[go: up one dir, main page]

WO2025132575A1 - Composition cosmétique comprenant de la niacinamide et du gingérol pour le traitement de la chute des cheveux - Google Patents

Composition cosmétique comprenant de la niacinamide et du gingérol pour le traitement de la chute des cheveux Download PDF

Info

Publication number
WO2025132575A1
WO2025132575A1 PCT/EP2024/087092 EP2024087092W WO2025132575A1 WO 2025132575 A1 WO2025132575 A1 WO 2025132575A1 EP 2024087092 W EP2024087092 W EP 2024087092W WO 2025132575 A1 WO2025132575 A1 WO 2025132575A1
Authority
WO
WIPO (PCT)
Prior art keywords
gingerol
shogaol
formula
compound
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/EP2024/087092
Other languages
English (en)
Inventor
Roger Rozot
Sébastien THIBAUT
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LOreal SA
Original Assignee
LOreal SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LOreal SA filed Critical LOreal SA
Publication of WO2025132575A1 publication Critical patent/WO2025132575A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

Definitions

  • TITLE Cosmetic composition comprising niacinamide and gingerol for the treatment of hair loss
  • the present invention relates to the field of scalp and keratin fiber care, more particularly to the field of growth of keratin fibers, and prevention of their loss.
  • the present invention relates to a cosmetic composition
  • a cosmetic composition comprising:
  • the mass ratio of [compound(s) having formula (l)Zgingerol(s)] is less than or equal to 150, and when said composition comprises at least one shogaol, then the mass ratio of [gingerol(s)/shogaol(s)] is greater than or equal to 1 .
  • the invention also relates to a cosmetic treatment method comprising at least one step of applying this composition on keratin materials.
  • the invention also relates to the non- therapeutic cosmetic use of this combination to induce and/or stimulate the growth of keratin fibers and/or impede their loss and/or to treat alopecia, in particular androgenetic alopecia.
  • Hair growth and renewal are mainly determined by the activity of hair follicles and their matrix environment. Their activity is cyclic and essentially includes three phases, namely the anagen phase, the catagen phase and the telogen phase.
  • the anagen phase (active or growth phase), which lasts several years and during which hair grows longer, is succeeded by a very short and transitory catogen phase which lasts a few weeks, followed by a telogen phase or rest phase which lasts a few months. At the end of the rest period, the hair falls out and another cycle recommences. Therefore, hair is constantly being renewed and of the approximately 150,000 individual hairs on a head of hair, approximately 10% are at rest and will be replaced in the months to come. Natural hair shedding or loss can be estimated, on average, at a few hundred individual hairs per day for a normal physiological state. This continuous physical renewal process undergoes natural changes during aging, hair becomes thinner and cycles shorter. Furthermore, various causes can result in substantial temporary or definitive hair loss.
  • Hair loss in particular alopecia, is essentially due to hair renewal disturbances. These disturbances result in a first phase in cycle frequency acceleration at the cost of hair quality, and then quantity. Progressive bulb miniaturization occurs, together with isolation of said bulbs by progressive thickening of the perifollicular collagen matrix as well as of the outer sheath. Revascularization around the hair follicle is therefore made more difficult cycle after cycle. The hair recedes, getting smaller until it is merely a non-pigmented down and these phenomenon results in progressive hair thinning. The hair follicles making up a head of hair are affected in number and in average diameter. Some areas are affected preferentially, in particular on the temple or forehead hairlines in men, and in women, diffuse vertex alopecia is observed.
  • alopecia also covers a family of hair follicle disorders ultimately resulting in definitive, partial or general hair loss. It more particularly consists of androgenetic alopecia. In a large number of cases, premature hair loss occurs in genetically predisposed individuals, this consists of andro-chrono-genetic alopecia; this form of alopecia particularly concerns men. It is known, moreover, that some factors such as hormonal imbalance, physiological stress, malnutrition, can accentuate the phenomenon. Furthermore, hair loss or alteration may be linked with seasonal phenomena.
  • Hair density loss and hair loss are often perceived as distressing by those affected, in particular when they are still young.
  • Pharmacological active agents such as minoxidil, latanoprost, fluridil, spironolactone and their combinations are known.
  • composition comprising at least one compound having formula (I) and at least one gingerol in precise proportions makes it possible to modulate the level of expression of a series of genes associated with the HIF-1 biological pathway.
  • This pathway is known in the literature for its role in hair loss (F Juchaux, T Sellathurai, V Perrault, F Boirre, P Delannoy, K Bakkar, J Albaud, A Gueniche, A Cheniti, S Dal Belo, L Souverain, M Le Balch, S Commo, S Thibaut, J F Michelet.
  • the combination of at least one compound having formula (i), preferably niacinamide, or nicotinamide, or vitamin B3, with at least one gingerol, preferably in the form of extracts containing gingerols such as ginger extract, in precise proportions has advantageous properties as an active agent for inducing and/or stimulating the growth of keratin fibers such as hair, eyelashes, body hair, and eyebrows and/or impeding their loss, and in particular for treating alopecia, in particular androgenetic alopecia.
  • the invention therefore relates to a cosmetic composition
  • a cosmetic composition comprising in a physiologically acceptable medium:
  • the mass ratio of [compound(s) having formula (l)/gingerol(s)] is less than or equal to 150, and when said composition comprises at least one shogaol, then the mass ratio of [gingerol(s)/shogaol(s)] is greater than or equal to 1 .
  • the present invention also relates to a cosmetic treatment method comprising at least one step of applying a cosmetic composition according to the invention on keratin materials, to induce and/or stimulate the growth of keratin fibers and/or impede their loss.
  • the present invention also relates to a cosmetic treatment method comprising at least one step of applying a cosmetic composition according to the invention on keratin materials, to treat alopecia, in particular androgenetic alopecia.
  • the invention also relates to a non-therapeutic cosmetic use of a combination of active agents comprising:
  • the mass ratio of [compound(s) having formula (l)Zgingerol(s)] is less than or equal to 150, and when said composition comprises at least one shogaol, then the mass ratio of [gingerol(s)/shogaol(s)] is greater than or equal to 1 ; to induce and/or stimulate the growth of keratin fibers and/or impede their loss.
  • the invention also relates to a non-therapeutic cosmetic use of a combination of active agents comprising:
  • the mass ratio of [compound(s) having formula (l)/gingerol(s)] is less than or equal to 150, and when said composition comprises at least one shogaol, then the mass ratio of [gingerol(s)/shogaol(s)] is greater than or equal to 1 ; to treat alopecia, in particular androgenetic alopecia.
  • cosmetic composition means a composition comprising a physiologically acceptable medium, i.e. a medium compatible with the skin.
  • keratin materials means materials comprising keratin such as the skin, scalp and keratin fibers.
  • the keratin materials are preferably human keratin materials.
  • keratin fibers means keratin fibers, preferably human, such as hair, eyelashes, body hair and/or eyebrows, preferably eyelashes and hair, more preferably hair.
  • impede the loss of keratin fibers means to slow down or reduce keratin fiber loss.
  • "stimulate the growth of keratin fibers” means to promote or improve the growth of existing keratin fibers, in particular to increase the length and/or diameter of existing keratin fibers and/or increase the number of keratin fibers and/or increase the density of keratin fibers.
  • induce the growth of keratin fibers means to promote or improve the growth of new keratin fibers, in particular keratin fiber density (through the growth of new keratin fibers).
  • treat alopecia in particular androgenetic alopecia
  • Mass ratio of [compound(s) having formula (l)/gingerol(s)] means the mass ratio of all the compounds having formula (I) present in the composition or in the combination of active agents with respect to all the gingerols present (or total gingerols) in the composition or in the combination of active agents. It is calculated by dividing the sum of the masses of all the compounds having formula (I) by the sum of the masses of all the gingerols present.
  • Mass ratio of [gingerol(s)/shogaol(s)] means the mass ratio of all the gingerols present in the composition or in the combination of active agents with respect to all the shogaols present in the composition or in the combination of active agents. It is calculated by dividing the sum of the masses of all the gingerols present by the sum of the masses of all the shogaols present.
  • Alkyl means a monovalent linear or branched saturated hydrocarbon chain.
  • C1-C4 alkyl means an alkyl radical comprising 1 to 4 carbon ataoms such as methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tetriobutyl, and preferably methyl or ethyl.
  • C1-C4 (hydroxy)alkyl means 1-C4 alkyl radical substituted by a hydroxy radical.
  • Heterocycle means a cyclic radical of which at least one of the members denotes a heteroatom preferably chosen from N, O, S, more preferably N.
  • Salt means an addition salt with an organic or mineral acid or base.
  • the addition salts with an acid are in particular chosen from addition salts with acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, citric acid, succinic acid, tartaric acid, lactic acid, tosylic acid, benzenesulfonic acid, phosphoric acid or acetic acid.
  • the addition salts with a base are in particular chosen from addition salts with bases such as alkali metal hydroxides, alkaline earth metal hydroxides, ammonia, amines or alkanolamines.
  • composition according to the invention contains at least one compound having formula (i).
  • compositions having formula (I) have the following structure, as well as their addition salts:
  • X is the group OR or the group NRaRb
  • Ra and Rb denote independently a hydrogen atom or a C1-C4 alkyl radical such as methyl, or Ra and Rb can form together with the nitrogen atom carrying them a 5- or 6-member heterocycle, said heterocycle being optionally substituted by one or more C1-C4 (hydroxy)alkyl radicals or one or more hydroxy radicals;
  • - R denotes a hydrogen atom or a C1-C4 alkyl radical such as ethyl or a C1-C4 (hydroxy)alkyl radical.
  • Ra and Rb denote independently a hydrogen atom or a C1 -C4 alkyl radical such as methyl, more preferably Ra and Rb denote a hydrogen atom.
  • R denotes a hydrogen atom.
  • the compounds having formula (I) are chosen from the following compounds (II) and (III), mixtures thereof, as well as their salts.
  • the at least one compound having formula (I) comprises the compound (II) named niacinamide or (3-pyridinecarboxamide) also known as nicotinamide.
  • the at least one compound having formula (I) is the compound (II) named niacinamide or (3-pyridinecarboxamide) also known as nicotinamide.
  • Niacinamide PC® marketed by DSM NUTRITIONAL PRODUCTS.
  • the composition comprises from 1% to 5% by weight of compound(s) having formula (I) with respect to the total weight of the composition, preferably from 1.5% to 4.5% by weight, preferably from 2% to 4% by weight, with respect to the total weight of the composition.
  • composition according to the invention comprises at least one gingerol.
  • Gingerols are compounds of the arylalkanol family complying with the following general formula (IV):
  • gingerols complying with general formula (IV) mentioned hereinabove wherein n is equal to 2, 4, 6 or 8 and which are known under their respective names of [4]-gingerol, [6]-gingerol, [8]-gingerol and [10]-gingerol are preferably used.
  • said at least one gingerol is a mixture of gingerols.
  • said at least one gingerol is a mixture of gingerols, said mixture comprising at least [6]-gingerol.
  • said at least one gingerol is a mixture of gingerols, said mixture comprising at least [6]-gingerol at a concentration of at least 50% by weight with respect to the total weight of the gingerol mixture.
  • the composition comprises a ginger extract comprising said at least one gingerol, wherein the gingerol(s) is(are) present in the ginger extract at a concentration ranging from 10% to 35% by weight with respect to the total weight of the ginger extract, preferably 12 to 32% by weight, more preferably from 14 to 30% by weight with respect to the total weight of the ginger extract.
  • the composition comprises a ginger extract comprising said at least one gingerol, said at least one gingerol being a mixture of gingerols comprising at least [6]- gingerol present in the ginger extract at a concentration of at least 8% by weight with respect to the total weight of the ginger extract, preferably at least 10% by weight, more preferably at least 13% by weight, more preferably at least 15% by weight with respect to the total weight of the ginger extract.
  • said at least one gingerol is chosen from [6]-gingerol, [8]-gingerol, [10]- gingerol and mixtures thereof.
  • said at least one gingerol is present in the composition according to the invention at a content ranging from 0.00001 % to 1 % by weight of total gingerols with respect to the total weight of the composition, preferably from 0.0001% to 0.5%, more preferably 0.0002% to 0.1% by weight of total gingerols with respect to the total weight of the composition.
  • the composition comprises a ginger extract comprising said at least one gingerol wherein:
  • the concentration of [6]-gingerol is between 5 and 20% by weight with respect to the weight of the extract, and more preferably between 12.5 and 17.5% by weight with respect to the weight of the extract;
  • the concentration of [8]-gingerol is between 1 and 5% by weight with respect to the weight of the extract, and more preferably between 2 and 4% by weight with respect to the weight of the extract;
  • the concentration of [10]-gingerol is between 1 and 10% by weight with respect to the weight of the extract, and more preferably between 3 and 7% by weight with respect to the weight of the extract.
  • the ginger root extract can in particular be obtained by supercritical CO2 extraction from ginger root fragments, example from ginger root powder.
  • the ginger root extract used is preferably an extract obtained by supercritical CO2 extraction such as that sold under the name GINGER CO2 by FLAVEX.
  • said extract is then present preferably at a content ranging from 0.00003 to 1% by weight, preferably from 0.0001 to 0.5% by weight, more preferably 0.001 to 0.3% by weight, with respect to the total weight of the composition.
  • Said at least one gingerol can also be obtained by chemical synthesis, for example according to the methods described by BANNO and MUKAIYAMA, Bull. Chem. Soc. Japan, 49(5), 1453-1454 (1976).
  • Said at least one gingerol can also be obtained by purification or enrichment of natural plant extracts such as extracts of plants belonging to the Zingiberaceae family, in particular those belonging to the Zingiber genus, more particularly to the Zingiber officinalis species
  • the mass ratio of [compound(s) having formula (l)Zgingerol(s)] in the composition is less than or equal to 150, preferably less than or equal to 140, more preferably less than 130, advantageously it is between 0.01 and 150, preferably between 0.1 and 140, and more preferably between 0.1 and 130.
  • the mass ratio of [compound(s) having formula (II) and/or (II l)Zgingerol(s)], in the composition is less than or equal to 150, preferably less than or equal to 140, more preferably less than 130, advantageously it is between 0.01 and 150, preferably between 0.1 and 140, and more preferably between 0.1 and 130.
  • the mass ratio of [compound(s) having formula (I )/[6]- gingerol] in the composition is less than or equal to 250, preferably less than or equal to 200, more preferably less than 195, advantageously it is between 0.01 and 250, preferably between 0.1 and 200, and more preferably between 0.1 and 195.
  • the mass ratio of [compound(s) having formula (II) and/or (II l)/[6]-gingerol] in the composition is less than or equal to 250, preferably less than or equal to 200, more preferably less than 195, advantageously it is between 0.01 and 250, preferably between 0.1 and 200, and more preferably between 0.1 and 195.
  • the mass ratio of [compound(s) having formula (l)/ginger extract] in the composition is less than or equal to 40, less than or equal to 35, preferably less than or equal to 30, advantageously it is between 0.01 and 35, preferably between 0.03 and 30.
  • the composition according to the invention optionally comprises at least one shogaol.
  • Shogaols are compounds of the arylalkanone family complying with the following general formula (V):
  • shogaols complying with general formula (V) mentioned hereinabove wherein n is equal to 1 , 2, 4, 6 or 8 and which are known respectively as [3]- shogaol, [4]-shogaol, [6]-shogaol, [8]-shogaol and [10]-shogaol are preferably used.
  • said at least one shogaol is chosen from [6]-shogaol, [8]-shogaol, [10]-shogaol and mixtures thereof.
  • Shogaols can be produced when ginger is dried or cooked.
  • Shogaols can be extracted from Zingiberaceae roots by identical methods to those used for gingerol extraction.
  • said at least one shogaol is present in the composition according to the invention at a content less than 0.02% by weight of total shogaols with respect to the total weight of the composition, preferably less than 0.01%, more preferably less than 0.005%, preferably less than 0.0002%, more particularly less than 0.0001% by weight of total shogaols with respect to the total weight of the composition.
  • the composition comprises a ginger extract comprising said at least one shogaol wherein: the concentration of [6]-shogaol is between 0.1 and 5% by weight with respect to the weight of the extract, and more preferably between 1.5 and 2.5% by weight with respect to the weight of the extract; and/or the concentration of [8]-shogaol is between 0.1 and 3% by weight with respect to the weight of the extract, and more preferably between 0.3 and 0.5% by weight with respect to the weight of the extract; and/or the concentration of [10]-shogaol is between 0.01 and 1% by weight with respect to the weight of the extract, and more preferably between 0.08 and 0.2% by weight with respect to the weight of the extract.
  • said at least one shogaol can be in the form of an extract of ginger (Zingiber officinale), preferably a ginger root extract.
  • Said at least one shogaol can be in the form of extracts, by any extraction method known per se, of plants belonging to the Zingiberaceae family and, more particularly, of those belonging to the Zingiber genus and in particular to the Zingiber officinalis species (commonly referred to as ginger). More particularly, said at least one shogaol can be in the form of root extracts of these plants (also referred to here as ginger root extract).
  • the ginger root extract can be in the form of ground product, powder or liquid, it is preferably in liquid form.
  • the ginger root extract can in particular be obtained by supercritical CO2 extraction from ginger root fragments, example from ginger root powder.
  • the ginger root extract used is preferably an extract obtained by supercritical CO2 extraction such as that sold under the name GINGER CO2 by FLAVEX.
  • the composition comprises a ginger extract comprising said at least one gingerol and said at least one shogaol.
  • this ginger extract preferably of ginger root, is composed of:
  • the composition comprises a ginger extract comprising said at least one gingerol and said at least one shogaol wherein: the concentration of [6]-gingerol is between 5 and 20% by weight with respect to the weight of the extract, and more preferably between 12.5 and 17.5%; and/or the concentration of [8]-gingerol is between 1 and 5% by weight with respect to the weight of the extract, and more preferably between 2 and 4%; and/or the concentration of [10]-gingerol is between 1 and 10% by weight with respect to the weight of the extract and more preferably between 3 and 7%; and/or the concentration of [6]-shogaol is between 0.1 and 5% by weight with respect to the weight of the extract, and more preferably between 1.5 and 2.5%; and/or the concentration of [8]-shogaol is between 0.1 and 3% by weight with respect to the weight of the extract, and more preferably between 0.3 and 0.5%; and/or the concentration of [10]-shogaol is between 0.01
  • the extract can be a ginger root extract present in the composition at a content ranging from 0.02 to 1% by weight, preferably from 0.03 to 0.5% by weight, more preferably from 0.05 to 0.3% by weight, with respect to the total weight of the composition.
  • the ginger root extract used is preferably an extract obtained by supercritical CO2 extraction such as that sold under the name GINGER CO2 by FLAVEX.
  • composition according to the invention comprises at least one shogaol
  • the effect of said composition could be decreased if the mass ratio between gingerols and shogaols is strictly less than 1 .
  • the mass ratio of [gingerol(s)/shogaol(s)] is greater than or equal to 1 , preferably greater than 3, more preferably greater than 6, even more preferably greater than 9. In one preferred embodiment, this ratio is between 1 and 15, preferably between 5 and 12, more preferably between 8 and 10.
  • the mass ratio of [6], and [8], and [10]- gingerol to [6], and [8], and [10]-shogaol is greater than or equal to 3, preferably greater than 3, more preferably greater than 6, even more preferably greater than 9. In one preferred embodiment, this ratio is between 3 and 15, preferably between 5 and 12, more preferably between 8 and 10.
  • composition according to the invention does not comprise other active agents than: - at least one compound having formula (I), preferably at least one compound having formula (II) and/or (III), more preferably a compound having formula (II),
  • composition according to the invention preferably contains a physiologically acceptable medium.
  • This physiologically acceptable medium can comprise water and optionally one or more physiologically acceptable organic solvents chosen for example from lower alcohols having from 1 to 8 carbon atoms and in particular 1 to 6 carbon atoms, such as ethanol, isopropanol, propanol, butanol; polyethylene glycols having from 6 to 80 ethylene oxides; polyols such as propylene glycol, isoprene glycol, butylene glycol, glycerin, sorbitol, 1 ,3- propanediol.
  • physiologically acceptable organic solvents chosen for example from lower alcohols having from 1 to 8 carbon atoms and in particular 1 to 6 carbon atoms, such as ethanol, isopropanol, propanol, butanol; polyethylene glycols having from 6 to 80 ethylene oxides; polyols such as propylene glycol, isoprene glycol, butylene glycol, glycerin, sorbitol, 1 ,3- propanediol.
  • It can also be an anhydrous medium containing oils and/or fats other than oils.
  • the physiologically acceptable medium is an aqueous medium
  • it has a pH compatible with the skin, ranging preferably from 3 to 8 and more preferably from 4 to 7.
  • composition includes an aqueous or hydroalcoholic medium
  • a fatty (or oily) phase it is possible to add a fatty (or oily) phase to this medium.
  • composition according to the invention is in particular a composition intended for topical application on the scalp and/or keratin fibers.
  • the composition according to the invention further comprises 2,4-diaminopyrimidine-3-N-oxide (Aminexil), and/or pyridine-2,4- dicarboxylic acid diethyl ester (stemoxydine).
  • Amexil 2,4-diaminopyrimidine-3-N-oxide
  • pyridine-2,4- dicarboxylic acid diethyl ester stemoxydine
  • this composition can be in any dosage forms normally used in the field of cosmetics, such as lotion, serum, milk, cream, gel, unguent, ointment, powder, balm, patch, impregnated pad, soap, bar, mousse. It can be formulated in the form of emulsion, such as a direct oil-in-water emulsion or an invert water-in-oil emulsion.
  • the composition can take the form in particular of an aqueous or hydroalcoholic solution or suspension, an emulsion or dispersion of liquid or semi-liquid consistency obtained by dispersing a fatty phase in an aqueous phase (O/W) or conversely (W/O), a dispersion or emulsion of soft consistency, an aqueous or hydroalcoholic gel, or microcapsules or microparticles, or ionic and/or nonionic type vesicular dispersions.
  • an aqueous or hydroalcoholic solution or suspension an emulsion or dispersion of liquid or semi-liquid consistency obtained by dispersing a fatty phase in an aqueous phase (O/W) or conversely (W/O)
  • a dispersion or emulsion of soft consistency obtained by dispersing a fatty phase in an aqueous phase (O/W) or conversely (W/O)
  • a dispersion or emulsion of soft consistency an aqueous or hydroalcoholic gel,
  • composition can also be in the form of a mousse or in the form of an aerosol composition also comprising a pressurized propellant.
  • the composition can be in the form of a hair lotion, a shampoo, a conditioner, a hairstyling product (hairspray, hair setting product, styling gel), a hair mask, a cream or a foaming gel for cleaning hair.
  • a hair lotion a shampoo, a conditioner, a hairstyling product (hairspray, hair setting product, styling gel), a hair mask, a cream or a foaming gel for cleaning hair.
  • composition according to the invention is in the form of a cream or lotion, shampoo or conditioner.
  • the present invention also relates to a non-therapeutic cosmetic treatment method comprising applying the composition described hereinabove on keratin materials, to induce and/or stimulate the growth of keratin fibers and/or impede their loss.
  • the present invention also relates to a non-therapeutic cosmetic treatment method comprising applying the composition described hereinabove on keratin materials, to treat alopecia, in particular androgenetic alopecia.
  • composition described hereinabove is applied to a subject in a normal physiological state, i.e. not suffering from any pathology; alternatively to a subject not suffering from any dermatological pathology, even more preferably to a subject not suffering from any pathology of the scalp.
  • subject it should be understood herein a human being, preferably a human.
  • the method comprises applying the composition on the scalp and/or keratin fibers, then, optionally, rinsing, after setting the composition from 1 minute to 30 minutes.
  • the cosmetic composition is not rinsed.
  • the present invention relates to the non-therapeutic cosmetic use of a combination of active agents comprising:
  • the mass ratio of [compound having formula (I )/gingerol(s)] is less than or equal to 150, and when said composition comprises at least one shogaol, then the mass ratio of [gingerol(s)/shogaol(s)j is greater than or equal to 1 ; to induce and/or stimulate the growth of keratin fibers and/or impede their loss.
  • the present invention also relates to the non-therapeutic cosmetic use of a combination of active agents comprising:
  • the mass ratio of [compound having formula (l)/gingerol] is less than or equal to 150, and when said composition comprises at least one shogaol, then the mass ratio of [gingerol(s)/shogaol(s)] is greater than or equal to 1 ; to treat alopecia, in particular androgenetic alopecia.
  • the present invention relates to the non-therapeutic cosmetic use of a composition according to the invention to induce and/or stimulate the growth of keratin fibers and/or impede their loss.
  • subject it should be understood herein a human being, preferably a human.
  • Figure 1 shows a bar graph representing the HIF-1 pathway activation level according to the different niacinamide/ginger root extract mass ratios tested.
  • HIF-1 pathway activation for an anti-hair loss application
  • the purpose of this study is to compare the efficacy of the Niacinamide-Ginger root extract combination to the efficacy of both compounds when they are separated on HIF-1 pathway activation. This activation is measured thanks to monitoring of the expression level of genes under the control HIF-1alpha (Hypoxia Induced Factor 1 alpha) factor by quantitative RT- PCR.
  • Table 2 shows the effects of the niacinamide and Ginger Extract compounds, alone and in combination, on the example of a selection of genes in relation to described effects of hypoxia for an anti-hair loss benefit.
  • the results show a synergistic effect of the Niacinamide and ginger root extract combination. Indeed, treated with this combination, all the genes are expressed with a modulation factor substantially greater than 1.5 with respect to the control, which confirms the significant effect of this combination, which is not the case for the raw materials tested separately.
  • the Niacinamide-Ginger root extract combination induces a significant stimulation of the expression of the EGLN3, BNIP3, CA9 and VEGF genes which are described in the literature as being associated with the HIF-1 biological pathway (Pouyssegur J et al., MEDECINE/SCIENCES 2002; 18: 70-8).
  • the HIF-1 transcription factor When the HIF-1 transcription factor is stabilized (in hypoxic medium or following a treatment allowing its activation), it is translocated in the nucleus of the cells and activates a large number of genes, of which EGLN3, BNIP3 and CA9 and VEGF, associated with the regeneration of tissues such as the skin and hair.
  • the ginger root extracts used in the examples according to the invention contain on average 24.6% gingerols, and in particular 15.5% [6]-gingerol, 3.6% [8]-gingerol and 5.5% [10]-gingerol.
  • Table 4 shows the comparison of HIF-1 pathway activation by the implementation of the protocol as detailed in point 1, between the Niacinamide-Ginger root extract (at a ratio of 30:1 and containing 24.6% gingerols) and Niacinamide-Gingerol (at a gingerol concentration corresponding to 24.6% contained in the ginger extract) combinations.
  • the Ginger root extract can also contain Shogaols: [6]-Shogaol, [8]-Shogaol and [10]- ShogaoL
  • Table 5 shows the comparison of HIF-1 pathway activation by the implementation of the protocol as detailed in point 1 hereinabove, between the Niacinamide-gingerols and Niacinamide-gingerols-shogaols combination at different [gingerol(s)/shogaol(s)] ratios.
  • [gingerol(s)/shogaol(s)] ratio is strictly greater than 1 (0.90)
  • the activity carried by the niacinamide-gingerol(s) combination is degraded.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne une composition cosmétique comprenant : • - au moins un composé de formule (I), • - au moins un gingérol, et • - facultativement au moins un shogaol ; le ratio massique de [composé de formule (l)/gingérol] étant inférieur ou égal à 150, et lorsque ladite composition comprend au moins un shogaol, alors le ratio massique de [gingérol(s)/shogaol(s)] est supérieur ou égal à 1. L'invention concerne également un procédé de traitement cosmétique comprenant au moins une étape d'application de cette composition sur des matières kératiniques. L'invention concerne également l'utilisation cosmétique non thérapeutique de cette combinaison d'agents actifs pour induire et/ou stimuler la croissance des fibres kératiniques et/ou empêcher leur chute et/ou ladite composition pour son utilisation dans le traitement de l'alopécie, en particulier l'alopécie androgénétique.
PCT/EP2024/087092 2023-12-18 2024-12-18 Composition cosmétique comprenant de la niacinamide et du gingérol pour le traitement de la chute des cheveux Pending WO2025132575A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR2314425A FR3156651A1 (fr) 2023-12-18 2023-12-18 Composition cosmétique comprenant du niacinamide et un gingérol pour le traitement de la chute des cheveux
FRFR2314425 2023-12-18

Publications (1)

Publication Number Publication Date
WO2025132575A1 true WO2025132575A1 (fr) 2025-06-26

Family

ID=91616695

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2024/087092 Pending WO2025132575A1 (fr) 2023-12-18 2024-12-18 Composition cosmétique comprenant de la niacinamide et du gingérol pour le traitement de la chute des cheveux

Country Status (2)

Country Link
FR (1) FR3156651A1 (fr)
WO (1) WO2025132575A1 (fr)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2838336A1 (fr) 2002-04-11 2003-10-17 Oreal Utilisation d'un derive pyridine-dicarboxylate ou de l'un de ses sels pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute
WO2008049651A1 (fr) * 2006-10-26 2008-05-02 Henkel Ag & Co. Kgaa Agent cosmétique d'activité accrue comprenant de la purine et/ou des dérivés de purine
EP2772245B1 (fr) * 2013-02-27 2018-08-22 Symrise AG Extrait de gingembre pour le protection de cellules souches
CN111110618B (zh) * 2020-02-11 2022-09-27 张运适 一种用于促进毛发生长的组合物
WO2023046730A1 (fr) * 2021-09-22 2023-03-30 Bionorica Se Compositions cosmétiques comprenant du cannabidiol et un extrait de zingiber
CN116725925A (zh) * 2023-07-27 2023-09-12 章华化妆品科技有限公司 一种防脱生发精华液及其制备方法
WO2024126541A1 (fr) * 2022-12-16 2024-06-20 L'oreal Composition cosmétique comprenant de la piroctone olamine, au moins 1% de niacinamide et un extrait de racine de gingembre

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2838336A1 (fr) 2002-04-11 2003-10-17 Oreal Utilisation d'un derive pyridine-dicarboxylate ou de l'un de ses sels pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute
WO2008049651A1 (fr) * 2006-10-26 2008-05-02 Henkel Ag & Co. Kgaa Agent cosmétique d'activité accrue comprenant de la purine et/ou des dérivés de purine
EP2772245B1 (fr) * 2013-02-27 2018-08-22 Symrise AG Extrait de gingembre pour le protection de cellules souches
CN111110618B (zh) * 2020-02-11 2022-09-27 张运适 一种用于促进毛发生长的组合物
WO2023046730A1 (fr) * 2021-09-22 2023-03-30 Bionorica Se Compositions cosmétiques comprenant du cannabidiol et un extrait de zingiber
WO2024126541A1 (fr) * 2022-12-16 2024-06-20 L'oreal Composition cosmétique comprenant de la piroctone olamine, au moins 1% de niacinamide et un extrait de racine de gingembre
CN116725925A (zh) * 2023-07-27 2023-09-12 章华化妆品科技有限公司 一种防脱生发精华液及其制备方法

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BANNOMUKAIYAMA, BULL. CHEM. SOC. JAPAN, vol. 49, no. 5, 1976, pages 1453 - 1454
DATABASE GNPD [online] MINTEL; 11 February 2020 (2020-02-11), ANONYMOUS: "Anti Hair-Fall Fortifying Treatment Ampoules", XP055950324, retrieved from https://www.gnpd.com/sinatra/recordpage/7175899/ Database accession no. 7175899 *
F JUCHAUXT SELLATHURAIV PERRAULTF BOIRREP DELANNOYK BAKKARJ ALBAUDA GUENICHEA CHENITIS DAL BELO: "A combination of pyridine-2, 4-dicarboxylic acid diethyl ester and resveratrol stabilizes hypoxia-inducible factor 1-alpha and improves hair density in female volunteers", INT J COSMET SCI., vol. 42, no. 2, April 2020 (2020-04-01), pages 167 - 173
POUYSSEGUR J ET AL., MEDECINE/SCIENCES, vol. 18, 2002, pages 70 - 8
UTSA GANGULY: "Know How Niacinamide Is Beneficial For Hair", ABPLIVE, 11 June 2023 (2023-06-11), pages 1 - 4, XP093194864, Retrieved from the Internet <URL:https://news.abplive.com/lifestyle/how-niacinamide-is-beneficial-for-hair-sources-of-niacinamide-1605722> *
WATANABE Y ET AL: "Topical adenosine increases thick hair ratio in Japanese men with androgenetic alopecia", INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, KLUWER ACADEMIC PUBLISHERS, DORDRECHT, NL, vol. 37, no. 6, 18 May 2015 (2015-05-18), pages 579 - 587, XP071470289, ISSN: 0142-5463, DOI: 10.1111/ICS.12235 *

Also Published As

Publication number Publication date
FR3156651A1 (fr) 2025-06-20

Similar Documents

Publication Publication Date Title
CN103889397B (zh) 含有绿茶成分的化妆品组合物
JP4195763B2 (ja) 毛髪保護作用と毛髪減損の予防性並びにアンドロゲン性脱毛症の外因作用とその結果もたらされる毛髪減損の低下性において、改善された性質を有するヘアローション
US20130115183A1 (en) Method of preparing hair and scalp conditioning composition including aromatic oil blend with enhanced efficacy
KR101992730B1 (ko) 특정 피리딘디카복실산 유도체/항산화제 조합물
CN116096344B (zh) 用于防止脱发或促进生发的组合物
ES2739196T3 (es) Composición que comprende un éster de ácido piridindicarboxílico y un polímero de fijación, procedimiento y utilización para tratar el cabello
JP6979766B2 (ja) 毛髪の色素形成のための組成物の使用
KR100894230B1 (ko) 글루코스 및 비타민 ｆ 의 유도체 및 특정 계면활성제를함유하는 미용 또는 피부학적 조성물
JP3505200B2 (ja) 育毛剤
WO2025132575A1 (fr) Composition cosmétique comprenant de la niacinamide et du gingérol pour le traitement de la chute des cheveux
JPH0262526B2 (fr)
KR20050077310A (ko) 인디고 추출물을 이용한 모발, 눈썹 및 속눈썹 성장촉진제
KR102701789B1 (ko) 헤어 케어 조성물
BRPI0900541B1 (pt) composição de cuidado das fibras queratínicas humanas, uso cosmético e processo de tratamento cosmético das fibras queratínicas humanas e/ou do couro cabeludo
JPH10226628A (ja) 毛乳頭活性化剤
WO2023110882A1 (fr) Utilisation d&#39;un extrait aqueux-alcoolique de parties aériennes d&#39;oenothera biennis pour induire et/ou stimuler la croissance de fibres kératiniques humaines et/ou pour ralentir leur perte
JP5902184B2 (ja) 毛髪成長促進剤、睫毛と眉毛の成長促進剤、および脱毛防止剤
JPH08291026A (ja) 発育毛剤
CN104363887B (zh) 包含吡啶二甲酸酯和葡萄糖与脂肪酸的酯的组合物、方法与用途
JPH11322545A (ja) 頭皮頭髪用化粧料
KR20250138922A (ko) 갈락토마이세스 또는 스키조사카로마이세스 발효물을 유효성분으로 포함하는 탈모 방지 및 발모 촉진용 조성물
KR20240127216A (ko) 모유두세포의 기능 향상 방법 및 상기 모유두세포의 용도
JPS6143104A (ja) 養毛料
JPH1112134A (ja) 頭部用組成物
FR3156650A1 (fr) Composition cosmétique comprenant un composé apte à inhiber l’enzyme FIH-1 et un composé apte à inhiber l’enzyme PHD2 pour le traitement de la chute5 des cheveux

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 24833323

Country of ref document: EP

Kind code of ref document: A1