂ group, or a 5- or 6-membered ring having 1 to 3 nitrogen atoms, or a condensed heterocycle composed of a 5-membered ring and a 6-membered ring. Represents a ring.)

(In the formula, R ⁸ represents an aliphatic group having 9 to 23 carbon atoms, and R ^{9 to} R ¹² each independently represents a hydrogen atom, or the number of carbon atoms that may have a branched chain having 1 or 2 carbon atoms. 1 to 4 alkyl groups or — (CH ₂ ) n—X groups, and at least one of R ^{9 to} R ¹² represents — (CH ₂ ) n—X groups, and n is 1 to 4 X represents an amino group, a guanidino group, a —CONH ₂ group, or a 5- or 6-membered ring having 1 to 3 nitrogen atoms, or a condensed heterocycle composed of a 5-membered ring and a 6-membered ring. Represents a ring.)

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