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WO2014190490A1 - Dispositif médical d'administration de médicament - Google Patents

Dispositif médical d'administration de médicament Download PDF

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Publication number
WO2014190490A1
WO2014190490A1 PCT/CN2013/076335 CN2013076335W WO2014190490A1 WO 2014190490 A1 WO2014190490 A1 WO 2014190490A1 CN 2013076335 W CN2013076335 W CN 2013076335W WO 2014190490 A1 WO2014190490 A1 WO 2014190490A1
Authority
WO
WIPO (PCT)
Prior art keywords
drug delivery
controller
delivery device
medical
ultrasonic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2013/076335
Other languages
English (en)
Chinese (zh)
Inventor
姚广权
姚广智
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to PCT/CN2013/076335 priority Critical patent/WO2014190490A1/fr
Publication of WO2014190490A1 publication Critical patent/WO2014190490A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis

Definitions

  • the invention relates to the field of medical devices, in particular to a technology of a medical drug delivery device. Background technique
  • Intravenous and non-intravenous injections are usually delivered to patients in hospitals. Both methods require the needle to directly smash the skin for drug delivery.
  • Non-intravenous injection uses a syringe to suck the liquid into the syringe, then punctures the needle into the injection site such as the hips or arms of the person, pushes the plunger of the syringe and inputs the liquid into the patient, because the needle is directly smashed through the skin for loss.
  • Medicine so the first will increase the patient's pain, and secondly, if the disinfection is not in place, it is easy to cause infection. Thirdly, when the injection is used in this way, the sensitivity of human cells to drugs is weak, so the curative effect is not obvious.
  • Intravenous injections also have the disadvantage of non-intravenous injections.
  • the site of the acupuncture must be changed.
  • the needle should be re-clamped, which further increases the patient's pain, and for medical workers, The workload. Summary of the invention
  • the object of the present invention is to provide a medical treatment which can reduce the pain of the patient's body and mind, reduce the chance of infection, and increase the sensitivity of the human body to the drug and improve the curative effect without the need for the needle to break the skin.
  • Drug delivery device can reduce the pain of the patient's body and mind, reduce the chance of infection, and increase the sensitivity of the human body to the drug and improve the curative effect without the need for the needle to break the skin.
  • a medical drug delivery device characterized in that: the medical drug delivery device comprises an ultrasonic generator and a hollow body, the cavity body can be in close contact with the human skin and has a liquid penetration on the side close to the human skin.
  • the structure has an ultrasonic transducer in the cavity, the ultrasonic transducer is electrically connected to the ultrasonic generator through the wire, the cavity is connected with the drug delivery tube, and the venting tube is arranged on the cavity body, and the tube and a medical liquid are stored. Pump connection.
  • the ultrasonic transducer is an ultrasonic piezoelectric ceramic sheet.
  • the medical drug delivery device further comprises a controller, the controller is connected to a computer, the liquid medicine storage pump and the ultrasonic generator are controlled by the controller, and the pressure detecting probe is arranged in the liquid medicine after the output of the liquid medicine storage pump , the pressure detection probe is connected to the controller.
  • the medical drug delivery device further includes a controller, the controller is connected to a computer, the chemical liquid storage pump and the ultrasonic generator are controlled by the controller, and a pressure sensor is further disposed in the controller, and the pressure sensor signal pickup end and the air release pipe are provided. Connected.
  • An air detecting probe is disposed in the cavity, and the air detecting probe is connected to the controller.
  • the medical drug delivery device is provided with an audible and visual alarm for prompting the delivery of the drug, and the sound and light alarm device is controlled by the controller.
  • the drug in the cavity body and the drug delivery tube is a liquid drug solution, and the liquid drug solution is directly used as a coupling agent to be filled between the ultrasonic transducer and the skin.
  • the present invention has the following advantages over the prior art.
  • the invention comprises an ultrasonic generator and a hollow body, the hollow body can be in close contact with the human skin and has a liquid permeable structure on the side close to the human skin, and the ultrasonic transducer is arranged in the cavity, and the ultrasonic wave is exchanged.
  • the energy device is electrically connected to the ultrasonic generator through a wire, and the cavity body is connected with the medicine delivery tube, and a venting tube is arranged on the hollow body, and the medicine delivery tube is connected with a medical liquid storage pump, so that the ultrasonic body is used for the hollow body.
  • the drug solution is directly used as a coupling agent for drug delivery, so that it is not necessary to break the skin to transfer the drug, which reduces the patient's pain and reduces the chance of infection.
  • the ultrasonic wave has the following effects: 1. Mechanical effect, that is, the effect produced when the ultrasonic advances in the medium (the ultrasonic wave propagates in the medium is a mechanical effect caused by reflection), which can cause several reactions of the body, and ultrasonic vibration can cause Tissue cell movement, due to the subtle massage of ultrasound, the cytoplasm flow, cell oscillation, rotation, friction, and thus the role of cell massage, also known as "inner massage", this property can change the permeability of the cell membrane, The diffusion process of the semi-permeable membrane of the stimulating cell promotes metabolism, accelerates blood and lymph circulation, improves the state of ischemia and hypoxia, improves tissue nutrition, changes the rate of protein synthesis, enhances regenerative function, etc., and changes the internal structure of the cell, resulting in cells.
  • the functional changes make the hard connective tissue extend and soft. It can be seen that the mechanical action of ultrasound can soften the tissue, enhance the penetration, enhance metabolism, promote blood circulation, stimulate the nervous system and cell function; 2. Warming effect: human body Tissue has a relatively large absorption power for ultrasonic energy Therefore, when the ultrasonic wave propagates in the human tissue, its energy is continuously absorbed by the tissue and becomes heat. As a result, the temperature of the tissue itself rises, and the heat generation process is an energy conversion process in which mechanical energy is converted into heat energy in the medium, that is, Endogenous fever, ultrasound warming effect can increase blood circulation, accelerate metabolism, improve local tissue nutrition, and enhance enzyme activity. In summary, the ultrasonic action has A.
  • Ultrasound can improve the permeability of the biofilm, and after the ultrasonic wave, the permeability of the cell membrane to potassium and calcium ions is strongly changed. Increase Strong biofilm dispersion process, promote material exchange, accelerate metabolism, improve tissue nutrition; B. Thixotropy: Under ultrasound, it can transform gel into sol state, soften muscles, tendons, and some tissues and tissues Water-related pathological changes.
  • the invention utilizes ultrasonic waves to exert an effect on human skin tissue, thereby increasing the cell gap and improving cell membrane permeability.
  • the invention can be carried out by injecting liquid medicine without puncturing the skin, reducing the suffering of the patient, reducing the chance of infection, and better controlling the dose, increasing the sensitivity of the cell to the drug, and making the drug The effect is increased.
  • the medicine in the cavity body and the drug delivery tube is liquid, filling between the ultrasonic transducer and the skin, so as to fill the gap, preventing the air layer from generating interface reflection, so as to facilitate the passage of ultrasonic energy.
  • the liquid medicine is directly used as a coupling agent for drug delivery, which is also one of the characteristics distinguishing the present invention from other devices, because the coupling agent of other devices is in the form of a paste, and the drug is made into a paste and the drug is to be modified.
  • the invention can be used, and the invention is a liquid medicine which directly uses liquid, and does not need to modify the medicinal property, so it is beneficial to improve the curative effect.
  • the coupling agent of other devices is in the form of a paste, and a fixed amount of the drug is paste-formed in advance or absorbed by cotton or the like and then placed on the skin. Therefore, they cannot be continuously supplied, and only a good, fixed amount of medicine can be changed once and for all.
  • the invention is not liquid, and the medicine is a liquid medicine, so it can be continuously supplied.
  • 1 is a schematic structural view (1) of a medical drug delivery device of the present invention.
  • 2 is a schematic structural view (2) of a medical drug delivery device of the present invention.
  • the medical drug delivery device of the present invention comprises an ultrasonic generator 4 and a hollow body 1.
  • the hollow body 1 can be in close contact with the human skin 9 and is provided with liquid permeation on the side close to the human skin.
  • the cavity 1 is provided with an ultrasonic transducer 2, and the ultrasonic transducer 2 is electrically connected to the ultrasonic generator 4 through a wire 3, and the cavity 1 is connected to the drug delivery tube 7, and is provided on the cavity 1
  • the deflation tube 8 is provided with an air detecting probe 12 in the hollow body 1. At the front end of the venting pipe 8, the air detecting probe 12 is connected to the controller 5.
  • a shut-off switch 14 for the deflation tube 8 is provided in the controller 5, and the drug delivery tube 7 is connected to a medicinal solution storage pump 6.
  • the ultrasonic transducer 4 is an ultrasonic piezoelectric ceramic sheet.
  • the medical drug delivery device further includes a controller 5, the controller 5 is connected to a computer (not shown), and the drug solution storage pump 6 and the ultrasonic generator 4 are controlled by the controller 5, after the output of the drug storage pump 6
  • a pressure detecting device is provided in the liquid medicine, the pressure detecting device includes a probe 11, and the pressure detecting probe 11 is connected to the controller 5, and the pressure detecting probe 11 is disposed on the drug delivery tube near the hollow body 1 or near the hollow body 1. .
  • the frequency of the ultrasonic wave is 2.
  • the medical drug delivery device is provided with an audible and visual alarm for prompting the delivery of the drug, and the sound and light alarm is controlled by the controller.
  • the cavity body 1 and the drug delivery tube 7 are filled with the drug solution 10, and the ultrasonic detecting device 4 is activated by the pressure detecting probe 11 and the controller 5. Under the ultrasonic action of the ultrasonic transducer 4, the liquid medicine 10 is continuously turned to The human skin 9 is transported.
  • the sound and light alarm sounds a light and light alarm, prompting the delivery of the drug, so that the needle can be broken without breaking the skin, reducing the patient's pain and infection.
  • the pressure detection in the liquid medicine may also be performed by a pressure sensor 13 in the controller, and the pressure sensor signal picking is connected to the venting pipe 8 (not shown), and the vent pipe acts as a pressure transmission.
  • the dual role of the tube. The closing of the venting pipe 8 can be connected in parallel with the pressure sensor 13, and when the venting pipe is closed, the pressure sensor 13 starts to operate.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un dispositif médical d'administration de médicaments, comprenant un générateur ultrasonique (4) et un corps de cavité (1), le corps de cavité (1) pouvant être pressé étroitement contre la peau humaine et présentant une structure de perméation de liquide placée dans le côté, et un transducteur ultrasonique (2) étant agencé à l'intérieur du corps de cavité (1), le transducteur ultrasonique (2) étant connecté électriquement au générateur ultrasonique (4) via un fil (3) et le corps de cavité (1) étant en communication avec un tube d'administration de médicament (7) présentant un tube de purge placé dans le corps de cavité (1) et le tube d'administration de médicament (7) étant relié à une pompe de stockage (6) d'un médicament liquide. Le transducteur ultrasonique (2) est une pièce céramique piézoélectrique ultrasonique et le dispositif d'administration de médicament comprend également un dispositif de commande (5) connecté à un ordinateur et la pompe de stockage (6) d'un médicament liquide et le générateur ultrasonique (4) sont commandés par le dispositif de commande (5). Une sonde de test de la pression (11), qui est connectée au dispositif de commande (5), est disposée dans le médicament liquide après que celui-ci a été expulsé par la pompe de stockage (6) d'un médicament liquide. Le dispositif médical d'administration de médicament ne doit pas perforer la peau à l'aide d'une aiguille pour administrer le médicament, ne provoque pas de traumatisme, peut réduire la douleur et les risques d'infection du patient et augmente la sensibilité au médicament de cellules humaines, améliorant ainsi les effets thérapeutiques.
PCT/CN2013/076335 2013-05-28 2013-05-28 Dispositif médical d'administration de médicament Ceased WO2014190490A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2013/076335 WO2014190490A1 (fr) 2013-05-28 2013-05-28 Dispositif médical d'administration de médicament

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2013/076335 WO2014190490A1 (fr) 2013-05-28 2013-05-28 Dispositif médical d'administration de médicament

Publications (1)

Publication Number Publication Date
WO2014190490A1 true WO2014190490A1 (fr) 2014-12-04

Family

ID=51987851

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2013/076335 Ceased WO2014190490A1 (fr) 2013-05-28 2013-05-28 Dispositif médical d'administration de médicament

Country Status (1)

Country Link
WO (1) WO2014190490A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105879211A (zh) * 2015-01-26 2016-08-24 李明德 远场连续型治疗超声波探头

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1100959A (zh) * 1993-09-28 1995-04-05 翟大海 脉冲热渗仪
WO2007060741A1 (fr) * 2005-11-28 2007-05-31 Laseine Co., Ltd. Méthode d'infiltration de substance et appareil à cet usage
CN101468232A (zh) * 2007-12-28 2009-07-01 朱晓义 人体补给装置
CN101670143A (zh) * 2008-09-11 2010-03-17 姚广权 一种医用输药装置
KR101022201B1 (ko) * 2009-12-22 2011-03-16 강원대학교산학협력단 경피약물전달 촉진을 위한 초음파 장치

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1100959A (zh) * 1993-09-28 1995-04-05 翟大海 脉冲热渗仪
WO2007060741A1 (fr) * 2005-11-28 2007-05-31 Laseine Co., Ltd. Méthode d'infiltration de substance et appareil à cet usage
CN101468232A (zh) * 2007-12-28 2009-07-01 朱晓义 人体补给装置
CN101670143A (zh) * 2008-09-11 2010-03-17 姚广权 一种医用输药装置
KR101022201B1 (ko) * 2009-12-22 2011-03-16 강원대학교산학협력단 경피약물전달 촉진을 위한 초음파 장치

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105879211A (zh) * 2015-01-26 2016-08-24 李明德 远场连续型治疗超声波探头

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