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WO2013019051A3 - Method for producing retinoid from microorganism - Google Patents

Method for producing retinoid from microorganism Download PDF

Info

Publication number
WO2013019051A3
WO2013019051A3 PCT/KR2012/006071 KR2012006071W WO2013019051A3 WO 2013019051 A3 WO2013019051 A3 WO 2013019051A3 KR 2012006071 W KR2012006071 W KR 2012006071W WO 2013019051 A3 WO2013019051 A3 WO 2013019051A3
Authority
WO
WIPO (PCT)
Prior art keywords
microorganism
retinoid
producing
producing retinoid
lipophilic substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2012/006071
Other languages
French (fr)
Korean (ko)
Other versions
WO2013019051A9 (en
WO2013019051A2 (en
Inventor
김선원
장희정
윤상활
하보경
류희경
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gyeongsang National University GNU
Original Assignee
Gyeongsang National University GNU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gyeongsang National University GNU filed Critical Gyeongsang National University GNU
Priority to US14/235,841 priority Critical patent/US9644217B2/en
Priority to CN201280042839.0A priority patent/CN103857786B/en
Priority claimed from KR1020120083185A external-priority patent/KR101392159B1/en
Publication of WO2013019051A2 publication Critical patent/WO2013019051A2/en
Publication of WO2013019051A9 publication Critical patent/WO2013019051A9/en
Publication of WO2013019051A3 publication Critical patent/WO2013019051A3/en
Anticipated expiration legal-status Critical
Priority to US15/180,032 priority patent/US9834794B2/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes

Landscapes

  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention relates to a method for producing retinoid from a microorganism, and more specifically, to a method for effectively obtaining retinoid, which lacks stability, from a microorganism by cultivating the microorganism capable of producing retinoid in a medium containing a lipophilic substance, and separating retinoid from the lipophilic substance.
PCT/KR2012/006071 2011-07-29 2012-07-30 Method for producing retinoid from microorganism Ceased WO2013019051A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US14/235,841 US9644217B2 (en) 2011-07-29 2012-07-30 Method for producing retinoid from microorganism
CN201280042839.0A CN103857786B (en) 2011-07-29 2012-07-30 Method for producing retinoids from microorganisms
US15/180,032 US9834794B2 (en) 2011-07-29 2016-06-12 Method for producing retinoid from microorganism

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20110075715 2011-07-29
KR10-2011-0075715 2011-07-29
KR1020120083185A KR101392159B1 (en) 2011-07-29 2012-07-30 Method of producing retinoids from a microorganism
KR10-2012-0083185 2012-07-30

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US14/235,841 A-371-Of-International US9644217B2 (en) 2011-07-29 2012-07-30 Method for producing retinoid from microorganism
US15/180,032 Continuation US9834794B2 (en) 2011-07-29 2016-06-12 Method for producing retinoid from microorganism

Publications (3)

Publication Number Publication Date
WO2013019051A2 WO2013019051A2 (en) 2013-02-07
WO2013019051A9 WO2013019051A9 (en) 2013-05-02
WO2013019051A3 true WO2013019051A3 (en) 2013-06-20

Family

ID=47629791

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/006071 Ceased WO2013019051A2 (en) 2011-07-29 2012-07-30 Method for producing retinoid from microorganism

Country Status (1)

Country Link
WO (1) WO2013019051A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140147982A (en) * 2013-06-20 2014-12-31 경상대학교산학협력단 Microorganism including genes coding enzymes involved in the production of retinoid and preparing method for retinoid using the same
CN117143951A (en) 2017-02-24 2023-12-01 新加坡科技研究局 Production of carotenoids and apocarotenoids
US11549117B2 (en) 2017-05-11 2023-01-10 Industry-Academic Cooperation Foundation Gyeongsang National University Marker composition for selecting living modified organism, living modified organism, and transformation method
KR102202606B1 (en) * 2018-11-30 2021-01-15 (주)바이오스플래시 A microorganism for producing a bio-retinol and a method for preparing a bio-retinol using the same
KR102518841B1 (en) 2021-11-09 2023-04-10 경상국립대학교산학협력단 Composition and method for preparing retinoids

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090078113A (en) * 2008-01-14 2009-07-17 경상대학교산학협력단 Isoprenoid Microorganisms with Improved Productivity and Methods for Producing Isoprenoids Using the Microorganisms

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090078113A (en) * 2008-01-14 2009-07-17 경상대학교산학협력단 Isoprenoid Microorganisms with Improved Productivity and Methods for Producing Isoprenoids Using the Microorganisms

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HA, B.-K. ET AL.: "Improved Retinoids Production from Metabolically Engineered Escherichia coli with a Two-phase Culture System.", JOURNAL OF KSBB CONFERENCE, April 2012 (2012-04-01), pages 185 *
JANG, H.-J. ET AL.: "Retinoid production using metabolically engineered Escherichia coli with a two-phase culture system.", MICROBIAL CELL FACTORIES, vol. 10, 29 July 2011 (2011-07-29), pages 59 *
KIM, Y. S. ET AL.: "Effective production of retinal from beta-carotene using recombinant mouse beta-carotene 15,15'-monooxygenase.", APPL. MICROBIOL. BIOTECHNOL., vol. 76, no. 6, October 2007 (2007-10-01), pages 1339 - 1345 *
YOON, K. W. ET AL.: "In situ recovery of lycopene during biosynthesis with recombinant Escherichia coli.", J. BIOTECHNOL., vol. 135, no. 3, 2008, pages 291 - 294 *

Also Published As

Publication number Publication date
WO2013019051A9 (en) 2013-05-02
WO2013019051A2 (en) 2013-02-07

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