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WO2018107821A1 - Peau bionique et procédé de préparation associé - Google Patents

Peau bionique et procédé de préparation associé Download PDF

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Publication number
WO2018107821A1
WO2018107821A1 PCT/CN2017/100138 CN2017100138W WO2018107821A1 WO 2018107821 A1 WO2018107821 A1 WO 2018107821A1 CN 2017100138 W CN2017100138 W CN 2017100138W WO 2018107821 A1 WO2018107821 A1 WO 2018107821A1
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Prior art keywords
product
parts
polydimethylsiloxane
reaction liquid
skin
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2017/100138
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English (en)
Chinese (zh)
Inventor
姜舒
张芸
纪惜銮
罗朝霞
杨顺
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shenzhen Wingor Biotechnology Co ltd
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Shenzhen Wingor Biotechnology Co ltd
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Publication of WO2018107821A1 publication Critical patent/WO2018107821A1/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
    • A61K8/585—Organosilicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/88—Polyamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Definitions

  • the present invention relates to the field of cosmetics, and in particular to a biomimetic skin and a preparation method thereof.
  • the skin is one of the most important organs of the human body. It is a barrier between the human body and the outside world. It protects human tissues and organs from toxic substances, pathogens and microorganisms in the external environment, thus maintaining the stability of the internal environment. It has good permeability and moisture retention, and the physiological state of the skin reflects the individual's health. senescence
  • Biosafety high biocompatibility, application to the skin is not sensitized, does not produce Inflammatory reaction
  • Appropriate viscosity easy to apply on the skin surface, easy to form a film
  • Breathable and moisturizing and waterproof blocking the harmful factors of the external environment
  • biomechanical properties of normal skin such as tensile strength and elasticity, Matches the mechanical response of the skin in daily activities
  • Smooth and thin, good optical effect adhered to the normal skin surface, no obvious connection interface, to achieve an aesthetic effect.
  • existing artificial skin still does not fully possess the functional and physiological properties of natural skin.
  • the present invention is achieved by: a bionic skin comprising a base reactant, an adjuvant and water
  • the emulsion polymerization occurs under the catalytic action of the catalyst to form a crosslinked network structure; wherein the basic reactant accounts for 10-20% of the total mass of the reactant, and the auxiliary agent accounts for 40-55% of the total mass of the reactant, and the rest Is water;
  • the base reactant comprises 47-60 parts of vinyl-terminated polydimethylsiloxane, 20-29 parts of fumed silica and 17-36 parts of active hydrogen-containing polysiloxane;
  • the catalyst is a Karstedt platinum catalyst, and the platinum content of the catalyst is 1-5%;
  • the auxiliary agent includes a viscosity reducing agent for reducing the stickiness of the product, an emulsifier for increasing the degree of emulsification of the product, and a moisturizing agent for increasing the surface moisture of the skin.
  • the viscosity reducing agent comprises polydimethylsiloxane One or both of an alkane and a trisiloxane, a polydimethylsiloxane;
  • the emulsifier comprises a polydimethylsiloxane/PEG-10/15 crosslinked polymer and a decamethylcyclopentane Silicone, diisobutyl PEG/PPG-10/7/polydimethylsiloxane One or two of the polymers;
  • the humectant includes phenoxyethanol, a diol mixture of pentanediol and octylene glycol 1:1, one or more of propylene glycol, butylene glycol, and glycerin;
  • the pH adjusting agent is sodium
  • the artificial skin provided by the present solution is safe and reliable, and the existing literature records indicate that the formulation components involved in the invention have safety and biocompatibility, and are not sensitized and inflammatory.
  • polydimethylsiloxane and trisiloxane refers to a material instead of “polydimethylsiloxane” and “trisiloxane”. Alkane "two materials.
  • polydimethylsiloxane/PEG-1 0/15 crosslinked polymer and decamethylcyclopentasiloxane, decamethylcyclopentasiloxane and polydimethylsiloxane polymer, poly The dimethylsiloxane crosslinked copolymer and cyclopentamethylsiloxane also refer to one substance, respectively.
  • the vinyl terminated polydimethylsiloxane is a mixture of Andisil VS200 product and VS 10 product; the active hydrogen group-containing polysiloxane is Andisil XL-11 product; the Karstedt platinum catalyst is a product of AB Specialty Silicones; the polydimethylsiloxane and trisiloxane are products of Dow Corning Corporation PMX-1184; the polydimethylsiloxane Dow Corning Corporation PMX-200 product; the polydimethylsiloxane/PEG-10/15 crosslinked polymer and decamethylcyclopentasiloxane are Shin-Etsu Chemical Corporation KSG-240 products; Isobutyl PEG/PPG-10/7/polydimethylsiloxane copolymer is Dow Corning Corporation FZ-2233 product; acrylate/C10-30 alkyl acrylate crosspolymer is Lubrizol
  • the same Chinese chemical name may correspond to two different specific products.
  • the "vinyl-terminated polydimethylsiloxane plant" in this scheme uses Andisil Company respectively.
  • Both the V S200 and VS10 products, which are vinyl-terminated polydimethylsiloxanes, have different vinyl contents and therefore have different viscosities that affect the properties of the artificial skin provided by this solution.
  • Another object of the present invention is to provide a method for preparing bionic skin.
  • the method includes the following steps,
  • Step A preparing a first reaction liquid;
  • the first reaction liquid comprises a homogeneously mixed base reactant, water and an auxiliary agent; wherein the basic reactant accounts for 25-36% of the total mass of the first reaction liquid, The auxiliary agent accounts for 15-25% of the total mass of the first reaction liquid, and the balance is water;
  • the base reactant comprises 47-60 parts of vinyl-terminated polydimethylsiloxane, 20-29 parts of gas phase method Silica and 17-36 parts of active hydrogen group-containing polysiloxane;
  • Step B preparing a second reaction liquid;
  • the second reaction liquid comprises a uniformly mixed catalyst, water and a solvent; wherein the catalyst mass accounts for 0.5-3% of the total mass of the second reaction liquid, The auxiliary agent accounts for 60-80% of the total mass of the second reaction liquid, and the balance is water;
  • the catalyst is a Karstedt platinum catalyst, and the platinum content of the catalyst is 1-5%;
  • Step C applying the first reaction solution to the skin
  • Step D applying the second reaction solution to the area of the step C in which the first reaction liquid is applied,
  • the reaction forms artificial skin;
  • the second reaction solution has a smear mass of 1-2 times that of the first reaction solution.
  • step A includes the following sub-steps,
  • Step A1 preparing a main reaction solution; the main reaction solution is obtained by uniformly mixing a base reactant, a viscosity reducer for reducing the stickiness of the product, and an emulsifier for increasing the degree of emulsification of the product; Includes 7-10 parts of Andisil's vinyl terminated polydimethylsiloxane VS
  • Step A2 preparing a diluted solution: the diluted solution is obtained by uniformly mixing a thickener, a moisturizer that increases the surface moisture of the skin, and water;
  • Step A3 preparing a first reaction liquid; the first reaction liquid is formed by slowly adding the diluted solution to the main reaction solution until a white creamy emulsion is formed.
  • a further technical solution of the present invention is:
  • the step A further comprises the substep A4: adding a pH adjuster and adjusting the first reaction solution to a pH of 5.5-6.6.
  • the pH can be adjusted by a 10N sodium hydroxide solution.
  • step B includes the following sub-steps
  • Step B1 preparing a thickening solution formed by uniformly mixing a thickener which increases the viscosity of the product, a spreading agent for improving the spreading property of the product, and an emulsifier which increases the degree of emulsification of the product;
  • Step B2 preparing a moisturizing solution composed of water and a moisturizing agent that increases the surface moisture of the skin;
  • Step B3 preparing a second reaction liquid; the second reaction liquid is obtained by slowly adding the moisturizing solution to the thickening solution until a clear emulsion is formed, and then adding a catalyst.
  • a further technical solution of the present invention is: adding 3-7 parts of a beautifying agent for enhancing product dispersibility and improving aesthetic effect before adding the catalyst in the step B3;
  • the beautifying agent is isopropyl triisostearate Oxygen titanium salt modified nylon.
  • the viscosity reducing agent comprises 10-14 parts of Dow Coming Corporation polydimethylsiloxane and trisiloxane PMX-1184 product, Dow Coming Corporation polydimethyl Silicone PMX-200 product 1-5 parts;
  • the emulsifier includes Shin-Etsu Chemical Corporation polydimethylsiloxane/PEG-10/15 crosslinked polymer and decamethylcyclopentasiloxane KSG - 240 products 3-7 parts, Dow Corning Corporation diisobutyl PEG/PPG-10/7/polydimethylsiloxane copolymer FZ-2233 product 0.05-0.3 parts;
  • the thickener includes Lubrizol Corporation 0.1-0.7 parts of acrylate/C10-30 alkyl acrylate cross-linked polymer Pemulen TR-2, Lubrizol Corporation acrylate/C10-30 alkyl acrylate cross-linked polymer Ultrez 20 product 0.1-0.7 parts
  • the humectant comprises 0.1-0.5 parts of
  • the thickener comprises 8-13 parts of Dow Coming Corporation's decamethylcyclopentasiloxane and polydimethylsiloxane polymer DC9045 product, Dow Corning Corporation Polydimethylsiloxane cross-linking copolymer and 1-5 parts of cyclopentamethylsiloxane DC9040 product, 0.3-0.7 parts of sodium chloride;
  • the spreading agent includes ring-polydimethylene of Shin-Etsu Chemical Corporation 13-18 parts of the base silicone KF-995 product, 0.1-3 parts of the cyclopentadimethylsiloxane PMX-0245 product of Dow Corning Corporation;
  • the humectant includes 0.1-0.7 parts of phenoxyethanol, 3-7 parts of a diol mixture of alcohol and octylene glycol 1:1, 8-13 parts of propylene glycol, 8-13 parts of butanediol, and 3-8 parts of glycerin;
  • the emulsifier includes Shin
  • the beneficial effects of the present invention are:
  • the first reaction liquid in the solution can be closely adhered to the skin, and after the second reaction liquid is applied, the silicone component can be crosslinked under the action of the platinum catalyst to form a strong network structure.
  • the bionic skin cosmetics formed are washable and waterproof, and have the biomechanical properties of normal skin. The only need to directly remove the cockroaches is to remove the cockroaches, which is convenient and safe, and is quick to prepare.
  • the program has the following advantages: 1) The existing literature records indicate that the formulation components involved in the invention have safety and biocompatibility, no sensitization and inflammation; 2) suitable viscosity, easy to spread evenly on the skin surface, easy Film formation; 3) good biomechanical properties, such as tensile modulus, adhesion, shrinkage, etc.; 4) good breathability and moisturizing properties, washable and waterproof, can block the harmful factors of the outside; 5) preparation of the patented method of the present invention
  • the surface of the bionic skin is smooth and only 75 microns thick.
  • the added NylonlO-12 has good optical effect, which can make the bionic skin perfectly combine with the human skin surface without obvious connecting lines.
  • the bionic skin prepared by the method of the invention can be applied to human skin to make the skin smooth and elastic, and less Light wrinkles.
  • the present invention firstly provides a biomimetic skin, which is formed by emulsion polymerization of a base reactant, an auxiliary agent and water under the catalytic action of a catalyst to form a crosslinked network structure; wherein the base reactant accounts for 10-20% of the total mass of the reactants, the adjuvant is 40-55% of the total mass of the reactants, the balance being water; the base reactant comprises 47-60 parts of vinyl terminated polydimethylsiloxane 20-29 parts of fumed silica and 17-36 parts of active hydrogen group-containing polysiloxane; the catalyst is a Karstedt platinum catalyst, and the catalyst has a platinum content of 1-5%;
  • the agent includes a viscosity reducing agent for reducing the stickiness of the product, an emulsifier for increasing the degree of emulsification of the product, a moisturizing agent for increasing the surface moisture of the skin, a pH adjuster for adjusting the pH of the product, a thickener for increasing the visco
  • the viscosity reducing agent comprising one or both of polydimethylsiloxane and trisiloxane, polydimethylsiloxane;
  • Emulsifiers include polydimethylsiloxane/PE One or both of G-10/15 crosslinked polymer and decamethylcyclopentasiloxane, diisobutyl PEG/PPG-10/7/polydimethylsiloxane copolymer;
  • the humectant comprises a mixture of phenoxyethanol, pentanediol and octylene glycol 1:1, a propylene glycol, a butanediol, a glycerin;
  • the pH adjuster is sodium hydroxide;
  • Thickeners include acrylate/C10-30 alkyl acrylate crosspolymer, decamethylcyclopentasiloxane and polydimethylsiloxane a polymer, a polyd
  • the artificial skin provided by the present solution is safe and reliable, and the existing literature records indicate that the formulation components of the present invention have safety and biocompatibility, and are not sensitized and inflammatory.
  • polydimethylsiloxane and trisiloxane refers to a material instead of “polydimethylsiloxane” and “trisiloxane”. Alkane "two materials.
  • polydimethylsiloxane/PEG-1 0/15 crosslinked polymer and decamethylcyclopentasiloxane, decamethylcyclopentasiloxane and polydimethylsiloxane polymer, poly The dimethylsiloxane crosslinked copolymer and cyclopentamethylsiloxane also refer to one substance, respectively.
  • the vinyl terminated polydimethylsiloxane is a mixture of Andisil VS200 product and VS10 product; the active hydrogen group-containing polysiloxane is Andisil XL-11 product;
  • the Karst edt platinum catalyst is a product of AB Specialty Silicones;
  • the polydimethylsiloxane and trisiloxane are products of Dow Corning Corporation PMX-1184;
  • the polydimethylsiloxane is Dow Coming Corporation PMX-200 product;
  • the polydimethylsiloxane/PEG-10/15 crosslinked polymer and decamethylcyclopentasiloxane are products of Shin-Etsu Chemical Corporation KSG-240; PEG/PPG-10/7/polydimethylsiloxane copolymer for Dow Corning
  • acrylate/C 10-30 alkyl acrylate crosspolymer is a mixture of Lubri zol Corporation Pemulen TR-2 product and Ultrez 20 product; the decamethylcyclopentasiloxane and The polydimethylsiloxane polymer is a Dow Corning Corporation DC9045 product; the polydimethylsiloxane crosslinked copolymer and cyclopentamethylsiloxane are Dow Corning
  • the present invention also discloses a method of producing bionic skin.
  • the method includes the following steps,
  • Step A preparing a first reaction liquid; the first reaction liquid includes a homogeneously mixed base reactant, water And an auxiliary agent; wherein the basic reactant accounts for 25-36% of the total mass of the first reaction liquid, the auxiliary agent accounts for 15-25% of the total mass of the first reaction liquid, and the rest is water; the basic reactant includes 47-60 parts of vinyl-terminated polydimethylsiloxane, 20-29 parts of fumed silica, and 17-36 parts of active hydrogen-containing polysiloxane; [0041] Step A includes the following Step by step,
  • Step A1 preparing a main reaction solution; the main reaction solution is obtained by uniformly mixing a base reactant, a viscosity reducer for reducing the stickiness of the product, and an emulsifier for increasing the degree of emulsification of the product; Includes 7-10 parts of Andisil's vinyl terminated polydimethylsiloxane VS
  • Step A2 preparing a diluted solution: the diluted solution is obtained by uniformly mixing a thickener, a moisturizer that increases the surface moisture of the skin, and water;
  • Step A3 preparing a first reaction liquid; the first reaction liquid is formed by slowly adding the diluted solution to the main reaction solution until a white creamy emulsion is formed.
  • Step A4 A pH adjuster is added and the first reaction solution is adjusted to a pH of 5.5-6.6.
  • the pH can be adjusted by a 10N sodium hydroxide solution.
  • the viscosity reducing agent comprises Dow Corning Corporation polydimethylsiloxane and trisiloxane PMX-1184 product 10-14 parts, Dow Coming
  • the emulsifier includes Shin-Etsu Chemical Corporation polydimethylsiloxane / PEG-10 / 15 cross-linked polymer and decamethyl 3-7 parts of cyclopentasiloxane KSG-240 product, Dow Corning Corporation diisobutyl PEG/PPG-10/7/polydimethylsiloxane copolymer FZ-2233 product 0.05-0.3 parts; Thickeners include Lubrizol Corporation acrylate/C10-30 alkyl acrylate crosspolymer PEmulen
  • the humectant includes phenoxyethanol 0.1-0.5 parts, pentylene 0.1-0.5 parts of a mixture of alcohol and octylene glycol 1:1
  • Step B preparing a second reaction liquid;
  • the second reaction liquid comprises a uniformly mixed catalyst, water and a solvent; wherein the catalyst mass accounts for 0.5-3% of the total mass of the second reaction liquid, The auxiliary agent accounts for 60-80% of the total mass of the second reaction liquid, and the balance is water;
  • the catalyst is a Karstedt platinum catalyst, the catalyst The platinum content is 1-5%;
  • the step B includes the following sub-steps,
  • Step B1 preparing a thickening solution formed by uniformly mixing a thickener which increases the viscosity of the product, a spreading agent for improving the spreading property of the product, and an emulsifier which increases the degree of emulsification of the product;
  • Step B2 preparing a moisturizing solution composed of water and a moisturizing agent that increases the surface moisture of the skin;
  • Step B3 preparing a second reaction liquid; the second reaction liquid is obtained by slowly adding the moisturizing solution to the thickening solution until a clear emulsion is formed, and then adding a catalyst.
  • a beautifying agent for enhancing product dispersibility and improving aesthetic effect are added before the catalyst is added in the step B3;
  • the beautifying agent is nylon modified with isopropoxytitanate.
  • the thickener includes 8-13 parts of Dow Corning Corporation's decamethylcyclopentasiloxane and polydimethylsiloxane polymer DC9045 product, Dow Corning Corporation polydimethylsiloxane 1-3 parts of a copolymer and a cyclopentamethylsiloxane DC9040 product, and 0.3-0.7 parts of sodium chloride;
  • the spreading agent includes a cyclopentadimethylsiloxane KF-995 product of Shin-Etsu Chemical Corporation 13- 18 parts, Dow Corning Corporation, 5-penta-dimethylsiloxane PMX-0245 product 0.1-3 parts;
  • the humectant includes phenoxyethanol 0.1-0.7 parts, pentanediol and octylene glycol 1: 1 3-7 parts of the diol mixture, 8-13 parts of propylene glycol, 8-13 parts of butanediol, and 3-8 parts of glycerin;
  • Step C applying the first reaction solution to the skin
  • Step D applying the second reaction solution to the area where the first reaction liquid is applied in the step C, and reacting to form artificial skin; the application quality of the second reaction liquid is the first reaction 1-2 times the liquid.
  • a in the mixer 31.0% of the base reactant, 12.0 ⁇ 3 ⁇ 4PMX-1184 (polydimethylsiloxane and trisiloxane), 2.0% PMX-200 (polydimethylsiloxane), 5.0% KSG-240 (polydimethylsiloxane/PEG-10/15 crosslinked polymer and decamethylcyclopentasiloxane), 0.1 ⁇ 3 ⁇ 4FZ -2233 (diisobutyl PEG/PPG-10/7/polydimethylsiloxane copolymer) Mix well.
  • step b The mixture obtained in step b was slowly added to the mixture obtained in the step a until a white creamy emulsion was formed, and 0.2% 10N sodium hydroxide solution was added thereto, and the pH was adjusted to 5.5 to 6.5.
  • DC9040 polydimethylsiloxane cross-linked copolymer and cyclopentamethylsiloxane
  • 5.0 ⁇ 3 ⁇ 4KSG-240 polydimethylsiloxane/PEG-10/15 cross-linked polymer and decamethyl Cyclopentasiloxane
  • 0.2% FZ-2233 diisobutyl PEG/PPG-10/7/polydimethylsiloxane copolymer
  • 15.0% KF-995 cyclopentadimethylsiloxane) Alkane
  • PMX-0245 cyclopentadimethylsiloxane
  • 0.5% sodium chloride 5.0% glycerol mixed evenly
  • e in the mixer 4 30.0% water, 0.3% phenoxyethanol, 5.0% diol mixture (pentylene glycol and octylene glycol, 1:1), 10.0% propylene glycol, 10.0% butanediol well mixed.
  • step f The mixture obtained in step e is slowly dropped into the mixture obtained in step d until a clear emulsion is formed, then 5.0 ⁇ 3 ⁇ 4 NylonlO-12 is slowly added to the emulsion to be homogeneously mixed, and finally 1.0% Karstedt platinum catalyst solution is added (including 2.0% platinum) and mix well.
  • the ratio of the emulsion 1 and the emulsion 2 is 2:3, the emulsion 1 is applied first, and then the emulsion 2 is applied.
  • the emulsion 1 can be closely adhered to the skin, and the silicone component is coated with the platinum catalyst after the emulsion 2 is applied. Under the action, it can be cross-linked to form a firm network structure, and the formed bionic skin cosmetics are washable and waterproof, and have the biomechanical properties of normal skin. To remove the crucible, just tear it.
  • the tensile modulus was 0.45 MPa, the strain at break was 800%, and the adhesion strength was 78 N mm -1 .
  • the tensile test showed that the tensile modulus of normal skin at 40% strain was 0.5-1.95 MPa, and the bionic skin cosmetic prepared by the method of the present invention had a tensile modulus of 0.5 MPa and a strain at break of 240%. Therefore, the artificial skin provided by this program has good elasticity.
  • the transepidermal water loss (TEWL) test showed that the TEWL of the bionic skin cosmetic prepared by the method of the present invention decreased by 20% after 24 hours of application (4.0 g/m 3 ⁇ 4, 3.2 g/m 3 ⁇ 4 before and after application for 24 hours). )
  • the artificial skin provided by the present solution has the following advantages: 1)
  • the existing literature records indicate that the formulation components of the present invention have safety and biocompatibility, and are not sensitized and inflammatory; 2 Appropriate viscosity, easy to spread on the skin surface, easy to form a film; 3) good biomechanical properties, such as tensile modulus, adhesion, shrinkage, etc.; 4) good breathability and moisturizing properties, washable and waterproof, can block the outside world Invasion of harmful factors; 5)
  • the bionic skin prepared by the patented method of the invention has a smooth surface and a thickness of only 75 ⁇ m, and the added Nylonl O-12 has a good optical effect, so that the bionic skin can be perfectly combined with the surface of the human skin without obvious connection. Boundary.
  • the bionic skin prepared by the method of the invention can be applied to human skin to make the skin smooth, elastic and wrinkle-reducing.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une peau bionique formée par la polymérisation en émulsion d'un réactif basique, d'un additif et d'eau, se produisant sous l'action catalytique d'un catalyseur pour former une structure de réseau réticulé. L'application de la peau bionique sur la peau humaine peut rendre la peau lisse et élastique, et peut réduire les rides.
PCT/CN2017/100138 2016-12-16 2017-09-01 Peau bionique et procédé de préparation associé Ceased WO2018107821A1 (fr)

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Families Citing this family (10)

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Publication number Priority date Publication date Assignee Title
CN106668937A (zh) * 2016-12-16 2017-05-17 深圳市茵冠生物科技有限公司 一种仿生皮肤及其制备方法
CN109966176A (zh) * 2017-12-28 2019-07-05 伊丽英 一种皮肤除皱组合物及其应用
CN108567997B (zh) * 2018-06-04 2021-03-09 上海其鸿新材料科技有限公司 一种高强度弹性隐形人造皮肤
CN108524330A (zh) * 2018-06-04 2018-09-14 上海其鸿新材料科技有限公司 一种弹性隐形皮肤的单组份涂布液及其制备方法
CN110559212A (zh) * 2019-10-14 2019-12-13 南京医科大学 一种聚硅氧烷保湿除皱面膜及其使用方法
JP7356335B2 (ja) * 2019-12-23 2023-10-04 花王株式会社 着色不織布の製造方法
CN115243733B (zh) * 2020-03-17 2024-11-12 株式会社资生堂 人造皮肤形成用组合物及其使用方法
CN113740491B (zh) * 2021-08-27 2025-03-25 无限极（中国）有限公司 一种用于感官评价的仿真皮肤及其制备方法
CN114010539B (zh) * 2021-10-29 2022-11-01 华中科技大学 一种美容仿生聚合物膜及其制备方法和应用
CN115177552A (zh) * 2022-07-11 2022-10-14 杭州归领医疗器械有限公司 一种即时遮皱的仿生皮肤乳霜及其制备方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1805761A (zh) * 2003-06-10 2006-07-19 莫恩里克保健股份公司 成弹性体屏障制剂
CN101862474A (zh) * 2009-09-30 2010-10-20 中国人民解放军第四军医大学 加成型颜面赝复硅橡胶及制备方法
WO2011001221A1 (fr) * 2009-07-03 2011-01-06 L'oreal Procédé cosmétique pour revêtir un matériau kératineux
US20120237461A1 (en) * 2010-08-31 2012-09-20 Betty Yu Skin compositions and methods of use thereof
CN103153279A (zh) * 2010-08-31 2013-06-12 生活实验公司 皮肤组合物及其使用方法
WO2014019840A2 (fr) * 2012-08-01 2014-02-06 Dow Corning Corporation Dispersions de silicone aqueuses et leur préparation
CN104136568A (zh) * 2011-12-21 2014-11-05 道康宁公司 亲水性有机硅凝胶粘合剂
CN106668937A (zh) * 2016-12-16 2017-05-17 深圳市茵冠生物科技有限公司 一种仿生皮肤及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105497968A (zh) * 2016-01-22 2016-04-20 贵州康琦药械有限公司 一种疤痕贴的制作方法

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1805761A (zh) * 2003-06-10 2006-07-19 莫恩里克保健股份公司 成弹性体屏障制剂
WO2011001221A1 (fr) * 2009-07-03 2011-01-06 L'oreal Procédé cosmétique pour revêtir un matériau kératineux
CN101862474A (zh) * 2009-09-30 2010-10-20 中国人民解放军第四军医大学 加成型颜面赝复硅橡胶及制备方法
US20120237461A1 (en) * 2010-08-31 2012-09-20 Betty Yu Skin compositions and methods of use thereof
CN103153279A (zh) * 2010-08-31 2013-06-12 生活实验公司 皮肤组合物及其使用方法
CN104136568A (zh) * 2011-12-21 2014-11-05 道康宁公司 亲水性有机硅凝胶粘合剂
WO2014019840A2 (fr) * 2012-08-01 2014-02-06 Dow Corning Corporation Dispersions de silicone aqueuses et leur préparation
CN106668937A (zh) * 2016-12-16 2017-05-17 深圳市茵冠生物科技有限公司 一种仿生皮肤及其制备方法

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