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WO2018172332A1 - Composition nettoyante moussante contenant des polymères polyquaternium-16 - Google Patents

Composition nettoyante moussante contenant des polymères polyquaternium-16 Download PDF

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Publication number
WO2018172332A1
WO2018172332A1 PCT/EP2018/056974 EP2018056974W WO2018172332A1 WO 2018172332 A1 WO2018172332 A1 WO 2018172332A1 EP 2018056974 W EP2018056974 W EP 2018056974W WO 2018172332 A1 WO2018172332 A1 WO 2018172332A1
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WIPO (PCT)
Prior art keywords
cleaning preparation
group
weight
polyquaternium
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2018/056974
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German (de)
English (en)
Inventor
Katrin Counradi
Horst Argembeaux
Bernd Traupe
Andreas Firyn
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Beiersdorf AG
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Beiersdorf AG
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Publication of WO2018172332A1 publication Critical patent/WO2018172332A1/fr
Anticipated expiration legal-status Critical
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
    • A61K8/8182—Copolymers of vinyl-pyrrolidones. Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/596—Mixtures of surface active compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/70—Biological properties of the composition as a whole

Definitions

  • the present invention relates to a cosmetic cleansing preparation containing
  • Polyquaternium-16 polymers anionic surfactants and amphoteric and / or zwitterionic surfactants.
  • the cleaning preparation allows effective deposition of anti-microbial Polyquaternium-16 polymers on the skin.
  • cosmetic products not only look beautiful and attractive, they also make a significant contribution to increasing self-esteem and well-being. Demenbachend the most diverse cosmetic products for daily cleaning and care of the skin are used.
  • a crucial parameter is the removal and / or the suppression of the
  • S. aureus Staphylococcus aureus
  • S. aureus Staphylococcus aureus
  • S. aureus also produces bacterial superantigens that maintain and aggravate atopic dermatitis.
  • the Corynebacterium jeikeium is one of the main causes of the typical
  • Deodorants are products which contain special anti-microbial agents which reduce the growth of bacteria such as Corynebacterium jeikeium or Staphylococcus epidermidis. Deodorants are therefore usually applied after cleaning the skin and remain there to develop their antibacterial effect in the long term.
  • WO 2016012417 A2 discloses that complex quaternary ammonium polymer compounds known under the INCI nomenclature designation Polyquaternium-16, a surprising have strong deodorization or anti-microbial activity against Corynebacterium jeikeium or Staphylococcus epidermidis.
  • Polyquaternium-16 also has an anti-microbial effect against the growth of the bacterium Staphylococcus aureus.
  • Polyquaternium-16 is not anti-adhesive and thus does not prevent the adhesion of bacteria to surfaces.
  • Cleaning preparations containing polyquaternium-16 polymers are known from the document WO 9850007 A1.
  • the preparations contain anionic surfactants and amphoteric and / or zwitterionic surfactants, the anionic surfactants being used in excess over the amphoteric and / or zwitterionic surfactants. An indication of the present invention is therefore not apparent from this document.
  • Polyquaternium-16 is a cationic polymeric quaternary ammonium salt based on the monomers methylvinylimidazolium chloride and vinylpyrrolidone.
  • Polyquaternium-16 in aqueous solution can be obtained under the trade name Luviquat from FA. BASF are related.
  • the Polyquaternium-16 commercial products listed in Table 1 differ in the respective solids content, the molecular weight, the ratio of the weight fraction of vinylpyrrolidone (VP) to the weight fraction of the quaternized
  • cosmetic cleansing preparations which allow the washing process to effectively deposit anti-microbial agents, such as Polyquaternium-16, on the skin.
  • anti-microbial agents such as Polyquaternium-16
  • the anti-microbial agents should remain on the skin after washing for an extended period of time and thus reduce the growth of bacteria.
  • the cosmetic cleaning preparations contain mostly anionic surfactants.
  • anionic surfactants In combination with cationic active ingredients, it is therefore possible, in particular with anionic surfactants, for complex formation and deactivation of the active ingredients.
  • the interaction of the cationic active ingredients with anionic surfactants often leads to unstable or cloudy cosmetic preparations.
  • the anti-microbial cosmetic cleansing preparations should have a particularly low irritation potential.
  • the invention relates to a cosmetic cleaning preparation containing
  • the inventive cosmetic characterized in that the weight ratio of the anionic surfactants to the amphoteric and / or zwitterionic surfactants 1: 2 to 1: 20 and preferably 1: 2.5 to 1: 15.
  • Cosmetic cleaning preparation according to the invention for the reduction of Corynebacterium jeikeium, Staphylococcus epidermidis and / or Staphylococcus aureus on the skin.
  • Another object of the present invention is a method for the deposition of Polyquaternium-16 on the skin, characterized in that the inventive
  • Cleaning preparation is applied to wet skin and rinsed again from the skin with water within a period of 5 seconds to 5 minutes.
  • skin refers exclusively to the human skin.
  • cationic charge density refers to the ratio of the number of positive charges on a monomer unit making up the polymer to the molecular weight of the monomer unit.
  • the charge density is expressed in meq / g (milli-equivalents per gram).
  • normal conditions means 20 ° C., 1013 hPa and a relative atmospheric humidity of 50%
  • Anionic surfactants generally have carboxylate, sulfate or sulfonate groups as functional groups, and in aqueous solution they form negatively charged ones in an acidic or neutral medium organic ions.
  • Anionic surfactants to be used advantageously according to the invention are sulfuric acid esters, such as - alkyl ether sulfate, for example sodium, ammonium, magnesium, MI PA, ⁇ -
  • Alkyl sulfates for example, sodium, ammonium and TEA lauryl sulfate
  • Acyl isethionates e.g. Sodium / ammonium cocoyl isethionate
  • Alkyl sulfonates for example sodium coconut monoglyceride sulfate, sodium C12-14
  • Olefinsulfonate sodium lauryl sulfoacetate and magnesium PEG-3 cocamide sulfate, Sulfosuccinates, for example dioctyl sodium sulphosuccinate, disodium laureth sulphosuccinate, disodium lauryl sulphosuccinate, disodium undecylenamido MEA sulphosuccinate and PEG-5 lauryl citrate sulphosuccinate;
  • Further advantageous anionic surfactants are acylamino acids and their salts, such as
  • Acylglutamates for example, sodium acylglutamate, di-TEA-palmitoylaspartate and sodium caprylic / capric glutamate;
  • Acyl peptides for example palmitoyl-hydrolyzed milk protein, sodium cocoyl-hydrolysed soy protein and sodium / potassium cocoyl-hydrolyzed collagen,
  • Sarcosinates for example myristoyl sarcosine, TEA-lauroyl sarcosinate, sodium lauroyl sarcosinate and sodium cocoyl sarcosinate;
  • Taurates for example, sodium lauroyl taurate and sodium methyl cocoyl taurate
  • Carboxylic acids for example, lauric acid, aluminum stearate, magnesium alkoxide and zinc undecylenate;
  • Ester carboxylic acids for example, calcium stearoyl lactylate, laureth-6-citrate, and sodium PEG-4 lauramide carboxylate;
  • Ether carboxylic acids for example, sodium laureth-13 carboxylate and sodium PEG-6 cocamide carboxylate; and phosphoric acid esters and salts such as DEA-oleth-10-phosphate and
  • anionic surfactants are selected from the group of the alkyl ether sulfates and the alkyl sulfates according to the general formula (I):
  • R is a linear or branched Ce-C-ie-alkyl radical or mixtures of different linear or branched Ce-Cie-alkyl radicals
  • R 1 is methyl, ethyl or mixtures thereof
  • M 4 is a cation selected from the group consisting of alkali metals, HV and is HNR 2 3 +, wherein R 2 is selected from the group consisting of linear or branched alkyl, CH2CH2OH, and CH 2 CH (OH) CH 3; x is an integer number in the range of 0-3;
  • y is an integer number in the range 0-10;
  • z is an integer number in the range 0 - 30.
  • the proportion of anionic surfactants in particular those previously listed as particularly advantageous anionic surfactants, which are sodium laureth sulfates and / or ammonium laureth sulfates, in the cosmetic cleaning preparation according to the invention 0, 1 wt .-% to 10 wt .-%, preferably 0.2 wt .-% to 6 wt .-% and particularly preferably 0.3 wt .-% to 4 wt .-%, based on the total weight of the cleaning preparation.
  • the cosmetic cleaning preparation according to the invention contains one or more amphoteric and / or zwitterionic surfactants.
  • amphoteric and / or zwitterionic surfactants are particularly used.
  • Disodium acylamphodipropionate disodium alkyl amphodiacetate, disodium
  • Cocoamphodiacetate sodium cocoamphomonoacetate
  • N-alkyl amino acids for example, aminopropylalkylglutamide, alkylaminopropionic acid, sodium alkylimidodipropionate and lauroamphocarboxyglycinate;
  • Betaines for example Coco Betaine, Cocoamidopropyl Betaine
  • Sultaines for example Lauryl Hydroxy Sultaine.
  • amphoteric and / or zwitterionic surfactants known under the INCI names include sodium cocoamphoacetate, disodium cocoamphodiacetate, sodium cocoamphopropionate, disodium cocoamphodipropionate, coco betaine, lauryl betaine and / or cocamidopropyl betaine. From the above group becomes
  • Cocamidopropyl betaine selected as the most preferred amphoteric and / or zwitterionic surfactant.
  • amphoteric and / or zwitterionic surfactants in particular those previously listed as particularly advantageous amphoteric and / or zwitterionic
  • Surfactants in the cosmetic cleaning preparation according to the invention 3 wt .-% to 20 Wt .-%, preferably 5 wt .-% to 17 wt .-% and particularly preferably 7.5 wt .-% to 13 wt .-%, based on the total weight of the cleaning preparation.
  • the weight ratio of the anionic surfactants to the amphoteric and / or zwitterionic surfactants is 1: 2 to 1: 20, preferably 1: 2.5 to 1: 15 .
  • the cleaning preparation with Polyquaternium-16 when using the surfactants in the defined weight ratios to a significantly lower turbidity.
  • the polyquaternium-16 polymers are characterized in that the ratio of the weight fraction of vinylpyrrolidone (VP) to the weight fraction of quaternized vinylimidazole (QVI) is 1: 0.5 to 1:50, preferably 1:10 to 1 : 30 based on the total weight of the polyquaternium-16 polymer.
  • the polyquaternium-16 polymers have a charge density of greater than or equal to 3 meq / g, preferably greater than 4 meq / g, at a pH of 7.
  • Polyquaternium-16 polymers have a middle
  • Cleaning preparation is preferably 0.5 wt .-% to 3 wt .-%, particularly preferably 0.8 wt .-% to 2.5 wt .-%, based on the total weight of the cosmetic
  • the cosmetic cleansing preparation according to the invention contains
  • R is a linear or branched Ce-Cie-alkyl radical or mixtures of different linear or branched Ce-Ciü-alkyl radicals;
  • R 1 is methyl, ethyl or mixtures thereof;
  • M + is a cation selected from the group consisting of alkali metals, NH 4 + and HNR 2 s + , where R 2 is selected from the group consisting of linear or branched alkyl radicals, CH 2 CH 2 OH and CH 2 CH (OH) CH 3 ;
  • X is an integer number in the range of 0-3;
  • y is an integer number in the range 0-10;
  • z is an integer number in the range 0-30;
  • amphoteric and / or zwitterionic surfactants preferably selected from the group Sodium Cocoamphoacetate, Disodium Cocoamphodiacetate, Sodium Cocoamphopropionate, Disodium Cocoamphodipropionate, Coco Betaine, Lauryl Betaine and / or Cocamidopropylbetaine; and
  • Polyquaternium-16 wherein the polyquaternium-16 polymers are characterized in that they have a charge density at a pH of 7 greater than or equal to 3 meq / g, preferably greater than 4 meq / g;
  • the weight ratio of all contained anionic surfactants to all contained amphoteric and / or zwitterionic surfactants 1: 2 to 1: 20, preferably 1: 2.5 to 1: 15.
  • Cosmetic cleaning preparation according to the invention in each case based on the
  • R is a linear or branched Ce-Cie-alkyl radical or mixtures of different linear or branched Cs-Cia-alkyl radicals;
  • R 1 is methyl, ethyl or mixtures thereof
  • M ' is a cation selected from the group consisting of alkali metals, NH 4 + and HNR + 2 is 3, wherein R 2 is selected from the group consisting of linear or branched alkyl groups, CH 2 CH 2 OH and CH 2 CH (OH) CH 3 ;
  • x is an integer number in the range of 0-3;
  • y is an integer number in the range 0-10;
  • z is an integer number in the range 0-30;
  • amphoteric and / or zwitterionic surfactants selected from the group Sodium Cocoamphoacetate, Disodium Cocoamphodiacetate, Sodium Cocoamphopropionate, Disodium cocoamphodipropionate, coco betaine, lauryl betaine and / or cocamidopropyl betaine; and
  • polyquaternium-16 from 0.5% to 3% by weight, preferably from 0.8% to 2.5% by weight of polyquaternium-16, wherein the polyquaternium-16 polymers are characterized in that
  • the ratio of the proportion by weight of the vinylpyrrolidone (VP) to the weight proportion of the quaternized vinylimidazole (QVI) is 1: 0.5 to 1:50, preferably 1:10 to 1: 30, based on the total weight of the polyquaternium-16 polymer;
  • the charge density at a pH of 7 is greater than or equal to 3 meq / g, preferably greater than 4 meq / g;
  • Particularly preferred cosmetic cleaning preparations according to the invention within the first embodiment contain, in each case based on the total weight,
  • amphoteric and / or zwitterionic surfactants selected from the group sodium cocoamphoacetate, disodium
  • Cocoamphodiacetate sodium cocoamphopropionate, disodium
  • Cocoamphodipropionates coco betaines, lauryl betaines and / or cocamidopropyl betaine
  • polyquaternium-16 from 0.8% to 2.5% by weight of polyquaternium-16, wherein the polyquaternium-16 polymers are characterized by
  • the ratio of the proportion by weight of the vinylpyrrolidone (VP) to the weight proportion of the quaternized vinylimidazole (QVI) is 1: 0.5 to 1:50, preferably 1: 10 to 1: 30, based on the total weight of the polyquaternium-16 polymer, the charge density at a pH of 7 is greater than or equal to 3 meq / g, preferably greater than 4 meq / g,
  • molecular weight less than 120,000 g / mol, preferably less than 50,000 g / mol;
  • the cosmetic cleaning preparation according to the invention additionally contains one or more nonionic surfactants.
  • nonionic surfactants are:
  • R is a linear or branched, saturated or unsaturated alkyl or
  • R ' ⁇ e is a hydrogen atom or a -
  • At least one of the groups R ' is a - (CH 2) n OH group, for example cocamide MEA / DEA / MI PA;
  • Alkyl polyglycosides such as lauryl glycoside, decyl glycoside and cocoglycoside. It is particularly advantageous if alkylpolyglycosides are present as nonionic surfactants.
  • the proportion of nonionic surfactants in particular the proportion of alkylpolyglycosides previously mentioned as particularly advantageous, in the inventive
  • Cleaning preparation 0.5 wt .-% to 4 wt .-%, based on the total weight of the preparation.
  • the cosmetic cleansing preparation according to the invention contains, in each case based on the total weight,
  • R is a linear or branched Ce-Cie-alkyl radical or mixtures of different linear or branched Ce-Cie-alkyl radicals
  • R 1 is methyl, ethyl or mixtures thereof
  • M + is a cation selected from the group consisting of alkali metals, NH 4 + and HNR + 2 is 3, wherein R 2 is selected from the group consisting of linear or branched alkyl groups, CH 2 CH 2 OH and CH 2 CH (OH) CH 3 ;
  • x is an integer number in the range of 0-3;
  • y is an integer number in the range 0-10;
  • z is an integer number in the range 0-30;
  • amphoteric and / or zwitterionic surfactants preferably selected from the group Sodium Cocoamphoacetate, Disodium Cocoamphodiacetate, Sodium Cocoamphopropionate, Disodium Cocoamphodipropionate, Coco Betaine, Lauryl Betaine and / or Cocamidopropylbetaine;
  • Polyquaternium-16 wherein the polyquaternium-16 polymers are characterized in that they have a charge density at a pH of 7 greater than or equal to 3 meq / g, preferably greater than 4 meq / g; and
  • the weight ratio of the anionic surfactants to the amphoteric and zwitterionic surfactants 1: 2 to 1: 20, preferably 1: 2.5 to 1: 15.
  • R is a linear or branched Ce-Cie-alkyl radical or mixtures of different linear or branched Ce-Cie-alkyl radicals;
  • R 1 is methyl, ethyl or mixtures thereof
  • M ' is a cation selected from the group consisting of alkali metals, NH 4 + and HNR + 2 is 3, wherein R 2 is selected from the group consisting of linear or branched alkyl groups, CH 2 CH 2 OH and CH 2 CH (OH) CH 3 ;
  • x is an integer number in the range of 0-3;
  • y is an integer number in the range 0-10;
  • z is an integer number in the range 0-30;
  • amphoteric and / or zwitterionic surfactants selected from the group sodium
  • polyquaternium-16 from 0.5% to 3% by weight, preferably from 0.8% to 2.5% by weight, polyquaternium-16, wherein the polyquaternium-16 polymers are characterized in that
  • the ratio of the weight proportion of the vinylpyrrolidone (VP) to the weight proportion of the quaternized vinylimidazole (QVI) is 1: 0.5 to 1:50, preferably 1:10 to 1: 30, based on the total weight of the polyquaternium-16 polymer;
  • the charge density at a pH of 7 is greater than or equal to 3 meq / g
  • molecular weight less than 120,000 g / mol, preferably less than 50,000 g / mol;
  • R is a linear or branched, saturated or unsaturated alkyl or alkenyl radical having 8 to 24 carbon atoms
  • R ' ⁇ e is a hydrogen atom or a - (CH 2) n OH group, in which n can assume the numbers 2 or 3, with the proviso that at least one of the groups R 'is a - (CH 2) n OH group;
  • the weight ratio of all contained anionic surfactants to all contained amphoteric and / or zwitterionic surfactants 1: 2 to 1: 20, preferably 1: 2.5 to 1: 15, wherein it is preferred if in addition to the said anionic
  • Surfactants a) and the amphoteric and / or zwitterionic surfactants b) contain no further anionic surfactants and no further amphoteric and / or zwitterionic surfactants.
  • Particularly preferred cosmetic cleaning preparations according to the invention within the second embodiment contain, in each case based on the total weight,
  • amphoteric and / or zwitterionic surfactants selected from the group sodium cocoamphoacetate, disodium
  • Cocoamphodiacetate sodium cocoamphopropionate, disodium
  • Cocoamphodipropionates coco betaines, lauryl betaines and / or cocamidopropyl betaine; c) from 0.8% to 2.5% by weight of polyquaternium-16, wherein the polyquaternium-16 polymers are characterized by
  • R is a linear or branched, saturated or unsaturated alkyl or alkenyl radical having 8 to 24 carbon atoms
  • R ' ⁇ e represents a hydrogen atom or a - (CH 2) n OH group, in which n can take the numbers 2 or 3, with the proviso that at least one of the groups R 'is a - (CH 2) n OH group
  • the cosmetic cleansing preparation according to the invention contains, in each case based on the total weight,
  • R is a linear or branched Ce-C-m-alkyl radical or mixtures of different linear or branched Cs-Cis-alkyl radicals
  • R 1 is methyl, ethyl or mixtures thereof
  • M ' is a cation selected from the group consisting of alkali metals, NHV and HNR 2 3 +, wherein R 2 is selected from the group consisting of linear or branched alkyl groups, CH 2 CH 2 OH and CH 2 CH (OH) CH 3 ;
  • x is an integer number in the range of 0-3;
  • y is an integer number in the range 0-10;
  • z is an integer number in the range 0-30;
  • amphoteric and / or zwitterionic surfactants selected from the group sodium cocoamphoacetate, disodium Cocoamphodiacetate, sodium cocoamphopropionate, disodium
  • Cocoamphodipropionates coco betaines, lauryl betaines and / or cocamidopropyl betaine; c) from 0.8% to 2.5% by weight of polyquaternium-16, wherein the polyquaternium-16 polymers are characterized by
  • the ratio of the proportion by weight of the vinylpyrrolidone (VP) to the weight proportion of the quaternized vinylimidazole (QVI) is 1: 0.5 to 1:50, preferably 1:10 to 1: 30, based on the total weight of the polyquaternium-16 polymer;
  • the charge density at a pH of 7 is greater than or equal to 3 meq / g, preferably greater than 4 meq / g;
  • amphoteric and / or zwitterionic surfactants selected from the group sodium cocoamphoacetate, disodium
  • Cocoamphodiacetate sodium cocoamphopropionate, disodium
  • Cocoamphodipropionates coco betaines, lauryl betaines and / or cocamidopropyl betaine; c) from 0.8% to 2.5% by weight of polyquaternium-16, wherein the polyquaternium-16 polymers are characterized by
  • the ratio of the weight proportion of the vinylpyrrolidone (VP) to the weight proportion of the quaternized vinylimidazole (QVI) is 1: 0.5 to 1:50, preferably 1:10 to 1: 30, based on the total weight of the polyquaternium-16 polymer;
  • the charge density at a pH of 7 is greater than or equal to 3 meq / g, preferably greater than 4 meq / g;
  • molecular weight less than 120,000 g / mol, preferably less than 50,000 g / mol;
  • R is a linear or branched, saturated or unsaturated alkyl or alkenyl radical having 8 to 24 carbon atoms
  • R 'e is a hydrogen atom or a - (CH 2 ) n OH group in which n can assume the numbers 2 or 3, with the proviso that at least one of R 'is a - (CH 2 ) n OH group;
  • the cosmetic cleaning agent according to the invention contains water as cosmetic carrier in a proportion of 50% by weight to 90% by weight, preferably 75% by weight to 85% by weight, based on the total weight of the cosmetic preparation ,
  • other polymers can optionally be used, which can be selected from the group of polysaccharides or their derivatives, for. B. hydroxypropylmethylcellulose and / or advantageously from the group of polyacrylates, preferably a polyacrylate from the group of the so-called carbopols, for example Carbopols types 980, 981, 1382, 2984, 5984, each individually or in combination.
  • carbopols for example Carbopols types 980, 981, 1382, 2984, 5984, each individually or in combination.
  • thickeners selected from the group PEG-150 / stearyl alcohol / SMDI copolymer, PEG-150 distearate, PEG-200 glyceryl tallowate, PEG-200 hydrogenated glyceryl palmate, PEG-40 hydrogenated castor oil and / or PEG -90 glyceryl isostearates.
  • the inventive thickeners selected from the group PEG-150 / stearyl alcohol / SMDI copolymer, PEG-150 distearate, PEG-200 glyceryl tallowate, PEG-200 hydrogenated glyceryl palmate, PEG-40 hydrogenated castor oil and / or PEG -90 glyceryl isostearates.
  • sodium chloride is contained in a proportion of 0.5% by weight to 2.5% by weight, preferably 0.8% by weight to 2.0% by weight, based on the total weight of the preparation.
  • Citric acid and / or salts of citric acid are present at a level of from 0.3% to 2.0%, preferably from 0.5% to 1.5% by weight, based on the total weight of the Preparation included.
  • the weight ratio of sodium chloride to citric acid and / or salts of citric acid is 2: 1 to 1: 2, preferably 1, 8: 1 to 1, 4: 1.
  • thickener PEG-200 Hydrogenated Glyceryl Palmate, PEG-40 Hydrogenated Castor Oil and / or PEG-90 glyceryl isostearates are included.
  • the content of the thickeners PEG-200 hydrogenated glyceryl palmitate, PEG-40 hydrogenated castor oil and / or PEG-90 glyceryl isostearate used preferably 0.1 to 1, 5 wt .-%, preferably 0.2 Wt .-% to 1, 3 wt .-%, particularly preferably 0.5 wt .-% to 1 wt .-%, based on the total weight of the preparation.
  • the preservatives commonly used in cosmetics can be used. These include, for example, parabens such as methylparaben, propylparaben, ethylparaben and butylparaben.
  • parabens such as methylparaben, propylparaben, ethylparaben and butylparaben.
  • acid-based preservatives which are used in the food industry. These include, for example, benzoic acid and / or salicylic acid and / or their salts.
  • Cleaning preparations having a pH of less than pH 6 are preferred according to the invention, cleaning preparations having a pH of from 4 to 4.8 being particularly preferred according to the invention.
  • the adjustment of the pH can be carried out in the manner customary in the cosmetic industry. However, it is preferable to use citric acid and sodium hydroxide to adjust the required pH.
  • the preparations according to the invention may contain, inter alia, opacifiers. These are water-insoluble, mostly microparticulate substances that reflect the light particularly well and give the preparation a milky or cloudy appearance.
  • Opacifiers according to the invention are styrene / acrylates copolymer or glycol distearate, glyceryl stearate, PEG-3 distearate.
  • the average molecular weight of Polyquaternium-16 polymers can be determined according to the invention via light scattering.
  • the cosmetic cleansing preparations according to the invention may further contain cosmetic auxiliaries and active ingredients, as are commonly used in such preparations, for. B.
  • the bacterium C. jeikeium (DSM 7171) was streaked out of an EN 12353 cryotube on an agar plate and incubated at 30 ° C for 48 hours. From the grown bacteria, a second passage was prepared as liquid culture in AC medium (37 g brain-heart boullion, 5 g glucose, 1 mL polysorbate 80 / Tween®80 made up to 1 L with H 2 O). The liquid culture was, after an optical density determination (Eppendorf BioPhotometer at 600 nm), adjusted to a cell count of 10 5 and 1: 8 with thickened medium (AC- Medium + 0.2% agar). This bacterial suspension was then used for the test.
  • AC medium 37 g brain-heart boullion, 5 g glucose, 1 mL polysorbate 80 / Tween®80 made up to 1 L with H 2 O.
  • the liquid culture was, after an optical density determination (Eppendorf BioPhotometer at 600 nm), adjusted to a cell count of 10 5 and 1: 8 with
  • the pigskin was trimmed to a size of 9.5 cm x 3.5 cm.
  • the bacteria were filled with a rinse solution (rinse solution: 12.5 g Na 2 HP0 4 x 2H 2 0, 0.64 g KH 2 P0 4 , 1 g Triton X-100 to 1 L with H 2 O) (30 seconds, 3 times 1 ml).
  • 200 ⁇ l of the rinsed solutions are pipetted into 800 ⁇ l neutralization medium (1 g peptone, 8.5 g sodium chloride, 30 g Tween® 80, 30 g saponin, 1 g L-histidine, 3 g lecithin, 5 g sodium thiosulfate made up to 1 L with H 2 O).
  • the reduction factor for the cosmetic cleaning preparations investigated is obtained by dividing the germ count of the reference measurement by the germ count of the respective measurement of the example formulations.
  • example formulation Bsp.3 was investigated in an in vivo study compared to Baktolin® pure skin wash (Bode Chemie). 12 people participated in the study. The study was conducted in the Armachsel region.
  • the participants In preparation for the study, the participants have applied no cosmetic product in the armpit for 5 days. 2-3 days before the study, the participants have shaved the Axel.
  • the example formulation Bsp.3 was examined on one armpit and Baktolin® pure skin wash on the other armpit.
  • the respective skin region with a Teflon ring (2 cm diameter) with 1 ml of 0.067 molar phosphate buffer (pH 7.9, containing 0, 1 wt .-% Triton X-100) rinsed for 1 minute, during which process with a Plastic part was striped over the skin area.
  • the washing solution was collected as reference measurement at time t0.
  • the participants then washed with a cloth with 40 ml of water and 4 ml of test product (Ex.3 or Baktolin® pure skin wash) the skin region.
  • test products were then washed off with a further cloth with 80 ml of water for a period of 30 seconds.
  • the respective skin region was rinsed again within the teflon ring with 1 ml of 0.067 molar phosphate buffer (pH 7.9, containing 0.1% by weight of Triton X-100) for 1 minute, during this process was striped over the skin region with a plastic part.
  • the washing solution at time t1 and t2 was respectively collected.
  • CFU Coldy Forming Units
  • Example 3 a significantly more effective antimicrobial efficacy than baktolin.
  • the improved deposition of Polyquaternium-16 will provide effective antimicrobial efficacy achieved against the bacteria occurring in the armpit.
  • Corynebacterium jeikeium or Staphylococcus epidermidis usually occur in axillary regions.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne une composition nettoyante cosmétique contenant des polymères polyquaternium-16, des tensioactifs anioniques et des tensioactifs amphotères et/ou zwitterioniques. Ladite composition nettoyante permet de déposer de manière efficace des polymères polyquaternium-16 à action antimicrobienne sur la peau.
PCT/EP2018/056974 2017-03-21 2018-03-20 Composition nettoyante moussante contenant des polymères polyquaternium-16 Ceased WO2018172332A1 (fr)

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DE102017204680.5A DE102017204680A1 (de) 2017-03-21 2017-03-21 Schäumende Reinigungszubereitung enthaltend Polyquaternium-16 Polymere
DE102017204680.5 2017-03-21

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Cited By (2)

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CN110339120A (zh) * 2019-08-21 2019-10-18 福建柚之源生物科技有限公司 一种洗发水及其制备方法
CN113073015A (zh) * 2021-02-25 2021-07-06 郑州百瑞动物药业有限公司 一种宠物用杀菌除臭洗衣液及其制备方法

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Publication number Priority date Publication date Assignee Title
WO1998050007A1 (fr) 1997-05-05 1998-11-12 The Procter & Gamble Company Compositions de shampooing donnant du corps aux cheveux et contenant des polymeres de coiffage cationique
US20040136940A1 (en) * 2002-10-31 2004-07-15 Virginia Lazarowitz Cleaner compositions
WO2016012417A2 (fr) 2014-07-24 2016-01-28 Beiersdorf Ag Préparations pour déodorants, contenant des polymères polyquaternium

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WO1998050007A1 (fr) 1997-05-05 1998-11-12 The Procter & Gamble Company Compositions de shampooing donnant du corps aux cheveux et contenant des polymeres de coiffage cationique
US20040136940A1 (en) * 2002-10-31 2004-07-15 Virginia Lazarowitz Cleaner compositions
WO2016012417A2 (fr) 2014-07-24 2016-01-28 Beiersdorf Ag Préparations pour déodorants, contenant des polymères polyquaternium

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110339120A (zh) * 2019-08-21 2019-10-18 福建柚之源生物科技有限公司 一种洗发水及其制备方法
CN113073015A (zh) * 2021-02-25 2021-07-06 郑州百瑞动物药业有限公司 一种宠物用杀菌除臭洗衣液及其制备方法

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