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WO2018207947A1 - Matériau de base en forme de bâtonnet contenant un polysaccharide - Google Patents

Matériau de base en forme de bâtonnet contenant un polysaccharide Download PDF

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Publication number
WO2018207947A1
WO2018207947A1 PCT/JP2018/018558 JP2018018558W WO2018207947A1 WO 2018207947 A1 WO2018207947 A1 WO 2018207947A1 JP 2018018558 W JP2018018558 W JP 2018018558W WO 2018207947 A1 WO2018207947 A1 WO 2018207947A1
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WIPO (PCT)
Prior art keywords
group
acid
extract
stick
gly
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English (en)
Japanese (ja)
Inventor
鷹行 井本
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Nissan Chemical Corp
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Nissan Chemical Corp
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Priority to JP2019517738A priority Critical patent/JPWO2018207947A1/ja
Publication of WO2018207947A1 publication Critical patent/WO2018207947A1/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present invention relates to a stick-shaped substrate containing a lipid peptide-type compound, and in particular, a stick-shaped substrate that can have a breaking strength required as a stick-shaped substrate even if the amount of the lipid peptide-type compound is reduced.
  • materials e.g.
  • the aqueous solid composition provides a high refreshing feeling when applied to the skin, etc., and has no stickiness after use as compared to the oily solid composition, so that it has a smooth use feeling.
  • a variety of products are marketed and proposed.
  • As an aqueous solid composition conventionally, a solid oil-in-water makeup cosmetic (Patent Document 1) containing water, fatty acid soap, oil and powder, an alkyl and / or alkenyl oligoglycoside, an oily substance, and a nonionic emulsifier
  • Patent Document 2 A stick-like water-based cosmetic
  • an aqueous gel composition is mentioned as a kind of aqueous solid composition.
  • various compounds such as a polymer gelling agent and a low molecular gelling agent have been proposed.
  • lipid peptide type low molecular gelling agents that have high biological safety and are expected to be developed into medical materials have been proposed.
  • the stick-shaped substrate described in Patent Document 3 uses about 5% by mass of the lipid peptide type compound based on the total mass of the stick-shaped substrate.
  • the lipid peptide type compound is expensive, and therefore, A stick-like substrate capable of reducing the amount of lipid peptide type compound is desired. Accordingly, an object of the present invention is to provide a stick-like substrate that can have the breaking strength required as a stick-like substrate even if the amount of the lipid peptide type compound is reduced.
  • lipid peptide type compound comprising a low-molecular-weight lipid peptide or a pharmaceutically usable salt thereof and water as main constituent components
  • a specific surfactant and a specific thickening agent are blended to have the breaking strength required as a stick-like base material even if the amount of lipid peptide type compound is reduced.
  • the present invention was completed.
  • the present invention provides the first aspect as follows: One or more surfactants selected from the group consisting of betaine compounds and ethylene glycol alkyl ethers; water and, A lipid peptide type compound comprising at least one of the compounds represented by the following formulas (1) to (3) or a pharmaceutically usable salt thereof; At least one saturated or unsaturated monohydric alcohol having 8 to 30 carbon atoms; One or more thickeners selected from the group consisting of alginic acid derivatives and carrageenan, The present invention relates to a stick-like substrate.
  • R 1 represents an aliphatic group having 9 to 23 carbon atoms
  • R 2 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms
  • R 3 represents a — (CH 2 ) n —X group, n represents a number of 1 to 4, X represents an amino group, a guanidino group, a —CONH 2 group, or 1 to 3 nitrogen atoms.
  • R 4 represents an aliphatic group having 9 to 23 carbon atoms
  • R 5 to R 7 each independently represents a hydrogen atom or a carbon atom having a branched chain having 1 or 2 carbon atoms.
  • R 8 represents an aliphatic group having 9 to 23 carbon atoms
  • R 9 to R 12 each independently represents a hydrogen atom, or a carbon atom number that can have a branched chain having 1 or 2 carbon atoms.
  • n represents an -X group, n represents a number from 1 to 4, X is an amino group, a guanidino group, -CONH 2 group, or a nitrogen atom and 1 to 3
  • X is an amino group, a guanidino group, -CONH 2 group, or a nitrogen atom and 1 to 3
  • This represents a 5-membered ring or 6-membered ring which may have one or a condensed heterocyclic ring composed of a 5-membered ring and a 6-membered ring.
  • the present invention further relates to the stick-like substrate according to the first aspect, further comprising 1,2-alkanediol or 1,3-alkanediol.
  • the present invention relates to the stick-shaped substrate according to the third aspect, in which the alginic acid derivative is an alginate polyhydric alcohol ester.
  • the thickener is included in a proportion of 0.1 to 1.0% by mass based on the total mass of the stick-like substrate.
  • the present invention relates to the stick-like substrate described in one.
  • the present invention relates to the stick-like substrate according to any one of the third to fifth aspects, wherein the betaine compound is sulfate-type betaine.
  • the monohydric alcohol is one or more compounds selected from the group consisting of myristyl alcohol, cetanol, stearyl alcohol, and behenyl alcohol, according to any one of the first to sixth aspects.
  • This relates to a stick-like substrate.
  • any one of the first aspect to the seventh aspect, wherein the lipid peptide type compound is contained at a ratio of 0.1 to 2% by mass based on the total mass of the stick-like substrate. It relates to the stick-like base material described in one.
  • the stick-shaped base material which can have the breaking strength calculated
  • the use of a specific surfactant and a specific thickener reduces the amount of lipid peptide type compound based on the total mass of the substrate. Even when the content is less than or equal to mass%, it may have a breaking strength required for a stick-like substrate.
  • the lipid peptide compound contained in the stick-like substrate of the present invention is a very safe artificial low molecular weight compound composed only of lipid and peptide.
  • the compound can form an aqueous gel without using a crosslinking agent or the like required for forming a synthetic polymer type gel that has been proposed in the past. The problem of remaining unreacted materials such as cross-linking agents does not occur.
  • various components contained as additives in the stick-shaped substrate of the present invention are general-purpose additives as additives for foods, cosmetics, and pharmaceuticals.
  • the stick-shaped substrate of the present invention has high biological safety, and is particularly useful in the above applications from the viewpoint of safety required for pharmaceuticals and cosmetics.
  • the stick-like base material of the present invention is expected to be a base material having a good refreshing feeling when applied to human skin, etc. It is very useful as a stick-like base material for cosmetics and cosmetics.
  • the present invention relates to one or more surfactants selected from the group consisting of betaine compounds and ethylene glycol alkyl ethers, water, compounds represented by the following formulas (1) to (3), or pharmaceuticals thereof.
  • a lipid peptide-type compound comprising at least one of the salts that can be used in the above, 1,2-alkanediol or 1,3-alkanediol, and at least one saturated or unsaturated monovalent group having 8 to 30 carbon atoms.
  • the present invention relates to a stick-like substrate comprising alcohol, one or more thickeners selected from the group consisting of alginic acid derivatives and carrageenan, and optionally other additives.
  • each component will be described.
  • the lipid peptide type compound used in the stick-shaped substrate of the present invention is a compound (lipid peptide) represented by the following formulas (1) to (3) or a pharmaceutically usable salt thereof (hydrophobic site).
  • a low molecular compound having a lipid part and a peptide part which is a hydrophilic part) can be used.
  • R 1 represents an aliphatic group having 9 to 23 carbon atoms, and preferably R 1 is a straight chain having 11 to 23 carbon atoms which may have 0 to 2 unsaturated bonds.
  • An aliphatic group is desirable.
  • Specific examples of the lipid moiety (acyl group) composed of a carbonyl group adjacent to R 1 include lauroyl group, dodecylcarbonyl group, myristoyl group, tetradecylcarbonyl group, palmitoyl group, margaroyl group, oleoyl group, and elideoyl group.
  • Examples include lauroyl group, myristoyl group, palmitoyl group, margaroyl group, stearoyl group, oleoyl group, elidoyl group, and behenoyl group.
  • R 2 contained in the peptide part represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms.
  • the alkyl group having 1 to 4 carbon atoms that may have a branched chain having 1 or 2 carbon atoms is a branched chain having 1 to 4 carbon atoms in the main chain and 1 or 2 carbon atoms.
  • Means an alkyl group which may have, and specific examples thereof include methyl group, ethyl group, n-propyl group, i-propyl group, n-butyl group, i-butyl group, sec-butyl group or tert-butyl group Etc.
  • R 2 is preferably a hydrogen atom or an alkyl group having 1 to 3 carbon atoms which may have a branched chain having 1 carbon atom, and more preferably a hydrogen atom.
  • the alkyl group having 1 to 3 carbon atoms which can have a branched chain having 1 carbon atom is an alkyl group having 1 to 3 carbon atoms in the main chain and having a branched chain having 1 carbon atom.
  • a methyl group an ethyl group, an n-propyl group, an i-propyl group, an i-butyl group, or a sec-butyl group, preferably a methyl group, an i-propyl group, An i-butyl group or a sec-butyl group.
  • R 3 represents a — (CH 2 ) n—X group.
  • n represents a number of 1 to 4
  • X is an amino group, a guanidino group, a —CONH 2 group, or a 5-membered cyclic group having 1 to 3 nitrogen atoms.
  • X is preferably an amino group, guanidino group, carbamoyl group (—CONH 2 group), pyrrole group, imidazole group, pyrazole group or indole group, and more Preferably it is an imidazole group.
  • the - in (CH 2) n-X group, n is preferably 1 or 2, more preferably 1. Therefore, the — (CH 2 ) n- group is preferably an aminomethyl group, 2-aminoethyl group, 3-aminopropyl group, 4-aminobutyl group, carbamoylmethyl group, 2-carbamoylethyl group, 3-carbamoyl group.
  • a lipid peptide particularly suitable as a lipid peptide type compound is a compound formed from the following lipid part and peptide part (amino acid assembly part).
  • amino acids alanine (Ala), asparagine (Asn), glutamine (Gln), glycine (Gly), histidine (His), isorosine (Ile), leucine (Leu), lysine (Lys), tryptophan (Trp) ), Valine (Val).
  • Lauroyl-Gly-His Lauroyl-Gly-Gln, Lauroyl-Gly-Asn, Lauroyl-Gly-Trp, Lauroyl-Gly-Lys, Lauroyl-Ala-His, Lauroyl-Ala-Gln, Lauroyl-Ala-Asn, Lauroyl -Ala-Trp, Lauroyl-Ala-Lys; Myristoyl-Gly-His, Myristoyl-Gly-Gln, Myristoyl-Gly-Asn, Myristoyl-Gly-Trp, Myristoyl-Gly-Lys, Myristoyl-Ala-His, Myristoyl-Ala -Gln, Myristoyl-Ala-Asn, Myristoyl-Ala-Trp, Myristoyl-Ala-Lys; Palmitoyl-Gly-His, Palmitoyl-Gly-Gln, Palmi
  • lauroyl-Gly-His lauroyl-Ala-His-myristoyl-Gly-His, myristoyl-Ala-His; palmitoyl-Gly-His, palmitoyl-Ala-His; stearoyl-Gly-His, stearoyl-Ala -His.
  • R 4 represents an aliphatic group having 9 to 23 carbon atoms, and preferred specific examples include the same groups as defined for R 1 above.
  • R 5 to R 7 are each independently a hydrogen atom, an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms, or — ( CH 2 ) nX group, and preferably at least one of R 5 to R 7 represents a — (CH 2 ) nX group.
  • n a number of 1 to 4
  • X represents an amino group, a guanidino group, a —CONH 2 group, or a 5-membered cyclic group or a 6-membered cyclic group that may have 1 to 3 nitrogen atoms, or a 5-membered ring And a condensed heterocyclic group composed of a 6-membered ring.
  • R 5 to R 7 include the same groups as defined for R 2 and R 3 above.
  • a preferable lipid peptide is a compound formed from the following lipid part and peptide part (amino acid assembly part).
  • Lauroyl-Gly-Gly-His Lauroyl-Gly-Gly-Gln, Lauroyl-Gly-Gly-Asn, Lauroyl-Gly-Gly-Trp, Lauroyl-Gly-Gly-Lys, Lauroyl-Gly-Ala-His, Lauroyl-His Gly-Ala-Gln, Lauroyl-Gly-Ala-Asn, Lauroyl-Gly-Ala-Trp, Lauroyl-Gly-Ala-Lys, Lauroyl-Ala-Gly-His, Lauroyl-Ala-Gly-Gln, Lauroyl-Ala- Gly-Asn, Lauroyl-Ala-Gly-Trp, Lauroyl-Ala-Gly-Lys, Lauroyl-Ala-Gly-Hi
  • lauroyl-Gly-Gly-His myristoyl-Gly-Gly-His, palmitoyl-Gly-Gly-His, palmitoyl-Gly-His-Gly, palmitoyl-His-Gly-Gly, stearoyl -Gly-Gly-His.
  • R 8 represents an aliphatic group having 9 to 23 carbon atoms, and preferred specific examples include the same groups as defined for R 1 above.
  • R 9 to R 12 are each independently a hydrogen atom, an alkyl group having 1 to 4 carbon atoms which may have a branched chain having 1 or 2 carbon atoms, or — ( CH 2 ) nX group, and preferably at least one of R 9 to R 12 represents a — (CH 2 ) nX group.
  • n a number of 1 to 4
  • X represents an amino group, a guanidino group, a —CONH 2 group, or a 5-membered cyclic group or a 6-membered cyclic group that may have 1 to 3 nitrogen atoms, or a 5-membered ring And a condensed heterocyclic group composed of a 6-membered ring.
  • R 9 to R 12 include the same groups as defined for R 2 and R 3 above.
  • particularly preferred lipid peptides include lauroyl-Gly-Gly-Gly-His, myristoyl-Gly-Gly-Gly-His, palmitoyl. -Gly-Gly-Gly-His, Palmitoyl-Gly-Gly-His-Gly, Palmitoyl-Gly-His-Gly-Gly, Palmitoyl-His-Gly-Gly-Gly, Stearoyl-Gly-Gly-Gly-His, etc. Can be mentioned.
  • the amount of the lipid peptide type compound is, for example, 0.1 to 2% by mass, preferably 0.3 to 1.5% by mass, and more preferably based on the total mass of the stick-like substrate to be obtained. Is 0.5 to 1.0 mass%.
  • the lipid peptide type compound used in the present invention comprises at least one of the compounds represented by the above formulas (1) to (3) (lipid peptide) or a pharmaceutically usable salt thereof, and is hydrogelated. These compounds can be used alone or in combination of two or more as an agent.
  • the surfactant used in the stick-shaped substrate of the present invention includes a compound having a hydrophilic part and a hydrophobic part in the molecule, and the hydrophilic part having a betaine structure (hereinafter also referred to as a betaine compound) and ethylene glycol.
  • a betaine compound hereinafter also referred to as a betaine compound
  • An alkyl ether is mentioned.
  • betaine compounds as described above include N-alkyl-N, N-dimethylamino acid betaines such as lauryldimethylaminoacetic acid betaine (lauryl betaine); fatty acid amide alkyl-N such as cocamidopropyl betaine and lauramidopropyl betaine.
  • N-dimethylamino acid betaine N-dimethylamino acid betaine; imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkylsulfobetaines such as laurylhydroxysulfobetaine and alkyldimethyltaurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate; alkyldimethylaminoethanol Known betaine compounds such as phosphate-type betaines such as phosphate esters can be used as amphoteric surfactants. As the betaine compound, sulfate-type betaine is preferable.
  • betaine compounds include phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, phosphatidylglycerol, diphosphatidylglycerol (cardiolipin), phosphatidic acid and other glycerophospholipids; lysophosphatidylcholine (lysolecithin), lysophosphatidylethanolamine, Examples thereof include lysoglycerophospholipids such as serine, lysophosphatidylinositol, lysophosphatidylglycerol, and lysophosphatidic acid; sphingophospholipids such as sphingomyelin; and hydrogenated products thereof.
  • phospholipids may be derived from animals and plants such as soybeans and egg yolks, or may be synthesized by a chemical or enzymatic method.
  • betaine compounds preferably lauryldimethylaminoacetic acid betaine, lauric acid amidopropyl betaine, lauryl hydroxysulfobetaine, stearyl betaine, lysophosphatidylcholine (lysolecithin), lysophosphatidylethanolamine, lysophosphatidylserine, lysophosphatidylinositol, lyso Examples include phosphatidylglycerol and lysophosphatidic acid, and more preferably lauryl hydroxysulfobetaine.
  • ethylene glycol alkyl ether examples include polyoxyethylene alkyl ether, polyoxyethylene lauryl ether, polyoxyethylene palmitoyl ether, and polyoxyethylene stearyl ether. Polyoxyethylene lauryl ether is preferable. Also, commercially available ethylene glycol alkyl ethers can be used. Examples of such products include Emulgen 102KG, Emargen 103, and Emulgen 104P in Kao's Emulgen (registered trademark) series and Emanon (registered trademark) series.
  • Emulgen 103 More preferably, Kao's Emulgen 103, Emulgen 104P, Emulgen 105, Emulgen 106, Emulgen 108, Emulgen 109P, Emulgen 210P, Emulgen 306P, Emulgen 320P, Emulgen 404, Emulgen 408, Emulgen 409PV, Emulgen 420, Emulgen 705 , Emulgen 707, Emulgen 709, Emulgen 1108, Emulgen 2020G-HA, Emanon 1112, Emanon 4110.
  • Emulgen 104P More preferably, Kao's Emulgen 104P, Emulgen 105, Emulgen 106, Emulgen 108, Emulgen 210P, Emulgen 306P, Emulgen 408, Emulgen 409PV, Emulgen 705, Emulgen 707, Emulgen 709, Emulgen 1108, Emulgen 2020G-HA, Emanon 1112, Emanon 4110.
  • it can be appropriately selected from the NIKKOL (registered trademark) series of Nikko Chemicals.
  • NIKKOL BT-5, NIKKOL BT-7, NIKKOL BT-9, NIKKOL BT-12, NIKKOL BL-2, NIKKOL BL-4.2, NIKKOL BL-9EX, etc. most preferably NIKOL BL-9EX 9EX.
  • HLB Hydrophile-Lipophile Balance
  • the compounding amount of the surfactant is, for example, 0.1 to 20% by mass, preferably 0.1 to 10% by mass with respect to the total mass of the stick-like substrate to be obtained.
  • ethylene glycol alkyl ether for example, 0.1 to 3% by mass is preferable with respect to the total mass of the obtained stick-like substrate, and when a betaine compound is used, it is obtained.
  • 0.5 to 10% by mass is preferable with respect to the total mass of the stick-shaped substrate.
  • the surfactant used in the present invention is at least one of the above-mentioned surfactant group, and these surfactants can be used alone or in combination of two or more.
  • the 1,2-alkanediol or 1,3-alkanediol used in the stick-like substrate of the present invention has a function of promoting the solubility of the lipid peptide type compound.
  • 1,3-alkanediol is preferred.
  • Specific examples of the 1,2-alkanediol include 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol, and the like. Preferred are 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol.
  • 1,2-pentanediol or 1,2-hexanediol More preferred is 1,2-pentanediol or 1,2-hexanediol.
  • the 1,2-alkanediol used in the present invention is at least one of the aforementioned 1,2-alkanediol group.
  • Specific examples of the 1,3-alkanediol include 1,3-propanediol, 2-methyl-1,3-propanediol, 1,3-butanediol, 3-methyl-1,3-butanediol, , 3-pentanediol, 1,3-hexanediol, 2-ethyl-1,3-hexanediol, 2-ethyl-1,3-octanediol, 1,3-decanediol, and the like.
  • 1,3-pentanediol 1,3-hexanediol, 2-ethyl-1,3-hexanediol, and 2-ethyl-1,3-octanediol. More preferred are 2-ethyl-1,3-hexanediol and 2-ethyl-1,3-octanediol.
  • the 1,3-alkanediol used in the present invention is at least one of the aforementioned 1,3-alkanediol group.
  • 1,3-alkanediol for example, 1,3-butanediol is preferable.
  • These 1,2-alkanediols or 1,3-alkanediols can be used alone or in combination of two or more.
  • the blending amount of 1,2-alkanediol or 1,3-alkanediol is, for example, 0.5 to 20% by mass, preferably 1 to 1% by mass with respect to the total mass of the obtained stick-like substrate. It is 10% by mass, more preferably 2 to 8% by mass.
  • At least one saturated or unsaturated monohydric alcohol having 8 to 30 carbon atoms By adding at least one saturated or unsaturated monohydric alcohol having 8 to 30 carbon atoms to the stick-shaped substrate of the present invention, the stability of the substrate is improved, specifically the surface of the substrate. The oil release phenomenon called “sweat” can be suppressed.
  • at least one saturated or unsaturated monohydric alcohol having 8 to 30 carbon atoms is also simply referred to as “higher alcohol”. These higher alcohols are commercially available or synthesized many raw materials including derivatives, but in the stick-like base material of the present invention, preferably at least one kind of alkyl group having 8 to 30 carbon atoms.
  • Saturated or unsaturated monohydric alcohols can be used, more preferably 12 to 22 saturated monohydric alcohols, among which myristyl alcohol (14 carbon atoms), cetanol (16 carbon atoms). Stearyl alcohol (18 carbon atoms) and behenyl alcohol (22 carbon atoms) are particularly preferred because of their high versatility and high “sweat” -suppressing effect.
  • the compounding amount of the higher alcohol is, for example, 0.001 to 1% by mass, preferably 0.01 to 0.5% by mass, and more preferably 0% with respect to the total mass of the stick-like substrate to be obtained. 0.03 to 0.3% by mass.
  • the said higher alcohol used in this invention is at least 1 type of the above-mentioned higher alcohol group, These can be used individually by 1 type or in combination of 2 or more types.
  • Examples of the thickener used in the stick-shaped substrate of the present invention include alginic acid derivatives and carrageenan.
  • Examples of the alginic acid derivative used in the stick-shaped substrate of the present invention include alginic acid, alginic acid salts (sodium salt, potassium salt, calcium salt, etc.), alginic acid ester, and the like.
  • Alcohol esters are preferred.
  • Examples of the alginic acid polyhydric alcohol ester include ethylene glycol alginate and propylene glycol alginate, and propylene glycol alginate is preferable.
  • the blending amount of the thickener used is, for example, 0.3 to 1.0% by mass, preferably 0.3 to 0.7% by mass, based on the total mass of the stick-like substrate to be obtained. It is.
  • the thickener used in this invention is at least 1 sort (s) of the thickener selected from the above, These thickeners can be used individually by 1 type or in combination of 2 or more types.
  • the stick-like substrate of the present invention can also contain fatty acids, oily bases, pigments, organic acids, polyhydric alcohols, and other additives. Each component will be described below.
  • the fatty acid that can be used in the stick-shaped substrate of the present invention is preferably at least one selected from the group consisting of saturated fatty acids having 10 to 20 carbon atoms and unsaturated fatty acids and salts of these fatty acids.
  • saturated fatty acids having 10 to 20 carbon atoms and unsaturated fatty acids and salts of these fatty acids.
  • examples include capric acid, undecanoic acid, lauric acid, tridecanoic acid, myristic acid, pentadecanoic acid, palmitic acid, margaric acid, and stearic acid. More preferably, capric acid, lauric acid, myristic acid, palmitic acid, and stearic acid are mentioned, and stearic acid is particularly preferable.
  • the amount of the fatty acid used is, for example, 0.1 to 2.0% by mass, preferably 0.2 to 1.0% by mass, based on the total mass of the stick-like substrate to be obtained. is there.
  • the fatty acid which can be used in this invention is at least 1 sort (s) selected from the said fatty acid group, These fatty acids can be used individually by 1 type or in combination of 2 or more types.
  • oily base that can be used in the stick-like substrate of the present invention is not particularly limited, and examples thereof include the following oily bases: oleyl alcohol, jojoba alcohol, chimyl alcohol, seraalkyl alcohol, batyl alcohol, Higher (polyhydric) alcohols such as hexyldecanol, isostearyl alcohol, 2-octyldodecanol, dimer diol; aralkyl alcohols such as benzyl alcohol and derivatives thereof; isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, palmi Tooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexadecanoic acid, antiisohenicosanoic acid, long-chain branched fatty acid, dimer acid,
  • Acyl sarcosine alkyl ester Acyl sarcosine alkyl ester, cholesteryl 12-hydroxystearate, macadamia nut oil fatty acid cholesteryl, macadamia nut oil fatty acid phytosteryl, phytosteryl isostearate, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long chain branched fatty acid cholesteryl, long chain ⁇ -hydroxy fatty acid cholesteryl, etc.
  • the blending amount when the oily base is used is, for example, 1 to 50% by mass, preferably 5 to 50% by mass, more preferably 5 to 5% by mass with respect to the total mass of the stick-like substrate to be obtained. It is 20% by mass, particularly preferably 10 to 20% by mass.
  • the oily base that can be used in the present invention is at least one of the above-mentioned oily base group, and these oily bases may be used alone or in combination of two or more.
  • the stick-like substrate of the present invention may further contain a pigment.
  • the pigment that can be blended is not particularly limited.
  • inorganic white pigments such as titanium dioxide and zinc oxide
  • inorganic red pigments such as red iron oxide (bengala) and iron titanate
  • Inorganic yellow pigments such as yellow iron oxide and loess
  • inorganic black pigments such as black iron oxide and low-order titanium oxide
  • inorganic purple pigments such as mango violet and cobalt violet
  • Inorganic green pigments such as chromium and cobalt titanate
  • inorganic blue pigments such as ultramarine and bitumen
  • titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, fish scale Pearl pigments such as foil; talc, sericite, mica, kaolin, calcium carbonate, magnesium carbonate, silicic anhydr
  • the blending amount is, for example, 1 to 50% by mass, preferably 5 to 50% by mass, and more preferably 6 to 20%, based on the total mass of the stick-like substrate to be obtained. % By mass, particularly preferably 10 to 20% by mass.
  • the said pigment used in this invention is at least 1 type of the above-mentioned pigment group, These pigments can be used individually by 1 type or in combination of 2 or more types.
  • the stick-like substrate of the present invention may further contain an organic acid.
  • the organic acid include ascorbic acid, citric acid, lactic acid, glycolic acid, succinic acid, acetic acid, malic acid, tartaric acid, and fumaric acid.
  • ascorbic acid, citric acid, and lactic acid are preferable, and ascorbic acid and citric acid are particularly preferable.
  • the compounding quantity in the case of using an organic acid is 1-20 mass% with respect to the total mass of the stick-shaped base material obtained, Preferably it is 1-10 mass%.
  • the stick-like substrate of the present invention may further contain a polyhydric alcohol.
  • the polyhydric alcohol is a polyhydric alcohol different from the 1,2-alkanediol or 1,3-alkanediol listed above, and specific examples thereof include glycerin, propylene glycol, and polyethylene glycol.
  • the temporal stability of the stick-like substrate can be improved.
  • polyethylene glycol having an average molecular weight of 1,000 to 4,000 can be preferably used.
  • the blending amount can be, for example, 1 to 80% by mass, preferably 1 to 60% by mass, based on the total mass of the stick-like substrate to be obtained.
  • the stick-like substrate of the present invention can be blended with additives that can generally be used as cosmetic additives, quasi-drug additives, and pharmaceutical additives as necessary.
  • additives such as physiologically active substances and functional substances that are blended in cosmetics, quasi-drugs, or pharmaceutical external preparations for skin include moisturizers, feel-improving agents, surfactants other than the above, solvents, and antioxidants.
  • Agent reducing agent, oxidizing agent, preservative, antibacterial agent, bactericidal agent, chelating agent, pH adjuster, acid, alkali, powder, inorganic salt, UV absorber, whitening agent, vitamins and derivatives thereof, for hair growth Drug, Blood circulation promoter, Stimulant, Hormones, Anti-wrinkle agent, Anti-aging agent, Tightening agent, Cool sensation agent, Warm sensation agent, Wound healing promoter, Stimulation mitigation agent, Analgesic agent, Cell activator, Plant / Animal ⁇ Microbial extract, antipruritic agent, exfoliating / dissolving agent, antiperspirant, refreshing agent, astringent, enzyme, nucleic acid, fragrance, pigment, colorant, dye, anti-inflammatory agent, anti-inflammatory agent, anti-asthma, anti-chronic obstructive Examples include pulmonary diseases, antiallergies, immune regulators, antiinfectives and antifungals It is.
  • the blending amount of these other additives may vary depending on the type of
  • moisturizers / feel improvers include glycerin, trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol / propylene glycol copolymer and the like polyols and Polymers; glycol alkyl ethers such as diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether; (eicosane diacid / tetradecanedioic acid) polyglyceryl-10, tetradecane Water-soluble esters such as polyglyceryl-10; sorbitol, xylitol, erythritol, man Sugar alcohols such as tol and maltitol; glucose, fructose
  • the surfactant include an anionic surfactant, a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and a polymer surfactant.
  • preferable surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfate esters such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; Polyoxyethylene alkyl sulfates such as sodium laureth sulfate and triethanolamine laureth sulfate; cocoyl methyl taurine sodium, cocoyl methyl taurine potassium, lauroyl methyl taurine sodium, myristoyl methyl taurine sodium, lauroyl methyl alanine sodium, lauroyl sarcosine sodium, lauroyl sarcosine tri Acyl N-methyl amino acid salts such as ethanolamine and sodium methylalanine sodium, la
  • Polyoxyethylene alkyl ethers with various polyoxyethylene addition numbers such as silethylene behenyl ethers), isosteares (polyoxyethylene isostearyl ether) s, octyldecesses (polyoxyethylene octyldodecyl ethers); Ether: Polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearic acid diester Castor oil and hardened castor oil derivatives such as polyoxyethylene hydrogenated castor oil maleic acid; polyoxyethylene phytosterol; polyoxyethylene cholesterol Polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene / polyoxypropylene cetyl ether, polyoxyethylene / polyoxypropylene 2-decyltetradecyl ether, polyoxy
  • Polyglyceryl ethers polyoxyethylene alkylamines; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponins and sophorolipids; polyoxyethylene fatty acid amides; Palm oil fatty acid monoethanolamide (cocamide MEA), palm oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (Lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), palm oil fatty acid methylethanolamide ( Fatty acid alkanolamides such as cocamidomethyl MEA); alkyldimethylamine oxides such as lauramine oxide, cocamamine oxide, stearamine oxide, and behenamine oxide; alkylethoxydimethylamine oxide; polyoxyethylene al
  • Nonionic surfactants of silicone, etc .; cationic surfactants include alkyltrimethylammonium chlorides such as behentrimonium chloride, steartrimonium chloride, cetrimonium chloride, lauryltrimonium chloride; stearyltrimonium bromide, etc.
  • Alkyltrimethylammonium bromides dialkyldimethylammonium chlorides such as distearyldimonium chloride and dicocodimonium chloride; fatty acid amidoamines and salts thereof such as stearamidepropyldimethylamine and stearamideethyldiethylamine; alkyl ethers such as stearoxypropyldimethylamine Amines and salts or quaternary salts thereof; ethyl sulfate long chain branched fatty acid (12-31) aminopropylethyldimethylammonium Fatty acid amide type quaternary ammonium salts such as lanolin fatty acid aminopropylethyldimethylammonium; polyoxyethylene alkylamines and salts or quaternary salts thereof; alkylamine salts; fatty acid amidoguanidinium salts; alkyl etheraminemonium salts; Benzalkonium salts; benzethonium salts
  • Silicone-based cationic surfactants such as amino-modified silicone, cation-modified silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone
  • amphoteric surfactant etc N-alkyl-N, N-dimethylamino acid betaines such as lauryl betaine (lauryldimethylaminoacetic acid betaine); fatty acid amide alkyl-N, N-dimethylamino acid betaines such as cocamidopropyl betaine and lauramidopropyl betaine; sodium cocoamphoacetate; Imidazoline-type betaines such as sodium lauroamphoacetate; alkylsulfobetaines such as alkyldimethyltaurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate; phosphate-type betaines such as alkyldimethylaminoethanol phosphate; phosphati
  • Solvents include lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol and isobutyl alcohol; glycols such as propylene glycol, diethylene glycol, dipropylene glycol and isopentyl diol; diethylene glycol monoethyl ether (ethoxydiglycol) , Glycol ethers such as ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether; ethylene glycol monoethyl ether Acetate, diethylene glycol Glycol ether esters such as ethyl ether acetate and propylene glycol monoethyl ether acetate; glycol esters such as diethoxyethyl succinate and ethylene
  • Antioxidants include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or derivatives thereof; erythorbic acid and derivatives thereof; Preferred are sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride As mentioned.
  • Preferred examples of the reducing agent include thioglycolic acid, cysteine, cysteamine and the like.
  • Preferred examples of the oxidizing agent include hydrogen peroxide water, ammonium persulfate, sodium bromate, percarbonate, and the like.
  • preservatives, antibacterial agents, and bactericides include hydroxybenzoic acid such as methylparaben, ethylparaben, propylparaben, and butylparaben, and salts or esters thereof; salicylic acid; sodium benzoate; phenoxyethanol; methylchloroisothiazolinone, methylisothiazo Isothiazolinone derivatives such as linone; imidazolinium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzalkonium chloride, chloride Benzethonium, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, hinokitiol; phenol, isopropylphenol, cresol, Mall
  • chelating agents include edetate (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; Phosphonic acid and its sodium salt; polyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine, gluconic acid, Ascorbic acid, succinic acid and tartaric acid are preferred.
  • edetate ethylenediaminetetraacetate
  • HEDTA3Na EDTA3Na
  • EDTA4Na hydroxyethylethylenediaminetriacetate
  • pentetate diethylenetriaminepentaacetate
  • phytic acid
  • pH adjusters / acids / alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, potassium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid , Monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine Sodium hydroxide, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate are preferable.
  • powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, saucite, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, and silicic acid.
  • Inorganic salts include sodium chloride-containing salts such as salt, common salt, rock salt, sea salt, natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, Aluminum sulfate / potassium sulfate (alum), aluminum sulfate / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na, 2Na and 3Na phosphates, phosphoric acid Potassium, calcium phosphates and magnesium phosphates are preferred.
  • sodium chloride-containing salts such as salt, common salt, rock salt, sea salt, natural salt
  • potassium chloride aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chlor
  • ultraviolet absorbers examples include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, and N, N-dimethylparaaminobenzoic acid ethyl ester.
  • Benzoic acid ultraviolet absorbers such as esters, N, N-dimethylparaaminobenzoic acid butyl ester, N, N-dimethylparaaminobenzoic acid methyl ester; Anthranilic acid ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; Salicylic acid And salicylic acid systems such as sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate External line absorbent: octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl c
  • UV absorbers 3- (4′-methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2′-hydroxy- 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole; 2- (2′-hydroxy-5′-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyl triazone; urocanic acid such as urocanic acid and ethyl urocanate Derivatives; 2- (2′-hydroxy-5′-methylphenyl) benzotriazole Hydantoin derivatives such as 1- (3,4-dimethoxypheny
  • whitening agents include hydroquinone glycosides such as arbutin and ⁇ -arbutin and their esters; ascorbic acid phosphates such as ascorbic acid, sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate, ascorbic acid Ascorbic acid fatty acid esters such as tetraisopalmitic acid ester, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucosides such as ascorbic acid-2-glucoside and fatty acid esters thereof, ascorbic acid sulfate ester, tocopheryl ascorbyl phosphate Ascorbic acid derivatives such as kojic acid, ellagic acid, tranexamic acid and its derivatives, ferulic acid and its derivatives, placenta extract, glutathione, oryzanol, butylreso Shinoru, oil-soluble Kamomiraekisu, oil-soluble licorice extract,
  • Vitamins and their derivatives include vitamin A such as retinol, retinol acetate, retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, Flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid such as nicotinic acid amide / benzyl nicotinate, vitamin B group such as choline; vitamin C such as ascorbic acid and its sodium salt; vitamin D; ⁇ , Vitamin E such as ⁇ , ⁇ , and ⁇ -tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphates such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt, Ascorbic acid fatty acid esters
  • Plant extracts and tinctures such as assembly extract, red pepper tincture, ginger tincture, ginger extract, cantalis tincture; capsaicin, nonylic acid vanillylamide, gingeron, ictamol, tannic acid Borneol, cyclandrate, cinnarizine, trazoline, acetylcholine, verapamil, cephalanthin, ⁇ -oryzanol, vitamin E and derivatives such as nicotinic acid tocopherol / acetic acid tocopherol, nicotinic acid and nicotinic acid amide / nicotinic acid benzyl ester / inositol hexanicotinate Derivatives of nicotine alcohol, allantoin, photosensitive element 301, photosensitive element 401, capronium chloride, pentadecanoic acid monoglyceride, flavonol derivative, stigma Terol or stigmastanol and glycosides thereof, and the
  • hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like.
  • Other remedies such as anti-wrinkle agents, anti-aging agents, squeeze agents, cooling sensations, warming sensation agents, wound healing promoters, irritation relievers, analgesics, cell activators include retinols, retinoic acids, retinoin Acid tocopheryl; derivatives such as lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and glycosides / esterified products thereof, ⁇ - or such as hydroxycapric acid, long chain ⁇ -hydroxy fatty acid, long chain ⁇ -hydroxy fatty acid cholesteryl ⁇ -hydroxy acids and derivatives thereof; ⁇ -aminobutyric acid, ⁇ -amino- ⁇ -hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosines; caffeine, xant
  • Antioxidant / active oxygen scavengers include catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamin, protoanthocyanidin, chlorogenic acid, apple polyphenol; rutin and glycosides, etc.
  • hesperidin and glycosides Derivatives of hesperidin and glycosides; lignan glycosides; licorice extract-related substances such as grabrizine, glabrene, liquiritin, and isoliquiritin; lactoferrin; shogaol, gingerol; and fragrance substances such as menthol and cedrol; And insecticides such as diethyl toluamide; complexes of physiologically active substances and cyclodextrins are preferred.
  • Plant / animal / microbe extracts include iris extract, ashitaba extract, asunalo extract, asparagus extract, avocado extract, achacha extract, almond extract,retea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo biloba extract , Carrot extract, fennel extract, turmeric extract, oolong tea extract, walrus extract, ages extract, echinacea leaf extract, enmeo extract, peony extract, duckweed extract, lauren extract, barley extract, ginseng extract, hypericum extract, licorice extract, Onionis extract, Dutch mustard extract, orange extract, dried seawater, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, water Denatured silk, cocoon extract, chamomile extract, oil-soluble chamomile extract, carrot extract, kawarayomigi extract, oat extract, calcade extract, licorice extract, oil-soluble
  • antipruritic agents examples include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor, and the like.
  • exfoliating / dissolving agent examples include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine and the like.
  • antiperspirants examples include chlorohydroxyaluminum, aluminum chloride, zinc oxide, zinc paraphenol sulfonate, and the like.
  • Examples of the refreshing agent include menthol and methyl salicylate.
  • astringents include citric acid, tartaric acid, lactic acid, aluminum sulfate / potassium, and tannic acid.
  • Enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, and the like.
  • Preferred nucleic acids include ribonucleic acid and its salts, deoxyribonucleic acid and its salts, and adenosine triphosphate disodium.
  • Orange No. 201 Orange No. 203, Orange No. 204, Orange No. 205, Orange No. 206, Orange No. 207, Orange No. 401, Orange No. 402, Orange No. 403, Yellow No. 201, Yellow No. 202-1 Yellow 202-2, Yellow 203, Yellow 204, Yellow 205, Yellow 4, Yellow 401, Yellow 402, Yellow 403-1, Yellow 404, Yellow 405, Yellow 406, Yellow Legal pigments such as No. 407 and Yellow No.
  • Anti-inflammatory / anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, ketoprofen, ibuprofen, diclofenac, loxoprofen, celecoxib, infliximab, etanercept, zinc oxide, hydroacetic acid, zinc acetate, Preferred examples include prednisone, diphedramine hydrochloride, chlorpheniramine maleate; and plant extracts such as peach leaf extract and persimmon leaf extract.
  • Anti-asthma, anti-chronic obstructive pulmonary disease, anti-allergy, immunomodulators include aminophylline, theophylline, steroids (fluticasone, beclomethasone, etc.), leukotriene antagonists, thromboxane inhibitors, intal, ⁇ 2-stimulant (Formoterol, salmeterol, albuterol, tulobuterol, clenbuterol, epinephrine, etc.), tiotropium, ipratropium, dextromethorphan, dimemorphan, bromhexine, tranilast, ketotifen, azelastine, cetirizine, chlorpheniramine, polyquitolsine, Preferred examples include cytokine regulators, interferons, omalizumab, and protein / antibody preparations.
  • Preferred examples of the anti-infective and antifungal agents include oseltamivir, zanamivir, and itraconazole.
  • cosmetic raw material standards cosmetic ingredient-specific combination ingredient standards, Japan Cosmetic Industry Association ingredient display name list, INCI dictionary (The International Cosmetic Ingredients and Handbooks), quasi-drug ingredients standards, Japanese pharmacopoeia, pharmaceutical additive standards Ingredients listed in the Food Addendum, etc., and the international patent classification IPC described in Japan and other foreign patent gazettes and patent publications (including publications and republications) belonging to the A61K7 and A61K8 classifications It is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., in known combinations, blending ratios and blending amounts.
  • the stick-like substrate of the present invention comprises a lipid peptide compound comprising at least one of the compounds represented by the formulas (1) to (3) or a pharmaceutically usable salt thereof, a surfactant and water, 1,2-alkanediol or 1,3-alkanediol, higher alcohol, thickener and, if necessary, an oily base, pigment, and other additives, mixed and stirred with heating, then allowed to stand It can be manufactured by cooling.
  • the stick-shaped substrate of the present invention is produced by the following process as an example. a) a step of blending the above-mentioned lipid peptide compound, a surfactant and water, and preparing a solution or dispersion by heating; b) adding the solution or dispersion to water and heating at a temperature of room temperature to less than 100 ° C .; c) The process which cools with stirring until it becomes temperature lower than the temperature in the said heating process, and is left still standing to cool, and forms a gel-like solid substance (stick-shaped base material).
  • 1,2-alkanediol or 1,3-alkanediol, oily base, higher alcohol, thickener, pigment and other additives are added in the step of preparing the solution or dispersion in step a).
  • it may be added in advance to the water to which the solution or dispersion is added in step b).
  • water is 20 mass% or more and less than 99 mass% with respect to the total mass of the obtained stick-shaped base material.
  • water is 30 to 80 mass% with respect to the total mass of the obtained solution or dispersion.
  • the heating temperature in the step a) and the step b) is preferably 50 ° C. to 90 ° C., more preferably 60 ° C. to 90 ° C., for example 80 ° C., and stirring is preferably performed while heating.
  • the time of heating and stirring in each step at this time varies depending on the type of lipid peptide compound used, the surfactant and other components, and the blending amount thereof, but can usually be dissolved and dispersed in about 5 to 50 minutes. .
  • cooling is performed with stirring until the liquid temperature is lower than the temperature in step b) (step c).
  • the cooling temperature is, for example, room temperature to 80 ° C., room temperature to 60 ° C., or room temperature to 40 ° C.
  • the stick-shaped base material of this invention can also be manufactured by adding suitably another compounding component to this premix.
  • the following is mentioned as a manufacturing method of the stick-shaped base material which passed through the premix.
  • the aqueous phase in the step 2-1) contains water, and may further contain an oily base, a higher alcohol, a thickener, a pigment, and 1,2-alkanediol or 1,3-alkanediol, and other additives. May be included.
  • a pigment and other additives may be mixed with the aqueous composition (premix) and then combined with the aqueous phase. Furthermore, in the said mixing process, the stick-shaped base material (formulation) which added the chemical
  • the heating temperature of the mixed system (and aqueous composition) in the steps 1-1) and 1-2) is preferably 50 ° C. to 90 ° C., more preferably 60 ° C. to 90 ° C., for example 70 ° C., or 80 ° C. It is.
  • This step is preferably carried out with stirring.
  • the time of heating (stirring) in each step at this time is usually about 5 to 50 minutes, although it varies depending on the type of lipid peptide compound, surfactant and other components contained in the aqueous composition, and their blending amount. .
  • the aqueous composition is uniformly dissolved.
  • the cooling temperature in the step 1-3) is, for example, room temperature to 80 ° C., room temperature to 60 ° C., or room temperature to 40 ° C. In this step, it is more preferable to cool with stirring, then stop stirring and leave to stand. In addition, it is preferable that water is 30 mass% or more and less than 80 mass% with respect to the total mass of the aqueous composition (premix) obtained by the 1) process.
  • the heating temperature of the aqueous phase and the aqueous composition (premix) is preferably 50 ° C. to 90 ° C., more preferably 60 ° C. to 90 ° C., such as 70 ° C., or 80 ° C., or 90 ° C. It is.
  • the aqueous phase is preferably heated with stirring because it contains other components such as an oily base. Heating (stirring) is usually carried out for about 5 to 50 minutes until the contained components are uniformly dissolved and dispersed. It is preferable to do.
  • the heating temperature of the aqueous phase may be the same as the heating temperature of the aqueous composition (premix).
  • the mixture obtained in the previous step is cooled to form a gel-like solid (stick-like substrate).
  • the mixture may be cooled with stirring.
  • the blending amount of water may be 20% by mass or more and less than 99% by mass with respect to the total mass of the stick-shaped substrate. preferable.
  • the obtained solid was dissolved in 120 g of tetrahydrofuran and 60 g of acetonitrile, heated to 60 ° C., stirred for 1 hour, cooled, and filtered.
  • the solid obtained here was washed with 120 g of water, dried under reduced pressure after filtration, and 26.9 g (yield 65) of white crystals of N-palmitoyl-Gly-His free form (hereinafter also simply referred to as “Pal-GH”). %).
  • Example 1 to 4 and Comparative Examples 1 to 3 (Premix preparation method) According to Table 1 below, each component was sample tube No. Weighed to 5. The pre-mix was prepared by heating the weighed composition to 70 ° C. or higher and dissolving it uniformly.
  • each component of the A phase or the above-mentioned premix is sample tube No. Weighed to 5.
  • the weighed phase A was heated to 70 ° C. or higher and dissolved uniformly.
  • another sample tube No. 5 was weighed 5.0 g of water as B phase and heated to 70 ° C. or higher. Thereafter, the A phase was added to the B phase, mixed in a heated state and stirred for about 30 seconds, and then allowed to stand and cool.
  • the solid base materials for external application of Examples 1 to 4 have a breaking strength: 0.4 to 1.3 ⁇ 10 5 Pa, and have the strength required particularly as a stick-shaped base material. Had.

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Abstract

[Problème] La présente invention vise à fournir un matériau de base en forme de bâtonnet pouvant avoir une résistance à la rupture souhaitée pour un matériau de base en forme de bâtonnet, même si la quantité de composé de peptide lipidique est réduite. [Solution] La présente invention concerne un matériau de base en forme de bâtonnet comprenant : au moins un type de tensioactif choisi dans le groupe constitué d'un composé de bétaïne et d'un éther alkylique d'éthylène glycol ; de l'eau ; un composé de peptide lipidique comprenant au moins un type choisi parmi un composé indiqué par la formule (1) ou un sel pharmaceutiquement utile de celui-ci ; au moins un type d'alcool monohydrique saturé ou insaturé en C8-3 ; et au moins un type d'épaississant choisi dans le groupe constitué d'un dérivé d'acide alginique et de carraghénane. (Dans la formule, R1 désigne un groupe aliphatique en C9-23, R2 désigne un atome hydrocarboné ou un groupe alkyle en C1-4 pouvant avoir une chaîne ramifiée en C1-2, R3 désigne un groupe –(CH2)n–X, n représente un nombre de 1 à 4, et X désigne un hétérocycle condensé comprenant un cycle de 5 chaînons, un cycle de 6 chaînons, ou un cycle de 5 chaînons et un cycle de 6 chaînons, et pouvant avoir 1 à 3 groupes amino, groupes guanidino, -CONH2, ou atomes d'azote.)
PCT/JP2018/018558 2017-05-12 2018-05-14 Matériau de base en forme de bâtonnet contenant un polysaccharide Ceased WO2018207947A1 (fr)

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US20100215726A1 (en) * 2009-02-25 2010-08-26 Peter Thomas Roth Compositions for Diminishing the Appearance of Wrinkles
WO2014003015A1 (fr) * 2012-06-25 2014-01-03 日産化学工業株式会社 Liquide de dispersion et procédé de formation d'un hydrogel
WO2016208473A1 (fr) * 2015-06-24 2016-12-29 日産化学工業株式会社 Matériau de base en bâtonnet comprenant un composé peptide lipidique

Patent Citations (3)

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US20100215726A1 (en) * 2009-02-25 2010-08-26 Peter Thomas Roth Compositions for Diminishing the Appearance of Wrinkles
WO2014003015A1 (fr) * 2012-06-25 2014-01-03 日産化学工業株式会社 Liquide de dispersion et procédé de formation d'un hydrogel
WO2016208473A1 (fr) * 2015-06-24 2016-12-29 日産化学工業株式会社 Matériau de base en bâtonnet comprenant un composé peptide lipidique

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