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WO2018105480A1 - Outil à fines saillies destine à être utilisé pour la stimulation de la peau, et son procédé de fabrication - Google Patents

Outil à fines saillies destine à être utilisé pour la stimulation de la peau, et son procédé de fabrication Download PDF

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Publication number
WO2018105480A1
WO2018105480A1 PCT/JP2017/043041 JP2017043041W WO2018105480A1 WO 2018105480 A1 WO2018105480 A1 WO 2018105480A1 JP 2017043041 W JP2017043041 W JP 2017043041W WO 2018105480 A1 WO2018105480 A1 WO 2018105480A1
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WO
WIPO (PCT)
Prior art keywords
fine
protrusion
tool
skin irritation
less
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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PCT/JP2017/043041
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English (en)
Japanese (ja)
Inventor
和樹 磯
貴利 新津
智志 上野
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Kao Corp
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Kao Corp
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Filing date
Publication date
Application filed by Kao Corp filed Critical Kao Corp
Publication of WO2018105480A1 publication Critical patent/WO2018105480A1/fr
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Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
    • A61H39/04—Devices for pressing such points, e.g. Shiatsu or Acupressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
    • A61H39/08—Devices for applying needles to such points, i.e. for acupuncture ; Acupuncture needles or accessories therefor

Definitions

  • the present invention relates to a fine protrusion for skin irritation and a method for producing the same.
  • Patent Document 1 describes a fine needle that gives a stimulus to the skin without the tip piercing the skin.
  • the fine needle described in Patent Document 1 is adhered to a pressure sensitive adhesive sheet piece such as a bandage, and the pressure sensitive adhesive sheet piece having the fine needle adhered thereto is adhered to the skin, thereby bringing the fine needle into contact with or pressing the skin. Used as such.
  • Patent Document 1 if such a fine needle is used to stimulate the skin, numbness in the soles, upper and lower limbs, finger joint pain, swelling, fifty shoulders, headache, low back pain, knee pain, elbow pain, muscle pain, It is described that it is effective in relieving stiff shoulders.
  • the present invention is a skin irritation microprojection device having a fine hollow projection with a hollow inside on a base.
  • the tip of the microhollow projection is curved outwardly or flat. It has become.
  • a method for producing a skin irritation fine projection tool comprises contacting a convex part provided with a heating means from one side of a base sheet formed with a thermoplastic resin so that the corresponding contact part in the base sheet is
  • a protrusion forming step of forming a protrusion protruding from the other surface side of the base sheet by piercing the base sheet into the base sheet while being softened by heat, and the convex mold inside the protrusion A cooling step of cooling the convex portion in a state where the portion is stabbed, and a release step of forming the fine protrusion for skin stimulation by removing the convex portion from the inside of the protruding portion after the cooling step.
  • the convex part used in the protruding part forming step includes a top part having an angle of more than 60 degrees and 180 degrees or less at a tip part in a longitudinal sectional view along the thickness direction.
  • FIG. 1 is a schematic perspective view of a skin irritation microprojection tool according to a first preferred embodiment of the present invention in which a plurality of microhollow projections are arranged on a base.
  • FIG. 2 is a perspective view of the fine tool for skin stimulation focusing on one fine hollow protrusion shown in FIG. 3 is a cross-sectional view taken along line III-III shown in FIG.
  • FIG. 4 is an explanatory view showing a method for measuring the width of the tip of the fine projection tool.
  • FIG. 5 is a schematic perspective view of a fine projection tool for skin irritation according to a preferred embodiment of the present invention further having an adhesive sheet.
  • FIG. 6 is a usage diagram illustrating a usage state of the skin irritation fine projection tool shown in FIG. 5.
  • FIG. 7 is a diagram showing an overall configuration of a manufacturing apparatus according to the first embodiment for manufacturing the skin irritation fine projection shown in FIG. 1.
  • FIG. 8 is a cross-sectional view of the convex portion of the manufacturing apparatus shown in FIG. 7 as viewed longitudinally along the thickness direction.
  • 9 (a) to 9 (e) are diagrams illustrating a process of manufacturing a skin irritation fine projection using the manufacturing apparatus shown in FIG.
  • FIG. 10 is a vertical cross-sectional view of a skin irritation microprojection tool according to a second preferred embodiment of the present invention (corresponding to FIG. 3).
  • 11 (a) to 11 (e) are diagrams for explaining a process of manufacturing a fine protrusion for skin stimulation using the manufacturing apparatus of the second embodiment (corresponding to FIG. 9).
  • FIG. 12 is a cross-sectional view of the convex portion of the manufacturing apparatus shown in FIG. 11 as viewed longitudinally along the thickness direction (corresponding to FIG. 8).
  • the fine needle described in Patent Document 1 has a solid structure in which the convex portion is integrally formed with the substrate, a functional material such as a magnetic material or a heat generating material can be disposed inside the convex portion. difficult. Moreover, since the fine needle described in Patent Document 1 has a solid structure, the material cost increases.
  • an object of the present invention is to provide a fine protrusion, a patch having the same, and a method for manufacturing the same, which can eliminate the disadvantages of the above-described conventional technology.
  • FIG. 1 is a perspective view of a skin irritation microprojection tool 1 (hereinafter also referred to as a microprojection tool 1) according to the first embodiment.
  • the fine projection tool 1 according to the first embodiment has a first direction X and a second direction Y orthogonal thereto, and includes a plurality of fine hollow projections 3 on a sheet-like base 2.
  • the number of the fine hollow protrusions 3, the arrangement of the fine hollow protrusions 3, and the shape of the fine hollow protrusions 3 are not particularly limited, but the fine protrusion tool 1 of the first embodiment has 9 on the upper surface of the sheet-like base 2.
  • a plurality of truncated cone-shaped hollow projections 3 are arranged.
  • the nine fine hollow projections 3 arranged are arranged in three rows in the second direction Y direction and in three columns in the first direction X direction.
  • the direction in which a later-described base sheet 2A is conveyed corresponds to the second direction Y
  • the direction orthogonal to the direction to convey corresponds to the first direction X.
  • FIG. 2 is a perspective view of the fine protrusion 1 focusing on one fine hollow protrusion 3 among the plurality of arranged fine hollow protrusions 3 of the fine protrusion 1.
  • FIG. 3 is a cross-sectional view of the fine projection 1 as viewed in a longitudinal section along the thickness direction (Z direction) at the center position CP of the tip 3U of the fine projection 1.
  • the fine projection tool 1 for skin stimulation according to the first embodiment is different from the one for the purpose of penetrating the skin like an injection needle, and stimulates the projection by pressing the skin or the skin.
  • the term “for skin irritation” can also be called non-invasive.
  • the fine hollow protrusion 3 has a hollow interior as viewed in a longitudinal section. Specifically, a hollow space is formed extending through the base 2 and into the inside of the fine hollow protrusion 3. In the fine projection tool 1, the space inside the fine hollow projection 3 is formed in a truncated cone shape.
  • the tip of the tip portion 3U of the fine hollow projection 3 is curved outwardly and convexly.
  • the tip of the fine hollow protrusion 3 of the fine projection tool 1 is curved outwardly and the fine hollow protrusion 3 has a truncated cone shape.
  • the microprojection tool 1 of the first embodiment has a top portion 3t that is gently curved convexly in the thickness direction (Z direction) at the center position CP of the tip 3U of the microhollow projection 3.
  • the fine hollow projection 3 of the fine projection tool 1 has a truncated cone shape having a curved top portion 3t, but the fine hollow projection 3 may have a truncated cone shape with a flat tip. Alternatively, the tip may have a flat columnar shape or the like. Further, the surface of the fine hollow protrusion 3 does not communicate with the internal space, and the surface of the fine hollow protrusion forms a continuous surface.
  • the width W of the tip of the microhollow projection 3 is preferably 0.5 mm or more, and more preferably 0.6 mm or more. And it is preferably 5 mm or less, more preferably 1 mm or less, specifically preferably 0.5 mm or more and 5 mm or less, more preferably 0.6 mm or more and 1 mm.
  • the fineness of the fine hollow protrusion 3 means that the width W of the tip is preferably 5 mm or less, more preferably 1 mm or less.
  • the width W of the tip of the fine hollow protrusion 3 is measured as follows.
  • a cross section of the tip 3U of the fine hollow projection 3 is observed as a SEM image shown in FIG. 4 in a state where the cross section is enlarged by a predetermined magnification using a scanning electron microscope (SEM) or a microscope.
  • SEM scanning electron microscope
  • the imaginary straight line ILa is extended along the straight line portion on one side 3a of the both sides 3a and 3b
  • the imaginary straight line ILb is extended along the straight line portion on the other side 3b.
  • a location where the one side 3a is separated from the virtual straight line ILa is obtained as the first distal point 3a1
  • a location where the other side 3b is separated from the virtual straight line ILb is obtained as the second distal point 3b1.
  • the length of the straight line connecting the first tip point 3a1 and the second tip point 3b1 thus determined is measured using a scanning electron microscope (SEM) or a microscope, and the measured length of the straight line is calculated.
  • the width W of the tip of the fine hollow projection 3 is assumed to be.
  • both sides 3a and 3b which are the side surfaces of the fine hollow protrusions rising from the base, are not straight lines, from the intersection of the horizontal line on the upper surface of the base 2 and the vertical line passing through the center of the fine hollow protrusion 3,
  • the intersection between each virtual straight line extending 45 ° to the left and right and the curve of the surface of the fine hollow projection is defined as two virtual left and right points, and the distance between the two virtual left and right virtual points is defined as the width W of the tip of the fine hollow projection 3.
  • the fine hollow protrusion 3 is a longitudinal cross-sectional view and stimulates the skin when the width of the tip of the fine hollow protrusion 3 is W and the radius of curvature of each of the corner portions 3E and 3E is R.
  • the ratio W / R of the width W of the tip to the radius of curvature R is preferably 0.1 or more, more preferably 1 or more, and preferably 10 or less from the viewpoint of being used for the purpose of making it difficult to pierce the skin. Yes, more preferably 5 or less, specifically preferably 0.1 or more and 10 or less, more preferably 1 or more and 5 or less.
  • the radius of curvature R is preferably 0.05 mm or more, more preferably 0.1 mm or more, and preferably 50 mm or less, more preferably 2 mm or less.
  • the thickness is preferably 0.05 mm or more and 50 mm or less, and more preferably 0.1 mm or more and 2 mm or less.
  • the radius of curvature R of both corners 3E, 3E of the fine projection tool 1 is measured as follows.
  • a cross section of the tip 3U of the fine hollow projection 3 is observed as a SEM image shown in FIG. 4 in a state where the cross section is enlarged by a predetermined magnification using a scanning electron microscope (SEM) or a microscope.
  • SEM scanning electron microscope
  • the imaginary straight line ILa is extended along the straight line portion on one side 3a of the both sides 3a and 3b
  • the imaginary straight line ILb is extended along the straight line portion on the other side 3b.
  • a location where the one side 3a is separated from the virtual straight line ILa is obtained as the first distal point 3a1
  • a location where the other side 3b is separated from the virtual straight line ILb is obtained as the second distal point 3b1.
  • the radius of curvature is R.
  • the contour radius between the second tip point 3b1 and the center position CP is set to the curvature radius R of the corner 3E.
  • both sides 3a and 3b which are the side surfaces of the fine hollow protrusions rising from the base, are not straight lines, from the intersection of the horizontal line on the upper surface of the base 2 and the vertical line passing through the center of the fine hollow protrusion 3,
  • the intersection of each virtual straight line extending 45 degrees to the left and right and the curve of the surface of the fine hollow projection is defined as two left and right virtual points, and these two left and right virtual points are respectively read as a first tip point 3a1 and a second tip point 3b1.
  • the fine hollow protrusion 3 is used for stimulating the skin and has a protrusion height H1 (see FIG. 3) of preferably 0.01 mm or more, more preferably 0.02 mm or more, from the viewpoint of making it difficult to pierce the skin. Yes, and preferably 10 mm or less, more preferably 5 mm or less, specifically preferably 0.01 mm or more and 10 mm or less, and more preferably 0.02 mm or more and 5 mm or less.
  • the fine hollow protrusion 3 has an average thickness T1 of preferably 0.005 mm or more, more preferably 0.01 mm or more, and preferably 1.0 mm or less, more preferably 0.5 mm or less, Specifically, it is preferably 0.005 mm or more and 1.0 mm or less, and more preferably 0.01 mm or more and 0.5 mm or less.
  • the base 2 has a thickness T2 of preferably 0.01 mm or more, more preferably 0.02 mm or more, and preferably 1.0 mm or less, more preferably 0.7 mm or less. Is preferably 0.01 mm or more and 1.0 mm or less, and more preferably 0.02 mm or more and 0.7 mm or less.
  • the average thickness T1 of the fine hollow protrusions 3 is a thickness measured in the horizontal direction at a position that is half the height of the fine hollow protrusions 3 (that is, a position that has a height of H1 / 2).
  • the cross-sectional width of the fine hollow protrusion 3 in the horizontal direction at a position half the height of the fine hollow protrusion 3 (H1 / 2 height position) is preferably 0.5 mm or more, more preferably 0.6 mm or more. And, it is preferably 7 mm or less, more preferably 4 mm or less, specifically preferably 0.5 mm or more and 7 mm or less, more preferably 0.6 mm or more and 4 mm or less.
  • the nine fine hollow projections 3 of the same shape and size arranged on the upper surface of the sheet-like base 2 have a uniform center-to-center distance in the second direction Y and a uniform center-to-center distance in the first direction X.
  • the center distance in the second direction Y and the center distance in the first direction X are preferably the same distance.
  • the distance between the centers of the fine hollow protrusions 3 in the second direction Y is preferably 0.01 mm or more, more preferably 0.05 mm or more, and preferably 10 mm or less, more preferably 5 mm or less. Specifically, it is preferably 0.01 mm or more and 10 mm or less, and more preferably 0.05 mm or more and 5 mm or less.
  • the distance between the centers of the fine hollow protrusions 3 in the first direction X is preferably 0.01 mm or more, more preferably 0.05 mm or more, and preferably 10 mm or less, more preferably 5 mm or less. Specifically, it is preferably 0.01 mm or more and 10 mm or less, and more preferably 0.05 mm or more and 5 mm or less.
  • the fine hollow protrusions 3 arranged on the upper surface of the sheet-like base 2 are preferably 1 or more, more preferably 9 or more, preferably 400 or less, more preferably 100 per 1 cm 2. Specifically, it is preferably 1 or more and 400 or less, more preferably 9 or more and 100 or less per 1 cm 2 .
  • the microprojection tool 1 of the first embodiment may be in a form having an adhesive means so that the surface on which the microhollow projections 3 are arranged is fixed to the skin.
  • It can be used in the form of a patch 10P having a sheet 4.
  • the pressure-sensitive adhesive sheet 4 has a pressure-sensitive adhesive base sheet 4s wider than the area of the sheet-like base 2 and a pressure-sensitive adhesive 4a coated on the entire surface of the pressure-sensitive adhesive base sheet 4s.
  • the adhesive base sheet 4s a nonwoven fabric, a film or the like generally used in a technical field such as a bandage can be used.
  • the adhesive 4a the adhesive agent etc. which are generally used in technical fields, such as a bandage, can be used.
  • the microprojection tool 1 in the form of a patch 10P adheres to a part of the body where the skin is to be stimulated for the purpose of alleviating physical fatigue such as numbness of the limbs, back pain, muscle pain, and stiff shoulders. It is used by being fixed via the agent 4a. By fixing the patch 10P in this way, the fine hollow protrusion 3 of the fine protrusion 1 is pressed against the skin.
  • the fine projection tool 1 of the first embodiment has the following advantages because the inside of the fine hollow projection 3 is hollow.
  • the fine projection tool 1 of 1st Embodiment has the hollow which forms an air layer in the inside of the fine hollow protrusion 3, it produces a heat insulation effect and it is hard to feel a cool feeling compared with a metal needle.
  • the width W of the tip of the fine hollow projection 3 is larger than 0.5 mm, and the tip of the tip portion 1U is curved outwardly so that the skin It is hard to be stabbed in, and it is hard to produce discomfort.
  • the microprojection tool 1 according to the first embodiment may not be used in the form of the patch 10P as shown in FIG. 6.
  • the microprojection tool 1 adheres to the base 2 around the micro hollow projection 3 of the microprojection tool 1. You may use it with the form which distributes the agent 4a.
  • FIG. 7 shows the overall configuration of the manufacturing apparatus 100 according to the first embodiment used for carrying out the manufacturing method according to the first embodiment.
  • the fine hollow protrusion 3 of the fine protrusion 1 is very small, but for convenience of explanation, the fine hollow protrusion 3 of the fine protrusion 1 is drawn very large in FIG. .
  • the manufacturing apparatus 100 includes, from the upstream side toward the downstream side, a protrusion part forming part 10 that forms the protrusion part 3A on the base sheet 2A, a cooling part 20, and a convex part 11 described later.
  • a release part 30 for extracting the fine protrusions 1
  • a cutting part 40 for cutting the fine protrusions 1
  • a re-pitch part 50 for adjusting the interval between the fine protrusions 1.
  • the fine hollow protrusion 3 means a protrusion portion as a structure of the fine protrusion 1
  • the protrusion 3 ⁇ / b> A means an intermediate in the manufacturing process for forming the fine hollow protrusion 3.
  • the fine hollow protrusion 3 and the protrusion 3A may be different or the same with respect to the shape and the like.
  • the direction in which the base sheet 2A is transported (the longitudinal direction of the base sheet 2A) is the second direction, the Y direction, the direction orthogonal to the transport direction, and the first direction of the transported base sheet 2A. Will be described as the X direction, and the thickness direction of the conveyed substrate sheet 2A as the Z direction.
  • the protruding portion forming portion 10 includes a convex portion 11 including heating means (not shown).
  • the convex mold part 11 has a convex mold 110 corresponding to the number and arrangement of the fine hollow projections 3 of the fine projection tool 1 to be produced and the substantially outer shape thereof.
  • nine frustoconical convex molds 110 are provided.
  • the “convex mold part 11” is a member provided with a convex mold 110 that is a part that pierces the base sheet 2A.
  • the base is a flat plate-like base part. It has a structure having a plurality of convex molds 110 on the part.
  • the present invention is not limited to this, and the convex portion 11 including only the convex shape 110 may be used.
  • the manufacturing apparatus 100 of the first embodiment has no heating means other than the heating means (not shown) of the convex portion 11.
  • “no heating means other than the heating means of the convex portion 11” not only refers to the case of excluding other heating means, but also below the softening temperature of the base sheet 2A, Or it also includes the case where a means for heating below the glass transition temperature is provided. However, it is preferable not to include any other heating means.
  • the heating means (not shown) of the convex portion 11 is an ultrasonic vibration device.
  • belt-shaped base material sheet 2A is drawn
  • the convex part 11 is made to contact
  • the convex portion 11 has a shape having a truncated cone portion at the tip corresponding to the outer shape of the truncated cone-shaped fine hollow projection 3 of the fine projection tool 1 to be manufactured.
  • the convex portion 11 is arranged with its tip facing upward, and can move up and down at least in the thickness direction (Z direction). More specifically, in the manufacturing apparatus 100 according to the first embodiment, the convex portion 11 can be moved up and down in the thickness direction (Z direction) by an electric actuator (not shown), and the conveyance direction (Y direction).
  • Control of the operation of the convex portion 11 is controlled by a control means (not shown) provided in the manufacturing apparatus 100 of the first embodiment.
  • the manufacturing apparatus 100 of the first embodiment is an apparatus having the so-called box motion type projection forming part 10 that draws an endless track.
  • control of the heating means (not shown) of the convex part 11 is also controlled by the control means (not shown) provided in the manufacturing apparatus 100 of the first embodiment.
  • the base sheet 2A is a sheet composed of the base 2 and the fine hollow protrusions 3 of the fine protrusions 1 to be manufactured, and is formed including a thermoplastic resin.
  • the thermoplastic resin include poly fatty acid ester, polycarbonate, polypropylene, polyethylene, polyester, polyamide, polyamideimide, polyetheretherketone, polyetherimide, polystyrene, polyethylene terephthalate, polyvinyl chloride, nylon resin, acrylic resin, etc.
  • poly fatty acid esters are preferably used.
  • Specific examples of the polyfatty acid ester include polylactic acid, polyglycolic acid, and combinations thereof.
  • the base sheet 2A may be formed of a mixture containing hyaluronic acid, collagen, starch, cellulose and the like in addition to the thermoplastic resin.
  • the thickness of the base sheet 2A is equal to the thickness T2 of the base 2 of the fine projection 1 to be manufactured.
  • the convex portion 11 used in the protrusion forming step is viewed in a longitudinal section along the thickness direction (Z direction) as shown in FIG. A top 110t is provided.
  • the convex portion 11 includes a base portion and a plurality of convex molds 110 protruding from the base portion. Therefore, the “tip of the convex portion 11” is the tip of the convex die 110.
  • the tip of the convex mold 110 will be described.
  • type part 11 becomes a shape corresponding to the external shape of the fine hollow protrusion 3 which the fine protrusion tool 1 to manufacture has.
  • the “corresponding shape” includes not only a similar shape but also a shape classified into the same category such as a truncated cone shape.
  • the fine protrusion 1 manufactured using the manufacturing apparatus 100 according to the first embodiment has the top portion 3t at the center position CP of the tip portion 3U of the fine hollow protrusion 3, and thus the convex portion 11.
  • the top part 110t of the convex mold 110 is arranged at the center of the tip part 110U when the convex part 11 is viewed from the base sheet 2A side, that is, when the convex part 11 is viewed from the upper side in the thickness direction (Z direction). ing.
  • the top 110t of the convex mold 110 has an angle ⁇ of more than 60 degrees and an angle ⁇ of 90 degrees or more when viewed in a longitudinal section along the thickness direction (Z direction).
  • the angle ⁇ of the top part 110t of the convex part 11 is a state in which the section of the tip part 110U of the convex part 110 is enlarged by a predetermined magnification using a scanning electron microscope (SEM) or a microscope as shown in the SEM image shown in FIG. Observe and measure with.
  • SEM scanning electron microscope
  • the convex portion 11 has a height H2 (see FIG. 7) of the convex 110 that is the same as a height H1 (see FIG. 3) of the fine hollow protrusion 3 to be manufactured.
  • it is formed slightly higher, preferably 0.01 mm or more, more preferably 0.02 mm or more, and preferably 30 mm or less, more preferably 20 mm or less, specifically, preferably 0. It is 0.01 mm or more and 30 mm or less, More preferably, it is 0.02 mm or more and 20 mm or less.
  • the convex mold 110 of the convex mold part 11 has a tip diameter D1 (see FIG.
  • the convex mold 110 of the convex mold section 11 has a root diameter D2 of preferably 0.5 mm or more, more preferably 0.6 mm or more, and preferably 5 mm or less from the viewpoint that sufficient strength can be easily obtained. More preferably, it is 3 mm or less, specifically, preferably 0.5 mm or more and 5 mm or less, more preferably 0.6 mm or more and 3 mm or less.
  • the tip diameter D1 of the convex mold 110 of the convex mold part 11 is measured as follows.
  • a location where one side 110a is separated from the virtual straight line ILc is obtained as the first distal point 110a1
  • a location where the other side 110b is separated from the virtual straight line ILd is obtained as the second distal point 110b1.
  • the length D1 of the straight line connecting the first tip point 110a1 and the second tip point 110b1 thus determined is measured using a scanning electron microscope (SEM) or a microscope, and the measured length of the straight line is measured. Is the tip diameter D1 of the convex mold 110.
  • the convex mold 110 used in the protruding portion forming step is viewed in a longitudinal section along the thickness direction (Z direction) as shown in FIG.
  • Each of 110E is preferably formed in an arc shape.
  • the arc-shaped corner portion 110E of the convex portion 11 has a radius of curvature of 0.05 mm or more when viewed in a longitudinal section along the thickness direction (Z direction) as shown in FIG. More preferably 1 mm or more, more preferably 50 mm or less, further preferably 2 mm or less, specifically 0.05 mm or more and 50 mm or less, preferably 0.1 mm or more. More preferably, it has an angle of 2 mm or less.
  • the radius of curvature of the corner 110E of the convex portion 11 is enlarged by a predetermined magnification using a scanning electron microscope (SEM) or a microscope, as shown in the SEM image shown in FIG. Observe and measure in state.
  • SEM scanning electron microscope
  • the convex part 11 is formed of a high-strength material that is difficult to break.
  • Examples of the material of the convex part 11 include metals such as steel, stainless steel, aluminum, aluminum alloy, nickel, nickel alloy, cobalt, cobalt alloy, copper, copper alloy, beryllium copper, and beryllium copper alloy, or ceramic. .
  • the protruding portion forming portion 10 is a support member 12 that supports the base sheet 2A when the protruding portion 11 is pierced into the base sheet 2A as shown in FIG. have.
  • the support member 12 is arranged on the other surface 2U side of the base sheet 2A, and plays a role of making the base sheet 2A difficult to bend when the convex portion 11 is inserted from the one surface 2D side.
  • the support member 12 is preferably disposed in a portion other than the region where the convex portion 11 of the base sheet 2A is inserted, and on both sides along the transport direction (Y direction) of the base sheet 2A, although it may be a pair of plate-like members extending in parallel to the transport direction (Y direction), in the manufacturing apparatus 100 of the first embodiment, an opening that is a through hole at a position corresponding to the contact portion TP.
  • a punching plate which is an example of an open plate 121 is used.
  • the material constituting the support member 12 may be the same material as that of the convex portion 11, or may be formed of a synthetic resin or the like.
  • An opening plate 12 that is a support member having an open through hole is disposed at a position corresponding to the contact portion TP, and the base sheet 2A is supported when the convex portion 11 is pierced into the base sheet 2A.
  • the opening plate 12 is a plate having an opening 121 into which the convex mold 110 of the convex part 11 can be inserted.
  • the opening 121 is a through hole, but may be non-through.
  • the protruding portion forming section 10 includes a protruding portion having a plurality of protruding shapes corresponding to the number and arrangement of the plurality of fine hollow protrusions 3 and the outer shape of each fine hollow protrusion 3. I have to prepare.
  • the opening plate 12 is distribute
  • the base sheet 2 ⁇ / b> A is sandwiched between the convex portion 11 and the opening plate 12.
  • the opening plate 12 is provided with one through hole at a position corresponding to the contact portion TP of one convex mold 110 of the convex section 11 in the base sheet 2 ⁇ / b> A.
  • one through-hole may be arranged at a position corresponding to the contact portion TP of the plurality of convex molds 110.
  • the through hole is not particularly limited in shape when the opening plate 12 is viewed from the upper surface side, but is formed in a circular shape in the manufacturing apparatus 100 shown in FIG.
  • the shape of the opening plate 12 is not particularly limited, but is formed in a plate shape in the manufacturing apparatus 100 shown in FIG.
  • the length of the plate-shaped opening plate 12 in the Y direction is substantially the same as the length of the convex portion 11 in the Y direction
  • the length of the X direction is substantially the same as the length of the convex portion 11 in the X direction.
  • Such a plate-shaped opening plate 12 sandwiches the base material sheet 2 ⁇ / b> A conveyed in the Y direction, and the operation of the box motion type convex portion 11 and the target operation. It is designed to draw an endless track with a box motion formula.
  • the box motion type opening plate 12 is arranged adjacent to the other surface 2U of the base sheet 2A in the thickness direction (Z direction) and is parallel to the base sheet 2A in the transport direction (Y direction). It is possible.
  • the movement speed of the opening plate 12 in the conveyance direction (Y direction) corresponds to the movement speed of the convex portion 11 in the conveyance direction (Y direction), and is provided in the manufacturing apparatus 100 shown in FIG. It is controlled by means (not shown).
  • the convex part 110 is ultrasonically vibrated with an ultrasonic vibration apparatus, and the contact part which is contacting the convex mold 110 is shown. Only the TP generates heat due to friction to soften the contact portion TP. Then, while softening the contact portion TP, as shown in FIGS. 9 (b) to 9 (c), from one surface 2D side (lower surface side) to the other surface 2U side (upper surface side), as shown in FIGS. Then, the convex portion 11 is raised and stabbed into the base sheet 2A to form a protrusion 3A that protrudes from the other surface 2U side (upper surface side) of the base sheet 2A.
  • the frequency of ultrasonic vibration by the wave vibration device of the convex mold 110 is preferably 10 kHz or more, more preferably 15 kHz or more from the viewpoint of forming the protrusion 3A. And, it is preferably 50 kHz or less, more preferably 40 kHz or less, specifically, preferably 10 kHz or more and 50 kHz or less, more preferably 15 kHz or more and 40 kHz or less. Further, regarding the ultrasonic vibration by the convex 110 wave vibration device, the amplitude thereof is preferably 1 ⁇ m or more, more preferably 5 ⁇ m or more, and preferably 60 ⁇ m or less from the viewpoint of formation of the protrusion 3A.
  • the frequency and amplitude of the ultrasonic vibration of the convex mold 110 may be adjusted within the above-described range.
  • the insertion speed for piercing the convex mold 110 into the base sheet 2A is excessively softened if the resin is too slow, and insufficiently softened if it is too fast. It is 0.1 mm / second or more, more preferably 1 mm / second or more, and preferably 1000 mm / second or less, more preferably 800 mm / second or less, specifically preferably 0.1 mm / second. It is 1000 mm / second or less, and more preferably 1 mm / second or more and 800 mm / second or less.
  • the softening time which is the time from stopping the rising of the convex mold 110 in the ultrasonic vibration state and transporting it to the next process (cooling process) while the convex mold part 11 is stuck inside the protrusion 3A, is too long. From the viewpoint of compensating for insufficient softening, it is preferably 0 second or longer, more preferably 0.1 second or longer, and preferably 10 seconds or shorter, more preferably 5 seconds or shorter, Specifically, it is preferably 0 second or longer and 10 seconds or shorter, and more preferably 0.1 second or longer and 5 seconds or shorter.
  • the insertion height of the convex mold 110 inserted into the base sheet 2A is preferably 0.01 mm or more, more preferably 0.02 mm or more, and preferably 10 mm from the viewpoint of efficiently forming the protrusion 3A. It is below, More preferably, it is 5 mm or less, Specifically, Preferably it is 0.01 mm or more and 10 mm or less, More preferably, it is 0.02 mm or more and 5 mm or less.
  • the “insertion height” is the distance between the top 110t of the convex mold 110 and the other surface 2U (upper surface) of the base sheet 2A in a state where the convex mold 110 is most inserted into the base sheet 2A. Means distance.
  • the insertion height in the protruding portion forming step refers to the other in the state in which the protruding portion 110 is deeply inserted in the protruding portion forming step and the protruding portion 11 protrudes from the other surface 2U of the base sheet 2A. It is the distance from the surface 2U to the top 110t of the convex mold 110 measured in the vertical direction.
  • the cooling unit 20 is installed downstream of the protrusion forming unit 10.
  • the cooling unit 20 includes a cold air blowing device 21.
  • the cold air blower 21 is used to cool the protruding portion 110 inside the protruding portion 110 (cooling step).
  • the cold air blowing device 21 covers the entire other surface 2U side (upper surface side) and one surface 2D side (lower surface side) of the belt-shaped base sheet 2A being conveyed.
  • the belt-shaped base sheet 2A is conveyed in the conveyance direction (Y direction).
  • an air blowing port 22 see FIG.
  • the protruding portion 11 is inserted into the protrusion 3 ⁇ / b> A in the tunnel of the cold air blowing device 21 using the box motion type protrusion forming portion 10.
  • the base sheet 2A is transported in parallel to the transport direction (Y direction), and is arranged on the other surface 2U side (upper surface side) of the base sheet 2A in the tunnel as shown in FIG. Cool air is blown from the blower opening 22 thus cooled, and the protrusion 110 is cooled while the convex mold 110 is stuck inside.
  • the ultrasonic vibration by the ultrasonic device of the convex mold 110 may be in a continuous state or stopped, but from the viewpoint of keeping the shape of the protrusion 3A constant without excessive deformation, It is preferably stopped.
  • the temperature of the cold air to be blown is preferably ⁇ 50 ° C. or higher, more preferably ⁇ 40 ° C. or higher, and preferably 26 ° C. or lower, more preferably 10 ° C. or lower, from the viewpoint of forming the protrusion 3A. Specifically, it is preferably ⁇ 50 ° C. or higher and 26 ° C. or lower, and more preferably ⁇ 40 ° C. or higher and 10 ° C. or lower.
  • the cooling time for cooling by blowing cold air is preferably 0.01 seconds or longer, more preferably 0.5 seconds or longer, and preferably 60 seconds, from the viewpoint of compatibility between the moldability of the protrusion 3A and the processing time. 2 seconds or less, more preferably 30 seconds or less, specifically, preferably 0.01 seconds or more and 60 seconds or less, and more preferably 0.5 seconds or more and 30 seconds or less.
  • a release unit 30 is installed downstream of the cooling unit 20.
  • the convex mold 110 is pulled out from the inside of the protrusion 3A to form the precursor 1A of the fine protrusion 1 (release). Process).
  • the release process of the first embodiment from the one surface 2D side (lower surface side) of the base sheet 2A, as shown in FIG.
  • the convex part 110 is removed, and the precursor 1A of a strip-shaped fine protrusion that becomes the hollow fine protrusion 1 inside. Form.
  • a cutting unit 40 is installed downstream of the release unit 30.
  • the cutting unit 40 includes a cutter unit 41 having a cutter blade at the tip and an anvil unit 42.
  • the cutter blade of the cutter unit 41 is formed wider than the entire width (length in the X direction) of the precursor 1A of the band-shaped fine projection tool.
  • the precursor 1A of the band-shaped fine projection tool is transported between the pair of cutter parts 41 and the anvil part 42, and the protrusions adjacent in the transport direction (Y direction).
  • the sheet-like fine projection 1 is continuously manufactured by cutting with the cutter blade of the cutter part 41 between the parts 3A and 3A.
  • the cutting of the precursor 1 ⁇ / b> A of the band-shaped fine projection tool may be performed so as to extend in the lateral direction of each fine projection tool 1, and can be performed linearly across the lateral direction of each fine projection tool 1, for example. Or it can cut so that a cutting line may draw a curve. In any case, it is preferable to employ a cutting pattern that does not cause trimming by cutting.
  • the re-pitch part 50 is installed downstream of the cutting part 40.
  • the re-pitch unit 50 includes a plurality of rollers 51 that are arranged so that their rotation axes are parallel to each other, and an endless conveyance belt 52 that is spanned between the rollers 51. have.
  • a suction box 53 is provided inside the conveyor belt 52.
  • the conveyor belt 52 is provided with a plurality of through holes (not shown) for sucking air from the outside to the inside of the circuit track by starting the suction box 53.
  • the conveyance speed of the conveyance belt 52 is faster than the conveyance speed of the base sheet 2 ⁇ / b> A up to the cutting unit 40.
  • the microneedle array 1M as the microprojection tool 1 of each leaf is continuously sucked by the suction box 53 through a through hole (not shown), and then on the fast conveying belt 52.
  • the microneedle array 1M as the fine projection tool 1 is placed and rearranged at a predetermined distance by increasing the distance between the adjacent microneedle arrays 1M and 1M in the transport direction (Y direction). To manufacture.
  • the convex portion including the top portion 110t having an angle of more than 60 degrees and not more than 180 degrees.
  • the microprojection tool 1 can be manufactured only by a simple process of using the mold 110 in the projecting portion forming process, cost increase can be suppressed, and the microprojection tool 1 can be manufactured efficiently and continuously. it can.
  • the convex part 11 including the convex mold 110 having both corners 110E and 110E formed in an arc shape is used in the projecting part forming step. It is possible to efficiently manufacture a high-precision fine projection tool 1 having a high accuracy and having a tip whose ratio W / R of the width W of the tip is 0.1 or more and 10 or less.
  • the ultrasonic device is used only at the contact portion TP of the base sheet 2 ⁇ / b> A with which the convex mold 110 is contacted. Accordingly, since the convex mold 110 is ultrasonically vibrated and only the contact portion TP is softened, the fine protrusion 1 can be manufactured continuously and efficiently with energy saving.
  • the ultrasonic vibration device is used as the heating means (not shown) of the convex mold 110, it is not always necessary to provide the cold air blowing device 21, and the ultrasonic vibration device It can also be cooled simply by turning off the vibration.
  • the ultrasonic vibration is used as the heating means, the microprojection tool 1 can be manufactured at a high speed with simplification of the apparatus.
  • the portion of the base sheet 2A that is not in contact with the convex portion 11 heat is more difficult to be transmitted, and cooling is efficiently performed by turning off the ultrasonic vibration application, so deformation other than the contact portion TP. Therefore, it is possible to manufacture the fine protrusion 1 with high accuracy.
  • the manufacturing apparatus 100 uses the control means (not shown) to operate the convex portion 11, the heating conditions of the heating means (not shown) included in the convex 110, and the cold air blower. 21 cooling temperature and cooling time are controlled. Therefore, the amount of insertion of the convex mold 110 into the base sheet 2A can be easily changed by controlling the insertion height of the convex mold 110, for example, in the protrusion forming step by a control means (not shown). The protrusion height H1 of the fine protrusion 1 to be performed can be controlled.
  • the fine projection The thickness T1 and the like of the fine hollow protrusion 3 constituting the tool 1 can be freely controlled.
  • the shape of the fine projection tool 1 can be freely controlled by controlling at least one of the insertion speed of the mold 110 into the base sheet 2A, the shape of the convex mold portion 11, and the cooling conditions in the cooling step. .
  • the base plate 2 ⁇ / b> A is formed using the opening plate 12 that is a support member on the other surface 2 ⁇ / b> U side (upper surface side) of the base sheet 2 ⁇ / b> A.
  • the non-processed part is supported, the convex part 11 is brought into contact from the one surface 2D side (lower surface side) of the part not supported by the support member 12 in the base material sheet 2A, and the contact part TP is softened by heat.
  • a protrusion 3A is formed.
  • the heating temperature of the base sheet 2A by the convex mold 110 is from the viewpoint of the formation of the projection 3A.
  • the glass transition temperature (Tg) of the base sheet 2A to be used is preferably not lower than the melting temperature, and particularly preferably not lower than the softening temperature and lower than the melting temperature. More specifically, the heating temperature is preferably 30 ° C. or higher, more preferably 40 ° C. or higher, and preferably 300 ° C. or lower, more preferably 250 ° C. or lower. It is not less than 300 ° C and more preferably not less than 40 ° C and not more than 250 ° C.
  • the said heating temperature is applied as a temperature range of the part of the base material sheet 2A which contacted the convex mold
  • a heater device can be used as the heating means.
  • the heating temperature of the convex portion 11 may be adjusted within the above-described range.
  • the “glass transition temperature (Tg)” is measured by the following method, and the softening temperature is measured by JIS K-7196 “Softening temperature test method by thermomechanical analysis of thermoplastic film and sheet”. To follow.
  • the “glass transition temperature (Tg) of the base sheet 2A” means the glass transition temperature (Tg) of the constituent resin of the base sheet 2A.
  • the heating temperature of the base sheet 2A by the heating means is at least the lowest glass transition temperature (Tg) among the plurality of glass transition temperatures (Tg). It is preferable that it is above, and it is more preferable that it is higher than the highest glass transition temperature (Tg) among the plurality of glass transition temperatures (Tg).
  • the “softening temperature” of the base sheet 2A is the same as the glass transition temperature (Tg).
  • the heating temperature of the base sheet 2A by the heating means is at least the plurality of softening temperatures.
  • the temperature is preferably the lowest softening temperature or higher, and more preferably the highest softening temperature or higher among the plurality of softening temperatures.
  • the heating temperature of the base sheet 2A by the heating means is less than the lowest melting point among the plurality of melting points. Is preferred.
  • Tg glass transition temperature
  • the amount of heat is measured using a DSC measuring machine to determine the glass transition temperature.
  • the measuring instrument uses a differential scanning calorimeter (Diamond DSC) manufactured by Perkin Elmer. 10 mg of a test piece is collected from the base sheet 2A. The measurement conditions are that 20 ° C. is isothermal for 5 minutes, and then the temperature is increased from 20 ° C. to 320 ° C. at a rate of 5 ° C./min to obtain a DSC curve of horizontal axis temperature and vertical axis calorie. And glass transition temperature Tg is calculated
  • the manufacturing method of the fine projection tool 1 of 2nd Embodiment also uses the ultrasonic vibration apparatus as a heating means (not shown) of the convex part 11 similarly to the manufacturing method of the fine projection tool 1 of 1st Embodiment. .
  • the fine hollow protrusion 3 of the fine projection tool 1 of the first embodiment has a truncated cone shape having a curved top 3t, but the fine hollow protrusion 3 of the second embodiment is shown in FIG. As shown in FIG. 2, the tip has a flat columnar shape.
  • the surface of the fine hollow protrusion 3 of the second embodiment does not communicate with the internal space, and the surface of the fine hollow protrusion forms a continuous surface.
  • the convex portion 11 used in the protruding portion forming step is viewed from the base sheet 2A side, that is, the convex portion 11 is in the thickness direction (Z direction).
  • the top 110t of the convex mold 110 is arranged at the center of the tip 110U.
  • the convex 110 is viewed in a longitudinal section along the thickness direction (Z direction) at the top 110t, and the angle of the top 110t is 180 degrees.
  • the convex mold 110 of the convex mold portion 11 has a cylindrical shape corresponding to the cylindrical fine hollow protrusion 3 of the fine protrusion tool 1 of the second embodiment. .
  • the convex mold 110 of the convex mold part 11 is a circle having a diameter D3 as viewed from the upper side in the thickness direction (Z direction).
  • the diameter D3 (see FIG. 12) is preferably 0.5 mm or more, more preferably 0.6 mm or more, and preferably 5 mm or less, more preferably 1 mm or less, specifically preferably It is 0.5 mm or more and 5 mm or less, More preferably, it is 0.6 mm or more and 1 mm or less.
  • type part 11 used at a projection part formation process becomes a column shape, and as shown in FIG. 12, it follows a thickness direction (Z direction).
  • the two corners 110E and 110E are formed at right angles as viewed in a longitudinal section. From the viewpoint of forming the projection 3A in which each of the corners 1E and 1E is formed in an arc shape, the both corners 110E and 110E, Each of 110E may be formed in a circular arc shape.
  • the radius of curvature is preferably 0.005 mm or more, more preferably 0.01 mm or more, and 1 mm or less. Preferably 0.5 mm or less, more preferably 0.005 mm or more and 1 mm or less, and still more preferably 0.01 mm or more and 0.5 mm or less. .
  • the curvature radius of the corner portion 110E of the convex portion 11 is measured by observing the longitudinal section of the tip portion 110U of the convex portion 110 with a scanning electron microscope (SEM) or a microscope magnified by a predetermined magnification.
  • the convex mold 110 is ultrasonically vibrated by the ultrasonic vibration device at the contact portion TP to come into contact with the convex mold 110. Heat generated by friction is generated only in the abutting portion TP to soften the abutting portion TP. Then, while softening the contact portion TP, as shown in FIGS. 11 (b) to 11 (c), from one surface 2D side (lower surface side) of the base sheet 2A to the other surface 2U side (upper surface side). Then, the convex portion 11 is raised and stabbed into the base sheet 2A to form a protrusion 3A that protrudes from the other surface 2U side (upper surface side) of the base sheet 2A.
  • the other surface of the base sheet 2A with the convex portion 11 stabbed inside the protruding portion 3A. Cool air is blown from the blower port 22 arranged on the 2U side (upper surface side), and cooling is performed while the convex mold 110 is stuck inside the protruding portion 3A.
  • the convex portion 11 is lowered from the one surface 2D side (lower surface side) of the base sheet 2A, and the convex portion 110 is stabbed inside the protruding portion 3A.
  • the mold 110 is pulled out to form a band-shaped fine projection precursor 1A that becomes the hollow fine projection 1 inside.
  • the single blade fine protrusion 1 having the fine hollow protrusions 3 is continuously cut by the cutter blade of the cutter part 41, and the re-pitch part.
  • the fine projection tool 1 is manufactured by rearrangement.
  • the convex portion 11 including the top portion 110t having an angle of 180 degrees is provided.
  • the microprojection tool 1 can be manufactured by only a simple process used in the projecting portion forming step, the cost increase can be suppressed, and the microprojection tool 1 can be manufactured efficiently and continuously.
  • the convex portion 11 Since the fine projection tool 1 manufactured using the manufacturing apparatus 100 of the first embodiment and the second embodiment has the apex portion 1t at the center position CP of the tip portion 1U, the convex portion 11 has a convex shape.
  • the top part 110t of the mold 110 is arranged at the center of the tip part 110U when the convex part 11 is viewed from the base sheet 2A side, that is, when the convex part 11 is viewed from the upper side in the thickness direction (Z direction). However, it does not have to be the center of the distal end portion 110U, and it is only necessary that the distal end portion 110U is arranged.
  • fine projection tool 1 of the first embodiment nine frustoconical fine protrusions 3 are arranged on the upper surface of the sheet-like base 2, but there is one fine hollow protrusion 3. You may do it.
  • the box-motion type convex-shaped part 11 which draws an endless track is used, the convex-shaped part which can move only up and down in the thickness direction (Z direction) 11 may be used to manufacture the fine projection tool 1.
  • the manufacturing apparatus 100 of the said 1st Embodiment or 2nd Embodiment is a plate-shaped which supports 2 A of base material sheets, when piercing the convex-shaped part 11 in 2 A of base material sheets.
  • the supporting member 12 what is necessary is just to arrange
  • the manufacturing apparatus 100 of the said 1st Embodiment or 2nd Embodiment inserts the base material sheet 2A toward the upper direction from the downward direction as shown in FIG.
  • the positional relationship between the convex portion 11 and the support member 12 with respect to the sheet 2A and the insertion direction are not limited thereto, and the fine protrusion 1 may be formed from the upper side to the lower side.
  • the manufacturing apparatus 100 of the first embodiment or the second embodiment uses ultrasonic waves as the heating means of the convex mold 110
  • other known heating means such as a heater may be used instead.
  • the present invention further discloses the following method for manufacturing a fine projection tool.
  • a microprojection for skin irritation comprising a hollow micro hollow projection on the base, the longitudinal cross section along the thickness direction at the center position of the tip of the micro hollow projection, the micro hollow projection of the micro hollow projection A fine projection tool for skin stimulation, the tip of which is curved outwardly or flat.
  • ⁇ 2> When viewed from a longitudinal section along the thickness direction at the center position of the tip of the fine hollow projection, the curvature of the fine hollow projection when the width of the tip of the fine hollow projection is W and the radius of curvature of each of the corners is R.
  • ⁇ 3> The fine projection tool for skin stimulation according to ⁇ 1> or ⁇ 2>, wherein the plurality of fine hollow projections are arranged on the base.
  • the fine protrusion tool for skin irritation according to any one of ⁇ 1> to ⁇ 3>, further comprising an adhesive means so that the surface on which the fine hollow protrusion is arranged is fixed to the skin.
  • the width of the tip of the fine hollow protrusion is 0.5 mm or more, preferably 0.5 mm or more and 5 mm or less, preferably 0.6 mm or more and 1 mm, according to any one of the above ⁇ 1> to ⁇ 4>
  • Fine projection tool for skin irritation ⁇ 6>
  • the curvature of the fine hollow projection when the width of the tip of the fine hollow projection is W and the radius of curvature of each of the corners is R.
  • the fine protrusion for skin irritation according to any one of ⁇ 1> to ⁇ 6>, wherein the radius R is 0.05 mm or more and 50 mm or less, preferably 0.1 mm or more and 2 mm or less.
  • ⁇ 9> The skin according to any one of ⁇ 1> to ⁇ 8>, wherein the fine hollow protrusion has an average thickness of 0.005 mm to 1.0 mm, preferably 0.01 mm to 0.5 mm.
  • ⁇ 10> The skin irritation according to any one of ⁇ 1> to ⁇ 9>, wherein the base has a thickness of 0.01 mm to 1.0 mm, preferably 0.02 mm to 0.7 mm.
  • Fine projection tool. ⁇ 11> A plurality of the fine hollow protrusions are arranged on the base, and the fine hollow protrusions have uniform longitudinal center-to-center distances and lateral center-to-center distances as described in ⁇ 1> to ⁇ 10>.
  • the distance between the centers of the fine hollow protrusions in the vertical direction is 0.01 mm or more and 10 mm or less, preferably 0.05 mm or more and 5 mm or less, and the distance between the centers of the fine hollow protrusions in the horizontal direction is 0.01 mm or more and 10 mm or less.
  • the pressure-sensitive adhesive sheet has a base sheet wider than the area of the base and a pressure-sensitive adhesive coated on the entire surface of the base sheet, and the fine protrusion for skin irritation according to ⁇ 13> Ingredients.
  • the filler is a functional agent.
  • the method for producing a skin irritation fine projection comprising heating means from one side of a base sheet formed with a thermoplastic resin.
  • a projecting portion protruding from the other surface side of the base sheet while the convex portion is abutted and the corresponding contact portion of the base sheet is softened by heat while the convex portion is pierced into the base sheet A projecting portion forming step for forming the projecting portion, a cooling step for cooling the projecting portion with the projecting portion pierced inside the projecting portion, and the projecting mold from the inside of the projecting portion after the cooling step.
  • a release step of forming the fine projection tool by pulling out the portion, and the convex portion used in the projection portion formation step has a vertical cross-sectional view along the thickness direction and has a tip portion of more than 60 degrees 180 degrees.
  • Manufacturing method of fine protrusion for skin irritation provided with top having angle of less than or equal to degree .
  • the top of the convex part used in the protrusion part forming step is arranged at the center of the tip part when the convex part is viewed from the base sheet side, and the convex part used in the protrusion part forming step is provided.
  • the mold part is a method for producing a fine protrusion for skin irritation according to ⁇ 19>, wherein each of the corner parts is formed in an arc shape when viewed from a longitudinal section along the thickness direction at the top part.
  • the top part of the convex part used in the projection part forming step is arranged at the center of the tip part when the convex part is viewed from the base sheet side, and the convex part is at the top part.
  • the convex portion includes a top portion having an angle of 90 degrees to 150 degrees at a tip.
  • the heating means is ultrasonic vibration.
  • the convex portion is composed of a base portion and a plurality of convex shapes protruding therefrom.
  • ⁇ 25> The method for producing a fine protrusion for skin irritation according to ⁇ 24>, wherein the height of the convex mold is the same as or slightly higher than the height of the fine hollow protrusion to be produced.
  • ⁇ 26> The method for producing a fine protrusion for skin irritation according to ⁇ 24> or ⁇ 25>, wherein the convex shape has a height of 0.01 mm to 30 mm, preferably 0.02 mm to 20 mm.
  • ⁇ 27> Any one of the above ⁇ 24> to ⁇ 26>, wherein the heating temperature of the base sheet by the convex mold is not lower than the glass transition temperature of the base sheet and lower than the melting temperature, preferably not lower than the softening temperature and lower than the melting temperature.
  • the said heating temperature is 30 degreeC or more and 300 degrees C or less, Preferably it is 40 degreeC or more and 250 degrees C or less,
  • the said convex type is circular shape seeing from the upper side of the thickness direction, The diameter is 0.5 mm or more and 5 mm or less, Preferably it is 0.6 mm or more and 1 mm or less.
  • the present invention it is possible to give a stimulus by applying the skin irritation microprojection tool to the skin non-invasively. Moreover, according to this invention, the fine protrusion tool for skin irritation can be manufactured efficiently and at high speed.

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  • Health & Medical Sciences (AREA)
  • Rehabilitation Therapy (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Finger-Pressure Massage (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

Un outil à fines saillies (1) destiné à être utilisé pour la stimulation de la peau selon la présente invention est pourvu de fines saillies creuses ayant chacune un intérieur creux, et peut stimuler la peau. Dans l'outil à fines saillies (1) destiné à être utilisé pour la stimulation de la peau, la largeur W de la pointe de chacune des saillies creuses fines est supérieure à 0,5 mm et la pointe de chacune des saillies creuses fines est incurvée vers l'extérieur sous une forme convexe lorsqu'une section transversale verticale de l'outil est observée. Un procédé de fabrication de l'outil à fines saillies (1) destiné à être utilisé pour la stimulation de la peau comprend une étape de formation de saillies consistant à amener un moule convexe (11) équipé d'un moyen de chauffage en contact avec un côté de surface (2D) d'une feuille de base (2A) contenant une résine thermoplastique, puis perforer le moule convexe (11) à travers la feuille de base (2A) tout en ramollissant les parties de contact (TP) avec de la chaleur pour former des saillies (3A) qui font saillie à partir de l'autre côté de surface (2U) de la feuille de base (2A). Le moule convexe (11) à utiliser dans l'étape de formation de saillies a, au niveau des pointes (110U) de celui-ci, des sommets (110t) ayant chacun un angle supérieur à 60 degrés et inférieur ou égal à 180 degrés lorsqu'une section transversale verticale du moule convexe (11) est observée.
PCT/JP2017/043041 2016-12-06 2017-11-30 Outil à fines saillies destine à être utilisé pour la stimulation de la peau, et son procédé de fabrication Ceased WO2018105480A1 (fr)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024053625A1 (fr) * 2022-09-08 2024-03-14 コスメディ製薬株式会社 Système d'application locale

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7349342B2 (ja) * 2019-12-16 2023-09-22 花王株式会社 突起具の製造方法
JP7758481B2 (ja) * 2021-06-09 2025-10-22 花王株式会社 皮膚刺激用突起具
JP7664095B2 (ja) * 2021-06-09 2025-04-17 花王株式会社 突起具の使用方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53124356U (fr) * 1977-03-11 1978-10-03
JPS54104207U (fr) * 1977-12-31 1979-07-23
JPS59104932A (ja) * 1982-12-08 1984-06-18 株式会社エマンテ医療器製作所 熱圧縮成型シ−ト
JPS59124815A (ja) * 1982-12-30 1984-07-19 Asahi Chem Ind Co Ltd 熱可塑性樹脂の配向成形法
JPH0924519A (ja) * 1995-07-12 1997-01-28 Hajime Nitsukou 熱可塑性樹脂製品のゲートレス成形方法とその成形装置
JP3132342U (ja) * 2007-03-22 2007-06-07 寶琴 林 マッサージ器の構造
JP2009233267A (ja) * 2008-03-28 2009-10-15 Toppan Printing Co Ltd 押圧冶具及びその製造方法
JP3190164U (ja) * 2014-02-07 2014-04-17 春明 于 熱波マッサージ器

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60145849U (ja) * 1984-03-09 1985-09-27 日本ヘルス工業株式会社 背当て具
KR960006864Y1 (ko) * 1993-09-03 1996-08-08 유태우 지압구가 부착된 장갑
JP2008012101A (ja) * 2006-07-06 2008-01-24 Ube Nitto Kasei Co Ltd 足裏マッサージ用シートまたはシート積層物
JP2015205155A (ja) * 2014-04-08 2015-11-19 株式会社グレース 貼付治療具

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53124356U (fr) * 1977-03-11 1978-10-03
JPS54104207U (fr) * 1977-12-31 1979-07-23
JPS59104932A (ja) * 1982-12-08 1984-06-18 株式会社エマンテ医療器製作所 熱圧縮成型シ−ト
JPS59124815A (ja) * 1982-12-30 1984-07-19 Asahi Chem Ind Co Ltd 熱可塑性樹脂の配向成形法
JPH0924519A (ja) * 1995-07-12 1997-01-28 Hajime Nitsukou 熱可塑性樹脂製品のゲートレス成形方法とその成形装置
JP3132342U (ja) * 2007-03-22 2007-06-07 寶琴 林 マッサージ器の構造
JP2009233267A (ja) * 2008-03-28 2009-10-15 Toppan Printing Co Ltd 押圧冶具及びその製造方法
JP3190164U (ja) * 2014-02-07 2014-04-17 春明 于 熱波マッサージ器

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024053625A1 (fr) * 2022-09-08 2024-03-14 コスメディ製薬株式会社 Système d'application locale

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