[go: up one dir, main page]

WO2020111297A1 - Composition cosmétique comprenant comme principe actif un extrait composite à base de thym pour hydrater la peau - Google Patents

Composition cosmétique comprenant comme principe actif un extrait composite à base de thym pour hydrater la peau Download PDF

Info

Publication number
WO2020111297A1
WO2020111297A1 PCT/KR2018/014751 KR2018014751W WO2020111297A1 WO 2020111297 A1 WO2020111297 A1 WO 2020111297A1 KR 2018014751 W KR2018014751 W KR 2018014751W WO 2020111297 A1 WO2020111297 A1 WO 2020111297A1
Authority
WO
WIPO (PCT)
Prior art keywords
extract
skin
moisturizing
thyme
eoseongcho
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2018/014751
Other languages
English (en)
Korean (ko)
Inventor
박설웅
황은선
양정은
서슬아
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sd Biotechnologies Co Ltd
Original Assignee
Sd Biotechnologies Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sd Biotechnologies Co Ltd filed Critical Sd Biotechnologies Co Ltd
Priority to PCT/KR2018/014751 priority Critical patent/WO2020111297A1/fr
Priority to CN201880096652.6A priority patent/CN112584820A/zh
Publication of WO2020111297A1 publication Critical patent/WO2020111297A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present invention relates to a cosmetic composition for moisturizing the skin, and more particularly, to a cosmetic composition for moisturizing the skin, which contains thyme extract, machihyeon extract, coriander extract, and Eoseongcho extract as active ingredients.
  • the moisturizing cosmetic composition used for the skin maintains a certain amount of moisture on human hair or skin to make it soft and vibrant, and serves to prevent damage such as cracks and dryness. That is, the cosmetic composition for moisturizing the skin is used for the purpose of beautifying the skin or hair and keeping it healthy by supplying a certain amount of water to the skin or hair or by maintaining the water.
  • the skin is an organ that plays an essential role in maintaining moisture, and is known to be responsible for approximately 2/3 of the weight in controlling moisture. Therefore, in the field of cosmetics, functional studies related to supply and maintenance of moisture, that is, moisturizing, are actively being conducted. In addition, in recent years, the development of cosmetics that increase the moisturizing power of the skin by actively incorporating physiologically active substances obtained from natural substances or the like into cosmetics to further enhance the skin's own defense function has been actively progressed.
  • Patent Publication No. 10-2015-0045049 A cosmetic composition for moisturizing skin containing a plant extract and a method for manufacturing the same' is a cypress leaf liquid extract, pine needle liquid extract, pine needle leaf
  • the liquid extract, the green tea leaf liquid extract, and the fermented extract of the liquid extract of the medicinal herb have disclosed a skin moisturizing effect
  • Patent Publication No. 10-2017-0130865 'Anti-inflammatory or skin moisturizing composition comprising a plant extract,' is a fever. It has been disclosed that a combination of pew extract, honeyweed extract and cucumber extract is effective for anti-inflammatory or moisturizing the skin.
  • the present inventors conducted a study on the combination of natural substances with excellent skin moisturizing effect, and identified that the complex extract combining thyme extract, machihyeon extract, centella extract, and Eoseongcho extract exhibits excellent moisturizing effect, The present invention has been completed.
  • the main object of the present invention is to provide a cosmetic composition for moisturizing the skin, which includes thyme extract, machihyeon extract, centella extract, and Eoseongcho extract as active ingredients.
  • Another object of the present invention is to provide a food composition for moisturizing the skin, including thyme extract, machihyeon extract, centella extract, and Eoseongcho extract as active ingredients.
  • Another object of the present invention is to provide a quasi-drug composition for moisturizing the skin, which includes thyme extract, machihyeon extract, centella extract, and Eoseongcho extract as active ingredients.
  • the present invention provides a cosmetic composition for moisturizing the skin, which includes thyme extract, machihyeon extract, coriander extract, and Eoseongcho extract as active ingredients.
  • the present inventors conducted a study on a combination of substances having excellent skin moisturizing effect, and it was confirmed that each of the thyme extract, machi extract, coriander extract, and Eoseongcho extract among various plants has an effect on moisturizing the skin.
  • Machihyeon extract, jujube extract, and a combination extract of Eoseongcho extract significantly increases the production of hyaluronic acid in human keratinocytes, and significantly increases the expression of the moisturizing genes Filaggrin and Hyaluronan synthase-3, It proved to have excellent moisturizing effect.
  • the "time (Thymus vulgaris)" of the invention refers to a perennial plant of the dicotyledon plant currency neck Lamiaceae, and "Portulaca Oleracea (Portulaca oleracea L.)" means a purslane sentinel of the purslane, "Centella asiatica (Centella asiatica )” refers to the perennial plant of the apiaceae family of mountain birch, Ipanhwa-gun, a dicotyledonous plant, Houttuynia cordata Thunberg)” refers to the upper part of the flowering period of more than three hundred.
  • the above-mentioned thyme, marchi, coleoptera, and Eoseongcho of the present invention can be extracted from their natural, hybrid or varietal plants, and can also be extracted from plant tissue cultures.
  • skin moisturizing means to increase the feeling of moisture on the skin, and to maintain a moist state.
  • the time extract of the present invention, Machihyeon extract, Cypress extract, and Eoseongcho extract showed excellent water retention effect. From this, the composition comprising the Time extract, Machihyeon extract, Cypress extract, and Eoseongcho extract of the present invention is used for moisturizing the skin. It was confirmed that it can be used as.
  • extract is an extract obtained by extracting a plant, a dilution or concentrate of the extract, a dried product obtained by drying the extract, a crude or purified product of the extract, or a mixture thereof. It includes extracts of all formulations that can be formed using the extract itself and the extract.
  • the extract of the present invention may be preferably used in a dry powder form after extraction.
  • the method for extracting the extract is not particularly limited, and can be extracted according to a method commonly used in the art.
  • Non-limiting examples of the extraction method may include a hot water extraction method, an ultrasonic extraction method, a filtration method, and a reflux extraction method, and these may be performed alone or in combination of two or more extraction methods.
  • the type of the extraction solvent used for extracting the thyme, marchi, bottled grass, and Eoseongcho is not particularly limited, and any solvent known in the art may be used.
  • Non-limiting examples of the extraction solvent is water; C1 to C4 lower alcohols such as methanol, ethanol, propyl alcohol, and butyl alcohol; Polyhydric alcohols such as glycerin, butylene glycol, and propylene glycol; And hydrocarbon-based solvents such as methyl acetate, ethyl acetate, acetone, benzene, hexane, diethyl ether, and dichloromethane; Or a mixture of these may be used, preferably, water, lower alcohol, 1,3-butylene glycol, ethyl acetate may be used alone or in combination of two or more.
  • the extract extracted with hot water or cold immersion is filtered to remove floating solid particles, filtered using, for example, nylon, or filtered using a freeze filtration method, or used as it is or freeze-dried or hot-air dried, It can be used by drying using spray drying or the like.
  • the thyme extract is 0.01 to 10 parts by weight
  • the machihyeon extract is 0.01 to 2.5 parts by weight
  • the bottle extract is 0.01 to 7.5 parts by weight
  • the total composition is 100 parts by weight
  • Eoseongcho extract may be included in 0.01 to 2.5 parts by weight.
  • the thyme extract, machihyeon extract, centella extract, and Eoseongcho extract are mixed in a weight ratio of 4:1:2-4:1, and 4:1:3: Most preferably, it is mixed in a weight ratio of 1.
  • the composition for moisturizing the skin comprising the complex extract of thyme, machihyeon, coriander and Eoseongcho has no cytotoxicity, and increases the synthesis of hyaluronic acid, thereby improving skin moisturizing effect.
  • the thyme extract of the present invention Machihyeon extract, Cypress extract, and Eoseongcho extract have excellent skin moisturizing effect, and specifically, it is characterized by promoting the expression of Filaggrin and Hyaluronic acid genes.
  • the composition of the present invention has the effect of promoting Hyaluronan synthase-3 (HAS-3, skin moisturizing factor) gene expression.
  • the composition is a solution, external ointment, cream, foam, nutrient longevity, softening longevity, mask pack, softening water, emulsion, makeup base, essence, soap, liquid detergent, bathing agent, sunscreen Manufactured in a formulation selected from the group consisting of creams, sun oils, suspensions, emulsions, pastes, gels, lotions, powders, soaps, surfactant-containing cleansing, oils, powder foundations, emulsion foundations, wax foundations, patches and sprays It can, but is not limited to this.
  • the cosmetic composition of the present invention may further include one or more cosmetically acceptable carriers to be blended with general skin cosmetics, and for example, oil, water, surfactant, moisturizing agent, lower alcohol, Thickeners, chelating agents, pigments, preservatives, fragrances, etc. may be appropriately blended, but are not limited thereto.
  • one or more cosmetically acceptable carriers to be blended with general skin cosmetics, and for example, oil, water, surfactant, moisturizing agent, lower alcohol, Thickeners, chelating agents, pigments, preservatives, fragrances, etc. may be appropriately blended, but are not limited thereto.
  • the cosmetically acceptable carrier included in the cosmetic composition of the present invention varies depending on the formulation.
  • the formulation of the present invention is an ointment, paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc, zinc oxide or Mixtures of these can be used.
  • lactose, talc, silica, aluminum hydroxide, calcium silicate, polyamide powder or a mixture thereof can be used as a carrier component, especially in the case of a spray, additional chloro And propellants such as fluorohydrocarbon, propane/butane or dimethyl ether.
  • a solvent, solubilizing agent or emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-Butyl glycol oil can be used, in particular cottonseed oil, peanut oil, corn seed oil, olive oil, castor oil and sesame oil, glycerol aliphatic esters, polyethylene glycol or fatty acid esters of sorbitan. have.
  • liquid diluents such as water, ethanol or propylene glycol as carrier components
  • suspensions such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, micro Crystalline cellulose, aluminum metahydroxide, bentonite, agar or trakant, etc. can be used.
  • the formulation of the present invention is a soap, alkali metal salt of fatty acid, fatty acid hemiester salt, fatty acid protein hydrolyzate, isethionate, lanolin derivative, aliphatic alcohol, vegetable oil, glycerol, sugar, etc. may be used as a carrier component.
  • a soap alkali metal salt of fatty acid, fatty acid hemiester salt, fatty acid protein hydrolyzate, isethionate, lanolin derivative, aliphatic alcohol, vegetable oil, glycerol, sugar, etc.
  • the present invention provides a food composition for moisturizing the skin, which includes thyme extract, machihyeon extract, coriander extract, and Eoseongcho extract as active ingredients.
  • thyme extract of the present invention Machi Prefecture extract, Cypress extract, and Eoseongcho extract, and skin moisturizing are as described above.
  • the food composition may be used in the form of a health functional food, but is not limited thereto.
  • composition may include a food additive that is food-pharmaceutically acceptable in addition to the active ingredient.
  • food supplement additive means a component that can be supplementally added to food, and is added to prepare a health functional food of each formulation, and can be appropriately selected and used by those skilled in the art.
  • food supplements include flavors such as various nutrients, vitamins, minerals (electrolytes), synthetic flavors and natural flavors, colorants and fillers, pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloidal thickeners , pH adjusting agents, stabilizers, preservatives, glycerin, alcohol, carbonic acid used in carbonated beverages, and the like, but the types of food supplements of the present invention are not limited by the examples.
  • the food composition of the present invention may include a health functional food.
  • health functional food refers to food prepared and processed in the form of tablets, capsules, powders, granules, liquids and pills, etc. using ingredients or ingredients having useful functionality for the human body.
  • functional means to obtain a useful effect for health purposes such as nutrient control or physiological action on the structure and function of the human body.
  • the health functional food of the present invention can be manufactured by a method commonly used in the art, and in the preparation, it can be prepared by adding raw materials and ingredients that are conventionally added in the art.
  • the formulation of the health functional food can also be prepared without limitation as long as the formulation is recognized as a health functional food.
  • the food composition of the present invention can be manufactured in various types of formulations, and has the advantage of not having side effects that may occur when taking the drug for a long time using food as a raw material, unlike general drugs, and has excellent portability.
  • Health functional foods can be taken as supplements to enhance the skin moisturizing effect.
  • the health functional food of the present invention can take, and may include all foods in a common sense, and can be mixed with terms known in the art, such as functional food.
  • the health functional food of the present invention can be prepared by mixing other appropriate ingredients and known additives that may be included in the food according to the choice of those skilled in the art. Examples of foods that can be added include meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen, other noodles, gums, dairy products including ice cream, various soups, beverages, tea, drinks, alcoholic beverages and There are vitamin complexes, etc., and can be prepared by adding the compound represented by Chemical Formula 1 according to the present invention as a main component to juice, tea, jelly, and juice. It also includes food used as feed for animals.
  • the present invention provides a quasi-drug composition for moisturizing the skin, including thyme extract, machihyeon extract, centella extract, and Eoseongcho extract as active ingredients.
  • thyme extract of the present invention, machihyeon extract, jugyun extract, and Eoseongcho extract, and skin moisturizing are as described above.
  • the quasi-drug composition of the present invention may further include a pharmaceutically acceptable carrier, excipient, or diluent as needed in addition to the above components.
  • a pharmaceutically acceptable carrier, excipient or diluent is not limited as long as the effects of the present invention are not impaired, for example, fillers, extenders, binders, wetting agents, disintegrating agents, surfactants, lubricants, sweeteners, fragrances, preservatives, etc. It can contain.
  • Representative examples of pharmaceutically acceptable carriers, excipients or diluents of the present invention include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, maltitol, starch, gelatin, glycerin, acacia rubber, alginate, calcium phosphate, calcium Carbonate, calcium silicate, cellulose, methyl cellulose, microcrystalline cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate, mineral oil, propylene glycol, polyethylene glycol, vegetable oil , Injectable ester, witepsol, macrogol, twin 61, cacao butter, laurid, and the like.
  • machihyeon extract, bottleweed extract, and Eoseongcho extract when used as a quasi-drug extract of the present invention, it may further contain one or more active ingredients exhibiting the same or similar functions.
  • it may contain known moisturizing ingredients.
  • additional moisturizing ingredients can further increase the moisturizing effect of the compositions of the present invention.
  • skin safety, ease of formulation, and stability of active ingredients according to the combined use may be considered.
  • the quasi-drug composition is a moisturizing ingredient known in the art, retinol acid, TGF, animal placenta-derived protein, betulinic acid and chlorella extract; And one or two or more components selected from the group consisting of these derivatives and various plant extracts.
  • Additional components may be included in 0.001% to 10% by weight relative to the total composition weight, the content range is skin safety, time extract of the present invention, Machihyeon extract, ease of the formulation of the extract, and Eoseongcho extract, etc. It can be adjusted according to the requirements of.
  • the quasi-drug composition of the present invention may include, but is not limited to, disinfectant cleaners, shower foams, ointments, wipes, coatings, and the like, and formulation methods, dosages, methods of use, and components of quasi-drugs are commonly known in the art. It can be appropriately selected from the technology.
  • the thyme extract of the present invention Machihyeon extract, Cypress extract, and Eoseongcho extract can be used in the method of skin moisturizing, including the step of applying to the skin of an individual.
  • the subject includes, without limitation, mammals, including rats, livestock, and humans.
  • the present invention provides a composition for moisturizing the skin, including thyme extract, machihyeon extract, centella extract, and Eoseongcho extract as active ingredients.
  • composition for moisturizing the skin of the present invention has excellent moisturizing effect by promoting the expression of Filaggrin and Hyaluronic acid genes, it is usefully used for moisturizing skin in cosmetics, food, and quasi-drugs. It is possible.
  • composition of the present invention is not only very safe for the human body, but also excellent in stability.
  • HaCaT human keratinocytes
  • Figure 2 is a graph showing by measuring the change in the amount of production of hyaluronic acid after treatment with human keratinocytes, respectively, thyme extract, Machi Prefecture extract, Cypress extract, and Eoseongcho extract alone.
  • Figure 3 is a graph showing by measuring the change in the amount of production of hyaluronic acid after treating the complex extracts of thyme, machihyeon, yelp, and Eoseongcho with different combination ratios to human keratinocytes.
  • Figure 4 is a graph showing by measuring the change in the amount of production of hyaluronic acid after treating the complex extract of thyme, machihyeon, yelp, and Eoseongcho by varying the combination ratio.
  • FIG. 5 is a graph showing the expression level of a moisturizing-related gene after treating a complex extract (4:1:3:1 weight ratio) of thyme, machihyeon, medicinal herb, and Eoseongcho to human keratinocytes.
  • HaCaT human keratinocytes
  • DMEM Dulbeccos modified Eagles medium
  • DMEM Dulbeccos modified Eagles medium
  • fetal bovine serum Cambrex
  • the medium was removed and diluted with serum-free DMEM medium to treat the thyme, marchi, coleoptera, and Eoseongcho extracts prepared in Example 1 by concentration (10, 50, and 100 ⁇ g/mL) for 24 hours.
  • 1 mg/mL of MTT was treated and after 2 hours, formazan produced by MTT treatment was dissolved in DMSO with DMSO to measure absorbance at 570 nm.
  • Human keratinocytes were inoculated at a concentration of about 1 ⁇ 10 5 in a 1 ml culture solution in a 24 well cell culture dish, and cultured for 24 hours in a 37° C., 5% CO 2 environment. Subsequently, the medium prepared in Example 1 was replaced with a medium containing thyme, marchi string, coriander, and Eoseongcho extracts (10, 50, and 100 ⁇ g/ml) and cultured for 24 hours.
  • Hyaluronan Hyaluronan kit, R&D Systems, Inc., Minneapolis, MN, USA
  • Hyaluronan kit R&D Systems, Inc., Minneapolis, MN, USA
  • Hyaluronic acid (HA, Hyaluronan, Hyaluronic acid) is mainly synthesized by epidermal keratinocytes and dermal fibroblasts, and is a substance that plays an important role in creating an environment in which cells can function normally by combining with moisture.
  • the reduction of hyaluronic acid in the skin is one of the direct causes of decreased skin elasticity and decreased water content. Therefore, in this experimental example, the amount of hyaluronic acid produced in human keratinocytes was confirmed.
  • Hyaluronic acid (Hyaluronan) synthesis changes were measured in the same manner as in Example 3-1, but the effect of these complex extracts was verified by combining thyme, machihyeon, beeful, and eoseongcho.
  • the complex extracts were used at concentrations of 10, 50, and 100 ⁇ g/ml, and the median ratio between the used plant extracts is shown in Table 1 below.
  • Example 3 the composite extract of Experimental Example 6, which showed that hyaluronic acid (Hyaluronan) production promoting effect was the best, was obtained by Filaggrin (FLG, stratum corneum forming factor) and Hyaluronan synthase-3 (HAS-3, skin moisturizing factor). The effect on gene expression was tested.
  • Filaggrin FLG, stratum corneum forming factor
  • HAS-3 Hyaluronan synthase-3
  • human keratinocytes were inoculated at a concentration of 1 ⁇ 10 6 cells in DMEM medium containing 10% FBS in a 100 mm cell culture dish, and cultured in a 37° C., 5% CO 2 incubator for 24 hours. Incubated for 24 hours, the extracts of Experimental Example 6 were diluted in DMEM medium so as to have concentrations of 50 ⁇ g/mL and 100 ⁇ g/mL, respectively, and the diluted solution prepared was added and cultured for 24 hours under the same conditions. Thereafter, cells were recovered using Trizol reagent (invitrogen, USA) to isolate RNA. Using the RT-PCR method, mRNA expression levels of Filaggrin and hyaluronan synthase-3 were confirmed. The primers used were:
  • Filaggrin exists in the form of profilaggrin, a protein that forms keratohialin granules in the epidermal granular layer, and then forms a keratinocyte membrane after it is degraded into filaggrin in the final differentiation process of keratinocytes.
  • the keratin filaments are aggregated to form a hard and flat structure of keratinocytes, it acts as a brick in the skin barrier.
  • hyaluronic acid (HA, Hyaluronan, Hyaluronic acid) is a component in the form of a carbohydrate and plays an important role in creating an environment in which cells can function normally by combining with moisture in the dermis and epidermis.
  • Hyaluronic acid one of the bioactive substances present in the dermal layer and epidermis, is a substance synthesized in fibroblasts and produced by hyaluronic acid synthase.
  • mRNA expression of pilargreen and hyaluronic acid synthase was confirmed in human keratinocytes directly related to skin moisturization.
  • the mRNA expression levels of filaggrin were respectively It was increased by 389.5% (50 ⁇ g/mL) and 607.1% (100 ⁇ g/mL), and mRNA expression levels of hyaluronan synthase-3 increased by 30.5% (50 ⁇ g/mL) and 46.2% (100 ⁇ g/mL), respectively.
  • the complex extract-treated group of Experimental Example 6 in which the thyme, marchi string, coleoptera, and Eoseongcho were mixed at a ratio of 4:1:3:1, the mRNA expression levels of filaggrin were respectively It was increased by 389.5% (50 ⁇ g/mL) and 607.1% (100 ⁇ g/mL), and mRNA expression levels of hyaluronan synthase-3 increased by 30.5% (50 ⁇ g/mL)
  • the composition for moisturizing the skin comprising the extract of thyme, marchi string, coriander, and Eoseongcho of the present invention has no cytotoxicity and has an effect of improving skin moisturizing by increasing keratin formation and synthesis of hyaluronic acid.
  • the highest synergistic effect on moisturizing the skin was found in a complex extract in which thyme, machihyeon, yelp, and Eoseongcho were mixed in a ratio of 4:1:3:1.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • Botany (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Microbiology (AREA)
  • Nutrition Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

La présente invention concerne une composition cosmétique comprenant un extrait de Thymus vulgaris, un extrait de Portulaca oleracea, un extrait de Centella asiatica et un extrait de Houttuynia cordata en tant que principes actifs pour hydrater la peau. La composition hydratante pour la peau de la présente invention stimule l'expression des gènes de la filaggrine et de l'acide hyaluronique et présente un excellent effet hydratant et, en tant que telle, peut être avantageusement utilisée pour l'hydratation de la peau dans le domaine des cosmétiques, des produits alimentaires et des quasi-médicaments. De plus, la composition de la présente invention est très sûre pour le corps humain ainsi que d'une stabilité très remarquable.
PCT/KR2018/014751 2018-11-28 2018-11-28 Composition cosmétique comprenant comme principe actif un extrait composite à base de thym pour hydrater la peau Ceased WO2020111297A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/KR2018/014751 WO2020111297A1 (fr) 2018-11-28 2018-11-28 Composition cosmétique comprenant comme principe actif un extrait composite à base de thym pour hydrater la peau
CN201880096652.6A CN112584820A (zh) 2018-11-28 2018-11-28 含有百里香复合提取物作为有效成分的皮肤保湿用化妆品组合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/KR2018/014751 WO2020111297A1 (fr) 2018-11-28 2018-11-28 Composition cosmétique comprenant comme principe actif un extrait composite à base de thym pour hydrater la peau

Publications (1)

Publication Number Publication Date
WO2020111297A1 true WO2020111297A1 (fr) 2020-06-04

Family

ID=70853299

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2018/014751 Ceased WO2020111297A1 (fr) 2018-11-28 2018-11-28 Composition cosmétique comprenant comme principe actif un extrait composite à base de thym pour hydrater la peau

Country Status (2)

Country Link
CN (1) CN112584820A (fr)
WO (1) WO2020111297A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112842947A (zh) * 2019-11-26 2021-05-28 上海家化联合股份有限公司 鱼腥草提取物及其在皮肤外用剂中的应用
CN117084949A (zh) * 2023-09-28 2023-11-21 绽妍生物科技有限公司 一种具有肌肤屏障修复作用的物理防晒组合物及其制备方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119074620B (zh) * 2024-10-11 2025-07-04 云南贝泰妮生物科技集团股份有限公司 一种具有保湿抗敏功效的组合物及其应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10130162A (ja) * 1996-10-31 1998-05-19 Kanebo Ltd ヒアルロン酸分解阻害剤、ヒアルロン酸異常分解疾患治療剤および化粧料
JP2002265327A (ja) * 2001-03-13 2002-09-18 Chifure Keshohin:Kk 化粧料
KR20110000082A (ko) * 2009-06-26 2011-01-03 주식회사 한생화장품 여드름 개선을 위한 화장료 조성물
KR20160054673A (ko) * 2014-11-06 2016-05-17 주식회사 엘지생활건강 마치현 추출물을 포함하는 히알루론산 생성 촉진용 조성물과 이의 이용
KR20170050062A (ko) * 2015-10-29 2017-05-11 최경석 병풀로부터 분리한 아시아티코사이드, 마데카소사이드, 아시아틱산 및 마데카식산을 포함하는 음료 및 화장료 조성물 및 그 제조방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008105985A (ja) * 2006-10-25 2008-05-08 Nicca Chemical Co Ltd ヒアルロン酸産生促進剤、皮膚外用剤、浴用剤及び飲食物
CN104519894B (zh) * 2012-08-10 2018-11-09 株式会社资生堂 丝聚蛋白基因表达促进剂
WO2017034367A2 (fr) * 2015-08-27 2017-03-02 주식회사 엘지생활건강 Composition de modification de surface
CN105769698B (zh) * 2016-04-14 2019-08-23 曼秀雷敦(中国)药业有限公司 一种不含防腐剂的化妆品组合物及其应用
KR102500924B1 (ko) * 2016-08-04 2023-02-21 주식회사 두래 보습 효능을 갖는 유아용 화장료 조성물
CN108379168B (zh) * 2018-05-03 2021-03-30 杜铭 一种植物修复角质层的化妆品及其制备方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10130162A (ja) * 1996-10-31 1998-05-19 Kanebo Ltd ヒアルロン酸分解阻害剤、ヒアルロン酸異常分解疾患治療剤および化粧料
JP2002265327A (ja) * 2001-03-13 2002-09-18 Chifure Keshohin:Kk 化粧料
KR20110000082A (ko) * 2009-06-26 2011-01-03 주식회사 한생화장품 여드름 개선을 위한 화장료 조성물
KR20160054673A (ko) * 2014-11-06 2016-05-17 주식회사 엘지생활건강 마치현 추출물을 포함하는 히알루론산 생성 촉진용 조성물과 이의 이용
KR20170050062A (ko) * 2015-10-29 2017-05-11 최경석 병풀로부터 분리한 아시아티코사이드, 마데카소사이드, 아시아틱산 및 마데카식산을 포함하는 음료 및 화장료 조성물 및 그 제조방법

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112842947A (zh) * 2019-11-26 2021-05-28 上海家化联合股份有限公司 鱼腥草提取物及其在皮肤外用剂中的应用
CN117084949A (zh) * 2023-09-28 2023-11-21 绽妍生物科技有限公司 一种具有肌肤屏障修复作用的物理防晒组合物及其制备方法

Also Published As

Publication number Publication date
CN112584820A (zh) 2021-03-30

Similar Documents

Publication Publication Date Title
WO2020060060A1 (fr) Composition cosmétique comprenant un extrait de racine adventive de centella asiatica en tant que principe actif pour le blanchiment de la peau et la réduction des rides
KR102126470B1 (ko) 용안육 추출물을 포함하는 화장료 조성물
WO2018004252A1 (fr) Composition pour activer la croissance des poils ou inhiber la chute des poils utilisant un extrait de feuille de rosmarinus officinalis (romarin)
KR20180119550A (ko) 침향 추출물을 포함하는 피부 보습용 화장료 조성물
WO2020111297A1 (fr) Composition cosmétique comprenant comme principe actif un extrait composite à base de thym pour hydrater la peau
WO2023132415A1 (fr) Composition pour la réduction des rides de la peau, l'hydratation, l'amélioration de la barrière cutanée et la régénération de la peau, comprenant une souche complexe de bactéries lactiques en tant que principe actif
KR101758144B1 (ko) 이고들빼기 추출물을 포함하는 항노화 조성물
JP6709783B2 (ja) アルパインワームウッド抽出物を含む脱毛防止または育毛促進用組成物
KR102178890B1 (ko) 마치현 추출물을 포함하는 히알루론산 생성 촉진용 조성물과 이의 이용
KR20150086681A (ko) 히드록시 피라논 유도체 화합물을 포함하는 지방세포 분화 촉진용 화장료 조성물
KR102326086B1 (ko) 닥나무 복합 추출물을 유효성분으로 포함하는 피부 미백, 주름개선, 보습, 및 피부장벽 강화용 조성물
KR101997881B1 (ko) 타임 복합 추출물을 유효성분으로 함유하는 피부 보습용 화장료 조성물
KR101541470B1 (ko) 진세노사이드 ｆ2를 포함하는 탈모방지 또는 발모촉진용 조성물
KR102008485B1 (ko) 침향 추출물을 포함하는 피부 보습용 화장료 조성물
KR101824497B1 (ko) 피토에스트로겐을 유효성분으로 포함하는 탈모방지 및 모발 성장 촉진용 조성물
KR101967922B1 (ko) 무궁화 추출물을 유효성분으로 함유하는 피부 보습용 화장료 조성물
KR102114133B1 (ko) 알피나 골무꽃 추출물을 포함하는 탈모 방지 또는 육모 촉진용 조성물
US20170135948A1 (en) Composition comprising extract of autumn soybean leaves
WO2020091295A1 (fr) Composition comprenant un extrait d'écorce d'ailanthus altissima en tant que principe actif pour le soin de la peau acnéique ou l'inhibition de la sécrétion de sébum
KR20230126690A (ko) 피부건조증의 예방 또는 치료용 조성물
KR102182710B1 (ko) 장미허브 추출물, 또는 이의 복합 추출물을 유효성분으로 함유하는 피부 보습용 조성물
KR102105672B1 (ko) 용안육 추출물을 포함하는 화장료 조성물
US11090351B2 (en) Whitening agent
WO2016003120A1 (fr) Composition de blanchiment comprenant un extrait de scutellaria alpina
KR101273027B1 (ko) 캄페롤을 유효성분으로 함유하는 피지 분비 억제용 및항비만용 조성물

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18941789

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO FORM 1205A DATED 06.10.2021)

122 Ep: pct application non-entry in european phase

Ref document number: 18941789

Country of ref document: EP

Kind code of ref document: A1