[go: up one dir, main page]

WO2018065190A1 - Liquide désinfectant pour toilette personnelle - Google Patents

Liquide désinfectant pour toilette personnelle Download PDF

Info

Publication number
WO2018065190A1
WO2018065190A1 PCT/EP2017/073390 EP2017073390W WO2018065190A1 WO 2018065190 A1 WO2018065190 A1 WO 2018065190A1 EP 2017073390 W EP2017073390 W EP 2017073390W WO 2018065190 A1 WO2018065190 A1 WO 2018065190A1
Authority
WO
WIPO (PCT)
Prior art keywords
antimicrobial composition
composition
quaternary ammonium
antimicrobial
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2017/073390
Other languages
English (en)
Inventor
Ajit Manohar AGARKHED
Mohini Anand Bapat
Nikita TOMAR
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Unilever NV
Conopco Inc
Original Assignee
Unilever NV
Conopco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever NV, Conopco Inc filed Critical Unilever NV
Priority to CN201780062189.9A priority Critical patent/CN109803532A/zh
Priority to MX2019003774A priority patent/MX2019003774A/es
Priority to BR112019005645-9A priority patent/BR112019005645B1/pt
Publication of WO2018065190A1 publication Critical patent/WO2018065190A1/fr
Priority to ZA2019/01673A priority patent/ZA201901673B/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/12—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A61K8/416—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18

Definitions

  • the present invention relates to an antimicrobial composition.
  • the present invention more particularly relates to an antimicrobial composition suitable as a personal wash disinfectant liquid.
  • the skin is the biggest organ of our body and it acts as a protective layers against bacteria and other harmful germs. Everyday our body is assaulted by harmful chemicals, dirt and grime. Washing and bathing are the most important ways of maintain good health and protecting oneself from infections, illnesses and ailments. Staying clean at all times helps to keep germs away and prevent major diseases that they may cause. Therefore, it is of utmost importance and highly desirable that the daily bathing routine is supplemented by a regime that leaves the skin free of infection causing agents such as microbes.
  • WO1995031958 discloses that certain combinations of substituted imidazoline- based amphoterics and quaternary ammonium compounds show markedly reduced irritation profile in addition to providing excellent cleaning detergency.
  • the object of the present invention is therefore to provide for a synergistic antimicrobial composition that provides the desired antimicrobial action even after diluting with water and which provides a visual cue of change in colour on dilution.
  • First aspect of the present invention provides an antimicrobial composition
  • an antimicrobial composition comprising: a. 0.01 to 15 wt% of a first quaternary ammonium composition comprising didecyl dimethyl ammonium chloride or a derivative thereof; and
  • BKC benzalkonium chloride
  • the antimicrobial composition comprises at most 10% wt of C2 to C3 monohydric alcohols
  • the additive concentration of non-ionic and anionic surfactant in the antimicrobial composition is less than 5 wt% based on the weight of the antimicrobial composition
  • the antimicrobial compostion further comprises a pH indicator.
  • Another aspect of the present invention provides for 0.01 to 15 wt% of a first quaternary ammonium composition comprising didecyl dimethyl ammonium chloride or a derivative thereof; and 0.01 to 15 wt% of a second quaternary ammonium composition comprising benzalkonium chloride (BKC) or a derivative thereof; and a pH indicator as a disinfectant for use in personal hygiene.
  • a first quaternary ammonium composition comprising didecyl dimethyl ammonium chloride or a derivative thereof
  • BKC benzalkonium chloride
  • Another aspect of the present invention provides a method of personal wash, the method comprising steps of: a. diluting the antimicrobial composition according to the first aspect to at most to 5000 times to obtain a diluted antimicrobial composition, and
  • step b washing the surface of skin with the antimicrobial diluted composition resulting from step a.
  • Another aspect of the present invention provides a disinfectant kit for personal wash, the kit comprising: a. an antimicrobial composition according to the first aspect,
  • Another aspect of the present invention provides a method of manufacture of the composition according to the first aspect, the method comprising: a. adding the first quaternary ammonium composition and the second quaternary ammonium composition; and
  • any feature of one aspect of the present invention may be utilised in any other aspect of the invention.
  • the word “comprising” is intended to mean “including”. In other words, the listed steps or options need not be exhaustive. It is noted that the examples given in the description below are intended to clarify the invention and are not intended to limit the invention to those examples per se. Similarly, all percentages are weight/weight percentages unless otherwise indicated. Except in the operating and comparative examples, or where otherwise explicitly indicated, all numbers in this description indicating amounts of material or conditions of reaction, physical properties of materials and/or use are to be understood as modified by the word “about”. Numerical ranges expressed in the format “from x to y” are understood to include x and y. When for a specific feature multiple preferred ranges are described in the format “from x to y”, it is understood that all ranges combining the different endpoints are also contemplated.
  • the present invention provides an antimicrobial composition comprising: a. 0.01 to 15 wt% of a first quaternary ammonium composition comprising didecyl dimethyl ammonium chloride or a derivative thereof; and b. 0.01 to 15 wt% of a second quaternary ammonium composition comprising benzalkonium chloride (BKC) or a derivative thereof;
  • BKC benzalkonium chloride
  • the antimicrobial composition comprises at most 10% wt of C2 to C3 monohydric alcohols
  • the additive concentration of non-ionic and anionic surfactant in the antimicrobial composition is less than 5 wt% based on the weight of the antimicrobial composition
  • Quaternary Ammonium Composition The disclosed embodiments comprise a quaternary ammonium composition comprising a quaternary ammonium compound or other compound having the same effects. Quaternary ammonium compounds are ammonium compounds in which all four of the ammonium's hydrogen atoms have been replaced by organic groups.
  • the quaternary ammonium compounds of the present disclosure have the following basic structure: wherein R1 , R2, R3, and R4 are organic substituent groups that provide the quaternary ammonium compound with antimicrobial properties and X is any anion that makes the compound sufficiently water soluble to allow the compound to form an antimicrobial solution. With reference to this general formula, R1 , R2, R3, and R4 are typically independently selected from the group consisting of all alkyl groups and aryl groups.
  • the antimicrobial activity of quaternary ammonium compounds may be related to their ability to disrupt the cell membranes of microbes. It is suspected that positively charged quaternary ammonium ions are attracted to the net negative charge on the surface of most microbes.
  • the preferred quaternary ammonium compounds of the present disclosure release a positively charged quaternary ammonium ion in solution.
  • the preferred quaternary ammonium compounds of the present disclosure have at least one substituent group containing from 6 to 24 carbon atoms, typically from 8 to 20 carbon atoms; or, alternatively, two substituent groups that form an aliphatic or aromatic ring including the nitrogen atom.
  • the disclosed embodiments may contain an effective amount of a single quaternary ammonium compound or mixtures of two or more quaternary ammonium compounds.
  • quaternary ammonium compounds suitable for the disclosed invention include without limitation: n-alkyl dimethyl benzyl ammonium chloride, n-alkyl dimethyl ethylbenzyl ammonium chloride, n-alkyl dimethyl 3,4-dichlorobenzyl ammonium chloride, dioctyl dimethyl ammonium chloride, didecyl dimethyl ammonium chloride, cetyl pyridinium chloride, etc., and combinations thereof.
  • the composition of the present invention comprises 0.01 to 15 wt%, more preferably 0.05 to 10 wt% and most preferably 1 to 8 wt% of a first quaternary ammonium composition by weight of the antimicrobial composition.
  • the first quaternary ammonium composition comprises didecyl dimethyl ammonium chloride DDAC in the range of 0.01 to 15 wt% by weight of the antimicrobial composition, preferably 0.05 to 10 wt% and most preferably 1 to 8 wt% by weight of the antimicrobial composition.
  • 70 to 100 wt%, more preferably 80 to 100 wt% and most preferably 90 to 100 wt% of the total first quaternary ammonium composition is DDAC based on the weight of the total first quaternary ammonium composition.
  • DDAC Didecyl Dimethyl Ammonium Chloride
  • the first quaternary ammonium composition may further comprise other quaternary ammonium compounds such as n-alkyl dimethyl benzyl ammonium chloride, n-alkyl dimethyl ethylbenzyl ammonium chloride, n-alkyl dimethyl 3,4-dichlorobenzyl ammonium chloride, dioctyl dimethyl ammonium chloride, cetyl pyridinium chloride, etc., or derivatives, mixtures and combinations thereof.
  • other quaternary ammonium compounds such as n-alkyl dimethyl benzyl ammonium chloride, n-alkyl dimethyl ethylbenzyl ammonium chloride, n-alkyl dimethyl 3,4-dichlorobenzyl ammonium chloride, dioctyl dimethyl ammonium chloride, cetyl pyridinium chloride, etc., or derivatives, mixtures and combinations thereof.
  • Second Quaternary Ammonium Compound also comprises 0.01 to 15 % by weight of a second quaternary ammonium composition comprising benzalkonium chloride (BKC) or a derivative thereof.
  • BKC benzalkonium chloride
  • the second quaternary ammounium composition may additionally comprise benzathonium chloride (BEC).
  • BEC benzathonium chloride
  • the second quaternary ammonium composition may further comprise other quaternary ammonium compounds such as n-alkyl dimethyl 3,4-dichlorobenzyl ammonium chloride, dioctyl dimethyl ammonium chloride, cetyl pyridinium chloride, didecyl dimethyl ammonium chloride etc., or derivatives, mixtures and combinations thereof.
  • BKC Benzalkonium Chloride
  • BKC Benzalkonium chloride
  • alkyldimethylbenzylammonium chloride It is known to be used as a cationic surfactant and as a biocide. It has the following structure:
  • n 8, 10, 12, 14, 16, 18
  • the amount of BKC is preferably in the range of 0.01 to 15 wt%, more preferably 0.05 to 10 wt% and most preferably 1 to 8 wt% by weight of the antimicrobial composition.
  • BKC consists 70 to 100 wt%, more preferably 80 to 100 wt% and most preferably 90 to 100 wt% of the total second quaternary ammonium composition based on the weight of the total second quaternary ammonium composition.
  • BEC Benzethonium chloride
  • BEC is known for its antiseptic and anti-infective properties. It has been known to be used in cosmetic and toiletries compositions.
  • the amount of BEC is preferably in the range of 0.01 to 15 wt%, more preferably in the range of 0.05 to 10 wt% and most preferably in the range of 1 to 8 wt% by weight of the antimicrobial composition.
  • BEC consists 70 to 100 wt%, more preferably 80 to 100 wt% and most preferably 90 to 100 wt% of the total second quaternary ammonium composition based on the weight of the total second quaternary ammonium composition. More particularly the present invention provides an antimicrobial composition comprising: a. 0.01 to 15 wt% of a first quaternary ammonium composition comprising didecyl dimethyl ammonium chloride; and
  • BKC benzalkonium chloride
  • the antimicrobial composition comprises at most 10% wt of C2 to C3 monohydric alcohols
  • the additive concentration of non-ionic and anionic surfactant in the antimicrobial composition is less than 5 wt% based on the weight of the antimicrobial composition
  • the antimicrobial composition further comprises a pH indicator.
  • the ratio by weight of the antimicrobial composition of first quaternary ammonium composition to the second quaternary ammonium composition in the antimicrobial composition ranges from 10:1 to 1 :10, more preferably from 8:1 to 1 :8 and most preferably from 5:1 to 1 :5.
  • the ratio of DDAC to the second quaternary ammonium composition in the antimicrobial composition ranges from 10:1 to 1 :10, more preferably from 8:1 to 1 :8 and most preferably from 5:1 to 1 :5. It is further preferred that the ratio of DDAC to the BKC in the antimicrobial composition ranges from 10:1 to 1 :10, more preferably from 8:1 to 1 :8 and most preferably from 5:1 to 1 :5.
  • Water hardness i.e., high concentration of divalent cations reduces the rate of kill of most of the disinfectants because divalent cations (e.g., magnesium, calcium) in the hard water interact with the disinfectant to form insoluble precipitates.
  • divalent cations e.g., magnesium, calcium
  • Hardness is caused by compounds of calcium and magnesium, and by a variety of other metals.
  • General guidelines for classification of waters are: 0 to 60 mg/L (milligrams per liter) as calcium carbonate is classified as soft; 61 to 120 mg/L as moderately hard; 121 to 180 mg/L as hard; and more than 180 mg/L as very hard.
  • the present inventors have surprisingly found that the first and second quaternary ammonium compounds act synergistically to improve antimicrobial efficacy even in hard water conditions, which is not possible with any single quaternary ammonium compound taken in isolation.
  • the hard water conditions are defined as 120 to 180 mg/L (milligrams per liter) of calcium carbonate and most preferably, ⁇ 180 mg/L mg/L (milligrams per liter) of calcium carbonate.
  • the present invention is most preferably an aqueous antimicrobial composition having C2 to C3 monohydric alcohols at most 10 wt% by the weight of the antimicrobial composition.
  • the antimicrobial composition of the present invention is preferably 'substantially free' and more preferably 'essentially free' of C2 to C3 alcohols, and most preferably 'completely free' of C2 to C3 alcohols, which find their most common use in sanitizers.
  • the term 'substantially free' means less than 1 wt%, 'essentially free' means less than 0.01 wt% and 'completely free' means less than 2.0x10 "6 wt%.
  • the amount of C2 to C3 alcohols ranges from 0 to 5 wt%, more preferably from 0.0001 to 5 wt% and most preferably from 0.01 to 3 wt% based on the weight of the antimicrobial composition. It is preferred that the antimicrobial composition comprises at most 10 wt% of C2 to C3 alcohols, more preferably at most 8 wt%, even more preferably at most 5 wt%, even more preferably at most 2 wt%, even more preferably at most 1 % and most ideally 0%, in the order of preference, 0% being the ideal most preference.
  • C2 monohydric alcohol is ethanol and C3 monohydric alcohol is propanol.
  • the term C2 to C3 monohydric alcohols includes ethanol, propanol and derivatives such as isopropyl alcohol (isopropanol), n-propanol.
  • Non-ionic, anionic surfactant and amphoteric surfactants The additive concentration of non-ionic and anionic surfactant in the antimicrobial composition is less than 5% based on the weight of the antimicrobial composition. It is preferable that the antimicrobial composition of the present invention is 'substantially free' and more preferably 'essentially free' of non-ionic and anionic surfactant, and most preferably 'completely free' of non-ionic and anionic surfactant, which find their most common use in sanitizers.
  • the term 'substantially free' means less than 1 wt%, 'essentially free' means less than 0.01 wt% and 'completely free' means less than 2.0x 10 "6 wt%.
  • additive concentration of non-ionic and anionic surfactant ranges from 0 to 5 wt%, more preferably from 0.0001 to 5 wt% and most preferably from 0.01 to 3 wt% based on the weight of the antimicrobial composition. It is preferred that the antimicrobial composition comprises at most 5 wt% of non-ionic and anionic surfactant, more preferably at most 4 wt%, even more preferably at most 3 wt%, even more preferably at most 2 wt%, even more preferably at most 1 wt% and most ideally 0 wt%, in the order of preference, 0 wt% being the ideal most preference.
  • the antimicrobial composition of the present invention is preferably 'substantially free' and more preferably 'essentially free' of amphoteric surfactants, and most preferably 'completely free' of amphoteric surfactants, which find their most common use in sanitizers.
  • the term 'substantially free' means less than 1 wt%, 'essentially free' means less than 0.01 wt% and 'completely free' means less than 2.0x 10 "6 wt%.
  • the amount of amphoteric surfactant ranges from 0 to 5 wt%, more preferably from 0.0001 to 5 wt% and most preferably from 0.01 to 3 wt% based on the weight of the antimicrobial composition. It is preferred that the antimicrobial composition comprises at most 10 wt% of amphoteric surfactants, more preferably at most 8 wt%, even more preferably at most 5 wt%, even more preferably at most 2 wt%, even more preferably at most 1 wt% and most ideally 0 wt%, in the order of preference, 0 wt% being the ideal most preference.
  • the present antimicrobial composition is preferably an aqueous type of antimicrobial composition having water at least 70 wt%, more preferably at least 80 wt% and most preferably at least 85 wt%, based on the weight of the antimicrobial composition.
  • the suitable ranges of water in the antimicrobial composition are from 70 to 99 wt%, more preferably from 80 to 98 wt% and most preferably from 85 to 97.5 wt% based on the weight of the antimicrobial composition.
  • the antimicrobial compositions of the present invention include chelating agent in the range from 0.01 wt% to 3 wt%, more preferably from 0.01 to 2 wt% and most preferably from 0.05 to 1.5 wt% by weight of the antimicrobial composition. It is most preferred that the chelating agent comprises, most preferably is, a polydentate ligand.
  • the antimicrobial composition preferably comprises polydentate ligand in an amount of from 0.01 wt% to 3 wt%, more preferably from 0.01 to 2 wt% and most preferably from 0.05 to 1.5 wt% based on the weight of the antimicrobial composition.
  • Preferred chelating agents are as follows (names followed by their abbreviation in parenthesis):
  • Ethylene Diamine Tetra Acetic acid EDTA
  • Diethylene Triamine Penta Acetic acid DTPA
  • Ethane-1 -hydroxy-1 ,1-diphosphonate EHDP
  • Ethylene Diamine-N,N'-Disuccinate EDDS
  • Nitrilo Triacetic Acid NTA
  • EDDS Ethylene Diamine-N,N'-Disuccinate
  • NTA Nitrilo Triacetic Acid
  • Methyl Glycine Diacetic Acid MGDA
  • N-(2- hydroxyethyl) Ethylene Diamine ⁇ , ⁇ ', ⁇ '-Thacetic acid) HEDTA
  • Ethylene Diamine Tetra Methylene Phosphonic acid Ethylene Diamine ⁇ , ⁇ ', ⁇ '-Thacetic acid
  • Trisodium Ethylene Diamine Disuccinate Trisodium Ethylene Diamine Disuccinate, Tetra-sodium-lmino disuccinate, Glutamic acid- ⁇ , ⁇ diacetic acid tetra sodium salt, 2-hydroxyethyl iminodiacetic acid, Sodium salt (disodium ethanol diglycinate), Tetrasodium 3- hydroxy-2,2 imino disuccinate, Trisodium methylglycine diacetic acid, L- Aspartate-N,N-diacetic acid tetrasodium salt.
  • the more preferred chelating agents are salt of Ethylene Diamine Tetra Acetic acid (EDTA) and salt of Diethylene Thamine Penta Acetic acid (DTPA).
  • Preferred salts of EDTA are disodium Ethylene Diamine Tetra Acetic acid and tetrasodium Ethylene Diamine Tetra Acetic acid.
  • Preferred salt of DTPA is the pentasodium Diethylene Thamine Penta Acetic acid.
  • the present invention provides a method of disinfecting the surface of skin, the method comprising the steps of: Diluting the antimicrobial composition to at most to 5000 times, and washing the skin with the diluted antimicrobial composition. It is most preferable that the diluted antimicrobial composition is allowed to sit for at least 5 minutes before it is used for washing the skin.
  • the pH of the antimicrobial composition ranges from 2 to 7, more preferably from 3 to 6 and most preferably from 3.5 to 6. Dilution
  • the intended use of the present antimicrobial composition for personal wash is most suitable after diluting with water.
  • the dilution is at most 1 part of the antimicrobial composition with 5000 parts of water, it is most preferred that the dilution is at most 1 part of the antimicrobial composition with 3000 parts of water and most preferably the dilution is at most 1 part of the antimicrobial composition with 2000 parts of water.
  • the antimicrobial composition has a pH ranging from 2 to 7, preferably 2 to 6 and is preferably used in diluted form with water. Therefore, it is preferable to provide a pH indicator indicating that the pH of the diluted antimicrobial composition is close to the neutral pH- 7 which is most suitable for use as personal wash.
  • the pH of the antimicrobial composition after dilution with water is preferably in the range of 7 to 9, more preferably in the range of 7 to 8.5 most preferably in the range of 7 to 8.
  • the colour change is observed over a wide range of dilution i.e over 1 :500 to 1 :3000.
  • the conditions over which the actual experiments were carried out at was at 1 :2000.
  • the pH indicator is therefore preferable for a visual indication that the antimicrobial composition is suitably diluted and is good for use as personal wash.
  • suitable pH indicators available to the skilled artisan.
  • the protonated and deprotonated forms of the pH indicator have large differences in extinction coefficients (for example, 200 vs 18,000 M ' On "1 at 404 nm for 4-nitrophenol) which allows for good sensitivity.
  • Suitable pH indicators include but are not limited to chlorophenol red (pK a 6.0) useful for screening at a pH of approximately 6, 4-nitrophenol (pK a 7.2) useful for screening at a pH of approximately 7, phenol red (pK a 8.0) useful for screening at a pH of approximately 8, and thymol blue (pK a 9.2) useful for screening at a pH of approximately 9.
  • Other suitable indicators may be identified in the Merck Index (The Merck Index, 10th ed., Merck & Co., Rahway, NJ, 1983), Indicators (ed. By E.
  • an assay designed for use at pH 7.2 could use, for example, 4-nitrophenol as a pH indicator due to the similarity of its pK a (7.15) (The Merck Index, 10th ed., Merck & Co., Rahway, NJ, 1983, p. 950.) If the pK a of an indicator is not known, the pK a could be ascertained by measuring the midpoint of the pH change as standardized base is added. It should also be understood that the pKa may shift under different assay conditions, for example, cosolvent and ionic strength may change the pK a values and that the skilled artisan should take this into account.
  • Exemplary buffer-indicator combinations include but are not limited to the following: chlorophenol red (pK a 6.0) and MES (2-[N-morpholino]ethanesulfonic acid, pK a 6.1 ) for use at a pH of approximately 6; 4-nitrophenol (pK a 7.2) and BES (N,N-bis[2-hydroxyethyl]-2- aminoethanesulfonic acid, pK a 7.15) for use at a pH of approximately 7; phenol red (pK a 8.0) and EPPS (N-[2-hydroxylethyl]piperazine-N'-[3-propanesulfonic acid], pK a 8.0) for use at a pH of approximately 8; thymol blue (pK a 9.2) and, CHES (2-[N-cyclohexylamino]ethane-sulfonic acid, pK a 9.3) for use at a pH of approximately 9.
  • the buffer-indicator combination is BES (K,N-bis[2-hydroxyethyl]-2-aminoethanesulfonic acid) and 4-nitrophenol (pK a 7.2) because the pK a of BES (7.15) (Beynon, et al. Buffer Solutions, The Basics, IRL Press, Oxford, .1996, p. 72) is the same as that of 4-nitrophenol.
  • BES K,N-bis[2-hydroxyethyl]-2-aminoethanesulfonic acid
  • 4-nitrophenol pK a 7.2
  • BES K,N-bis[2-hydroxyethyl]-2-aminoethanesulfonic acid
  • pK a 7.2 4-nitrophenol
  • the preferred pH indicators the pH of the antimicrobial compositions prepared using them, the pH on dilution, the colour of the antimicrobial composition and the colour of the composition on dilution with water is give in Table -A below.
  • the pH indicator used in the antimicrobial composition is selected from cresol red, bromothymol blue, phenol red or cresol purple, more preferably from cresol red, bromothymol blue, or phenol red, and most preferably is bromothymol blue.
  • the present invention provides a disinfectant kit for providing personal washing, comprising the antimicrobial composition of the present invention, a dispensing container; and a set of instructions. It is highly preferable that the dispensing container comprises a nozzle, which is preferably capable of dispensing the antimicrobial composition in a drop wise manner. It is most preferable that the dispensing container contains the antimicrobial composition of the present invention.
  • the present invention provides a dispensing container containing the antimicrobial composition of the present invention.
  • the antimicrobial compositions may be provided in bottles, pump dispensers, tubes, sachets, or other packaging suitable for the product form. It is highly preferred that the antimicrobial composition of the invention is packaged in a dispensing container.
  • the dispensing container most preferably comprises a nozzle, which is preferably capable of dispensing the antimicrobial composition in a drop wise manner.
  • the present invention also provides the use of the antimicrobial composition of the present invention as a personal wash disinfectant liquid.
  • the present invention also provides use of benzalkonium chloride and didecyl dimethyl ammonium chloride as a disinfectant for use as a personal wash disinfectant liquid.
  • a preferred use of the antimicrobial composition of the present invention is for preparing a disinfecting aqueous solution by diluting the antimicrobial composition to at most to 5000 times with water.
  • the present invention provides use of 0.01 to 15 wt% of a first quaternary ammonium composition comprising didecyl dimethyl ammonium chloride or a derivative thereof; and 0.01 to 15 wt% of a second quaternary ammonium composition comprising benzalkonium chloride (BKC) or a derivative thereof; and a pH indicator as a disinfectant for use in personal hygiene.
  • a first quaternary ammonium composition comprising didecyl dimethyl ammonium chloride or a derivative thereof
  • BKC benzalkonium chloride
  • the present invention provides use of 0.01 to 15 wt% of a first quaternary ammonium composition comprising didecyl dimethyl ammonium chloride; and 0.01 to 15 wt% of a second quaternary ammonium composition comprising benzalkonium chloride (BKC); and a pH indicator as a disinfectant for use in personal hygiene.
  • the present invention provides use of the antimicrobial composition for providing disinfection in hard water.
  • the present invention provides use of 0.01 to 15 wt% of a first quaternary ammonium composition comprising didecyl dimethyl ammonium chloride or a derivative thereof; and 0.01 to 15 wt% of a second quaternary ammonium composition comprising a compound selected from benzalkonium chloride (BKC; and a pH indicator as a disinfectant in hard water.
  • BKC benzalkonium chloride
  • the present invention provides use of 0.01 to 15 wt% of a first quaternary ammonium composition comprising didecyl dimethyl ammonium chloride; and 0.01 to 15 wt% of a second quaternary ammonium composition comprising benzalkonium chloride (BKC) and a pH indicator as a disinfectant in hard water.
  • a first quaternary ammonium composition comprising didecyl dimethyl ammonium chloride
  • BKC benzalkonium chloride
  • the present invention also provides a method of manufacture of the antimicrobial composition, the method comprising adding the first quaternary ammonium composition and the second quaternary ammonium composition most preferably in water; and adding a pH indicator to obtain the antimicrobial composition.
  • the present invention also discloses a use of the antimicrobial composition of the present invention as disclosed above for improved antimicrobial benefit. More particularly the present invention discloses the use of a first quaternary ammonium composition comprising didecyl dimethyl ammonium chloride and a second quaternary ammonium composition comprising benzalkonium chloride (BKC) and a pH indicator in a topical antimicrobial composition for synergistic antimicrobial benefit.
  • BKC benzalkonium chloride
  • Synergistic antimicrobial benefit preferably means the antimicrobial composition of the invention is able to provide significantly better antimicrobial benefit when the individual component of the present antimicrobial composition used alone.
  • the inventors surprisingly found that, after application of the antimicrobial composition of the present invention the residual microbes on the surface are significantly less. Therefore the antimicrobial composition of the present invention able to provide antimicrobial benefits.
  • the preferred intended use of the antimicrobial composition of the present invention is non-therapeutic and/or cosmetic.
  • the formulations may optionally include a detersive surfactant in addition to the non- ionic surfactant.
  • detersive surfactants include, for example, anionic, zwitterionic and/or non-ionic surfactants.
  • anionic surfactants suitable for use herein include, but are not limited to, ammonium lauryl sulfate, ammonium laureth sulfate, triethylamine lauryl sulfate, triethylamine laureth sulfate, triethanolamine lauryl sulfate, triethanolamine laureth sulfate, monoethanolamine lauryl sulfate, monoethanolamine laureth sulfate, diethanolamine lauryl sulfate, diethanolamine laureth sulfate, lauric monoglyceride sodium sulfate, sodium lauryl sulfate, sodium laureth sulfate, potassium laureth sulfate, sodium lauryl sarcosinate, sodium lauroyl sarcosinate, potassium lauryl sulfate, sodium trideceth sulfate, sodium methyl lauroyl taurate, sodium lauroyl isethionate
  • the anionic surfactant may be, for example, an aliphatic sulfonate, such as a primary C8-C22 alkane sulfonate, primary C8-C22 alkane disulfonate, C8-C22 alkene sulfonate, C8-C22 hydroxyalkane sulfonate or alkyl glyceryl ether sulfonate.
  • an aliphatic sulfonate such as a primary C8-C22 alkane sulfonate, primary C8-C22 alkane disulfonate, C8-C22 alkene sulfonate, C8-C22 hydroxyalkane sulfonate or alkyl glyceryl ether sulfonate.
  • Zwitterionic surfactants suitable for use herein include, but are not limited to derivatives of aliphatic quaternary ammonium, phosphonium, and sulfonium compounds, in which the aliphatic radicals can be straight or branched chain, and wherein one of the aliphatic substituents contains from about 8 to about 18 carbon atoms and one substituent contains an anionic group, e.g., carboxy, sulfonate, sulfate, phosphate, or phosphonate.
  • Illustrative zwitterionic surfactants are coco dimethyl carboxymethyl betaine, cocoamidopropyl betaine, cocobetaine, oleyl betaine, cetyl dimethyl carboxymethyl betaine, lauryl bis-(2-hydroxyethyl) carboxymethyl betaine, stearyl bis-(2-hydroxypropyl) carboxymethyl betaine, oleyl dimethyl gamma-carboxypropyl betaine, lauryl bis-(2-hydroxypropyl)alpha-carboxyethyl betaine, and mixtures thereof.
  • the sulfobetaines may include stearyl dimethyl sulfopropyl betaine, lauryl dimethyl sulfoethyl betaine, lauryl bis-(2-hydroxyethyl) sulfopropyl betaine and mixtures thereof.
  • Suitable nonionic surfactants include the reaction products of compounds having a hydrophobic group and a reactive hydrogen atom, for example aliphatic alcohols or fatty acids, with alkylene oxides, especially ethylene oxide either alone or with propylene oxide. Examples include the condensation products of aliphatic (Cs-Cis) primary or secondary linear or branched alcohols with ethylene oxide, and products made by condensation of ethylene oxide with the reaction products of propylene oxide and ethylenediamine.
  • Other so-called nonionic surfactant compounds include long chain tertiary amine oxides, long chain tertiary phosphine oxides and dialkyi sulphoxides.
  • nonionics include mono or dialkyi alkanolamides or alkyl polyglucosides. Also useful are the alkyl polysaccharides.
  • nonionic surfactants include coco mono or diethanolamide, coco mono isopropanolamide, and coco di glucoside.
  • useful nonionic surfactants include the polyethylene, polypropylene, and polybutylene oxide condensates of alkyl phenols, fatty acid amide surfactants, polyhydroxy fatty acid amide surfactants, alkyl cthoxylate surfactants, alkanoyi glucose amide surfactants, and alkylpolyglycosides.
  • nonionic surfactants include alkanolamides such as cocainide DEA, cocamide MEA, cocamide MIPA, lauramide DEA, and lauramide MEA, sorbitan lauratc, sorbitan distcaratc, fatty acids or fatty acid esters such as lauric acid, and isostearic acid, fatty alcohols or ethoxylated fatty alcohols such as laiiryl alcohol, lauicth-4, laureth-7, laiireth-9, laureth-40, ti ' ideceth alcohol, Cn- 15 pareth-9, C12- 13 Pareth-3, and C14-15 Pareth-1 1 , alkylpolyglucosides such as decyl glucoside, lauryl glucoside, and coco glucoside.
  • the nonionic surfactant may also be a carbohydrate or sugar-based surfactant, ethers, esters or amides, such as alkyl (polyl
  • the nonionic surfactant may also be a sugar amide, such as a polysaccharide amide.
  • the surfactant may be one of the lactobionamides described in U.S. Patent No. 5,389,279 to Au et al. or it may be one of the sugar amides described in Patent No. 5,009,814 to Kelkenberg.
  • the formulations typically include one or more skin benefit agents.
  • skin benefit agent is defined as a substance which softens or improves the elasticity, appearance, and youthfulness of the skin (stratum corneum) by either increasing its water content, adding, or replacing lipids and other skin nutrients, or both, and keeps it soft by retarding the decrease of its water content.
  • suitable skin benefit agents include emollients, including, for example, hydrophobic emollients, hydrophilic emollients, or blends thereof.
  • Useful skin benefit agents include the following: (a) silicone oils and modifications thereof such as linear and cyclic polydimethylsiloxanes; amino, alkyl, alkylaryl, and aryl silicone oils; (b) fats and oils including natural fats and oils such as jojoba, soybean, sunflower, rice bran, avocado, almond, olive, sesame, persic, castor, coconut, and mink oils; cacao fat; beef tallow and lard; hardened oils obtained by hydrogenating the aforementioned oils; and synthetic mono, di and triglycerides such as myristic acid glyceride and 2-ethylhexanoic acid glyceride; (c) waxes such as carnauba, spermaceti, beeswax, lanolin, and derivatives thereof; (d) hydrophobic and hydrophilic plant extracts; (e) hydrocarbons such as liquid paraffin, petrolatum, microcrystalline wax, ceresin, squalene, pristan and
  • the antimicrobial composition may have sunscreen. Any sunscreen that can be suitably used with the base may be added. Both, UVA and UVB sunscreens may preferably be added.
  • the antimicrobial composition of the invention preferably comprises a UV- A sunscreen which is a dibenzoylmethane or its derivatives.
  • Preferred dibenzoylmethane derivatives are selected from 4-tert-butyl-4'-methoxydibenzoylmethane, 2-methyldibenzoylmethane, 4-methyl- dibenzoylmethane, 4-isopropyldibenzoyl-methane, 4-tert-butyldibenzoylmethane, 2,4- dimethyldibenzoylmethane, 2,5-dimethyldibenzoylmethane, 4,4'-diisopropyl- dibenzoylmethane, 2-methyl-5-isopropyl-4'-methoxydibenzoylmethane, 2-methyl-5-tert-butyl- 4'-methoxy-dibenzoyl methane, 2,4-dimethyl-4'- methoxy dibenzoyl
  • the most preferred dibenzoylmethane derivative is 4-tert.-butyl-4'-methoxydibenzoylmethane.
  • the antimicrobial composition of the invention preferably comprises 0.1 to 10%, more preferably 0.2 to 5%, further more preferably 0.4 to 3%, by weight dibenzoylmethane or a derivative thereof based on total weight of the antimicrobial composition and including all ranges subsumed therein.
  • the antimicrobial composition preferably comprises a UV-B organic sunscreen selected from the class of cinnamic acid, salicylic acid, diphenyl acrylic acid and derivatives thereof.
  • UV-B sunscreens which are commercially available and useful for inclusion in the antimicrobial composition of the invention are OctisalateTM, HomosalateTM, NeoHelipanTM, OctocryleneTM, OxybenzoneTM or Parsol MCXTM.
  • the UV-B sunscreen is most preferably 2-ethyl-hexyl-4-methoxy cinnamate which is commercially available as Parsol MCX.
  • the UV-B organic sunscreen is preferably included in 0.1 to 10%, more preferably 0.1 to 7 % by weight of the antimicrobial composition.
  • UV-B sunscreen like 2-ethyl-hexyl-4-methoxy cinnamate causes further rapid degradation of the UV-A dibenzoylmethane sunscreen in the presence of UV radiation.
  • the presence of the rosmarinic acid ester antimicrobial compound is found to be very efficacious in stabilizing the antimicrobial composition even when UV-B sunscreens are present.
  • Useful inorganic sun-blocks are also preferably used in the present invention. These include, for example, zinc oxide, iron oxide, silica, such as fumed silica, and titanium dioxide.
  • Skin benefit agents commonly account for up to 30wt.% of the liquid soap formulation, with levels of from 0 to 25wt.%, more particularly from 0 to 20wt%, being typical of the levels at which those skin benefit agents generally known as "emollients" are employed in many of the subject formulations.
  • Preferred skin benefit agents include fatty acids, hydrocarbons, polyhydric alcohols, polyols and mixtures thereof, with emollients that include at least one C12 to C18 fatty acid, petrolatum, glycerol, sorbitol and/or propylene glycol being of particular interest in one or more embodiments.
  • water soluble/dispersible polymers can be cationic, anionic, amphoteric or nonionic types with molecular weights higher than 100,000 Dalton. They are known to increase the viscosity and stability of liquid personal cleansing formulation, to enhance in-use and after-use skin sensory properties, and to enhance lather creaminess and lather stability. When present, the total amount of such polymers commonly ranges from 0.1 to 10% by weight of the personal cleansing formulation.
  • water soluble or dispersible polymers include the carbohydrate gums such as cellulose gum, microcrystalline cellulose, cellulose gel, hydroxyethyl cellulose, hydroxypropyl cellulose, sodium carboxymethylcellulose, methyl cellulose, ethyl cellulose, guar gum, gum karaya, gum tragacanth, gum arabic, gum acacia, gum agar, xanthan gum and mixtures thereof; modified and nonmodified starch granules and pregelatinized cold water soluble starch; emulsion polymers such as Aculyn® 28, Aculyn® 22 or Carbopol ⁇ Aqua SF1 ; cationic polymer such as modified polysaccharides including cationic guar available from Rhone Poulenc under the trade name Jaguar C13S, Jaguar C14S, Jaguar C17, or Jaguar C16; cationic modified cellulose such as UCARE Polymer JR 30 or JR 40 from Amerchol; N-Hance ® 3000, N
  • Preservatives/antimicrobials can desirably be incorporated into the personal cleansing formulations of this invention to protect against the growth of potentially harmful microorganisms.
  • Suitable traditional preservatives for formulations of this invention are alkyl esters of para-hydroxybenzoic acid.
  • Other preservatives/ antimicrobials which have more recently come into use include hydantoin derivatives, propionate salts, and a variety of quaternary ammonium compounds.
  • Among the preservatives/antimicrobials of particular interest are phenoxyethanol, methyl paraben, propyl paraben, imidazolidinyl urea, sodium dehydroacetate and benzyl alcohol.
  • preservatives of particular interest are dimethyloldimethylhydantoin (Glydant XL1000), parabens, sorbic acid, thymol and terpineol to name a few (with combinations of thymol and terpineol as described, for example, in U.S. Patent Application Publication No. 201 1/02231 14 incorporated herein by reference, being of particular interest in one or more embodiments).
  • the preservatives/antimicrobials should be selected having regard for the use of the formulation and possible incompatibilities between the preservatives and other ingredients.
  • Preservatives are preferably employed in amounts ranging from 0.01 to 2% by weight of the personal cleansing formulation.
  • Additional optional ingredients which may be present in the subject personal cleansing formulations are, for example: fragrances; pH adjusters; antioxidants, for example, butylated hydroxytoluene (BHT) and the like; stabilizers; suds boosters, such as for example, coconut acyl mono- or diethanol amides; ionizing salts, such as, for example, sodium chloride and sodium sulfate, and other ingredients such as are conventionally used in liquid soap formulations.
  • the total amount of such additional optional ingredients is typically from 0 to 10% by weight, more particularly from 0.1 to 5% by weight, based on the total weight of the personal cleansing formulation.
  • Appropriate solubilizing excipients may be used for incorporating the optional ingredients, benefit agents and fragrances.
  • antimicrobials such as 2-hydroxy-4,2',4'-trichlorodiphenylether (triclosan), 2,6-dimethyl-4-hydroxychlorobenzene, and 3,4,4'-trichlorocarbanilide
  • scrub and exfoliating particles such as polyethylene and silica or alumina
  • cooling agents such as menthol
  • skin calming agents such as aloe vera
  • colorants such as colorants.
  • the antimicrobial compositions may further include 0 to 10% by weight of opacifiers and pearlizers such as ethylene glycol distearate, titanium dioxide or Lytron® 621 (Styrene/Acrylate copolymer); all of which are useful in enhancing the appearance or properties of the product.
  • opacifiers and pearlizers such as ethylene glycol distearate, titanium dioxide or Lytron® 621 (Styrene/Acrylate copolymer); all of which are useful in enhancing the appearance or properties of the product.
  • Diluents other than water can include liquid or solid emollients, solvents, humectants, thickeners and powders.
  • Emollients such as stearyl alcohol, glyceryl monoricinoleate, mink oil, cetyl alcohol, isopropyl isostearate, stearic acid, isobutyl palmitate, isocetyl stearate, oleyl alcohol, isopropyl laurate, hexyl laurate, decyl oleate, octadecan-2-ol, isocetyl alcohol, eicosanyl alcohol, behenyl alcohol, cetyl palmitate, silicone oils such as dimethylpolysiloxane, di-n-butyl sebacate, isopropyl myristate, isopropyl palmitate, isopropyl steaxyl alcohol, stearyl alcohol, glyceryl monoricinoleate, mink oil,
  • active agents other than skin conditioning agents defined above may be added to the antimicrobial composition.
  • active ingredients may be advantageously selected from bactericides, vitamins, anti-acne actives; anti-wrinkle, anti-skin atrophy and skin repair actives; skin barrier repair actives; non-steroidal cosmetic soothing actives; artificial tanning agents and accelerators; skin lightening actives; sunscreen actives; sebum stimulators; sebum inhibitors; anti-oxidants; protease inhibitors; skin tightening agents; anti-itch ingredients; hair growth inhibitors; 5-alpha reductase inhibitors; desquamating enzyme enhancers; anti- glycation agents; or mixtures thereof; and the like.
  • active agents may be selected from water-soluble active agents, oil soluble active agents, pharmaceutically acceptable salts and mixtures thereof.
  • active agent means personal care actives which can be used to deliver a benefit to the skin and/or hair and which generally are not used to confer a skin conditioning benefit, such are delivered by emollients as defined above.
  • safe and effective amount means an amount of active agent high enough to modify the condition to be treated or to deliver the desired skin care benefit, but low enough to avoid serious side effects.
  • fit as used herein, means the therapeutic, prophylactic, and/or chronic benefits associated with treating a particular condition with one or more of the active agents described herein. What is a safe and effective amount of the active agent(s) will vary with the specific active agent, the ability of the active to penetrate through the skin, the age, health condition, and skin condition of the user, and other like factors.
  • the antimicrobial compositions of the present invention can comprise a wide range of other optional components.
  • CTFA Personal care Ingredient Handbook Second Edition, 1992, which is incorporated by reference herein in its entirety, describes a wide variety of non-limiting personal care and pharmaceutical ingredients commonly used in the skin care industry, which are suitable for use in the antimicrobial compositions of the present invention. Examples include: antioxidants, binders, biological additives, buffering agents, colorants, thickeners, polymers, astringents, fragrance, humectants, opacifying agents, conditioners, pH adjusters, natural extracts, essential oils, skin sensates, skin soothing agents, and skin healing agents.
  • the antimicrobial compositions of the present invention are prepared according to Table 1 .
  • Table 1 For a 100 g batch, 4.2 ml BKC and 4.48 ml of DDAC was mixed in 30ml water and to this mixture, a solution of 0.05 g of Bromothymol blue in 20 ml water was added. The remaining amount was made up with water.
  • the antimicrobial Compositions P1 and P2 are the preferred antimicrobial compositions of the present invention. Whereas, C1 and C2 are the control antimicrobial compositions which fall outside the scope of the present invention.
  • BS EN 1276 Proof of bactericidal efficacy.
  • BS EN 1276 is the European standard for the bactericidal activity of chemical disinfectants. In order to pass this standard, products must prove a bacteria kill rate of 99.999% within 5 minutes.
  • test bacterial suspension (1 .5-5 x 10 8 cfu /ml ) was then added. This was mixed in a tube and placed in a water bath controlled at test temperature of about 30°C for about 2 minutes and then 179.9 ml of water was added and mixed. To the above 0.1 ml of test formulation was added and mixed continuously.
  • 1 ml was aliquoted and transferred into a tube containing 8.0 ml neutralizer and 1.0 ml water for quenching the antimicrobial actives from further killing the microorganisms beyond the contact time of 5 minutes to obtain the neutralized test mixture.
  • the neutralized test mixture was mixed and placed in a water bath controlled at 30°C. After neutralization the neutralized test mixture of 1 .0 ml was taken in duplicate and inoculated using the pour plate.
  • the Antimicrobial efficacy as provided in Table 1 shows that the first and second quaternary ammonium compounds act synergistically to provide > 5 log kill in 5 minutes which provides excellent disinfectant property to the water treated with the antimicrobial composition of the present invention as compared to the Control antimicrobial compositions C1 and C2.
  • the compositions P1 and P2 also give a visual cue to the consumer when the colour changes from yellow to blue on dilution (1 :2000) that the compositions will be effective in synergistically killing the microorganisms thereby delivering the desired hygiene.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pest Control & Pesticides (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Birds (AREA)
  • Agronomy & Crop Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une composition antimicrobienne comprenant : 0,01 à 15 % en poids d'une première composition d'ammonium quaternaire comprenant du chlorure de didécyldiméthylammonium ou un dérivé de ce dernier ; et 0,01 à 15 % en poids d'une seconde composition d'ammonium quaternaire comprenant du chlorure de benzalkonium (BKC) ou un dérivé de ce dernier ; la composition antimicrobienne comprenant au plus 10 % en poids d'alcools monohydriques en C2 à C3 ; et la concentration d'additif de tensioactif non ionique et anionique dans la composition antimicrobienne étant inférieure à 5 % en poids par rapport au poids de la composition antimicrobienne ; et la composition antimicrobienne comprenant en outre un indicateur de pH.
PCT/EP2017/073390 2016-10-07 2017-09-18 Liquide désinfectant pour toilette personnelle Ceased WO2018065190A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN201780062189.9A CN109803532A (zh) 2016-10-07 2017-09-18 个人洗涤消毒液
MX2019003774A MX2019003774A (es) 2016-10-07 2017-09-18 Líquido desinfectante para lavado personal.
BR112019005645-9A BR112019005645B1 (pt) 2016-10-07 2017-09-18 Composição antimicrobiana, uso de uma composição antimicrobiana, kit desinfetante para lavagem pessoal, recipiente de distribuição e método de fabricação da composição antimicrobiana
ZA2019/01673A ZA201901673B (en) 2016-10-07 2019-03-18 Personal wash disinfectant liquid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16192728 2016-10-07
EP16192728.0 2016-10-07

Publications (1)

Publication Number Publication Date
WO2018065190A1 true WO2018065190A1 (fr) 2018-04-12

Family

ID=57121093

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2017/073390 Ceased WO2018065190A1 (fr) 2016-10-07 2017-09-18 Liquide désinfectant pour toilette personnelle

Country Status (4)

Country Link
CN (1) CN109803532A (fr)
MX (1) MX2019003774A (fr)
WO (1) WO2018065190A1 (fr)
ZA (1) ZA201901673B (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109316536A (zh) * 2018-10-22 2019-02-12 湖南中威制药有限公司 一种皮肤黏膜消毒剂及其制备方法
KR102202917B1 (ko) * 2020-07-24 2021-01-14 (주)뉴젠사이언스 살균효과를 갖는 소독용 조성물 및 그 제조 방법
CN118126780A (zh) * 2024-03-01 2024-06-04 江苏爱特福84股份有限公司 一种厨房用消杀洗涤剂及其制备方法
US20240381869A1 (en) * 2021-09-23 2024-11-21 Kimberly-Clark Worldwide, Inc. Color-Changing Sanitizing Compositions and Methods of Use

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112931502A (zh) * 2019-12-11 2021-06-11 山东菏泽三仪生物工程有限公司 一种复方戊二醛强化消毒剂及其制备方法
CN111436429A (zh) * 2020-03-20 2020-07-24 中国农业大学 一种环境消毒用药物组合物及其制备方法
CN112841187A (zh) * 2021-03-31 2021-05-28 康柏利科技（苏州）有限公司 一种衣物杀菌消毒液及其制备方法
CN113068719A (zh) * 2021-03-31 2021-07-06 康柏利科技（苏州）有限公司 一种多功能消毒除菌液及其制备方法
CN115299435A (zh) * 2022-05-30 2022-11-08 振德医疗用品股份有限公司 一种具有指示功能的消毒喷雾剂及制备方法与应用

Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3723325A (en) 1967-09-27 1973-03-27 Procter & Gamble Detergent compositions containing particle deposition enhancing agents
US4464398A (en) * 1981-08-11 1984-08-07 Huntington Laboratories, Inc. Germicide and an improved method for killing bacteria, fungus and/or viruses
US4565647A (en) 1982-04-26 1986-01-21 The Procter & Gamble Company Foaming surfactant compositions
US5009814A (en) 1987-04-08 1991-04-23 Huls Aktiengesellschaft Use of n-polyhydroxyalkyl fatty acid amides as thickening agents for liquid aqueous surfactant systems
EP0556957A1 (fr) 1992-01-23 1993-08-25 Unilever Plc Composition cosmétique pour le traitement de dessèchement cutané
US5389279A (en) 1991-12-31 1995-02-14 Lever Brothers Company, Division Of Conopco, Inc. Compositions comprising nonionic glycolipid surfactants
WO1995031958A1 (fr) 1994-05-20 1995-11-30 Lonza Inc. Desinfectants et agents d'assainissement a profil d'irritation oculaire potentielle reduit
WO2000065911A1 (fr) * 1999-04-30 2000-11-09 Sintal International, Inc. Composition antibacterienne et son emploi pour les soins de la peau et le traitement de tissus
US20050090414A1 (en) * 2003-10-23 2005-04-28 Sarah Rich Color changing hand soap composition
US20110223114A1 (en) 2008-10-20 2011-09-15 Amit Chakrabortty Antimicrobial composition
WO2013061082A1 (fr) * 2011-10-28 2013-05-02 Byotrol Plc Composition antimicrobienne
CN104188811A (zh) * 2014-07-30 2014-12-10 广州立白企业集团有限公司 一种泡沫型免洗抑菌洗手液及其使用方法
WO2015028806A1 (fr) * 2013-09-02 2015-03-05 Scoones Robert Liquide nettoyant
WO2016156869A2 (fr) * 2015-04-02 2016-10-06 Byotrol Plc Composition antimicrobienne

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101422149B (zh) * 2007-10-31 2011-08-17 李忠泽 以椰子油为基础原料制备的环保型高效消毒剂
AU2009201024B2 (en) * 2008-03-14 2013-10-24 Bissell Inc. Manual spray cleaner
US8772184B2 (en) * 2009-03-31 2014-07-08 Illinois Tool Works Inc. Reversible color-changing sanitizer-indicating nonwoven wipe

Patent Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3723325A (en) 1967-09-27 1973-03-27 Procter & Gamble Detergent compositions containing particle deposition enhancing agents
US4464398A (en) * 1981-08-11 1984-08-07 Huntington Laboratories, Inc. Germicide and an improved method for killing bacteria, fungus and/or viruses
US4565647B1 (en) 1982-04-26 1994-04-05 Procter & Gamble Foaming surfactant compositions
US4565647A (en) 1982-04-26 1986-01-21 The Procter & Gamble Company Foaming surfactant compositions
US5009814A (en) 1987-04-08 1991-04-23 Huls Aktiengesellschaft Use of n-polyhydroxyalkyl fatty acid amides as thickening agents for liquid aqueous surfactant systems
US5389279A (en) 1991-12-31 1995-02-14 Lever Brothers Company, Division Of Conopco, Inc. Compositions comprising nonionic glycolipid surfactants
EP0556957A1 (fr) 1992-01-23 1993-08-25 Unilever Plc Composition cosmétique pour le traitement de dessèchement cutané
WO1995031958A1 (fr) 1994-05-20 1995-11-30 Lonza Inc. Desinfectants et agents d'assainissement a profil d'irritation oculaire potentielle reduit
WO2000065911A1 (fr) * 1999-04-30 2000-11-09 Sintal International, Inc. Composition antibacterienne et son emploi pour les soins de la peau et le traitement de tissus
US20050090414A1 (en) * 2003-10-23 2005-04-28 Sarah Rich Color changing hand soap composition
US20110223114A1 (en) 2008-10-20 2011-09-15 Amit Chakrabortty Antimicrobial composition
WO2013061082A1 (fr) * 2011-10-28 2013-05-02 Byotrol Plc Composition antimicrobienne
WO2015028806A1 (fr) * 2013-09-02 2015-03-05 Scoones Robert Liquide nettoyant
CN104188811A (zh) * 2014-07-30 2014-12-10 广州立白企业集团有限公司 一种泡沫型免洗抑菌洗手液及其使用方法
WO2016156869A2 (fr) * 2015-04-02 2016-10-06 Byotrol Plc Composition antimicrobienne

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
"The CTFA Personal care Ingredient Handbook, 2nd ed.", 1992, .
"The Merck Index, 10th ed.", 1983, MERCK & CO., pages: 950
ANONYMOUS: "2-in-1 Foaming Sanitizer & Lotion Product Description", MINTEL GNPD, 1 January 2010 (2010-01-01), pages 1 - 3, XP055316127, Retrieved from the Internet <URL:http://www.gnpd.com/sinatra/recordpage/1245173/from_search/lrgwjMhvTk/?page=1> [retrieved on 20161103] *
ANONYMOUS: "Anti+Bac Original Multi Surface Cleaning Spray Product Description", MINTEL GNPD, 1 November 2015 (2015-11-01), pages 1 - 2, XP055316126, Retrieved from the Internet <URL:http://www.gnpd.com/sinatra/recordpage/3504061/from_search/Rfunvene9X/?page=1> [retrieved on 20161103] *
BEYNON ET AL.: "Buffer Solutions, The Basics", 1996, IRL PRESS, pages: 72
E. BISHOP: "Indicators", 1972, PERGAMON PRESS
FLOYD J. GREEN: "The Sigma-Aldrich Handbook of Stains, Dyes and Indicators", 1990, ALDRICH CHEMICAL COMPANY

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109316536A (zh) * 2018-10-22 2019-02-12 湖南中威制药有限公司 一种皮肤黏膜消毒剂及其制备方法
KR102202917B1 (ko) * 2020-07-24 2021-01-14 (주)뉴젠사이언스 살균효과를 갖는 소독용 조성물 및 그 제조 방법
US20240381869A1 (en) * 2021-09-23 2024-11-21 Kimberly-Clark Worldwide, Inc. Color-Changing Sanitizing Compositions and Methods of Use
CN118126780A (zh) * 2024-03-01 2024-06-04 江苏爱特福84股份有限公司 一种厨房用消杀洗涤剂及其制备方法

Also Published As

Publication number Publication date
CN109803532A (zh) 2019-05-24
BR112019005645A2 (pt) 2019-07-02
MX2019003774A (es) 2019-07-01
ZA201901673B (en) 2020-10-28

Similar Documents

Publication Publication Date Title
WO2018065190A1 (fr) Liquide désinfectant pour toilette personnelle
US10144908B2 (en) Liquid soap having enhanced antibacterial activity
US9655866B2 (en) Mild antibacterial cleansing compositions
BR112012006614A2 (pt) método para desinfetar a superfície, composição microbicida, composição microbicida líquida, sólido de composição microbicida e uso de uma composição
WO2024056586A2 (fr) Composition de nettoyage auto-moussante
US20240197593A1 (en) Cleansing composition for female intimate hygiene
BR112019005645B1 (pt) Composição antimicrobiana, uso de uma composição antimicrobiana, kit desinfetante para lavagem pessoal, recipiente de distribuição e método de fabricação da composição antimicrobiana
EP4392521A1 (fr) Compositions de soins à domicile
EP4146350B1 (fr) Composition antibactérienne
WO2025099148A1 (fr) Composition d&#39;hygiène personnelle liquide transparente
WO2024056587A1 (fr) Composition nettoyante auto-moussante
BR112022019870B1 (pt) Composições de limpeza antimicrobiana
WO2025040717A1 (fr) Composition de nettoyage
WO2025149303A1 (fr) Composition liquide pour l&#39;hygiène corporelle avec des propriétés bénéfiques pour la peau améliorées
WO2025149337A1 (fr) Composition topique d&#39;amélioration de la peau
WO2025149315A1 (fr) Compositions de nettoyage liquides pour l&#39;hygiène personnelle douces pour la peau
WO2019038067A1 (fr) Composition antimicrobienne
BR112015012443B1 (pt) Composição de limpeza, método de limpeza, uso da composição e método para prover limpeza

Legal Events

Date Code Title Description
DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 17777809

Country of ref document: EP

Kind code of ref document: A1

REG Reference to national code

Ref country code: BR

Ref legal event code: B01A

Ref document number: 112019005645

Country of ref document: BR

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 112019005645

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20190322

122 Ep: pct application non-entry in european phase

Ref document number: 17777809

Country of ref document: EP

Kind code of ref document: A1

WWG Wipo information: grant in national office

Ref document number: MX/A/2019/003774

Country of ref document: MX