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WO2020239083A1 - Système de génération d'aérosol ou système à fumer, ou cigarette électronique et dispositif associé - Google Patents

Système de génération d'aérosol ou système à fumer, ou cigarette électronique et dispositif associé Download PDF

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Publication number
WO2020239083A1
WO2020239083A1 PCT/CN2020/093337 CN2020093337W WO2020239083A1 WO 2020239083 A1 WO2020239083 A1 WO 2020239083A1 CN 2020093337 W CN2020093337 W CN 2020093337W WO 2020239083 A1 WO2020239083 A1 WO 2020239083A1
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Prior art keywords
acid
nicotine
aerosol
salt
electronic cigarette
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PCT/CN2020/093337
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English (en)
Chinese (zh)
Inventor
钟术光
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Individual
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Priority claimed from CN201910470024.6A external-priority patent/CN110150760A/zh
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    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/10—Devices using liquid inhalable precursors
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
    • A24F40/42—Cartridges or containers for inhalable precursors

Definitions

  • the present invention relates to an aerosol generation or aerosolization system or an electronic cigarette and a device thereof, and more specifically, to an aerosol generation or aerosolization system or an electronic cigarette and a device thereof that are well experienced by consumers.
  • Nicotine is an important material basis for the sensory quality of tobacco and tobacco products. Nicotine can act on the human central nervous system to cause corresponding physiological reactions. A proper amount of nicotine intake can refresh the brain, eliminate pain and increase nerve excitement. Long-term use can cause addiction.
  • the application of nicotine can bring satisfaction, and the conventional method is by smoking, such as smoking cigarettes, cigars or pipe tobacco, or by smelling or chewing tobacco.
  • smoking such as smoking cigarettes, cigars or pipe tobacco
  • smelling or chewing tobacco due to the formation of a large amount of harmful substances during the burning of tobacco, such as carcinogenic tar products, carbon monoxide, aldehydes and hydrocyanic acid, smoking has serious health risks. Therefore, it is desired to form an alternative way of comfortable administration of nicotine, which can be used to promote Quit smoking and/or replace smoking.
  • e-cigarette liquid the main components of e-cigarette liquid are usually solvents (propylene glycol and glycerol, the total content is generally more than 90%), nicotine (generally content is 0-3%) and flavor substances (according to different tastes, such as tobacco, Mint, coffee, fruit, etc., add different fragrance ingredients).
  • solvents propylene glycol and glycerol, the total content is generally more than 90%
  • nicotine generally content is 0-3%
  • flavor substances accordinging to different tastes, such as tobacco, Mint, coffee, fruit, etc., add different fragrance ingredients.
  • most of the e-cigarette liquids sold on the market are too sweet and greasy in the mouth after inhalation, the tobacco flavor is too weak, and the strength is insufficient, which cannot meet the needs of consumers, which severely restricts the development of e-cigarettes.
  • the main reason is that the content of free nicotine in the smoke liquid is too small.
  • Cigarette strength is related to the content of nicotine in tobacco and mainstream smoke, especially the free nicotine in it.
  • the physiological satisfaction of cigarette smoking is mainly determined by the total intake of nicotine and the speed at which it enters the blood system.
  • Armitage et al. found that free nicotine is more lipophilic than proton nicotine, and it is easier to penetrate the oral mucosa and be absorbed by the body more quickly.
  • the intensity of physical stimulation and the intensity of smoke produced during smoking are related to the content of free nicotine in the smoke. The higher the content, the greater the intensity.
  • Patent CN201510942417.4 discloses an e-cigarette liquid containing a pH adjuster, the e-cigarette liquid includes 1-10% by mass of a pH adjuster, and the pH of the e-cigarette liquid is pH 7.2 to pH 8. 9.
  • the e-cigarette liquid increases the release of free nicotine and improves the physiological satisfaction of the e-cigarette to a certain extent.
  • nicotine is easy to oxidize and degrade, easy to volatilize, and has poor throat and oral properties.
  • Patent CN104473322A "discloses an e-cigarette liquid containing nicotine and organic acid: nicotine, organic acid and e-cigarette-forming agent are mixed uniformly in proportions to obtain e-cigarette liquid; among them, 1ml of e-cigarette liquid
  • the content of base is 1-30mg; the organic acid is monocarboxylic acid or dicarboxylic acid; the molar ratio of monocarboxylic acid to nicotine is not more than 0.5, and the molar ratio of dicarboxylic acid to nicotine is not more than 0.25".
  • This technology attempts to "mix nicotine, organic acids and aerosols to form organic acid nicotine salts, and then through the heating process of e-cigarette smoking, evaporate volatile organic acids or decompose them into free nicotine to compensate for the smoke.
  • the free nicotine is easily oxidized and degraded, and is easily volatile. It has a strong choking sensation and a spicy taste. As the content of free nicotine increases, e-cigarette liquid has poorer throat-passing properties, and consumers may refuse to use it, resulting in "resistance". Although the nicotine salt has good stability and no throat choking, it has a bitter taste, poor taste and irritation. It is difficult to inhale into the brain through the mucous membrane due to poor lipophilicity, and it is difficult to produce physiological satisfaction.
  • the purpose of the present invention is to provide an electronic cigarette that is full of energy, good physiological satisfaction, low or no choking sensation, low or no irritation, good throat passage, and good consumer experience.
  • a solution of nicotine salt (bound nicotine) and a solution of a more alkaline alkali than nicotine both meet in the body, especially in the alveoli, in an atomized state.
  • Can produce free nicotine on site can significantly reduce or eliminate choking sensation, can significantly reduce or eliminate irritation, significantly improve throat, "strength" and physiological satisfaction, and significantly improve consumer experience; at the same time,
  • the content of free nicotine with high volatility in the nicotine solution is greatly reduced or almost zero, which can significantly improve the stability of nicotine and reduce the volatilization of free nicotine from the nicotine solution, which is beneficial to stabilize the nicotine in the nicotine solution Total content.
  • the present invention relates to a kind of (strength and feet, good physiological satisfaction, low or no choking sensation, low or no irritation, good throat passage, high nicotine bioavailability (bioavailability), and good consumer experience )
  • Electronic cigarette (or aerosol generating system/material) characterized in that the electronic cigarette (or aerosol generating system/material) comprises a pharmaceutically acceptable nicotine salt and a pharmaceutically acceptable aerosol or Smoke generating agent composition (I) and containing a pharmaceutically acceptable base stronger than the nicotine (its pKa value is greater than the pKa value of the nicotine) and a pharmaceutically acceptable aerosol or smoke generating agent
  • the composition (II), (the above compositions (I) and (II) are separated from each other and not blended together), the above compositions (I) and (II) (both are aerosolized or vaporized or aerosolized or After being aerosolized), they are inhaled (in the body (especially in the lungs (alveoli))) in aerosolized or
  • the above electronic cigarette also includes a device (kits, device, equipment, unit, etc.) that can aerosolize or vaporize or aerosolize or aerosolize the above compositions (I) and (II). ).
  • composition (I) or (II) is a solid, semi-solid or liquid mixture or solution (at room temperature 25°C), and when the above composition (I) or (II) is solid (at room temperature 25°C), its dosage form It can be powder, granule, tablet (including block, special-shaped tablet), and capsule.
  • compositions (I) and (II) are respectively aerosolized or vaporized or aerosolized or aerosolized by two independent and unconnected atomization subsystems.
  • compositions containing pharmaceutically acceptable nicotine salts of tobacco leaf materials can also be used in the present invention.
  • Nicotine in the present invention means 3-(1-methyl-2-pyrrolidinyl)-pyridine, including synthetic nicotine and nicotine extracts from tobacco plants or parts thereof, such as Nicotiana alone or a combination thereof.
  • the nicotine salt used in the present invention generally refers to a pharmaceutically acceptable salt of nicotine, including its pharmaceutically acceptable inorganic acid salt and organic acid salt.
  • the pKa value of the above acid is lower than the pKa value of nicotine, preferably Low 0.5 or more, more preferably 1 or more, and most preferably 2 or more.
  • the hydrogen on the ring of the molecular structure of the benzene compound is covered by one or more carboxyl groups with carbon atoms of C1 ⁇ C7 (more preferably C1 ⁇ C6) linear or branched (preferably linear predominant) alkane or cycloalkane group, one Or polycarboxyl group or polyhydroxy group with carbon atoms of C2-C7 (preferably C2-C6) linear or branched alkane (preferably straight-chain predominant) hydrocarbon or cycloalkane substituted with the highest carbon atom in the alkane chain in the molecular structure
  • the number of carboxylic acids not higher than C7 preferably C6):
  • anisic acid methoxybenzoic acid
  • o-phenyllactic acid o-phenyllactic acid
  • benzhydryl acid benzoic acid
  • caffeic acid o/or p/or m-methyl salicylic acid
  • salicylic acid acetylsalicylic acid
  • Ferulic acid high oxalic acid (4-Hydroxy-3-methoxybenzeneacetic acid)
  • 4-hydroxyisophthalic acid phenylpropionic acid
  • p-hydroxybenzoic acid isophthalic acid, mandelic acid (mandelic acid), benzene Hexacarboxylic acid, 4,6-dihydroxy-2-methylbenzoic acid (bryoic acid), phenylacetic acid, protocatechuic acid (3,4-dihydroxybenzoic acid), cumene acid (insoluble), gallic acid, 2,5-dihydroxybenzoic acid, 2,5-dihydroxyphenylacetic acid,
  • the hydrogen on the molecular structure of furan compounds, pyran compounds and pyrone compounds is linear or branched (preferably straight chain) by one or more carboxyl groups with carbon atoms of C1 ⁇ C7 (more preferably C1 ⁇ C6) ) Alkane or cycloalkane group, one or more carboxyl group, one or more hydroxyl carbon atoms are C2 ⁇ C7 (more preferably C1 ⁇ C6) linear or branched (preferably straight chain is predominant) alkane or cycloalkane substituted And the highest carbon number of the alkane chain in the molecular structure is not higher than C7 (preferably C6) carboxylic acid:
  • Ascorbic acid dehydroascorbic acid, (6-)deoxy-L-ascorbic acid, glucose-type ascorbic acid, erythorbic acid,
  • organic acids with the highest carbon number of the alkane chain not higher than C7 preferably C6, more preferably straight chain dominant:
  • angelic acid ((Z)-2-methyl-2-butenoic acid), camphor acid (diacid), butylmalonic acid, carboxyglutamic acid (carboxyglutamic acid, polycarboxylic acid), cinnamic acid , Coumaric acid (o/or p/or m-hydroxy benzene acrylic acid), coumaric acid (oxyindene acid, benzofuran carboxylic acid), monoethyl tartaric acid, glucoheptonic acid, glycolic acid, glycyrrhizic acid, Glyoxylic acid hydrate, hydroxyglutamic acid, 1-hydroxy-2-naphthoic acid, 3-hydroxy-2-naphthoic acid, iminodisuccinic acid, indoleacetic acid, isonicotinic acid, 2-keto-L-gu Lonic acid, kojic acid, lactobionic acid, trimethylacetic acid (trimethylacetic acid, pivalic acid, glutaric acid
  • organic acids that are preferably used in the present invention to form nicotine salts with nicotine are malic acid, glycyrrhizic acid, tartaric acid, gluconic acid, oxalic acid, galactonic acid, glucaric acid, glutamic acid, aspartic acid, benzene Formic acid, ascorbic acid, dehydroascorbic acid, (6-)deoxy-L-ascorbic acid, glucose-type ascorbic acid, erythorbic acid. Because they have a better taste, or/and lower irritation or/and higher stability.
  • Hydrochloric acid sulfuric acid, nitric acid, phosphoric acid, pyrosulfuric acid, sulfurous acid, pyrosulfurous acid, thiosulfuric acid, bisulfate, dihydrogen phosphate, bisulfite, benzenesulfonic acid, sulfosalicylic acid.
  • Volatile organic acids are particularly preferred for use in the present invention.
  • Examples of available volatile organic acids are formic acid, acetic acid, benzoic acid, phenylacetic acid, caprylic acid, propionic acid, butyric acid, isobutyric acid, methylbutyric acid, valeric acid, isovaleric acid, methylvaleric acid, caproic acid, Of the isohexanoic acid, benzoic acid, 2-methylbutyric acid, valeric acid, isovaleric acid, 3-methylvaleric acid, phenylacetic acid, isovaleric acid, and caprylic acid are most preferred.
  • nicotine salts are known and can be used, such as CN1607950A, CN101222915A, CN201480025499.X, CN201580038462.5, CN201180028544.3, CN201680079884.1, CN201180022735.9, CN03812809.8, etc. Alkali salt.
  • the preparation method of nicotine salt can also adopt the following simple methods:
  • Acid that can form salt with nicotine Molar ratio of acid:nicotine* Acid that can form salt with nicotine Molar ratio of acid:nicotine*
  • Acid that can form salt with nicotine Molar ratio of acid:nicotine* Formic acid 2:1 Lauric acid 3:1 Acetic acid 3:1 Palmitic acid 3:1 Propionic acid 3:1 tartaric acid 2:1 Butyric acid 3:1 Citric acid 2:1 2-methylbutyric acid 3:1 Malic acid 2:1 3-methylbutyric acid 3:1 oxalic acid 2:1 Valeric acid 3:1 benzoic acid 1:1 Gentisic acid 1:1 Gallic acid 1:1 Phenylacetic acid 3:1 Salicylic acid 1:1 Phthalate 1:1 Picric acid 2:1 Sulfosalicylic acid 1:1 Tannin 1:5 Pectic acid 1:3 Alginic acid 1:2 hydrochloric acid 2:1 Nitric acid 1:1 Benzenesulfonic acid 1:1 Pyruvate 2:1 Glutamate 1:1 Aspartic acid 1:1 sulfuric acid 1:1 Phosphoric acid 1:3
  • the composition (I) may contain a small or trace amount of free nicotine.
  • the amount of free nicotine is less than 10% of the total nicotine (free and bound) in the composition (I), preferably less than 5%, more preferably less than 1%, most preferably less than 0.1%.
  • the content of nicotine salt in the above composition (I) is usually 0.001% to 25% (wt/wt), but can reach 75% (wt/wt) or higher at the highest, preferably 0.01% to 10% ( wt/wt), more preferably 0.1% to 3% (wt/wt), most preferably 0.5% to 2.0% (wt/wt).
  • the above composition (I) When the above composition (I) is in solution (that is, in a solution state), its pH value is usually neutral or acidic, generally 3 to 6.9, preferably 4 to 6.5, more preferably 4 to 6.0, and most preferably 4.5 ⁇ 5.5.
  • the lower pH of the nicotine salt solution increases the irritation of the solution.
  • the higher pH value of the nicotine salt solution increases the amount of free nicotine in the solution, which greatly increases the choking sensation and the irritation. If the pH of the nicotine salt solution is 6.8, only about 10% of the nicotine in the solution is in free form. At a pH of about 8.8, about 90% of the nicotine in the solution is in the free base form.
  • the pH adjuster is selected from hydrochloric acid, sulfuric acid, phosphoric acid, citric acid, lactic acid, tartaric acid, malic acid, metatartaric acid, acetic acid, adipic acid, fumaric acid, sodium hydroxide, sodium carbonate, sodium bicarbonate, potassium carbonate, citric acid One or more of sodium and potassium citrate are mixed.
  • the content of the alkali (more alkaline than the nicotine) in the above composition (II) is usually 0.001% to 25% (wt/wt), but can reach 75% (wt/wt) or higher at the highest , Preferably 0.01% to 10% (wt/wt), more preferably 0.1% to 3% (wt/wt), most preferably 0.5% to 2.0% (wt/wt).
  • the pH value is usually alkaline, generally 7.2-12, preferably 7.5-11, more preferably 8-10, most preferably 8 ⁇ 9.
  • the pharmaceutically acceptable alkali used in the present invention is stronger than the above-mentioned nicotine, and its pKa value is higher than the pKa value of the nicotine, preferably higher than 0.5, more preferably higher than 1, most preferably The height is above 1.5.
  • the pKa value of nicotine is 8.02 (at a temperature of 25°C)
  • the pKa value of the aforementioned alkali is greater than 8.02 (at a temperature of 25°C), preferably greater than 8.5, more preferably greater than 9, and most preferably greater than 9.5
  • the solubility in water or ethanol is usually not less than 10g/kg, preferably not less than 30g/kg, more preferably not less than 50g/kg, and most preferably not less than 100g/kg .
  • Preferred examples of the pharmaceutically acceptable alkalis stronger than the above-mentioned nicotine for use in the present invention are urea, diarno (2-(dimethylamine) ethanol, pKa9.03), tromethamine (three Hydroxymethylmethylamine, pKa8.1), ethanolamine (pKa10.81), diethylethanolamine (pKa about 10), diethanolamine (pKa11.09), triethanolamine (pKa11.01), diethanol monoisopropanol Amine, dihydroxyethyl tert-butanolamine, ethambutol (ethylenediamine dibutanol), isobutanolamine, dipropanolamine, tripropanolamine, triisopropanolamine, diisopropanolamine , Dibutanolamine, Tributanolamine, Diisobutanolamine, Triisobutanolamine, Dipentanolamine, Tripentanolamine, Diisoamy
  • More preferred examples of the pharmaceutically acceptable base used in the present invention that are stronger than the above-mentioned nicotine are amino monosaccharides or disaccharides and methyl or ethylated amino monosaccharides or disaccharides (such as deoxystreptamine , Deoxyglucosamine (e.g. 2-deoxyglucosamine), deoxyglucosamine (e.g.
  • 6-deoxy-D-glucosamine Fucosamine and N-ethyl (or form) acyl-fucose Amine
  • galactosamine such as D-galactosamine
  • reduced glucosamine Glucamine
  • glucosamine glucosamine
  • meglumine pKa9.5
  • meglumine pKa about 9
  • new Mycylamine or N-ethyl (or form) neomycamine
  • trehalosamine diglycosamine
  • the aerosol or aerosol generating agent in the above compositions (I) and (II) means an agent that promotes the formation of aerosol.
  • the aerosol generating agent can promote the formation of aerosol by promoting initial vaporization and/or condensation or sublimation of gas into inhalable solid and/or liquid aerosol.
  • the aerosol generating agent can improve the delivery of flavour from the aerosol generating material.
  • any suitable one or more aerosol generating agents may be included in the above compositions (I) and (II) of the present invention.
  • the suitable aerosol generating agent is selected from pharmaceutically acceptable low boiling point or sublimation point (in the present invention, its definition generally means that the boiling point or sublimation point at 1 atm (1 standard atmosphere) is lower than the temperature of 500°C or 450°C, preferably Ground, 350°C, more preferably 250°C, but not lower than 50°C, preferably not lower than 60°C, more preferably not lower than 70°C, and most preferably not lower than 80°C, the same hereafter, Not otherwise specified), examples of which include, but are not limited to, the following pharmaceutically acceptable additives: low boiling point or sublimation point sugars, such as 1,3-dihydroxyacetone, 1,3-dihydroxyacetone dimer , 2-deoxy-L-ribose, 2-deoxy-D-ribose 2-Deoxy-D-ribose, arabinose, erythrose, ery
  • Fatty alcohol esters such as triethyl citrate, diethyl malate, diethyl succinate), dodecenyl acetate, benzyl benzoate, phenethyl phenylacetate, ethyl vanillate, propylene carbonate Esters); water; or mixtures thereof.
  • aerosol generating agents include, but are not limited to: sorbitol, xylitol, glycerin, ethanol, fatty acid esters with C1 to C4 glycerol atoms, fatty acid esters with C1 to C4 propylene glycol, and poly Glycerin, polypropylene glycol, C2-C6 polybasic acid fatty alcohol esters with C1-C4 atoms, propylene carbonate, and mixtures thereof, such as ethanol, glycerin, propylene glycol, triethylene glycol, butylene glycol (1 ,2-butanediol, 1,3-butanediol, 1,4-butanediol), 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1, 2-Caprylyl glycol, glycerol triacetate, glycerol diacetate formate, glycerol diacetate
  • the solvent is usually a liquid aerosol generator (at a temperature of 25°C), such as water, ethanol, aliphatic polyols of C3 to C8, and glycerin.
  • C1-C8 fatty acid esters propylene glycol fatty acid esters with C1-C8 atoms, polyglycerol, polypropylene glycol, C2-C6 polybasic acid fatty alcohol esters with C1-C4 atoms, propylene carbonate, And mixtures thereof, such as water, ethanol, glycerin, propylene glycol, triethylene glycol, butanediol (1,2-butanediol, 1,3-butanediol, 1,4-butanediol), 1,2 -Pentylene glycol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, glycerol triacetate, glycerol diacetate formate, glycerol diacetate, glycerin Diacetate propionate, glycerol tripropionate, polydi-hexaglycerin, polydi-hex
  • compositions (I) and (II) may include other additives.
  • Other additives can optionally be added to it.
  • Optional additives include one or more stabilizing additives, such as antioxidants, including vitamin E, namely tocopherol, vitamin C, namely ascorbic acid and its salts, sodium metabisulfite, butylated hydroxytoluene, butylated hydroxyanisole ; And preservatives, including parabens, benzalkonium chloride, chlorobutanol, benzyl alcohol, ⁇ -phenylglydol, cetylpyridinium chloride; galate, such as Propyl gallate.
  • stabilizing additives such as antioxidants, including vitamin E, namely tocopherol, vitamin C, namely ascorbic acid and its salts, sodium metabisulfite, butylated hydroxytoluene, butylated hydroxyanisole ;
  • preservatives including parabens, benzalkonium chloride, chlorobutanol, benzyl alcohol, ⁇ -phenylglydol, cetylpyridin
  • additives include one or more additives selected from:
  • -Enhancers penetration enhancers
  • azone such as azone
  • vitamin C and E such as vitamin C and E
  • -minerals such as fluoride, especially sodium fluoride, sodium monofluorophosphate and stannous fluoride
  • -Deodorants such as zinc and cyclodextrin
  • -Propellants such as optionally liquefied 1,1,2,2-tetrafluoroethane (HFC-134a) and optionally liquefied 1,1,1,2,3,3,3-heptafluoropropane (HFC -227);-Thickeners (viscosity modifiers), such as polysaccharide compounds.
  • -Sweeteners including one or more synthetic sweeteners and/or natural sugars, for example selected from artificial sweeteners, such as saccharin and its sodium and calcium salts, aspartame, acesulfame and its potassium Salt, thaumatin and licorice sweetness;
  • artificial sweeteners such as saccharin and its sodium and calcium salts, aspartame, acesulfame and its potassium Salt, thaumatin and licorice sweetness
  • -Polyols such as sorbitol, xylitol, mannitol and glycerol; monosaccharides, including glucose (also known as dextrose), fructose (also known as levose) and galactose;
  • sucrose also known as sucrose
  • lactose also known as milk sugar
  • maltose also known as malt sugar
  • liquid glucose syrups such as starch hydrolysates mainly containing a mixture of dextrose, maltose, dextrin and water, invert sugar syrups, such as sucrose converted by invertase containing dextrose, fructose and water , High-sugar syrups, such as molasses, honey and malt extract; and mixtures thereof.
  • -Flavoring and/or aromatic agents such as essential oils obtained by distillation, solvent extraction or cold pressing of fresh or dried flowers, buds, leaves, stems, fruits, seeds, peel, bark or roots, such as peppermint, spearmint, Eucalyptus, holly, niaouli, cloves, cardamom, cinnamon, bitter almonds, coriander, fennel, ginger, juniper, orange, bitter orange, lemon grapefruit, citrus, bergamot, thyme, anise, and rosemary Fragrant oil
  • fragrances including flavoring groups naturally derived from fruits, berries, pits, spices, mint, tobacco, cocoa, coffee, tea, vanilla, licorice, caramel, taffy, honey, wine, distilled spirits and beer Diluted liquid of essential oil or concentrate;
  • -Synthetic flavors and fragrances consisting of: mixed to match, for example, fruits, berries, stones, spices, mint, tobacco, cocoa, coffee, tea, vanilla, licorice, caramel, taffy, honey, wine, distilled spirits Or a mixture of chemical substances in the natural flavor of beer including hydrocarbons, alcohols, aldehydes, esters, ketones, ethers and oxides;
  • the amount (weight) ratio between the above compositions (I) and (II) is not limited, usually 1:100-100:1 (wt/wt), preferably 1:10-10:1 (wt/wt) ), more preferably 1:3 to 3:1 (wt/wt), most preferably 1:1.5 to 1.5:1 (wt/wt).
  • compositions (I) and (II) can be added in any suitable order and mixed until they are uniform.
  • compositions (I) and (II) are in liquid form, they can be divided into cartridges or containers with larger volumes, and then added to smoking sets when used later.
  • compositions (I) and (II) are in a solid state, they are mixed until they are uniform and then processed into powders, granules or tablets, which can be divided into cartridges, or directly added to smoking sets when used later.
  • low boiling point or sublimation point used in the present invention generally means that the boiling point or sublimation point at 1 atm is lower than the temperature 500°C or 450°C, preferably 350°C, more preferably 250°C, but not lower than 50°C. It is preferably not lower than 60°C, more preferably not lower than 70°C, and most preferably not lower than 80°C.
  • pharmaceutically acceptable refers to a material that is not biologically or otherwise undesirable, that is, the material can be administered to a (biological) individual, such as a human, without causing any excessive undesirable in the individual Such as toxic biological effects, or will not have excessive harmful interactions with any components in the composition containing it.
  • additive refers to one or more biologically active ingredient carriers that can be mixed with each other without interaction without reducing the stability and/or biological activity of the biologically active ingredient carrier and are suitable for topical use. Or supplementary materials for systemic administration of biologically active ingredients.
  • the term "about” used in the present invention means that the index value varies within ⁇ 30%, preferably within ⁇ 20%, within ⁇ 10%, most preferably within ⁇ 5%, such as about 10, then Represents 7-13, preferably 8-12, more preferably 9-11, most preferably 9.5-10.5.
  • one type used in the present invention means to include at least one type, which may be one type, two types or more.
  • soluble used in the present invention means that the solubility of a substance in 100 ml of solvent such as water at a temperature of 25°C is not less than 5 g, preferably 10 to 30 g.
  • the electronic cigarette (or aerosol generating system/material) product of the present invention can be used for treatment.
  • the treatment can be selected from the group consisting of reducing the use of tobacco, stopping the use of tobacco, other tobacco use, temporary abstaining from abstaining from use of tobacco, Alzheimer’s disease, Crohn’s disease, Pa Disease or medical indications and weight control of Kingson’s disease, Tourette’s syndrome and ulcerative colitis.
  • a device used for aerosolization or vaporization or aerosolization or aerosolization of an electronic cigarette (or aerosol generating system/material) (above), which includes two independent and unconnected devices
  • the atomization subsystem (aerosolization or vaporization or aerosolization or aerosolization of the above composition (I) and (II) (or two different aerosol-generating materials) respectively), the atomization subsystems respectively include A liquid storage chamber/or accommodating cavity (and its constituent parts), an atomization chamber (and its constituent parts), a mist or smoke channel (and its constituent parts) or guide 1 and the atomizing component or
  • An aerosol-generating component the liquid storage chamber/or accommodating cavity is directly connected to the atomization chamber or is communicated through a guide member 2, one end of the mist or smoke channel or guide member 1 is in communication with the atomization chamber, and the other end is respectively It communicates with a suction (nozzle) hole, or the other end of the above two mist or smoke channels or guides 1 is
  • the above-mentioned atomization chamber can be a hollow continuous cavity or a discontinuous cavity, such as the micropores in a material with many micropores (such as non-woven fabrics with many micropores, ceramics, glass, metal, plastics)
  • the above-mentioned guide 2 can be a material containing fine pores (such as non-woven fabric, ceramic, glass, metal, plastic containing fine pores), or a hollow introduction tube;
  • the above-mentioned atomization component includes heating type (such as resistance heating type or electromagnetic (oscillation) heating type) or/and vibration type (such as ultrasonic vibration type) or/and compression type atomization assembly.
  • a resistance heating type component is applied.
  • the heating element can be in the form of a wire mesh, a coil, or multiple wires.
  • the heating element may comprise metal or metal alloy.
  • Metal is an excellent conductor of electricity and heat. Suitable metals include, but are not limited to: copper, aluminum, platinum, tungsten, gold, silver, and titanium. Suitable metal alloys include, but are not limited to: nickel-chromium alloys and stainless steel.
  • the aforementioned liquid storage chamber/or containing cavity may be in direct or indirect contact with the liquid, for example, the aforementioned liquid storage room/or containing cavity contains another container such as a cigarette cartridge containing the liquid.
  • the device used in the present invention also includes a housing, a power supply assembly, and necessary accessories. Further, it can also include cartridges, control components, and (pneumatic) switch components.
  • the casing is provided with a cigarette holder and a vent hole, the suction (mouth) hole is located in the cigarette holder, the vent hole communicates with the air inlet of the atomization chamber, and the outlet hole of the atomization chamber is connected to the mist or smoke channel Or the guide 1 is connected.
  • the inner wall of the pharyngeal mouth is provided with multi-level (annular) accommodating cavities, which can prevent the user from not inhaling the e-liquid when smoking the mouthpiece, so that the smoker has a better taste.
  • the inner port of the aforementioned air inlet and/or outlet in the atomization cavity is provided with a hole wall protruding from the inner wall of the atomization cavity, so that the smoke oil condensed in the atomization cavity will not directly flow out of the outlet hole It is sucked into the mouth by the user, so that the smoker obtains a better taste, and/or prevents the e-cigarette from flowing out from the air inlet and vent holes to contaminate the internal or external surface of the electronic cigarette.
  • the above-mentioned device for aerosolization or vaporization or aerosolization or aerosolization of an electronic cigarette (or aerosol generating system/material) can be configured to aerosol-generating material (the above composition (I) and ( II)) Heat to a temperature of about 50-500 or 450°C, 100-350°C, 150-350°C, 150-330°C or 180-300°C.
  • Examples of preferred devices used in the present invention are:
  • One independent ultrasonic atomizer or compressed atomizer or net atomizer has two atomizer outlets and another independent ultrasonic atomizer or compressed atomizer or net atomizer.
  • An independent and unconnected catheter is connected, the other end of the catheter is connected to two branch pipes of a tee, and the other end of the tee is connected to an inhalation mask that can be placed on the nose and mouth.
  • the mist or smoke in the inhalation mask can be inhaled through the inhalation mask through the nasal cavity or/and the oral cavity.
  • the above-mentioned three links are spaced apart from one end of the branch pipe communicating with the inhalation mask that can be placed on the nose and mouth.
  • An ultrasonic atomizer, compressed atomizer or mesh atomizer includes 2 independent and unconnected atomization subsystems, and the mist outlets of the atomization subsystem are respectively connected by two independent unconnected ducts.
  • the other end of the catheter is connected with two branch pipes in a tee, and the branch pipe at the other end of the tee is connected with an inhalation mask that can cover the nose and mouth, or one (preferably, The tube separated from each other) is connected to an inhalation mask that can be placed on the nose and mouth, through which the user can inhale the mist or smoke in the inhalation mask through the nasal cavity or/and oral cavity.
  • the above-mentioned three links are spaced apart from one end of the branch pipe communicating with the inhalation mask that can be placed on the nose and mouth.
  • Two e-cigarettes with independent atomization systems are combined for direct oral inhalation together, or after the combination, their mist outlets are respectively connected to two independent and unconnected catheters (such as rubber tubes, silicone tubes) for oral inhalation, Or the other ends of the two independent and unconnected catheters are connected with two branch pipes in a tee, and the branch pipe at the other end of the tee is connected with a catheter that can be used for oral inhalation.
  • the outer diameter of the aforementioned catheter is usually 3mm-12mm, preferably 4mm-6mm.
  • the catheter has a large end and a small end, the larger outer diameter is 8mm-12mm, the outer diameter is 2mm-5mm, and the smaller end is used for the mouth.
  • Example 4 an electronic cigarette device that includes 2 independent and unconnected atomization subsystems (a device for the aerosolization or vaporization or aerosolization or aerosolization of the above-mentioned electronic cigarette (or aerosol generating system/material) (kits, device, equipment, unit)), such as:
  • An electronic cigarette (a device) (a device (kits, device, equipment, unit) used for the aerosolization or vaporization or aerosolization or aerosolization of the electronic cigarette (or aerosol generating system/material) mentioned above), It includes a cigarette-shaped cavity housing (4), a power supply (2), a cigarette cartridge (3) and a cigarette stick accessory.
  • the housing is sequentially provided with the power supply (2), one Pneumatic switch (7), high-frequency generator (8), a magnetostrictive vibrator (9) and an electromagnetic induction heater (liquid storage chamber/or accommodating chamber) separated by two non-communicating chambers ( 10) or said a pneumatic switch (7), a power supply (2), a high-frequency generator (8), a magnetostrictive vibrator (9) and two chambers (liquid storage The electromagnetic induction heater (10) of the chamber/or containing cavity), wherein the high-frequency generator (8) is connected to the magnetostrictive vibrator (9) and the electromagnetic induction heater (10) through wires.
  • pneumatic switch (7) Connect with pneumatic switch (7);
  • a light emitting diode (6) is provided at the front end of the housing (4), which is respectively connected to the pneumatic switch (7) and the power source (2) through wires;
  • the rear end of the shell (4) is connected with the cartridge (3), and two compartments (liquid storage chamber/or containing Cavity) (31);
  • the vapor or smoke channels in the electronic cigarette are spaced apart and not communicated with each other. (As shown in Figure 1-1 and 3)
  • the above electronic cigarette further includes a cigarette cap (1), which is arranged at the front end of the light emitting diode (6) and covers the light emitting diode (6) inside.
  • the power source (2) described in the above electronic cigarette is a rechargeable battery, which has a charging positive electrode contact point (21) and a negative electrode contact point (22).
  • the magnetostrictive vibrator (9) described in the above electronic cigarette includes: a magnetostrictive rod (93) with a permanent magnet (91) provided at both ends of the magnetostrictive vibrator.
  • a drive coil (92) is wound on the outside of the telescopic rod (93) and the two permanent magnets (91), and a vibration sensor (94) is arranged on the permanent magnet (91) and the electromagnetic induction heater ( 10) Between. (As shown in Figure 1-2)
  • the electromagnetic induction heater (10) described in the above electronic cigarette includes: a vibrating plate (101) is fixedly connected to the housing (4) by an external thread thereon, and the lower part is correspondingly provided with A stainless steel tube (104) with two cavities (liquid storage chamber/or accommodating cavity) spaced apart from each other, and inside the two cavities (liquid storage chamber/or accommodating cavity) of the stainless steel tube (104) Nickel mesh wires (103) are respectively installed, and an induction coil (102) is arranged between the stainless steel tube (104) and the housing (4). (As shown in Figure 1-2)
  • the pneumatic switch (7) described in the above electronic cigarette includes: an upper clip body (71) and a lower clip body (74) butted together, wherein the upper clip body (71) And the butt joints of the lower clip body (74) are respectively provided with grooves, and the outer edge of a silicone bladder (73) is arranged in the grooves, and the silicone bladder (73) has a central hole and a magnet (72) Installed in the central hole of the silicone bladder (73), the lower clip body (74) is provided with a vent hole, the upper clip body (71) is provided with a circuit board, the upper clip body (71) and the outer side of the lower clamp body (74) are provided with wire grooves for placing the wires of the circuit board. (As shown in Figure 1-4)
  • the silicone bladder (73) in the electronic cigarette is provided with air slits or pores.
  • the circuit board described in the electronic cigarette is provided with a human body clutter sensor (75), a data processor (76), a master control output circuit (77), and an amplified output circuit connected in series in sequence. (78) and an over-temperature, over-current and over-discharge protection circuit (79), wherein the amplifying output circuit (78) and over-temperature, over-current and over-discharge protection circuit (79) are connected to an ultrasonic atomizer (70) . (As shown in Figure 1-5)
  • the cartridge (3) described in the above electronic cigarette includes a casing (33) on which a positioning boss (35) is provided, and the casing is sequentially arranged with spaced apart and non-communicating The bayonet (32), the two smoke liquid return chambers (34) which are separated and not communicated, and the two liquid storage chambers/or the containing chambers (31) which are separated and not communicated.
  • the outer end of the housing (33) is provided There is a cotton screen (36) which is separated and is not connected to prevent the smoke liquid from being sucked into the mouth of the user. (As shown in Figure 1-6)
  • An electronic cigarette (a device) (a device (kits, device, equipment, unit) used for the aerosolization or vaporization or aerosolization or aerosolization of the electronic cigarette (or aerosol generating system/material) mentioned above), It is characterized in that the device includes an outer casing, a cigarette holder, necessary accessories and an ultrasonic atomization device; the outer casing and the cigarette holder have two isolated and unconnected mist or smoke channels, one end of which is communicated with the air outlet on the cigarette holder, The other end is communicated with the aerosol outlet in the above-mentioned ultrasonic atomization device; the ultrasonic atomization device includes an inner casing (10), a power supply (12), a liquid storage part (liquid storage chamber/or accommodation cavity) (14), A mesh member (20) and a vibration source (30), a liquid storage portion (liquid storage chamber/or accommodation cavity) (14) is formed in the housing (10), and the liquid storage portion (liquid storage chamber/or The accommodating cavity) (14) (middle) is separated
  • the mesh member (20) is embedded at the outlet of the aerosol, and the mesh member (20) has a plurality of fine holes (21).
  • Porous mesh structure the vibration source (30) is connected to the mesh member (20), the vibration source (30) is electrically connected to the power source (12), and the vibration source (30) can be Generate vibrations and drive the mesh member (20) to vibrate to vibrate and atomize the liquid near the mesh member (20); the fine holes (21) penetrate the mesh member (20) to make the liquid mist
  • the transformed smoke can flow out along the micropores 21, the mesh member (20) is electrically connected to the power source (12), and the mesh member (20) can generate heat after being energized and cause the mesh member ( 20)
  • the nearby liquid is heated and atomized.
  • the vibration source (30) is at least partially located in the liquid storage portion (14), and the end surface of one end of the vibration source (30) is in contact with the mesh The member (20) is connected.
  • the vibration source (30) is located between the power source (12) and the liquid storage portion (14), and one end of the vibration source (30) extends into Inside the liquid storage part (14).
  • the ultrasonic atomization device wherein the ultrasonic atomization device is used for electronic cigarettes, and the housing (10) is provided with a partition (18) hermetically connected with the housing (10) , The partition (18) seals and forms the bottom of the liquid storage portion (14), and one end of the vibration source (30) passes upwards through the partition (18) and extends into the liquid storage portion (14). )Inside.
  • a cover (24) is provided between the periphery of the mesh member (20) and the aerosol outlet of the liquid storage portion (14), and the mesh member (20) It is sealed with the housing (10) by the cover liner (24), and the periphery of the mesh member (20) abuts against the cover liner (24), so that the mesh member (20) can be kept in place even when vibrated Inside the cover lining (24).
  • the longitudinal section of the liquid storage portion (14) is in a concave shape, and the center of the liquid storage portion (liquid storage chamber/or accommodation cavity) (14) is formed (middle ) Isolate the two aerosol channels (16) that are not communicating with each other.
  • One end of the micropores (21) of the mesh member (20) is in communication with the liquid storage portion (14), and the other end is connected with the aerosol channel ( 16) Connectivity.
  • the mesh member (20) is a flat plate structure, and the fine holes (21) of the mesh member (20) are arranged in a honeycomb shape through the ribs (23).
  • the micropore (21) has a large pore diameter at both ends and a small middle pore diameter, or the micropore (21) has a large pore diameter at one end and a small pore diameter at the other end, wherein when the micropore (21) has a diameter at one end Larger and smaller pore size at the other end, the end with larger pore size is the liquid inlet end communicating with the inside of the liquid storage part (14), and the end with the smaller pore size is the aerosol outlet end.
  • the mesh member (20) further includes a metal mesh
  • the metal mesh includes two layers, which are the top metal mesh and the metal mesh on the top of the mesh member (20).
  • the bottom metal mesh is arranged at the bottom of the mesh member (20), and the ribs (23) are arranged at intervals between the bottom metal mesh and the top metal mesh, and are electrically connected to the bottom metal mesh and the top metal mesh.
  • the mesh member (20) is made of conductive anti-corrosion material.
  • An integrated electronic cigarette (set) with an oil cup (a type of electronic cigarette (or aerosol generating system/material) used for aerosolization or vaporization or aerosolization or aerosolization of the above electronic cigarette (or aerosol generating system/material) with an oil cup
  • a device including a housing (1) and a control component (2), a battery (3) and an atomizer (4) arranged in the housing (1), the control component (2) Electrically connected to the heating wire (41) of the battery (3) and the atomizer (4), characterized in that: the casing (1) is also provided with an oil cup (storage) for containing smoke liquid
  • the liquid chamber/or containing cavity) (5), the atomizer (4) and the oil cup (liquid storage chamber/or containing cavity) (5) are arranged adjacently, and the oil cup (5) is adjacent to the atomizer ( 4)
  • One end is provided with an e-liquid outlet (51), and the e-liquid outlet (51) is packaged with a material with micropores (such as non-woven fabric
  • the caliber of the e-liquid outlet (51) in the electronic cigarette is the same as the caliber of the oil cup (5).
  • one end of the housing (1) in the above-mentioned electronic cigarette is provided with (in the middle) two channels which are not connected to each other but smoke can pass through respectively, and the above-mentioned channel openings (ie nozzle holes) are provided.
  • the cigarette holder cover (11) of the housing (1) is provided with a lamp cover (12) with an LED lamp at the other end of the housing (1), the control assembly (2) is fixed in the lamp cover (12), and the control assembly (2) Including control circuit board and control switch.
  • a first air inlet (121) is provided on the side of the lamp cover (12) in the above electronic cigarette, and the control switch of the control assembly (2) is an inhalation automatic switch.
  • the atomizer (4) in the above-mentioned electronic cigarette includes an oil-separating silicone seat (42) and a (middle) isolation connecting pipe (43) through which the smoke is not communicated with each other.
  • the oil silicone seat (42) is in interference fit with the housing (1), one end of the connecting pipe (43) is in contact with the grease-proof silicone seat (42), and the other end of the connecting pipe (43) is in contact with the smoke liquid
  • a glass fiber rope (44) is respectively arranged on the two cavities separated by the connecting pipe (43), and the heating wire (41) ) Is wound around the glass fiber rope (44), and the oil-separating silicone seat (42) is provided with two air inlets (or (in the middle) isolation and non-communication) (421) separately isolated from the connecting pipe (43)
  • the two chambers are communicated, and the air holes (421) are respectively communicated with the first air inlet hole (121) and a suction nozzle hole on the
  • An electronic cigarette device (a device used for the aerosolization or vaporization or aerosolization or aerosolization of the above-mentioned electronic cigarette (or aerosol generating system/material) (kits, device, equipment, unit) ), the device (/smoker) includes (upper and lower) housings, power supply components, necessary accessories and 2 independent and unconnected atomization subsystems; the lower housing (which is a rectangular parallelepiped) contains power supply components, Atomization subsystem, two isolated and incommunicable mist or smoke channels, one end of the mist or smoke channel is in communication with the above-mentioned atomization subsystem, and the other end is in communication with the mist or smoke channel in the upper casing described below;
  • the upper shell is a cigarette holder, which (in the shape of two oblique sides (preferably arc-shaped),) the long side is connected to the lower shell, and the short side has two air outlets (the trapezoidal body), which has One end of the two isolated and incommunicable mis
  • the edges (/sides) or/and corners of the upper shell and the lower shell are rounded.
  • the suction end of the mouthpiece of the upper shell is extended to meet the needs of smoking.
  • the above-mentioned upper shell mouthpiece extension may be in a shape of a cylinder, square prism, prismatic, or hammer without being limited to science.
  • the above-mentioned independent atomization subsystems respectively include a liquid storage chamber/or accommodating cavity (and its constituent parts), an atomization chamber (and its constituent parts), a mist or smoke channel (and its constituent parts) or guide member 1
  • the atomization component, the liquid storage chamber/or the accommodating cavity and the atomization chamber are directly communicated or communicated through the guide member 2, and the mist or smoke channel or the guide member 1 is the mist in the upper and lower shells.
  • Vapor or smoke channel, the isolation between the two liquid storage chambers/or containing chambers is not connected, the isolation between the two atomization chambers is not connected, the isolation between the two guides 2 is not connected, the two vapor or smoke channels or the guide 1 The isolation is not connected.
  • compositions (I) and (II) are respectively placed in the two isolated and unconnected liquid storage chambers/or accommodating chambers (or chambers), or the above-mentioned compositions (I) and (II) are respectively preset in The glass, ceramic, metal and other containers are placed together with the above-mentioned container in the above-mentioned two isolated liquid storage chambers/or containing chambers (or chambers).
  • this product can better deliver or "promote” nicotine, and better provide a positive recipient nicotine effect
  • the performance is relatively smooth and supple when used, the throat and/or oral properties are good, the user is not easy to produce "resistance", the satisfaction and comfort are better, the choking sensation is low, and the irritation is less;
  • the present invention almost inherits all the advantages of nicotine salt and free nicotine, and almost overcomes all the disadvantages of nicotine salt and free nicotine.
  • Figure 1-1 is a structural diagram of example 4-1 of electronic cigarettes
  • Figure 1-2 is a schematic diagram of the structure of the magnetostrictive ultrasonic vibrator and electromagnetic induction heater of e-cigarette example 4-1;
  • Figure 1-3 is a schematic diagram of the control circuit of the electronic cigarette example 4-1;
  • Figure 1-4 is a schematic diagram of the pneumatic switch structure of the electronic cigarette example 4-1;
  • Figure 1-5 is a schematic diagram of the theme structure of the circuit board of the electronic cigarette example 4-1;
  • Figure 1-6 is a schematic diagram of the structure of the electronic cigarette case 4-1 cartridge.
  • Figure 2-1 is a schematic diagram of the structure of the ultrasonic atomization device in Example 4-2 of the electronic cigarette;
  • Figure 2-2 is the working flow chart of the ultrasonic atomization device in Example 4-2 of the electronic cigarette.
  • Figure 3-1 is a schematic cross-sectional structure diagram of Example 4-3 of the electronic cigarette.
  • Nicotine salt solution nicotine maleate, concentration: 0.08%, solvent: water and butanediol (volume ratio 9:1), pH value: 5.2, (add to) total: 100ml;
  • Alkaline solution potassium leucine, concentration: 12.5%, solvent: water, total amount: 100 ml.
  • Atomization device The mist outlet of an independent ultrasonic atomizer and the mist outlet of another independent ultrasonic atomizer are respectively connected by two independent and unconnected pipes.
  • the other end of the pipe is connected to the The two branch pipes are connected, and the branch pipe at the other end of the tee is connected with an inhalation mask that can be placed on the nose and mouth.
  • the user can inhale the mist in the inhalation mask through the nasal cavity or/and oral cavity through the inhalation mask
  • the above-mentioned three links are spaced apart and not communicated with one end of the branch pipe that communicates with the inhalation mask that can be placed on the nose and mouth.
  • the above-mentioned ultrasonic atomizer is Yuehua ultrasonic atomizer (model: WH-2000), and the atomization speed is about 2ml/min.
  • Nicotine salt solution galactose diacid nicotine salt, concentration: 1.5%, solvent: water and ethanol (volume ratio 8:2), pH value: 3.2, (add to) total: 100ml;
  • Alkaline solution fucosamine, concentration: 4.5%, solvent: water and glycerin (volume ratio 8:2), (add to) total amount: 100ml.
  • Atomization device The mist outlet of an independent compression atomizer and the mist outlet of another independent compression atomizer are respectively connected by two independent unconnected pipes, and the other end of the pipe is connected with a three-way
  • the two branch pipes in the three links are connected, and the branch pipe at the other end of the tee is connected with an inhalation mask that can be placed on the nose and mouth.
  • the user can inhale the inhalation mask through the nasal cavity or/and oral cavity
  • the above-mentioned three links are separated from one end of the branch pipe that communicates with the inhalation mask that can be placed on the nose and mouth.
  • the above-mentioned ultrasonic atomizer is: a fish-leap compression atomizer (model: 403H), and the atomization speed is about 0.25 ml/min.
  • Nicotine salt solution nicotine malate, concentration: 0.5%, solvent: water and propylene glycol (volume ratio 7:3), pH value: 5.6, (add to) total: 100ml;
  • Alkaline solution sodium ornithine, concentration: 17.5%, solvent: water, total amount: 100 ml.
  • Atomization device The mist outlet of an independent compression atomizer and the mist outlet of another independent compression atomizer are respectively connected by two independent unconnected pipes, and the other end of the pipe is connected with a three-way
  • the two branch pipes in the three links are connected, and the branch pipe at the other end of the tee is connected with an inhalation mask that can be placed on the nose and mouth.
  • the user can inhale the inhalation mask through the nasal cavity or/and oral cavity
  • the above-mentioned three links are separated from one end of the branch pipe that communicates with the inhalation mask that can be placed on the nose and mouth.
  • the above-mentioned ultrasonic atomizer is: Omron compression atomizer (model: NE-C25S), and the atomization speed is about 0.25 ml/min.
  • Nicotine salt solution nicotine oxalate, concentration: 0.7%, solvent: water and glycerin (volume ratio 7.5: 2.5), pH value: 6.2, (add to) total: 100ml;
  • Alkaline solution sodium propionate water, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 6:4), (add to) total amount: 100ml.
  • Atomization device The mist outlet of an independent compression atomizer and the mist outlet of another independent compression atomizer are respectively connected by two independent unconnected pipes, and the other end of the pipe is connected with a three-way
  • the two branch pipes in the three links are connected, and the branch pipe at the other end of the tee is connected with an inhalation mask that can be placed on the nose and mouth.
  • the user can inhale the inhalation mask through the nasal cavity or/and oral cavity
  • the above-mentioned three links are separated from one end of the branch pipe that communicates with the inhalation mask that can be placed on the nose and mouth.
  • the above-mentioned ultrasonic atomizer is an Omron compression atomizer (model: NE-C28), and the atomization speed is about 0.25 ml/min.
  • Nicotine salt solution succinic acid (succinic acid) nicotine salt, concentration: 3.5%, solvent: water and glycerol acetate (volume ratio 9:1), pH value: 5.2, (add to) total: 100ml ;
  • Alkaline solution calcium gluconate, concentration: 0.5%, solvent: water and glycerin (volume ratio 7:3), (add to) total amount: 100ml.
  • Atomization device The mist outlet of an independent net atomizer and the mist outlet of another independent net atomizer are respectively connected by two independent and unconnected pipes, and the other end of the pipe is connected to a tee
  • the two branch pipes in the three links are connected, and the branch pipe at the other end of the tee is connected with an inhalation mask that can be placed on the nose and mouth.
  • the user can inhale the inhalation mask through the nasal cavity or/and oral cavity
  • the above-mentioned three links are separated from one end of the branch pipe that communicates with the inhalation mask that can be placed on the nose and mouth.
  • the above-mentioned ultrasonic atomizer is a fish-leap-net atomizer (model: M-102 or HL100A), and the atomization speed is about 0.2ml/min.
  • Nicotine salt solution nicotine salt of ketoglutarate, concentration: 4.5%, solvent: water and polyethylene glycol (volume ratio 8.5: 1.5), pH value: 4.5, (add to) total: 100ml;
  • Alkaline solution sodium pyrophosphate, concentration: 1.5%, solvent: water and butanediol (volume ratio 9.5:0.5), (add to) total amount: 100ml.
  • Atomization device The mist outlet of an independent compression atomizer and the mist outlet of another independent compression atomizer are respectively connected by two independent unconnected pipes, and the other end of the pipe is connected with a three-way
  • the two branch pipes in the three links are connected, and the branch pipe at the other end of the tee is connected with an inhalation mask that can be placed on the nose and mouth.
  • the user can inhale the inhalation mask through the nasal cavity or/and oral cavity
  • the above-mentioned three links are separated from one end of the branch pipe that communicates with the inhalation mask that can be placed on the nose and mouth.
  • the above-mentioned ultrasonic atomizer is a Philips compressed atomizer (model: CN-B-0103), and the atomization speed is about 0.2ml/min.
  • Nicotine salt solution nicotine citrate, concentration: 1.5%, solvent: water and glycerol triacetate (volume ratio 8.5: 1.5), pH value: 5.3, (add to) total: 10ml;
  • Alkaline solution sodium hydrogen phosphate, concentration: 0.8%, solvent: water and propylene glycol (volume ratio 8.5: 1.5), (add to) total amount: 1000 ml.
  • Atomization device The mist outlet of an independent net atomizer and the mist outlet of another independent net atomizer are respectively connected by two independent and unconnected pipes, and the other end of the pipe is connected to a tee
  • the two branch pipes in the three links are connected, and the branch pipe at the other end of the tee is connected with an inhalation mask that can be placed on the nose and mouth.
  • the user can inhale the inhalation mask through the nasal cavity or/and oral cavity
  • the above-mentioned three links are separated from one end of the branch pipe that communicates with the inhalation mask that can be placed on the nose and mouth.
  • the above-mentioned ultrasonic atomizer is a Raffles mesh atomizer (model: mini air 360+), and the atomization speed is about 0.8ml/min.
  • Nicotine salt solution nicotine tartrate, concentration: 2.5%, solvent: water, propylene glycol, polydiglycerol (volume ratio 1.5:6.5:2), pH value: 6.5, (add to) total: 100ml;
  • Alkaline solution sodium carbonate, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (add to) total amount: 100ml.
  • Atomization device Two identical independent e-cigarettes are connected by two independent and incommunicable tubes (such as rubber tubes, silicone tubes) of different sizes at both ends, and combined for oral inhalation, the larger of the above-mentioned tubes One end is connected to the smoke outlet of the smoking device, the smaller end is used for oral inhalation, and the outer diameter of the smaller end is 3mm-4mm.
  • the electronic smoking set is the smoking set disclosed in the invention patent CN201410223508.8 or a commercially available electronic smoking set (such as MOTI brand, TENSO brand, Huali door brand, HOPESON brand, the same hereafter).
  • Nicotine salt solution nicotine acetate, concentration: 2.5%, solvent: water and propylene carbonate (volume ratio 1.5:8.5), pH value: 5.5, (add to) total: 100ml;
  • Alkaline solution sodium phosphate, concentration: 1.2%, solvent: water and propyl glycerol diacetate (volume ratio 1.5:8.5), (add to) total amount: 100ml.
  • Atomization device Two identical independent e-cigarettes are connected by two independent and incommunicable tubes (such as rubber tubes, silicone tubes) of different sizes at both ends, and combined for oral inhalation, the larger of the above-mentioned tubes One end is connected to the smoke outlet of the smoking set, and the smaller end is used for oral inhalation, and the outer diameter of the smaller end is 3mm-4mm.
  • the electronic smoking set is the smoking set disclosed in the invention patent CN201410371441.2 or a commercially available electronic smoking set.
  • Nicotine salt solution nicotine butyrate salt, concentration: 0.5%, solvent: water, propylene glycol, triacetin (volume ratio 1.5:6.5:2), pH value: 5.2, (add to) total: 1000ml ;
  • Alkaline solution trisodium glycyrrhizinate, concentration: 0.5%, solvent: water, propylene glycol, glycerin (volume ratio 1:7.5:1.5), (add to) total amount: 10ml.
  • Atomization device Two identical independent e-cigarettes are connected by two independent and incommunicable tubes (such as rubber tubes, silicone tubes) of different sizes at both ends, and combined for oral inhalation, the larger of the above-mentioned tubes One end is connected to the smoke outlet of the smoking set, and the smaller end is used for oral inhalation, and the outer diameter of the smaller end is 3mm-4mm.
  • the electronic smoking set is the smoking set disclosed in the utility model patent CN201320043282.4 or a commercially available electronic smoking set.
  • Nicotine salt solution nicotine lactate, concentration: 2.5%, solvent: water, propylene glycol, polytriglycerol (volume ratio 1:7:2), pH value: 4.2, (add to) total: 100ml;
  • Alkaline solution sodium saccharin, concentration: 2.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (add to) total amount: 100ml.
  • Atomization device Two identical independent e-cigarettes are connected by two independent and incommunicable tubes (such as rubber tubes, silicone tubes) of different sizes at both ends, and combined for oral inhalation, the larger of the above-mentioned tubes One end is connected to the smoke outlet of the smoking set, and the smaller end is used for oral inhalation, and the outer diameter of the smaller end is 3mm-4mm.
  • the electronic smoking set is the smoking set disclosed in the utility model patent CN201390000190.6 or a commercially available electronic smoking set.
  • Nicotine salt solution acrylic acid nicotine salt, concentration: 1.5%, solvent: water and propylene carbonate (volume ratio 1.5:8.5), pH value: 6.5, (add to) total amount: 100ml;
  • Alkaline solution potassium cysteic acid, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (add to) total amount: 100ml.
  • Atomization device Two identical independent e-cigarettes are connected by two independent and incommunicable tubes (such as rubber tubes, silicone tubes) of different sizes at both ends, and combined for oral inhalation, the larger of the above-mentioned tubes One end is connected to the smoke outlet of the smoking set, and the smaller end is used for oral inhalation, and the outer diameter of the smaller end is 3mm-4mm.
  • the electronic smoking set is the smoking set disclosed in the utility model patent CN201390000289.6 or a commercially available electronic smoking set.
  • Nicotine salt solution nicotine gluconate salt, concentration: 1.5%, solvent: water, propylene glycol, polyethylene glycol 200 (volume ratio 1:8:1), pH value: 5.3, (add to) total: 10ml ;
  • Alkaline solution ammonium valine, concentration: 3.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (add to) total amount: 100ml.
  • Atomization device Two identical independent e-cigarettes are connected by two independent and incommunicable tubes (such as rubber tubes, silicone tubes) of different sizes at both ends, and combined for oral inhalation, the larger of the above-mentioned tubes One end is connected to the smoke outlet of the smoking set, and the smaller end is used for oral inhalation, and the outer diameter of the smaller end is 3mm-4mm.
  • the electronic smoking set is the smoking set disclosed in the utility model patent CN201320734533.3 or a commercially available electronic smoking set.
  • Nicotine salt solution L-lactate nicotine salt, concentration: 0.5%, solvent: water and propylene carbonate (volume ratio 1.5:8.5), pH value: 4.2, (add to) total: 100ml;
  • Alkaline solution arginine, concentration: 4.5%, solvent: water and propylene glycol, glyceryl caprylate (volume ratio 1.5:6.5:2), (add to) total: 100ml.
  • Atomization device Two identical independent e-cigarettes are connected by two independent and incommunicable tubes (such as rubber tubes, silicone tubes) of different sizes at both ends, and combined for oral inhalation, the larger of the above-mentioned tubes One end is connected to the smoke outlet of the smoking set, and the smaller end is used for oral inhalation, and the outer diameter of the smaller end is 3mm-4mm.
  • the electronic smoking set is the smoking set disclosed in the utility model patent CN201320734377.0 or a commercially available electronic smoking set.
  • Nicotine salt solution nicotine salt of alpha-hydroxycaproic acid, concentration: 1.5%, solvent: water, propylene glycol, glycerin (volume ratio 1.5: 7.5: 1), pH value: 5.2, (add to) total: 100 ml;
  • Alkaline solution triethanolamine, concentration: 1.5%, solvent: propylene glycol, (add to) total amount: 100ml.
  • Atomization device Two identical independent e-cigarettes are connected by two independent and incommunicable tubes (such as rubber tubes, silicone tubes) of different sizes at both ends, and combined for oral inhalation, the larger of the above-mentioned tubes One end is connected to the smoke outlet of the smoking set, and the smaller end is used for oral inhalation, and the outer diameter of the smaller end is 3mm-4mm.
  • the electronic smoking set is the smoking set disclosed in the utility model patent CN201390000294.7 or a commercially available electronic smoking set.
  • Nicotine salt solution nicotine caprylate salt, concentration: 4.5%, solvent: water, propylene glycol, polyhexaglycerol (volume ratio 1.5:7.5:1), pH value: 5.6, (add to) total: 100ml;
  • Alkaline solution sodium glycinate, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (add to) total amount: 100ml.
  • Atomization device Two identical independent e-cigarettes are connected by two independent and incommunicable tubes (such as rubber tubes, silicone tubes) of different sizes at both ends, and combined for oral inhalation, the larger of the above-mentioned tubes One end is connected to the smoke outlet of the smoking set, and the smaller end is used for oral inhalation, and the outer diameter of the smaller end is 3mm-4mm.
  • the electronic smoking set is the smoking set disclosed in the utility model patent CN201390000291.3 or a commercially available electronic smoking set.
  • Nicotine salt solution nicotine benzoate, concentration: 2.5%, solvent: water, propylene glycol, polydipropylene glycol (volume ratio 1.5: 7.5: 1), pH value: 5.0, (add to) total: 200ml;
  • Alkaline solution lysine, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5: 8.5), (add to) total amount: 100 ml.
  • Atomization device Two identical independent e-cigarettes are connected by two independent and incommunicable tubes (such as rubber tubes, silicone tubes) of different sizes at both ends, and combined for oral inhalation, the larger of the above-mentioned tubes One end is connected to the smoke outlet of the smoking set, and the smaller end is used for oral inhalation, and the outer diameter of the smaller end is 3mm-4mm.
  • the electronic smoking set is the smoking set disclosed in the invention patent CN201410371441.2 or a commercially available electronic smoking set.
  • Nicotine salt solution nicotine salicylate, concentration: 0.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), pH value: 6.4, (add to) total: 100ml;
  • Alkaline solution thiamine, concentration: 0.5%, solvent: water and propylene glycol, glycerol acetate (volume ratio 1.5:6.5:2), (add to) total: 100ml.
  • Atomization device Two identical independent e-cigarettes are connected by two independent and incommunicable tubes (such as rubber tubes, silicone tubes) of different sizes at both ends, and combined for oral inhalation, the larger of the above-mentioned tubes One end is connected to the smoke outlet of the smoking set, and the smaller end is used for oral inhalation, and the outer diameter of the smaller end is 3mm-4mm.
  • the electronic smoking set is the smoking set disclosed in the invention patent CN200710121524.6 or a commercially available electronic smoking set.
  • Nicotine salt solution mandelic acid (mandelic acid) nicotine salt, concentration: 3.5%, solvent: water, propylene glycol, polyethylene glycol 300 (volume ratio 1.5: 7.5: 1), pH value: 5.5, (add to ) Total amount: 100ml;
  • Alkaline solution sodium phenylalanine, concentration: 1.5%, solvent: water, propylene glycol, glycerin (volume ratio 1.5:6.5:2), (add to) total amount: 100ml.
  • Atomization device Two identical independent e-cigarettes are connected by two independent and incommunicable tubes (such as rubber tubes, silicone tubes) of different sizes at both ends, and combined for oral inhalation, the larger of the above-mentioned tubes One end is connected to the smoke outlet of the smoking set, and the smaller end is used for oral inhalation, and the outer diameter of the smaller end is 3mm-4mm.
  • the electronic smoking set is the smoking set disclosed in the utility model patent CN201621239037.0 or a commercially available electronic smoking set.
  • Nicotine salt solution Protocatechuic acid (3,4-dihydroxybenzoic acid) nicotine salt, concentration: 6.5%, solvent: water and propylene glycol, diethyl malate (volume ratio 1.5:8.0:0.5), pH Value: 5.2, (add to) total amount: 100ml;
  • Alkaline solution pyridoxamine, concentration: 2.5%, solvent: water and propylene glycol, glyceryl caproate (volume ratio 1.5:8.0:0.5), (add to) total: 100ml.
  • Atomization device Two identical independent e-cigarettes are connected by two independent and incommunicable tubes (such as rubber tubes, silicone tubes) of different sizes at both ends, and combined for oral inhalation, the larger of the above-mentioned tubes One end is connected to the smoke outlet of the smoking set, and the smaller end is used for oral inhalation, and the outer diameter of the smaller end is 3mm-4mm.
  • the electronic smoking set is the smoking set disclosed in the utility model patent CN201720429415.X or a commercially available electronic smoking set.
  • Nicotine salt solution nicotine glucuronic acid salt, concentration: 5.5%, solvent: water and propylene glycol, diethyl succinate (volume ratio 1.5:8.0:0.5), pH value: 4.5, (add to) total : 100ml;
  • Alkaline solution neomycamine, concentration: 2.5%, solvent: water, propylene glycol, glycerin (volume ratio 1.5:6.5:2), (add to) total amount: 100ml.
  • Atomization device Device example 4-1 in the specification (ie the device shown in Figures 1-1 to 6).
  • Nicotine salt solution nicotine ascorbate salt, concentration: 9.5%, solvent: water and propylene carbonate (volume ratio 1.5:8.5), pH value: 5.4, (add to) total: 100ml;
  • Alkaline solution pyridoxine, concentration: 2.5%, solvent: ethanol and propylene glycol (volume ratio 1:9), (add to) total amount: 100ml.
  • Atomization device Device example 4-1 in the specification (ie the device shown in Figures 1-1 to 6).
  • Nicotine salt solution Angelica acid ((Z)-2-methyl-2-butenoic acid) nicotine salt, concentration: 3.5%, solvent: water, propylene glycol, propylene carbonate (volume ratio 1.5:6.5:2) , PH value: 6.5, (add to) total amount: 100ml;
  • Alkaline solution meglumine, concentration: 1%, solvent: water and glycerol triacetate (volume ratio 1.5:8.5), (add to) total amount: 100ml.
  • Atomization device Device example 4-1 in the specification (ie the device shown in Figures 1-1 to 6).
  • Nicotine salt solution carboxyglutamate nicotine salt, concentration: 4.5%, solvent: water and propylene glycol (volume ratio 2:8), pH value: 6.2, (add to) total: 100ml;
  • Alkaline solution galactosamine, concentration: 2.5%, solvent: water, propylene glycol, glycerin (volume ratio 1.5: 7.5: 1), (add to) total amount: 100 ml.
  • Atomization device Device example 4-1 in the specification (ie the device shown in Figures 1-1 to 6).
  • Nicotine salt solution nicotine salt of glycyrrhizinate, concentration: 3.5%, solvent: water, propylene glycol, glyceryl caprylate (volume ratio 1.5:7.5:1), pH value: 6.1, (add to) total: 100ml;
  • Alkaline solution caffeine, concentration: 0.5%, solvent: ethanol and propylene glycol (volume ratio 0.5:9.5), (add to) total amount: 100ml.
  • Atomization device Device example 4-2 in the specification (ie the device shown in Figures 2-1 to 2).
  • Nicotine salt solution aspartic acid nicotine salt, concentration: 3.5%, solvent: water and propylene glycol, triacetin (volume ratio 1.5:6.5:2), pH value: 5.7, (add to) total : 100ml;
  • Alkaline solution 2-deoxyglycosamine, concentration: 4.5%, solvent: water, propylene glycol, glycerin (volume ratio 1.5:7.0:1.5), (add to) total amount: 100ml.
  • Atomization device Device example 4-3 in the specification (ie the device shown in Figure 3-1).
  • Nicotine salt solution inosinic acid nicotine salt, concentration: 2.5%, solvent: water, propylene glycol, glyceryl caprylate (volume ratio 1.5: 7.5: 1), pH value: 6.2, (add to) total: 100ml ;
  • Alkaline solution tributanolamine, concentration: 0.8%, solvent: propylene glycol, total amount (to be added): 100ml.
  • Atomization device Device example 4-3 in the specification (ie the device shown in Figure 3-1).
  • Nicotine salt solution nicotine cinnamic acid salt, concentration: 2.5%, solvent: water, propylene glycol, propylene carbonate (volume ratio 1.5:6.5:2), pH value: 5.2, (add to) total: 100ml;
  • Alkaline solution Glucosamine, concentration: 0.5%, solvent: water and poloxamer 124, (add to) total amount: 100ml.
  • Atomization device Device example 4-3 in the specification (ie the device shown in Figure 3-1).
  • Nicotine salt solution nicotine hydrochloride salt, concentration: 2.5%, solvent: water and propylene glycol, glycerol tripropionate (volume ratio 1.5:7.5:1), pH value: 4.8, (add to) total: 100ml;
  • Alkaline solution N-acetyl-D-glucosamine, concentration: 1.0%, solvent: benzyl benzoate and ethanol (volume ratio 8.5: 1.5), (add to) total amount: 100 ml.
  • Atomization device Device example 4-3 in the specification (ie the device shown in Figure 3-1).
  • Nicotine salt solution nicotine sulfate salt, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5: 8.5), pH value: 4.2, total (add to): 100ml; propylene glycol
  • Alkaline solution dipropanolamine, concentration: 0.5%, solvent: dodecenyl acetate and ethanol (volume ratio 8.5: 1.5), (add to) total amount: 100 ml.
  • Atomization device device example 4-4 in the specification, the lower and upper shells are set according to device example 4-4 in the specification, according to the utility model patent CN206079032U or CN201420045870.6 disclosed power supply components, atomization subsystem, accessories, etc. , There are two sets of the same but independent and unconnected devices containing the power components, atomization subsystems, accessories and other components disclosed in the above patent (all the same as the patent); or device example 4-1 in the specification (That is, the device shown in Figures 1-1 to 6).
  • Nicotine salt mixture nicotine phosphate, content: 1.5%, diluent or aerosol generator: camphor, (add to) total: 100g;
  • Alkaline solution ethanolamine, concentration: 0.5%, solvent: ethyl vanillate and ethanol (volume ratio 8.5: 1.5), (add to) total amount: 100 ml.
  • Atomization device Device example 4-2 in the specification (ie the device shown in Figures 2-1 to 2).
  • Nicotine salt solution nicotine besylate, concentration: 4.5%, solvent: water, propylene glycol, propylene carbonate (volume ratio 1.5:6.5:2), pH value: 5.6, (add to) total: 100ml;
  • Alkaline solution tromethamine, concentration: 2.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (add to) total amount: 100ml.
  • Atomization device device example 4-4 in the specification, the lower and upper shells are set according to device example 4-4 in the specification, according to the utility model patent CN206079032U or CN201420045870.6 disclosed power supply components, atomization subsystem, accessories, etc. , There are two sets of the same but independent and unconnected devices containing the power components, atomization subsystems, accessories and other components disclosed in the above patent (all the same as the patent); or device example 4-1 in the specification (That is, the device shown in Figures 1-1 to 6).
  • Nicotine salt mixture nicotine metasulfite, content: 2.5%, diluent or aerosol generator: vanillic acid, (add to) total: 100g;
  • Alkaline solution diethanolamine, concentration: 0.8%, solvent: triethyl citrate, (add to) total amount: 100ml.
  • Atomization device device example 4-4 in the specification, the lower and upper shells are set according to device example 4-4 in the specification, according to the power components, atomization subsystems, accessories, etc. disclosed in the invention patent CN206079032U or CN200910080147.5, There are two sets of identical but independent devices containing the power supply components, atomization subsystems, and accessories disclosed in the above-mentioned patent (all the same as those in the patent); or the device example 4-1 in the specification (That is, the device shown in Figures 1-1 to 6).
  • Nicotine salt solution nicotine malate, concentration: 2.5%, solvent: water and propylene glycol, polydipropylene glycol (volume ratio 1.5: 7.5: 1), pH value: 5.0, (add to) total: 100ml;
  • Alkaline solution sodium glutamate, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (add to) total amount: 100ml.
  • Atomization device Two identical independent e-cigarettes are connected by two independent and incommunicable tubes (such as rubber tubes, silicone tubes) of different sizes at both ends, and combined for oral inhalation, the larger of the above-mentioned tubes One end is connected to the smoke outlet of the smoking set, and the smaller end is used for oral inhalation, and the outer diameter of the smaller end is 3mm-4mm.
  • the electronic smoking set is the smoking set disclosed in the invention patent CN201410371441.2 or a commercially available electronic smoking set.
  • Nicotine salt solution nicotine salt of licorice diacid, concentration: 2.5%, solvent: water, propylene glycol, polydipropylene glycol (volume ratio 1.5: 7.5: 1), pH value: 5.0, (add to) total: 100ml;
  • Alkaline solution meglumine, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (add to) total amount: 100ml.
  • Atomization device the same as in Example 34.
  • Nicotine salt solution nicotine tartrate, concentration: 2.5%, solvent: water and propylene glycol, polydipropylene glycol (volume ratio 1.5: 7.5: 1), pH value: 5.0, (add to) total: 100ml;
  • Alkaline solution sodium dihydrochalcone, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (add to) total amount: 100ml.
  • Nicotine salt solution nicotine gluconate salt, concentration: 2.5%, solvent: water and propylene glycol, polydipropylene glycol (volume ratio 1.5: 7.5: 1), pH value: 5.0, (add to) total: 100ml;
  • Alkaline solution trisodium glycyrrhizinate, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (add to) total amount: 100ml.
  • Nicotine salt solution nicotine oxalate, concentration: 2.5%, solvent: water and propylene glycol, polydipropylene glycol (volume ratio 1.5: 7.5: 1), pH value: 5.0, (add to) total: 100ml;
  • Alkaline solution meglumine, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5: 8.5), (add to) total amount: 100 ml.
  • Nicotine salt solution galactose diacid nicotine salt, concentration: 2.5%, solvent: water and propylene glycol, polydipropylene glycol (volume ratio 1.5: 7.5: 1), pH value: 5.0, (add to) total: 100ml ;
  • Alkaline solution sodium saccharin, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (add to) total amount: 100ml.
  • Nicotine salt solution nicotine glucarate, concentration: 2.5%, solvent: water, propylene glycol, polydipropylene glycol (volume ratio 1.5: 7.5: 1), pH value: 5.0, (add to) total: 100ml ;
  • Alkaline solution pyridoxine, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (add to) total amount: 100ml.
  • Nicotine salt solution nicotine glutamate, concentration: 2.5%, solvent: water, propylene glycol, polydipropylene glycol (volume ratio 1.5: 7.5: 1), pH value: 5.0, (add to) total: 100ml;
  • Alkaline solution thiamine, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5: 8.5), (add to) total amount: 100 ml.
  • Nicotine salt solution aspartic acid nicotine salt, concentration: 2.5%, solvent: water, propylene glycol, polydipropylene glycol (volume ratio 1.5: 7.5: 1), pH value: 5.0, (add to) total: 100ml ;
  • Alkaline solution pyridoxamine, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (add to) total amount: 100ml.
  • Atomization device the same as in Example 34.
  • Nicotine salt solution nicotine benzoate, concentration: 2.5%, solvent: water and propylene glycol, polydipropylene glycol (volume ratio 1.5: 7.5: 1), pH value: 5.0, (add to) total: 100ml;
  • Alkaline solution arginine, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (add to) total: 100ml.
  • Atomization device the same as in Example 34.
  • Nicotine salt solution nicotine salt of ascorbate, concentration: 2.5%, solvent: water, propylene glycol, polydipropylene glycol (volume ratio 1.5: 7.5: 1), pH value: 5.0, (add to) total: 100ml;
  • Alkaline solution lysine, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5: 8.5), (add to) total amount: 100 ml.
  • Atomization device the same as in Example 34.
  • Nicotine salt solution nicotine salt of dehydroascorbate, concentration: 2.5%, solvent: water and propylene glycol, polydipropylene glycol (volume ratio 1.5: 7.5:1), pH value: 5.0, (add to) total: 100ml;
  • Alkaline solution sodium methionine, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (add to) total amount: 100ml.
  • Nicotine salt solution nicotine erythorbate, concentration: 2.5%, solvent: water, propylene glycol, polydipropylene glycol (volume ratio 1.5:7.5:1), pH value: 5.0, (add to) total: 100ml;
  • Alkaline solution sodium glycinate, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (add to) total amount: 100ml.
  • Atomization device the same as in Example 34.
  • Nicotine salt solution nicotine hydrochloride salt, concentration: 2.5%, solvent: water, propylene glycol, polydipropylene glycol (volume ratio 1.5:7.5:1), pH value: 5.0, (add to) total: 100ml;
  • Alkaline solution ethanolamine, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (add to) total amount: 100ml.
  • Atomization device the same as in Example 34.
  • Nicotine salt solution nicotine citrate salt, concentration: 2.5%, solvent: water and propylene glycol, polydipropylene glycol (volume ratio 1.5: 7.5: 1), pH value: 5.0, (add to) total: 100ml;
  • Alkaline solution sodium hydrogen phosphate, concentration: 1.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), (add to) total amount: 100ml.
  • Nicotine salt mixture nicotine isovalerate, content: 1.5%, diluent or aerosol generator: sorbitol, (add to) total: 100g;
  • Alkaline solution triethanolamine, concentration: 1.5%, solvent: propylene glycol, (add to) total amount: 100ml.
  • Atomization device Two identical independent e-cigarettes are connected by two independent and incommunicable tubes (such as rubber tubes, silicone tubes) of different sizes at both ends, and combined for oral inhalation, the larger of the above-mentioned tubes One end is connected to the smoke outlet of the smoking set, and the smaller end is used for oral inhalation, and the outer diameter of the smaller end is 3mm-4mm.
  • the electronic smoking set is the smoking set disclosed in the utility model patent CN201390000294.7 or a commercially available electronic smoking set.
  • Nicotine salt mixture 2-methylbutyrate nicotine salt, content: 3.5%, diluent or aerosol generator: 1,3-dihydroxyacetone, (add to) total amount: 100g;
  • Alkali mixture urea, content: 1.5%, diluent or aerosol generating agent: sorbitol, (add to) total amount: 100g.
  • Atomization device Two identical independent e-cigarettes are connected by two independent and incommunicable tubes (such as rubber tubes, silicone tubes) of different sizes at both ends, and combined for oral inhalation, the larger of the above-mentioned tubes One end is connected to the smoke outlet of the smoking set, and the smaller end is used for oral inhalation, and the outer diameter of the smaller end is 3mm-4mm.
  • the electronic smoking set is the smoking set disclosed in the utility model patent CN201390000291.3 or a commercially available electronic smoking set.
  • Nicotine salt mixture nicotine benzoate, content: 2.5%, diluent or aerosol generator: erythrose, (add to) total: 100g;
  • Alkali mixture meglumine, content: 1.0%, diluent or aerosol generator: xylitol, (add to) total amount: 100g.
  • Atomization device Two identical independent e-cigarettes are connected by two independent and incommunicable tubes (such as rubber tubes, silicone tubes) of different sizes at both ends, and combined for oral inhalation, the larger of the above-mentioned tubes One end is connected to the smoke outlet of the smoking set, and the smaller end is used for oral inhalation, and the outer diameter of the smaller end is 3mm-4mm.
  • the electronic smoking set is the smoking set disclosed in the invention patent CN201410371441.2 or a commercially available electronic smoking set.
  • Nicotine salt solution phenylacetic acid nicotine salt, concentration: 0.5%, solvent: water and propylene glycol (volume ratio 1.5:8.5), pH value: 6.4, (add to) total: 100ml;
  • Alkali mixture thiamine, content: 2.0%, diluent or aerosol generator: erythritol, (add to) total: 100g.
  • Atomization device Two identical independent e-cigarettes are connected by two independent and incommunicable tubes (such as rubber tubes, silicone tubes) of different sizes at both ends, and combined for oral inhalation, the larger of the above-mentioned tubes One end is connected to the smoke outlet of the smoking set, and the smaller end is used for oral inhalation, and the outer diameter of the smaller end is 3mm-4mm.
  • the electronic smoking set is the smoking set disclosed in the invention patent CN200710121524.6 or a commercially available electronic smoking set.
  • Nicotine salt mixture Nicotine isocaproate salt, content: 2.0%, diluent or aerosol generator: fructose, (add to) total: 100g;
  • Alkali mixture Diarno, content: 1.0%, diluent or aerosol generator: menthol, (add to) total amount: 100g.
  • Atomization device Two identical independent e-cigarettes are connected by two independent and incommunicable tubes (such as rubber tubes, silicone tubes) of different sizes at both ends, and combined for oral inhalation, the larger of the above-mentioned tubes One end is connected to the smoke outlet of the smoking set, and the smaller end is used for oral inhalation, and the outer diameter of the smaller end is 3mm-4mm.
  • the electronic smoking set is the smoking set disclosed in the utility model patent CN201621239037.0 or a commercially available electronic smoking set.
  • Nicotine salt mixture nicotine butyrate salt, content: 4.5%, diluent or aerosol generator: lactic acid, (add to) total amount: 100g;
  • Alkali mixture arginine, content: 85%, diluent or aerosol generating agent: menthol, (add to) total: 100g.
  • Atomization device Two identical independent e-cigarettes are connected by two independent and incommunicable tubes (such as rubber tubes, silicone tubes) of different sizes at both ends, and combined for oral inhalation, the larger of the above-mentioned tubes One end is connected to the smoke outlet of the smoking set, and the smaller end is used for oral inhalation, and the outer diameter of the smaller end is 3mm-4mm.
  • the electronic smoking set is the smoking set disclosed in the utility model patent CN201720429415.X or a commercially available electronic smoking set.
  • Nicotine salt mixture nicotine propionate, content: 2.0%, diluent or aerosol generator: lauric acid, (add to) total: 100g;
  • Alkaline solution Tripentanolamine, concentration: 2.5%, solvent: water, propylene glycol, glycerin (volume ratio 1.5:6.5:2), (add to) total amount: 100ml.
  • Atomization device Device example 4-1 in the specification (ie the device shown in Figures 1-1 to 6).
  • Nicotine salt mixture nicotine acetate, content: 2.5%, diluent or aerosol generator: xylose, (add to) total: 100g;
  • Alkali mixture ammonium glycinate, content: 75%, diluent or aerosol generator: myristyl alcohol, (add to) total amount: 100g.
  • Atomization device Two identical independent e-cigarettes are connected by two independent and incommunicable tubes (such as rubber tubes, silicone tubes) of different sizes at both ends, and combined for oral inhalation, the larger of the above-mentioned tubes One end is connected to the smoke outlet of the smoking set, and the smaller end is used for oral inhalation, and the outer diameter of the smaller end is 3mm-4mm.
  • the electronic smoking set is the smoking set disclosed in the utility model patent CN201720429415.X or a commercially available electronic smoking set.
  • Nicotine salt solution nicotine benzoate, concentration: 3.5%, solvent: water, triethylene glycol, propylene carbonate (volume ratio 1.5:6.5:2), pH value: 6.5, (add to) total: 100ml ;
  • Alkaline solution meglumine, concentration: 1%, solvent: water and tetraethylene glycol (volume ratio 3:7), (add to) total amount: 100ml.
  • Atomization device Two identical independent e-cigarettes are connected by two independent and incommunicable tubes (such as rubber tubes, silicone tubes) of different sizes at both ends, and combined for oral inhalation, the larger of the above-mentioned tubes One end is connected to the smoke outlet of the smoking set, and the smaller end is used for oral inhalation, and the outer diameter of the smaller end is 3mm-4mm.
  • the electronic smoking set is the smoking set disclosed in the utility model patent CN201621239037.0 or a commercially available electronic smoking set.
  • Nicotine salt solution carboxyglutamate nicotine salt, concentration: 1.5%, solvent: water and ethyl lactate (volume ratio 2:8), pH value: 6.2, (add to) total: 100ml;
  • Alkaline solution lysine, concentration: 2.5%, solvent: water, propylene glycol, glycerin (volume ratio 1.5:7.5:1), (add to) total amount: 100ml.
  • Atomizing device Device example 4-2 in the specification (ie the device shown in Figures 21-2).
  • Nicotine salt solution nicotine salt of glycyrrhizinate, concentration: 0.5%, solvent: water and propylene glycol, triacetin (volume ratio 1.5:6.5:2), pH value: 6.1, (add to) total: 100ml ;
  • Alkaline solution tromethamine, concentration: 0.5%, solvent: ethanol and ethyl myristate (volume ratio 0.5:9.5), (add to) total amount: 100ml.
  • Atomization device Two identical independent e-cigarettes are connected by two independent and unconnected tubes (such as rubber tubes, silicone tubes) of different sizes at both ends, and used for oral inhalation after being combined.
  • the larger of the above-mentioned tubes One end is connected to the smoke outlet of the smoking set, and the smaller end is used for oral inhalation, and the outer diameter of the smaller end is 3mm-4mm.
  • the electronic smoking set is the smoking set disclosed in the invention patent CN200710121524.6 or a commercially available electronic smoking set.
  • Nicotine salt mixture nicotine salt of glycyrrhizinate, content: 1.0%, diluent or aerosol generator: ethyl vanillin, (add to) total: 100g;
  • Alkaline solution diethanolamine, concentration: 0.5%, solvent: ethanol and dimethyl dodecanedioate (volume ratio 0.5:9.5), (add to) total: 100ml.
  • Atomization device Two identical independent e-cigarettes are connected by two independent and unconnected tubes (such as rubber tubes, silicone tubes) of different sizes at both ends, and used for oral inhalation after being combined.
  • the larger of the above-mentioned tubes One end is connected to the smoke outlet of the smoking set, and the smaller end is used for oral inhalation, and the outer diameter of the smaller end is 3mm-4mm.
  • the electronic smoking set is the smoking set disclosed in the utility model patent CN201621239037.0 or a commercially available electronic smoking set.
  • Nicotine salt mixture 2-methylbutyrate nicotine salt, content: 75%, diluent or aerosol generator: phenylacetic acid, (add to) total: 100g;
  • Alkali mixture urea, content: 1.0%, diluent or aerosol generator: arabinose, (add to) total: 100g.
  • Atomization device Two identical independent e-cigarettes are connected by two independent and unconnected tubes (such as rubber tubes, silicone tubes) of different sizes at both ends, and used for oral inhalation after being combined.
  • the larger of the above-mentioned tubes One end is connected to the smoke outlet of the smoking set, and the smaller end is used for oral inhalation, and the outer diameter of the smaller end is 3mm-4mm.
  • the electronic smoking set is the smoking set disclosed in the utility model patent CN201390000291.3 or a commercially available electronic smoking set.
  • Nicotine salt solution nicotine isopropionate, concentration: 1.5%, solvent: 2,2-dimethyl-1,3-dioxolane-4-methanol, (add to) total amount: 100ml;
  • Alkaline solution triethanolamine, concentration: 1.5%, solvent: 1,3-propanediol monolactate, (add to) total amount: 100ml.
  • Embodiment 62-1 Device example 4-1 in the specification (ie, the device shown in Figures 1-1 to 6).
  • Embodiment 62-2 Others are the same, only the two “mist or smoke passages or guides 1” in the atomization device in the embodiment are changed to “the other end communicates with a suction (mouth) hole” It is “the other end is connected with one suction (nozzle) hole”, that is, two suction (nozzle) holes become one suction (nozzle) hole.
  • Nicotine salt solution L-gulonic acid nicotine salt, concentration: 1.5%, solvent: tetrahydrofuran polyethylene glycol ether, (add to) total amount: 100ml;
  • Alkaline solution chitobiose, concentration: 1.5%, solvent: water and 1,3-dioxolane-4-methanol (volume ratio 0.5:9.5), (add to) total amount: 100ml.
  • Embodiment 63-1 Device Example 4-2 in the specification (ie, the device shown in Figures 21-2).
  • Example 63-2 Other things are the same, only the two “mist or smoke passages or guides 1" in the atomization device in the example are changed to “the other end is communicated with a suction (mouth) hole” It is “the other end is connected with one suction (nozzle) hole", that is, two suction (nozzle) holes become one suction (nozzle) hole.
  • Nicotine salt solution D-lactate nicotine salt, concentration: 1.5%, solvent: 1,3-dioxan-5-ol, (add to) total amount: 100ml;
  • Alkaline solution triisopropanolamine, concentration: 1.5%, solvent: 1,3-propanediol monoethyl ester, (add to) total amount: 100 ml.
  • Embodiment 64-1 Device Example 4-3 in the specification (ie, the device shown in Figure 3-1).
  • Example 64-2 Others are the same, only the two “mist or smoke passages or guides 1" in the atomization device in the embodiment are changed to “the other end communicates with a suction (mouth) hole” It is “the other end is connected with one suction (nozzle) hole", that is, two suction (nozzle) holes become one suction (nozzle) hole.
  • Nicotine salt solution nicotine salt of glucoheptonate, concentration: 1.5%, solvent: water and 1,3-dioxan-5-ol (volume ratio 1:9), pH value: 5.2, (add to) Total amount: 100ml;
  • Alkaline solution Dipentanolamine, concentration: 1.5%, solvent: 1,3-propanediol monopropyl ester, (add to) total amount: 100ml.
  • Example 65-1 Device example 4-4 in the specification, the lower and upper shells are set according to device example 4-4 in the specification, according to the power supply assembly, atomization subsystem, and accessories disclosed in the invention patent CN206079032U or CN200910080147.5 Etc., there are two sets of the same but independent and unconnected devices containing the power components, atomization subsystems, accessories and other components disclosed in the above patent (all the same as the patent); or the device example in the specification 4- 1 (ie the device shown in Figures 1-1 to 6).
  • Example 65-2 Other things are the same, only the two “mist or smoke passages or guides 1" in the atomization device in the embodiment are changed to “the other end communicates with a suction (mouth) hole” It is “the other end is connected with one suction (nozzle) hole", that is, two suction (nozzle) holes become one suction (nozzle) hole.
  • the preparation method of nicotine salt in the above-mentioned embodiment adopts methods known in the art or directly adopts nicotine salt therein, such as CN1607950A, CN101222915A, CN201480025499.X, CN201580038462.5, CN201180028544.3, CN201680079884.1, CN201180022735.9 , CN03812809.8, etc.;
  • the preparation method of the above nicotine salt can also adopt the following simple methods:
  • the pH regulators of the above embodiments are each (0.1 mol/l) acid or hydrochloric acid or sodium hydroxide solution that forms a salt with nicotine;
  • the above nicotine salt solution/mixture and alkali solution/mixture are respectively placed in the two isolated and unconnected liquid storage chambers (parts)/or containing chambers (or containing chambers) in the above atomization device, or a combination of the above
  • the objects (I) and (II) are respectively pre-placed in containers such as glass, ceramic, metal, etc., and then placed together with the above-mentioned container in the two isolated and incommunicable liquid storage chambers/or containing chambers (or chambers).
  • the reference substance is prepared according to the following method:
  • nicotine salt solution or nicotine salt mixture such as 10ml or 10g
  • its alkali solution or alkali mixture such as 10ml or 10g
  • 10ml of nicotine salt solution (or 10g of nicotine salt mixture) and 10ml of alkali solution (or 10g of alkali mixture) in each corresponding embodiment are uniformly mixed to obtain the reference substance of each corresponding control example
  • use this The mixed reference substance replaces the nicotine salt solution and alkali solution/or alkali mixture in the corresponding embodiment.
  • Atomization device the same as its corresponding embodiment.
  • Nicotine salt solution or nicotine salt mixture it corresponds to the nicotine salt solution or nicotine salt mixture in the embodiment, that is, the same as the corresponding embodiment, unchanged;
  • Neutralized alkali solution Take the same amount of the corresponding alkali in each corresponding embodiment, add about 85% of the total amount of the corresponding solvent, mix well, and adjust with (0.1mol/l) hydrochloric acid or sodium hydroxide solution When the pH value reaches 6.9 ⁇ 7.1, add the remaining amount of the corresponding solvent to the full amount (ie 100ml); or
  • Neutralized alkali mixture Take the hydrochloride salt of the corresponding alkali in each corresponding embodiment (that is, it has been neutralized with hydrochloric acid), and add an appropriate amount of the corresponding diluent or aerosol generating agent in the corresponding embodiment , Make the equivalent content the same as the equivalent content of the alkali in the corresponding embodiment (calculated as the free alkali, the content is the same as the corresponding embodiment), and mix well.
  • the above-mentioned nicotine salt solution 1) and the neutralized alkali solution/or alkali mixture 2) are not mixed together, and the corresponding nicotine salt solution and alkali solution/or alkali mixture in the corresponding embodiments are replaced respectively.
  • Atomization device the same as its corresponding embodiment.
  • Alkaline nicotine salt solution the formula and preparation method are basically the same as the nicotine salt solution in the corresponding embodiment (the same as the corresponding embodiment, both have been 2 months from the production date), and the only difference is that it is formed Adjust the pH value of the original acid of the nicotine salt or the alkali in the alkali solution in the corresponding embodiment to 7.2 ⁇ 9.5 (wherein, comparative example 1 ⁇ 3: pH value to 7.2 ⁇ 7.5; comparative example 4 ⁇ 10: pH value To 7.6 ⁇ 8.0; comparative example 11 ⁇ 20: pH value to 8.1 ⁇ 8.5; comparative example 21 ⁇ 33: pH value to 8.6 ⁇ 8.9; comparative example 49 ⁇ 61: pH value to 9.0 ⁇ 9.5; if it is an alkali mixture, no Processing); and
  • Blank solvent without alkali or acid the alkali in the alkali solution in the corresponding embodiment is removed, and the others remain unchanged, that is, only the original corresponding blank solvent is used.
  • alkaline nicotine salt solution 1) and the blank solvent without alkali or acid 2) are not mixed together, and the corresponding nicotine salt solution and alkali solution/or alkali mixture in the corresponding embodiment are replaced respectively.
  • Atomization device the same as its corresponding embodiment.
  • Nicotine salt solution or nicotine salt mixture it corresponds to the nicotine salt solution or nicotine salt mixture in the embodiment, that is, the same as the corresponding embodiment, unchanged;
  • Blank solvent without alkali or acid the alkali in the alkali solution in the corresponding embodiment is removed, and the others remain unchanged, that is, only the original corresponding blank solvent is used.
  • the above-mentioned nicotine salt solution, or nicotine salt mixture 1) and the blank solvent without alkali or acid 2) are not mixed together, respectively, replace the corresponding nicotine salt solution and alkali solution/or alkali mixture in the corresponding embodiment .
  • Atomization device the same as its corresponding embodiment.
  • the two liquid storage chambers/accommodating chambers in the device corresponding to each embodiment are respectively injected with the nicotine salt solution (or nicotine salt mixture) and alkali solution (or alkali mixture) in this embodiment, and the nicotine salt solution ( (Or nicotine salt mixture) containing 2-20mg of nicotine (calculated as free nicotine) (that is, a single dose of nicotine is 2-20mg (calculated as free nicotine)), the alkali solution (or alkali mixture) and the nicotine The volume (or weight) of the salt solution (or nicotine salt mixture) is the same. Then the nicotine salt solution (or nicotine salt mixture) and alkali solution (or alkali mixture) are atomized. The user inhales the aerosol once every 6 seconds, and the two aerosols are inhaled deep into the lungs (meeting) and then exhaled Or spit it out until the above solution (or mixture) is atomized.
  • the two liquid storage chambers/liquid containing chambers in the device corresponding to each embodiment are respectively injected with the nicotine salt solution and the alkali solution in this embodiment, and the volume numbers of the nicotine salt solution and the nicotine salt solution are both 0.50 ml. Then the nicotine salt solution and alkali solution are atomized, and the user inhales the aerosol from the mouth (or/and nasal cavity) every 6 seconds, swallows through the throat to the lungs, and inhales the two aerosols deep into the lungs ( After meeting), exhale from the nasal cavity until the above solution is atomized.
  • the two liquid storage chambers/accommodating chambers in each comparative example corresponding to the device in its embodiment are injected with the reference substance in the comparative example, and the two liquid storage chambers/accommodating chambers are filled with the reference substance
  • the volume number (or weight) of is the same and is the same as the volume number (or weight of the mixture) injected into the embodiment.
  • the solution (or mixture) is atomized, and the user inhales the aerosol from the oral cavity (or/and nasal cavity) every 6 seconds, and swallows it through the throat to the lungs.
  • the two aerosols are inhaled deep into the lungs (meeting) Then exhale from the nasal cavity until the above solution (or mixture) is atomized.
  • the atomization speed is the same as the corresponding embodiment.
  • the two liquid storage chambers/accommodating chambers in the device in each comparative example corresponding to the device in the embodiment are respectively injected with the reference 1) in the comparative example, that is, the nicotine salt in the corresponding embodiment Solution (or nicotine salt mixture), and reference 2), that is, the neutralized alkali solution (or neutralized alkali mixture) of the control example, the nicotine salt solution (or nicotine salt mixture) and the neutralized
  • the volume of the neutralized alkali solution (or the weight of the neutralized alkali mixture) is the same and is the same as the volume of the solution (or the weight of the mixture) injected according to the embodiment.
  • the nicotine salt solution (or nicotine salt mixture) and the neutralized alkali solution (or neutralized alkali mixture) are atomized, and the user inhales air from the mouth (or/and nasal cavity) every 6 seconds
  • the two aerosols are inhaled deep into the lungs (when they meet) and then exhaled from the nasal cavity until the above-mentioned solution (or mixture) is atomized.
  • the atomization speed is the same as the corresponding embodiment.
  • the two liquid storage chambers/accommodating chambers in each comparative example corresponding to the device in its embodiment are respectively injected with the reference substance 1): alkaline nicotine salt solution and reference substance 2): Blank solvent without alkali or acid.
  • the volume of the reference substance 1) and reference substance 2) are the same and the same as the volume of the solution injected into the embodiment. Then the reference substance 1) and reference substance 2) are atomized.
  • the user inhales the aerosol from the oral cavity (or/and nasal cavity) every 6 seconds, and then swallows it through the throat to the lungs.
  • the two aerosols are inhaled deep into the lungs. Exhale from the nasal cavity after meeting (meeting) until the above-mentioned solution (or mixture) is atomized.
  • the atomization speed is the same as the corresponding embodiment.
  • the two liquid storage chambers/accommodating chambers in the device in each comparative example corresponding to its embodiment are respectively injected into the reference 1): nicotine salt solution or nicotine salt Mixture and reference substance 2): a blank solvent that does not contain alkali or acid.
  • the volume of the reference substance 1) and reference substance 2) solutions are the same and the same as the volume of the solution injected into the embodiment.
  • the reference substance 1) and reference substance 2) are atomized.
  • the user inhales the aerosol from the oral cavity (or/and nasal cavity) every 6 seconds, and swallows it through the throat to the lungs.
  • the two aerosols are inhaled deep into the lungs. Exhale from the nasal cavity after meeting (meeting) until the above-mentioned solution (or mixture) is atomized.
  • the atomization speed is the same as the corresponding embodiment.
  • the analysis of the effect of nicotine can be done according to standard methods known in the art, such as using biological analysis for the determination of nicotine in the recipient’s plasma: the user inhales the aerosol, and after the completion of the atomization process, at 10min, 20min, 30min , 1hr, 1.5hr, 2hr, 3hr, 4hr, 6hr, 8hr, 12hr to measure the user's nicotine (as free nicotine) plasma concentration, and calculate AUC 0 ⁇ (the area enclosed by the plasma concentration curve versus time , Reflecting the bioavailability/degree of nicotine).
  • the selected 4 sensory quality testing indicators are: throat (or choking) sensation, irritation, satisfaction, comfort, the throat sensation (or choking) refers to: The free nicotine in the smoke generated by inhaling the e-cigarette liquid through atomization chokes the throat to cause coughing, and makes the throat feel oppressive, such as "choking the smoke” uncomfortable feeling; the irritation refers to: inhalation
  • the smoke produced by the atomization of e-cigarette liquid has various uncomfortable feelings on sensory organs including the mouth, throat, and nasal cavity, such as cold, heat, pain, itching, sour, pungent, spicy, bitter, salty, numb, astringent, etc.
  • the satisfaction refers to the comprehensive feeling of the intensity and concentration of the smoke produced by the atomization of the e-cigarette liquid on the sensory organs;
  • the comfort refers to the smoke produced by the atomization of the e-cigarette liquid The effect on oral comfort after inhalation and exhalation;
  • the overall circulation evaluation method refers to: evaluation The smoke produced by the atomization of the e-cigarette liquid during smoking is inhaled through the mouth, swallowed from the throat to the lungs, exhaled from the nasal cavity, and the whole process of feeling and capturing the characteristics of the smoke.
  • the panelists are set to 51;
  • the judges use the scoring method to comprehensively score the sensory quality of the e-cigarette liquid, reflecting the degree of influence of various sensory quality test indicators on the quality of the e-cigarette.
  • the scoring method refers to: 4 sensory quality inspection indicators are scored on a scale of 0, 5, 10, 15, 20, and 25 (as shown in Table 3), and the 4 sensory quality inspection indicators can be evaluated individually , Can also be evaluated by the total score (up to 100 points). The higher the sensory quality score, the better the quality of the e-cigarette liquid.
  • the minimum scoring unit of the scoring value is 0.5.
  • the method for statistically calculating the sensory quality test results of the reviewers includes the following steps: scoring all sensory quality test indicators of all reviewers, Remove a minimum score and a high score respectively, and calculate the average value of the effective score for each sensory quality test index.
  • the nicotine salt solution samples in the example and the control example were encapsulated in a colorless and transparent 5ml ampoule (sealed), and placed at a temperature of 35 ⁇ 40°C, a relative humidity of 60 ⁇ 75% and a medium light intensity ( In the same environment of about 50 ⁇ 150LUX), take it out at the same time after 1 ⁇ 2 months, and measure the total nicotine content (bound and free state) and related substances (oxidative degradation products of nicotine) in the nicotine salt solution sample (The result is expressed by the relative label amount), calculate the relative 0 month (that is, before putting), the total nicotine amount decrease value A (%) and related substance increase value B (%).
  • Example (X) The performance of Example (X) is relatively smooth and supple when used, with better throat and/or oral sex, better satisfaction and comfort; while the corresponding control examples X-1 and X-3 perform more vigorously. Throat choking sensation is greater, or irritation is greater, throat and/or oral sex is poor, users (especially those who use tobacco products for the first time or infrequently) develop a certain degree of "resistance", involuntarily Refusal to inhale smoke into the lungs or mouth greatly affects satisfaction and comfort.
  • the device used in the embodiment has two suction (nozzle) holes or vent holes compared with one suction (nozzle) hole or vent hole test, which shows the following advantages:
  • the user can really experience two different flavors of smoke: Since the vents are straight through the mouth, the two vents can each output one flavor of smoke into the mouth, allowing users to experience two different flavors of smoke at the same time.
  • the two flavors of smoke are mixed in the smoking set in advance. In fact, only one flavor of smoke can be output in the mouth forever, and users can only experience one flavor of smoke.
  • Nicotine analysis 10min blood concentration C 10min (ng/ml) and AUC 0 ⁇ (ng ⁇ hr/ml) test results
  • Nicotine analysis 10min blood concentration C 10min (ng/ml) and AUC 0 ⁇ (ng ⁇ hr/ml) test results
  • Nicotine analysis 10min blood concentration C 10min (ng/ml) and AUC 0 ⁇ (ng ⁇ hr/ml) test results
  • Nicotine analysis 10min blood concentration C 10min (ng/ml) and AUC 0 ⁇ (ng ⁇ hr/ml) test results
  • Nicotine analysis 10min blood concentration C 10min (ng/ml) and AUC 0 ⁇ (ng ⁇ hr/ml) test results
  • Nicotine analysis 10min blood concentration C 10min (ng/ml) and AUC 0 ⁇ (ng ⁇ hr/ml) test results
  • the unit of C 10min in the above tables is ng/ml; the unit of AUC 0 ⁇ is ng ⁇ hr/ml.
  • Example 34 To Slap/choking Irritating Satisfaction Comfort Example 34 - 22.3 - 24.5 Example 35 - 23.3 - 23.5 Example 36 - 23.5 - 24.3 Example 37 - 23.3 - 24.5 Example 38 - 22.1 - 22.4 Example 39 - 22.8 - 22.2 Example 40 - 24.2 - 22.5 Example 41 - 23.5 - 22.3 Example 42 - 23.5 - 22.5 Example 43 - 22.0 - 22.0 Example 44 - 24.5 - 22.5 Example 45 - 23.0 - 22.0 Example 46 - 23.5 - 24.5 Example 47/Comparative Example 34 - 14.5 - 13.5 Example 48/Comparative Example 35 - 13.5 - 14.0
  • Example 11 1.03 1.31 Example 12 2.57 3.13 Comparative Example 11-1 10.4 11.3 Comparative Example 12-1 11.6 12.5 Comparative example 11-3 8.75 9.74 Comparative Example 12-3 9.36 10.2
  • Example 58 2.47 3.12
  • Example 59 2.76 3.42 Comparative Example 58-1 17.4 19.2 Comparative Example 59-1 15.4 16.8 Comparative Example 58-3 16.5 18.2 Comparative Example 59-3 16.2 18.1
  • A represents the decrease value of the total nicotine content relative to 0 month (%)
  • B represents the relative substance increase value (%) relative to 0 month.
  • Example 1 To A'(%) To A'(%) To A'(%) Example 1 0.62
  • Example 2 0.25
  • Example 3 0.73
  • Comparative Example 1-1 15.7 Comparative Example 2-1 13.9 Comparative Example 3-1 16.3 Comparative example 1-3 3.64 Comparative example 2-3 4.23 Comparative example 3-3 4.82
  • Example 32 0.56
  • Example 57 0.92 Example 58 0.89 Comparative Example 32-1 16.8 Comparative Example 57-1 17.2 Comparative Example 58-1 21.3 Comparative Example 32-3 24.8 Comparative Example 57-3 32.8 Comparative Example 58-3 35.3
  • A' represents the decrease value (%) of the total nicotine content relative to 0 months.

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Abstract

L'invention concerne un matériau de génération d'aérosol et un dispositif destiné à faire fumer le matériau de génération d'aérosol, ou à vaporiser, atomiser ou transformer en aérosol le matériau de génération d'aérosol. Le matériau de génération d'aérosol comprend la composition I, laquelle contient un sel de nicotine pharmaceutiquement acceptable et un agent de génération d'aérosol ou de fumée pharmaceutiquement acceptable, et la composition II, laquelle contient un alcali pharmaceutiquement acceptable, dont l'alcalinité est plus forte que celle de la nicotine (sa valeur de pKa étant supérieure à la valeur de pKa de la nicotine), et un agent de génération d'aérosol ou de fumée pharmaceutiquement acceptable, les compositions I et II mentionnées ci-dessus étant toutes deux inhalées par des utilisateurs/consommateurs dans un état fumé, vaporisé, atomisé ou aérosolisé. L'aérosol présente une concentration maximale, une bonne satisfaction physiologique, une sensation d'étouffement faible ou nulle, et une irritation faible ou nulle, passe bien à travers la gorge, et présente une biodisponibilité de nicotine élevée, et une bonne expérience consommateur.
PCT/CN2020/093337 2019-05-31 2020-05-29 Système de génération d'aérosol ou système à fumer, ou cigarette électronique et dispositif associé Ceased WO2020239083A1 (fr)

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US20230000136A1 (en) * 2019-12-02 2023-01-05 Jt International Sa E-liquid Composition Comprising 1,3-Propanediol Below 50% by Weight of the Composition
EP4094594A1 (fr) * 2021-05-25 2022-11-30 Consumer Brands International s.r.o. Remplissage d'une formulation de nicotine, en particulier un sachet de nicotine et son procédé de fabrication et mélange de sels de nicotine et son procédé de fabrication

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