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WO2025098143A1 - Crème hautement hydratante et son procédé de préparation - Google Patents

Crème hautement hydratante et son procédé de préparation Download PDF

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Publication number
WO2025098143A1
WO2025098143A1 PCT/CN2024/126837 CN2024126837W WO2025098143A1 WO 2025098143 A1 WO2025098143 A1 WO 2025098143A1 CN 2024126837 W CN2024126837 W CN 2024126837W WO 2025098143 A1 WO2025098143 A1 WO 2025098143A1
Authority
WO
WIPO (PCT)
Prior art keywords
facial cream
highly moisturizing
moisturizing facial
highly
phase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/CN2024/126837
Other languages
English (en)
Chinese (zh)
Inventor
江川霞
孙云起
孙怀庆
裴运林
郭朝万
聂艳峰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guangdong Marubi Biological Technology Co Ltd
Original Assignee
Guangdong Marubi Biological Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guangdong Marubi Biological Technology Co Ltd filed Critical Guangdong Marubi Biological Technology Co Ltd
Publication of WO2025098143A1 publication Critical patent/WO2025098143A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18

Definitions

  • the present invention belongs to the technical field of cosmetics, and in particular relates to a highly moisturizing facial cream and a preparation method thereof.
  • the basic elements of healthy skin are smoothness, fullness and elasticity. As we age, our skin gradually becomes dry, wrinkled and loose, presenting an aged appearance.
  • One of the pathological mechanisms that causes this aged appearance is the gradual decrease in the water content of the skin.
  • the water content of the stratum corneum is less than 10%, the skin becomes dry and flaky, and cracks appear in the parallel arrangement of keratinocytes.
  • the skin barrier is damaged and is easily eroded by external physical factors such as wind and cold, heat and biological factors such as microorganisms.
  • the water and electrolytes in the skin are also easily evaporated or lost. Therefore, maintaining the water content of the skin and ensuring the barrier function of the stratum corneum are the most important basic means of skin care and beauty.
  • the main function of moisturizing cream is to provide moisture and nutrition to the skin, help the skin improve problems such as dryness and dehydration, and keep the skin hydrated and healthy.
  • moisturizing methods are mainly divided into two aspects: one is to strengthen the control of water escape by enhancing the epidermal barrier function and water-locking ability of the skin; the other is to increase the body's ability to supply water to epidermal cells by activating the expression of aquaporins in the dermis of the skin.
  • the proliferation vitality of the skin cells themselves will affect the realization of the above functions.
  • the most widely used moisturizers are glycerin and hyaluronic acid, and hyaluronic acid is considered to be the moisturizer with the strongest moisturizing ability.
  • CN114081850A discloses a cosmetic high-efficiency moisturizing agent, comprising the following ingredients: glycerol polyether-26, hyaluronic acid, sodium hyaluronate cross-linked polymer, and hydroxyethyl urea.
  • the moisturizing agent prepared by the method has simple ingredients, is easy to process and produce, has a stable formula, and is easy to store; when used, it can achieve deeper absorption by the skin at the place of use, thereby enhancing the moisturizing effect; when in contact with other cosmetics, it can achieve better fusion, and can ensure the moisturizing degree of the fused body after fusion, thereby facilitating application.
  • CN107456409A discloses a moisturizing and skin-rejuvenating cosmetic, comprising the following components in mass percentage: 8-10% glycerol; 5-8% propylene glycol; 1-3% hyaluronic acid; 0.1-0.5% ascorbyl glucoside; 0.1-1% yeast extract; 1-2% oat; 0.1-1% sodium gamma-polyglutamate; 2-4% beta-glucan; and the balance is water.
  • the method can lock the moisture of the human body and prevent the loss of water from the human body by mixing low molecular weight hyaluronic acid and ascorbyl glucoside.
  • the water locking and moisturizing are carried out simultaneously.
  • the beta-glucan forms a thin film on the skin surface, which makes the skin have a good moist feeling, and can restore the damaged skin to a smooth and bright state, and has the effect of moisturizing and skin-rejuvenating.
  • CN104800096A discloses a highly effective moisturizing composition for cosmetics, which is composed of the following raw materials in percentage by weight: 1-10% glycerol, 1-10% butylene glycol, 1-10% betaine, 1-10% sodium L-lactate, 1-3% L-lactic acid, 0.5-3% carbohydrate isomers, 0.1-5% trehalose, 0.1-0.5% allantoin, 0.01-0.5% hyaluronic acid; the balance is water.
  • the product can be applied to particularly dry skin, as well as damaged skin with chapped and peeling skin, and provides a long-lasting moisturizing effect.
  • Persistent use can restore the skin's moisture and softness;
  • the pH is weakly acidic (PH4.2-5.0), which can soften the skin's stratum corneum, promote the shedding of aging and dehydrated stratum corneum cells, and maintain the skin's moisture;
  • the main moisturizing ingredients are the original ingredients in normal human skin, do not contain irritating ingredients, and can be used on normal and sensitive skin; the skin has no dependence on this product, and long-term use of this product will not have harmful effects on the skin.
  • the prior art discloses a series of moisturizing products, all of which require the addition of hyaluronic acid for moisturizing efficacy. Therefore, developing a highly moisturizing cream that can effectively increase the moisture content of the stratum corneum and reduce transepidermal water loss without adding hyaluronic acid is a research focus in this field.
  • the present invention aims to provide a highly moisturizing facial cream and a preparation method thereof, which has excellent moisturizing effect without adding hyaluronic acid.
  • the present disclosure provides a highly moisturizing facial cream, wherein the raw materials of the highly moisturizing facial cream include an emulsifier, oil, moisturizer, and preservative;
  • the moisturizer comprises lactic acid and sodium lactate
  • the moisturizer does not contain hyaluronic acid.
  • the present invention discloses a composition of adding lactic acid and sodium lactate into a facial cream, and the composition has a high water-locking ability under a specific ratio.
  • the raw materials of the highly moisturizing facial cream include, by mass percentage, 0.1-6% of emulsifier (for example, 0.2%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 5.5%, 5.9%, etc.), 10-40% of oil (for example, 12%, 14%, 16%, 18%, 20%, 22%, 24%, 26%, 28%, 30%, 32%, 34%, 36%, 38%, etc.), moisturizer 15-40% (for example, it can be 16%, 18%, 20%, 22%, 24%, 26%, 28%, 30%, 32%, 34%, 36%, 38%, etc.), preservative 0.1-6% (for example, it can be 0.2%, 0.4%, 0.6%, 0.8%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 5.5%, etc.).
  • 0.1-6% of emulsifier for example, 0.2%, 0.5%,
  • the total amount of lactic acid and sodium lactate accounts for 10-20% of the highly moisturizing facial cream, for example, it can be 12%, 14%, 16%, 18%, 19%, etc.
  • the mass ratio of lactic acid to sodium lactate is 1:(5-30), for example, it can be 1:6, 1:8, 1:10, 1:12, 1:14, 1:16, 1:18, 1:20, 1:22, 1:24, 1:26, 1:28, etc.
  • the mass ratio of lactic acid to sodium lactate is 1:(10-20).
  • the oil comprises any one of dimethicone, cetyl dimethicone, squalane, jojoba seed oil, caprylic/capric triglyceride, isononyl isononanoate, tocopherol, beeswax, isohexadecane or shea butter esters, or a combination of at least two thereof.
  • the moisturizer further comprises glycerin and/or butylene glycol.
  • the preservative includes any one of phenoxyethanol, ethylhexylglycerin, caprylyl glycol, pentylene glycol or phenoxyethanol, or a combination of at least two thereof.
  • the present disclosure provides a method for preparing the highly moisturizing facial cream as described in the first aspect, the preparation method comprising the following steps:
  • phase A The emulsifier, oil and preservative are mixed and dissolved to obtain phase A; the moisturizer is dissolved in water to obtain phase B; phase A is added to phase B and homogenized to obtain an O/W highly moisturizing facial cream.
  • the emulsifier includes cetyl PEG/PPG-10/1 polydimethylsiloxane, glyceryl stearate or PEG- Any one or a combination of at least two of 100 stearates.
  • the present disclosure provides a method for preparing the highly moisturizing facial cream as described in the first aspect, the preparation method comprising the following steps:
  • phase A The emulsifier, oil and preservative are mixed and dissolved to obtain phase A; the moisturizer is dissolved in water to obtain phase B; phase B is added to phase A and homogenized to obtain a W/O highly moisturizing cream.
  • the emulsifier includes any one of polyglyceryl-2 dipolyhydroxystearate, polyglyceryl-3 diisostearate, polyglyceryl-3 polyricinoleate, PEG-10 polydimethylsiloxane, polydimethylsiloxane PEG-10/15 crosspolymer or polyglyceryl-2 sesquioleate, or a combination of at least two thereof.
  • the present invention has the following beneficial effects:
  • composition of lactic acid and sodium lactate added to the highly moisturizing cream provided by the present disclosure can effectively increase the water content of the stratum corneum of the skin and reduce the transepidermal water loss without adding hyaluronic acid;
  • the highly moisturizing facial cream provided by the present disclosure can ensure moisturizing effect after being prepared into a W/O type or an O/W type.
  • compositions comprising, “including,” “having,” “containing,” or any other variation thereof, are intended to cover a non-exclusive inclusion.
  • a composition, process, method, article, or apparatus that comprises the listed elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.
  • This embodiment provides a highly moisturizing facial cream.
  • the raw materials of the facial cream are shown in Table 1.
  • the raw materials in the table are added in percentage by mass, and the total amount is 100%.
  • This comparative example provides a highly moisturizing facial cream.
  • the raw materials of the facial cream are shown in Table 1.
  • the raw materials in the table are added in percentage by mass, and the total amount is 100%.
  • the emulsifier, oil and preservative are mixed, stirred and dissolved at 85°C to obtain phase A; the moisturizer is mixed with water, and heated to 85°C to dissolve to obtain phase B; phase A is added to phase B, and homogenized for 5 minutes to obtain an O/W highly moisturizing cream.
  • This embodiment provides a highly moisturizing facial cream.
  • the raw materials of the facial cream are shown in Table 2.
  • the raw materials in the table are added in percentage by mass, and the total amount is 100%.
  • This comparative example provides a highly moisturizing facial cream.
  • the raw materials of the facial cream are shown in Table 2.
  • the raw materials in the table are expressed in terms of mass percentage.
  • the total amount is 100%.
  • the emulsifier, oil and preservative are mixed, stirred and dissolved at 85°C to obtain phase A; the moisturizer is mixed with water, and heated to 85°C to dissolve to obtain phase B; phase B is slowly added to phase A, and homogenized for 10 seconds to obtain a W/O highly moisturizing cream.
  • test product is applied once at a dosage of 2.0 ⁇ 0.1mg/ cm2 , and the sample is evenly applied to the ( 2cm2 ⁇ 2cm2 ) test area using a latex fingertip, and the test is performed using MPA580-CM825 and MPA4-CM825 instruments.
  • Example 1 and Examples 4-5 that the ratio of lactic acid to sodium lactate in the O/W type cream is 1:(5-30), the moisturizing effect is also very good, and the transepidermal water loss rate will increase; it can be seen from Example 1 and Comparative Examples 1-2 that lactic acid and sodium lactate work synergistically to enhance the moisturizing effect, and the use of a single ingredient will greatly reduce the moisturizing effect; it can be seen from Example 1 and Comparative Example 3 that by replacing lactic acid and sodium lactate with hyaluronic acid commonly used in the prior art of equal mass, the growth rate of stratum corneum water content decreases, and the transepidermal water loss rate increases significantly; it can be seen from Example 1 and Comparative Example 4 that when hyaluronic acid is added while using lactic acid and sodium lactate, the stratum corneum water content and transepidermal water loss rate not only do not improve, but are getting worse.
  • Example 6 and Examples 9-10 that the ratio of lactic acid to sodium lactate in the O/W type cream is 1:(5-30), the moisturizing effect is also very good, and the transepidermal water loss rate will be reduced; it can be seen from Example 6 and Comparative Examples 5-6 that lactic acid and sodium lactate work synergistically to enhance the moisturizing effect, and the use of a single ingredient will greatly reduce the moisturizing effect; it can be seen from Example 6 and Comparative Example 7 that by replacing lactic acid and sodium lactate with hyaluronic acid commonly used in the prior art of equal mass, the growth rate of stratum corneum water content decreases, and the transepidermal water loss rate increases significantly; it can be seen from Example 6 and Comparative Example 8 that when hyaluronic acid is added while using lactic acid and sodium lactate, the stratum corneum water content and transepidermal water loss rate not only do not improve, but are getting worse.
  • the present invention provides a highly moisturizing facial cream and a preparation method thereof. Without adding hyaluronic acid, the water content of the stratum corneum of the skin can be effectively increased and the transepidermal water loss can be reduced.
  • the disadvantages of moisturizing agents with added hyaluronic acid that they easily form a false slippery feeling during application and present a sticky feeling after application are overcome.
  • the cream has the characteristics of being skin-friendly and having an excellent moisturizing effect.
  • the highly moisturizing facial cream provided by the present invention is prepared into a W/O type or an O/W type, the moisturizing effect can be guaranteed, which is conducive to expanding the application scope of the highly moisturizing facial cream and the preparation method thereof.
  • the highly moisturizing facial cream and the preparation method thereof disclosed in the present invention are reproducible and can be used in a variety of industrial applications. For example, it can be applied to the field of cosmetic technology.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Cosmetics (AREA)

Abstract

La présente divulgation propose une crème hautement hydratante et son procédé de préparation. Les matières premières de la crème hautement hydratante comprennent un émulsifiant, une huile, un hydratant et un conservateur. L'hydratant contient de l'acide lactique et du lactate de sodium, et l'hydratant ne contient pas d'acide hyaluronique. La crème hautement hydratante proposée par la présente divulgation incorpore une composition d'acide lactique et de lactate de sodium. Sans ajout d'acide hyaluronique, la crème hautement hydratante peut augmenter efficacement la teneur en eau de la couche cornée de la peau et réduire la perte d'eau transépidermique. De plus, après que la crème hautement hydratante proposée par la présente divulgation est préparée en tant que type E-H ou type H-E, l'effet hydratant peut être assuré.
PCT/CN2024/126837 2023-11-08 2024-10-23 Crème hautement hydratante et son procédé de préparation Pending WO2025098143A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202311488183.1A CN117257659B (zh) 2023-11-08 2023-11-08 一种高保湿面霜及其制备方法
CN202311488183.1 2023-11-08

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WO2025098143A1 true WO2025098143A1 (fr) 2025-05-15

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117257659B (zh) * 2023-11-08 2024-06-07 广东丸美生物技术股份有限公司 一种高保湿面霜及其制备方法

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CN105250838A (zh) * 2015-11-10 2016-01-20 广州丹奇日用化工厂有限公司 一种治疗胼胝的化妆品
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US10149814B1 (en) * 2016-04-06 2018-12-11 Brett Dines Lactic acid topical composition and method of fabricating the same
CN109199894A (zh) * 2018-10-26 2019-01-15 蔡少青 一种性能良好抗粉刺霜
CN117257659A (zh) * 2023-11-08 2023-12-22 广东丸美生物技术股份有限公司 一种高保湿面霜及其制备方法

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KR100430606B1 (ko) * 2001-11-21 2004-05-10 주식회사 코리아나화장품 락트산 및 알부틴을 포함하는 미백 화장료 조성물
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CN112641657B (zh) * 2021-01-13 2023-04-07 贵州大隆药业有限责任公司 一种保湿修护面霜及其制备方法
CN115093985B (zh) * 2022-04-24 2023-10-20 深圳市多微生保健食品有限公司 一种乳双歧杆菌及其发酵方法和应用
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Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008016298A1 (fr) * 2006-08-01 2008-02-07 Sara Lee/De N.V. Composition d'émulsion pour utilisation dans un produit de soin de la peau après épilation
CN105250838A (zh) * 2015-11-10 2016-01-20 广州丹奇日用化工厂有限公司 一种治疗胼胝的化妆品
US10149814B1 (en) * 2016-04-06 2018-12-11 Brett Dines Lactic acid topical composition and method of fabricating the same
CN105997630A (zh) * 2016-05-25 2016-10-12 广州丹奇日用化工厂有限公司 含金针菇提取物的保湿抗衰老类化妆品及其制备方法
CN109199894A (zh) * 2018-10-26 2019-01-15 蔡少青 一种性能良好抗粉刺霜
CN117257659A (zh) * 2023-11-08 2023-12-22 广东丸美生物技术股份有限公司 一种高保湿面霜及其制备方法

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