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WO2025098143A1 - 一种高保湿面霜及其制备方法 - Google Patents

一种高保湿面霜及其制备方法 Download PDF

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Publication number
WO2025098143A1
WO2025098143A1 PCT/CN2024/126837 CN2024126837W WO2025098143A1 WO 2025098143 A1 WO2025098143 A1 WO 2025098143A1 CN 2024126837 W CN2024126837 W CN 2024126837W WO 2025098143 A1 WO2025098143 A1 WO 2025098143A1
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WO
WIPO (PCT)
Prior art keywords
facial cream
highly moisturizing
moisturizing facial
highly
phase
Prior art date
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PCT/CN2024/126837
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English (en)
French (fr)
Inventor
江川霞
孙云起
孙怀庆
裴运林
郭朝万
聂艳峰
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Guangdong Marubi Biological Technology Co Ltd
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Guangdong Marubi Biological Technology Co Ltd
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Publication of WO2025098143A1 publication Critical patent/WO2025098143A1/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18

Definitions

  • the present invention belongs to the technical field of cosmetics, and in particular relates to a highly moisturizing facial cream and a preparation method thereof.
  • the basic elements of healthy skin are smoothness, fullness and elasticity. As we age, our skin gradually becomes dry, wrinkled and loose, presenting an aged appearance.
  • One of the pathological mechanisms that causes this aged appearance is the gradual decrease in the water content of the skin.
  • the water content of the stratum corneum is less than 10%, the skin becomes dry and flaky, and cracks appear in the parallel arrangement of keratinocytes.
  • the skin barrier is damaged and is easily eroded by external physical factors such as wind and cold, heat and biological factors such as microorganisms.
  • the water and electrolytes in the skin are also easily evaporated or lost. Therefore, maintaining the water content of the skin and ensuring the barrier function of the stratum corneum are the most important basic means of skin care and beauty.
  • the main function of moisturizing cream is to provide moisture and nutrition to the skin, help the skin improve problems such as dryness and dehydration, and keep the skin hydrated and healthy.
  • moisturizing methods are mainly divided into two aspects: one is to strengthen the control of water escape by enhancing the epidermal barrier function and water-locking ability of the skin; the other is to increase the body's ability to supply water to epidermal cells by activating the expression of aquaporins in the dermis of the skin.
  • the proliferation vitality of the skin cells themselves will affect the realization of the above functions.
  • the most widely used moisturizers are glycerin and hyaluronic acid, and hyaluronic acid is considered to be the moisturizer with the strongest moisturizing ability.
  • CN114081850A discloses a cosmetic high-efficiency moisturizing agent, comprising the following ingredients: glycerol polyether-26, hyaluronic acid, sodium hyaluronate cross-linked polymer, and hydroxyethyl urea.
  • the moisturizing agent prepared by the method has simple ingredients, is easy to process and produce, has a stable formula, and is easy to store; when used, it can achieve deeper absorption by the skin at the place of use, thereby enhancing the moisturizing effect; when in contact with other cosmetics, it can achieve better fusion, and can ensure the moisturizing degree of the fused body after fusion, thereby facilitating application.
  • CN107456409A discloses a moisturizing and skin-rejuvenating cosmetic, comprising the following components in mass percentage: 8-10% glycerol; 5-8% propylene glycol; 1-3% hyaluronic acid; 0.1-0.5% ascorbyl glucoside; 0.1-1% yeast extract; 1-2% oat; 0.1-1% sodium gamma-polyglutamate; 2-4% beta-glucan; and the balance is water.
  • the method can lock the moisture of the human body and prevent the loss of water from the human body by mixing low molecular weight hyaluronic acid and ascorbyl glucoside.
  • the water locking and moisturizing are carried out simultaneously.
  • the beta-glucan forms a thin film on the skin surface, which makes the skin have a good moist feeling, and can restore the damaged skin to a smooth and bright state, and has the effect of moisturizing and skin-rejuvenating.
  • CN104800096A discloses a highly effective moisturizing composition for cosmetics, which is composed of the following raw materials in percentage by weight: 1-10% glycerol, 1-10% butylene glycol, 1-10% betaine, 1-10% sodium L-lactate, 1-3% L-lactic acid, 0.5-3% carbohydrate isomers, 0.1-5% trehalose, 0.1-0.5% allantoin, 0.01-0.5% hyaluronic acid; the balance is water.
  • the product can be applied to particularly dry skin, as well as damaged skin with chapped and peeling skin, and provides a long-lasting moisturizing effect.
  • Persistent use can restore the skin's moisture and softness;
  • the pH is weakly acidic (PH4.2-5.0), which can soften the skin's stratum corneum, promote the shedding of aging and dehydrated stratum corneum cells, and maintain the skin's moisture;
  • the main moisturizing ingredients are the original ingredients in normal human skin, do not contain irritating ingredients, and can be used on normal and sensitive skin; the skin has no dependence on this product, and long-term use of this product will not have harmful effects on the skin.
  • the prior art discloses a series of moisturizing products, all of which require the addition of hyaluronic acid for moisturizing efficacy. Therefore, developing a highly moisturizing cream that can effectively increase the moisture content of the stratum corneum and reduce transepidermal water loss without adding hyaluronic acid is a research focus in this field.
  • the present invention aims to provide a highly moisturizing facial cream and a preparation method thereof, which has excellent moisturizing effect without adding hyaluronic acid.
  • the present disclosure provides a highly moisturizing facial cream, wherein the raw materials of the highly moisturizing facial cream include an emulsifier, oil, moisturizer, and preservative;
  • the moisturizer comprises lactic acid and sodium lactate
  • the moisturizer does not contain hyaluronic acid.
  • the present invention discloses a composition of adding lactic acid and sodium lactate into a facial cream, and the composition has a high water-locking ability under a specific ratio.
  • the raw materials of the highly moisturizing facial cream include, by mass percentage, 0.1-6% of emulsifier (for example, 0.2%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 5.5%, 5.9%, etc.), 10-40% of oil (for example, 12%, 14%, 16%, 18%, 20%, 22%, 24%, 26%, 28%, 30%, 32%, 34%, 36%, 38%, etc.), moisturizer 15-40% (for example, it can be 16%, 18%, 20%, 22%, 24%, 26%, 28%, 30%, 32%, 34%, 36%, 38%, etc.), preservative 0.1-6% (for example, it can be 0.2%, 0.4%, 0.6%, 0.8%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 5.5%, etc.).
  • 0.1-6% of emulsifier for example, 0.2%, 0.5%,
  • the total amount of lactic acid and sodium lactate accounts for 10-20% of the highly moisturizing facial cream, for example, it can be 12%, 14%, 16%, 18%, 19%, etc.
  • the mass ratio of lactic acid to sodium lactate is 1:(5-30), for example, it can be 1:6, 1:8, 1:10, 1:12, 1:14, 1:16, 1:18, 1:20, 1:22, 1:24, 1:26, 1:28, etc.
  • the mass ratio of lactic acid to sodium lactate is 1:(10-20).
  • the oil comprises any one of dimethicone, cetyl dimethicone, squalane, jojoba seed oil, caprylic/capric triglyceride, isononyl isononanoate, tocopherol, beeswax, isohexadecane or shea butter esters, or a combination of at least two thereof.
  • the moisturizer further comprises glycerin and/or butylene glycol.
  • the preservative includes any one of phenoxyethanol, ethylhexylglycerin, caprylyl glycol, pentylene glycol or phenoxyethanol, or a combination of at least two thereof.
  • the present disclosure provides a method for preparing the highly moisturizing facial cream as described in the first aspect, the preparation method comprising the following steps:
  • phase A The emulsifier, oil and preservative are mixed and dissolved to obtain phase A; the moisturizer is dissolved in water to obtain phase B; phase A is added to phase B and homogenized to obtain an O/W highly moisturizing facial cream.
  • the emulsifier includes cetyl PEG/PPG-10/1 polydimethylsiloxane, glyceryl stearate or PEG- Any one or a combination of at least two of 100 stearates.
  • the present disclosure provides a method for preparing the highly moisturizing facial cream as described in the first aspect, the preparation method comprising the following steps:
  • phase A The emulsifier, oil and preservative are mixed and dissolved to obtain phase A; the moisturizer is dissolved in water to obtain phase B; phase B is added to phase A and homogenized to obtain a W/O highly moisturizing cream.
  • the emulsifier includes any one of polyglyceryl-2 dipolyhydroxystearate, polyglyceryl-3 diisostearate, polyglyceryl-3 polyricinoleate, PEG-10 polydimethylsiloxane, polydimethylsiloxane PEG-10/15 crosspolymer or polyglyceryl-2 sesquioleate, or a combination of at least two thereof.
  • the present invention has the following beneficial effects:
  • composition of lactic acid and sodium lactate added to the highly moisturizing cream provided by the present disclosure can effectively increase the water content of the stratum corneum of the skin and reduce the transepidermal water loss without adding hyaluronic acid;
  • the highly moisturizing facial cream provided by the present disclosure can ensure moisturizing effect after being prepared into a W/O type or an O/W type.
  • compositions comprising, “including,” “having,” “containing,” or any other variation thereof, are intended to cover a non-exclusive inclusion.
  • a composition, process, method, article, or apparatus that comprises the listed elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.
  • This embodiment provides a highly moisturizing facial cream.
  • the raw materials of the facial cream are shown in Table 1.
  • the raw materials in the table are added in percentage by mass, and the total amount is 100%.
  • This comparative example provides a highly moisturizing facial cream.
  • the raw materials of the facial cream are shown in Table 1.
  • the raw materials in the table are added in percentage by mass, and the total amount is 100%.
  • the emulsifier, oil and preservative are mixed, stirred and dissolved at 85°C to obtain phase A; the moisturizer is mixed with water, and heated to 85°C to dissolve to obtain phase B; phase A is added to phase B, and homogenized for 5 minutes to obtain an O/W highly moisturizing cream.
  • This embodiment provides a highly moisturizing facial cream.
  • the raw materials of the facial cream are shown in Table 2.
  • the raw materials in the table are added in percentage by mass, and the total amount is 100%.
  • This comparative example provides a highly moisturizing facial cream.
  • the raw materials of the facial cream are shown in Table 2.
  • the raw materials in the table are expressed in terms of mass percentage.
  • the total amount is 100%.
  • the emulsifier, oil and preservative are mixed, stirred and dissolved at 85°C to obtain phase A; the moisturizer is mixed with water, and heated to 85°C to dissolve to obtain phase B; phase B is slowly added to phase A, and homogenized for 10 seconds to obtain a W/O highly moisturizing cream.
  • test product is applied once at a dosage of 2.0 ⁇ 0.1mg/ cm2 , and the sample is evenly applied to the ( 2cm2 ⁇ 2cm2 ) test area using a latex fingertip, and the test is performed using MPA580-CM825 and MPA4-CM825 instruments.
  • Example 1 and Examples 4-5 that the ratio of lactic acid to sodium lactate in the O/W type cream is 1:(5-30), the moisturizing effect is also very good, and the transepidermal water loss rate will increase; it can be seen from Example 1 and Comparative Examples 1-2 that lactic acid and sodium lactate work synergistically to enhance the moisturizing effect, and the use of a single ingredient will greatly reduce the moisturizing effect; it can be seen from Example 1 and Comparative Example 3 that by replacing lactic acid and sodium lactate with hyaluronic acid commonly used in the prior art of equal mass, the growth rate of stratum corneum water content decreases, and the transepidermal water loss rate increases significantly; it can be seen from Example 1 and Comparative Example 4 that when hyaluronic acid is added while using lactic acid and sodium lactate, the stratum corneum water content and transepidermal water loss rate not only do not improve, but are getting worse.
  • Example 6 and Examples 9-10 that the ratio of lactic acid to sodium lactate in the O/W type cream is 1:(5-30), the moisturizing effect is also very good, and the transepidermal water loss rate will be reduced; it can be seen from Example 6 and Comparative Examples 5-6 that lactic acid and sodium lactate work synergistically to enhance the moisturizing effect, and the use of a single ingredient will greatly reduce the moisturizing effect; it can be seen from Example 6 and Comparative Example 7 that by replacing lactic acid and sodium lactate with hyaluronic acid commonly used in the prior art of equal mass, the growth rate of stratum corneum water content decreases, and the transepidermal water loss rate increases significantly; it can be seen from Example 6 and Comparative Example 8 that when hyaluronic acid is added while using lactic acid and sodium lactate, the stratum corneum water content and transepidermal water loss rate not only do not improve, but are getting worse.
  • the present invention provides a highly moisturizing facial cream and a preparation method thereof. Without adding hyaluronic acid, the water content of the stratum corneum of the skin can be effectively increased and the transepidermal water loss can be reduced.
  • the disadvantages of moisturizing agents with added hyaluronic acid that they easily form a false slippery feeling during application and present a sticky feeling after application are overcome.
  • the cream has the characteristics of being skin-friendly and having an excellent moisturizing effect.
  • the highly moisturizing facial cream provided by the present invention is prepared into a W/O type or an O/W type, the moisturizing effect can be guaranteed, which is conducive to expanding the application scope of the highly moisturizing facial cream and the preparation method thereof.
  • the highly moisturizing facial cream and the preparation method thereof disclosed in the present invention are reproducible and can be used in a variety of industrial applications. For example, it can be applied to the field of cosmetic technology.

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Abstract

本公开提供一种高保湿面霜及其制备方法，所述高保湿面霜的原料包括乳化剂、油脂、保湿剂、防腐剂；所述保湿剂中包含乳酸和乳酸钠；所述保湿剂中不包含透明质酸。本公开提供的高保湿面霜中加入乳酸和乳酸钠的组合物，在不加入透明质酸的情况下，可以有效提高皮肤角质层含水量，降低经皮失水量，并且本公开提供的高保湿面霜在制备成W/O型或O/W型后，保湿效果都可以得到保证。

Description

一种高保湿面霜及其制备方法
相关申请的交叉引用
本申请要求于2023年11月08日提交中国专利局的申请号为202311488183.1、名称为“一种高保湿面霜及其制备方法”的中国专利申请的优先权，其全部内容通过引用结合在本申请中。
技术领域
本公开属于化妆品技术领域，具体涉及一种高保湿面霜及其制备方法。
背景技术
健康皮肤的基本要素是光滑、充盈、富有弹性。随着年龄的增加，皮肤逐渐干燥、起皱、松弛，呈现老化的外观。皮肤的含水量逐渐降低是引起这种衰老外观的病理机制之一。当角质层的水含量低于10％，皮肤干燥、脱屑，叠瓦状平行排列的角质细胞出现裂隙。皮肤屏障被损坏，容易受到外界环境物理因素如风寒、冷热以及生物因素如微生物的侵蚀，皮肤内的水、电解质也容易蒸发或流失。因此，维持皮肤的含水量，保证角质层的屏障功能是护肤美容最重要的基本手段。
保湿霜的主要作用是给肌肤提供水分和营养，帮助肌肤改善干燥和缺水等问题，使肌肤持续维持水润和健康。目前较为公认的保湿手段主要分为两个方面：一是通过增强皮肤的表皮屏障功能和锁水能力来强化对水分逃逸的控制；二是通过激活皮肤真皮层内的水通道蛋白的表达来增加体内对于表皮细胞的水分供给能力。此外，皮肤细胞本身的增殖活力状态本身就会影响上述功能的实现。使用最为广泛的保湿剂为甘油和透明质酸，且透明质酸被认为是最具保湿能力的保湿剂，但是近年来，消费者对透明质酸的爽滑感越来越抵触，主要是由于添加了透明质酸的产品在涂抹地过程中容易形成假滑感，且涂抹后呈现出粘腻感，因此，需要开发一种更亲肤、保湿效果更优异的保湿组合物极为重要。
CN114081850A公开了一种化妆品高效保湿剂，包括如下成分：甘油聚醚-26、透明质酸、透明质酸钠交联聚合物、羟乙基脲。该方法所制成的保湿剂成分简单，便于加工生产，且配方稳定，易于保存；使用时能够使使用处的皮肤达到更深层的吸收，进而增强保湿的实效；在与其他化妆品相接处的情况下，能够实现更好的融合，且能够确保融合后的融合体的保湿度，进而有利于进行涂抹使用。
CN107456409A公开了一种保湿嫩肤的化妆品，包括以下质量百分比的组分：甘油8-10％；丙二醇5-8％；透明质酸1-3％；抗坏血酸葡糖苷0.1-0.5％；酵母提取物0.1-1％；燕麦1-2％；γ-聚谷氨酸钠0.1-1％；β-葡聚糖2-4％；水余量。该方法通过低分子量透明质酸和抗坏血酸葡糖苷混合，可以锁紧人体水分，防止人体水分流失，锁水保湿为同步进行，β-葡聚糖使皮肤表面形成薄膜，使皮肤产生良好的湿润感，且可使受损的皮肤恢复至光滑柔亮的状态，具有保湿嫩肤的功效。
CN104800096A公开了一种应用于化妆品的高效保湿组合物，由以下重量百分比计的原料组成：1-10％甘油，1-10％丁二醇，1-10％甜菜碱，1-10％左旋乳酸钠，1-3％左旋乳酸，0.5-3％糖类同分异构体，0.1-5％海藻糖，0.1-0.5％尿囊素，0.01-0.5％透明质酸；余量为水。该产品可适用于特别干燥的皮肤，以及有皲裂、脱皮的受损皮肤，提供长效的保湿效果， 坚持使用可恢复皮肤水润柔软；PH为弱酸性(PH4.2-5.0)，可软化皮肤角质层，促进老化失水的角质层细胞脱落，并保持皮肤的水分；主要保湿成分为正常人体皮肤中原有成分，不含刺激性成分，可适用于普通及敏感性肌肤使用；皮肤对本品无依赖性，长期使用本品亦不会对皮肤产生有害作用。
现有技术公开了一系列保湿产品，保湿功效均需要透明质酸的加入，因此，开发一种高保湿面霜，不加入透明质酸也可以有效提高角质层水分含量，并降低经皮失水量，是本领域的研究重点。
发明内容
针对现有技术的不足，本公开的目的在于提供一种高保湿面霜及其制备方法，在未添加透明质酸的情况下保湿效果优异。
为达到此发明目的，本公开采用以下技术方案：
第一方面，本公开提供一种一种高保湿面霜，所述高保湿面霜的原料包括乳化剂、油脂、保湿剂、防腐剂；
所述保湿剂中包含乳酸和乳酸钠；
所述保湿剂中不包含透明质酸。
本公开在面霜中加入乳酸和乳酸钠的组合物，在特定比例下，该组合物具有高锁水能力。
优选地，以质量百分含量计，所述高保湿面霜的原料包括乳化剂0.1-6％(例如可以为0.2％、0.5％、1％、1.5％、2％、2.5％、3％、3.5％、4％、4.5％、5％、5.5％、5.9％等)、油脂10-40％(例如可以为12％、14％、16％、18％、20％、22％、24％、26％、28％、30％、32％、34％、36％、38％等)、保湿剂15-40％(例如可以为16％、18％、20％、22％、24％、26％、28％、30％、32％、34％、36％、38％等)、防腐剂0.1-6％(例如可以为0.2％、0.4％、0.6％、0.8％、1％、1.5％、2％、2.5％、3％、3.5％、4％、4.5％、5％、5.5％等)。
优选地，所述乳酸和乳酸钠的总量占高保湿面霜的10-20％，例如可以为12％、14％、16％、18％、19％等。
优选地，所述乳酸和乳酸钠的质量比为1:(5-30)，例如可以为1:6、1:8、1:10、1:12、1:14、1:16、1:18、1:20、1:22、1:24、1:26、1:28等。
优选地，所述乳酸和乳酸钠的质量比为1:(10-20)。
优选地，所述油脂包括聚二甲基硅氧烷、鲸蜡基聚二甲基硅氧烷、角鲨烷、霍霍巴籽油、辛酸/癸酸甘油三酯、异壬酸异壬酯、生育酚、蜂蜡、异十六烷或牛油果树果酯中的任意一种或至少两种的组合。
优选地，所述保湿剂中还包括甘油和/或丁二醇。
优选地，所述防腐剂包括苯氧乙醇、乙基己基甘油、辛甘醇、戊二醇或馨鲜酮中的任意一种或至少两种的组合。
第二方面，本公开提供一种如第一方面所述的高保湿面霜的制备方法，所述制备方法包括如下步骤：
将乳化剂、油脂和防腐剂混合溶解，得到A相；将保湿剂溶于水中，得到B相；将A相加入B相，均质，得到O/W的高保湿面霜。
优选地，所述乳化剂包括鲸蜡基PEG/PPG-10/1聚二甲基硅氧烷、甘油硬脂酸酯或PEG- 100硬脂酸酯中的任意一种或至少两种的组合。
第三方面，本公开提供一种如第一方面所述的高保湿面霜的制备方法，所述制备方法包括如下步骤：
将乳化剂、油脂和防腐剂混合溶解，得到A相；将保湿剂溶于水中，得到B相；将B相加入A相，均质，得到W/O的高保湿面霜。
优选地，所述乳化剂包括聚甘油-2二聚羟基硬脂酸酯、聚甘油-3二异硬脂酸酯、聚甘油-3聚蓖麻醇酸酯、PEG-10聚二甲基硅氧烷、聚二甲基硅氧烷PEG-10/15交联聚合物或聚甘油-2倍半油酸酯中的任意一种或至少两种的组合。
本公开所述的数值范围不仅包括上述列举的点值，还包括没有列举出的上述数值范围之间的任意的点值，限于篇幅及出于简明的考虑，本公开不再穷尽列举所述范围包括的具体点值。
相对于现有技术，本公开具有以下有益效果：
本公开提供的高保湿面霜中加入乳酸和乳酸钠的组合物，在不加入透明质酸的情况下，可以有效提高皮肤角质层含水量，降低经皮失水量；
本公开提供的高保湿面霜在制备成W/O型或O/W型后，保湿效果都可以得到保证。
具体实施方式
下面通过具体实施方式来进一步说明本公开的技术方案。本领域技术人员应该明了，所述实施例仅仅是帮助理解本公开，不应视为对本公开的具体限制。
本文所用术语“包含”、“包括”、“具有”、“含有”或其任何其它变形，意在覆盖非排它性的包括。例如，包含所列要素的组合物、步骤、方法、制品或装置不必仅限于那些要素，还可包括未明确列出的其它要素或此种组合物、步骤、方法、制品或装置所固有的要素。
“任选的”或者“任意一种”是指其后描述的事项或事件可以发生或不发生，而且该描述包括事件发生的情形和事件不发生的情形。
本公开要素或组分前的不定冠词“一种”和“一个”对要素或组分的数量要求(即出现次数)无限制性。因此“一个”或“一种”应被解读为包括一个或至少一个，并且单数形式的要素或组分也包括复数形式，除非所述数量明显只指单数形式。
本公开所描述的术语“一个实施例”、“一些实施例”、“示例性地”、“具体示例”或“一些示例”等的描述意指结合该实施例或示例描述的具体特征、结构、材料或者特点包含于本公开的至少一个实施例或示例中。在本文中，对上述术语的示意性表述不是必须针对相同的实施例或示例。
以下实施例中试剂或仪器来源如下：
本公开中，除非另有其他明确说明，否则百分比、百分含量均以质量计。如无特殊说明，所使用的实验方法均为常规方法，所用材料、试剂等均可从商业途径购买。
实施例1-5
本实施例提供一种高保湿面霜，所述面霜的原料如表1所示，表中原料以质量百分含量加入，总量为100％。
对比例1-4
本对比例提供一种高保湿面霜，所述面霜的原料如表1所示，表中原料以质量百分含量加入，总量为100％。
表1
实施例1-5、对比例1-4的制备方法为：
将乳化剂、油脂和防腐剂混合，于85℃搅拌溶解，得到A相；将保湿剂与水混合，并加热至85℃进行溶解，得到B相；将A相加入B相，均质5min，得到O/W的高保湿面霜。
实施例6-10
本实施例提供一种高保湿面霜，所述面霜的原料如表2所示，表中原料以质量百分含量加入，总量为100％。
对比例5-8
本对比例提供一种高保湿面霜，所述面霜的原料如表2所示，表中原料以质量百分含 量加入，总量为100％。
表2
实施例6-10、对比例5-8的制备方法为：
将乳化剂、油脂和防腐剂混合，于85℃搅拌溶解，得到A相；将保湿剂与水混合，并加热至85℃进行溶解，得到B相；将B相缓慢加入A相中，均质10s，得到W/O的高保湿面霜。
测试例
角质层含水量测试和经皮失水率测试
选择25-45岁健康无过敏史的女性志愿者12名，测试实施例、对比例的高保湿面霜。所有受试者均已签署知情同意书。测试时将受试者的左右前臂内侧作为受试部位进行即时 测试，对比使用产品前和使用产品30min后皮肤的角质层含水量。测试产品按照2.0±0.1mg/cm2的用量进行单次涂布，使用乳胶指套将试样均匀涂布于(2cm2×2cm2)试验区内，采用MPA580-CM825、MPA4-CM825仪器进行测试。
试用者使用实施例和对比例后的角质层含水量增长率(％)和经皮失水率(TEWL)数据如表3、表4所示。
表3
表4
根据表格数据，由实施例1-3、实施例6-8可知，本公开提供的高保湿面霜在制备成O/W型或W/O型后，乳酸和乳酸钠的比例在1:(10-20)保湿效果都很优异，并且经皮失水率大幅降低。
由实施例1、实施例4-5可知，O/W型面霜中乳酸和乳酸钠的比例在1:(5-30)，保湿效果也很好，经皮失水率会升高；由实施例1、对比例1-2可知，乳酸和乳酸钠二者协同作用共同增进保湿功效，采用单一成分均会使保湿功效大幅降低；由实施例1、对比例3可知，将乳酸和乳酸钠替换为等质量的现有技术中常用的透明质酸，角质层含水量增长率下降，且经皮失水率显著上升；由实施例1、对比例4可知，在采用乳酸和乳酸钠的同时，加入透明质酸，角质层含水量和经皮失水率不仅没有改善，却在变差。
由实施例6、实施例9-10可知，O/W型面霜中乳酸和乳酸钠的比例在1:(5-30)，保湿效果也很好，经皮失水率会降低；由实施例6、对比例5-6可知，乳酸和乳酸钠二者协同作用共同增进保湿功效，采用单一成分均会使保湿功效大幅降低；由实施例6、对比例7可知，将乳酸和乳酸钠替换为等质量的现有技术中常用的透明质酸，角质层含水量增长率下降，且经皮失水率显著上升；由实施例6、对比例8可知，在采用乳酸和乳酸钠的同时，加入透明质酸，角质层含水量和经皮失水率不仅没有改善，却在变差。
申请人声明，本公开通过上述实施例来说明本公开的工艺方法，但本公开并不局限于上述实施例，即不意味着本公开必须依赖上述实施例才能实施。所属技术领域的技术人员应该明了，对本公开的任何改进，对本公开产品各原料的等效替换及辅助成分的添加、具体方式的选择等，均落在本公开的保护范围和公开范围之内。
以上详细描述了本公开的优选实施方式，但是，本公开并不限于上述实施方式中的具体细节，在本公开的技术构思范围内，可以对本公开的技术方案进行多种简单变型，这些简单变型均属于本公开的保护范围。
另外需要说明的是，在上述具体实施方式中所描述的各个具体技术特征，在不矛盾的情况下，可以通过任何合适的方式进行组合，为了避免不必要的重复，本公开对各种可能的组合方式不再另行说明。
工业实用性
本公开提供的一种高保湿面霜及其制备方法，在不加入透明质酸的情况下，可以有效提高皮肤角质层含水量，降低经皮失水量，克服了添加透明质酸的保湿剂在涂抹地过程中容易形成假滑感且涂抹后呈现出粘腻感的缺点，具有亲肤，保湿效果优异的特点；并且本公开提供的高保湿面霜在制备成W/O型或O/W型后，保湿效果都可以得到保证，有利于扩大该高保湿面霜及其制备方法应用范围。
此外，可以理解的是，本公开的一种高保湿面霜及其制备方法是可以重现的，并且可以用在多种工业应用中。例如，可以应用于化妆品技术领域。

Claims (10)

  1. 一种高保湿面霜，其特征在于，所述高保湿面霜的原料包括乳化剂、油脂、保湿剂、防腐剂；
    所述保湿剂中包含乳酸和乳酸钠；
    所述保湿剂中不包含透明质酸。
  2. 根据权利要求1所述的高保湿面霜，其特征在于，以质量百分含量计，所述高保湿面霜的原料包括乳化剂0.1-6％、油脂10-40％、保湿剂15-40％、防腐剂0.1-6％。
  3. 根据权利要求1或2所述的高保湿面霜，其特征在于，所述乳酸和乳酸钠的总量占高保湿面霜的10-20％；
    优选地，所述乳酸和乳酸钠的质量比为1:(5-30)；
    优选地，所述乳酸和乳酸钠的质量比为1:(10-20)。
  4. 根据权利要求1-3任一项所述的高保湿面霜，其特征在于，所述油脂包括聚二甲基硅氧烷、鲸蜡基聚二甲基硅氧烷、角鲨烷、霍霍巴籽油、辛酸/癸酸甘油三酯、异壬酸异壬酯、生育酚、蜂蜡、异十六烷或牛油果树果酯中的任意一种或至少两种的组合。
  5. 根据权利要求1-4任一项所述的高保湿面霜，其特征在于，所述保湿剂中还包括甘油和/或丁二醇。
  6. 根据权利要求1-5任一项所述的高保湿面霜，其特征在于，所述防腐剂包括苯氧乙醇、乙基己基甘油、辛甘醇、戊二醇或馨鲜酮中的任意一种或至少两种的组合。
  7. 一种如权利要求1-5任一项所述的高保湿面霜的制备方法，其特征在于，所述制备方法包括如下步骤：
    将乳化剂、油脂和防腐剂混合溶解，得到A相；将保湿剂溶于水中，得到B相；将A相加入B相，均质，得到O/W的高保湿面霜。
  8. 根据权利要求7所述的制备方法，其特征在于，所述乳化剂包括鲸蜡基PEG/PPG-10/1聚二甲基硅氧烷、甘油硬脂酸酯或PEG-100硬脂酸酯中的任意一种。
  9. 一种如权利要求1-5任一项所述的高保湿面霜的制备方法，其特征在于，所述制备方法包括如下步骤：
    将乳化剂、油脂和防腐剂混合溶解，得到A相；将保湿剂溶于水中，得到B相；将B相加入A相，均质，得到W/O的高保湿面霜。
  10. 根据权利要求9所述的制备方法，其特征在于，所述乳化剂包括聚甘油-2二聚羟基硬脂酸酯、聚甘油-3二异硬脂酸酯、聚甘油-3聚蓖麻醇酸酯、PEG-10聚二甲基硅氧烷、聚二甲基硅氧烷PEG-10/15交联聚合物或聚甘油-2倍半油酸酯中的任意一种或至少两种的组合。
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