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WO2018025162A1 - Emballage pour produits à préparation extemporanés, en particulier des produits médicaux, pharmaceutiques, cosmétiques ou similaires - Google Patents

Emballage pour produits à préparation extemporanés, en particulier des produits médicaux, pharmaceutiques, cosmétiques ou similaires Download PDF

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Publication number
WO2018025162A1
WO2018025162A1 PCT/IB2017/054661 IB2017054661W WO2018025162A1 WO 2018025162 A1 WO2018025162 A1 WO 2018025162A1 IB 2017054661 W IB2017054661 W IB 2017054661W WO 2018025162 A1 WO2018025162 A1 WO 2018025162A1
Authority
WO
WIPO (PCT)
Prior art keywords
packaging
substance
tank
fact
container
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2017/054661
Other languages
English (en)
Inventor
Enrico SALVARANI
Francesco Becchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lameplast SRL
Original Assignee
Lameplast SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lameplast SRL filed Critical Lameplast SRL
Priority to CA3032109A priority Critical patent/CA3032109A1/fr
Priority to US16/321,026 priority patent/US20190177057A1/en
Priority to EP17758629.4A priority patent/EP3490902A1/fr
Publication of WO2018025162A1 publication Critical patent/WO2018025162A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/24—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes
    • B65D51/28—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials
    • B65D51/2807—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container
    • B65D51/2814—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container the additional article or materials being released by piercing, cutting or tearing an element enclosing it
    • B65D51/2828—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container the additional article or materials being released by piercing, cutting or tearing an element enclosing it said element being a film or a foil
    • B65D51/2835—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container the additional article or materials being released by piercing, cutting or tearing an element enclosing it said element being a film or a foil ruptured by a sharp element, e.g. a cutter or a piercer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3205—Separate rigid or semi-rigid containers joined to each other at their external surfaces

Definitions

  • the present invention relates to a packaging for extemporaneous preparation products, particularly medicinal, pharmaceutical, cosmetic products or the like.
  • extemporaneous preparation products i.e. products consisting of the solution or the mixture of at least two different substances, of which one is e.g. in the liquid state and the other in the powdery state, which are kept separate from each other until the time of use.
  • a packaging that essentially consists of a container which is closed at the bottom and extends superiorly into a neck at the top of which a mouth is defined; inside the container there is a first substance, generally in the liquid state.
  • a tank of a second substance which consists of a cylindrical hollow body, inferiorly closed by a frangible bottom and superiorly open; the bottom of the tank, until it remains intact, separates the second substance from the first one.
  • a cutting element which consists of a tubular body, the lower ending part of which is sectioned according to a oblique plane or shaped like a flute spout, and the upper ending part of which extends beyond the upper opening of the tank.
  • the cutting element is axially sliding with respect to the tank between a noninterference configuration, in which it is placed above the intact bottom of the tank itself, and a cutting configuration in which, pushed towards the bottom of the tank itself, it cuts the latter along the perimeter edge by placing the tank, thus opened, in communication with the container.
  • Known packaging is also provided with a cover cap which is associated with the neck of the container; the lower edge of the cap is temporarily bound, along a breaking line, to a sealing ring bound to the neck of the container and provided with a weakened axial line at which it opens.
  • the cap is pushed towards the neck of the container thus causing the cutting element to slide inside the tank until the bottom of the latter is cut off; the second substance then pours from the tank to the container, within which it blends with the first substance thus forming the product.
  • the vapors released by the liquid substance present in the container permeate, in part, inside the tank where there is generally a powdery, often hygroscopic, substance.
  • the powdery substance absorbs the vapors released by the liquid one impregnating with them and thickening into agglomerates.
  • the tank When, at the time of preparing the product, the tank is opened and placed in communication with the container, the agglomerates that are formed tend to remain inside the tank and, even when poured into the container, they hardly dissolve and disperse completely into the liquid substance.
  • composition of the product so formed does not correspond to that for which it is intended; in the event of the product being a drug or a medicinal product, this causes an indeterminable alteration in the content of its active ingredients as well as in the dosage established for it and, consequently, a disadvantageous modification of the therapy studied for a patient.
  • bottles are known such as those disclosed in the documents EP 1 186 548 and EP 1 858 774, wherein the container containing the second substance defines an insulating interspace to hinder the passage of the vapors released by the liquid substance.
  • the main aim of the present invention is to provide a packaging for extemporaneous preparation products, particularly medicinal, pharmaceutical, cosmetic products or the like, which allows to effectively keep the substances composing the product perfectly separated and isolated from one another until the time of product preparation.
  • One object of the present invention is to provide a packaging which permits, in particular, to prevent the absorption by a substance, generally the powdery and hygroscopic one, of the vapors released by another, generally liquid, substance, and hence the formation of unwanted thickenings and agglomerates.
  • Another object of the present invention is to provide a packaging that can be used and opened in a simple, practical and easy manner by the users, without requiring any special effort.
  • Not the last object of the present invention is to provide a packaging with reduced costs and production times, that is easy to assemble and which allows limiting the quantities of construction materials used for its production.
  • Another object of the present invention is to provide a packaging for extemporaneous preparation products, particularly medicinal, pharmaceutical, cosmetic products or the like, which allows to overcome the aforementioned drawbacks of the prior art within the ambit of a simple, rational, easy, efficient to use and cost-effective solution.
  • Figure 1 is an exploded and partially broken view of the packaging according to the invention
  • Figure 2 is an axonometric and broken view of the packaging according to the invention in an idle configuration
  • Figure 3 is an axonometric and partially broken view of the packaging according to the invention in a breakthrough configuration
  • Figure 4 is an axonometric view of the packaging according to the invention in the dispensing phase of the product.
  • reference numeral 1 globally indicates a packaging for extemporaneous preparation products, particularly medicinal, pharmaceutical, cosmetic products or the like.
  • the packaging 1 comprises at least one container 2, 3, at least in part internally hollow and containing a first substance SI, the container 2, 3 comprising a container body 2 and a mouth 3 formed on the container body 2.
  • the container body 2 e.g., is made of flexible and deformable plastic to push the first substance SI to exit through the mouth 3.
  • the packaging 1 also comprises at least one tank 4, 5, at least in part internally hollow and containing a second substance S2 mixable with the first substance
  • the first substance SI, the second substance S2 and the product P obtained from mixing the two are fluid products.
  • fluid products are not only meant liquid products but also viscous products, e.g. in the paste and gel state, and powdery products, in particular very fine powders with high smoothness.
  • the first substance SI for example, is present in the liquid state while the second substance S2 is present in the powdery state.
  • the tank 4, 5 is associated with the container 2, 3 and comprises:
  • At least one tank body 4 substantially tubular that extends between a first ending part 4a, arranged towards the inside of the container body 2 through the mouth 3, and a second ending part 4b, arranged on the opposite side of the first ending part 4a;
  • frangible separation partition 5 arranged inside the tank body 4 between the first ending part 4a and the second ending part 4b, in which the frangible separation partition 5 divides the tank body 4 into a first sector 4c, which extends between the first ending part 4a and the frangible separation partition 5, and into a second sector 4d, which extends between the frangible separation partition 5 and the second ending part 4b.
  • the tank body 4 and the frangible separation partition 5 are made in a single monolithic body and joined along a weakened section connection line 6.
  • the weakened section connection line 6 can be broken, thus allowing the separation of the frangible separation partition 5 from the tank body 4.
  • the tank 4, 5 is joinable to the container 2, 3 by means of first interlocking means 7.
  • the packaging 1 also comprises at least one closure body 8 which is associated with the first ending part 4a.
  • closure body 8 closes the first ending part 4a to obtain an internal volume in the first sector 4c of the tank 4, 5 that contains the second substance S2 and which is temporarily separated from the internal volume of the container 2, 3 which contains, on the contrary, the first substance SI.
  • the closure body 8 has at least one barrier layer.
  • barrier layer is meant a layer of the closure body 8 which is made of a barrier material, i.e. a material which is resistant to the crossing of agents such as oxygen, gas and/or water vapor.
  • Barrier materials can be of both metallic and plastic type.
  • barrier materials are the following:
  • EVOH ethylene vinyl alcohol
  • LDPE low density polyethylene
  • HDPE high density polyethylene
  • LLDPE linear low density polyethylene
  • the barrier layer in the closure body 8 is made of aluminum and the closure body 8 consists, e.g. of a polyethylene and aluminum poly-laminate sheet (PE/ALU).
  • PE/ALU polyethylene and aluminum poly-laminate sheet
  • the joining of the closure body 8 at the first ending part 4a occurs, for example, by induction sealing.
  • the packaging 1 also comprises at least one perforating body 9 fitted inside the second sector 4d in a sliding manner along a direction of sliding A.
  • the perforating body 9 is movable between an idle configuration spaced apart from the frangible separation partition 5 and a breakthrough configuration in which the frangible separation partition 5 and the closure body 8 are broken through by the perforating body 9 to allow the mixing of the first substance SI and of the second substance S2 and the formation of the product P.
  • breakthrough of the closure body 8 can be meant indifferently one of the following circumstances: the closure body 8, under the thrust of the perforating body 9, detaches at least partially from the first ending part 4a without breaking;
  • the breakthrough of the frangible separation partition 5 and the closure body 8 is intended to place the internal volume of the first sector 4c, initially closed and isolated when the perforating body 9 is in the idle configuration, in communication with the internal volume of the container 2, 3, when the perforating body 9 passes to the breakthrough configuration.
  • the perforating body 9 comprises:
  • a first extremal stretch 9a turned towards the inside of the container body 2 and having an edge 10 at least partially inclined relative to the direction of sliding A which facilitates the breakthrough of the frangible separation partition 5 and of the closure body 8;
  • the perforating body 9 has a substantially tubular shape and the second extremal stretch 9b has a transit opening 11 for the outflow of the product P.
  • the second extremal stretch 9b is a dropper, i.e. it is provided with a very tight transit opening 11 having a predetermined diameter depending on the rheological properties of the product P, so as to permit the crossing of product P only in the form of drops.
  • the packaging 1 also comprises at least a push cap 12 arranged at least partially around the perforating body 9, the push cap 12 being operable to push the perforating body 9 from the idle configuration to the breakthrough configuration.
  • the push cap 12 is screwable on the outer surface of the tank body 4.
  • the push cap 12 has an inner thread 13 while the tank body 4 has an outer thread 14 onto which the inner thread 13 of the push cap 12 can be screwed.
  • the activation of the push cap 12 occurs therefore by screwing-in and not by simple pressure, which facilitates the operator thus reducing the force that the latter has to apply for the opening of the packaging 1.
  • the push cap 12 comprises a blockage internal portion 15 adapted to close the transit opening 11 formed on the second extremal stretch 9b, in the breakthrough configuration the push cap 12 being removable to release the transit opening 11.
  • the packaging 1 also comprises a closing plug 16, 17 having:
  • first portion 16 substantially tubular, which is associated with at least one of the container 2, 3 and the tank 4, 5;
  • the first portion 16 and the second portion 17 are implemented in a single monolithic body and the frangible joining means 18 comprise a weakened section joining line.
  • the screwing-in of the second portion 17 or push cap 12 on the tank 4, 5 causes the breakage of the frangible joining means 18, which performs the function of a tamper-evident element since it indicates that the packaging 1 has been opened beforehand.
  • the closing plug 16, 17 is joinable to the tank 4, 5 by means of second interlocking means 19.
  • the closing plug 16, 17 is devoid of openings and, when fitted onto the tank 4, 5, it protects the tank body 4 and the perforating body 9 (in particular the second extremal stretch 9b which performs the function of a dropper) from the external environment, preventing the passage of liquids, powders and other contaminants.
  • the operation of the packaging 1 is as follows.
  • the packaging 1 is manufactured as five separate components (Figure 1): container 2, 3, tank 4, 5, closure body 8, perforating body 9 and closing plug 16, 17, which integrates the push cap 12.
  • the container 2, 3 is filled with the first substance SI and the tank 4, 5 is filled with the second substance S2, which is poured through the first ending part 4a, then closed by means of the closure body 8.
  • the packaging 1 is assembled by interlocking the tank 4, 5 into the mouth 3, by inserting the perforating body 9 into the second sector of the tank 4, 5 and finally fitting the closing plug 16, 17 around the perforating body 9 and the tank 4, 5 until the first portion 16 is interlocked with the tank 4, 5 ( Figure 2).
  • the push cap 12 is screwed onto the tank 4, 5, causing the breaking of the frangible joining means 18 and the displacement of the perforating body 9 from the idle configuration to the breakthrough configuration.
  • the second substance S2 can then pour into the container 2, 3 to form the product P ( Figure 3).
  • the present packaging allows keeping the substances making up the product separate and perfectly isolated from one another until the time the product has to be prepared.
  • a closure body having at least one barrier layer allows in fact isolating perfectly the second substance from the first one, thus avoiding that the second substance absorbs the vapors released from the first substance, thus preventing the formation of thickenings and agglomerates and ensuring the complete dissolution of one into the other.
  • the packaging according to the invention thus ensures the preparation of a product with desired composition, in the particular case of medicinal or pharmaceutical products, with a predetermined content of active ingredients, thus permitting compliance with the established dosage for a patient's therapy.
  • the packaging according to the invention is practical and easy to use by the users and does not require any particular effort to be applied.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Package Specialized In Special Use (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un emballage (1) pour des produits à préparation extemporanée, en particulier de produits médicaux, pharmaceutiques, cosmétiques ou similaires, comprenant : un récipient (2, 3) qui contient une première substance (S1) ; un réservoir (4, 5) qui contient une deuxième substance (S2) et comprenant : un corps de réservoir (4) ; une cloison de séparation cassante (5) ; un corps de fermeture (8) qui comporte au moins une couche barrière et qui est associé au corps de réservoir (4) ; et un corps de perforation (9) monté coulissant à l'intérieur du corps de réservoir (4) et pouvant être déplacé entre une configuration de repos éloignée de la cloison de séparation cassante (5) et une configuration de percée dans laquelle la cloison de séparation cassante (5) et le corps de fermeture (8) sont transpercés par le corps de perforation (9) afin de permettre le mélange de la première substance (S1) et de la deuxième substance (S2) et la formation d'un produit (P).
PCT/IB2017/054661 2016-08-01 2017-07-31 Emballage pour produits à préparation extemporanés, en particulier des produits médicaux, pharmaceutiques, cosmétiques ou similaires Ceased WO2018025162A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA3032109A CA3032109A1 (fr) 2016-08-01 2017-07-31 Emballage pour produits a preparation extemporanes, en particulier des produits medicaux, pharmaceutiques, cosmetiques ou similaires
US16/321,026 US20190177057A1 (en) 2016-08-01 2017-07-31 Packaging for extemporaneous preparation products, particularly medicinal, pharmaceutical, cosmetic products or the like
EP17758629.4A EP3490902A1 (fr) 2016-08-01 2017-07-31 Emballage pour produits à préparation extemporanés, en particulier des produits médicaux, pharmaceutiques, cosmétiques ou similaires

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT102016000080494 2016-08-01
IT102016000080494A IT201600080494A1 (it) 2016-08-01 2016-08-01 Confezione per prodotti a preparazione estemporanea, particolarmente medicinali, farmaceutici, cosmetici o simili

Publications (1)

Publication Number Publication Date
WO2018025162A1 true WO2018025162A1 (fr) 2018-02-08

Family

ID=58159238

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2017/054661 Ceased WO2018025162A1 (fr) 2016-08-01 2017-07-31 Emballage pour produits à préparation extemporanés, en particulier des produits médicaux, pharmaceutiques, cosmétiques ou similaires

Country Status (5)

Country Link
US (1) US20190177057A1 (fr)
EP (1) EP3490902A1 (fr)
CA (1) CA3032109A1 (fr)
IT (1) IT201600080494A1 (fr)
WO (1) WO2018025162A1 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0561322A1 (fr) * 1992-03-19 1993-09-22 Lameplast S.R.L. Flacon compte-gouttes pour deux produits devant être mélangés avant usage

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3802604A (en) * 1972-02-28 1974-04-09 Oreal Device for storing two products separately and dispensing them simultaneously
ES2128220B1 (es) * 1995-12-04 1999-12-16 Cusi Lab Envase farmaceutico de dos sustancias separadas, con dispositivo de mezcla, aplicacion dosificada y su proceso de montaje.
US6513650B2 (en) * 1997-10-14 2003-02-04 Biogaia Ab Two-compartment container
IT1316941B1 (it) * 2000-10-25 2003-05-13 Lameplast Spa Flacone per prodotti estemporanei bicompenenti.
ATE328813T1 (de) * 2004-03-11 2006-06-15 3M Espe Ag Kapsel zur lagerung, mischung und ausgabe von materialien
ITMO20050058A1 (it) * 2005-03-15 2006-09-16 Lameplast Spa Confezione per prodotti a preparazione estemporanea, particolarmente medicinali, farmaceutici, cosmetici o simili.
FR2922867B1 (fr) * 2007-10-31 2009-12-25 Idecap Dispositif doseur adaptable sur un contenant

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0561322A1 (fr) * 1992-03-19 1993-09-22 Lameplast S.R.L. Flacon compte-gouttes pour deux produits devant être mélangés avant usage

Also Published As

Publication number Publication date
US20190177057A1 (en) 2019-06-13
IT201600080494A1 (it) 2018-02-01
CA3032109A1 (fr) 2018-02-08
EP3490902A1 (fr) 2019-06-05

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