WO2025098143A1 - High-moisturizing cream and preparation method therefor - Google Patents

Abstract

The present disclosure provides a high-moisturizing cream and a preparation method therefor. Raw materials of the high-moisturizing cream comprise an emulsifier, an oil, a humectant, and a preservative. The humectant contains lactic acid and sodium lactate, and the humectant does not contain hyaluronic acid. The high-moisturizing cream provided by the present disclosure incorporates a composition of lactic acid and sodium lactate. Without the addition of hyaluronic acid, the high-moisturizing cream can effectively increase the water content of the stratum corneum of the skin and reduce the transepidermal water loss. Moreover, after the high-moisturizing cream provided by the present disclosure is prepared as either a W/O type or an O/W type, the moisturizing effect can be ensured.

Description

A kind of highly moisturizing facial cream and preparation method thereof

CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims the priority of Chinese patent application No. 202311488183.1, filed with the Chinese Patent Office on November 8, 2023, and entitled “A Highly Moisturizing Facial Cream and Its Preparation Method”, the entire contents of which are incorporated by reference into this application.

Technical Field

The present invention belongs to the technical field of cosmetics, and in particular relates to a highly moisturizing facial cream and a preparation method thereof.

Background Art

The basic elements of healthy skin are smoothness, fullness and elasticity. As we age, our skin gradually becomes dry, wrinkled and loose, presenting an aged appearance. One of the pathological mechanisms that causes this aged appearance is the gradual decrease in the water content of the skin. When the water content of the stratum corneum is less than 10%, the skin becomes dry and flaky, and cracks appear in the parallel arrangement of keratinocytes. The skin barrier is damaged and is easily eroded by external physical factors such as wind and cold, heat and biological factors such as microorganisms. The water and electrolytes in the skin are also easily evaporated or lost. Therefore, maintaining the water content of the skin and ensuring the barrier function of the stratum corneum are the most important basic means of skin care and beauty.

The main function of moisturizing cream is to provide moisture and nutrition to the skin, help the skin improve problems such as dryness and dehydration, and keep the skin hydrated and healthy. Currently, the more recognized moisturizing methods are mainly divided into two aspects: one is to strengthen the control of water escape by enhancing the epidermal barrier function and water-locking ability of the skin; the other is to increase the body's ability to supply water to epidermal cells by activating the expression of aquaporins in the dermis of the skin. In addition, the proliferation vitality of the skin cells themselves will affect the realization of the above functions. The most widely used moisturizers are glycerin and hyaluronic acid, and hyaluronic acid is considered to be the moisturizer with the strongest moisturizing ability. However, in recent years, consumers have become more and more resistant to the smooth feeling of hyaluronic acid, mainly because products with added hyaluronic acid are prone to form a false slippery feeling during the application process, and they show a sticky feeling after application. Therefore, it is extremely important to develop a more skin-friendly and moisturizing composition with better moisturizing effect.

CN114081850A discloses a cosmetic high-efficiency moisturizing agent, comprising the following ingredients: glycerol polyether-26, hyaluronic acid, sodium hyaluronate cross-linked polymer, and hydroxyethyl urea. The moisturizing agent prepared by the method has simple ingredients, is easy to process and produce, has a stable formula, and is easy to store; when used, it can achieve deeper absorption by the skin at the place of use, thereby enhancing the moisturizing effect; when in contact with other cosmetics, it can achieve better fusion, and can ensure the moisturizing degree of the fused body after fusion, thereby facilitating application.

CN107456409A discloses a moisturizing and skin-rejuvenating cosmetic, comprising the following components in mass percentage: 8-10% glycerol; 5-8% propylene glycol; 1-3% hyaluronic acid; 0.1-0.5% ascorbyl glucoside; 0.1-1% yeast extract; 1-2% oat; 0.1-1% sodium gamma-polyglutamate; 2-4% beta-glucan; and the balance is water. The method can lock the moisture of the human body and prevent the loss of water from the human body by mixing low molecular weight hyaluronic acid and ascorbyl glucoside. The water locking and moisturizing are carried out simultaneously. The beta-glucan forms a thin film on the skin surface, which makes the skin have a good moist feeling, and can restore the damaged skin to a smooth and bright state, and has the effect of moisturizing and skin-rejuvenating.

CN104800096A discloses a highly effective moisturizing composition for cosmetics, which is composed of the following raw materials in percentage by weight: 1-10% glycerol, 1-10% butylene glycol, 1-10% betaine, 1-10% sodium L-lactate, 1-3% L-lactic acid, 0.5-3% carbohydrate isomers, 0.1-5% trehalose, 0.1-0.5% allantoin, 0.01-0.5% hyaluronic acid; the balance is water. The product can be applied to particularly dry skin, as well as damaged skin with chapped and peeling skin, and provides a long-lasting moisturizing effect. Persistent use can restore the skin's moisture and softness; the pH is weakly acidic (PH4.2-5.0), which can soften the skin's stratum corneum, promote the shedding of aging and dehydrated stratum corneum cells, and maintain the skin's moisture; the main moisturizing ingredients are the original ingredients in normal human skin, do not contain irritating ingredients, and can be used on normal and sensitive skin; the skin has no dependence on this product, and long-term use of this product will not have harmful effects on the skin.

The prior art discloses a series of moisturizing products, all of which require the addition of hyaluronic acid for moisturizing efficacy. Therefore, developing a highly moisturizing cream that can effectively increase the moisture content of the stratum corneum and reduce transepidermal water loss without adding hyaluronic acid is a research focus in this field.

Summary of the invention

In view of the deficiencies in the prior art, the present invention aims to provide a highly moisturizing facial cream and a preparation method thereof, which has excellent moisturizing effect without adding hyaluronic acid.

To achieve the purpose of this invention, the present invention adopts the following technical solutions:

In a first aspect, the present disclosure provides a highly moisturizing facial cream, wherein the raw materials of the highly moisturizing facial cream include an emulsifier, oil, moisturizer, and preservative;

The moisturizer comprises lactic acid and sodium lactate;

The moisturizer does not contain hyaluronic acid.

The present invention discloses a composition of adding lactic acid and sodium lactate into a facial cream, and the composition has a high water-locking ability under a specific ratio.

Preferably, the raw materials of the highly moisturizing facial cream include, by mass percentage, 0.1-6% of emulsifier (for example, 0.2%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 5.5%, 5.9%, etc.), 10-40% of oil (for example, 12%, 14%, 16%, 18%, 20%, 22%, 24%, 26%, 28%, 30%, 32%, 34%, 36%, 38%, etc.), moisturizer 15-40% (for example, it can be 16%, 18%, 20%, 22%, 24%, 26%, 28%, 30%, 32%, 34%, 36%, 38%, etc.), preservative 0.1-6% (for example, it can be 0.2%, 0.4%, 0.6%, 0.8%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 5.5%, etc.).

Preferably, the total amount of lactic acid and sodium lactate accounts for 10-20% of the highly moisturizing facial cream, for example, it can be 12%, 14%, 16%, 18%, 19%, etc.

Preferably, the mass ratio of lactic acid to sodium lactate is 1:(5-30), for example, it can be 1:6, 1:8, 1:10, 1:12, 1:14, 1:16, 1:18, 1:20, 1:22, 1:24, 1:26, 1:28, etc.

Preferably, the mass ratio of lactic acid to sodium lactate is 1:(10-20).

Preferably, the oil comprises any one of dimethicone, cetyl dimethicone, squalane, jojoba seed oil, caprylic/capric triglyceride, isononyl isononanoate, tocopherol, beeswax, isohexadecane or shea butter esters, or a combination of at least two thereof.

Preferably, the moisturizer further comprises glycerin and/or butylene glycol.

Preferably, the preservative includes any one of phenoxyethanol, ethylhexylglycerin, caprylyl glycol, pentylene glycol or phenoxyethanol, or a combination of at least two thereof.

In a second aspect, the present disclosure provides a method for preparing the highly moisturizing facial cream as described in the first aspect, the preparation method comprising the following steps:

The emulsifier, oil and preservative are mixed and dissolved to obtain phase A; the moisturizer is dissolved in water to obtain phase B; phase A is added to phase B and homogenized to obtain an O/W highly moisturizing facial cream.

Preferably, the emulsifier includes cetyl PEG/PPG-10/1 polydimethylsiloxane, glyceryl stearate or PEG- Any one or a combination of at least two of 100 stearates.

In a third aspect, the present disclosure provides a method for preparing the highly moisturizing facial cream as described in the first aspect, the preparation method comprising the following steps:

The emulsifier, oil and preservative are mixed and dissolved to obtain phase A; the moisturizer is dissolved in water to obtain phase B; phase B is added to phase A and homogenized to obtain a W/O highly moisturizing cream.

Preferably, the emulsifier includes any one of polyglyceryl-2 dipolyhydroxystearate, polyglyceryl-3 diisostearate, polyglyceryl-3 polyricinoleate, PEG-10 polydimethylsiloxane, polydimethylsiloxane PEG-10/15 crosspolymer or polyglyceryl-2 sesquioleate, or a combination of at least two thereof.

The numerical range described in the present disclosure includes not only the point values listed above, but also any point values between the above numerical ranges that are not listed. Due to space limitations and for the sake of brevity, the present disclosure no longer exhaustively lists the specific point values included in the range.

Compared with the prior art, the present invention has the following beneficial effects:

The composition of lactic acid and sodium lactate added to the highly moisturizing cream provided by the present disclosure can effectively increase the water content of the stratum corneum of the skin and reduce the transepidermal water loss without adding hyaluronic acid;

The highly moisturizing facial cream provided by the present disclosure can ensure moisturizing effect after being prepared into a W/O type or an O/W type.

DETAILED DESCRIPTION

The technical solution of the present disclosure is further described below through specific implementation methods. Those skilled in the art should understand that the embodiments are only to help understand the present disclosure and should not be regarded as specific limitations of the present disclosure.

As used herein, the terms "comprises," "including," "having," "containing," or any other variation thereof, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises the listed elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.

"Optional" or "any one" means that the subsequently described matter or event can or cannot occur, and that the description includes instances where the event occurs and instances where it does not.

The indefinite articles "a" and "an" before the elements or components of the present disclosure have no restrictions on the quantity requirements (i.e., the number of occurrences) of the elements or components. Therefore, "a" or "an" should be interpreted as including one or at least one, and the elements or components in the singular form also include the plural form, unless the quantity obviously refers to the singular form only.

The description of the terms "one embodiment", "some embodiments", "exemplarily", "specific example" or "some examples" described in the present disclosure means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present disclosure. In this document, the schematic representation of the above terms does not necessarily refer to the same embodiment or example.

The sources of reagents or instruments in the following examples are as follows:

In the present disclosure, unless otherwise explicitly stated, percentages and contents are all by mass. Unless otherwise specified, the experimental methods used are all conventional methods, and the materials and reagents used can be purchased from commercial sources.

Examples 1-5

This embodiment provides a highly moisturizing facial cream. The raw materials of the facial cream are shown in Table 1. The raw materials in the table are added in percentage by mass, and the total amount is 100%.

Comparative Examples 1-4

This comparative example provides a highly moisturizing facial cream. The raw materials of the facial cream are shown in Table 1. The raw materials in the table are added in percentage by mass, and the total amount is 100%.

Table 1

The preparation methods of Examples 1-5 and Comparative Examples 1-4 are:

The emulsifier, oil and preservative are mixed, stirred and dissolved at 85°C to obtain phase A; the moisturizer is mixed with water, and heated to 85°C to dissolve to obtain phase B; phase A is added to phase B, and homogenized for 5 minutes to obtain an O/W highly moisturizing cream.

Embodiment 6-10

This embodiment provides a highly moisturizing facial cream. The raw materials of the facial cream are shown in Table 2. The raw materials in the table are added in percentage by mass, and the total amount is 100%.

Comparative Examples 5-8

This comparative example provides a highly moisturizing facial cream. The raw materials of the facial cream are shown in Table 2. The raw materials in the table are expressed in terms of mass percentage. The total amount is 100%.

Table 2

The preparation methods of Examples 6-10 and Comparative Examples 5-8 are:

The emulsifier, oil and preservative are mixed, stirred and dissolved at 85°C to obtain phase A; the moisturizer is mixed with water, and heated to 85°C to dissolve to obtain phase B; phase B is slowly added to phase A, and homogenized for 10 seconds to obtain a W/O highly moisturizing cream.

Test Case

Stratum corneum moisture content test and transepidermal water loss test

Twelve healthy female volunteers aged 25-45 years with no history of allergies were selected to test the highly moisturizing facial creams of the embodiments and comparative examples. All subjects signed informed consent. During the test, the inner sides of the left and right forearms of the subjects were used as the test sites for immediate Test, compare the moisture content of the stratum corneum of the skin before and 30 minutes after using the product. The test product is applied once at a dosage of 2.0±0.1mg/ ^cm2 , and the sample is evenly applied to the ( ^2cm2 × ^2cm2 ) test area using a latex fingertip, and the test is performed using MPA580-CM825 and MPA4-CM825 instruments.

The data of the stratum corneum water content growth rate (%) and transepidermal water loss (TEWL) after the test subjects used the embodiments and comparative examples are shown in Tables 3 and 4.

Table 3

Table 4

According to the data in the table, it can be seen from Examples 1-3 and Examples 6-8 that after the highly moisturizing facial cream provided by the present invention is prepared into an O/W type or W/O type, the ratio of lactic acid to sodium lactate is 1:(10-20), the moisturizing effect is excellent, and the transepidermal water loss rate is greatly reduced.

It can be seen from Example 1 and Examples 4-5 that the ratio of lactic acid to sodium lactate in the O/W type cream is 1:(5-30), the moisturizing effect is also very good, and the transepidermal water loss rate will increase; it can be seen from Example 1 and Comparative Examples 1-2 that lactic acid and sodium lactate work synergistically to enhance the moisturizing effect, and the use of a single ingredient will greatly reduce the moisturizing effect; it can be seen from Example 1 and Comparative Example 3 that by replacing lactic acid and sodium lactate with hyaluronic acid commonly used in the prior art of equal mass, the growth rate of stratum corneum water content decreases, and the transepidermal water loss rate increases significantly; it can be seen from Example 1 and Comparative Example 4 that when hyaluronic acid is added while using lactic acid and sodium lactate, the stratum corneum water content and transepidermal water loss rate not only do not improve, but are getting worse.

It can be seen from Example 6 and Examples 9-10 that the ratio of lactic acid to sodium lactate in the O/W type cream is 1:(5-30), the moisturizing effect is also very good, and the transepidermal water loss rate will be reduced; it can be seen from Example 6 and Comparative Examples 5-6 that lactic acid and sodium lactate work synergistically to enhance the moisturizing effect, and the use of a single ingredient will greatly reduce the moisturizing effect; it can be seen from Example 6 and Comparative Example 7 that by replacing lactic acid and sodium lactate with hyaluronic acid commonly used in the prior art of equal mass, the growth rate of stratum corneum water content decreases, and the transepidermal water loss rate increases significantly; it can be seen from Example 6 and Comparative Example 8 that when hyaluronic acid is added while using lactic acid and sodium lactate, the stratum corneum water content and transepidermal water loss rate not only do not improve, but are getting worse.

The applicant declares that the present disclosure uses the above-mentioned embodiments to illustrate the process method of the present disclosure, but the present disclosure is not limited to the above-mentioned embodiments, that is, it does not mean that the present disclosure must rely on the above-mentioned embodiments to be implemented. Those skilled in the art should understand that any improvement to the present disclosure, equivalent replacement of various raw materials of the product of the present disclosure, addition of auxiliary components, selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present disclosure.

The preferred embodiments of the present disclosure are described in detail above; however, the present disclosure is not limited to the specific details in the above embodiments. Within the technical concept of the present disclosure, a variety of simple modifications can be made to the technical solution of the present disclosure, and these simple modifications all fall within the protection scope of the present disclosure.

It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present disclosure will not further describe various possible combinations.

Industrial Applicability

The present invention provides a highly moisturizing facial cream and a preparation method thereof. Without adding hyaluronic acid, the water content of the stratum corneum of the skin can be effectively increased and the transepidermal water loss can be reduced. The disadvantages of moisturizing agents with added hyaluronic acid that they easily form a false slippery feeling during application and present a sticky feeling after application are overcome. The cream has the characteristics of being skin-friendly and having an excellent moisturizing effect. Moreover, after the highly moisturizing facial cream provided by the present invention is prepared into a W/O type or an O/W type, the moisturizing effect can be guaranteed, which is conducive to expanding the application scope of the highly moisturizing facial cream and the preparation method thereof.

In addition, it is understood that the highly moisturizing facial cream and the preparation method thereof disclosed in the present invention are reproducible and can be used in a variety of industrial applications. For example, it can be applied to the field of cosmetic technology.

Claims (10)

A highly moisturizing facial cream, characterized in that the raw materials of the highly moisturizing facial cream include emulsifier, oil, moisturizer, and preservative; The moisturizer comprises lactic acid and sodium lactate; The moisturizer does not contain hyaluronic acid. The highly moisturizing facial cream according to claim 1 is characterized in that, in terms of mass percentage, the raw materials of the highly moisturizing facial cream include 0.1-6% emulsifier, 10-40% oil, 15-40% moisturizer, and 0.1-6% preservative. The highly moisturizing facial cream according to claim 1 or 2, characterized in that the total amount of the lactic acid and sodium lactate accounts for 10-20% of the highly moisturizing facial cream; Preferably, the mass ratio of lactic acid to sodium lactate is 1:(5-30); Preferably, the mass ratio of lactic acid to sodium lactate is 1:(10-20). The highly moisturizing facial cream according to any one of claims 1 to 3, characterized in that the oil comprises any one of polydimethylsiloxane, cetyl polydimethylsiloxane, squalane, jojoba seed oil, caprylic/capric triglyceride, isononyl isononanoate, tocopherol, beeswax, isohexadecane or a combination of at least two of them. The highly moisturizing facial cream according to any one of claims 1 to 4, characterized in that the moisturizing agent further comprises glycerin and/or butylene glycol. The highly moisturizing facial cream according to any one of claims 1 to 5, characterized in that the preservative comprises any one of phenoxyethanol, ethylhexylglycerin, caprylyl glycol, pentylene glycol or cinnamaldehyde, or a combination of at least two thereof. A method for preparing the highly moisturizing facial cream according to any one of claims 1 to 5, characterized in that the preparation method comprises the following steps: The emulsifier, oil and preservative are mixed and dissolved to obtain phase A; the moisturizer is dissolved in water to obtain phase B; phase A is added to phase B and homogenized to obtain an O/W highly moisturizing facial cream. The preparation method according to claim 7, characterized in that the emulsifier includes any one of cetyl PEG/PPG-10/1 polydimethylsiloxane, glyceryl stearate or PEG-100 stearate. A method for preparing the highly moisturizing facial cream according to any one of claims 1 to 5, characterized in that the preparation method comprises the following steps: The emulsifier, oil and preservative are mixed and dissolved to obtain phase A; the moisturizer is dissolved in water to obtain phase B; phase B is added to phase A and homogenized to obtain a W/O highly moisturizing cream. The preparation method according to claim 9, characterized in that the emulsifier includes any one of polyglyceryl-2 dipolyhydroxystearate, polyglyceryl-3 diisostearate, polyglyceryl-3 polyricinoleate, PEG-10 polydimethylsiloxane, polydimethylsiloxane PEG-10/15 crosspolymer or polyglyceryl-2 sesquioleate, or a combination of at least two thereof.