WO2018207947A1 - Polysaccharide-containing stick-shaped base material - Google Patents

Abstract

[Problem] To provide a stick-shaped base material capable of having a desired break strength for a stick-shaped base material even if the lipid peptide compound amount is reduced. [Solution] A stick-shaped base material including: at least one type of surfactant selected from the group consisting of a betaine compound and ethylene glycol alkyl ether; water; a lipid peptide compound comprising at least one type selected from a compound indicted by formula (1) or a pharmaceutically useful salt thereof; at least one type of C8–3 saturated or unsaturated monohydric alcohol; and at least one type of thickener selected from the group consisting of an alginic acid derivative and carrageenan. (In the formula, R¹ indicates a C9–23 aliphatic group, R² indicates a hydrocarbon atom or a C1–4 alkyl group capable of having a C1–2 branched chain, R³ indicates a –(CH₂)_n–X group, n indicates a number 1–4, and X indicates a fused heterocycle comprising a 5-membered ring, a 6-membered ring, or a 5-membered ring and a 6-membered ring, and capable of having 1–3 amino groups, guanidino groups, –CONH₂ groups, or nitrogen atoms.)

Description

Polysaccharide-containing stick-like substrate

The present invention relates to a stick-shaped substrate containing a lipid peptide-type compound, and in particular, a stick-shaped substrate that can have a breaking strength required as a stick-shaped substrate even if the amount of the lipid peptide-type compound is reduced. Regarding materials.

The aqueous solid composition provides a high refreshing feeling when applied to the skin, etc., and has no stickiness after use as compared to the oily solid composition, so that it has a smooth use feeling. A variety of products are marketed and proposed.
As an aqueous solid composition, conventionally, a solid oil-in-water makeup cosmetic (Patent Document 1) containing water, fatty acid soap, oil and powder, an alkyl and / or alkenyl oligoglycoside, an oily substance, and a nonionic emulsifier A stick-like water-based cosmetic (Patent Document 2) and the like have been proposed.

Moreover, an aqueous gel composition is mentioned as a kind of aqueous solid composition. As an additive for obtaining this aqueous gel, various compounds such as a polymer gelling agent and a low molecular gelling agent have been proposed. For example, in recent years, lipid peptide type low molecular gelling agents that have high biological safety and are expected to be developed into medical materials have been proposed.

It has also been reported that a stick-like substrate having a high breaking strength can be obtained by using a lipid peptide type compound having a specific structure (Patent Document 3).

JP-A-3-279319 JP-T-2002-516818 International Publication No. 2015/099074 Pamphlet

The stick-shaped substrate described in Patent Document 3 uses about 5% by mass of the lipid peptide type compound based on the total mass of the stick-shaped substrate. However, the lipid peptide type compound is expensive, and therefore, A stick-like substrate capable of reducing the amount of lipid peptide type compound is desired.
Accordingly, an object of the present invention is to provide a stick-like substrate that can have the breaking strength required as a stick-like substrate even if the amount of the lipid peptide type compound is reduced.

As a result of intensive studies to solve the above problems, the present inventors have found that a lipid peptide type compound (gelator) comprising a low-molecular-weight lipid peptide or a pharmaceutically usable salt thereof and water as main constituent components In the stick-like base material, a specific surfactant and a specific thickening agent are blended to have the breaking strength required as a stick-like base material even if the amount of lipid peptide type compound is reduced. The present invention was completed.

（式中、Ｒ¹は炭素原子数９乃至２３の脂肪族基を表し、Ｒ²は水素原子、又は炭素原子数１若しくは２の分枝鎖を有し得る炭素原子数１乃至４のアルキル基を表し、Ｒ³は－（ＣＨ₂）_n－Ｘ基を表し、ｎは１乃至４の数を表し、Ｘはアミノ基、グアニジノ基、－ＣＯＮＨ₂基、又は窒素原子を１乃至３個有し得る５員環若しくは６員環又は５員環と６員環から構成される縮合複素環を表す。）

（式中、Ｒ⁴は炭素原子数９乃至２３の脂肪族基を表し、Ｒ⁵乃至Ｒ⁷はそれぞれ独立して水素原子、炭素原子数１若しくは２の分枝鎖を有し得る炭素原子数１乃至４のアルキル基、又は－（ＣＨ₂）_n－Ｘ基を表し、ｎは１乃至４の数を表し、Ｘはアミノ基、グアニジノ基、－ＣＯＮＨ₂基、又は窒素原子を１乃至３個有し得る５員環若しくは６員環又は５員環と６員環から構成される縮合複素環を表す。）

（式中、Ｒ⁸は炭素原子数９乃至２３の脂肪族基を表し、Ｒ⁹乃至Ｒ¹²はそれぞれ独立して水素原子、炭素原子数１若しくは２の分枝鎖を有し得る炭素原子数１乃至４のアルキル基、又は－（ＣＨ₂）_n－Ｘ基を表し、ｎは１乃至４の数を表し、Ｘはアミノ基、グアニジノ基、－ＣＯＮＨ₂基、又は窒素原子を１乃至３個有し得る５員環若しくは６員環又は５員環と６員環から構成される縮合複素環を表す。）
第２観点として、前記界面活性剤が、エチレングリコールアルキルエーテルである、第１観点に記載のスティック状基材に関する。
第３観点として、更に、１，２－アルカンジオール又は１，３－アルカンジオールを含む、第１観点に記載のスティック状基材に関する。
　第４観点として、前記アルギン酸誘導体が、アルギン酸多価アルコールエステルである、第３観点に記載のスティック状基材に関する。
　第５観点として、前記増粘剤が、スティック状基材の総質量に基いて０．１～１．０質量％の割合にて含まれてなる、第１観点乃至第４観点のうち何れか一つに記載のスティック状基材に関する。
　第６観点として、前記ベタイン系化合物が、硫酸型ベタインである、第３観点乃至第５観点のうち何れか一つに記載のスティック状基材に関する。
　第７観点として、前記一価アルコールが、ミリスチルアルコール、セタノール、ステアリルアルコール及びベヘニルアルコールからなる群から選択される１種以上の化合物である、第１観点乃至第６観点のうち何れか一つに記載のスティック状基材に関する。
　第８観点として、前記脂質ペプチド型化合物が、スティック状基材の総質量に基いて０．１～２質量％の割合にて含まれてなる、第１観点乃至第７観点のうち何れか一つに記載のスティック状基材に関する。 That is, the present invention provides the first aspect as follows:
One or more surfactants selected from the group consisting of betaine compounds and ethylene glycol alkyl ethers;
water and,
A lipid peptide type compound comprising at least one of the compounds represented by the following formulas (1) to (3) or a pharmaceutically usable salt thereof;
At least one saturated or unsaturated monohydric alcohol having 8 to 30 carbon atoms;
One or more thickeners selected from the group consisting of alginic acid derivatives and carrageenan,
The present invention relates to a stick-like substrate.

(In the formula, R ¹ represents an aliphatic group having 9 to 23 carbon atoms, and R ² represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms. R ³ represents a — (CH ₂ ) _n —X group, n represents a number of 1 to 4, X represents an amino group, a guanidino group, a —CONH ₂ group, or 1 to 3 nitrogen atoms. And represents a condensed heterocyclic ring composed of a 5-membered ring or a 6-membered ring or a 5-membered ring and a 6-membered ring.)

(Wherein R ⁴ represents an aliphatic group having 9 to 23 carbon atoms, and R ^{5 to} R ⁷ each independently represents a hydrogen atom or a carbon atom having a branched chain having 1 or 2 carbon atoms. 1 to 4 alkyl groups or — (CH ₂ ) _n —X group, n represents a number of 1 to 4, and X represents an amino group, a guanidino group, a —CONH ₂ group, or a nitrogen atom of 1 to 3 This represents a 5-membered ring or 6-membered ring which may have one or a condensed heterocyclic ring composed of a 5-membered ring and a 6-membered ring.)

(In the formula, R ⁸ represents an aliphatic group having 9 to 23 carbon atoms, and R ^{9 to} R ¹² each independently represents a hydrogen atom, or a carbon atom number that can have a branched chain having 1 or 2 carbon atoms. 1 to 4 alkyl, or - (CH _{2) n} represents an -X group, n represents a number from 1 to 4, X is an amino group, a guanidino group, -CONH ₂ group, or a nitrogen atom and 1 to 3 This represents a 5-membered ring or 6-membered ring which may have one or a condensed heterocyclic ring composed of a 5-membered ring and a 6-membered ring.)
As a second aspect, the present invention relates to the stick-shaped substrate according to the first aspect, in which the surfactant is ethylene glycol alkyl ether.
As a third aspect, the present invention further relates to the stick-like substrate according to the first aspect, further comprising 1,2-alkanediol or 1,3-alkanediol.
As a fourth aspect, the present invention relates to the stick-shaped substrate according to the third aspect, in which the alginic acid derivative is an alginate polyhydric alcohol ester.
As a fifth aspect, any one of the first aspect to the fourth aspect, wherein the thickener is included in a proportion of 0.1 to 1.0% by mass based on the total mass of the stick-like substrate. The present invention relates to the stick-like substrate described in one.
As a sixth aspect, the present invention relates to the stick-like substrate according to any one of the third to fifth aspects, wherein the betaine compound is sulfate-type betaine.
As a seventh aspect, the monohydric alcohol is one or more compounds selected from the group consisting of myristyl alcohol, cetanol, stearyl alcohol, and behenyl alcohol, according to any one of the first to sixth aspects. This relates to a stick-like substrate.
As an eighth aspect, any one of the first aspect to the seventh aspect, wherein the lipid peptide type compound is contained at a ratio of 0.1 to 2% by mass based on the total mass of the stick-like substrate. It relates to the stick-like base material described in one.

ADVANTAGE OF THE INVENTION According to this invention, even if it reduces the quantity of a lipid peptide type compound, the stick-shaped base material which can have the breaking strength calculated | required as a stick-shaped base material can be provided.
In particular, in the stick-shaped substrate of the present invention, the use of a specific surfactant and a specific thickener reduces the amount of lipid peptide type compound based on the total mass of the substrate. Even when the content is less than or equal to mass%, it may have a breaking strength required for a stick-like substrate.

Moreover, the lipid peptide compound contained in the stick-like substrate of the present invention is a very safe artificial low molecular weight compound composed only of lipid and peptide. In addition, the compound can form an aqueous gel without using a crosslinking agent or the like required for forming a synthetic polymer type gel that has been proposed in the past. The problem of remaining unreacted materials such as cross-linking agents does not occur.
Furthermore, various components contained as additives in the stick-shaped substrate of the present invention are general-purpose additives as additives for foods, cosmetics, and pharmaceuticals.

That is, the stick-shaped substrate of the present invention has high biological safety, and is particularly useful in the above applications from the viewpoint of safety required for pharmaceuticals and cosmetics.
In addition, the stick-like base material of the present invention is expected to be a base material having a good refreshing feeling when applied to human skin, etc. It is very useful as a stick-like base material for cosmetics and cosmetics.

The present invention relates to one or more surfactants selected from the group consisting of betaine compounds and ethylene glycol alkyl ethers, water, compounds represented by the following formulas (1) to (3), or pharmaceuticals thereof. A lipid peptide-type compound comprising at least one of the salts that can be used in the above, 1,2-alkanediol or 1,3-alkanediol, and at least one saturated or unsaturated monovalent group having 8 to 30 carbon atoms. The present invention relates to a stick-like substrate comprising alcohol, one or more thickeners selected from the group consisting of alginic acid derivatives and carrageenan, and optionally other additives.
Hereinafter, each component will be described.

[Lipid peptide type compound]
The lipid peptide type compound used in the stick-shaped substrate of the present invention is a compound (lipid peptide) represented by the following formulas (1) to (3) or a pharmaceutically usable salt thereof (hydrophobic site). A low molecular compound having a lipid part and a peptide part which is a hydrophilic part) can be used.

In the above formula (1), R ¹ represents an aliphatic group having 9 to 23 carbon atoms, and preferably R ¹ is a straight chain having 11 to 23 carbon atoms which may have 0 to 2 unsaturated bonds. An aliphatic group is desirable.
Specific examples of the lipid moiety (acyl group) composed of a carbonyl group adjacent to R ¹ include lauroyl group, dodecylcarbonyl group, myristoyl group, tetradecylcarbonyl group, palmitoyl group, margaroyl group, oleoyl group, and elideoyl group. Linoleoyl group, stearoyl group, baccenoyl group, octadecylcarbonyl group, arachidyl group, eicosylcarbonyl group, behenoyl group, ercanoyl group, docosylcarbonyl group, lignoceyl group, nerbonoyl group, etc. Examples include lauroyl group, myristoyl group, palmitoyl group, margaroyl group, stearoyl group, oleoyl group, elidoyl group, and behenoyl group.

In the above formula (1), R ² contained in the peptide part represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms.
The alkyl group having 1 to 4 carbon atoms that may have a branched chain having 1 or 2 carbon atoms is a branched chain having 1 to 4 carbon atoms in the main chain and 1 or 2 carbon atoms. Means an alkyl group which may have, and specific examples thereof include methyl group, ethyl group, n-propyl group, i-propyl group, n-butyl group, i-butyl group, sec-butyl group or tert-butyl group Etc.
R ² is preferably a hydrogen atom or an alkyl group having 1 to 3 carbon atoms which may have a branched chain having 1 carbon atom, and more preferably a hydrogen atom.
The alkyl group having 1 to 3 carbon atoms which can have a branched chain having 1 carbon atom is an alkyl group having 1 to 3 carbon atoms in the main chain and having a branched chain having 1 carbon atom. Specific examples thereof include a methyl group, an ethyl group, an n-propyl group, an i-propyl group, an i-butyl group, or a sec-butyl group, preferably a methyl group, an i-propyl group, An i-butyl group or a sec-butyl group.

In the above formula (1), R ³ represents a — (CH ₂ ) n—X group. In the — (CH ₂ ) n—X group, n represents a number of 1 to 4, and X is an amino group, a guanidino group, a —CONH ₂ group, or a 5-membered cyclic group having 1 to 3 nitrogen atoms. Represents a group, a 6-membered cyclic group, or a condensed heterocyclic group composed of a 5-membered ring and a 6-membered ring.
In the — (CH ₂ ) n—X group representing R ³ , X is preferably an amino group, guanidino group, carbamoyl group (—CONH ₂ group), pyrrole group, imidazole group, pyrazole group or indole group, and more Preferably it is an imidazole group. Also, the - in (CH ₂₎ n-X group, n is preferably 1 or 2, more preferably 1.
Therefore, the — (CH ₂ ) n- group is preferably an aminomethyl group, 2-aminoethyl group, 3-aminopropyl group, 4-aminobutyl group, carbamoylmethyl group, 2-carbamoylethyl group, 3-carbamoyl group. Represents a butyl group, a 2-guanidinoethyl group, a 3-guanidinobutyl group, a pyrrolemethyl group, a 4-imidazolemethyl group, a pyrazolemethyl group, or a 3-indolemethyl group, more preferably a 4-aminobutyl group, a carbamoylmethyl group Represents a 2-carbamoylethyl group, a 3-guanidinobutyl group, a 4-imidazolemethyl group or a 3-indolemethyl group, more preferably a 4-imidazolemethyl group.

In the compound represented by the above formula (1), a lipid peptide particularly suitable as a lipid peptide type compound is a compound formed from the following lipid part and peptide part (amino acid assembly part). As abbreviations for amino acids, alanine (Ala), asparagine (Asn), glutamine (Gln), glycine (Gly), histidine (His), isorosine (Ile), leucine (Leu), lysine (Lys), tryptophan (Trp) ), Valine (Val). Lauroyl-Gly-His, Lauroyl-Gly-Gln, Lauroyl-Gly-Asn, Lauroyl-Gly-Trp, Lauroyl-Gly-Lys, Lauroyl-Ala-His, Lauroyl-Ala-Gln, Lauroyl-Ala-Asn, Lauroyl -Ala-Trp, Lauroyl-Ala-Lys; Myristoyl-Gly-His, Myristoyl-Gly-Gln, Myristoyl-Gly-Asn, Myristoyl-Gly-Trp, Myristoyl-Gly-Lys, Myristoyl-Ala-His, Myristoyl-Ala -Gln, Myristoyl-Ala-Asn, Myristoyl-Ala-Trp, Myristoyl-Ala-Lys; Palmitoyl-Gly-His, Palmitoyl-Gly-Gln, Palmitoyl-Gly-A n, Palmitoyl-Gly-Trp, Palmitoyl-Gly-Lys, Palmitoyl-Ala-His, Palmitoyl-Ala-Gln, Palmitoyl-Ala-Asn, Palmitoyl-Ala-Trp, Palmitoyl-Ala-Lys; Stearoyl-Gly-His Stearoyl-Gly-Gln, stearoyl-Gly-Asn, stearoyl-Gly-Trp, stearoyl-Gly-Lys, stearoyl-Ala-His, stearoyl-Ala-Gln, stearoyl-Ala-Asn, stearoyl-Ala-Trp, stearoyl- Ala-Lys.

Most preferred are lauroyl-Gly-His, lauroyl-Ala-His-myristoyl-Gly-His, myristoyl-Ala-His; palmitoyl-Gly-His, palmitoyl-Ala-His; stearoyl-Gly-His, stearoyl-Ala -His.

In the above formula (2), R ⁴ represents an aliphatic group having 9 to 23 carbon atoms, and preferred specific examples include the same groups as defined for R ¹ above.
In the above formula (2), R ^{5 to} R ⁷ are each independently a hydrogen atom, an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms, or — ( CH ₂ ) nX group, and preferably at least one of R ^{5 to} R ⁷ represents a — (CH ₂ ) nX group. n represents a number of 1 to 4, and X represents an amino group, a guanidino group, a —CONH ₂ group, or a 5-membered cyclic group or a 6-membered cyclic group that may have 1 to 3 nitrogen atoms, or a 5-membered ring And a condensed heterocyclic group composed of a 6-membered ring. Here, preferred specific examples of R ^{5 to} R ⁷ include the same groups as defined for R ² and R ³ above.

In the compound represented by the above formula (2), a preferable lipid peptide is a compound formed from the following lipid part and peptide part (amino acid assembly part). For example,
Lauroyl-Gly-Gly-His, Lauroyl-Gly-Gly-Gln, Lauroyl-Gly-Gly-Asn, Lauroyl-Gly-Gly-Trp, Lauroyl-Gly-Gly-Lys, Lauroyl-Gly-Ala-His, Lauroyl-His Gly-Ala-Gln, Lauroyl-Gly-Ala-Asn, Lauroyl-Gly-Ala-Trp, Lauroyl-Gly-Ala-Lys, Lauroyl-Ala-Gly-His, Lauroyl-Ala-Gly-Gln, Lauroyl-Ala- Gly-Asn, Lauroyl-Ala-Gly-Trp, Lauroyl-Ala-Gly-Lys, Lauroyl-Gly-His-Gly, Lauroyl-His-Gly-Gly, Myristoyl-Gly-Gly-His, Myristoyl-G y-Gly-Gln, Myristoyl-Gly-Gly-Asn, Myristoyl-Gly-Gly-Trp, Myristoyl-Gly-Gly-Lys, Myristoyl-Gly-Ala-His, Myristoyl-Gly-Ala-Gln, Myristoyl-Gly- Ala-Asn, Myristoyl-Gly-Ala-Trp, Myristoyl-Gly-Ala-Lys, Myristoyl-Ala-Gly-His, Myristoyl-Ala-Gly-Gln, Myristoyl-Ala-Gly-Asn, Myristoyl-Ala-Gly- Trp, Myristoyl-Ala-Gly-Lys, Myristoyl-Gly-His-Gly, Myristoyl-His-Gly-Gly, Palmitoyl-Gly-Gly-His, Palmitoyl-Gly-Gly-Gln Palmitoyl-Gly-Gly-Asn, Palmitoyl-Gly-Gly-Trp, Palmitoyl-Gly-Gly-Lys, Palmitoyl-Gly-Ala-His, Palmitoyl-Gly-Ala-Gln, Palmitoyl-Gly-Ala-Asyl Gly-Ala-Trp, Palmitoyl-Gly-Ala-Lys, Palmitoyl-Ala-Gly-His, Palmitoyl-Ala-Gly-Gln, Palmitoyl-Ala-Gly-Asn, Palmitoyl-Ala-Gly-Trp, Palmitoyl-Ala- Gly-Lys, Palmitoyl-Gly-His-Gly, Palmitoyl-His-Gly-Gly, Stearoyl-Gly-Gly-His, Stearoyl-Gly-Gly-Gln, Stearoyl-Gly -Gly-Asn, stearoyl-Gly-Gly-Trp, stearoyl-Gly-Gly-Lys, stearoyl-Gly-Ala-His, stearoyl-Gly-Ala-Gln, stearoyl-Gly-Ala-Asn, stearoyl-Gly-Ala -Trp, stearoyl-Gly-Ala-Lys, stearoyl-Ala-Gly-His, stearoyl-Ala-Gly-Gln, stearoyl-Ala-Gly-Asn, stearoyl-Ala-Gly-Trp, stearoyl-Ala-Gly-Lys Stearoyl-Gly-His-Gly, stearoyl-His-Gly-Gly.

Of these, lauroyl-Gly-Gly-His, myristoyl-Gly-Gly-His, palmitoyl-Gly-Gly-His, palmitoyl-Gly-His-Gly, palmitoyl-His-Gly-Gly, stearoyl -Gly-Gly-His.

In the above formula (3), R ⁸ represents an aliphatic group having 9 to 23 carbon atoms, and preferred specific examples include the same groups as defined for R ¹ above.
In the above formula (3), R ^{9 to} R ¹² are each independently a hydrogen atom, an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms, or — ( CH ₂ ) nX group, and preferably at least one of R ^{9 to} R ¹² represents a — (CH ₂ ) nX group. n represents a number of 1 to 4, and X represents an amino group, a guanidino group, a —CONH ₂ group, or a 5-membered cyclic group or a 6-membered cyclic group that may have 1 to 3 nitrogen atoms, or a 5-membered ring And a condensed heterocyclic group composed of a 6-membered ring. Here, preferred specific examples of R ^{9 to} R ¹² include the same groups as defined for R ² and R ³ above.

Therefore, in the compound represented by the above formula (3), as preferred lipid peptide type compounds, particularly preferred lipid peptides include lauroyl-Gly-Gly-Gly-His, myristoyl-Gly-Gly-Gly-His, palmitoyl. -Gly-Gly-Gly-His, Palmitoyl-Gly-Gly-His-Gly, Palmitoyl-Gly-His-Gly-Gly, Palmitoyl-His-Gly-Gly-Gly, Stearoyl-Gly-Gly-Gly-His, etc. Can be mentioned.

In the present invention, the amount of the lipid peptide type compound is, for example, 0.1 to 2% by mass, preferably 0.3 to 1.5% by mass, and more preferably based on the total mass of the stick-like substrate to be obtained. Is 0.5 to 1.0 mass%.
The lipid peptide type compound used in the present invention comprises at least one of the compounds represented by the above formulas (1) to (3) (lipid peptide) or a pharmaceutically usable salt thereof, and is hydrogelated. These compounds can be used alone or in combination of two or more as an agent.

[Surfactant]
The surfactant used in the stick-shaped substrate of the present invention includes a compound having a hydrophilic part and a hydrophobic part in the molecule, and the hydrophilic part having a betaine structure (hereinafter also referred to as a betaine compound) and ethylene glycol. An alkyl ether is mentioned.

Examples of the betaine compounds as described above include N-alkyl-N, N-dimethylamino acid betaines such as lauryldimethylaminoacetic acid betaine (lauryl betaine); fatty acid amide alkyl-N such as cocamidopropyl betaine and lauramidopropyl betaine. N-dimethylamino acid betaine; imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkylsulfobetaines such as laurylhydroxysulfobetaine and alkyldimethyltaurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate; alkyldimethylaminoethanol Known betaine compounds such as phosphate-type betaines such as phosphate esters can be used as amphoteric surfactants.
As the betaine compound, sulfate-type betaine is preferable.
Examples of the betaine compounds include phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, phosphatidylglycerol, diphosphatidylglycerol (cardiolipin), phosphatidic acid and other glycerophospholipids; lysophosphatidylcholine (lysolecithin), lysophosphatidylethanolamine, Examples thereof include lysoglycerophospholipids such as serine, lysophosphatidylinositol, lysophosphatidylglycerol, and lysophosphatidic acid; sphingophospholipids such as sphingomyelin; and hydrogenated products thereof. These phospholipids may be derived from animals and plants such as soybeans and egg yolks, or may be synthesized by a chemical or enzymatic method.
Among the betaine compounds, preferably lauryldimethylaminoacetic acid betaine, lauric acid amidopropyl betaine, lauryl hydroxysulfobetaine, stearyl betaine, lysophosphatidylcholine (lysolecithin), lysophosphatidylethanolamine, lysophosphatidylserine, lysophosphatidylinositol, lyso Examples include phosphatidylglycerol and lysophosphatidic acid, and more preferably lauryl hydroxysulfobetaine.

Examples of the ethylene glycol alkyl ether include polyoxyethylene alkyl ether, polyoxyethylene lauryl ether, polyoxyethylene palmitoyl ether, and polyoxyethylene stearyl ether. Polyoxyethylene lauryl ether is preferable.
Also, commercially available ethylene glycol alkyl ethers can be used. Examples of such products include Emulgen 102KG, Emargen 103, and Emulgen 104P in Kao's Emulgen (registered trademark) series and Emanon (registered trademark) series. Emulgen 105, Emulgen 106, Emulgen 108, Emulgen 109P, Emulgen 120P, Emulgen 123P, Emulgen 130K, Emulgen 147, Emulgen 150, Emulgen 210P, Emulgen 220, Emulgen 306P, Emulgen 320P, Emulgen 350, Emulgen 404, Emulgen 408, Emulgen 409PV, Emulgen 420, Emulgen 430, Emulgen 705, Emulgen 707, Emulgen 709, Emulgen 1108, Emulgen 1118S-70, Emulgen 1135S-70, Emulgen 1150S-60, Emulgen 4085, Emulgen 2020G-HA, Emulgen 2025G, Emanon 1112, Emanor 3199V, Emanon 3299V, Emanon 3299RV, include the Emanon 4110. More preferably, Kao's Emulgen 103, Emulgen 104P, Emulgen 105, Emulgen 106, Emulgen 108, Emulgen 109P, Emulgen 210P, Emulgen 306P, Emulgen 320P, Emulgen 404, Emulgen 408, Emulgen 409PV, Emulgen 420, Emulgen 705 , Emulgen 707, Emulgen 709, Emulgen 1108, Emulgen 2020G-HA, Emanon 1112, Emanon 4110. More preferably, Kao's Emulgen 104P, Emulgen 105, Emulgen 106, Emulgen 108, Emulgen 210P, Emulgen 306P, Emulgen 408, Emulgen 409PV, Emulgen 705, Emulgen 707, Emulgen 709, Emulgen 1108, Emulgen 2020G-HA, Emanon 1112, Emanon 4110. In addition to this, it can be appropriately selected from the NIKKOL (registered trademark) series of Nikko Chemicals. For example, NIKKOL BT-5, NIKKOL BT-7, NIKKOL BT-9, NIKKOL BT-12, NIKKOL BL-2, NIKKOL BL-4.2, NIKKOL BL-9EX, etc., most preferably NIKOL BL-9EX 9EX.

In addition, as the surfactant used in the present invention, those having an HLB (Hydrophile-Lipophile Balance) value of 8 to 20 can be suitably used. More preferably, the HLB value is 8 to 14.

In the present invention, the compounding amount of the surfactant is, for example, 0.1 to 20% by mass, preferably 0.1 to 10% by mass with respect to the total mass of the stick-like substrate to be obtained.
In addition, when ethylene glycol alkyl ether is used as the surfactant, for example, 0.1 to 3% by mass is preferable with respect to the total mass of the obtained stick-like substrate, and when a betaine compound is used, it is obtained. For example, 0.5 to 10% by mass is preferable with respect to the total mass of the stick-shaped substrate.
The surfactant used in the present invention is at least one of the above-mentioned surfactant group, and these surfactants can be used alone or in combination of two or more.

[1,2-alkanediol or 1,3-alkanediol]
The 1,2-alkanediol or 1,3-alkanediol used in the stick-like substrate of the present invention has a function of promoting the solubility of the lipid peptide type compound.
1,3-alkanediol is preferred.
Specific examples of the 1,2-alkanediol include 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol, and the like. Preferred are 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol. More preferred is 1,2-pentanediol or 1,2-hexanediol. The 1,2-alkanediol used in the present invention is at least one of the aforementioned 1,2-alkanediol group.
Specific examples of the 1,3-alkanediol include 1,3-propanediol, 2-methyl-1,3-propanediol, 1,3-butanediol, 3-methyl-1,3-butanediol, , 3-pentanediol, 1,3-hexanediol, 2-ethyl-1,3-hexanediol, 2-ethyl-1,3-octanediol, 1,3-decanediol, and the like. Preferred are 1,3-pentanediol, 1,3-hexanediol, 2-ethyl-1,3-hexanediol, and 2-ethyl-1,3-octanediol. More preferred are 2-ethyl-1,3-hexanediol and 2-ethyl-1,3-octanediol. The 1,3-alkanediol used in the present invention is at least one of the aforementioned 1,3-alkanediol group.
As the 1,3-alkanediol, for example, 1,3-butanediol is preferable.
These 1,2-alkanediols or 1,3-alkanediols can be used alone or in combination of two or more.

In the present invention, the blending amount of 1,2-alkanediol or 1,3-alkanediol is, for example, 0.5 to 20% by mass, preferably 1 to 1% by mass with respect to the total mass of the obtained stick-like substrate. It is 10% by mass, more preferably 2 to 8% by mass.

[At least one saturated or unsaturated monohydric alcohol having 8 to 30 carbon atoms]
By adding at least one saturated or unsaturated monohydric alcohol having 8 to 30 carbon atoms to the stick-shaped substrate of the present invention, the stability of the substrate is improved, specifically the surface of the substrate. The oil release phenomenon called “sweat” can be suppressed. In the present specification, at least one saturated or unsaturated monohydric alcohol having 8 to 30 carbon atoms is also simply referred to as “higher alcohol”.
These higher alcohols are commercially available or synthesized many raw materials including derivatives, but in the stick-like base material of the present invention, preferably at least one kind of alkyl group having 8 to 30 carbon atoms. Saturated or unsaturated monohydric alcohols can be used, more preferably 12 to 22 saturated monohydric alcohols, among which myristyl alcohol (14 carbon atoms), cetanol (16 carbon atoms). Stearyl alcohol (18 carbon atoms) and behenyl alcohol (22 carbon atoms) are particularly preferred because of their high versatility and high “sweat” -suppressing effect.
In the present invention, the compounding amount of the higher alcohol is, for example, 0.001 to 1% by mass, preferably 0.01 to 0.5% by mass, and more preferably 0% with respect to the total mass of the stick-like substrate to be obtained. 0.03 to 0.3% by mass.
In addition, the said higher alcohol used in this invention is at least 1 type of the above-mentioned higher alcohol group, These can be used individually by 1 type or in combination of 2 or more types.

[Thickener]
Examples of the thickener used in the stick-shaped substrate of the present invention include alginic acid derivatives and carrageenan.
Examples of the alginic acid derivative used in the stick-shaped substrate of the present invention include alginic acid, alginic acid salts (sodium salt, potassium salt, calcium salt, etc.), alginic acid ester, and the like. Alcohol esters are preferred.
Examples of the alginic acid polyhydric alcohol ester include ethylene glycol alginate and propylene glycol alginate, and propylene glycol alginate is preferable.
In the present invention, the blending amount of the thickener used is, for example, 0.3 to 1.0% by mass, preferably 0.3 to 0.7% by mass, based on the total mass of the stick-like substrate to be obtained. It is.
In addition, the thickener used in this invention is at least 1 sort (s) of the thickener selected from the above, These thickeners can be used individually by 1 type or in combination of 2 or more types.

In addition to the above components and water, the stick-like substrate of the present invention can also contain fatty acids, oily bases, pigments, organic acids, polyhydric alcohols, and other additives.
Each component will be described below.

[fatty acid]
The fatty acid that can be used in the stick-shaped substrate of the present invention is preferably at least one selected from the group consisting of saturated fatty acids having 10 to 20 carbon atoms and unsaturated fatty acids and salts of these fatty acids. Examples include capric acid, undecanoic acid, lauric acid, tridecanoic acid, myristic acid, pentadecanoic acid, palmitic acid, margaric acid, and stearic acid. More preferably, capric acid, lauric acid, myristic acid, palmitic acid, and stearic acid are mentioned, and stearic acid is particularly preferable.
In the present invention, the amount of the fatty acid used is, for example, 0.1 to 2.0% by mass, preferably 0.2 to 1.0% by mass, based on the total mass of the stick-like substrate to be obtained. is there.
In addition, the fatty acid which can be used in this invention is at least 1 sort (s) selected from the said fatty acid group, These fatty acids can be used individually by 1 type or in combination of 2 or more types.

[Oil base]
The oily base that can be used in the stick-like substrate of the present invention is not particularly limited, and examples thereof include the following oily bases: oleyl alcohol, jojoba alcohol, chimyl alcohol, seraalkyl alcohol, batyl alcohol, Higher (polyhydric) alcohols such as hexyldecanol, isostearyl alcohol, 2-octyldodecanol, dimer diol; aralkyl alcohols such as benzyl alcohol and derivatives thereof; isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, palmi Tooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexadecanoic acid, antiisohenicosanoic acid, long-chain branched fatty acid, dimer acid, hydrogenated dimer acid, etc .; Hydrocarbons such as animal paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, solid paraffin; candelilla wax , Carnauba wax, rice wax, wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, Fischer-Tropsch wax, polyethylene wax, ethylene / propylene copolymer, etc .; palm oil, palm oil , Palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazel Nut oil, cucumber oil, rosehip oil, meadow foam oil, persic oil, tea tree oil, mint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, Vegetable oils such as cacao butter, shea butter, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil, grape seed oil, apricot oil (apricot oil), camellia oil; beef fat, milk fat, horse fat, Animal fats and oils such as egg yolk oil, mink oil and turtle oil; animal waxes such as whale wax, lanolin and orange luffy oil; liquid lanolin, reduced lanolin, adsorbed purified lanolin, lanolin acetate, lanolin acetate, hydroxy lanolin , Polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin acetate And lanolins such as acetic acid (cetyl lanolyl) ester; sterols such as cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol, cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonate, cholesteryl stearate, Cholesteryl isostearate, cholesteryl oleate, N-lauroyl-L-glutamate di (cholesteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di (cholesteryl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl) / Behenyl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / octyldodecyl), N-lauroyl sarcosine isopropyl, etc. Acyl sarcosine alkyl ester, cholesteryl 12-hydroxystearate, macadamia nut oil fatty acid cholesteryl, macadamia nut oil fatty acid phytosteryl, phytosteryl isostearate, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long chain branched fatty acid cholesteryl, long chain α-hydroxy fatty acid cholesteryl, etc. Sterol esters of phospholipid / cholesterol complex, phospholipid / phytosterol complex, etc .; octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl palmitate, octyldodecyl palmitate, octanoic acid Cetyl, hexyldecyl octoate, isotridecyl isononanoate, isononyl isononanoate, isononona Octyl acid, isotridecyl isononanoate, isodecyl neopentanoate, isotridecyl neopentanoate, isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, lanolin fatty acid octyldodecyl, hexyldecyl dimethyloctanoate, Octyldodecyl erucate, isostearic acid hydrogenated castor oil, ethyl oleate, avocado oil fatty acid ethyl, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, lanolin fatty acid isopropyl, diethyl sebacate, diisopropyl sebacate, sebacic acid Dioctyl, diisopropyl adipate, dibutyloctyl sebacate, adipic acid Monoalcohol carboxylates such as isobutyl, dioctyl succinate, triethyl citrate; oxyesters such as cetyl lactate, diisostearyl malate, hydrogenated castor oil monoisostearate; glyceryl trioctanoate (tri-2-ethylhexane) Glyceryl acid), glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, glyceryl tri (caprylic acid / capric acid), tri (caprylic acid / capric acid / myristic acid / stearic acid) glyceryl, hydrogenated rosin triglyceride (hydrogen Ester gum added), rosin triglyceride (ester gum), glyceryl behenate, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, dioctanoic acid Opentyl glycol, neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, ditritrihexanoate Methylolpropane, (isostearic acid / sebacic acid) ditrimethylolpropane, pentaerythrityl triethylhexanoate, (hydroxystearic acid / stearic acid / rosinic acid) dipentaerythrityl, diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl nonaisostearate-10 , Deca (erucic acid / isostearic acid / ricinoleic acid) polyglyceryl-8, (hexyldecanoic acid / sebacic acid) diglyceryl Polyhydric alcohol fatty acid esters such as ligoester, glycol distearate (ethylene glycol distearate), dineopentanoic acid 3-methyl-1,5-pentanediol, dineopentanoic acid 2,4-diethyl-1,5-pentanediol; Diisopropyl linoleate, diisostearyl dimerinolinoleate, dimerinolinoleate di (isostearyl / phytosteryl), dimerlinoleic acid (phytosteryl / behenyl), dimerlinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl) , Dimer dilinoleic acid dimer dilinoleyl, diisostearic acid dimer dilinoleyl, dimer dilinoleyl hydrogenated rosin condensate, dimer dilinoleic acid hydrogenated castor oil, hydroxyalkyl Dimer acid or dimer diol derivative such as imazyl linoleyl ether; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide ( Fatty acid alkanolamides such as lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), coconut oil fatty acid methylethanolamide (cocamidomethyl MEA); Dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, deca Methylcyclopentasiloxane (also simply cyclopentasiloxane), phenyltrimethicone, diphenyldimethicone, phenyldimethicone, stearoxypropyldimethylamine, (aminoethylaminopropylmethicone / dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone Amino-modified silicone such as rubber, aminopropyl dimethicone and amodimethicone, polyether-modified silicone such as cation-modified silicone and dimethicone copolyol, polyglycerin-modified silicone, sugar-modified silicone, carboxylic acid-modified silicone, phosphoric acid-modified silicone, sulfuric acid-modified silicone , Alkyl modified silicone, fatty acid modified silicone, alkyl ether modified silicone, amino acid modified silicone , Silicones such as peptide-modified silicone, fluorine-modified silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone, alkyl-modified and polyether-modified silicone, polysiloxane-oxyalkylene copolymer; perfluorodecane, Fluorine-based oils such as perfluorooctane and perfluoropolyether are preferred.

In the present invention, the blending amount when the oily base is used is, for example, 1 to 50% by mass, preferably 5 to 50% by mass, more preferably 5 to 5% by mass with respect to the total mass of the stick-like substrate to be obtained. It is 20% by mass, particularly preferably 10 to 20% by mass.
The oily base that can be used in the present invention is at least one of the above-mentioned oily base group, and these oily bases may be used alone or in combination of two or more.

[Pigment]
The stick-like substrate of the present invention may further contain a pigment. The pigment that can be blended is not particularly limited. For example, inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as red iron oxide (bengala) and iron titanate; γ-iron oxide and the like Inorganic yellow pigments such as yellow iron oxide and loess; inorganic black pigments such as black iron oxide and low-order titanium oxide; inorganic purple pigments such as mango violet and cobalt violet; chromium oxide and hydroxide Inorganic green pigments such as chromium and cobalt titanate; inorganic blue pigments such as ultramarine and bitumen; titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, fish scale Pearl pigments such as foil; talc, sericite, mica, kaolin, calcium carbonate, magnesium carbonate, silicic anhydride Body pigments such as barium sulfate and aluminum hydroxide; metal powder pigments such as aluminum powder, copper powder and gold; surface-treated inorganic and metal powder pigments; organic pigments such as zirconium, barium and aluminum lakes; surface-treated organic pigments and the like It is done.
In the present invention, when a pigment is blended, the blending amount is, for example, 1 to 50% by mass, preferably 5 to 50% by mass, and more preferably 6 to 20%, based on the total mass of the stick-like substrate to be obtained. % By mass, particularly preferably 10 to 20% by mass.
In addition, the said pigment used in this invention is at least 1 type of the above-mentioned pigment group, These pigments can be used individually by 1 type or in combination of 2 or more types.

[Organic acid]
The stick-like substrate of the present invention may further contain an organic acid.
Examples of the organic acid include ascorbic acid, citric acid, lactic acid, glycolic acid, succinic acid, acetic acid, malic acid, tartaric acid, and fumaric acid. Among them, ascorbic acid, citric acid, and lactic acid are preferable, and ascorbic acid and citric acid are particularly preferable.
In this invention, the compounding quantity in the case of using an organic acid is 1-20 mass% with respect to the total mass of the stick-shaped base material obtained, Preferably it is 1-10 mass%.

[Polyhydric alcohol]
The stick-like substrate of the present invention may further contain a polyhydric alcohol. The polyhydric alcohol is a polyhydric alcohol different from the 1,2-alkanediol or 1,3-alkanediol listed above, and specific examples thereof include glycerin, propylene glycol, and polyethylene glycol. By including the polyhydric alcohol, the temporal stability of the stick-like substrate can be improved. For example, polyethylene glycol having an average molecular weight of 1,000 to 4,000 can be preferably used.
In the present invention, when polyhydric alcohol is used, the blending amount can be, for example, 1 to 80% by mass, preferably 1 to 60% by mass, based on the total mass of the stick-like substrate to be obtained.

[Other additives]
The stick-like substrate of the present invention can be blended with additives that can generally be used as cosmetic additives, quasi-drug additives, and pharmaceutical additives as necessary. Examples of additive components such as physiologically active substances and functional substances that are blended in cosmetics, quasi-drugs, or pharmaceutical external preparations for skin include moisturizers, feel-improving agents, surfactants other than the above, solvents, and antioxidants. Agent, reducing agent, oxidizing agent, preservative, antibacterial agent, bactericidal agent, chelating agent, pH adjuster, acid, alkali, powder, inorganic salt, UV absorber, whitening agent, vitamins and derivatives thereof, for hair growth Drug, Blood circulation promoter, Stimulant, Hormones, Anti-wrinkle agent, Anti-aging agent, Tightening agent, Cool sensation agent, Warm sensation agent, Wound healing promoter, Stimulation mitigation agent, Analgesic agent, Cell activator, Plant / Animal・ Microbial extract, antipruritic agent, exfoliating / dissolving agent, antiperspirant, refreshing agent, astringent, enzyme, nucleic acid, fragrance, pigment, colorant, dye, anti-inflammatory agent, anti-inflammatory agent, anti-asthma, anti-chronic obstructive Examples include pulmonary diseases, antiallergies, immune regulators, antiinfectives and antifungals It is.
The blending amount of these other additives may vary depending on the type of the additive, but is, for example, about 0.1 to 20% by mass, or about 0.5 to 10% by mass with respect to the total mass of the obtained stick-shaped substrate. can do.

Examples of moisturizers / feel improvers include glycerin, trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol / propylene glycol copolymer and the like polyols and Polymers; glycol alkyl ethers such as diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether; (eicosane diacid / tetradecanedioic acid) polyglyceryl-10, tetradecane Water-soluble esters such as polyglyceryl-10; sorbitol, xylitol, erythritol, man Sugar alcohols such as tol and maltitol; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α -, Β-, γ-cyclodextrin and modified cyclodextrins such as maltosylation, hydroxyalkylation, etc.), β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabinogalactan, dextrin, dextran, glycogen, ethyl Sugars such as glucoside, glucosylethyl methacrylate polymer or copolymer, and derivatives thereof; hyaluronic acid, sodium hyaluronate; chondroitin sulfate sodium; mucoichi Sulfate, caronine sulfate, keratosulfate, dermatan sulfate; white jellyfish extract, white jellyfish polysaccharide; fucoidan; tuberose polysaccharide or naturally derived polysaccharide; organic acids such as citric acid, tartaric acid, lactic acid and their salts; urea and its derivatives; 2-pyrrolidone-5-carboxylic acid and salts thereof such as sodium; betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, Amino acids and their salts such as asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine; collagen, fish-derived collagen, atelocollagen, gelatin Elastin, collagen degrading peptide, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin degrading peptide, keratin degrading peptide, hydrolyzed keratin, conchiolin degrading peptide, hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk, lauroyl hydrolyzing Protein peptides such as silk sodium, soybean proteolytic peptide, wheat proteolytic peptide, hydrolyzed wheat protein, casein degrading peptide, acylated peptide and derivatives thereof; acylated peptides such as palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide Silylated peptides: Lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesameignan glycoside, glutathione, a Lubumin, whey; choline chloride, phosphorylcholine; placenta extract, aerostin, collagen, aloe extract, hamamelis water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, Izayoi rose extract, yarrow extract, eucalyptus extract Ceramides, such as animal and plant extract components such as merirot extract, natural ceramide (types 1, 2, 3, 4, 5, 6), hydroxyceramide, pseudoceramide, glycosphingolipid, ceramide and sugar ceramide-containing extract It is mentioned as preferable.

Preferred examples of the surfactant include an anionic surfactant, a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and a polymer surfactant. Examples of preferable surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfate esters such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; Polyoxyethylene alkyl sulfates such as sodium laureth sulfate and triethanolamine laureth sulfate; cocoyl methyl taurine sodium, cocoyl methyl taurine potassium, lauroyl methyl taurine sodium, myristoyl methyl taurine sodium, lauroyl methyl alanine sodium, lauroyl sarcosine sodium, lauroyl sarcosine tri Acyl N-methyl amino acid salts such as ethanolamine and sodium methylalanine lauroylglutamate; cocoyl Acyl amino acid salts such as sodium glutamate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, cocoylalanine triethanolamine; polyoxyethylene alkyl ethers such as sodium laureth acetate Acetic acid salt; Succinic acid ester salt such as sodium lauroyl monoethanolamide succinate; Fatty acid alkanolamide ether carboxylate; Acyl lactate; Polyoxyethylene fatty amine sulfate; Fatty acid alkanolamide sulfate; Hardened coconut oil fatty acid sodium glyceryl sulfate Fatty acid glyceride sulfate such as alkylbenzene polyoxyethylene sulfate; α-olefin Olefin sulfonates such as sodium sulfonic acid sulfonate; Alkyl sulfosuccinates such as disodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate; disodium laureth sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene sodium sodium sulfosuccinate, lauryl polypropylene glycol sulfosuccinic acid Alkyl ether sulfosuccinates such as sodium; alkylbenzene sulfonates such as sodium tetradecylbenzenesulfonate and triethanolamine tetradecylbenzenesulfonate; alkylnaphthalenesulfonates; alkanesulfonates; α-sulfo fatty acid methyl ester salts; Acyl isethionate; alkyl glycidyl ether sulfonate; alkyl sulfoacetate; laureth Alkyl ether phosphate salts such as sodium phosphate, sodium dilaureth phosphate, sodium trilaureth phosphate, sodium monooles phosphate; alkyl phosphate ester salts such as potassium lauryl phosphate; sodium caseinate; alkyl aryl ether phosphate; fatty acid amide Ether phosphates; Phospholipids such as phosphatidylglycerol, phosphatidylinositol, and phosphatidic acid; Silicone anionic surfactants such as carboxylic acid-modified silicone, phosphoric acid-modified silicone, and sulfuric acid-modified silicone; Nonionic surfactants These include laureth (polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steareth (polyoxyethylene stearyl ether), behenez (polyoxy). Polyoxyethylene alkyl ethers with various polyoxyethylene addition numbers such as silethylene behenyl ethers), isosteares (polyoxyethylene isostearyl ether) s, octyldecesses (polyoxyethylene octyldodecyl ethers); Ether: Polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearic acid diester Castor oil and hardened castor oil derivatives such as polyoxyethylene hydrogenated castor oil maleic acid; polyoxyethylene phytosterol; polyoxyethylene cholesterol Polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene / polyoxypropylene cetyl ether, polyoxyethylene / polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene / polyoxypropylene monobutyl ether Polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene glycerin ether and other polyoxyethylene / polyoxypropylene alkyl ethers; polyoxyethylene / polyoxypropylene glycol; PPG-9 diglyceryl and the like ( Poly) glycerin polyoxypropylene glycol; glyceryl stearate, glyceryl isostearate, glyceryl palmitate, milli Glyceryl fatty acid partial esters such as glyceryl tinate, glyceryl oleate, glyceryl coconut oil fatty acid glyceryl, mono-cotton oil fatty acid glycerin, glyceryl monoerucate, glyceryl sesquioleate, glycerin α, α'-oleic acid pyroglutamate, glyceryl monostearate Polyglyceryl stearate-2, 3, 4, 5, 6, 8, 10, 10 polyglyceryl-6 distearate, 10, polyglyceryl tristearate, polyglyceryl decastearate-10, isostearin Polyglyceryl-2, 3, 4, 5, 6, 8, 10, diisostearate polyglyceryl-2 (diglyceryl diisostearate), 3, 10, polyglyceryl-2 triisostearate, tetraisostearate Polyglyceryl-2, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, 3, 4, 5, 6, 8, 10, dioleate polyglyceryl-6, trioleate polyglyceryl-2, dekaoleic acid Polyglyceryl fatty acid esters such as polyglyceryl-10; ethylene glycol monofatty acid esters such as ethylene glycol monostearate; propylene glycol monofatty acid esters such as propylene glycol monostearate; pentaerythritol partial fatty acid esters; sorbitol partial fatty acid esters; maltitol moieties Fatty acid ester; maltitol ether; sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbi Monostearate, sorbitan sesquioleate, sorbitan trioleate, penta-2-ethylhexyl diglycerol sorbitan, tetra-2-ethylhexyl diglycerol sorbitan, etc .; sucrose fatty acid ester, methyl glucoside fatty acid ester, undecylene Sugar derivative partial ester such as acid trehalose; alkyl glucoside such as caprylyl glucoside; alkyl polyglycoside; lanolin alcohol; reduced lanolin; polyoxyethylene distearate, polytylene glycol diisostearate, polyoxyethylene monooleate, poly Polyoxyethylene fatty acid mono- and diesters such as oxyethylene dioleate; polyoxyethylene propylene glycol fatty acid ester; Polyoxyethylene glycerol fatty acid esters such as polyoxyethylene monooleate such as xylethylene glycerol monostearate, polyoxyethylene glycerol monoisostearate, polyoxyethylene glycerol triisostearate; polyoxyethylene sorbitan monooleate, poly Polyoxyethylene sorbitan fatty acid esters such as oxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol Polyoxyethylene sorbitol such as pentaoleate and polyoxyethylene sorbitol monostearate Fatty acid ester; Polyoxyethylene methyl glucoside fatty acid ester; Polyoxyethylene alkyl ether fatty acid ester; Polyoxyethylene animal and vegetable fats and oils such as polyoxyethylene sorbitol beeswax; Isostearyl glyceryl ether, Kimyl alcohol, Serakyl alcohol, Batyl alcohol, etc. Polyglyceryl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponins and sophorolipids; polyoxyethylene fatty acid amides; Palm oil fatty acid monoethanolamide (cocamide MEA), palm oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (Lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), palm oil fatty acid methylethanolamide ( Fatty acid alkanolamides such as cocamidomethyl MEA); alkyldimethylamine oxides such as lauramine oxide, cocamamine oxide, stearamine oxide, and behenamine oxide; alkylethoxydimethylamine oxide; polyoxyethylene alkyl mercaptan; dimethicone copolyol, etc. Polyether-modified silicone, polysiloxane / oxyalkylene copolymer, polyglycerin-modified silicone, sugar-modified silicone, etc. Nonionic surfactants of silicone, etc .; cationic surfactants include alkyltrimethylammonium chlorides such as behentrimonium chloride, steartrimonium chloride, cetrimonium chloride, lauryltrimonium chloride; stearyltrimonium bromide, etc. Alkyltrimethylammonium bromides; dialkyldimethylammonium chlorides such as distearyldimonium chloride and dicocodimonium chloride; fatty acid amidoamines and salts thereof such as stearamidepropyldimethylamine and stearamideethyldiethylamine; alkyl ethers such as stearoxypropyldimethylamine Amines and salts or quaternary salts thereof; ethyl sulfate long chain branched fatty acid (12-31) aminopropylethyldimethylammonium Fatty acid amide type quaternary ammonium salts such as lanolin fatty acid aminopropylethyldimethylammonium; polyoxyethylene alkylamines and salts or quaternary salts thereof; alkylamine salts; fatty acid amidoguanidinium salts; alkyl etheraminemonium salts; Benzalkonium salts; benzethonium salts; pyridinium salts such as cetylpyridinium chloride; imidazolinium salts; alkylisoquinolinium salts; dialkyl morpholinium salts; polyamine fatty acid derivatives; aminopropyl dimethicone and amodimethicone, etc. Silicone-based cationic surfactants such as amino-modified silicone, cation-modified silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone Examples of the amphoteric surfactant; etc
N-alkyl-N, N-dimethylamino acid betaines such as lauryl betaine (lauryldimethylaminoacetic acid betaine); fatty acid amide alkyl-N, N-dimethylamino acid betaines such as cocamidopropyl betaine and lauramidopropyl betaine; sodium cocoamphoacetate; Imidazoline-type betaines such as sodium lauroamphoacetate; alkylsulfobetaines such as alkyldimethyltaurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate; phosphate-type betaines such as alkyldimethylaminoethanol phosphate; phosphatidylcholine, phosphatidylethanolamine, Sphingophospholipids such as phosphatidylserine and sphingomyelin, lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogen Egg yolk phospholipids, partially hydrogenated egg yolk phospholipids, phospholipids such as hydroxylated lecithin; silicone-based amphoteric surfactants; polymer surfactants include polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, acrylic acid -Alkyl methacrylate copolymers; various silicone surfactants are preferred.

Solvents include lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol and isobutyl alcohol; glycols such as propylene glycol, diethylene glycol, dipropylene glycol and isopentyl diol; diethylene glycol monoethyl ether (ethoxydiglycol) , Glycol ethers such as ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether; ethylene glycol monoethyl ether Acetate, diethylene glycol Glycol ether esters such as ethyl ether acetate and propylene glycol monoethyl ether acetate; glycol esters such as diethoxyethyl succinate and ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, acetic acid Preferred examples include ethyl, N-methylpyrrolidone and toluene.

Antioxidants include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or derivatives thereof; erythorbic acid and derivatives thereof; Preferred are sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride As mentioned.

Preferred examples of the reducing agent include thioglycolic acid, cysteine, cysteamine and the like.

Preferred examples of the oxidizing agent include hydrogen peroxide water, ammonium persulfate, sodium bromate, percarbonate, and the like.

Examples of preservatives, antibacterial agents, and bactericides include hydroxybenzoic acid such as methylparaben, ethylparaben, propylparaben, and butylparaben, and salts or esters thereof; salicylic acid; sodium benzoate; phenoxyethanol; methylchloroisothiazolinone, methylisothiazo Isothiazolinone derivatives such as linone; imidazolinium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzalkonium chloride, chloride Benzethonium, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, hinokitiol; phenol, isopropylphenol, cresol, Mall, para chlorophenol, phenylphenol, other phenols such as phenylphenol sodium; phenylethyl alcohol, photosensitive Motorui, be mentioned as antibacterial zeolite, silver ion.

Examples of chelating agents include edetate (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; Phosphonic acid and its sodium salt; polyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine, gluconic acid, Ascorbic acid, succinic acid and tartaric acid are preferred.

pH adjusters / acids / alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, potassium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid , Monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine Sodium hydroxide, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate are preferable.

Examples of powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, saucite, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, and silicic acid. Barium, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorine apatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, metal Soap (eg, zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, bengara, yellow iron oxide, black iron oxide, ultramarine, bitumen, carbon black, titanium oxide, fine particles and super Titanium oxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silica), mica titanium, fish scale foil, boron nitride, photochromic pigment, synthetic fluorophlogopite, fine particle composite powder Body, gold, aluminum, etc., various sizes and shapes of inorganic powders, and these are treated with various surface treatment agents such as hydrogen silicone, cyclic hydrogen silicone, or other silane or titanium coupling agents Inorganic powders such as hydrophobized or hydrophilized powders; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, polyester powder, Benzoguanamine resin powder, polyethylene terephthalate polymer Organic powders and surface-treated powders of various sizes and shapes, such as polyurethane powder, polyethylene terephthalate / aluminum / epoxy powder, urethane powder, silicone powder, Teflon (registered trademark) powder, organic-inorganic composite powder The body is preferred.

Inorganic salts include sodium chloride-containing salts such as salt, common salt, rock salt, sea salt, natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, Aluminum sulfate / potassium sulfate (alum), aluminum sulfate / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na, 2Na and 3Na phosphates, phosphoric acid Potassium, calcium phosphates and magnesium phosphates are preferred.

Examples of ultraviolet absorbers include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, and N, N-dimethylparaaminobenzoic acid ethyl ester. Benzoic acid ultraviolet absorbers such as esters, N, N-dimethylparaaminobenzoic acid butyl ester, N, N-dimethylparaaminobenzoic acid methyl ester; Anthranilic acid ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; Salicylic acid And salicylic acid systems such as sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate External line absorbent: octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p- Methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-ethylhexyl-p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (sinoxate) Cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate (octocrine), glyceryl mono-2-ethylhexanoyl-diparame Cinnamic acid UV absorbers such as toxicinnamate, ferulic acid and derivatives thereof; 2,4-dihydroxybenzophenone, 2,2′-dihydroxy-4-methoxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxy Benzophenone, 2,2 ′, 4,4′-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4′-methylbenzophenone, 2-hydroxy-4- Methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4′-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone Benzofe etc. UV absorbers; 3- (4′-methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2′-hydroxy- 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole; 2- (2′-hydroxy-5′-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyl triazone; urocanic acid such as urocanic acid and ethyl urocanate Derivatives; 2- (2′-hydroxy-5′-methylphenyl) benzotriazole Hydantoin derivatives such as 1- (3,4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentanedione, dimethoxybenzylidenedioxoimidazolidinepropionate 2-ethylhexyl, phenylbenzimidazolazolesulfonic acid, terephthalate Preference is given to liridene dicamphorsulfonic acid, drometrizol trisiloxane, methyl anthranilate, rutin and its derivatives, oryzanol and its derivatives.

Examples of whitening agents include hydroquinone glycosides such as arbutin and α-arbutin and their esters; ascorbic acid phosphates such as ascorbic acid, sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate, ascorbic acid Ascorbic acid fatty acid esters such as tetraisopalmitic acid ester, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucosides such as ascorbic acid-2-glucoside and fatty acid esters thereof, ascorbic acid sulfate ester, tocopheryl ascorbyl phosphate Ascorbic acid derivatives such as kojic acid, ellagic acid, tranexamic acid and its derivatives, ferulic acid and its derivatives, placenta extract, glutathione, oryzanol, butylreso Shinoru, oil-soluble Kamomiraekisu, oil-soluble licorice extract, Nishikawa willow extract, be mentioned as saxifrage extract, and the like plant extracts are preferred.

Vitamins and their derivatives include vitamin A such as retinol, retinol acetate, retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, Flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid such as nicotinic acid amide / benzyl nicotinate, vitamin B group such as choline; vitamin C such as ascorbic acid and its sodium salt; vitamin D; α, Vitamin E such as β, γ, and δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphates such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt, Ascorbic acid fatty acid esters such as ascorbyl tetraisopalmitate, ascorbyl stearate, ascorbyl palmitate and ascorbyl dipalmitate, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucosides such as ascorbic acid-2-glucoside and Ascorbic acid derivatives such as fatty acid esters and tocopheryl phosphate ascorbyl; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol acetate, tocopherol linoleate, tocopherol phosphate, tocopherol phosphate etc., tocotrienol, and other various vitamin derivatives Is preferable.

Plant extracts and tinctures such as assembly extract, red pepper tincture, ginger tincture, ginger extract, cantalis tincture; capsaicin, nonylic acid vanillylamide, gingeron, ictamol, tannic acid Borneol, cyclandrate, cinnarizine, trazoline, acetylcholine, verapamil, cephalanthin, γ-oryzanol, vitamin E and derivatives such as nicotinic acid tocopherol / acetic acid tocopherol, nicotinic acid and nicotinic acid amide / nicotinic acid benzyl ester / inositol hexanicotinate Derivatives of nicotine alcohol, allantoin, photosensitive element 301, photosensitive element 401, capronium chloride, pentadecanoic acid monoglyceride, flavonol derivative, stigma Terol or stigmastanol and glycosides thereof, and the like as minoxidil are preferred.

Preferred examples of hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like. Other remedies such as anti-wrinkle agents, anti-aging agents, squeeze agents, cooling sensations, warming sensation agents, wound healing promoters, irritation relievers, analgesics, cell activators include retinols, retinoic acids, retinoin Acid tocopheryl; derivatives such as lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and glycosides / esterified products thereof, α- or such as hydroxycapric acid, long chain α-hydroxy fatty acid, long chain α-hydroxy fatty acid cholesteryl β-hydroxy acids and derivatives thereof; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosines; caffeine, xanthine and the like; coenzyme Q10, carotene, lycopene , Astaxanthin, lutein, α-lipoic acid, platinum nanocolloid, fullerenes, etc. Antioxidant / active oxygen scavengers; catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamin, protoanthocyanidin, chlorogenic acid, apple polyphenol; rutin and glycosides, etc. Derivatives of hesperidin and glycosides; lignan glycosides; licorice extract-related substances such as grabrizine, glabrene, liquiritin, and isoliquiritin; lactoferrin; shogaol, gingerol; and fragrance substances such as menthol and cedrol; And insecticides such as diethyl toluamide; complexes of physiologically active substances and cyclodextrins are preferred.

Plant / animal / microbe extracts include iris extract, ashitaba extract, asunalo extract, asparagus extract, avocado extract, achacha extract, almond extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo biloba extract , Carrot extract, fennel extract, turmeric extract, oolong tea extract, walrus extract, ages extract, echinacea leaf extract, enmeo extract, peony extract, duckweed extract, lauren extract, barley extract, ginseng extract, hypericum extract, licorice extract, Onionis extract, Dutch mustard extract, orange extract, dried seawater, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, water Denatured silk, cocoon extract, chamomile extract, oil-soluble chamomile extract, carrot extract, kawarayomigi extract, oat extract, calcade extract, licorice extract, oil-soluble licorice extract, kiwi extract, kiou extract, jellyfish extract, quina extract, cucumber extract, giraffe leaf extract , Guanosine, guava extract, kudin extract, gardenia extract, kumazasa extract, clara extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, mulberry extract, gentian extract, gentian pepper extract, Black tea extract, yeast extract, kokuboku extract, coffee extract, burdock extract, rice extract, rice fermented extract, rice bran fermented extract, rice germ oil, comfrey exhaust Collagen extract Citrus extract, jatoba extract, peonies extract, ginger cucumber extract, ginger root extract, white birch extract, white jellyfish extract, horsetail extract, stevia extract, stevia fermented product, Nishikawa willow extract, Atlantic kizuta extract, hawthorn extract, elderberry extract, yarrow Extract, mint extract, sage extract, mallow extract, nematode extract, assembly extract, Sakuhakuhi extract, Diou extract, Soybean extract, tiso extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, chigaya extract, chimpi extract, tea tree oil, strawberry tea extract, red pepper extract, suzuki extract, eucalyptus extract, tonin extract, spruce extract, dokudami extract, tomato Extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, bacmond extract, lotus extract, parsley extract, birch extract, honey, hamamelis extract, parietalia extract, hyacinth extract, bisabolol, cypress extract, bifidobacteria extract, Loquat extract, dandelion extract, burdock extract, bukkuri extract, butcher bloom extract, grape extract, grape seed extract, propolis, loofah , Safflower extract, peppermint extract, body extract, button extract, hop extract, squid extract, pine extract, maroni extract, citrus extract, mugwort extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, yukinoshita extract, yuzu extract, Lily extract, Yokuinin extract, Artemisia extract, Lavender extract, Green tea extract, Egg shell membrane extract, Apple extract, Rooibos tea extract, Ganoderma extract, Lettuce extract, Lemon extract, Forsythia extract, Forsythia extract, Rose extract, Rosemary extract, Roman chamomile extract Extracts such as royal jelly extract and walnut extract are preferred.

Examples of antipruritic agents include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor, and the like.

Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine and the like.

Examples of antiperspirants include chlorohydroxyaluminum, aluminum chloride, zinc oxide, zinc paraphenol sulfonate, and the like.

Examples of the refreshing agent include menthol and methyl salicylate.

Examples of astringents include citric acid, tartaric acid, lactic acid, aluminum sulfate / potassium, and tannic acid.

Enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, and the like.

Preferred nucleic acids include ribonucleic acid and its salts, deoxyribonucleic acid and its salts, and adenosine triphosphate disodium.

As perfumes, acetyl cedrene, amylcinnamaldehyde, allyl amyl glycolate, β-ionone, iso-Esuper, isobutyl quinoline, Iris oil, Iron, indole, ylang ylang oil, undecanal, undecenal, γ-undecalactone, Estragole, eugenol, oak moss, opoponax resinoid, orange oil, eugenol, auranthiol, galac solid, carvacrol, L-carvone, camphor, cannon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile , Isobornyl acetate, geranyl acetate, dimethylbenzyl carvinyl acetate, styraryl acetate, cedolyl acetate, terpinel acetate, pt-butylcyclohexyl acetate, vetiberyl acetate, benzyl acetate Linalyl acetate, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromyrsenol, jasmine absolute, jasmine lactone, cis-jasmon, citral, citronenol, Citronellal, cinnamon bark oil, 1,8-cineole, cinnamaldehyde, stylus resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascon, damasenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ- Terpinene, triplar, nerol, nonanal, 2,6-nonadienol, nonalactone, patchouli alcohol, vanilla Solute, vanillin, basil oil, patchouli oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitglen oil, hexylcinnamaldehyde, cis-3-hexenol, perubalsum, vetiver oil, vetiverol, peppermint oil , Pepper oil, heliotropin, bergamot oil, benzylbenzoate, borneol, milresinoid, musk ketone, methylnonylacetaldehyde, γ-methylyonone, menthol, L-menthol, L-menton, eucalyptus oil, β-yonone, lime oil, lavender oil Synthetic and natural flavors such as D-limonene, linalool, linal, rillial, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, and various essential oils In addition, various kinds of blended fragrances are preferable.

As pigments / colorants / dyes, brown 201, black 401, purple 201, purple 401, blue 1, blue 2, blue 201, blue 202, blue 203, blue 204, blue 205, Blue 403, Blue 404, Green 201, Green 202, Green 204, Green 205, Green 3, Green 401, Green 402, Red 102, Red 104-1, Red 105-1, Red 106, Red 2, Red 201, Red 202, Red 203, Red 204, Red 205, Red 206, Red 207, Red 208, Red 213, Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228, Red 230-1 Red 230-2, Red 231, Red 232, Red 3, Red 401, Red 404, Red 404, Red 405, Red 501, Red 502, Red 503, Red 504, Red 505 Red No. 506, Orange No. 201, Orange No. 203, Orange No. 204, Orange No. 205, Orange No. 206, Orange No. 207, Orange No. 401, Orange No. 402, Orange No. 403, Yellow No. 201, Yellow No. 202-1 Yellow 202-2, Yellow 203, Yellow 204, Yellow 205, Yellow 4, Yellow 401, Yellow 402, Yellow 403-1, Yellow 404, Yellow 405, Yellow 406, Yellow Legal pigments such as No. 407 and Yellow No. 5; Other acidic dyes such as Acid Red 14; Aryanor Sienna Brown, Aryanor Madder Red, Ari Basic dyes such as nor Steel Blue, Aryanor Straw Yellow, etc .; HC Yellow 2, HC Yellow 5, HC Red 3, 4-hydroxypropylamino-3-Ntrobisphenol, N, N'-bis (2-hydroxyethyl-2) Nitro dyes such as phenylenediamine, HC Blue 2, Basic Blue 26; disperse dyes; anthraquinones such as astaxanthin and alizarin, anthocyanidins, β-carotene, catenal, capsanthin, chalcone, calsamine, quercetin, crocin, chlorophyll, curcumin, cochineal, cochineal Naphthoquinones such as bixin, flavones, betacyanidine, henna, hemoglobin Natural pigments and dyes such as glycine, lycopene, riboflavin and rutin; p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylenediamine, 5-amino-2- Preferable examples include oxidative dye intermediates and couplers such as methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine, and salts thereof; auto-oxidative dyes such as indoline; and dihydroxyacetone.

Anti-inflammatory / anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, ketoprofen, ibuprofen, diclofenac, loxoprofen, celecoxib, infliximab, etanercept, zinc oxide, hydroacetic acid, zinc acetate, Preferred examples include prednisone, diphedramine hydrochloride, chlorpheniramine maleate; and plant extracts such as peach leaf extract and persimmon leaf extract.

Anti-asthma, anti-chronic obstructive pulmonary disease, anti-allergy, immunomodulators include aminophylline, theophylline, steroids (fluticasone, beclomethasone, etc.), leukotriene antagonists, thromboxane inhibitors, intal, β2-stimulant (Formoterol, salmeterol, albuterol, tulobuterol, clenbuterol, epinephrine, etc.), tiotropium, ipratropium, dextromethorphan, dimemorphan, bromhexine, tranilast, ketotifen, azelastine, cetirizine, chlorpheniramine, polyquitolsine, Preferred examples include cytokine regulators, interferons, omalizumab, and protein / antibody preparations.

Preferred examples of the anti-infective and antifungal agents include oseltamivir, zanamivir, and itraconazole. In addition to these, cosmetic raw material standards, cosmetic ingredient-specific combination ingredient standards, Japan Cosmetic Industry Association ingredient display name list, INCI dictionary (The International Cosmetic Ingredients and Handbooks), quasi-drug ingredients standards, Japanese pharmacopoeia, pharmaceutical additive standards Ingredients listed in the Food Addendum, etc., and the international patent classification IPC described in Japan and other foreign patent gazettes and patent publications (including publications and republications) belonging to the A61K7 and A61K8 classifications It is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., in known combinations, blending ratios and blending amounts.

[Production method of stick-like substrate]
The stick-like substrate of the present invention comprises a lipid peptide compound comprising at least one of the compounds represented by the formulas (1) to (3) or a pharmaceutically usable salt thereof, a surfactant and water, 1,2-alkanediol or 1,3-alkanediol, higher alcohol, thickener and, if necessary, an oily base, pigment, and other additives, mixed and stirred with heating, then allowed to stand It can be manufactured by cooling.

For example, the stick-shaped substrate of the present invention is produced by the following process as an example.
a) a step of blending the above-mentioned lipid peptide compound, a surfactant and water, and preparing a solution or dispersion by heating;
b) adding the solution or dispersion to water and heating at a temperature of room temperature to less than 100 ° C .;
c) The process which cools with stirring until it becomes temperature lower than the temperature in the said heating process, and is left still standing to cool, and forms a gel-like solid substance (stick-shaped base material).
Here, 1,2-alkanediol or 1,3-alkanediol, oily base, higher alcohol, thickener, pigment and other additives are added in the step of preparing the solution or dispersion in step a). Alternatively, it may be added in advance to the water to which the solution or dispersion is added in step b).
Moreover, it is preferable that water is 20 mass% or more and less than 99 mass% with respect to the total mass of the obtained stick-shaped base material.
Moreover, it is preferable that water is 30 to 80 mass% with respect to the total mass of the obtained solution or dispersion.

The heating temperature in the step a) and the step b) is preferably 50 ° C. to 90 ° C., more preferably 60 ° C. to 90 ° C., for example 80 ° C., and stirring is preferably performed while heating. The time of heating and stirring in each step at this time varies depending on the type of lipid peptide compound used, the surfactant and other components, and the blending amount thereof, but can usually be dissolved and dispersed in about 5 to 50 minutes. .
Following steps a) and b), cooling is performed with stirring until the liquid temperature is lower than the temperature in step b) (step c). Here, the cooling temperature is, for example, room temperature to 80 ° C., room temperature to 60 ° C., or room temperature to 40 ° C.

Moreover, after manufacturing the aqueous composition which is a premix, the stick-shaped base material of this invention can also be manufactured by adding suitably another compounding component to this premix.
For example, the following is mentioned as a manufacturing method of the stick-shaped base material which passed through the premix.
1) Step of preparing a premix 1-1) A surfactant and water, and at least one of the compounds represented by the formulas (1) to (3) or a pharmaceutically usable salt thereof. A heating step of heating a mixed system containing the lipid peptide type compound to a temperature of room temperature to less than 100 ° C .;
1-2) Subsequently, a step of appropriately adding 1,2-alkanediol or 1,3-alkanediol and other additives to the heated mixed system,
1-3) A preparation step of cooling the solution or dispersion to obtain an aqueous composition (premix),
2) Step of producing stick-like substrate using premix 2-1) The aqueous composition (pre-heated) heated to a temperature of room temperature to less than 100 ° C. in an aqueous phase heated to a temperature of room temperature to less than 100 ° C. (Mix) is added and mixed, or an aqueous phase heated to a temperature of room temperature to less than 100 ° C. is added to and mixed with the aqueous composition (premix) heated to a temperature of room temperature to less than 100 ° C. , Mixing process,
2-2) A cooling step in which the mixture obtained in the mixing step is cooled to form a stick-like substrate (gel).
The aqueous phase in the step 2-1) contains water, and may further contain an oily base, a higher alcohol, a thickener, a pigment, and 1,2-alkanediol or 1,3-alkanediol, and other additives. May be included. Further, in 2-1), a pigment and other additives may be mixed with the aqueous composition (premix) and then combined with the aqueous phase.
Furthermore, in the said mixing process, the stick-shaped base material (formulation) which added the chemical | medical agent can also be manufactured by adding the chemical | medical agent solution.

The heating temperature of the mixed system (and aqueous composition) in the steps 1-1) and 1-2) is preferably 50 ° C. to 90 ° C., more preferably 60 ° C. to 90 ° C., for example 70 ° C., or 80 ° C. It is. This step is preferably carried out with stirring. The time of heating (stirring) in each step at this time is usually about 5 to 50 minutes, although it varies depending on the type of lipid peptide compound, surfactant and other components contained in the aqueous composition, and their blending amount. . By this step, the aqueous composition is uniformly dissolved.
The cooling temperature in the step 1-3) is, for example, room temperature to 80 ° C., room temperature to 60 ° C., or room temperature to 40 ° C. In this step, it is more preferable to cool with stirring, then stop stirring and leave to stand.
In addition, it is preferable that water is 30 mass% or more and less than 80 mass% with respect to the total mass of the aqueous composition (premix) obtained by the 1) process.

In the step 2-1), the heating temperature of the aqueous phase and the aqueous composition (premix) is preferably 50 ° C. to 90 ° C., more preferably 60 ° C. to 90 ° C., such as 70 ° C., or 80 ° C., or 90 ° C. It is. The aqueous phase is preferably heated with stirring because it contains other components such as an oily base. Heating (stirring) is usually carried out for about 5 to 50 minutes until the contained components are uniformly dissolved and dispersed. It is preferable to do. The heating temperature of the aqueous phase may be the same as the heating temperature of the aqueous composition (premix).

Subsequently, in the step 2-2), the mixture obtained in the previous step is cooled to form a gel-like solid (stick-like substrate). At this time, the mixture may be cooled with stirring. In the case of cooling with stirring, it is preferable to carry out stirring until the cooling temperature reaches room temperature to 80 ° C., room temperature to 60 ° C., for example, about 60 ° C., and then stop the stirring and leave it to cool. In particular, at 50 ° C. or less, it is preferable to stop stirring and leave it to cool.

Even in the stick-shaped substrate thus obtained using the aqueous composition (premix), the blending amount of water may be 20% by mass or more and less than 99% by mass with respect to the total mass of the stick-shaped substrate. preferable.

Hereinafter, the present invention will be described in detail by way of examples and test examples, but the present invention is not limited to these examples.

[Synthesis Example 1: Synthesis of lipid peptide (N-palmitoyl-Gly-His)]
The lipid peptide type compound used in this example was synthesized by the following method.
A 500 mL four-necked flask was charged with 14.2 g (91.6 mmol) of histidine, 30.0 g (91.6 mmol) of N-palmitoyl-Gly-methyl and 300 g of toluene, and a sodium methoxide 28% methanol solution as a base. 35.3 g (183.2 mmol) was added, and the mixture was heated to 60 ° C. in an oil bath and stirred for 1 hour. Thereafter, the oil bath was removed and the mixture was allowed to cool to 25 ° C. This solution was reprecipitated with 600 g of acetone and collected by filtration. The solid obtained here was dissolved in a mixed solution of 600 g of water and 750 g of methanol, and 30.5 ml (183.2 mmol) of 6N hydrochloric acid was added thereto for neutralization to precipitate a solid, followed by filtration. Next, the obtained solid was dissolved in a mixed solution of 120 g of tetrahydrofuran and 30 g of water at 60 ° C., 150 g of ethyl acetate was added, and the mixture was cooled from 60 ° C. to 30 ° C. Thereafter, the precipitated solid was filtered. Further, the obtained solid was dissolved in 120 g of tetrahydrofuran and 60 g of acetonitrile, heated to 60 ° C., stirred for 1 hour, cooled, and filtered. The solid obtained here was washed with 120 g of water, dried under reduced pressure after filtration, and 26.9 g (yield 65) of white crystals of N-palmitoyl-Gly-His free form (hereinafter also simply referred to as “Pal-GH”). %).

[Examples 1 to 4 and Comparative Examples 1 to 3]
(Premix preparation method)
According to Table 1 below, each component was sample tube No. Weighed to 5. The pre-mix was prepared by heating the weighed composition to 70 ° C. or higher and dissolving it uniformly.

(Preparation method of stick-like substrate)
In accordance with the following Table 2, each component of the A phase or the above-mentioned premix is sample tube No. Weighed to 5. The weighed phase A was heated to 70 ° C. or higher and dissolved uniformly. On the other hand, another sample tube No. 5 was weighed 5.0 g of water as B phase and heated to 70 ° C. or higher. Thereafter, the A phase was added to the B phase, mixed in a heated state and stirred for about 30 seconds, and then allowed to stand and cool.

(Break strength measurement method)
Using YAMADEN RHEONER II CREEP METER RE2-30005B (Sanden Co., Ltd.), measurement speed: 0.5 mm / second, measurement distortion: 20%, storage pitch: 0.10 second, jig: 30349-3 The breaking strength was measured.
The obtained results are shown in Table 2.

As shown in Table 1, the solid base materials for external application of Examples 1 to 4 have a breaking strength: 0.4 to 1.3 × 10 ⁵ Pa, and have the strength required particularly as a stick-shaped base material. Had.

Claims (8)

One or more surfactants selected from the group consisting of betaine compounds and ethylene glycol alkyl ethers;
water and,
A lipid peptide type compound comprising at least one of the compounds represented by the following formulas (1) to (3) or a pharmaceutically usable salt thereof;
At least one saturated or unsaturated monohydric alcohol having 8 to 30 carbon atoms;
One or more thickeners selected from the group consisting of alginic acid derivatives and carrageenan,
A stick-like substrate.

(In the formula, R ¹ represents an aliphatic group having 9 to 23 carbon atoms, and R ² represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms. R ³ represents a — (CH ₂ ) _n —X group, n represents a number of 1 to 4, X represents an amino group, a guanidino group, a —CONH ₂ group, or 1 to 3 nitrogen atoms. And represents a condensed heterocyclic ring composed of a 5-membered ring or a 6-membered ring or a 5-membered ring and a 6-membered ring.)

(Wherein R ⁴ represents an aliphatic group having 9 to 23 carbon atoms, and R ^{5 to} R ⁷ each independently represents a hydrogen atom or a carbon atom having a branched chain having 1 or 2 carbon atoms. 1 to 4 alkyl groups or — (CH ₂ ) _n —X group, n represents a number of 1 to 4, and X represents an amino group, a guanidino group, a —CONH ₂ group, or a nitrogen atom of 1 to 3 This represents a 5-membered ring or 6-membered ring which may have one or a condensed heterocyclic ring composed of a 5-membered ring and a 6-membered ring.)

(In the formula, R ⁸ represents an aliphatic group having 9 to 23 carbon atoms, and R ^{9 to} R ¹² each independently represents a hydrogen atom, or a carbon atom number that can have a branched chain having 1 or 2 carbon atoms. 1 to 4 alkyl, or - (CH _{2) n} represents an -X group, n represents a number from 1 to 4, X is an amino group, a guanidino group, -CONH ₂ group, or a nitrogen atom and 1 to 3 This represents a 5-membered ring or 6-membered ring which may have one or a condensed heterocyclic ring composed of a 5-membered ring and a 6-membered ring.) The stick-shaped substrate according to claim 1, wherein the surfactant is ethylene glycol alkyl ether. The stick-like substrate according to claim 1, further comprising 1,2-alkanediol or 1,3-alkanediol. The stick-shaped substrate according to claim 3, wherein the alginic acid derivative is an alginate polyhydric alcohol ester. The thickener according to any one of claims 1 to 4, wherein the thickener is contained in a proportion of 0.1 to 1.0% by mass based on the total mass of the stick-like substrate. Stick-like substrate. The stick-shaped substrate according to any one of claims 3 to 5, wherein the betaine compound is a sulfuric acid type betaine. The stick-shaped substrate according to any one of claims 1 to 6, wherein the monohydric alcohol is one or more compounds selected from the group consisting of myristyl alcohol, cetanol, stearyl alcohol, and behenyl alcohol. . The stick according to any one of claims 1 to 7, wherein the lipid peptide-type compound is contained in a proportion of 0.1 to 2% by mass based on the total mass of the stick-like substrate. Substrate.