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WO2025152020A1 - Système de détection d'analyte - Google Patents

Système de détection d'analyte

Info

Publication number
WO2025152020A1
WO2025152020A1 PCT/CN2024/072440 CN2024072440W WO2025152020A1 WO 2025152020 A1 WO2025152020 A1 WO 2025152020A1 CN 2024072440 W CN2024072440 W CN 2024072440W WO 2025152020 A1 WO2025152020 A1 WO 2025152020A1
Authority
WO
WIPO (PCT)
Prior art keywords
bottom shell
analyte detection
detection system
present
transmitter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/CN2024/072440
Other languages
English (en)
Chinese (zh)
Inventor
杨翠军
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medtrum Technologies Inc
Original Assignee
Medtrum Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtrum Technologies Inc filed Critical Medtrum Technologies Inc
Priority to PCT/CN2024/072440 priority Critical patent/WO2025152020A1/fr
Publication of WO2025152020A1 publication Critical patent/WO2025152020A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter

Definitions

  • the present invention mainly relates to the field of medical devices, and in particular to an analyte detection system.
  • CGM continuous glucose monitoring
  • analyte detection devices The iteration of analyte detection devices is often accompanied by changes in size, and the analyte detection devices need to be installed on the user's skin surface with the help of an auxiliary installer.
  • the structure of the auxiliary installer For analyte detection devices of different sizes, the structure of the auxiliary installer must also be adjusted accordingly. When adjusting the structure of the auxiliary installer, how to reduce design, production costs and cycles is a problem that needs to be considered.
  • the prior art urgently needs an analyte detection system that can reduce design, production costs and cycles during version iterations.
  • An embodiment of the present invention discloses an analyte detection system, in which a transmitter and a bottom shell are releasably connected. After a user installs a disposable bottom shell on the skin surface through an auxiliary installer, the user can assemble a reusable transmitter on the bottom shell to form a complete analyte detection device. Before installing the bottom shell, the bottom shell and a parallel slider in the auxiliary installer can be releasably connected.
  • the present invention discloses an analyte detection system, comprising: an auxiliary mounter, comprising a parallel slider, on which a groove is arranged; an analyte detection device, comprising: a bottom shell; a transmitter, for communicating with the outside world; The device establishes a communication connection; a battery for providing power to the body fluid analyte detection device; a sensor and a conductive adhesive strip fixed on the bottom shell, the sensor includes an internal part and an external part, the external part is bent relative to the internal part, the external part is flat on the bottom shell, the internal part is used to penetrate subcutaneously to detect body fluid analyte parameter information, when the transmitter is assembled on the bottom shell, the external part establishes an electrical connection with the transmitter through the conductive adhesive strip to transmit the analyte parameter information to the transmitter; and an adhesive tape, the adhesive tape is used to stick the bottom shell to the skin surface; wherein, before installation, the bottom shell and the parallel slider can be releasably connected, the bottom shell is
  • the bottom shell is separated from the auxiliary installer, and then the emitter is assembled to the bottom shell to form a complete analyte detection device.
  • the conductive rubber strip is a rectangular parallelepiped structure.
  • the conductive rubber strip includes a conductive area and an insulating area which are spaced apart in the longitudinal direction.
  • the transmitter includes a first electrical connection area, and the first electrical connection area and the external part are electrically connected to the conductive area on the conductive rubber strip respectively.
  • the first electrical connection area and the external portion are electrically connected to the conductive areas on the adjacent structural surfaces of the conductive rubber strip, respectively.
  • At least one non-electrically connected structural surface of the conductive rubber strip is covered with an insulating material.
  • the bottom shell includes at least one first engaging portion
  • the transmitter includes at least one second engaging portion.
  • the first engaging portion engages with the second engaging portion.
  • the first engaging portion is decoupled from the second engaging portion.
  • the bottom shell includes a crease groove, and the bottom shell fails along the crease groove.
  • the crease groove includes a straight portion and a curved portion.
  • the curved portions are disposed at both ends of the straight portion.
  • the first engaging portion is distributed on the arc-surface side wall of the bottom shell.
  • the bottom case includes a battery cavity, and the battery is disposed in the battery cavity.
  • the battery cavity includes a cavity shell, and the cavity shell is used as an outer shell of the battery.
  • the battery cavity includes a detachable cavity cover.
  • the transmitter and the bottom shell can be releasably connected, and the user can After the disposable bottom shell is installed on the skin surface through the auxiliary installer, the reusable transmitter is assembled on the bottom shell to form a complete analyte detection device. Before installing the bottom shell, the bottom shell and the parallel slider in the auxiliary installer can be released and connected. When the version of the analyte detection device is iterated, if the size of the bottom shell changes, only the structure of the parallel slider needs to be changed, and the auxiliary installer can be suitable for bottom shells of different sizes to meet the version iteration requirements of the analyte detection device, reducing design and production costs and cycles.
  • the external part of the sensor is electrically connected to the electrical connection area of the transmitter on the adjacent surface of the conductive rubber strip, that is, the external part of the sensor is electrically connected to the side of the conductive rubber strip, which can reduce the overall thickness of the external part of the sensor and the conductive rubber strip, and further reduce the overall thickness of the body fluid analyte detection device, which is conducive to the miniaturized design of the detection device.
  • At least one non-electrical connection surface of the conductive rubber strip is covered with insulating material, which can prevent the non-electrical connection surface of the conductive rubber strip from being contaminated by conductive dirt such as iron filings, causing adjacent or close conductive areas to short-circuit and affect the detection signal.
  • the crease groove on the bottom shell includes a straight portion and a curved portion.
  • the combination of the straight portion and the curved portion crease groove allows the bottom shell to bend to fail while still maintaining a certain strength, thereby preventing the bottom shell from bending due to sports and other activities during daily use and causing abnormal failure, which may cause the transmitter to disconnect from the bottom shell prematurely and affect user use.
  • the cavity shell of the battery cavity can be integrally formed with the battery shell, that is, the battery cavity itself serves as the battery body, and there is no need to assemble a disposable battery or a rechargeable battery into the battery cavity.
  • the battery cavity may also include a detachable cavity cover for sealing the battery in the battery cavity, so as to facilitate the assembly of independent batteries into the battery cavity during the production process.
  • FIG. 1a is a schematic structural diagram of an auxiliary installation device according to an embodiment of the present invention.
  • FIG1b is a schematic diagram of the structure of an analyte detection device and an auxiliary installation device according to an embodiment of the present invention
  • FIG1c is a schematic diagram of the structure of the puncture structure, the parallel slider and the bottom shell in cooperation with each other according to an embodiment of the present invention
  • 2b to 2c are schematic diagrams of explosion structures of analyte detection devices according to different embodiments of the present invention.
  • FIG3 is a schematic diagram of the structure of a transmitter according to an embodiment of the present invention.
  • 5a and 5b are schematic diagrams of the structure of the bottom shell before and after failure according to an embodiment of the present invention.
  • 5c and 5d are schematic structural diagrams of the third engaging portion of the bottom shell before and after failure according to an embodiment of the present invention.
  • FIG7a is a schematic diagram of the structure of a conductive rubber strip according to an embodiment of the present invention.
  • FIG7 b is a schematic diagram of a structure in which a structural surface of a conductive rubber strip is sealed according to an embodiment of the present invention
  • 7c to 7f are schematic diagrams showing the structure of the sensor and the conductive rubber strip being assembled on the bottom shell according to an embodiment of the present invention
  • FIG. 7g is a schematic diagram of a structure in which a conductive area of a conductive rubber strip is sealed according to an embodiment of the present invention.
  • the prior art urgently needs an analyte detection system that can reduce design, production costs and cycles during version iterations.
  • the present invention provides an analyte detection system, in which an emitter and a bottom shell are releasably connected. After the user installs the disposable bottom shell on the skin surface through an auxiliary installer, the reusable emitter is assembled on the bottom shell to form a complete analyte detection device. Before installing the bottom shell, the bottom shell and a parallel slider in the auxiliary installer are releasably connected.
  • the version of the analyte detection device is iterated, if the size of the bottom shell changes, only the structure of the parallel slider needs to be changed, and the auxiliary installer can be suitable for bottom shells of different sizes, thereby meeting the version iteration requirements of the analyte detection device and reducing the design and production costs and cycles.
  • the parallel slider 203 needs to be structurally improved, for example, the groove 2031 is moved closer to the puncture structure 204 as a whole, and its circumference is also adaptively reduced with the bottom shell 101, so that the groove 2031 can accommodate the bottom shell 101, while the puncture structure 204 can still pass through the bottom shell 101 and accommodate the sensor 1032.
  • the central axis of the groove 2031 will deviate from the central axis l1 of the auxiliary mounter 20 and be in an eccentric position relative to the parallel slider 203.
  • the analyte detection device 10 includes a base housing 101 , a transmitter 102 and a sensor module 103 .
  • the transmitter 102 and the bottom shell 101 can maintain a good fixed connection, and the transmitter 102 will not be easily separated from the bottom shell 101.
  • the analyte detection device 10 is circular or approximately circular, the side walls of the bottom shell 101 and the emitter 102 are both curved or arc-shaped, and the two are compatible in shape and size.
  • At least two first engaging portions 1011 are symmetrically arranged on the curved side wall of the bottom shell 101 to constrain the transmitter 102 , and correspondingly, at least two second engaging portions 1021 are arranged at corresponding positions on the curved side wall of the transmitter 102 .
  • At least two third clamping parts 1012 and at least two fourth clamping parts 1022 may be respectively provided on the bottom shell 101 and the transmitter 102, and the position, shape and number of the fourth clamping parts 1022 correspond to those of the third clamping parts 1012.
  • the third engaging portions 1012 are also distributed on the arc-surface sidewall of the bottom shell 101 .
  • the third engaging portions 1012 are symmetrically distributed on the side wall of the bottom housing 101 .
  • the first engaging portion 1011 and the third engaging portion 1012 are both located on the side wall of the bottom shell 101, the first engaging portion 1011 is located at the left end of the side wall of the bottom shell 101, and the third engaging portion 1012 is located in the middle of the side wall of the bottom shell 101.
  • the above positions are determined by the specific shape of the transmitter 102, so that the two ends of the transmitter 102 can be respectively fixed on the bottom shell 101, thereby maintaining a tight snap connection between the transmitter 102 and the bottom shell 101.
  • the transmitter 102 can be stably fixed on the bottom shell 101 by the first engaging portion 1011 and the third engaging portion 1012 respectively engaging with the second engaging portion 1021 and the fourth engaging portion 1022. Since the transmitter 102 is reusable, when the user replaces a new analyte detection device 10, the transmitter 102 needs to be removed from the bottom shell 101. For this purpose, a solution is designed in which the bottom shell 101 can be bent and fail. When the bottom shell 101 is bent and fails, the engagement of the first engaging portion 1011 with the second engaging portion 1021 or/and the engagement of the third engaging portion 1012 with the fourth engaging portion 1022 are decoupled, thereby separating the transmitter 102 and the bottom shell 101. See below for details.
  • the x-y coordinate is the plane coordinate of the bottom shell 101
  • the crease groove 1016 is a linear groove parallel to the x-axis.
  • the fold groove 1016 can also be used in conjunction with the third engaging portion 1012 and the fourth engaging portion 1022 to complete the engagement and separation of the bottom shell 101 and the transmitter 102, as described in detail below.
  • the bottom surface of the straight portion 10161 or the curved portion 10162 may also be half hollow, that is, the bottom surfaces on both sides of the straight portion 10161 or the curved portion 10162 are discontinuously connected by the material of the bottom shell 101, and the unconnected parts are completely removed, which can reduce the overall weight of the analyte detection device 10.
  • Figures 5a and 5b are schematic diagrams of the structure of the bottom shell before and after failure of the embodiment of the present invention.
  • Figures 5c and 5d are schematic diagrams of the structure of the third engaging portion of the bottom shell before and after failure of the embodiment of the present invention.
  • the fold groove 1016 is a straight groove or a straight and curved combination groove, both ends thereof correspond to the third engaging portion 1012 and the fourth engaging portion 1022 .
  • failure is a conventional concept in the field of engineering materials. After failure, the material loses its original function and the failed part cannot be restored again. Since the third engaging portion 1012 is a part of the bottom shell 101, the failure of the bottom shell 101 includes the failure of the bottom surface, side wall or third engaging portion 1012 of the bottom shell 101. Therefore, the failure modes of the bottom shell 101 include the breakage of the bottom shell 101, the bending deformation of the bottom shell 101, and the breakage of the third engaging portion 1012. Obviously, after the bottom shell 101 fails, the bottom shell 101 loses the function and role of engaging the transmitter 102.
  • the method of fixing the fixing part includes clamping, supporting, etc., which is not specifically limited here, as long as the conditions for fixing the fixing part are met.
  • the fold groove 1016 divides the bottom shell into two sides, one side is used as the fixing part, and the other side is used as the force applying part.
  • the fixing part and the force applying part can be interchangeable.
  • the process of separating the bottom shell 101 and the transmitter 102 is as follows: fix the fixing part with a finger, and use another finger to apply a force F to the force-applying part in one direction, so that the bottom shell 101 is bent or curved, and the fourth clamping part 1022 is disengaged from the clamping of the third clamping part 1012 and decoupled, so that the transmitter 102 is separated from the bottom shell 101.
  • the bottom shell 101 is bent or curved along the crease groove 1016. The cooperation between the crease groove and the third and fourth clamping parts enables the transmitter and the bottom shell to be better separated. Leave.
  • the process of separating the bottom shell 101 and the transmitter 102 is as follows: fix the fixing portion with a finger, and use another finger to apply a force F to the force-applying portion in one direction to invalidate the third clamping portion 1012, thereby separating the third clamping portion 1012 and the fourth clamping portion 1022, so that the transmitter 102 is separated from the bottom shell 101.
  • a battery cavity 1013 is further provided on the bottom shell 101 , and a battery is installed in the battery cavity 1013 to provide electrical energy for the analyte detection device 10 .
  • the fourth engaging portion 1022 is moved in the direction of the line and the direction of the c curve until the fourth engaging portion 1022 is decoupled from the third engaging portion 1012. At this time, since the first engaging portion 1011 and the second engaging portion 1021 are not completely decoupled, the transmitter 102 and the bottom shell 101 are in a semi-connected state, which can prevent the transmitter 102 from falling off during the disassembly process. The user only needs to hold the transmitter 102 with his fingers to release the engaging state of the first engaging portion 1011 and the second engaging portion 1021 to complete the disassembly of the transmitter 102, which is easy to operate.
  • the cavity cover 10132 is connected to the cavity shell 10131 by means of bonding, snapping, welding, etc., so as to be fixed on the battery cavity 1013. It is understandable that the cavity cover 10132 is releasably connected to the cavity shell 10131 before production, or is in a separated state. After the battery is installed, the cavity cover 10132 is fixedly connected to the cavity shell 10131, and the cavity cover 10132 and the cavity shell 10131 can be completely sealed. The cavity cover 10132 cannot be removed again, so as to prevent the cavity cover 10132 from loosening and external dirt from entering the battery cavity 1013.
  • the second electrical connection area 1024 contacts and compresses the elastic conductor 1014.
  • the elastic conductor 1014 in the compressed state can be in closer contact with the second electrical connection area 1024.
  • the elastic force of the elastic conductor 1014 can also help separate the transmitter 102 from the bottom shell 101.
  • the elastic conductor 1014 may be a conductive spring, conductive rubber, etc.
  • the second electrical connection region 1024 is a metal contact.
  • the battery cavity 1013 itself serves as a battery body to provide electrical energy to the analyte detection device 10, as shown in FIG. 6 for details.
  • Fig. 6 is a schematic diagram of the X-X' cross-sectional structure of the battery cavity in Fig. 2b of an embodiment of the present invention.
  • the battery cavity 1013 includes a cavity shell 10131, and the cavity shell 10131 is integrally formed with the bottom shell 101, so that the analyte detection device 10 is more miniaturized.
  • the battery cavity 1013 includes a cavity shell 10131, a diaphragm 10133, an electrolyte 10134, a positive electrode sheet 10135, a negative electrode sheet 10136, an electrolyte isolation layer 10137 and a conductive sheet 10138.
  • the cavity shell 10131 is used to accommodate and fix the above structure, and the positive electrode sheet 10135 and the negative electrode sheet 10136 are immersed in the electrolyte 10134 and separated by the diaphragm 10133 in the middle.
  • the battery cavity 1013 itself can be used as a complete battery to provide power for the analyte detection device 10.
  • the cavity shell of the battery cavity is used as the battery shell, eliminating the shell of an independent battery.
  • the battery cavity 1013 can be more miniaturized and can accommodate more electrolyte 10131, store more power, and extend the life of the analyte detection device 10.
  • the diaphragm 10133, the positive electrode sheet 10135, and the negative electrode sheet 10136 are wound structures, and the diaphragm 10133 is located between the positive electrode sheet 10135 and the negative electrode sheet 10136.
  • the separator 10133, the positive electrode sheet 10135 and the negative electrode sheet 10136 are a stacked planar structure, and the separator 10133, the positive electrode sheet 10135 and the negative electrode sheet 10136 are spaced apart from each other.
  • the solute of the electrolyte 10134 is a lithium salt, such as one of lithium perchlorate (LiClO4), lithium hexafluorophosphate (LiPF6), and lithium tetrafluoroborate (LiBF4).
  • the solvent is one of ethylene carbonate, propylene carbonate, diethyl carbonate, dimethyl carbonate, ethyl methyl carbonate, phosphorus pentafluoride, hydrofluoric acid, ether, ethylene carbonate, propylene carbonate, and diethyl carbonate.
  • the solvent is an organic solvent, such as one of ether, ethylene carbonate, propylene carbonate and diethyl carbonate.
  • Screening of electrolytic manganese dioxide, conductive agent and binder can be done by screen or airflow classifier, and electrolytic manganese dioxide particles with a particle size less than 200um are selected, placed in a quartz boat, and heat treated in a sintering furnace at a temperature of 200°C for 4 hours.
  • the purpose of this step is to make the electrolytic manganese dioxide lose some of its bound water, shift the X-ray diffraction peak, reduce the interplanar spacing, and enhance the Mn-O bonding force, thereby enhancing the discharge capacity of the electrolytic manganese dioxide.
  • step 2 After cooling the electrolytic manganese dioxide in step 1 to below 60°C, 9g of electrolytic manganese dioxide, 0.5g of a conductive agent with a particle size of less than 200um, and 0.5g of a binder with a particle size of less than 200um are weighed using an electronic balance, placed in a grinding dish, fully stirred and mixed, and then ground manually or electrically to obtain 10g of a ground mixture, and the ground mixture is allowed to pass through a 300-mesh (particle size 48um) sieve. The purpose of this step is to ensure the uniformity of the mixture and avoid uneven dispersion of the conductive agent and additives.
  • the mass proportions of electrolytic manganese dioxide, conductive agent and binder are not limited to the above proportions, and their mass proportions may be 80%-96%, 2%-10% and 2%-10% respectively.
  • the conductive agent can be one or more of conductive carbon black, graphite, super p or carbon nanotubes.
  • the binder may be one or more of PVDF (polyvinylidene fluoride), polytetrafluoroethylene, and sodium polyacrylate.
  • PVDF polyvinylidene fluoride
  • polytetrafluoroethylene polytetrafluoroethylene
  • sodium polyacrylate sodium polyacrylate
  • the base material is one of aluminum foil or nickel foam mesh, with a thickness of 12-18um.
  • one end A of the conductive sheet 10138 is fixedly connected to the positive electrode sheet 10135 or the negative electrode sheet 10136, and the other end B of the conductive sheet 10138 passes through the electrolyte isolation layer 10137 and the cavity shell 10131, and is electrically connected to the elastic conductor 1014.
  • the end A is fixedly connected to the positive electrode sheet 10135 or the negative electrode sheet 10136 by solder or solder paste.
  • the electrolyte isolation layer 10137 is a thin film with a thickness of 300-500um. If the thickness of the electrolyte isolation layer 10137 is too small, the film material will be infiltrated and softened by the electrolyte, which will cause the film material to age after a long time. If the thickness is too large, it will occupy the internal space of the chamber. In a more preferred embodiment of the present invention, the thickness of the electrolyte isolation layer 10137 is 400um.
  • the cavity shell 10131 is made of a material resistant to corrosion by the electrolyte 10134, such as PFA (polytetrafluoroethylene) or FEP (polyperfluoroethylene propylene), the electrolyte isolation layer can be omitted.
  • Layer 10137 increases the volume of electrolyte 10134 and improves battery energy storage.
  • a sensor module is further provided on the bottom shell 101 .
  • the sensor module includes an elastic sealing ring 1031 , a sensor 1032 , and a conductive rubber strip 1033 .
  • the sensor 1032 includes an internal part 10321 and an external part 10322 .
  • the elastic sealing ring 1031 is an annular structural member, and the external part 10322 and the conductive rubber strip 1033 are both located in the inner circle of the elastic sealing ring 1031.
  • the lower end surface of the elastic sealing ring 1031 contacts the bottom surface of the bottom shell 101, and the upper end surface contacts the shell of the transmitter 102, forming a completely closed space in the inner circle of the elastic sealing ring 1031, and the external part 10322 and the conductive rubber strip 1033 are in this closed space.
  • the closed space of the elastic sealing ring 1031 can prevent dirt such as water droplets, metal chips, and blood from entering, avoiding contamination of the external part 10322 and the conductive rubber strip 1033, and affecting the detection signal.
  • Figure 7a is a schematic diagram of the structure of the conductive rubber strip according to an embodiment of the present invention.
  • Figure 7b is a schematic diagram of the structure of a conductive rubber strip according to an embodiment of the present invention where one structural surface is sealed.
  • Figures 7c to 7f are schematic diagrams of the structure of the sensor and the conductive rubber strip assembled on the bottom shell according to an embodiment of the present invention.
  • Figure 7g is a schematic diagram of the structure of the conductive area of the conductive rubber strip according to an embodiment of the present invention where the conductive area is sealed.
  • the conductive rubber strip 1033 is a three-dimensional structure having multiple structural surfaces, such as a rectangular parallelepiped structure.
  • the conductive rubber strip 1033 has conductive areas and insulating areas that are spaced apart in the longitudinal length, and both the conductive areas and the insulating areas run through the lateral direction of the conductive rubber strip 1033, where the lateral direction is perpendicular to the longitudinal direction.
  • the conductive area and the insulating area are distributed at intervals.
  • the insulating area can separate two adjacent conductive areas.
  • the insulating area has good insulating properties, which can prevent crosstalk between electrical signals of two adjacent conductive areas and ensure the stability of the detection signal.
  • the conductive rubber strip 1033 is used to electrically connect the sensor 1032 and the transmitter 102.
  • the transmitter includes a first electrical connection area 1023, and the first electrical connection area 1023 includes at least two metal contacts 10231. At least two pins (not shown in the figure) are provided on the external part 10322 of the sensor 1032. Each metal contact 10231 is respectively in contact with a different conductive area on a single structural surface of the conductive rubber strip 1033.
  • the corresponding conductive areas of the above-mentioned conductive areas on the same, adjacent or opposite structural surfaces are in contact with the pins, thereby realizing the electrical connection between the pins and the metal contacts 10231.
  • the detection signal of the sensor 1032 can be transmitted to the transmitter 102 through the conductive rubber strip 1033, and the transmitter 102 can also be transmitted through The control signal is transmitted to the sensor 1032 via the conductive rubber strip 1033 .
  • the metal contact 10231 establishes an electrical connection with the external part 10322 through the relative structural surfaces of the conductive rubber strip 1033, i.e., 1033a, 1033c or 1033b, 1033d, forming a stacked structure of the external part 10322-conductive rubber strip 1033-metal contact 10231.
  • the external part 10322 is laid flat on the bottom surface of the bottom shell 101 in a parallel state, as shown in Figure 7c.
  • a pit 1017 may be further provided on the bottom shell 101, and the external part 10322 or the conductive rubber strip 1033 may be placed in the pit 1017.
  • the external part 10322 or the conductive rubber strip 1033 may be placed in the pit 1017, and the external part 10322 or the conductive rubber strip 1033 may be fixed by interference fitting the external part 10322 or the conductive rubber strip 1033 with the pit 1017, thereby improving the assembly stability of the sensor 1032 or the conductive rubber strip 1033.
  • the external portion 10322 is electrically connected to the side structural surface 1033 c of the conductive rubber strip 1033
  • the first electrical connection area 1023 of the transmitter 102 is electrically connected to the upper structural surface 1033 d of the conductive rubber strip 1033 .
  • the external part 10322 is electrically connected to the side structural surface 1033c of the conductive adhesive strip 1033, and the first electrical connection area 1023 of the transmitter 102 is electrically connected to the upper structural surface 1033d of the conductive adhesive strip 1033.
  • the side structural surface 1033a and the lower structural surface 1033b are not used, and an insulating material can be coated or pasted on the side structural surface 1033a and/or the lower structural surface 1033b to prevent the conductive areas on these two structural surfaces from being short-circuited by dirt.
  • only 1033a is easily contaminated, so only 1033a can be coated or pasted, which can prevent the conductive area from being short-circuited by dirt and avoid insulation. Waste of edge materials.
  • the external part 10322 is electrically connected to the lower structural surface 1033b of the conductive rubber strip 1033, and the first electrical connection area 1023 of the transmitter 102 is electrically connected to the upper structural surface 1033d of the conductive rubber strip 1033.
  • the side structural surfaces 1033a and 1033c are not used, and insulating material can be coated or pasted on the side structural surfaces 1033a and/or 1033c.
  • insulating material is coated or pasted on both the side structural surfaces 1033a and 1033c to prevent the conductive areas on these two structural surfaces from being short-circuited due to dirt.
  • the insulating material may be one or more of rubber, silicone, polyethylene, glass fiber, epoxy resin, and insulating varnish, as long as good insulating properties can be achieved.
  • the insulating material may only cover the conductive area of the conductive rubber strip 1033, and may also achieve the function of insulating the non-electrically connected structural surface.
  • FIG. 7g is a top view of the conductive rubber strip 1033.
  • the first electrical connection area 1023 of the transmitter 102 is electrically connected to the upper structural surface 1033d of the conductive rubber strip 1033.
  • the conductive area on the upper structural surface 1033d that is not electrically connected to the first electrical connection area 1023 may also be contaminated by dirt and cause a short circuit. Based on this situation, the conductive area that is not electrically connected to the first electrical connection area 1023 may also be covered with an insulating material, and the insulating material is distributed at intervals on the upper structural surface 1033d.
  • the external part 10322 is electrically connected to the side structural surface 1033c of the conductive rubber strip 1033.
  • the conductive area on the side structural surface 1033c that is not electrically connected to the external part 10322 may also be contaminated by dirt and cause a short circuit. Therefore, the conductive area on the side structural surface 1033c that is not electrically connected to the external part 10322 may also be covered with an insulating material, and the insulating material is distributed at intervals on the side structural surface 1033c.
  • the conductive rubber strip 1033 is covered with insulating material on the structural surface that is not electrically connected to other components, which can better avoid short circuit caused by dirt contamination and improve the stability of the detection signal.
  • the external portion 10322 is directly laid flat on the bottom surface of the bottom shell 101, eliminating the sensor base structure, making the internal structure of the analyte detection device 10 more compact and conducive to miniaturized design.
  • the present invention discloses an analyte detection system, in which an emitter and a bottom shell are releasably connected. After the user installs the disposable bottom shell on the skin surface through an auxiliary installer, the reusable emitter is assembled on the bottom shell to form a complete analyte detection device. Before installing the bottom shell, the bottom shell and a parallel slider in the auxiliary installer are releasably connected. When the version of the analyte detection device is iterated, if the size of the bottom shell is changed, only the structure of the parallel slider needs to be changed, and the auxiliary installer can be suitable for bottom shells of different sizes, thereby meeting the version iteration requirements of the analyte detection device and reducing the design and production costs and cycles.

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  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

Est divulgué un système de détection d'analyte. Un émetteur est relié de manière amovible à un boîtier inférieur. Après que l'utilisateur installe le boîtier inférieur jetable sur la surface de la peau par l'intermédiaire d'un installateur auxiliaire, l'émetteur réutilisable est assemblé au boîtier inférieur, de façon à former un dispositif de détection d'analyte complet. Avant l'installation du boîtier inférieur, le boîtier inférieur est relié de manière amovible à un bloc coulissant parallèle dans l'installateur auxiliaire. Lorsque le dispositif de détection d'analyte est mis à niveau, un changement simple de la structure du bloc coulissant parallèle peut adapter l'installateur auxiliaire aux changements de la taille du boîtier inférieur, répondant ainsi à l'exigence de mise à jour de version/itération du dispositif de détection d'analyte et améliorant l'efficacité et l'efficacité de coût de conception et de production.
PCT/CN2024/072440 2024-01-16 2024-01-16 Système de détection d'analyte Pending WO2025152020A1 (fr)

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US20170290546A1 (en) * 2016-04-08 2017-10-12 Medtronic Minimed, Inc. Analyte sensor
CN209269702U (zh) * 2018-01-31 2019-08-20 青岛厚美德生物科技有限公司 一种植入式血糖检测装置
CN113940673A (zh) * 2019-08-19 2022-01-18 上海移宇科技股份有限公司 体液分析物检测装置
CN115868971A (zh) * 2021-09-27 2023-03-31 上海移宇科技股份有限公司 分析物检测装置安装单元及其使用方法
CN115868975A (zh) * 2021-09-27 2023-03-31 上海移宇科技股份有限公司 紧凑型分析物检测器件

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102307517A (zh) * 2009-02-03 2012-01-04 雅培糖尿病护理公司 紧凑型在体生理监测装置及其方法
US20170290546A1 (en) * 2016-04-08 2017-10-12 Medtronic Minimed, Inc. Analyte sensor
CN209269702U (zh) * 2018-01-31 2019-08-20 青岛厚美德生物科技有限公司 一种植入式血糖检测装置
CN113940673A (zh) * 2019-08-19 2022-01-18 上海移宇科技股份有限公司 体液分析物检测装置
CN116785528A (zh) * 2019-08-19 2023-09-22 上海移宇科技有限公司 高集成型药物输注装置
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