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WO2017090740A1 - Composition contenant une structure bicellulaire - Google Patents

Composition contenant une structure bicellulaire Download PDF

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Publication number
WO2017090740A1
WO2017090740A1 PCT/JP2016/085005 JP2016085005W WO2017090740A1 WO 2017090740 A1 WO2017090740 A1 WO 2017090740A1 JP 2016085005 W JP2016085005 W JP 2016085005W WO 2017090740 A1 WO2017090740 A1 WO 2017090740A1
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WO
WIPO (PCT)
Prior art keywords
component
bicell structure
composition containing
bicell
skin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2016/085005
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English (en)
Japanese (ja)
Inventor
田中　健
裕也 門松
紺野　義一
純子 黒木
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kose Corp
Original Assignee
Kose Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kose Corp filed Critical Kose Corp
Priority to JP2017552736A priority Critical patent/JP6588568B2/ja
Priority to CN201680068176.8A priority patent/CN108289821B/zh
Priority to KR1020187012514A priority patent/KR102678109B1/ko
Publication of WO2017090740A1 publication Critical patent/WO2017090740A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A61K8/553—Phospholipids, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/0245—Specific shapes or structures not provided for by any of the groups of A61K8/0241
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid

Definitions

  • the present invention relates to a composition containing a bicell structure using phospholipids suitable for cosmetics and external preparations for skin, and more specifically, it can be prepared safely and simply without using an organic solvent. Further, the present invention relates to a composition having excellent usability as a skin external preparation and excellent storage stability.
  • the bicell structure is a disk-like molecular assembly (Fig. 1) in which the end of a bilayer flat membrane composed of long-chain phospholipids is covered with a surfactant such as short-chain phospholipids (Fig. 1). It is used for biological membrane research as a bilayer model. For example, solubilizing membrane proteins in a bicell structure is effective for structural analysis of membrane proteins using NMR (see Non-Patent Document 1). In addition, by applying the bicell structure, it penetrates into the stratum corneum of pig skin (see Non-Patent Document 2), penetrates into the stratum corneum of the three-dimensional cultured skin model, and affects the lamellar structure of the stratum corneum. It is known and attracts attention as a career.
  • micelles As carriers applied to the skin, micelles, vesicles and the like are already known. Micelles are colloids associated with surfactants that are capable of taking up small amounts of oil and are thermodynamically stable equilibrium systems. Therefore, it is used when a lipophilic active ingredient is blended in a dosage form such as a low-viscosity lotion. However, since micelles contain only a small amount of oil agent, it is impossible to stably mix active ingredients with high crystallinity such as cholesterol and phytosterol, and crystal precipitation may occur over time.
  • a vesicle is a closed vesicle having a bilayer structure formed by an amphiphile, but because of its specific structure, it can contain various active ingredients and as a carrier in a drug delivery system or the like. Has also attracted attention (see Patent Document 1). Further, when applied to the skin, vesicles have high retention in the stratum corneum and can effectively cause active ingredients to act, so that they are also effective as cosmetics and skin external preparations. Vesicles can be stably mixed with cholesterol and phytosterol, but their particle size is larger than that of the bicell structure, so that the permeability is inferior and the moisturizing effect may not be sufficient.
  • a composition containing a known bicell structure is generally prepared by the Bangham method. Specifically, lipid is uniformly dissolved in an organic solvent such as chloroform, the organic solvent is removed by an evaporator to form a thin film, and water is added and dispersed (see Non-Patent Document 3).
  • the preparation by the bangham method is excellent for preparation on a small scale, but since it is necessary to remove the solvent once, it is not suitable for mass production, and since an organic solvent such as chloroform is used, cosmetics and skin external preparations are used. It is not preferable as a method for preparing a composition that touches the human body.
  • the present invention can be prepared safely and easily without using an organic solvent, and is excellent in feeling of use as a cosmetic or a skin external preparation (penetration feeling, moisturizing feeling, feeling of firmness in the next morning), It is an object of the present invention to provide a composition containing a bicell structure excellent in storage stability.
  • a surfactant having a specific structure is combined with phospholipid, cholesterol and / or phytosterol at a specific ratio, and a specific dihydric alcohol or purified water is used.
  • a novel bicell structure was obtained, and it was found that the composition containing it had excellent usability and storage stability, and the present invention was completed.
  • the present invention provides the following components (a) to (e); (A) phospholipid (b) cholesterol and / or phytosterol (c) at least one selected from polyoxyethylene cholesteryl ether and / or polyoxyethylene phytosteryl ether, wherein the average added mole number of ethylene oxide is 10 to 20
  • Surfactant (d) Contains at least one dihydric alcohol (e) water selected from propylene glycol, dipropylene glycol, 1,3-butylene glycol, and contains the component (a) and the component (c)
  • the mass ratio (a) / (c) is 0.4 to 2.0, and the total mass ratio of the component (a) and the component (c) to the component (b) ⁇ (a) + (c) ⁇ / (B) is 5.0 or more, It is related with the composition containing the bicell structure characterized by the above-mentioned.
  • the present invention is a composition containing the bicell structure which is a cosmetic or an external preparation for skin, and the present invention further comprises the components (a), (b) and (c) dispersed in the component (d). Then, it is related with the manufacturing method of the composition containing the said bicell structure characterized by mixing and stirring with a component (e).
  • the composition containing the bicell structure of the present invention is excellent in storage stability, has a high permeation feeling when applied to the skin, and has a quality excellent in a moisturizing feeling and a feeling of firmness in the next morning. Therefore, the composition of the present invention is useful as a cosmetic or an external preparation for skin. Furthermore, in the lotion type, the composition is very transparent and can produce aesthetics.
  • a numerical range represented by using “to” means a range including numerical values described before and after “to” as a lower limit value and an upper limit value.
  • the composition containing the bicell structure of the present invention contains component (a) phospholipid.
  • the component (a) phospholipid is mainly used as a component of the bilayer structure of the bicell structure.
  • the phospholipid of component (a) refers to a substance having a structure in which fatty acid and phosphoric acid are bonded with glycerin or sphingosine as the central skeleton, and alcohol is ester-bonded to phosphoric acid.
  • fatty acids constituting phospholipids include saturated and unsaturated carboxylic acids having 7 to 22 carbon atoms, preferably 14 to 20 carbon atoms.
  • the alcohol constituting the phospholipid often contains nitrogen, and examples thereof include choline, ethanolamine, inositol, and serine.
  • the component (a) of the present invention is not particularly limited as long as it is used in ordinary cosmetics and skin external preparations.
  • soybean phospholipid, hydrogenated soybean phospholipid, egg yolk phospholipid, hydrogenated egg yolk phosphorus Lipids, sunflower phospholipids, hydrogenated sunflower phospholipids may be mentioned, and these may be used alone or in combination of two or more as required, more preferably hydrogenated soybean phospholipids, hydrogenated egg yolk phospholipids. It is done.
  • component (a) in the present invention is not particularly limited, but is preferably 0.01 to 5% by mass (hereinafter abbreviated as “%” in units), more preferably 0.05 to 3%. If it is this range, the composition which is more excellent in storage stability can be obtained.
  • the composition containing the bicell structure of the present invention contains component (b) cholesterol and / or phytosterol.
  • component (b) cholesterol and / or phytosterol.
  • the moisturizing feeling and the firmness of the next morning are improved, and the composition is particularly useful as a cosmetic or an external preparation for skin. If a component (b) is used for cosmetics and a skin external preparation, there will be no restriction
  • the content of component (b) in the present invention is 0.02 to 1%, and more preferably 0.05 to 0.5%.
  • the content of component (b) is less than 0.02%, the moisturizing feeling and the feeling of firmness in the next morning are lacking, and when the content of component (b) exceeds 1%, crystal precipitation is likely to occur, and storage stability. Becomes worse.
  • the composition containing the bicelle structure of the present invention is at least one selected from polyoxyethylene cholesteryl ether and / or polyoxyethylene phytosteryl ether, wherein component (c) has an average added mole number of ethylene oxide of 10 to 20.
  • the surfactant is contained.
  • the component (c) is mainly used as a component constituting the end portion of the bicell structure, and contributes to the stability of the bicell structure by packing with the component (a).
  • the average added mole number of ethylene oxide of component (c) is 10 to 20, and if it is outside this range, a bicell structure is not formed.
  • the components (c) POE (10) cholesteryl ether, POE (10) phytosteryl ether, and POE (20) phytosteryl ether are preferable.
  • Examples of these commercially available products include EMALEXCS-10 (manufactured by Nippon Emulsion Co., Ltd.), NIKKOL. Examples thereof include BPS-10 and BPS-20 (manufactured by Nippon Surfactant Kogyo Co., Ltd.), and one or a combination of two or more can be used as necessary.
  • the content of the component (c) in the present invention is not particularly limited, but is preferably 0.025 to 2.5%, more preferably 0.05 to 2.5%. If it is this range, the composition which is more excellent in storage stability and is further excellent in a moisturizing feeling can be obtained.
  • the mass ratio (a) / (c) of the component (a) and the component (c) is 0.4 to 2
  • the total mass ratio ⁇ (a) + (c) ⁇ / (b) of the component (a) and the component (c) is 5.0 or more. If it is outside this range, a bicell structure is not formed, or a composition exhibiting sufficient effects as a cosmetic or an external preparation for skin cannot be obtained.
  • composition containing the bicelle structure of the present invention contains at least one dihydric alcohol selected from component (d) propylene glycol, dipropylene glycol, and 1,3-butylene glycol.
  • component (d) is a solvent for dispersing component (a), component (b), and component (c) in water, and is a component for preparing a composition having excellent storage stability. These may be used alone or in combination of two or more as required.
  • the content of component (d) in the present invention is not particularly limited, but is preferably 1 to 40%, more preferably 10 to 30%. If it is this range, it is preferable from not only the storage stability of the composition containing a bicell structure but also the moisturizing effect especially excellent.
  • the composition containing the bicell structure of the present invention contains component (e) water.
  • the component (e) water is used as a dispersion medium for the bicell structure together with the component (d).
  • the component (e) is not particularly limited as long as it is used for cosmetics and skin external preparations.
  • electrolytic alkali Water such as ionic water, electrolytic acid ionic water, ionic water, cluster water, and steam-derived distilled water derived from plants such as lavender water, rose water, and orange flower water can be used.
  • the content of component (e) in the present invention is not particularly limited, but is preferably about 50 to 99%.
  • composition containing the bicell structure of the present invention is an optional component to be blended in a normal cosmetic or skin external preparation, specifically, within the range that does not interfere with the effects of the present invention and the formation of the bicell structure.
  • Oils, alcohols, powders, water-soluble polymers, film forming agents, surfactants other than the above components, oil-soluble gelling agents, organically modified clay minerals, resins, UV absorbers, antiseptics, antibacterial agents, perfumes Antioxidants, pH adjusters, chelating agents and the like can be added.
  • composition containing the bicell structure of the present invention can be produced by various methods for producing ordinary cosmetics and external preparations for skin.
  • Component (a) and component (b) are added to component (d).
  • a method in which the component (c) is dispersed and then mixed and stirred with the component (e) is preferable because it is suitable for mass production.
  • the component (a), the component (b) and the component (c) are dispersed in the component (d) preferably heated to a temperature of 70 ° C. to 90 ° C., more preferably about 80 ° C.
  • the stirring method at the time of preparation and cooling is not particularly limited, but examples of the equipment for dispersion treatment include a disper mixer, a homomixer, a bead mill and the like, and examples of equipment for high pressure treatment include a microfluidizer and the like. More preferably, these treatments can be performed under normal pressure.
  • a composition containing the bicell structure of the present invention can be obtained.
  • the existence and particle size of the bicell structure can be confirmed by observation with a transmission electron microscope (FIG. 2).
  • the average particle size of the bicellar structure of the present invention is preferably 10-60 nm, more preferably 15-40 nm, and 1-10 nm, more preferably 3-8 nm, short axis.
  • multi-layer vesicle particles may coexist, but if more than half of the particles in the observation field are bi-cell structures (disc-like images).
  • the effect as a composition containing the bicell structure of this invention is exhibited. That is, the ratio of the bicell structure in the present invention is represented by (number of disk images / number of all particle images) in the observation field by an electron microscope, and is 50% or more, preferably 75% or more, and more preferably 100%. .
  • the composition containing the bicell structure of the present invention may be used as it is as a cosmetic or skin external preparation, and after preparing the composition containing the bicell structure, it may be used in combination with other ingredients. It can also be used as a skin external preparation, and can be used as a cosmetic for various uses or as a skin external preparation.
  • skin care cosmetics such as skin lotion, milky lotion, cream, eye cream, beauty liquid, massage fee, pack fee, hand cream, body lotion, body cream, cosmetics such as cosmetic foundation cosmetics, external liquids, gels for external use
  • the external preparation for skin such as an agent, a cream, an ointment, a liniment, a lotion, a haptic, a plaster, a spray, and an aerosol.
  • the usage method includes a method of using by hand and fingers, a method of using by impregnating cotton or nonwoven fabric, and the like.
  • compositions having the compositions shown in Tables 1 to 3 were prepared.
  • the bicell structure was confirmed by observation with a transmission electron microscope and evaluated according to the following criteria (FIGS. 2 and 3). Further, the transmittance (transparency) and storage stability of the composition were evaluated by the following evaluation methods. These compositions were applied to the skin (entire face) as a cosmetic liquid and subjected to sensory evaluation based on the following method. The evaluation results are also shown in Tables 1 to 3.
  • Examples 1 to 13 were excellent in storage stability and, when applied to the skin as a cosmetic liquid, permeated quickly and had an excellent moisturizing effect. Further, the average particle diameter and the ratio of the bicell structure by electron microscope observation are 30 nm in the major axis and 3 to 5 nm in the minor axis, and the ratio is 100% in Example 1. In Example 6, the major axis is 50 nm and the minor axis is 3 to 3. The thickness was 5 nm and the ratio was 100%. On the other hand, Comparative Examples 1 to 7 not containing component (c) or component (d) and Comparative Examples 8 to 10 in which the content ratio of each component was out of the range did not form a bicell structure.
  • Example 14 lotion] (Ingredient) (%) 1. Hydrogenated egg yolk phospholipid 0.1 2. POE (10) cholesterol ether 0.1 3. Phytosterol 0.01 4). Cholesterol 0.01 5). Dipropylene glycol 10.0 6). 6. Purified water remaining amount Glycine 1.0 8). Theanine 1.0 9. Diglycerin 3.0 10. Ethanol 5.0 11. Preservative appropriate amount 12. Perfume
  • Example 15 Latex (Ingredient) (%) 1. Squalane 5.0 2. Decamethylcyclopentasiloxane 5.0 3. Polyoxyethylene (60) hydrogenated castor oil 2.0 4). Behenyl alcohol 0.5 6.1,3-Butylene glycol 7.0 7). Glycerin 5.0 8). Acrylic acid-alkyl methacrylate copolymer (Note 1) 0.2 9. Preservative appropriate amount10. Triethanolamine 0.2 11. Edetate disodium 0.02 12 Purified water remaining amount 13. Perfume appropriate amount14. Hydrogenated soybean phospholipid 1.0 15. POE (10) cholesteryl ether 0.6 16. POE (20) cholesteryl ether 0.7 17. Hydrogenated lysophospholipid 0.1 18. Cholesterol 0.1 19. Dipropylene glycol 7.0 20. Purified water 10.0 (Note 1) Pemulen TR-2 (manufactured by NOVEON)
  • Example 16 Cream] (Ingredient) (%) 1. Hydrogenated soybean phospholipid 2.0 2. Polyoxyethylene (20) sorbitan tristearate 3.0 3. Stearyl alcohol 5.0 4). Liquid paraffin 10.0 5). Avocado oil 5.0 6). Vaseline 3.0 7). Sorbitol 10.0 8). Purified water remaining 9. Ethanol 3.0 10. Preservative appropriate amount11. Perfume appropriate amount 12. Hydrogenated soybean phospholipid 1.5 13. POE (10) phytosteryl ether 1.3 14 Phytosterol 0.4 15. Hydroxylated soybean phospholipid 0.05 16. Propylene glycol 15.0 17. Purified water 10.0
  • Example 17 Sheet cosmetic] (Ingredient) (%) 1. Hydrogenated sunflower phospholipid 0.05 2. Soy phospholipid 0.05 3. POE (10) cholesteryl ether 0.03 4). POE (20) phytosteryl ether 0.05 5). Cholesterol 0.02 6). Phytosterol 0.01 7). Astaxanthin 0.001 8.1,3-Butylene glycol 10.0 9. Purified water remaining amount 10. Phenoxyethanol 1.0 11. Ethanol 5.0 12 Ascorbic acid glucoside 1.0 13. Sodium hyaluronate 0.2 14 Sodium hydroxide 0.13
  • Example 18 Creamy base cosmetic] (Ingredient) (%) 1. Zinc oxide (particle diameter 200nm) 2.0 2. Dimethylpolysiloxane 25.0 3. PEG-9 polydimethylsiloxane ethyl dimethicone 4.0 4). Isopropyl myristate 1.5 5). Acrylic-silicone graft copolymer mixture (Note 2) 2.0 6). 6. Purified water remaining amount Ethanol 5.0 8). Propylene glycol 5.0 9. Silica powder 2.0 10. Preservative appropriate amount11. Perfume appropriate amount 12. Hydrogenated soybean phospholipid 0.2 13. POE (5) phytosteryl ether 0.02 14 POE (10) phytosteryl ether 0.13 15. Cholesterol 0.1 16.
  • Dipropylene glycol 2.0 Dipropylene glycol 2.0 17.
  • Purified water 5.0 (Note 2)
  • KP-549 (acrylic-silicone graft copolymer 60%: methyltrimethicone 40% mixture) (manufactured by Shin-Etsu Chemical Co., Ltd.)
  • A Components (1) to (5) are subjected to dispersion treatment with a three-roll mill.
  • B Components (6) to (11) are mixed.
  • C A is added to B and emulsified.
  • D Components (12) to (16) are heated and dispersed at 80 ° C.
  • E The component (17) is heated to 80 ° C. and mixed and stirred while adding D to form a bicelle structure.
  • F was cooled and then added to C to obtain a creamy base cosmetic.
  • the creamy base cosmetic of Example 6 was a cosmetic having good storage stability, excellent penetration feeling, and excellent moisturizing effect.
  • Example 19 lotion] (Ingredient) (%) 1. Hydrogenated egg yolk phospholipid 0.65 2. POE (10) cholesterol ether 1.2 3. Cholesterol 0.15 4.1,3-Butylene glycol 20.0 5). Purified water remaining amount 6. Niacinamide 0.5 7). Preservative appropriate amount 8. Perfume
  • Example 19 Components (1) to (4) are heated and dispersed at 80 ° C.
  • B Component (5) is heated to 80 ° C.
  • C A is added to B and a bi-cell structure is formed with mixing and stirring, and then cooled to room temperature.
  • D Components (6) to (8) were added to C and mixed to obtain a skin lotion.
  • the bicell structure of Example 19 had an average particle diameter of 15 nm in major axis and 3 to 5 nm in minor axis, and the ratio of bicell structure was 100%, as observed by electron microscope.
  • the lotion of Example 19 was a cosmetic with good storage stability, excellent permeation, and excellent moisturizing effect.

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Abstract

La présente invention concerne une composition de structure bicellulaire pouvant être préparée sûrement et aisément sans utiliser de solvant organique, ayant une excellente sensation (sensation de pénétration, hydratation et tension) lorsqu'elle est utilisée en tant qu'agent externe pour la peau ainsi qu'une stabilité de conservation supérieure. La composition contenant une structure bicellulaire est caractérisée en ce qu'elle contient les composants (a) à (e) suivants : (a) un phospholipide ; (b) 0,02 à 1 % en masse de cholestérol et/ou phytostérol ; (c) au moins un tensioactif choisi parmi l'éther polyoxyéthylénique de cholestéryle et/ou l'éther polyoxyéthylénique de phytostéryle, dans laquelle le nombre moyen de moles ajoutées d'un oxyde d'éthylène est de 10 à 20 ; (d) au moins un alcool dihydrique choisi parmi le propylène glycol, le dipropylène glycol et le 1,3-butylène glycol ; et (e) de l'eau, le rapport massique de teneur (a) / (c) du composant (a) et du composant (c) étant de 0,4 à 2,0 et le rapport massique de teneur {(a) + (c)} / (b) de la somme du composant (a) et du composant (c) par rapport au composant (b) étant de 5,0 ou plus.
PCT/JP2016/085005 2015-11-26 2016-11-25 Composition contenant une structure bicellulaire Ceased WO2017090740A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2017552736A JP6588568B2 (ja) 2015-11-26 2016-11-25 バイセル構造体を含有する組成物
CN201680068176.8A CN108289821B (zh) 2015-11-26 2016-11-25 含有双层膜微胞构造体的组合物
KR1020187012514A KR102678109B1 (ko) 2015-11-26 2016-11-25 바이셀 구조체를 함유하는 조성물

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015-231172 2015-11-26
JP2015231172 2015-11-26

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WO2017090740A1 true WO2017090740A1 (fr) 2017-06-01

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WO2021070778A1 (fr) * 2019-10-10 2021-04-15 株式会社カネカ Nanodisque
JP2021138626A (ja) * 2020-03-03 2021-09-16 マイスターバイオ株式会社 化学構造が剛直な化合物を含有するバイセル及びそれを含有する外用組成物
JP2023097368A (ja) * 2021-12-27 2023-07-07 株式会社コーセー 皮膚外用組成物
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KR102618004B1 (ko) * 2023-03-28 2023-12-27 (주)삼경코스텍 난용성 유효 성분이 안정화 된 천연 유래 테르펜 글리코사이드 함유 바이셀 구조체 및 이의 제조방법

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JP2020019764A (ja) * 2018-07-23 2020-02-06 株式会社コーセー バイセル構造体を含有する組成物
JP7525250B2 (ja) 2018-07-23 2024-07-30 株式会社コーセー バイセル構造体を含有する組成物
WO2020066895A1 (fr) * 2018-09-28 2020-04-02 株式会社マンダム Composition cosmétique destinée à la peau
JPWO2020066895A1 (ja) * 2018-09-28 2021-04-01 株式会社マンダム 皮膚化粧料用組成物
WO2020175281A1 (fr) * 2019-02-28 2020-09-03 国立研究開発法人理化学研究所 Bicelle et son utilisation
JP2021014435A (ja) * 2019-07-12 2021-02-12 株式会社コーセー バイセル構造体を含有する組成物
JP7321015B2 (ja) 2019-07-12 2023-08-04 株式会社コーセー バイセル構造体を含有する組成物
WO2021070778A1 (fr) * 2019-10-10 2021-04-15 株式会社カネカ Nanodisque
JP2021138626A (ja) * 2020-03-03 2021-09-16 マイスターバイオ株式会社 化学構造が剛直な化合物を含有するバイセル及びそれを含有する外用組成物
JP2023097368A (ja) * 2021-12-27 2023-07-07 株式会社コーセー 皮膚外用組成物
JP7587563B2 (ja) 2021-12-27 2024-11-20 株式会社コーセー 皮膚外用組成物
WO2023157851A1 (fr) * 2022-02-16 2023-08-24 第一三共ヘルスケア株式会社 Composition aqueuse transparente

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