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WO2014190490A1 - 一种医用输药装置 - Google Patents

一种医用输药装置 Download PDF

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Publication number
WO2014190490A1
WO2014190490A1 PCT/CN2013/076335 CN2013076335W WO2014190490A1 WO 2014190490 A1 WO2014190490 A1 WO 2014190490A1 CN 2013076335 W CN2013076335 W CN 2013076335W WO 2014190490 A1 WO2014190490 A1 WO 2014190490A1
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WIPO (PCT)
Prior art keywords
drug delivery
controller
delivery device
medical
ultrasonic
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PCT/CN2013/076335
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English (en)
French (fr)
Inventor
姚广权
姚广智
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Individual
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Priority to PCT/CN2013/076335 priority Critical patent/WO2014190490A1/zh
Publication of WO2014190490A1 publication Critical patent/WO2014190490A1/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis

Definitions

  • the invention relates to the field of medical devices, in particular to a technology of a medical drug delivery device. Background technique
  • Intravenous and non-intravenous injections are usually delivered to patients in hospitals. Both methods require the needle to directly smash the skin for drug delivery.
  • Non-intravenous injection uses a syringe to suck the liquid into the syringe, then punctures the needle into the injection site such as the hips or arms of the person, pushes the plunger of the syringe and inputs the liquid into the patient, because the needle is directly smashed through the skin for loss.
  • Medicine so the first will increase the patient's pain, and secondly, if the disinfection is not in place, it is easy to cause infection. Thirdly, when the injection is used in this way, the sensitivity of human cells to drugs is weak, so the curative effect is not obvious.
  • Intravenous injections also have the disadvantage of non-intravenous injections.
  • the site of the acupuncture must be changed.
  • the needle should be re-clamped, which further increases the patient's pain, and for medical workers, The workload. Summary of the invention
  • the object of the present invention is to provide a medical treatment which can reduce the pain of the patient's body and mind, reduce the chance of infection, and increase the sensitivity of the human body to the drug and improve the curative effect without the need for the needle to break the skin.
  • Drug delivery device can reduce the pain of the patient's body and mind, reduce the chance of infection, and increase the sensitivity of the human body to the drug and improve the curative effect without the need for the needle to break the skin.
  • a medical drug delivery device characterized in that: the medical drug delivery device comprises an ultrasonic generator and a hollow body, the cavity body can be in close contact with the human skin and has a liquid penetration on the side close to the human skin.
  • the structure has an ultrasonic transducer in the cavity, the ultrasonic transducer is electrically connected to the ultrasonic generator through the wire, the cavity is connected with the drug delivery tube, and the venting tube is arranged on the cavity body, and the tube and a medical liquid are stored. Pump connection.
  • the ultrasonic transducer is an ultrasonic piezoelectric ceramic sheet.
  • the medical drug delivery device further comprises a controller, the controller is connected to a computer, the liquid medicine storage pump and the ultrasonic generator are controlled by the controller, and the pressure detecting probe is arranged in the liquid medicine after the output of the liquid medicine storage pump , the pressure detection probe is connected to the controller.
  • the medical drug delivery device further includes a controller, the controller is connected to a computer, the chemical liquid storage pump and the ultrasonic generator are controlled by the controller, and a pressure sensor is further disposed in the controller, and the pressure sensor signal pickup end and the air release pipe are provided. Connected.
  • An air detecting probe is disposed in the cavity, and the air detecting probe is connected to the controller.
  • the medical drug delivery device is provided with an audible and visual alarm for prompting the delivery of the drug, and the sound and light alarm device is controlled by the controller.
  • the drug in the cavity body and the drug delivery tube is a liquid drug solution, and the liquid drug solution is directly used as a coupling agent to be filled between the ultrasonic transducer and the skin.
  • the present invention has the following advantages over the prior art.
  • the invention comprises an ultrasonic generator and a hollow body, the hollow body can be in close contact with the human skin and has a liquid permeable structure on the side close to the human skin, and the ultrasonic transducer is arranged in the cavity, and the ultrasonic wave is exchanged.
  • the energy device is electrically connected to the ultrasonic generator through a wire, and the cavity body is connected with the medicine delivery tube, and a venting tube is arranged on the hollow body, and the medicine delivery tube is connected with a medical liquid storage pump, so that the ultrasonic body is used for the hollow body.
  • the drug solution is directly used as a coupling agent for drug delivery, so that it is not necessary to break the skin to transfer the drug, which reduces the patient's pain and reduces the chance of infection.
  • the ultrasonic wave has the following effects: 1. Mechanical effect, that is, the effect produced when the ultrasonic advances in the medium (the ultrasonic wave propagates in the medium is a mechanical effect caused by reflection), which can cause several reactions of the body, and ultrasonic vibration can cause Tissue cell movement, due to the subtle massage of ultrasound, the cytoplasm flow, cell oscillation, rotation, friction, and thus the role of cell massage, also known as "inner massage", this property can change the permeability of the cell membrane, The diffusion process of the semi-permeable membrane of the stimulating cell promotes metabolism, accelerates blood and lymph circulation, improves the state of ischemia and hypoxia, improves tissue nutrition, changes the rate of protein synthesis, enhances regenerative function, etc., and changes the internal structure of the cell, resulting in cells.
  • the functional changes make the hard connective tissue extend and soft. It can be seen that the mechanical action of ultrasound can soften the tissue, enhance the penetration, enhance metabolism, promote blood circulation, stimulate the nervous system and cell function; 2. Warming effect: human body Tissue has a relatively large absorption power for ultrasonic energy Therefore, when the ultrasonic wave propagates in the human tissue, its energy is continuously absorbed by the tissue and becomes heat. As a result, the temperature of the tissue itself rises, and the heat generation process is an energy conversion process in which mechanical energy is converted into heat energy in the medium, that is, Endogenous fever, ultrasound warming effect can increase blood circulation, accelerate metabolism, improve local tissue nutrition, and enhance enzyme activity. In summary, the ultrasonic action has A.
  • Ultrasound can improve the permeability of the biofilm, and after the ultrasonic wave, the permeability of the cell membrane to potassium and calcium ions is strongly changed. Increase Strong biofilm dispersion process, promote material exchange, accelerate metabolism, improve tissue nutrition; B. Thixotropy: Under ultrasound, it can transform gel into sol state, soften muscles, tendons, and some tissues and tissues Water-related pathological changes.
  • the invention utilizes ultrasonic waves to exert an effect on human skin tissue, thereby increasing the cell gap and improving cell membrane permeability.
  • the invention can be carried out by injecting liquid medicine without puncturing the skin, reducing the suffering of the patient, reducing the chance of infection, and better controlling the dose, increasing the sensitivity of the cell to the drug, and making the drug The effect is increased.
  • the medicine in the cavity body and the drug delivery tube is liquid, filling between the ultrasonic transducer and the skin, so as to fill the gap, preventing the air layer from generating interface reflection, so as to facilitate the passage of ultrasonic energy.
  • the liquid medicine is directly used as a coupling agent for drug delivery, which is also one of the characteristics distinguishing the present invention from other devices, because the coupling agent of other devices is in the form of a paste, and the drug is made into a paste and the drug is to be modified.
  • the invention can be used, and the invention is a liquid medicine which directly uses liquid, and does not need to modify the medicinal property, so it is beneficial to improve the curative effect.
  • the coupling agent of other devices is in the form of a paste, and a fixed amount of the drug is paste-formed in advance or absorbed by cotton or the like and then placed on the skin. Therefore, they cannot be continuously supplied, and only a good, fixed amount of medicine can be changed once and for all.
  • the invention is not liquid, and the medicine is a liquid medicine, so it can be continuously supplied.
  • 1 is a schematic structural view (1) of a medical drug delivery device of the present invention.
  • 2 is a schematic structural view (2) of a medical drug delivery device of the present invention.
  • the medical drug delivery device of the present invention comprises an ultrasonic generator 4 and a hollow body 1.
  • the hollow body 1 can be in close contact with the human skin 9 and is provided with liquid permeation on the side close to the human skin.
  • the cavity 1 is provided with an ultrasonic transducer 2, and the ultrasonic transducer 2 is electrically connected to the ultrasonic generator 4 through a wire 3, and the cavity 1 is connected to the drug delivery tube 7, and is provided on the cavity 1
  • the deflation tube 8 is provided with an air detecting probe 12 in the hollow body 1. At the front end of the venting pipe 8, the air detecting probe 12 is connected to the controller 5.
  • a shut-off switch 14 for the deflation tube 8 is provided in the controller 5, and the drug delivery tube 7 is connected to a medicinal solution storage pump 6.
  • the ultrasonic transducer 4 is an ultrasonic piezoelectric ceramic sheet.
  • the medical drug delivery device further includes a controller 5, the controller 5 is connected to a computer (not shown), and the drug solution storage pump 6 and the ultrasonic generator 4 are controlled by the controller 5, after the output of the drug storage pump 6
  • a pressure detecting device is provided in the liquid medicine, the pressure detecting device includes a probe 11, and the pressure detecting probe 11 is connected to the controller 5, and the pressure detecting probe 11 is disposed on the drug delivery tube near the hollow body 1 or near the hollow body 1. .
  • the frequency of the ultrasonic wave is 2.
  • the medical drug delivery device is provided with an audible and visual alarm for prompting the delivery of the drug, and the sound and light alarm is controlled by the controller.
  • the cavity body 1 and the drug delivery tube 7 are filled with the drug solution 10, and the ultrasonic detecting device 4 is activated by the pressure detecting probe 11 and the controller 5. Under the ultrasonic action of the ultrasonic transducer 4, the liquid medicine 10 is continuously turned to The human skin 9 is transported.
  • the sound and light alarm sounds a light and light alarm, prompting the delivery of the drug, so that the needle can be broken without breaking the skin, reducing the patient's pain and infection.
  • the pressure detection in the liquid medicine may also be performed by a pressure sensor 13 in the controller, and the pressure sensor signal picking is connected to the venting pipe 8 (not shown), and the vent pipe acts as a pressure transmission.
  • the dual role of the tube. The closing of the venting pipe 8 can be connected in parallel with the pressure sensor 13, and when the venting pipe is closed, the pressure sensor 13 starts to operate.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

一种医用输药装置，包括超声波发生器（4）和空腔体（1），空腔体（1）可贴紧于人体皮肤且在该侧设有液体渗透结构，空腔体（1）内设有超声波换能器（2）且通过导线（3）与超声波发生器（4）电连接，空腔体（1）与输药管（7）连通，在空腔体（1）上设有放气管，输药管（7）与一药液存储泵（6）连接。所述超声波换能器（2）为超声波压电陶瓷片，医用输药装置还包括一控制器（5），控制器（5）与一电脑连接，药液存储泵（6）、超声波发生器（4）由控制器（5）控制，在药液存储泵（6）输出后的药液中设有压力检测探头（11），压力检测探头（11）与控制器（5）连接。该医用输药装置不需要针刺破皮肤就能进行输药，无创伤，可减小病人的痛苦与受感染的机会，增加人体细胞对药物的敏感性，提高疗效。

Description

一种医用输药装置 技术领域
本发明涉及医疗器械领域， 具体来说是一种医用输药装置的技术。 背景技术
目前， 医院里输送药液到病人体内一般有静脉注射和非静脉注射， 这两种方式都需要针直接剌破皮肤进行输药。 非静脉注射利用注射器将 药液吸到注射器内， 然后将针剌入人们的臀部或手臂等注射部位， 推动 注射器的活塞而将药液输入到病人体内， 因为是用针直接剌破皮肤进行 输药， 所以第一会增加病人的痛苦， 其次是如果消毒不到位， 很容易发 生感染， 第三利用该种方式注射时， 人体细胞对药物的敏感性较弱， 因 此疗效不明显。 静脉注射， 同样存在非静脉注射的缺陷， 特别是要连续 几天输药时， 针剌的部位要改变， 这时又要重新扎针， 更加增加病人的 痛苦， 而且对于医务工作者来说， 增加了工作量。 发明内容
本发明的目的是提供一种不需要针剌破皮肤就能进行输药， 可减小 病人身心的痛苦， 减小受感染的机会， 而且可增加人体细胞对药物的敏 感性， 提高疗效的医用输药装置。
进一步的目的是可以连续输药
本发明的目的通过以下技术方案来实现。
一种医用输药装置， 其特征在于： 所述医用输药装置包括超声波发 生器和空腔体， 空腔体可贴紧于人体皮肤且在该贴紧于人体皮肤的一侧 设有液体渗透结构， 空腔体内设有超声波换能器， 超声波换能器通过导 线与超声波发生器电连接， 空腔体与输药管连通， 在空腔体上设有放气 管， 管与一药液存储泵连接。
所述超声波换能器为超声波压电陶瓷片。
所述输药医用输药装置还包括一控制器， 控制器与一电脑连接， 药 液存储泵、 超声波发生器由控制器控制， 在药液存储泵输出后的药液中 设有压力检测探头， 压力检测探头与控制器连接。 所述医用输药装置还包括一控制器， 控制器与一电脑连接， 药液存 储泵、 超声波发生器由控制器控制， 在控制器内还设有一压力传感器， 压力传感器信号拾取端与放气管相连。
所述空腔体内设有空气检测探头， 空气检测探头与控制器连接。 所述医用输药装置上设有提示输药输送完毕的声光报警器， 声光报 警器由控制器控制。
所述空腔体与输药管内的药物是液体药液， 液体药液直接作为耦合 剂， 充填于超声波换能器与皮肤之间。
本发明与现有技术相比具有以下优点。
本发明由于包括超声波发生器和空腔体， 空腔体可贴紧于人体皮肤 且在该贴紧于人体皮肤的一侧设有液体渗透结构， 空腔体内设有超声波 换能器， 超声波换能器通过导线与超声波发生器电连接， 空腔体与输药 管连通， 在空腔体上设有放气管， 输药管与一药液存储泵连接， 这样利 用超声波来以空腔体的药液直接作为耦合剂来进行输药， 因此不需要针 剌破皮肤就能进行输药， 这样减小了病人的痛苦， 减小了受感染的机会。 因为超声波具有以下的效应： 1、 机械效应， 即超声在介质中前进时所产 生的效应 （超声在介质中传播是由反射而产生的机械效应）， 它可引起机 体若干反应， 超声振动可引起组织细胞内物质运动， 由于超声的细微按 摩， 使细胞浆流动、 细胞震荡、 旋转、 摩擦、 从而产生细胞按摩的作用， 也称为 "内按摩" ， 这种特性可以改变细胞膜的通透性， 剌激细胞半透 膜的弥散过程， 促进新陈代谢、 加速血液和淋巴循环、 改善细胞缺血缺 氧状态， 改善组织营养、 改变蛋白合成率、 提高再生机能等， 使细胞内 部结构发生变化， 导致细胞的功能变化， 使坚硬的结缔组织延伸， 松软， 由此可知， 超声波的机械作用可软化组织， 增强渗透， 提高代谢， 促进 血液循环， 剌激神经系统和细胞功能； 2. 温热效应： 人体组织对超声能 量有比较大的吸收本领， 因此当超声波在人体组织中传播过程中， 其能 量不断地被组织吸收而变成热量， 其结果是组织的自身温度升高， 产热 过程是机械能在介质中转变成热能的能量转换过程， 即内生热， 超声温 热效应可增加血液循环， 加速代谢， 改善局部组织营养， 增强酶活力。 综上所述， 超声波作用有 A.弥散作用： 超声波可以提高生物膜的通透性， 超声波作用后， 细胞膜对钾， 钙离子的通透性发生较强的改变。 从而增 强生物膜弥散过程， 促进物质交换， 加速代谢， 改善组织营养； B.触变 作用： 超声作用下， 可使凝胶转化为溶胶状态， 对肌肉， 肌腱的软化作 用， 以及对一些与组织缺水有关的病理改变。 本发明正是利用超声波对 人体皮肤组织产生作用， 使其细胞间隙增加， 提高细胞膜通透性。 超声 在组织中传播时， 机械振动使人体组织中各质点受到交替变化的压力， 引起组织细胞内物质运动， 对细胞膜显示出微细的按摩作用， 提高其通 透性， 加强弥散过程， 有利于药物进入体内。 超声作用于组织细胞时， 在细胞内产生声流， 由于声流的作用， 细胞结构发生相位转变， 呈现新 的酶的中心， 使催化过程的趋向性发生改变， 细胞对药物的敏感性因此 而发生变化。 超声作用下引起的振动电位， 使细胞通透性增加。 由于细 胞膜通透性增加， 药物从细胞间隙极易进入细胞， 另在外部利用药液存 储泵对液体药物增加压力， 防止出现反渗透现象。 由此可见， 本发明是 使液体药物注射输送时不用剌破皮肤就可以进行， 减少了病人的痛苦， 减低感染的机会， 并且剂量控制较好， 使细胞的对药物的敏感性增加， 使药物的效果增加。
由于采用本发明的结构， 而且空腔体与输药管内的药物是液体， 充 填与超声波换能器与皮肤之间， 以便充填空隙， 防止有空气层而产生界 面反射， 以利超声能量通过， 也就是说以液体药物直接作为耦合剂进行 输药， 这也是本发明区别于其他装置的特征之一， 因为其他装置的耦合 剂是膏体状， 要将药制成膏体状并要改造药性才能用， 而本发明是直接 使用液体的药液， 不用改造药性， 故有利于提高疗效。 另外其他装置的 耦合剂是膏体状， 都是提前将固定量的药制成膏体状或用棉花之类的东 西吸收之后放在皮肤上的。 因此它们是不能连续供药的， 只能一次一次 地换造好的， 固定量的药。 而采用不发明， 其药物是液体药液， 所以是 可以连续供药的。
由于采用了控制器和相关的压力检测探头和空气检测探头， 可实现 全自动监控， 具有安全可靠， 使用方便的效果。
采用 2. 5MHZ超声波， 压力为 2KPA, 可达到 30分钟输入 5mL的效果。 附图说明
图 1为本发明医用输药装置结构示意图 （一）。 图 2为本发明医用输药装置结构示意图 （二）。 具体实施方式
下面结合附图对本发明医用输药装置作进一步详细描述。
如图 1所示，本发明医用输药装置，包括超声波发生器 4和空腔体 1， 空腔体 1可贴紧于人体皮肤 9且在该贴紧于人体皮肤的一侧设有液体渗 透结构， 空腔体 1内设有超声波换能器 2， 超声波换能器 2通过导线 3与 超声波发生器 4电连接， 空腔体 1与输药管 7连通， 在空腔体 1上设有 放气管 8， 空腔体 1 内设有空气检测探头 12， 在放气管 8的前端， 空气 检测探头 12与控制器 5连接。在控制器 5内设有放气管 8的关闭开关 14， 输药管 7与一药液存储泵 6连接。 超声波换能器 4为超声波压电陶瓷片。 医用输药装置还包括一控制器 5，控制器 5与一电脑（图中未示意出）连接， 药液存储泵 6、超声波发生器 4由控制器 5控制， 在药液存储泵 6输出后 的药液中设有压力检测装置， 压力检测装置包括探头 11， 压力检测探头 11与控制器 5连接，压力检测探头 11设置在靠近空腔体 1或靠近空腔体 1的输药管 Ί上。超声波的频率为 2. 5MHZ, 输药管内的药液压力为 2Kpa， 这时候可达到 30分钟输入 5mL的效果。 医用输药装置上设有提示输药输 送完毕的声光报警器， 声光报警器由控制器控制。 空腔体 1， 输药管 7内 均充满药液 10， 压力检测探头 11及控制器 5的作用下， 启动超声波发生 器 4， 在超声波换能器 4的超声作用下， 药液 10不断向人体皮肤 9内输 药， 当输药输送完毕， 声光报警器发出声光报警， 提示输药输送完毕， 这样不需要针剌破皮肤就能进行输药， 减小了病人的痛苦和受感染的机 会， 同时增加了人体细胞对药物的敏感性， 提高了疗效。
另外药液中的压力检测， 还可以是在控制器内还设有一压力传感器 13，压力传感器信号拾取与放气管 8相连的结构来实现（图中未示意出）， 此时放气管充当压力传递管的双重作用。 放气管 8 的关闭可与压力传感 器 13并联， 当放气管关闭后， 压力传感器 13开始工作。

Claims

权 利 要 求
1. 一种医用药装置， 其特征在于： 所述医用输药装置包括超声波发 生器和空腔体， 空腔体可贴紧于人体皮肤且在该贴紧于人体皮肤的一侧 设有液体渗透结构， 空腔体内设有超声波换能器， 超声波换能器通过导 线与超声波发生器电连接， 空腔体与输药管连通， 在空腔体上设有放气 管， 输药管与一药液存储泵连接。
2. 根据权利要求 1所述的医用输药装置， 其特征在于： 所述超声波 换能器为超声波压电陶瓷片。
3. 根据权利要求 1或 2所述的医用输药装置， 其特征在于： 所述医 用输药装置还包括一控制器， 控制器与一电脑连接， 药液存储泵、 超声 波发生器由控制器控制， 在药液存储泵输出后的药液中设有压力检测探 头， 压力检测探头与控制器连接。
4. 根据权利要求 1所述的医用输药装置， 其特征在于： 所述医用输 药装置还包括一控制器， 控制器与一电脑连接， 药液存储泵、 超声波发 生器由控制器控制， 在控制器内还设有一压力传感器， 压力传感器的信 号拾取端与放气管相连。
5. 根据权利要求 3所述的医用输药装置， 其特征在于： 所述空腔体 内设有空气检测探头， 空气检测探头与控制器连接。
6. 根据权利要求 3所述的医用输药装置， 其特征在于： 所述医用输 药装置上设有提示输药输送完毕的声光报警器， 声光报警器由控制器控 制。
7. 根据权利要求 3所述的医用输药装置， 其特征在于： 所述空腔体 与输药管内的药物是液体药液， 液体药液直接作为耦合剂， 充填于超声 波换能器与皮肤之间。
PCT/CN2013/076335 2013-05-28 2013-05-28 一种医用输药装置 Ceased WO2014190490A1 (zh)

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WO2007060741A1 (ja) * 2005-11-28 2007-05-31 Laseine Co., Ltd. 物質浸透方法およびその装置
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CN105879211A (zh) * 2015-01-26 2016-08-24 李明德 远场连续型治疗超声波探头

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