WO2018107821A1 - Bionic skin and preparation method therefor - Google Patents

Abstract

A bionic skin, the bionic skin being formed by means of emulsion polymerization of a basic reactant, an additive and water, which occurs under the catalytic action of a catalyst to form a cross-linked network structure. Applying the bionic skin to human skin may cause the skin to be smooth and elastic, and may reduce wrinkles.

Description

 Bionic skin and preparation method thereof

 [0001] The present invention relates to the field of cosmetics, and in particular to a biomimetic skin and a preparation method thereof.

 Background technique

 [0002] With the advancement of technology, people's quality of life is getting higher and higher. People's pursuit of beauty, especially the pursuit of their own beauty is getting stronger and stronger.

 [0003] The skin is one of the most important organs of the human body. It is a barrier between the human body and the outside world. It protects human tissues and organs from toxic substances, pathogens and microorganisms in the external environment, thus maintaining the stability of the internal environment. It has good permeability and moisture retention, and the physiological state of the skin reflects the individual's health. senescence

External environmental aggression, diseases, etc. can cause normal physiological dysfunction of the skin, which in turn leads to a decline in quality of life and mood disorders. Skin aging is a problem that everyone faces. The aging causes the skin to lose its elastic retraction function and becomes slack. There is still no cure.

[0004] For this reason, tissue engineering has gradually developed artificial bionic skin in recent years. High-quality bionic skin must have the following characteristics: 1) Biosafety, high biocompatibility, application to the skin is not sensitized, does not produce Inflammatory reaction; 2) Appropriate viscosity, easy to apply on the skin surface, easy to form a film; 3) Breathable and moisturizing and waterproof, blocking the harmful factors of the external environment; 4) With the biomechanical properties of normal skin, such as tensile strength and elasticity, Matches the mechanical response of the skin in daily activities; 5) Smooth and thin, good optical effect, adhered to the normal skin surface, no obvious connection interface, to achieve an aesthetic effect. However, existing artificial skin still does not fully possess the functional and physiological properties of natural skin.

 technical problem

 [0005] Type the technical problem description paragraph here.

 Problem solution

 Technical solution

 [0006] It is an object of the present invention to provide a bionic skin which is intended to solve the problem of poor safety performance of existing bionic skin.

The present invention is achieved by: a bionic skin comprising a base reactant, an adjuvant and water The emulsion polymerization occurs under the catalytic action of the catalyst to form a crosslinked network structure; wherein the basic reactant accounts for 10-20% of the total mass of the reactant, and the auxiliary agent accounts for 40-55% of the total mass of the reactant, and the rest Is water; the base reactant comprises 47-60 parts of vinyl-terminated polydimethylsiloxane, 20-29 parts of fumed silica and 17-36 parts of active hydrogen-containing polysiloxane; The catalyst is a Karstedt platinum catalyst, and the platinum content of the catalyst is 1-5%; the auxiliary agent includes a viscosity reducing agent for reducing the stickiness of the product, an emulsifier for increasing the degree of emulsification of the product, and a moisturizing agent for increasing the surface moisture of the skin. a pH adjuster for adjusting the pH of the product, a thickener for increasing the viscosity of the product, a spreading agent for improving the spreading properties of the product, and a beautifying agent for enhancing the dispersibility of the product and improving the aesthetic effect; the viscosity reducing agent comprises polydimethylsiloxane One or both of an alkane and a trisiloxane, a polydimethylsiloxane; the emulsifier comprises a polydimethylsiloxane/PEG-10/15 crosslinked polymer and a decamethylcyclopentane Silicone, diisobutyl PEG/PPG-10/7/polydimethylsiloxane One or two of the polymers; the humectant includes phenoxyethanol, a diol mixture of pentanediol and octylene glycol 1:1, one or more of propylene glycol, butylene glycol, and glycerin; The pH adjusting agent is sodium hydroxide; the thickener comprises acrylate/C10-30 alkyl acrylate crosspolymer, decamethylcyclopentasiloxane and polydimethylsiloxane polymer, poly a dimethylsiloxane crosslinked copolymer and one or more of cyclopentamethylsiloxane and sodium chloride; the spreading agent is cyclopentadimethylsiloxane; the beautifying agent is Nylon 12 modified with isopropoxytitanium triisostearate. An artificial skin is prepared from the above materials. The artificial skin skeleton is formed by the base reactant, and the properties of the artificial skin are changed by adding an adjuvant.

 [0008] The artificial skin provided by the present solution is safe and reliable, and the existing literature records indicate that the formulation components involved in the invention have safety and biocompatibility, and are not sensitized and inflammatory.

 [0009] It should be noted that the "polydimethylsiloxane and trisiloxane" mentioned in the present scheme refers to a material instead of "polydimethylsiloxane" and "trisiloxane". Alkane "two materials. Similarly, polydimethylsiloxane/PEG-1 0/15 crosslinked polymer and decamethylcyclopentasiloxane, decamethylcyclopentasiloxane and polydimethylsiloxane polymer, poly The dimethylsiloxane crosslinked copolymer and cyclopentamethylsiloxane also refer to one substance, respectively.

[0010] A further technical solution of the present invention is: the vinyl terminated polydimethylsiloxane is a mixture of Andisil VS200 product and VS 10 product; the active hydrogen group-containing polysiloxane is Andisil XL-11 product; the Karstedt platinum catalyst is a product of AB Specialty Silicones; the polydimethylsiloxane and trisiloxane are products of Dow Corning Corporation PMX-1184; the polydimethylsiloxane Dow Corning Corporation PMX-200 product; the polydimethylsiloxane/PEG-10/15 crosslinked polymer and decamethylcyclopentasiloxane are Shin-Etsu Chemical Corporation KSG-240 products; Isobutyl PEG/PPG-10/7/polydimethylsiloxane copolymer is Dow Corning Corporation FZ-2233 product; acrylate/C10-30 alkyl acrylate crosspolymer is Lubrizol

 a mixture of the company's Pemulen TR-2 product and the Ultrez 20 product; the decamethylcyclopentasiloxane and polydimethylsiloxane polymer are Dow Corning Corporation DC9045 product; the polydimethylsiloxane Alkyl Crosslinking Copolymer and Cyclopentamethylsiloxane for Dow Corning

 Corporation DC9040 product; the cyclopentasiloxane is Dow Corning

 A mixture of PMX-0245 product of Corporation and KF-995 product of Shin-Etsu Chemical Corporation; the nylon 12 modified with isopropoxysulphate is Kobo Products NylonlO-12 product.

 [0011] It should be noted that in the present scheme, the same Chinese chemical name may correspond to two different specific products. For example, the "vinyl-terminated polydimethylsiloxane plant" in this scheme uses Andisil Company respectively. Both the V S200 and VS10 products, which are vinyl-terminated polydimethylsiloxanes, have different vinyl contents and therefore have different viscosities that affect the properties of the artificial skin provided by this solution.

 Another object of the present invention is to provide a method for preparing bionic skin.

[0013] The method includes the following steps,

 [0014] Step A: preparing a first reaction liquid; the first reaction liquid comprises a homogeneously mixed base reactant, water and an auxiliary agent; wherein the basic reactant accounts for 25-36% of the total mass of the first reaction liquid, The auxiliary agent accounts for 15-25% of the total mass of the first reaction liquid, and the balance is water; the base reactant comprises 47-60 parts of vinyl-terminated polydimethylsiloxane, 20-29 parts of gas phase method Silica and 17-36 parts of active hydrogen group-containing polysiloxane;

[0015] Step B: preparing a second reaction liquid; the second reaction liquid comprises a uniformly mixed catalyst, water and a solvent; wherein the catalyst mass accounts for 0.5-3% of the total mass of the second reaction liquid, The auxiliary agent accounts for 60-80% of the total mass of the second reaction liquid, and the balance is water; the catalyst is a Karstedt platinum catalyst, and the platinum content of the catalyst is 1-5%;

 [0016] Step C: applying the first reaction solution to the skin;

[0017] Step D: applying the second reaction solution to the area of the step C in which the first reaction liquid is applied, The reaction forms artificial skin; the second reaction solution has a smear mass of 1-2 times that of the first reaction solution.

[0018] A further technical solution of the present invention is: the step A includes the following sub-steps,

[0019] Step A1: preparing a main reaction solution; the main reaction solution is obtained by uniformly mixing a base reactant, a viscosity reducer for reducing the stickiness of the product, and an emulsifier for increasing the degree of emulsification of the product; Includes 7-10 parts of Andisil's vinyl terminated polydimethylsiloxane VS

 200 products, 40-50 parts of Andisil's vinyl terminated polydimethylsiloxane VS 10 product, 20-29 parts of fumed silica and 17-36 parts of active hydrogen-containing polysiloxane;

[0020] Step A2: preparing a diluted solution: the diluted solution is obtained by uniformly mixing a thickener, a moisturizer that increases the surface moisture of the skin, and water;

[0021] Step A3: preparing a first reaction liquid; the first reaction liquid is formed by slowly adding the diluted solution to the main reaction solution until a white creamy emulsion is formed.

[0022] A further technical solution of the present invention is: The step A further comprises the substep A4: adding a pH adjuster and adjusting the first reaction solution to a pH of 5.5-6.6. In this scheme, the pH can be adjusted by a 10N sodium hydroxide solution.

[0023] A further technical solution of the present invention is: the step B includes the following sub-steps,

[0024] Step B1: preparing a thickening solution formed by uniformly mixing a thickener which increases the viscosity of the product, a spreading agent for improving the spreading property of the product, and an emulsifier which increases the degree of emulsification of the product;

[0025] Step B2: preparing a moisturizing solution composed of water and a moisturizing agent that increases the surface moisture of the skin;

 [0026] Step B3: preparing a second reaction liquid; the second reaction liquid is obtained by slowly adding the moisturizing solution to the thickening solution until a clear emulsion is formed, and then adding a catalyst.

[0027] A further technical solution of the present invention is: adding 3-7 parts of a beautifying agent for enhancing product dispersibility and improving aesthetic effect before adding the catalyst in the step B3; the beautifying agent is isopropyl triisostearate Oxygen titanium salt modified nylon.

[0028] A further technical solution of the present invention is: The viscosity reducing agent comprises 10-14 parts of Dow Coming Corporation polydimethylsiloxane and trisiloxane PMX-1184 product, Dow Coming Corporation polydimethyl Silicone PMX-200 product 1-5 parts; the emulsifier includes Shin-Etsu Chemical Corporation polydimethylsiloxane/PEG-10/15 crosslinked polymer and decamethylcyclopentasiloxane KSG - 240 products 3-7 parts, Dow Corning Corporation diisobutyl PEG/PPG-10/7/polydimethylsiloxane copolymer FZ-2233 product 0.05-0.3 parts; the thickener includes Lubrizol Corporation 0.1-0.7 parts of acrylate/C10-30 alkyl acrylate cross-linked polymer Pemulen TR-2, Lubrizol Corporation acrylate/C10-30 alkyl acrylate cross-linked polymer Ultrez 20 product 0.1-0.7 parts, The humectant comprises 0.1-0.5 parts of phenoxyethanol, 0.1-0.5 parts of a diol mixture of pentanediol and octylene glycol 1:1.

 [0029] A further technical solution of the present invention is: The thickener comprises 8-13 parts of Dow Coming Corporation's decamethylcyclopentasiloxane and polydimethylsiloxane polymer DC9045 product, Dow Corning Corporation Polydimethylsiloxane cross-linking copolymer and 1-5 parts of cyclopentamethylsiloxane DC9040 product, 0.3-0.7 parts of sodium chloride; the spreading agent includes ring-polydimethylene of Shin-Etsu Chemical Corporation 13-18 parts of the base silicone KF-995 product, 0.1-3 parts of the cyclopentadimethylsiloxane PMX-0245 product of Dow Corning Corporation; the humectant includes 0.1-0.7 parts of phenoxyethanol, 3-7 parts of a diol mixture of alcohol and octylene glycol 1:1, 8-13 parts of propylene glycol, 8-13 parts of butanediol, and 3-8 parts of glycerin; the emulsifier includes Shin-Etsu Chemical Corporation poly 2 2-7 parts of methyl silicone/PEG-10/15 crosslinked polymer and decamethylcyclopentasiloxane KSG-240, Dow Corning Corporation diisobutyl PEG/PPG-10/7/poly The dimethyl siloxane copolymer FZ-2233 product is 0.1-0.3 parts.

 Advantageous effects of the invention

 Beneficial effect

[0030] The beneficial effects of the present invention are: The first reaction liquid in the solution can be closely adhered to the skin, and after the second reaction liquid is applied, the silicone component can be crosslinked under the action of the platinum catalyst to form a strong network structure. The bionic skin cosmetics formed are washable and waterproof, and have the biomechanical properties of normal skin. The only need to directly remove the cockroaches is to remove the cockroaches, which is convenient and safe, and is quick to prepare. The program has the following advantages: 1) The existing literature records indicate that the formulation components involved in the invention have safety and biocompatibility, no sensitization and inflammation; 2) suitable viscosity, easy to spread evenly on the skin surface, easy Film formation; 3) good biomechanical properties, such as tensile modulus, adhesion, shrinkage, etc.; 4) good breathability and moisturizing properties, washable and waterproof, can block the harmful factors of the outside; 5) preparation of the patented method of the present invention The surface of the bionic skin is smooth and only 75 microns thick. The added NylonlO-12 has good optical effect, which can make the bionic skin perfectly combine with the human skin surface without obvious connecting lines. The bionic skin prepared by the method of the invention can be applied to human skin to make the skin smooth and elastic, and less Light wrinkles.

 Brief description of the drawing

 DRAWINGS

 [0031] The description paragraphs are entered here by way of a drawing.

 BEST MODE FOR CARRYING OUT THE INVENTION

 BEST MODE FOR CARRYING OUT THE INVENTION

[0032] The paragraphs describing the best mode of the invention are entered here.

Embodiments of the invention

 [0033] The following description of the various embodiments is provided by way of illustration The directional terms mentioned in the present invention, such as "upper", "lower", "before", "after", "left", "right", "inside", "outside", "side", etc., are only references Attach the direction of the drawing. Therefore, the directional terminology used is for the purpose of illustration and understanding of the invention.

[0034] The present invention firstly provides a biomimetic skin, which is formed by emulsion polymerization of a base reactant, an auxiliary agent and water under the catalytic action of a catalyst to form a crosslinked network structure; wherein the base reactant accounts for 10-20% of the total mass of the reactants, the adjuvant is 40-55% of the total mass of the reactants, the balance being water; the base reactant comprises 47-60 parts of vinyl terminated polydimethylsiloxane 20-29 parts of fumed silica and 17-36 parts of active hydrogen group-containing polysiloxane; the catalyst is a Karstedt platinum catalyst, and the catalyst has a platinum content of 1-5%; The agent includes a viscosity reducing agent for reducing the stickiness of the product, an emulsifier for increasing the degree of emulsification of the product, a moisturizing agent for increasing the surface moisture of the skin, a pH adjuster for adjusting the pH of the product, a thickener for increasing the viscosity of the product, and a spreading property for improving the product spreading property. And a beautifying agent for enhancing product dispersibility and improving aesthetic effects; the viscosity reducing agent comprising one or both of polydimethylsiloxane and trisiloxane, polydimethylsiloxane; Emulsifiers include polydimethylsiloxane/PE One or both of G-10/15 crosslinked polymer and decamethylcyclopentasiloxane, diisobutyl PEG/PPG-10/7/polydimethylsiloxane copolymer; The humectant comprises a mixture of phenoxyethanol, pentanediol and octylene glycol 1:1, a propylene glycol, a butanediol, a glycerin; the pH adjuster is sodium hydroxide; Thickeners include acrylate/C10-30 alkyl acrylate crosspolymer, decamethylcyclopentasiloxane and polydimethylsiloxane a polymer, a polydimethylsiloxane crosslinked copolymer, and one or more of cyclopentamethylsiloxane and sodium chloride; the spreading agent is cyclopentadimethylsiloxane; The beautifying agent is nylon 12 modified with isopropoxytitanium triisostearate. An artificial skin is prepared from the above materials. The artificial skin skeleton is formed by the base reactant, and the properties of the artificial skin are changed by adding an adjuvant.

 [0035] The artificial skin provided by the present solution is safe and reliable, and the existing literature records indicate that the formulation components of the present invention have safety and biocompatibility, and are not sensitized and inflammatory.

 [0036] It should be noted that the "polydimethylsiloxane and trisiloxane" mentioned in the present scheme refers to a material instead of "polydimethylsiloxane" and "trisiloxane". Alkane "two materials. Similarly, polydimethylsiloxane/PEG-1 0/15 crosslinked polymer and decamethylcyclopentasiloxane, decamethylcyclopentasiloxane and polydimethylsiloxane polymer, poly The dimethylsiloxane crosslinked copolymer and cyclopentamethylsiloxane also refer to one substance, respectively.

 [0037] Further, the vinyl terminated polydimethylsiloxane is a mixture of Andisil VS200 product and VS10 product; the active hydrogen group-containing polysiloxane is Andisil XL-11 product; The Karst edt platinum catalyst is a product of AB Specialty Silicones; the polydimethylsiloxane and trisiloxane are products of Dow Corning Corporation PMX-1184; the polydimethylsiloxane is Dow Coming Corporation PMX-200 product; the polydimethylsiloxane/PEG-10/15 crosslinked polymer and decamethylcyclopentasiloxane are products of Shin-Etsu Chemical Corporation KSG-240; PEG/PPG-10/7/polydimethylsiloxane copolymer for Dow Corning

 Corporation FZ-2233 product; acrylate/C 10-30 alkyl acrylate crosspolymer is a mixture of Lubri zol Corporation Pemulen TR-2 product and Ultrez 20 product; the decamethylcyclopentasiloxane and The polydimethylsiloxane polymer is a Dow Corning Corporation DC9045 product; the polydimethylsiloxane crosslinked copolymer and cyclopentamethylsiloxane are Dow Corning

 Corporation DC9040 product; the cyclopentasiloxane is Dow Corning

 A mixture of PMX-0245 product of Corporation and KF-995 product of Shin-Etsu Chemical Corporation; the nylon 12 modified with isopropoxysulphate is Kobo Products NylonlO-12 product.

 [0038] The present invention also discloses a method of producing bionic skin.

 [0039] The method includes the following steps,

[0040] Step A: preparing a first reaction liquid; the first reaction liquid includes a homogeneously mixed base reactant, water And an auxiliary agent; wherein the basic reactant accounts for 25-36% of the total mass of the first reaction liquid, the auxiliary agent accounts for 15-25% of the total mass of the first reaction liquid, and the rest is water; the basic reactant includes 47-60 parts of vinyl-terminated polydimethylsiloxane, 20-29 parts of fumed silica, and 17-36 parts of active hydrogen-containing polysiloxane; [0041] Step A includes the following Step by step,

 [0042] Step A1: preparing a main reaction solution; the main reaction solution is obtained by uniformly mixing a base reactant, a viscosity reducer for reducing the stickiness of the product, and an emulsifier for increasing the degree of emulsification of the product; Includes 7-10 parts of Andisil's vinyl terminated polydimethylsiloxane VS

 200 products, 40-50 parts of Andisil's vinyl terminated polydimethylsiloxane VS 10 product, 20-29 parts of fumed silica and 17-36 parts of active hydrogen-containing polysiloxane;

[0043] Step A2: preparing a diluted solution: the diluted solution is obtained by uniformly mixing a thickener, a moisturizer that increases the surface moisture of the skin, and water;

[0044] Step A3: preparing a first reaction liquid; the first reaction liquid is formed by slowly adding the diluted solution to the main reaction solution until a white creamy emulsion is formed.

Step A4: A pH adjuster is added and the first reaction solution is adjusted to a pH of 5.5-6.6. In this scheme, the pH can be adjusted by a 10N sodium hydroxide solution.

[0046] wherein the viscosity reducing agent comprises Dow Corning Corporation polydimethylsiloxane and trisiloxane PMX-1184 product 10-14 parts, Dow Coming

 Corporation Corporation Polydimethylsiloxane PMX-200 product 1-5 parts; the emulsifier includes Shin-Etsu Chemical Corporation polydimethylsiloxane / PEG-10 / 15 cross-linked polymer and decamethyl 3-7 parts of cyclopentasiloxane KSG-240 product, Dow Corning Corporation diisobutyl PEG/PPG-10/7/polydimethylsiloxane copolymer FZ-2233 product 0.05-0.3 parts; Thickeners include Lubrizol Corporation acrylate/C10-30 alkyl acrylate crosspolymer PEmulen

0.1-0.7 parts of TR-2 product, 0.1-0.7 parts of Lubrizol Corporation acrylate/C10-30 alkyl acrylate cross-linked polymer Ultre _Z 20 product, the humectant includes phenoxyethanol 0.1-0.5 parts, pentylene 0.1-0.5 parts of a mixture of alcohol and octylene glycol 1:1

[0047] Step B: preparing a second reaction liquid; the second reaction liquid comprises a uniformly mixed catalyst, water and a solvent; wherein the catalyst mass accounts for 0.5-3% of the total mass of the second reaction liquid, The auxiliary agent accounts for 60-80% of the total mass of the second reaction liquid, and the balance is water; the catalyst is a Karstedt platinum catalyst, the catalyst The platinum content is 1-5%;

[0048] The step B includes the following sub-steps,

 [0049] Step B1: preparing a thickening solution formed by uniformly mixing a thickener which increases the viscosity of the product, a spreading agent for improving the spreading property of the product, and an emulsifier which increases the degree of emulsification of the product;

 [0050] Step B2: preparing a moisturizing solution composed of water and a moisturizing agent that increases the surface moisture of the skin;

 [0051] Step B3: preparing a second reaction liquid; the second reaction liquid is obtained by slowly adding the moisturizing solution to the thickening solution until a clear emulsion is formed, and then adding a catalyst.

 [0052] 3-7 parts of a beautifying agent for enhancing product dispersibility and improving aesthetic effect are added before the catalyst is added in the step B3; the beautifying agent is nylon modified with isopropoxytitanate.

 [0053] The thickener includes 8-13 parts of Dow Corning Corporation's decamethylcyclopentasiloxane and polydimethylsiloxane polymer DC9045 product, Dow Corning Corporation polydimethylsiloxane 1-3 parts of a copolymer and a cyclopentamethylsiloxane DC9040 product, and 0.3-0.7 parts of sodium chloride; the spreading agent includes a cyclopentadimethylsiloxane KF-995 product of Shin-Etsu Chemical Corporation 13- 18 parts, Dow Corning Corporation, 5-penta-dimethylsiloxane PMX-0245 product 0.1-3 parts; the humectant includes phenoxyethanol 0.1-0.7 parts, pentanediol and octylene glycol 1: 1 3-7 parts of the diol mixture, 8-13 parts of propylene glycol, 8-13 parts of butanediol, and 3-8 parts of glycerin; the emulsifier includes Shin-Etsu Chemical Corporation polydimethylsiloxane/PEG- 2/7 parts of 10/15 crosslinked polymer and decamethylcyclopentasiloxane KSG-240, Dow Corning Corporation diisobutyl PEG/PPG-10/7/polydimethylsiloxane copolymer FZ-2233 product 0.1-0.3 parts.

 [0054] Step C: applying the first reaction solution to the skin;

 [0055] Step D: applying the second reaction solution to the area where the first reaction liquid is applied in the step C, and reacting to form artificial skin; the application quality of the second reaction liquid is the first reaction 1-2 times the liquid.

Specific examples of preparing artificial skin according to the above method are given below.

DETAILED DESCRIPTION OF THE INVENTION 1:

[0058] 1. Emulsion 1

[0059] a in the mixer 1, 31.0% of the base reactant, 12.0 <3⁄4PMX-1184 (polydimethylsiloxane and trisiloxane), 2.0% PMX-200 (polydimethylsiloxane), 5.0% KSG-240 (polydimethylsiloxane/PEG-10/15 crosslinked polymer and decamethylcyclopentasiloxane), 0.1<3⁄4FZ -2233 (diisobutyl PEG/PPG-10/7/polydimethylsiloxane copolymer) Mix well.

 [0060] wherein 25% of the base reactant is fumed silica, and the fumed silica enhances the mechanical toughness and viscosity of the product. The remaining 75% by mass contained 11.0% vinyl terminated polydimethylsiloxane (Andisil, VS 200), 60.0% vinyl terminated polydimethylsiloxane (Andisil, VS10) and 29.0% active Hydrogen-based polysiloxane (Andisil, XL-11).

[0061] b. In the mixer 2, 48.4% water, 0.4 <¾Pemulen TR-2 (acrylates / C10-30 alkyl acrylate cross-linked polymer), 0.4 <¾Ult _rez 20 (acrylates / C10- 30 alkyl acrylate crosslinked polymer), 0.2% phenoxyethanol, 0.3% diol mixture (pentanediol and octylene glycol, 1:1) were uniformly mixed.

 c. The mixture obtained in step b was slowly added to the mixture obtained in the step a until a white creamy emulsion was formed, and 0.2% 10N sodium hydroxide solution was added thereto, and the pH was adjusted to 5.5 to 6.5.

 2. Emulsion 2

 [0064] d. In Mixer 3, 10.0% DC9045 (decamethylcyclopentasiloxane and polydimethylsiloxane polymer), 2.0%

 DC9040 (polydimethylsiloxane cross-linked copolymer and cyclopentamethylsiloxane), 5.0<3⁄4KSG-240 (polydimethylsiloxane/PEG-10/15 cross-linked polymer and decamethyl Cyclopentasiloxane), 0.2% FZ-2233 (diisobutyl PEG/PPG-10/7/polydimethylsiloxane copolymer), 15.0% KF-995 (cyclopentadimethylsiloxane) Alkane), 1.0% PMX-0245 (cyclopentadimethylsiloxane), 0.5% sodium chloride, 5.0% glycerol mixed evenly

[0065] e in the mixer 4, 30.0% water, 0.3% phenoxyethanol, 5.0% diol mixture (pentylene glycol and octylene glycol, 1:1), 10.0% propylene glycol, 10.0% butanediol well mixed.

[0066] f The mixture obtained in step e is slowly dropped into the mixture obtained in step d until a clear emulsion is formed, then 5.0 < 3⁄4 NylonlO-12 is slowly added to the emulsion to be homogeneously mixed, and finally 1.0% Karstedt platinum catalyst solution is added (including 2.0% platinum) and mix well.

[0067] The ratio of the emulsion 1 and the emulsion 2 is 2:3, the emulsion 1 is applied first, and then the emulsion 2 is applied. The emulsion 1 can be closely adhered to the skin, and the silicone component is coated with the platinum catalyst after the emulsion 2 is applied. Under the action, it can be cross-linked to form a firm network structure, and the formed bionic skin cosmetics are washable and waterproof, and have the biomechanical properties of normal skin. To remove the crucible, just tear it.

 [0068] After testing, the mechanical properties of the artificial skin obtained in the specific example are as follows.

The tensile modulus was 0.45 MPa, the strain at break was 800%, and the adhesion strength was 78 N mm ^-1 .

 [0070] The tensile test showed that the tensile modulus of normal skin at 40% strain was 0.5-1.95 MPa, and the bionic skin cosmetic prepared by the method of the present invention had a tensile modulus of 0.5 MPa and a strain at break of 240%. Therefore, the artificial skin provided by this program has good elasticity.

[0071] After applying the bionic skin cosmetic prepared by the patented method of the present invention to the forearm for 24 hours, the skin retraction intercondylar phase was reduced by 26.7% compared with before application (750 ms, 550 ms before and after application). This indicates a significant improvement in skin elasticity.

 [0072] The transepidermal water loss (TEWL) test showed that the TEWL of the bionic skin cosmetic prepared by the method of the present invention decreased by 20% after 24 hours of application (4.0 g/m 3⁄4, 3.2 g/m 3⁄4 before and after application for 24 hours). )

. Explain that the artificial skin provided by this program can effectively maintain skin moisture and avoid water loss.

[0073] In summary, the artificial skin provided by the present solution has the following advantages: 1) The existing literature records indicate that the formulation components of the present invention have safety and biocompatibility, and are not sensitized and inflammatory; 2 Appropriate viscosity, easy to spread on the skin surface, easy to form a film; 3) good biomechanical properties, such as tensile modulus, adhesion, shrinkage, etc.; 4) good breathability and moisturizing properties, washable and waterproof, can block the outside world Invasion of harmful factors; 5) The bionic skin prepared by the patented method of the invention has a smooth surface and a thickness of only 75 μm, and the added Nylonl O-12 has a good optical effect, so that the bionic skin can be perfectly combined with the surface of the human skin without obvious connection. Boundary. The bionic skin prepared by the method of the invention can be applied to human skin to make the skin smooth, elastic and wrinkle-reducing.

 The above is only the preferred embodiment of the present invention, and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the present invention. Within the scope of protection of the invention.

 Industrial applicability

[0075] Enter the paragraph of industrial applicability description here.

 Sequence table free content

[0076] Type the sequence table free content description paragraph here.

Claims

Claim [Claim 1] A bionic skin, characterized in that: the bionic skin is formed by emulsion polymerization of a base reactant, an auxiliary agent and water under the catalysis of a catalyst to form a crosslinked network structure; wherein the base reactant 10-20% of the total mass of the reactants, the auxiliary agent accounts for 40-55% of the total mass of the reactants, and the balance is water; the base reactant comprises 47-60 parts of vinyl-terminated polydimethylsiloxane Alkane, 20-29 parts of fumed silica and 17-36 parts of active hydrogen group-containing polysiloxane; the catalyst is a Karstedt platinum catalyst, and the catalyst has a platinum content of 1-5%; Auxiliaries include viscosity reducers that reduce the stickiness of the product, emulsions that increase the degree of emulsification of the product, moisturizers that increase the moisture level of the skin, _P H conditioners that adjust the pH of the product, thickeners that increase the viscosity of the product, and improved product spreads. a performance spreading agent and a beautifying agent for enhancing product dispersibility and improving aesthetic effects; the viscosity reducing agent comprises one or both of polydimethylsiloxane and trisiloxane, polydimethylsiloxane The emulsifier includes polydimethyl Oxygen/PEG-10/15 crosslinked polymer and one or both of decamethylcyclopentasiloxane, diisobutyl PEG/PPG-10/7/polydimethylsiloxane copolymer The humectant includes phenoxyethanol, a diol mixture of pentanediol and octylene glycol 1: 1, one or more of propylene glycol, butanediol, and glycerin; and the _P H regulator is sodium hydroxide The thickener includes an acrylate/C10-30 alkyl acrylate crosspolymer, decamethylcyclopentasiloxane and a polydimethylsiloxane polymer, and a polydimethylsiloxane crosslink. a copolymer and one or more of cyclopentamethylsiloxane and sodium chloride; the spreading agent is cyclopentadimethylsiloxane; and the beautifying agent is triisostearate isopropoxy Titanium salt modified nylon 12. [Claim 2] The bionic skin according to claim 1, wherein the vinyl-terminated polydimethylsiloxane is a mixture of an Andisil VS200 product and a VS10 product; the active hydrogen-containing group The polysiloxane is the Andisil XL-11 product; the Karstedt platinum catalyst is a product of AB Specialty Silicones; the polydimethylsiloxane and trisiloxane are Dow Corning Corporation PMX-1184; Polydimethylsiloxane is Dow Corning Corporation PMX-200 product; the polydimethylsiloxane/PEG-10/15 crosslinked polymer and decamethylcyclopentasiloxane are Shin-Etsu Chemical Corporation KSG-240 product; the diisobutyl PEG/PPG-10/7/polydimethylsiloxane copolymer is Dow Corning  Corporation FZ-2233 product; acrylate/C10-30 alkyl acrylate crosspolymer is a mixture of Lubrizol Corporation Pemulen TR-2 product and Ultrez 20 product; the decamethylcyclopentasiloxane and poly 2 The methyl siloxane polymer is Dow Corning Corporation DC9045 product; the polydimethylsiloxane crosslinked copolymer and cyclopentamethyl siloxane are Dow Corning Corporation DC9040 product; The methyl siloxane is a mixture of Dow Corning Corporation PMX-0245 product and Shin-Etsu Chemical Corporation KF-995 product; the triisostearate isopropoxide modified nylon 12 is Kobo Products NylonlO- 12 production p [Claim 3] A method for preparing a bionic skin, comprising the following steps,  Step Α: preparing a first reaction liquid; the first reaction liquid comprises a homogeneously mixed base reactant, water and an auxiliary agent; wherein the basic reactant accounts for 25-3 6% of the total mass of the first reaction liquid, The auxiliary agent accounts for 15-25% of the total mass of the first reaction liquid, and the balance is water; the base reactant comprises 47-60 parts of vinyl-terminated polydimethylsiloxane and 20-29 parts of fumed white carbon Black and 17-36 parts of active hydrogen group-containing polysiloxane;  Step Β: preparing a second reaction liquid; the second reaction liquid comprises a uniformly mixed catalyst, water and an auxiliary agent; wherein the catalyst mass accounts for 0.5-3% of the total mass of the second reaction liquid, the auxiliary agent Accounting for 60-80% of the total mass of the second reaction liquid, the balance being water; the catalyst Qi 1J is a Karstedt platinum catalyst, and the platinum content of the catalyst is 1-5%  Step C: applying the first reaction solution to the skin;  Step D: applying the second reaction solution to the area where the first reaction liquid is applied in the step C, and reacting to form artificial skin; the application quality of the second reaction liquid is 1 of the first reaction liquid -2 times.  [Claim 4] The method for preparing bionic skin according to claim 3, wherein: the step  A includes the following substeps, Step A1: preparing a main reaction solution; the main reaction solution is reduced by a base reactant The viscosity-reducing agent of the product is obtained by uniformly mixing the emulsifier which increases the degree of emulsification of the product; the base reactant comprises 7-10 parts of the vinyl-terminated polydimethylsiloxane VS 200 product of Andisil Company, 40-50 parts of Andisil's vinyl terminated polydimethylsiloxane VS 10 product, 20-29 parts of fumed silica and 17-36 parts of active hydrogen group-containing polysiloxane;  Step A2: preparing a diluted solution: the diluted solution is obtained by uniformly mixing a thickener, a moisturizer for increasing the surface moisture of the skin, and water;  Step A3: preparing a first reaction liquid; the first reaction liquid is formed by slowly adding the diluted solution to the main reaction solution until a white creamy emulsion is formed. [Claim 5] The method for preparing bionic skin according to claim 4, wherein: the step  A also includes substep A4: adding a pH adjuster and adjusting the first reaction solution to a pH of 5. 5-6.6.  [Claim 6] The method for preparing bionic skin according to any one of claims 3-5, wherein: the step B comprises the following sub-steps,  Step B1: preparing a thickening solution which is formed by uniformly adding a thickener which increases the viscosity of the product, a spreading agent which improves the spreading property of the product, and an emulsifier which increases the degree of emulsification of the product;  Step B2: preparing a moisturizing solution consisting of water and a moisturizer for increasing the surface moisture of the skin;  Step B3: preparing a second reaction liquid; the second reaction liquid is obtained by slowly adding the moisturizing solution to the thickening solution until a clear emulsion is formed, and then adding a catalyst.  [Claim 7] The method for preparing bionic skin according to claim 6, wherein: the step  Before adding the catalyst to B3, 3-7 parts of a beautifying agent for enhancing product dispersibility and improving aesthetic effect are added; the beautifying agent is nylon modified with isopropoxytitanate.  [Claim 8] The method for preparing bionic skin according to claim 4, wherein: the viscosity reduction includes Dow Corning Corporation's polydimethylsiloxane and trisiloxane PMX-1184 products 10-14 parts, Dow Corning Corporation polydimethylsiloxane PMX-200 products 1-5 parts; Emulsifiers include Shin-Etsu Chemical  Corporation Polydimethylsiloxane/PEG-10/15 Crosslinked Polymer and Decamethylcyclopentasiloxane KSG-240 3-7 copies, Dow Corning  Corporation diisobutyl PEG/PPG-10/7/polydimethylsiloxane copolymer FZ-22 33 product 0.05-0.3 parts; the thickener includes Lubrizol  Corporation Acrylate / C 10-30 Alkyl Acrylate Crosslinked Polymer Pemulen TR-2 Product 0.1-0.7 parts, Lubrizol Corporation Acrylate / C10-30 Alkyl Acrylate Crosslinked Polymer Ultrez  20 products 0.1-0.7 parts, the humectant comprising 0.1-0.5 parts of phenoxyethanol, 0.1-0.5 parts of a diol mixture of pentanediol and octylene glycol 1:1. [Claim 9] The method for producing bionic skin according to claim 6, wherein the thickener comprises Dow Corning Corporation, decamethylcyclopentasiloxane and polydimethylsiloxane polymer 8 to 13 parts of DC9045, 1-3 parts of Dow Corning Corporation polydimethylsiloxane crosslinked copolymer and cyclopentamethylsiloxane DC9040, and 0.3 to 0.7 parts of sodium chloride; the spreading agent includes 13-18 parts of cyclopentapolydimethylsiloxane KF-995 product of Shin-Etsu Chemical Corporation, 0.1-3 parts of Dow Corning Corporation cyclopentadimethylsiloxane PMX-0245 product; the humectant Including phenoxyethanol 0.1-0. 7 parts, pentanediol and octylene glycol 1:1 mixture of diol 3-7 parts, propylene glycol 8-13 parts, butanediol 8-13 parts, glycerol 3-8 parts; The emulsifier includes Shin-Etsu Chemical  Corporation Polydimethylsiloxane/PEG-10/15 Crosslinked Polymer and Decamethylcyclopentasiloxane KSG-240 2-7, Dow Corning  Corporation diisobutyl PEG/PPG-10/7/polydimethylsiloxane copolymer FZ-22 33 product 0.1-0.3 parts.