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WO2013019051A3 - Procédé de production d'un rétinoïde par un micro-organisme - Google Patents

Procédé de production d'un rétinoïde par un micro-organisme Download PDF

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Publication number
WO2013019051A3
WO2013019051A3 PCT/KR2012/006071 KR2012006071W WO2013019051A3 WO 2013019051 A3 WO2013019051 A3 WO 2013019051A3 KR 2012006071 W KR2012006071 W KR 2012006071W WO 2013019051 A3 WO2013019051 A3 WO 2013019051A3
Authority
WO
WIPO (PCT)
Prior art keywords
microorganism
retinoid
producing
producing retinoid
lipophilic substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2012/006071
Other languages
English (en)
Korean (ko)
Other versions
WO2013019051A9 (fr
WO2013019051A2 (fr
Inventor
김선원
장희정
윤상활
하보경
류희경
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gyeongsang National University GNU
Original Assignee
Gyeongsang National University GNU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gyeongsang National University GNU filed Critical Gyeongsang National University GNU
Priority to US14/235,841 priority Critical patent/US9644217B2/en
Priority to CN201280042839.0A priority patent/CN103857786B/zh
Priority claimed from KR1020120083185A external-priority patent/KR101392159B1/ko
Publication of WO2013019051A2 publication Critical patent/WO2013019051A2/fr
Publication of WO2013019051A9 publication Critical patent/WO2013019051A9/fr
Publication of WO2013019051A3 publication Critical patent/WO2013019051A3/fr
Anticipated expiration legal-status Critical
Priority to US15/180,032 priority patent/US9834794B2/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes

Landscapes

  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention concerne un procédé de production d'un rétinoïde par un micro-organisme et, plus précisément, un procédé permettant d'obtenir de manière efficace un rétinoïde qui est instable. Le procédé comprend la culture du micro-organisme capable de produire un rétinoïde dans un milieu contenant une substance lipophile et la séparation du rétinoïde de la substance lipophile.
PCT/KR2012/006071 2011-07-29 2012-07-30 Procédé de production d'un rétinoïde par un micro-organisme Ceased WO2013019051A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US14/235,841 US9644217B2 (en) 2011-07-29 2012-07-30 Method for producing retinoid from microorganism
CN201280042839.0A CN103857786B (zh) 2011-07-29 2012-07-30 从微生物中制造类视黄醇的方法
US15/180,032 US9834794B2 (en) 2011-07-29 2016-06-12 Method for producing retinoid from microorganism

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20110075715 2011-07-29
KR10-2011-0075715 2011-07-29
KR1020120083185A KR101392159B1 (ko) 2011-07-29 2012-07-30 미생물로부터 레티노이드를 생산하는 방법
KR10-2012-0083185 2012-07-30

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US14/235,841 A-371-Of-International US9644217B2 (en) 2011-07-29 2012-07-30 Method for producing retinoid from microorganism
US15/180,032 Continuation US9834794B2 (en) 2011-07-29 2016-06-12 Method for producing retinoid from microorganism

Publications (3)

Publication Number Publication Date
WO2013019051A2 WO2013019051A2 (fr) 2013-02-07
WO2013019051A9 WO2013019051A9 (fr) 2013-05-02
WO2013019051A3 true WO2013019051A3 (fr) 2013-06-20

Family

ID=47629791

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/006071 Ceased WO2013019051A2 (fr) 2011-07-29 2012-07-30 Procédé de production d'un rétinoïde par un micro-organisme

Country Status (1)

Country Link
WO (1) WO2013019051A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140147982A (ko) * 2013-06-20 2014-12-31 경상대학교산학협력단 레티노이드 생산에 관여하는 효소를 코딩하는 유전자를 포함하는 미생물 및 이를 이용한 레티노이드의 생산 방법
CN117143951A (zh) 2017-02-24 2023-12-01 新加坡科技研究局 类胡萝卜素和脱辅基类胡萝卜素的生产
US11549117B2 (en) 2017-05-11 2023-01-10 Industry-Academic Cooperation Foundation Gyeongsang National University Marker composition for selecting living modified organism, living modified organism, and transformation method
KR102202606B1 (ko) * 2018-11-30 2021-01-15 (주)바이오스플래시 바이오레티놀을 생산하는 미생물 및 이를 이용한 바이오레티놀의 생산방법
KR102518841B1 (ko) 2021-11-09 2023-04-10 경상국립대학교산학협력단 레티노이드 제조용 조성물 및 이를 이용한 레티노이드의 제조 방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090078113A (ko) * 2008-01-14 2009-07-17 경상대학교산학협력단 이소프레노이드 생산성이 향상된 에세리키아 속 미생물 및그를 이용하여 이소프레노이드를 생산하는 방법

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090078113A (ko) * 2008-01-14 2009-07-17 경상대학교산학협력단 이소프레노이드 생산성이 향상된 에세리키아 속 미생물 및그를 이용하여 이소프레노이드를 생산하는 방법

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HA, B.-K. ET AL.: "Improved Retinoids Production from Metabolically Engineered Escherichia coli with a Two-phase Culture System.", JOURNAL OF KSBB CONFERENCE, April 2012 (2012-04-01), pages 185 *
JANG, H.-J. ET AL.: "Retinoid production using metabolically engineered Escherichia coli with a two-phase culture system.", MICROBIAL CELL FACTORIES, vol. 10, 29 July 2011 (2011-07-29), pages 59 *
KIM, Y. S. ET AL.: "Effective production of retinal from beta-carotene using recombinant mouse beta-carotene 15,15'-monooxygenase.", APPL. MICROBIOL. BIOTECHNOL., vol. 76, no. 6, October 2007 (2007-10-01), pages 1339 - 1345 *
YOON, K. W. ET AL.: "In situ recovery of lycopene during biosynthesis with recombinant Escherichia coli.", J. BIOTECHNOL., vol. 135, no. 3, 2008, pages 291 - 294 *

Also Published As

Publication number Publication date
WO2013019051A9 (fr) 2013-05-02
WO2013019051A2 (fr) 2013-02-07

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